CardioClasp Changes Left Ventricular Shape Acutely in Enlarged Canine Heart
Abstract Background: In dilated cardiomyopathy (DCM), eliminating or reducing extra-geometric burden to the myocardial cells would directly reduce myocardial wall stress leading to improved LV systolic performance. In acute experiments, we tested whether a passive non-blood contacting CardioClasp™ d...
Ausführliche Beschreibung
Gespeichert in:
| Autor*in: |
Kashem, Abul - M.D., Ph.D. Santamore, William P. - Ph.D. Hassan, Sarmina - M.D., Ph.D. Melvin, David B. - M.D., Ph.D. Crabbe, Deborah L. - M.D. Margulies, Kenneth B. - M.D. Goldman, Bruce I - M.D. Llort, Frank - Ph.D. Krieger, Carol - B.S. Lesniak, Jeanne - B.S. |
|---|
| Format: |
E-Artikel |
|---|
| Erschienen: |
350 Main Street , Malden , MA 02148 , USA. , and 9600 Garsington Road , Oxford OX4 2DQ , UK .: Blackwell Science Inc ; 2003 |
|---|
| Umfang: |
Online-Ressource |
|---|
| Reproduktion: |
2003 ; Blackwell Publishing Journal Backfiles 1879-2005 |
|---|---|
| Übergeordnetes Werk: |
In: Journal of cardiac surgery - Oxford : Wiley-Blackwell, 1986, 18(2003), Seite 0 |
| Übergeordnetes Werk: |
volume:18 ; year:2003 ; pages:0 |
| Links: |
|---|
| DOI / URN: |
10.1046/j.1540-8191.18.s2.5.x |
|---|
| Katalog-ID: |
NLEJ243085427 |
|---|
| LEADER | 01000caa a22002652 4500 | ||
|---|---|---|---|
| 001 | NLEJ243085427 | ||
| 003 | DE-627 | ||
| 005 | 20210707172310.0 | ||
| 007 | cr uuu---uuuuu | ||
| 008 | 120427s2003 xx |||||o 00| ||und c | ||
| 024 | 7 | |a 10.1046/j.1540-8191.18.s2.5.x |2 doi | |
| 035 | |a (DE-627)NLEJ243085427 | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rakwb | ||
| 245 | 1 | 0 | |a CardioClasp Changes Left Ventricular Shape Acutely in Enlarged Canine Heart |
| 264 | 1 | |a 350 Main Street , Malden , MA 02148 , USA. , and 9600 Garsington Road , Oxford OX4 2DQ , UK . |b Blackwell Science Inc |c 2003 | |
| 300 | |a Online-Ressource | ||
| 336 | |a nicht spezifiziert |b zzz |2 rdacontent | ||
| 337 | |a nicht spezifiziert |b z |2 rdamedia | ||
| 338 | |a nicht spezifiziert |b zu |2 rdacarrier | ||
| 520 | |a Abstract Background: In dilated cardiomyopathy (DCM), eliminating or reducing extra-geometric burden to the myocardial cells would directly reduce myocardial wall stress leading to improved LV systolic performance. In acute experiments, we tested whether a passive non-blood contacting CardioClasp™ device, which employs two indenting bars to reshape the left ventricle (LV), could reduce extra-geometric burden, LV wall stress (LVWS) and improve LV systolic function and contractility without decreasing arterial blood pressure. Methods: In mongrel dogs (n = 5), 4 weeks of right ventricular pacing (210–220–230–240 ppm) induced DCM with severe heart failure. After placing the CardioClasp™ device, LV performance was evaluated immediately by measuring hemodynamics, echocardiography, and Sonometrics® crystal data. Eleven sonometric crystals were placed into endocardial positions (8 in anterior, posterior, mid-anterior, mid-posterior, apex, base, free and septal wall) and in myocardial (2 as regional) and epicardial (1) positions to assess the LV end-systolic pressure-segment length relationships (ESPSR) and cross-sectional area (ESPAR) relationship. Results: CardioClasp™ decreased the LV end-diastolic anterior-posterior (A-P) dimensions at two levels (15% and 25%). With CardioClasp™, LVWS decreased from 93.1 ± 7.2 to 59.1 ± 3.2 g/cm2 (P < 0.05) and fractional area of contraction (FAC) increased from 27.6 ± 3.8 to 33.1 ± 3.7% (P < 0.01). Peak LV and arterial pressures, LV +dP/dt, LV −dP/dt, and cardiac output were unaltered with CardioClasp™. CardioClasp™ placement significantly increased the slopes of LV pressure versus anterior-posterior segment relationship from 7.3 ± 0.6 to 15.8 ± 1.8 mmHg/mm and septal-free wall segment relationship from 6.3 ± 0.9 to 9.8 ± 0.5 mmHg/mm. At both 15% and 25% LV A-P dimension reductions, the slopes of ESPAR showed significant steepening and increased from 10.1 ± 0.7 (baseline) to 15.5 ± 1.7 (15% reduction) and 19.0 ± 1.4 mmHg/cm2 (25% reduction). The larger the reduction, the greater was the steepening of the slopes of ESPSR and ESPAR. Conclusions: CardioClasp™ reduced LV diameter and thereby decreased LVWS and increased FAC. CardioClasp™ was able to reshape the left ventricle, while preserving the contractile mass, which increased the slopes of ESPSR and ESPAR. This reshaping was associated with maintained systolic pressures, cardiac output, and increased contractility. (J Card Surg 2003;18(Suppl 2):S49-S60) | ||
| 533 | |d 2003 |f Blackwell Publishing Journal Backfiles 1879-2005 |7 |2003|||||||||| | ||
| 700 | 1 | |a Kashem, Abul |c M.D., Ph.D. |4 oth | |
| 700 | 1 | |a Santamore, William P. |c Ph.D. |4 oth | |
| 700 | 1 | |a Hassan, Sarmina |c M.D., Ph.D. |4 oth | |
| 700 | 1 | |a Melvin, David B. |c M.D., Ph.D. |4 oth | |
| 700 | 1 | |a Crabbe, Deborah L. |c M.D. |4 oth | |
| 700 | 1 | |a Margulies, Kenneth B. |c M.D. |4 oth | |
| 700 | 1 | |a Goldman, Bruce I |c M.D. |4 oth | |
| 700 | 1 | |a Llort, Frank |c Ph.D. |4 oth | |
| 700 | 1 | |a Krieger, Carol |c B.S. |4 oth | |
| 700 | 1 | |a Lesniak, Jeanne |c B.S. |4 oth | |
| 773 | 0 | 8 | |i In |t Journal of cardiac surgery |d Oxford : Wiley-Blackwell, 1986 |g 18(2003), Seite 0 |h Online-Ressource |w (DE-627)NLEJ243926588 |w (DE-600)2108425-7 |x 1540-8191 |7 nnns |
| 773 | 1 | 8 | |g volume:18 |g year:2003 |g pages:0 |
| 856 | 4 | 0 | |u http://dx.doi.org/10.1046/j.1540-8191.18.s2.5.x |q text/html |x Verlag |z Deutschlandweit zugänglich |3 Volltext |
| 912 | |a GBV_USEFLAG_U | ||
| 912 | |a ZDB-1-DJB | ||
| 912 | |a GBV_NL_ARTICLE | ||
| 951 | |a AR | ||
| 952 | |d 18 |j 2003 |h 0 | ||
| matchkey_str |
article:15408191:2003----::adolscagsetetiuasaectlie |
|---|---|
| hierarchy_sort_str |
2003 |
| publishDate |
2003 |
| allfields |
10.1046/j.1540-8191.18.s2.5.x doi (DE-627)NLEJ243085427 DE-627 ger DE-627 rakwb CardioClasp Changes Left Ventricular Shape Acutely in Enlarged Canine Heart 350 Main Street , Malden , MA 02148 , USA. , and 9600 Garsington Road , Oxford OX4 2DQ , UK . Blackwell Science Inc 2003 Online-Ressource nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Abstract Background: In dilated cardiomyopathy (DCM), eliminating or reducing extra-geometric burden to the myocardial cells would directly reduce myocardial wall stress leading to improved LV systolic performance. In acute experiments, we tested whether a passive non-blood contacting CardioClasp™ device, which employs two indenting bars to reshape the left ventricle (LV), could reduce extra-geometric burden, LV wall stress (LVWS) and improve LV systolic function and contractility without decreasing arterial blood pressure. Methods: In mongrel dogs (n = 5), 4 weeks of right ventricular pacing (210–220–230–240 ppm) induced DCM with severe heart failure. After placing the CardioClasp™ device, LV performance was evaluated immediately by measuring hemodynamics, echocardiography, and Sonometrics® crystal data. Eleven sonometric crystals were placed into endocardial positions (8 in anterior, posterior, mid-anterior, mid-posterior, apex, base, free and septal wall) and in myocardial (2 as regional) and epicardial (1) positions to assess the LV end-systolic pressure-segment length relationships (ESPSR) and cross-sectional area (ESPAR) relationship. Results: CardioClasp™ decreased the LV end-diastolic anterior-posterior (A-P) dimensions at two levels (15% and 25%). With CardioClasp™, LVWS decreased from 93.1 ± 7.2 to 59.1 ± 3.2 g/cm2 (P < 0.05) and fractional area of contraction (FAC) increased from 27.6 ± 3.8 to 33.1 ± 3.7% (P < 0.01). Peak LV and arterial pressures, LV +dP/dt, LV −dP/dt, and cardiac output were unaltered with CardioClasp™. CardioClasp™ placement significantly increased the slopes of LV pressure versus anterior-posterior segment relationship from 7.3 ± 0.6 to 15.8 ± 1.8 mmHg/mm and septal-free wall segment relationship from 6.3 ± 0.9 to 9.8 ± 0.5 mmHg/mm. At both 15% and 25% LV A-P dimension reductions, the slopes of ESPAR showed significant steepening and increased from 10.1 ± 0.7 (baseline) to 15.5 ± 1.7 (15% reduction) and 19.0 ± 1.4 mmHg/cm2 (25% reduction). The larger the reduction, the greater was the steepening of the slopes of ESPSR and ESPAR. Conclusions: CardioClasp™ reduced LV diameter and thereby decreased LVWS and increased FAC. CardioClasp™ was able to reshape the left ventricle, while preserving the contractile mass, which increased the slopes of ESPSR and ESPAR. This reshaping was associated with maintained systolic pressures, cardiac output, and increased contractility. (J Card Surg 2003;18(Suppl 2):S49-S60) 2003 Blackwell Publishing Journal Backfiles 1879-2005 |2003|||||||||| Kashem, Abul M.D., Ph.D. oth Santamore, William P. Ph.D. oth Hassan, Sarmina M.D., Ph.D. oth Melvin, David B. M.D., Ph.D. oth Crabbe, Deborah L. M.D. oth Margulies, Kenneth B. M.D. oth Goldman, Bruce I M.D. oth Llort, Frank Ph.D. oth Krieger, Carol B.S. oth Lesniak, Jeanne B.S. oth In Journal of cardiac surgery Oxford : Wiley-Blackwell, 1986 18(2003), Seite 0 Online-Ressource (DE-627)NLEJ243926588 (DE-600)2108425-7 1540-8191 nnns volume:18 year:2003 pages:0 http://dx.doi.org/10.1046/j.1540-8191.18.s2.5.x text/html Verlag Deutschlandweit zugänglich Volltext GBV_USEFLAG_U ZDB-1-DJB GBV_NL_ARTICLE AR 18 2003 0 |
| spelling |
10.1046/j.1540-8191.18.s2.5.x doi (DE-627)NLEJ243085427 DE-627 ger DE-627 rakwb CardioClasp Changes Left Ventricular Shape Acutely in Enlarged Canine Heart 350 Main Street , Malden , MA 02148 , USA. , and 9600 Garsington Road , Oxford OX4 2DQ , UK . Blackwell Science Inc 2003 Online-Ressource nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Abstract Background: In dilated cardiomyopathy (DCM), eliminating or reducing extra-geometric burden to the myocardial cells would directly reduce myocardial wall stress leading to improved LV systolic performance. In acute experiments, we tested whether a passive non-blood contacting CardioClasp™ device, which employs two indenting bars to reshape the left ventricle (LV), could reduce extra-geometric burden, LV wall stress (LVWS) and improve LV systolic function and contractility without decreasing arterial blood pressure. Methods: In mongrel dogs (n = 5), 4 weeks of right ventricular pacing (210–220–230–240 ppm) induced DCM with severe heart failure. After placing the CardioClasp™ device, LV performance was evaluated immediately by measuring hemodynamics, echocardiography, and Sonometrics® crystal data. Eleven sonometric crystals were placed into endocardial positions (8 in anterior, posterior, mid-anterior, mid-posterior, apex, base, free and septal wall) and in myocardial (2 as regional) and epicardial (1) positions to assess the LV end-systolic pressure-segment length relationships (ESPSR) and cross-sectional area (ESPAR) relationship. Results: CardioClasp™ decreased the LV end-diastolic anterior-posterior (A-P) dimensions at two levels (15% and 25%). With CardioClasp™, LVWS decreased from 93.1 ± 7.2 to 59.1 ± 3.2 g/cm2 (P < 0.05) and fractional area of contraction (FAC) increased from 27.6 ± 3.8 to 33.1 ± 3.7% (P < 0.01). Peak LV and arterial pressures, LV +dP/dt, LV −dP/dt, and cardiac output were unaltered with CardioClasp™. CardioClasp™ placement significantly increased the slopes of LV pressure versus anterior-posterior segment relationship from 7.3 ± 0.6 to 15.8 ± 1.8 mmHg/mm and septal-free wall segment relationship from 6.3 ± 0.9 to 9.8 ± 0.5 mmHg/mm. At both 15% and 25% LV A-P dimension reductions, the slopes of ESPAR showed significant steepening and increased from 10.1 ± 0.7 (baseline) to 15.5 ± 1.7 (15% reduction) and 19.0 ± 1.4 mmHg/cm2 (25% reduction). The larger the reduction, the greater was the steepening of the slopes of ESPSR and ESPAR. Conclusions: CardioClasp™ reduced LV diameter and thereby decreased LVWS and increased FAC. CardioClasp™ was able to reshape the left ventricle, while preserving the contractile mass, which increased the slopes of ESPSR and ESPAR. This reshaping was associated with maintained systolic pressures, cardiac output, and increased contractility. (J Card Surg 2003;18(Suppl 2):S49-S60) 2003 Blackwell Publishing Journal Backfiles 1879-2005 |2003|||||||||| Kashem, Abul M.D., Ph.D. oth Santamore, William P. Ph.D. oth Hassan, Sarmina M.D., Ph.D. oth Melvin, David B. M.D., Ph.D. oth Crabbe, Deborah L. M.D. oth Margulies, Kenneth B. M.D. oth Goldman, Bruce I M.D. oth Llort, Frank Ph.D. oth Krieger, Carol B.S. oth Lesniak, Jeanne B.S. oth In Journal of cardiac surgery Oxford : Wiley-Blackwell, 1986 18(2003), Seite 0 Online-Ressource (DE-627)NLEJ243926588 (DE-600)2108425-7 1540-8191 nnns volume:18 year:2003 pages:0 http://dx.doi.org/10.1046/j.1540-8191.18.s2.5.x text/html Verlag Deutschlandweit zugänglich Volltext GBV_USEFLAG_U ZDB-1-DJB GBV_NL_ARTICLE AR 18 2003 0 |
| allfields_unstemmed |
10.1046/j.1540-8191.18.s2.5.x doi (DE-627)NLEJ243085427 DE-627 ger DE-627 rakwb CardioClasp Changes Left Ventricular Shape Acutely in Enlarged Canine Heart 350 Main Street , Malden , MA 02148 , USA. , and 9600 Garsington Road , Oxford OX4 2DQ , UK . Blackwell Science Inc 2003 Online-Ressource nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Abstract Background: In dilated cardiomyopathy (DCM), eliminating or reducing extra-geometric burden to the myocardial cells would directly reduce myocardial wall stress leading to improved LV systolic performance. In acute experiments, we tested whether a passive non-blood contacting CardioClasp™ device, which employs two indenting bars to reshape the left ventricle (LV), could reduce extra-geometric burden, LV wall stress (LVWS) and improve LV systolic function and contractility without decreasing arterial blood pressure. Methods: In mongrel dogs (n = 5), 4 weeks of right ventricular pacing (210–220–230–240 ppm) induced DCM with severe heart failure. After placing the CardioClasp™ device, LV performance was evaluated immediately by measuring hemodynamics, echocardiography, and Sonometrics® crystal data. Eleven sonometric crystals were placed into endocardial positions (8 in anterior, posterior, mid-anterior, mid-posterior, apex, base, free and septal wall) and in myocardial (2 as regional) and epicardial (1) positions to assess the LV end-systolic pressure-segment length relationships (ESPSR) and cross-sectional area (ESPAR) relationship. Results: CardioClasp™ decreased the LV end-diastolic anterior-posterior (A-P) dimensions at two levels (15% and 25%). With CardioClasp™, LVWS decreased from 93.1 ± 7.2 to 59.1 ± 3.2 g/cm2 (P < 0.05) and fractional area of contraction (FAC) increased from 27.6 ± 3.8 to 33.1 ± 3.7% (P < 0.01). Peak LV and arterial pressures, LV +dP/dt, LV −dP/dt, and cardiac output were unaltered with CardioClasp™. CardioClasp™ placement significantly increased the slopes of LV pressure versus anterior-posterior segment relationship from 7.3 ± 0.6 to 15.8 ± 1.8 mmHg/mm and septal-free wall segment relationship from 6.3 ± 0.9 to 9.8 ± 0.5 mmHg/mm. At both 15% and 25% LV A-P dimension reductions, the slopes of ESPAR showed significant steepening and increased from 10.1 ± 0.7 (baseline) to 15.5 ± 1.7 (15% reduction) and 19.0 ± 1.4 mmHg/cm2 (25% reduction). The larger the reduction, the greater was the steepening of the slopes of ESPSR and ESPAR. Conclusions: CardioClasp™ reduced LV diameter and thereby decreased LVWS and increased FAC. CardioClasp™ was able to reshape the left ventricle, while preserving the contractile mass, which increased the slopes of ESPSR and ESPAR. This reshaping was associated with maintained systolic pressures, cardiac output, and increased contractility. (J Card Surg 2003;18(Suppl 2):S49-S60) 2003 Blackwell Publishing Journal Backfiles 1879-2005 |2003|||||||||| Kashem, Abul M.D., Ph.D. oth Santamore, William P. Ph.D. oth Hassan, Sarmina M.D., Ph.D. oth Melvin, David B. M.D., Ph.D. oth Crabbe, Deborah L. M.D. oth Margulies, Kenneth B. M.D. oth Goldman, Bruce I M.D. oth Llort, Frank Ph.D. oth Krieger, Carol B.S. oth Lesniak, Jeanne B.S. oth In Journal of cardiac surgery Oxford : Wiley-Blackwell, 1986 18(2003), Seite 0 Online-Ressource (DE-627)NLEJ243926588 (DE-600)2108425-7 1540-8191 nnns volume:18 year:2003 pages:0 http://dx.doi.org/10.1046/j.1540-8191.18.s2.5.x text/html Verlag Deutschlandweit zugänglich Volltext GBV_USEFLAG_U ZDB-1-DJB GBV_NL_ARTICLE AR 18 2003 0 |
| allfieldsGer |
10.1046/j.1540-8191.18.s2.5.x doi (DE-627)NLEJ243085427 DE-627 ger DE-627 rakwb CardioClasp Changes Left Ventricular Shape Acutely in Enlarged Canine Heart 350 Main Street , Malden , MA 02148 , USA. , and 9600 Garsington Road , Oxford OX4 2DQ , UK . Blackwell Science Inc 2003 Online-Ressource nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Abstract Background: In dilated cardiomyopathy (DCM), eliminating or reducing extra-geometric burden to the myocardial cells would directly reduce myocardial wall stress leading to improved LV systolic performance. In acute experiments, we tested whether a passive non-blood contacting CardioClasp™ device, which employs two indenting bars to reshape the left ventricle (LV), could reduce extra-geometric burden, LV wall stress (LVWS) and improve LV systolic function and contractility without decreasing arterial blood pressure. Methods: In mongrel dogs (n = 5), 4 weeks of right ventricular pacing (210–220–230–240 ppm) induced DCM with severe heart failure. After placing the CardioClasp™ device, LV performance was evaluated immediately by measuring hemodynamics, echocardiography, and Sonometrics® crystal data. Eleven sonometric crystals were placed into endocardial positions (8 in anterior, posterior, mid-anterior, mid-posterior, apex, base, free and septal wall) and in myocardial (2 as regional) and epicardial (1) positions to assess the LV end-systolic pressure-segment length relationships (ESPSR) and cross-sectional area (ESPAR) relationship. Results: CardioClasp™ decreased the LV end-diastolic anterior-posterior (A-P) dimensions at two levels (15% and 25%). With CardioClasp™, LVWS decreased from 93.1 ± 7.2 to 59.1 ± 3.2 g/cm2 (P < 0.05) and fractional area of contraction (FAC) increased from 27.6 ± 3.8 to 33.1 ± 3.7% (P < 0.01). Peak LV and arterial pressures, LV +dP/dt, LV −dP/dt, and cardiac output were unaltered with CardioClasp™. CardioClasp™ placement significantly increased the slopes of LV pressure versus anterior-posterior segment relationship from 7.3 ± 0.6 to 15.8 ± 1.8 mmHg/mm and septal-free wall segment relationship from 6.3 ± 0.9 to 9.8 ± 0.5 mmHg/mm. At both 15% and 25% LV A-P dimension reductions, the slopes of ESPAR showed significant steepening and increased from 10.1 ± 0.7 (baseline) to 15.5 ± 1.7 (15% reduction) and 19.0 ± 1.4 mmHg/cm2 (25% reduction). The larger the reduction, the greater was the steepening of the slopes of ESPSR and ESPAR. Conclusions: CardioClasp™ reduced LV diameter and thereby decreased LVWS and increased FAC. CardioClasp™ was able to reshape the left ventricle, while preserving the contractile mass, which increased the slopes of ESPSR and ESPAR. This reshaping was associated with maintained systolic pressures, cardiac output, and increased contractility. (J Card Surg 2003;18(Suppl 2):S49-S60) 2003 Blackwell Publishing Journal Backfiles 1879-2005 |2003|||||||||| Kashem, Abul M.D., Ph.D. oth Santamore, William P. Ph.D. oth Hassan, Sarmina M.D., Ph.D. oth Melvin, David B. M.D., Ph.D. oth Crabbe, Deborah L. M.D. oth Margulies, Kenneth B. M.D. oth Goldman, Bruce I M.D. oth Llort, Frank Ph.D. oth Krieger, Carol B.S. oth Lesniak, Jeanne B.S. oth In Journal of cardiac surgery Oxford : Wiley-Blackwell, 1986 18(2003), Seite 0 Online-Ressource (DE-627)NLEJ243926588 (DE-600)2108425-7 1540-8191 nnns volume:18 year:2003 pages:0 http://dx.doi.org/10.1046/j.1540-8191.18.s2.5.x text/html Verlag Deutschlandweit zugänglich Volltext GBV_USEFLAG_U ZDB-1-DJB GBV_NL_ARTICLE AR 18 2003 0 |
| allfieldsSound |
10.1046/j.1540-8191.18.s2.5.x doi (DE-627)NLEJ243085427 DE-627 ger DE-627 rakwb CardioClasp Changes Left Ventricular Shape Acutely in Enlarged Canine Heart 350 Main Street , Malden , MA 02148 , USA. , and 9600 Garsington Road , Oxford OX4 2DQ , UK . Blackwell Science Inc 2003 Online-Ressource nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Abstract Background: In dilated cardiomyopathy (DCM), eliminating or reducing extra-geometric burden to the myocardial cells would directly reduce myocardial wall stress leading to improved LV systolic performance. In acute experiments, we tested whether a passive non-blood contacting CardioClasp™ device, which employs two indenting bars to reshape the left ventricle (LV), could reduce extra-geometric burden, LV wall stress (LVWS) and improve LV systolic function and contractility without decreasing arterial blood pressure. Methods: In mongrel dogs (n = 5), 4 weeks of right ventricular pacing (210–220–230–240 ppm) induced DCM with severe heart failure. After placing the CardioClasp™ device, LV performance was evaluated immediately by measuring hemodynamics, echocardiography, and Sonometrics® crystal data. Eleven sonometric crystals were placed into endocardial positions (8 in anterior, posterior, mid-anterior, mid-posterior, apex, base, free and septal wall) and in myocardial (2 as regional) and epicardial (1) positions to assess the LV end-systolic pressure-segment length relationships (ESPSR) and cross-sectional area (ESPAR) relationship. Results: CardioClasp™ decreased the LV end-diastolic anterior-posterior (A-P) dimensions at two levels (15% and 25%). With CardioClasp™, LVWS decreased from 93.1 ± 7.2 to 59.1 ± 3.2 g/cm2 (P < 0.05) and fractional area of contraction (FAC) increased from 27.6 ± 3.8 to 33.1 ± 3.7% (P < 0.01). Peak LV and arterial pressures, LV +dP/dt, LV −dP/dt, and cardiac output were unaltered with CardioClasp™. CardioClasp™ placement significantly increased the slopes of LV pressure versus anterior-posterior segment relationship from 7.3 ± 0.6 to 15.8 ± 1.8 mmHg/mm and septal-free wall segment relationship from 6.3 ± 0.9 to 9.8 ± 0.5 mmHg/mm. At both 15% and 25% LV A-P dimension reductions, the slopes of ESPAR showed significant steepening and increased from 10.1 ± 0.7 (baseline) to 15.5 ± 1.7 (15% reduction) and 19.0 ± 1.4 mmHg/cm2 (25% reduction). The larger the reduction, the greater was the steepening of the slopes of ESPSR and ESPAR. Conclusions: CardioClasp™ reduced LV diameter and thereby decreased LVWS and increased FAC. CardioClasp™ was able to reshape the left ventricle, while preserving the contractile mass, which increased the slopes of ESPSR and ESPAR. This reshaping was associated with maintained systolic pressures, cardiac output, and increased contractility. (J Card Surg 2003;18(Suppl 2):S49-S60) 2003 Blackwell Publishing Journal Backfiles 1879-2005 |2003|||||||||| Kashem, Abul M.D., Ph.D. oth Santamore, William P. Ph.D. oth Hassan, Sarmina M.D., Ph.D. oth Melvin, David B. M.D., Ph.D. oth Crabbe, Deborah L. M.D. oth Margulies, Kenneth B. M.D. oth Goldman, Bruce I M.D. oth Llort, Frank Ph.D. oth Krieger, Carol B.S. oth Lesniak, Jeanne B.S. oth In Journal of cardiac surgery Oxford : Wiley-Blackwell, 1986 18(2003), Seite 0 Online-Ressource (DE-627)NLEJ243926588 (DE-600)2108425-7 1540-8191 nnns volume:18 year:2003 pages:0 http://dx.doi.org/10.1046/j.1540-8191.18.s2.5.x text/html Verlag Deutschlandweit zugänglich Volltext GBV_USEFLAG_U ZDB-1-DJB GBV_NL_ARTICLE AR 18 2003 0 |
| source |
In Journal of cardiac surgery 18(2003), Seite 0 volume:18 year:2003 pages:0 |
| sourceStr |
In Journal of cardiac surgery 18(2003), Seite 0 volume:18 year:2003 pages:0 |
| format_phy_str_mv |
Article |
| institution |
findex.gbv.de |
| isfreeaccess_bool |
false |
| container_title |
Journal of cardiac surgery |
| authorswithroles_txt_mv |
Kashem, Abul @@oth@@ Santamore, William P. @@oth@@ Hassan, Sarmina @@oth@@ Melvin, David B. @@oth@@ Crabbe, Deborah L. @@oth@@ Margulies, Kenneth B. @@oth@@ Goldman, Bruce I @@oth@@ Llort, Frank @@oth@@ Krieger, Carol @@oth@@ Lesniak, Jeanne @@oth@@ |
| publishDateDaySort_date |
2003-01-01T00:00:00Z |
| hierarchy_top_id |
NLEJ243926588 |
| id |
NLEJ243085427 |
| fullrecord |
<?xml version="1.0" encoding="UTF-8"?><collection xmlns="http://www.loc.gov/MARC21/slim"><record><leader>01000caa a22002652 4500</leader><controlfield tag="001">NLEJ243085427</controlfield><controlfield tag="003">DE-627</controlfield><controlfield tag="005">20210707172310.0</controlfield><controlfield tag="007">cr uuu---uuuuu</controlfield><controlfield tag="008">120427s2003 xx |||||o 00| ||und c</controlfield><datafield tag="024" ind1="7" ind2=" "><subfield code="a">10.1046/j.1540-8191.18.s2.5.x</subfield><subfield code="2">doi</subfield></datafield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(DE-627)NLEJ243085427</subfield></datafield><datafield tag="040" ind1=" " ind2=" "><subfield code="a">DE-627</subfield><subfield code="b">ger</subfield><subfield code="c">DE-627</subfield><subfield code="e">rakwb</subfield></datafield><datafield tag="245" ind1="1" ind2="0"><subfield code="a">CardioClasp Changes Left Ventricular Shape Acutely in Enlarged Canine Heart</subfield></datafield><datafield tag="264" ind1=" " ind2="1"><subfield code="a">350 Main Street , Malden , MA 02148 , USA. , and 9600 Garsington Road , Oxford OX4 2DQ , UK .</subfield><subfield code="b">Blackwell Science Inc</subfield><subfield code="c">2003</subfield></datafield><datafield tag="300" ind1=" " ind2=" "><subfield code="a">Online-Ressource</subfield></datafield><datafield tag="336" ind1=" " ind2=" "><subfield code="a">nicht spezifiziert</subfield><subfield code="b">zzz</subfield><subfield code="2">rdacontent</subfield></datafield><datafield tag="337" ind1=" " ind2=" "><subfield code="a">nicht spezifiziert</subfield><subfield code="b">z</subfield><subfield code="2">rdamedia</subfield></datafield><datafield tag="338" ind1=" " ind2=" "><subfield code="a">nicht spezifiziert</subfield><subfield code="b">zu</subfield><subfield code="2">rdacarrier</subfield></datafield><datafield tag="520" ind1=" " ind2=" "><subfield code="a">Abstract Background: In dilated cardiomyopathy (DCM), eliminating or reducing extra-geometric burden to the myocardial cells would directly reduce myocardial wall stress leading to improved LV systolic performance. In acute experiments, we tested whether a passive non-blood contacting CardioClasp™ device, which employs two indenting bars to reshape the left ventricle (LV), could reduce extra-geometric burden, LV wall stress (LVWS) and improve LV systolic function and contractility without decreasing arterial blood pressure. Methods: In mongrel dogs (n = 5), 4 weeks of right ventricular pacing (210–220–230–240 ppm) induced DCM with severe heart failure. After placing the CardioClasp™ device, LV performance was evaluated immediately by measuring hemodynamics, echocardiography, and Sonometrics® crystal data. Eleven sonometric crystals were placed into endocardial positions (8 in anterior, posterior, mid-anterior, mid-posterior, apex, base, free and septal wall) and in myocardial (2 as regional) and epicardial (1) positions to assess the LV end-systolic pressure-segment length relationships (ESPSR) and cross-sectional area (ESPAR) relationship. Results: CardioClasp™ decreased the LV end-diastolic anterior-posterior (A-P) dimensions at two levels (15% and 25%). With CardioClasp™, LVWS decreased from 93.1 ± 7.2 to 59.1 ± 3.2 g/cm2 (P < 0.05) and fractional area of contraction (FAC) increased from 27.6 ± 3.8 to 33.1 ± 3.7% (P < 0.01). Peak LV and arterial pressures, LV +dP/dt, LV −dP/dt, and cardiac output were unaltered with CardioClasp™. CardioClasp™ placement significantly increased the slopes of LV pressure versus anterior-posterior segment relationship from 7.3 ± 0.6 to 15.8 ± 1.8 mmHg/mm and septal-free wall segment relationship from 6.3 ± 0.9 to 9.8 ± 0.5 mmHg/mm. At both 15% and 25% LV A-P dimension reductions, the slopes of ESPAR showed significant steepening and increased from 10.1 ± 0.7 (baseline) to 15.5 ± 1.7 (15% reduction) and 19.0 ± 1.4 mmHg/cm2 (25% reduction). The larger the reduction, the greater was the steepening of the slopes of ESPSR and ESPAR. Conclusions: CardioClasp™ reduced LV diameter and thereby decreased LVWS and increased FAC. CardioClasp™ was able to reshape the left ventricle, while preserving the contractile mass, which increased the slopes of ESPSR and ESPAR. This reshaping was associated with maintained systolic pressures, cardiac output, and increased contractility. (J Card Surg 2003;18(Suppl 2):S49-S60)</subfield></datafield><datafield tag="533" ind1=" " ind2=" "><subfield code="d">2003</subfield><subfield code="f">Blackwell Publishing Journal Backfiles 1879-2005</subfield><subfield code="7">|2003||||||||||</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Kashem, Abul</subfield><subfield code="c">M.D., Ph.D.</subfield><subfield code="4">oth</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Santamore, William P.</subfield><subfield code="c">Ph.D.</subfield><subfield code="4">oth</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Hassan, Sarmina</subfield><subfield code="c">M.D., Ph.D.</subfield><subfield code="4">oth</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Melvin, David B.</subfield><subfield code="c">M.D., Ph.D.</subfield><subfield code="4">oth</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Crabbe, Deborah L.</subfield><subfield code="c">M.D.</subfield><subfield code="4">oth</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Margulies, Kenneth B.</subfield><subfield code="c">M.D.</subfield><subfield code="4">oth</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Goldman, Bruce I</subfield><subfield code="c">M.D.</subfield><subfield code="4">oth</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Llort, Frank</subfield><subfield code="c">Ph.D.</subfield><subfield code="4">oth</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Krieger, Carol</subfield><subfield code="c">B.S.</subfield><subfield code="4">oth</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Lesniak, Jeanne</subfield><subfield code="c">B.S.</subfield><subfield code="4">oth</subfield></datafield><datafield tag="773" ind1="0" ind2="8"><subfield code="i">In</subfield><subfield code="t">Journal of cardiac surgery</subfield><subfield code="d">Oxford : Wiley-Blackwell, 1986</subfield><subfield code="g">18(2003), Seite 0</subfield><subfield code="h">Online-Ressource</subfield><subfield code="w">(DE-627)NLEJ243926588</subfield><subfield code="w">(DE-600)2108425-7</subfield><subfield code="x">1540-8191</subfield><subfield code="7">nnns</subfield></datafield><datafield tag="773" ind1="1" ind2="8"><subfield code="g">volume:18</subfield><subfield code="g">year:2003</subfield><subfield code="g">pages:0</subfield></datafield><datafield tag="856" ind1="4" ind2="0"><subfield code="u">http://dx.doi.org/10.1046/j.1540-8191.18.s2.5.x</subfield><subfield code="q">text/html</subfield><subfield code="x">Verlag</subfield><subfield code="z">Deutschlandweit zugänglich</subfield><subfield code="3">Volltext</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_USEFLAG_U</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">ZDB-1-DJB</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_NL_ARTICLE</subfield></datafield><datafield tag="951" ind1=" " ind2=" "><subfield code="a">AR</subfield></datafield><datafield tag="952" ind1=" " ind2=" "><subfield code="d">18</subfield><subfield code="j">2003</subfield><subfield code="h">0</subfield></datafield></record></collection>
|
| series2 |
Blackwell Publishing Journal Backfiles 1879-2005 |
| ppnlink_with_tag_str_mv |
@@773@@(DE-627)NLEJ243926588 |
| format |
electronic Article |
| delete_txt_mv |
keep |
| collection |
NL |
| publishPlace |
350 Main Street , Malden , MA 02148 , USA. , and 9600 Garsington Road , Oxford OX4 2DQ , UK . |
| remote_str |
true |
| illustrated |
Not Illustrated |
| issn |
1540-8191 |
| topic_title |
CardioClasp Changes Left Ventricular Shape Acutely in Enlarged Canine Heart |
| publisher |
Blackwell Science Inc |
| publisherStr |
Blackwell Science Inc |
| format_facet |
Elektronische Aufsätze Aufsätze Elektronische Ressource |
| format_main_str_mv |
Text Zeitschrift/Artikel |
| carriertype_str_mv |
zu |
| author2_variant |
a k ak w p s wp wps s h sh d b m db dbm d l c dl dlc k b m kb kbm b i g bi big f l fl c k ck j l jl |
| hierarchy_parent_title |
Journal of cardiac surgery |
| hierarchy_parent_id |
NLEJ243926588 |
| hierarchy_top_title |
Journal of cardiac surgery |
| isfreeaccess_txt |
false |
| familylinks_str_mv |
(DE-627)NLEJ243926588 (DE-600)2108425-7 |
| title |
CardioClasp Changes Left Ventricular Shape Acutely in Enlarged Canine Heart |
| spellingShingle |
CardioClasp Changes Left Ventricular Shape Acutely in Enlarged Canine Heart |
| ctrlnum |
(DE-627)NLEJ243085427 |
| title_full |
CardioClasp Changes Left Ventricular Shape Acutely in Enlarged Canine Heart |
| journal |
Journal of cardiac surgery |
| journalStr |
Journal of cardiac surgery |
| isOA_bool |
false |
| recordtype |
marc |
| publishDateSort |
2003 |
| contenttype_str_mv |
zzz |
| container_start_page |
0 |
| container_volume |
18 |
| physical |
Online-Ressource |
| format_se |
Elektronische Aufsätze |
| doi_str_mv |
10.1046/j.1540-8191.18.s2.5.x |
| title_sort |
cardioclasp changes left ventricular shape acutely in enlarged canine heart |
| title_auth |
CardioClasp Changes Left Ventricular Shape Acutely in Enlarged Canine Heart |
| abstract |
Abstract Background: In dilated cardiomyopathy (DCM), eliminating or reducing extra-geometric burden to the myocardial cells would directly reduce myocardial wall stress leading to improved LV systolic performance. In acute experiments, we tested whether a passive non-blood contacting CardioClasp™ device, which employs two indenting bars to reshape the left ventricle (LV), could reduce extra-geometric burden, LV wall stress (LVWS) and improve LV systolic function and contractility without decreasing arterial blood pressure. Methods: In mongrel dogs (n = 5), 4 weeks of right ventricular pacing (210–220–230–240 ppm) induced DCM with severe heart failure. After placing the CardioClasp™ device, LV performance was evaluated immediately by measuring hemodynamics, echocardiography, and Sonometrics® crystal data. Eleven sonometric crystals were placed into endocardial positions (8 in anterior, posterior, mid-anterior, mid-posterior, apex, base, free and septal wall) and in myocardial (2 as regional) and epicardial (1) positions to assess the LV end-systolic pressure-segment length relationships (ESPSR) and cross-sectional area (ESPAR) relationship. Results: CardioClasp™ decreased the LV end-diastolic anterior-posterior (A-P) dimensions at two levels (15% and 25%). With CardioClasp™, LVWS decreased from 93.1 ± 7.2 to 59.1 ± 3.2 g/cm2 (P < 0.05) and fractional area of contraction (FAC) increased from 27.6 ± 3.8 to 33.1 ± 3.7% (P < 0.01). Peak LV and arterial pressures, LV +dP/dt, LV −dP/dt, and cardiac output were unaltered with CardioClasp™. CardioClasp™ placement significantly increased the slopes of LV pressure versus anterior-posterior segment relationship from 7.3 ± 0.6 to 15.8 ± 1.8 mmHg/mm and septal-free wall segment relationship from 6.3 ± 0.9 to 9.8 ± 0.5 mmHg/mm. At both 15% and 25% LV A-P dimension reductions, the slopes of ESPAR showed significant steepening and increased from 10.1 ± 0.7 (baseline) to 15.5 ± 1.7 (15% reduction) and 19.0 ± 1.4 mmHg/cm2 (25% reduction). The larger the reduction, the greater was the steepening of the slopes of ESPSR and ESPAR. Conclusions: CardioClasp™ reduced LV diameter and thereby decreased LVWS and increased FAC. CardioClasp™ was able to reshape the left ventricle, while preserving the contractile mass, which increased the slopes of ESPSR and ESPAR. This reshaping was associated with maintained systolic pressures, cardiac output, and increased contractility. (J Card Surg 2003;18(Suppl 2):S49-S60) |
| abstractGer |
Abstract Background: In dilated cardiomyopathy (DCM), eliminating or reducing extra-geometric burden to the myocardial cells would directly reduce myocardial wall stress leading to improved LV systolic performance. In acute experiments, we tested whether a passive non-blood contacting CardioClasp™ device, which employs two indenting bars to reshape the left ventricle (LV), could reduce extra-geometric burden, LV wall stress (LVWS) and improve LV systolic function and contractility without decreasing arterial blood pressure. Methods: In mongrel dogs (n = 5), 4 weeks of right ventricular pacing (210–220–230–240 ppm) induced DCM with severe heart failure. After placing the CardioClasp™ device, LV performance was evaluated immediately by measuring hemodynamics, echocardiography, and Sonometrics® crystal data. Eleven sonometric crystals were placed into endocardial positions (8 in anterior, posterior, mid-anterior, mid-posterior, apex, base, free and septal wall) and in myocardial (2 as regional) and epicardial (1) positions to assess the LV end-systolic pressure-segment length relationships (ESPSR) and cross-sectional area (ESPAR) relationship. Results: CardioClasp™ decreased the LV end-diastolic anterior-posterior (A-P) dimensions at two levels (15% and 25%). With CardioClasp™, LVWS decreased from 93.1 ± 7.2 to 59.1 ± 3.2 g/cm2 (P < 0.05) and fractional area of contraction (FAC) increased from 27.6 ± 3.8 to 33.1 ± 3.7% (P < 0.01). Peak LV and arterial pressures, LV +dP/dt, LV −dP/dt, and cardiac output were unaltered with CardioClasp™. CardioClasp™ placement significantly increased the slopes of LV pressure versus anterior-posterior segment relationship from 7.3 ± 0.6 to 15.8 ± 1.8 mmHg/mm and septal-free wall segment relationship from 6.3 ± 0.9 to 9.8 ± 0.5 mmHg/mm. At both 15% and 25% LV A-P dimension reductions, the slopes of ESPAR showed significant steepening and increased from 10.1 ± 0.7 (baseline) to 15.5 ± 1.7 (15% reduction) and 19.0 ± 1.4 mmHg/cm2 (25% reduction). The larger the reduction, the greater was the steepening of the slopes of ESPSR and ESPAR. Conclusions: CardioClasp™ reduced LV diameter and thereby decreased LVWS and increased FAC. CardioClasp™ was able to reshape the left ventricle, while preserving the contractile mass, which increased the slopes of ESPSR and ESPAR. This reshaping was associated with maintained systolic pressures, cardiac output, and increased contractility. (J Card Surg 2003;18(Suppl 2):S49-S60) |
| abstract_unstemmed |
Abstract Background: In dilated cardiomyopathy (DCM), eliminating or reducing extra-geometric burden to the myocardial cells would directly reduce myocardial wall stress leading to improved LV systolic performance. In acute experiments, we tested whether a passive non-blood contacting CardioClasp™ device, which employs two indenting bars to reshape the left ventricle (LV), could reduce extra-geometric burden, LV wall stress (LVWS) and improve LV systolic function and contractility without decreasing arterial blood pressure. Methods: In mongrel dogs (n = 5), 4 weeks of right ventricular pacing (210–220–230–240 ppm) induced DCM with severe heart failure. After placing the CardioClasp™ device, LV performance was evaluated immediately by measuring hemodynamics, echocardiography, and Sonometrics® crystal data. Eleven sonometric crystals were placed into endocardial positions (8 in anterior, posterior, mid-anterior, mid-posterior, apex, base, free and septal wall) and in myocardial (2 as regional) and epicardial (1) positions to assess the LV end-systolic pressure-segment length relationships (ESPSR) and cross-sectional area (ESPAR) relationship. Results: CardioClasp™ decreased the LV end-diastolic anterior-posterior (A-P) dimensions at two levels (15% and 25%). With CardioClasp™, LVWS decreased from 93.1 ± 7.2 to 59.1 ± 3.2 g/cm2 (P < 0.05) and fractional area of contraction (FAC) increased from 27.6 ± 3.8 to 33.1 ± 3.7% (P < 0.01). Peak LV and arterial pressures, LV +dP/dt, LV −dP/dt, and cardiac output were unaltered with CardioClasp™. CardioClasp™ placement significantly increased the slopes of LV pressure versus anterior-posterior segment relationship from 7.3 ± 0.6 to 15.8 ± 1.8 mmHg/mm and septal-free wall segment relationship from 6.3 ± 0.9 to 9.8 ± 0.5 mmHg/mm. At both 15% and 25% LV A-P dimension reductions, the slopes of ESPAR showed significant steepening and increased from 10.1 ± 0.7 (baseline) to 15.5 ± 1.7 (15% reduction) and 19.0 ± 1.4 mmHg/cm2 (25% reduction). The larger the reduction, the greater was the steepening of the slopes of ESPSR and ESPAR. Conclusions: CardioClasp™ reduced LV diameter and thereby decreased LVWS and increased FAC. CardioClasp™ was able to reshape the left ventricle, while preserving the contractile mass, which increased the slopes of ESPSR and ESPAR. This reshaping was associated with maintained systolic pressures, cardiac output, and increased contractility. (J Card Surg 2003;18(Suppl 2):S49-S60) |
| collection_details |
GBV_USEFLAG_U ZDB-1-DJB GBV_NL_ARTICLE |
| title_short |
CardioClasp Changes Left Ventricular Shape Acutely in Enlarged Canine Heart |
| url |
http://dx.doi.org/10.1046/j.1540-8191.18.s2.5.x |
| remote_bool |
true |
| author2 |
Kashem, Abul M.D., Ph.D. Santamore, William P. Ph.D. Hassan, Sarmina M.D., Ph.D. Melvin, David B. M.D., Ph.D. Crabbe, Deborah L. M.D. Margulies, Kenneth B. M.D. Goldman, Bruce I M.D. Llort, Frank Ph.D. Krieger, Carol B.S. Lesniak, Jeanne B.S. |
| author2Str |
Kashem, Abul M.D., Ph.D. Santamore, William P. Ph.D. Hassan, Sarmina M.D., Ph.D. Melvin, David B. M.D., Ph.D. Crabbe, Deborah L. M.D. Margulies, Kenneth B. M.D. Goldman, Bruce I M.D. Llort, Frank Ph.D. Krieger, Carol B.S. Lesniak, Jeanne B.S. |
| ppnlink |
NLEJ243926588 |
| mediatype_str_mv |
z |
| isOA_txt |
false |
| hochschulschrift_bool |
false |
| author2_role |
oth oth oth oth oth oth oth oth oth oth |
| doi_str |
10.1046/j.1540-8191.18.s2.5.x |
| up_date |
2024-07-06T04:13:37.320Z |
| _version_ |
1803801557541584896 |
| fullrecord_marcxml |
<?xml version="1.0" encoding="UTF-8"?><collection xmlns="http://www.loc.gov/MARC21/slim"><record><leader>01000caa a22002652 4500</leader><controlfield tag="001">NLEJ243085427</controlfield><controlfield tag="003">DE-627</controlfield><controlfield tag="005">20210707172310.0</controlfield><controlfield tag="007">cr uuu---uuuuu</controlfield><controlfield tag="008">120427s2003 xx |||||o 00| ||und c</controlfield><datafield tag="024" ind1="7" ind2=" "><subfield code="a">10.1046/j.1540-8191.18.s2.5.x</subfield><subfield code="2">doi</subfield></datafield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(DE-627)NLEJ243085427</subfield></datafield><datafield tag="040" ind1=" " ind2=" "><subfield code="a">DE-627</subfield><subfield code="b">ger</subfield><subfield code="c">DE-627</subfield><subfield code="e">rakwb</subfield></datafield><datafield tag="245" ind1="1" ind2="0"><subfield code="a">CardioClasp Changes Left Ventricular Shape Acutely in Enlarged Canine Heart</subfield></datafield><datafield tag="264" ind1=" " ind2="1"><subfield code="a">350 Main Street , Malden , MA 02148 , USA. , and 9600 Garsington Road , Oxford OX4 2DQ , UK .</subfield><subfield code="b">Blackwell Science Inc</subfield><subfield code="c">2003</subfield></datafield><datafield tag="300" ind1=" " ind2=" "><subfield code="a">Online-Ressource</subfield></datafield><datafield tag="336" ind1=" " ind2=" "><subfield code="a">nicht spezifiziert</subfield><subfield code="b">zzz</subfield><subfield code="2">rdacontent</subfield></datafield><datafield tag="337" ind1=" " ind2=" "><subfield code="a">nicht spezifiziert</subfield><subfield code="b">z</subfield><subfield code="2">rdamedia</subfield></datafield><datafield tag="338" ind1=" " ind2=" "><subfield code="a">nicht spezifiziert</subfield><subfield code="b">zu</subfield><subfield code="2">rdacarrier</subfield></datafield><datafield tag="520" ind1=" " ind2=" "><subfield code="a">Abstract Background: In dilated cardiomyopathy (DCM), eliminating or reducing extra-geometric burden to the myocardial cells would directly reduce myocardial wall stress leading to improved LV systolic performance. In acute experiments, we tested whether a passive non-blood contacting CardioClasp™ device, which employs two indenting bars to reshape the left ventricle (LV), could reduce extra-geometric burden, LV wall stress (LVWS) and improve LV systolic function and contractility without decreasing arterial blood pressure. Methods: In mongrel dogs (n = 5), 4 weeks of right ventricular pacing (210–220–230–240 ppm) induced DCM with severe heart failure. After placing the CardioClasp™ device, LV performance was evaluated immediately by measuring hemodynamics, echocardiography, and Sonometrics® crystal data. Eleven sonometric crystals were placed into endocardial positions (8 in anterior, posterior, mid-anterior, mid-posterior, apex, base, free and septal wall) and in myocardial (2 as regional) and epicardial (1) positions to assess the LV end-systolic pressure-segment length relationships (ESPSR) and cross-sectional area (ESPAR) relationship. Results: CardioClasp™ decreased the LV end-diastolic anterior-posterior (A-P) dimensions at two levels (15% and 25%). With CardioClasp™, LVWS decreased from 93.1 ± 7.2 to 59.1 ± 3.2 g/cm2 (P < 0.05) and fractional area of contraction (FAC) increased from 27.6 ± 3.8 to 33.1 ± 3.7% (P < 0.01). Peak LV and arterial pressures, LV +dP/dt, LV −dP/dt, and cardiac output were unaltered with CardioClasp™. CardioClasp™ placement significantly increased the slopes of LV pressure versus anterior-posterior segment relationship from 7.3 ± 0.6 to 15.8 ± 1.8 mmHg/mm and septal-free wall segment relationship from 6.3 ± 0.9 to 9.8 ± 0.5 mmHg/mm. At both 15% and 25% LV A-P dimension reductions, the slopes of ESPAR showed significant steepening and increased from 10.1 ± 0.7 (baseline) to 15.5 ± 1.7 (15% reduction) and 19.0 ± 1.4 mmHg/cm2 (25% reduction). The larger the reduction, the greater was the steepening of the slopes of ESPSR and ESPAR. Conclusions: CardioClasp™ reduced LV diameter and thereby decreased LVWS and increased FAC. CardioClasp™ was able to reshape the left ventricle, while preserving the contractile mass, which increased the slopes of ESPSR and ESPAR. This reshaping was associated with maintained systolic pressures, cardiac output, and increased contractility. (J Card Surg 2003;18(Suppl 2):S49-S60)</subfield></datafield><datafield tag="533" ind1=" " ind2=" "><subfield code="d">2003</subfield><subfield code="f">Blackwell Publishing Journal Backfiles 1879-2005</subfield><subfield code="7">|2003||||||||||</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Kashem, Abul</subfield><subfield code="c">M.D., Ph.D.</subfield><subfield code="4">oth</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Santamore, William P.</subfield><subfield code="c">Ph.D.</subfield><subfield code="4">oth</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Hassan, Sarmina</subfield><subfield code="c">M.D., Ph.D.</subfield><subfield code="4">oth</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Melvin, David B.</subfield><subfield code="c">M.D., Ph.D.</subfield><subfield code="4">oth</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Crabbe, Deborah L.</subfield><subfield code="c">M.D.</subfield><subfield code="4">oth</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Margulies, Kenneth B.</subfield><subfield code="c">M.D.</subfield><subfield code="4">oth</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Goldman, Bruce I</subfield><subfield code="c">M.D.</subfield><subfield code="4">oth</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Llort, Frank</subfield><subfield code="c">Ph.D.</subfield><subfield code="4">oth</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Krieger, Carol</subfield><subfield code="c">B.S.</subfield><subfield code="4">oth</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Lesniak, Jeanne</subfield><subfield code="c">B.S.</subfield><subfield code="4">oth</subfield></datafield><datafield tag="773" ind1="0" ind2="8"><subfield code="i">In</subfield><subfield code="t">Journal of cardiac surgery</subfield><subfield code="d">Oxford : Wiley-Blackwell, 1986</subfield><subfield code="g">18(2003), Seite 0</subfield><subfield code="h">Online-Ressource</subfield><subfield code="w">(DE-627)NLEJ243926588</subfield><subfield code="w">(DE-600)2108425-7</subfield><subfield code="x">1540-8191</subfield><subfield code="7">nnns</subfield></datafield><datafield tag="773" ind1="1" ind2="8"><subfield code="g">volume:18</subfield><subfield code="g">year:2003</subfield><subfield code="g">pages:0</subfield></datafield><datafield tag="856" ind1="4" ind2="0"><subfield code="u">http://dx.doi.org/10.1046/j.1540-8191.18.s2.5.x</subfield><subfield code="q">text/html</subfield><subfield code="x">Verlag</subfield><subfield code="z">Deutschlandweit zugänglich</subfield><subfield code="3">Volltext</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_USEFLAG_U</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">ZDB-1-DJB</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_NL_ARTICLE</subfield></datafield><datafield tag="951" ind1=" " ind2=" "><subfield code="a">AR</subfield></datafield><datafield tag="952" ind1=" " ind2=" "><subfield code="d">18</subfield><subfield code="j">2003</subfield><subfield code="h">0</subfield></datafield></record></collection>
|
| score |
7.4009676 |