Lipopolysaccharide and Interleukin-1β Augmented Histidine Decarboxylase Activity in Cultured Cells of the Rat Embryonic Brain
Abstract: We investigated the effect of lipopolysaccharide (LPS) and various inflammatory cytokines on the histidine decarboxylase (HDC) activity in cultured cells of the rat embryonic brain. Histaminergic neuronal cell bodies were supposed to exist in cultured cells of the diencephalon but not in t...
Ausführliche Beschreibung
Gespeichert in:
| Autor*in: |
Niimi, Mitsuhiro [verfasserIn] Yamamoto, Yumiko [verfasserIn] Takemori, Hiroshi [verfasserIn] |
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| Format: |
E-Artikel |
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| Erschienen: |
Oxford, UK: Blackwell Science Ltd ; 1997 |
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| Schlagwörter: |
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| Umfang: |
Online-Ressource |
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| Reproduktion: |
2002 ; Blackwell Publishing Journal Backfiles 1879-2005 |
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| Übergeordnetes Werk: |
In: Journal of neurochemistry - Oxford : Wiley-Blackwell, 1956, 69(1997), 2, Seite 0 |
| Übergeordnetes Werk: |
volume:69 ; year:1997 ; number:2 ; pages:0 |
| Links: |
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| DOI / URN: |
10.1046/j.1471-4159.1997.69020851.x |
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| 520 | |a Abstract: We investigated the effect of lipopolysaccharide (LPS) and various inflammatory cytokines on the histidine decarboxylase (HDC) activity in cultured cells of the rat embryonic brain. Histaminergic neuronal cell bodies were supposed to exist in cultured cells of the diencephalon but not in those of the cortex. The HDC activity was elevated by adding LPS and interleukin-1 β (IL-1β) but not by tumor necrosis factor-α (TNF-α) and IL-6 to the mixed primary cultures of diencephalon. In the adherent cell fraction of the cultured diencephalon cells, HDC activity was also enhanced by LPS and IL-1β. In a similar manner, LPS augmented HDC activity in the mixed primary culture of cerebral cortical cells and in its adherent cell fraction. The effects of IL-1β but not LPS in the mixed primary culture of diencephalon were canceled by a prior exposure to cytosine-β-d-arabinofuranoside. The changes in HDC activity after exposure to LPS for 12 h were not accompanied by increased mRNA levels. In these cell cultures, mast cells were not detected by Alcian Blue staining. These results indicated the presence of the third type of HDC-bearing cell besides neurons and mast cells in the brain. The increase of HDC activity by IL-1β might be due to cell proliferation. | ||
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| 700 | 1 | |a Kondo, Yuki |4 oth | |
| 700 | 1 | |a Yamatodani, Atsushi |4 oth | |
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10.1046/j.1471-4159.1997.69020851.x doi (DE-627)NLEJ243167148 DE-627 ger DE-627 rakwb Niimi, Mitsuhiro verfasserin aut Lipopolysaccharide and Interleukin-1β Augmented Histidine Decarboxylase Activity in Cultured Cells of the Rat Embryonic Brain Oxford, UK Blackwell Science Ltd 1997 Online-Ressource nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Abstract: We investigated the effect of lipopolysaccharide (LPS) and various inflammatory cytokines on the histidine decarboxylase (HDC) activity in cultured cells of the rat embryonic brain. Histaminergic neuronal cell bodies were supposed to exist in cultured cells of the diencephalon but not in those of the cortex. The HDC activity was elevated by adding LPS and interleukin-1 β (IL-1β) but not by tumor necrosis factor-α (TNF-α) and IL-6 to the mixed primary cultures of diencephalon. In the adherent cell fraction of the cultured diencephalon cells, HDC activity was also enhanced by LPS and IL-1β. In a similar manner, LPS augmented HDC activity in the mixed primary culture of cerebral cortical cells and in its adherent cell fraction. The effects of IL-1β but not LPS in the mixed primary culture of diencephalon were canceled by a prior exposure to cytosine-β-d-arabinofuranoside. The changes in HDC activity after exposure to LPS for 12 h were not accompanied by increased mRNA levels. In these cell cultures, mast cells were not detected by Alcian Blue staining. These results indicated the presence of the third type of HDC-bearing cell besides neurons and mast cells in the brain. The increase of HDC activity by IL-1β might be due to cell proliferation. 2002 Blackwell Publishing Journal Backfiles 1879-2005 |2002|||||||||| Histidine decarboxylase Yamamoto, Yumiko verfasserin aut Takemori, Hiroshi verfasserin aut Uno, Atsuhiko oth Kondo, Yuki oth Yamatodani, Atsushi oth In Journal of neurochemistry Oxford : Wiley-Blackwell, 1956 69(1997), 2, Seite 0 Online-Ressource (DE-627)NLEJ243927584 (DE-600)2020528-4 1471-4159 nnns volume:69 year:1997 number:2 pages:0 http://dx.doi.org/10.1046/j.1471-4159.1997.69020851.x text/html Verlag Deutschlandweit zugänglich Volltext GBV_USEFLAG_U ZDB-1-DJB GBV_NL_ARTICLE AR 69 1997 2 0 |
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10.1046/j.1471-4159.1997.69020851.x doi (DE-627)NLEJ243167148 DE-627 ger DE-627 rakwb Niimi, Mitsuhiro verfasserin aut Lipopolysaccharide and Interleukin-1β Augmented Histidine Decarboxylase Activity in Cultured Cells of the Rat Embryonic Brain Oxford, UK Blackwell Science Ltd 1997 Online-Ressource nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Abstract: We investigated the effect of lipopolysaccharide (LPS) and various inflammatory cytokines on the histidine decarboxylase (HDC) activity in cultured cells of the rat embryonic brain. Histaminergic neuronal cell bodies were supposed to exist in cultured cells of the diencephalon but not in those of the cortex. The HDC activity was elevated by adding LPS and interleukin-1 β (IL-1β) but not by tumor necrosis factor-α (TNF-α) and IL-6 to the mixed primary cultures of diencephalon. In the adherent cell fraction of the cultured diencephalon cells, HDC activity was also enhanced by LPS and IL-1β. In a similar manner, LPS augmented HDC activity in the mixed primary culture of cerebral cortical cells and in its adherent cell fraction. The effects of IL-1β but not LPS in the mixed primary culture of diencephalon were canceled by a prior exposure to cytosine-β-d-arabinofuranoside. The changes in HDC activity after exposure to LPS for 12 h were not accompanied by increased mRNA levels. In these cell cultures, mast cells were not detected by Alcian Blue staining. These results indicated the presence of the third type of HDC-bearing cell besides neurons and mast cells in the brain. The increase of HDC activity by IL-1β might be due to cell proliferation. 2002 Blackwell Publishing Journal Backfiles 1879-2005 |2002|||||||||| Histidine decarboxylase Yamamoto, Yumiko verfasserin aut Takemori, Hiroshi verfasserin aut Uno, Atsuhiko oth Kondo, Yuki oth Yamatodani, Atsushi oth In Journal of neurochemistry Oxford : Wiley-Blackwell, 1956 69(1997), 2, Seite 0 Online-Ressource (DE-627)NLEJ243927584 (DE-600)2020528-4 1471-4159 nnns volume:69 year:1997 number:2 pages:0 http://dx.doi.org/10.1046/j.1471-4159.1997.69020851.x text/html Verlag Deutschlandweit zugänglich Volltext GBV_USEFLAG_U ZDB-1-DJB GBV_NL_ARTICLE AR 69 1997 2 0 |
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10.1046/j.1471-4159.1997.69020851.x doi (DE-627)NLEJ243167148 DE-627 ger DE-627 rakwb Niimi, Mitsuhiro verfasserin aut Lipopolysaccharide and Interleukin-1β Augmented Histidine Decarboxylase Activity in Cultured Cells of the Rat Embryonic Brain Oxford, UK Blackwell Science Ltd 1997 Online-Ressource nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Abstract: We investigated the effect of lipopolysaccharide (LPS) and various inflammatory cytokines on the histidine decarboxylase (HDC) activity in cultured cells of the rat embryonic brain. Histaminergic neuronal cell bodies were supposed to exist in cultured cells of the diencephalon but not in those of the cortex. The HDC activity was elevated by adding LPS and interleukin-1 β (IL-1β) but not by tumor necrosis factor-α (TNF-α) and IL-6 to the mixed primary cultures of diencephalon. In the adherent cell fraction of the cultured diencephalon cells, HDC activity was also enhanced by LPS and IL-1β. In a similar manner, LPS augmented HDC activity in the mixed primary culture of cerebral cortical cells and in its adherent cell fraction. The effects of IL-1β but not LPS in the mixed primary culture of diencephalon were canceled by a prior exposure to cytosine-β-d-arabinofuranoside. The changes in HDC activity after exposure to LPS for 12 h were not accompanied by increased mRNA levels. In these cell cultures, mast cells were not detected by Alcian Blue staining. These results indicated the presence of the third type of HDC-bearing cell besides neurons and mast cells in the brain. The increase of HDC activity by IL-1β might be due to cell proliferation. 2002 Blackwell Publishing Journal Backfiles 1879-2005 |2002|||||||||| Histidine decarboxylase Yamamoto, Yumiko verfasserin aut Takemori, Hiroshi verfasserin aut Uno, Atsuhiko oth Kondo, Yuki oth Yamatodani, Atsushi oth In Journal of neurochemistry Oxford : Wiley-Blackwell, 1956 69(1997), 2, Seite 0 Online-Ressource (DE-627)NLEJ243927584 (DE-600)2020528-4 1471-4159 nnns volume:69 year:1997 number:2 pages:0 http://dx.doi.org/10.1046/j.1471-4159.1997.69020851.x text/html Verlag Deutschlandweit zugänglich Volltext GBV_USEFLAG_U ZDB-1-DJB GBV_NL_ARTICLE AR 69 1997 2 0 |
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10.1046/j.1471-4159.1997.69020851.x doi (DE-627)NLEJ243167148 DE-627 ger DE-627 rakwb Niimi, Mitsuhiro verfasserin aut Lipopolysaccharide and Interleukin-1β Augmented Histidine Decarboxylase Activity in Cultured Cells of the Rat Embryonic Brain Oxford, UK Blackwell Science Ltd 1997 Online-Ressource nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Abstract: We investigated the effect of lipopolysaccharide (LPS) and various inflammatory cytokines on the histidine decarboxylase (HDC) activity in cultured cells of the rat embryonic brain. Histaminergic neuronal cell bodies were supposed to exist in cultured cells of the diencephalon but not in those of the cortex. The HDC activity was elevated by adding LPS and interleukin-1 β (IL-1β) but not by tumor necrosis factor-α (TNF-α) and IL-6 to the mixed primary cultures of diencephalon. In the adherent cell fraction of the cultured diencephalon cells, HDC activity was also enhanced by LPS and IL-1β. In a similar manner, LPS augmented HDC activity in the mixed primary culture of cerebral cortical cells and in its adherent cell fraction. The effects of IL-1β but not LPS in the mixed primary culture of diencephalon were canceled by a prior exposure to cytosine-β-d-arabinofuranoside. The changes in HDC activity after exposure to LPS for 12 h were not accompanied by increased mRNA levels. In these cell cultures, mast cells were not detected by Alcian Blue staining. These results indicated the presence of the third type of HDC-bearing cell besides neurons and mast cells in the brain. The increase of HDC activity by IL-1β might be due to cell proliferation. 2002 Blackwell Publishing Journal Backfiles 1879-2005 |2002|||||||||| Histidine decarboxylase Yamamoto, Yumiko verfasserin aut Takemori, Hiroshi verfasserin aut Uno, Atsuhiko oth Kondo, Yuki oth Yamatodani, Atsushi oth In Journal of neurochemistry Oxford : Wiley-Blackwell, 1956 69(1997), 2, Seite 0 Online-Ressource (DE-627)NLEJ243927584 (DE-600)2020528-4 1471-4159 nnns volume:69 year:1997 number:2 pages:0 http://dx.doi.org/10.1046/j.1471-4159.1997.69020851.x text/html Verlag Deutschlandweit zugänglich Volltext GBV_USEFLAG_U ZDB-1-DJB GBV_NL_ARTICLE AR 69 1997 2 0 |
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10.1046/j.1471-4159.1997.69020851.x doi (DE-627)NLEJ243167148 DE-627 ger DE-627 rakwb Niimi, Mitsuhiro verfasserin aut Lipopolysaccharide and Interleukin-1β Augmented Histidine Decarboxylase Activity in Cultured Cells of the Rat Embryonic Brain Oxford, UK Blackwell Science Ltd 1997 Online-Ressource nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Abstract: We investigated the effect of lipopolysaccharide (LPS) and various inflammatory cytokines on the histidine decarboxylase (HDC) activity in cultured cells of the rat embryonic brain. Histaminergic neuronal cell bodies were supposed to exist in cultured cells of the diencephalon but not in those of the cortex. The HDC activity was elevated by adding LPS and interleukin-1 β (IL-1β) but not by tumor necrosis factor-α (TNF-α) and IL-6 to the mixed primary cultures of diencephalon. In the adherent cell fraction of the cultured diencephalon cells, HDC activity was also enhanced by LPS and IL-1β. In a similar manner, LPS augmented HDC activity in the mixed primary culture of cerebral cortical cells and in its adherent cell fraction. The effects of IL-1β but not LPS in the mixed primary culture of diencephalon were canceled by a prior exposure to cytosine-β-d-arabinofuranoside. The changes in HDC activity after exposure to LPS for 12 h were not accompanied by increased mRNA levels. In these cell cultures, mast cells were not detected by Alcian Blue staining. These results indicated the presence of the third type of HDC-bearing cell besides neurons and mast cells in the brain. The increase of HDC activity by IL-1β might be due to cell proliferation. 2002 Blackwell Publishing Journal Backfiles 1879-2005 |2002|||||||||| Histidine decarboxylase Yamamoto, Yumiko verfasserin aut Takemori, Hiroshi verfasserin aut Uno, Atsuhiko oth Kondo, Yuki oth Yamatodani, Atsushi oth In Journal of neurochemistry Oxford : Wiley-Blackwell, 1956 69(1997), 2, Seite 0 Online-Ressource (DE-627)NLEJ243927584 (DE-600)2020528-4 1471-4159 nnns volume:69 year:1997 number:2 pages:0 http://dx.doi.org/10.1046/j.1471-4159.1997.69020851.x text/html Verlag Deutschlandweit zugänglich Volltext GBV_USEFLAG_U ZDB-1-DJB GBV_NL_ARTICLE AR 69 1997 2 0 |
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Lipopolysaccharide and Interleukin-1β Augmented Histidine Decarboxylase Activity in Cultured Cells of the Rat Embryonic Brain |
| abstract |
Abstract: We investigated the effect of lipopolysaccharide (LPS) and various inflammatory cytokines on the histidine decarboxylase (HDC) activity in cultured cells of the rat embryonic brain. Histaminergic neuronal cell bodies were supposed to exist in cultured cells of the diencephalon but not in those of the cortex. The HDC activity was elevated by adding LPS and interleukin-1 β (IL-1β) but not by tumor necrosis factor-α (TNF-α) and IL-6 to the mixed primary cultures of diencephalon. In the adherent cell fraction of the cultured diencephalon cells, HDC activity was also enhanced by LPS and IL-1β. In a similar manner, LPS augmented HDC activity in the mixed primary culture of cerebral cortical cells and in its adherent cell fraction. The effects of IL-1β but not LPS in the mixed primary culture of diencephalon were canceled by a prior exposure to cytosine-β-d-arabinofuranoside. The changes in HDC activity after exposure to LPS for 12 h were not accompanied by increased mRNA levels. In these cell cultures, mast cells were not detected by Alcian Blue staining. These results indicated the presence of the third type of HDC-bearing cell besides neurons and mast cells in the brain. The increase of HDC activity by IL-1β might be due to cell proliferation. |
| abstractGer |
Abstract: We investigated the effect of lipopolysaccharide (LPS) and various inflammatory cytokines on the histidine decarboxylase (HDC) activity in cultured cells of the rat embryonic brain. Histaminergic neuronal cell bodies were supposed to exist in cultured cells of the diencephalon but not in those of the cortex. The HDC activity was elevated by adding LPS and interleukin-1 β (IL-1β) but not by tumor necrosis factor-α (TNF-α) and IL-6 to the mixed primary cultures of diencephalon. In the adherent cell fraction of the cultured diencephalon cells, HDC activity was also enhanced by LPS and IL-1β. In a similar manner, LPS augmented HDC activity in the mixed primary culture of cerebral cortical cells and in its adherent cell fraction. The effects of IL-1β but not LPS in the mixed primary culture of diencephalon were canceled by a prior exposure to cytosine-β-d-arabinofuranoside. The changes in HDC activity after exposure to LPS for 12 h were not accompanied by increased mRNA levels. In these cell cultures, mast cells were not detected by Alcian Blue staining. These results indicated the presence of the third type of HDC-bearing cell besides neurons and mast cells in the brain. The increase of HDC activity by IL-1β might be due to cell proliferation. |
| abstract_unstemmed |
Abstract: We investigated the effect of lipopolysaccharide (LPS) and various inflammatory cytokines on the histidine decarboxylase (HDC) activity in cultured cells of the rat embryonic brain. Histaminergic neuronal cell bodies were supposed to exist in cultured cells of the diencephalon but not in those of the cortex. The HDC activity was elevated by adding LPS and interleukin-1 β (IL-1β) but not by tumor necrosis factor-α (TNF-α) and IL-6 to the mixed primary cultures of diencephalon. In the adherent cell fraction of the cultured diencephalon cells, HDC activity was also enhanced by LPS and IL-1β. In a similar manner, LPS augmented HDC activity in the mixed primary culture of cerebral cortical cells and in its adherent cell fraction. The effects of IL-1β but not LPS in the mixed primary culture of diencephalon were canceled by a prior exposure to cytosine-β-d-arabinofuranoside. The changes in HDC activity after exposure to LPS for 12 h were not accompanied by increased mRNA levels. In these cell cultures, mast cells were not detected by Alcian Blue staining. These results indicated the presence of the third type of HDC-bearing cell besides neurons and mast cells in the brain. The increase of HDC activity by IL-1β might be due to cell proliferation. |
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| title_short |
Lipopolysaccharide and Interleukin-1β Augmented Histidine Decarboxylase Activity in Cultured Cells of the Rat Embryonic Brain |
| url |
http://dx.doi.org/10.1046/j.1471-4159.1997.69020851.x |
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Yamamoto, Yumiko Takemori, Hiroshi Uno, Atsuhiko Kondo, Yuki Yamatodani, Atsushi |
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Yamamoto, Yumiko Takemori, Hiroshi Uno, Atsuhiko Kondo, Yuki Yamatodani, Atsushi |
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| doi_str |
10.1046/j.1471-4159.1997.69020851.x |
| up_date |
2024-07-06T04:32:57.476Z |
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