High sibling correlation on methylphenidate response but no association with DAT1-10R homozygosity in Dutch sibpairs with ADHD
Background: A minority of patients with attention-deficit hyperactivity disorder (ADHD) do not respond favorably to methylphenidate. This has been partially associated with homozygosity for the Dopamine transporter (DAT1) 10-repeat allele and the presence of one or two Dopamine D4 receptor (DRD4) 7...
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| Autor*in: |
Meulen, Emma M. [verfasserIn] Bakker, Steven C. [verfasserIn] Pauls, David L. [verfasserIn] |
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| Format: |
E-Artikel |
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| Erschienen: |
Oxford, UK: Blackwell Publishing ; 2005 |
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| Schlagwörter: |
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| Umfang: |
Online-Ressource |
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| Reproduktion: |
2005 ; Blackwell Publishing Journal Backfiles 1879-2005 |
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| Übergeordnetes Werk: |
In: The journal of child psychology and psychiatry - Oxford : Wiley-Blackwell, 1960, 46(2005), 10, Seite 0 |
| Übergeordnetes Werk: |
volume:46 ; year:2005 ; number:10 ; pages:0 |
| Links: |
|---|
| DOI / URN: |
10.1111/j.1469-7610.2005.01521.x |
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| Katalog-ID: |
NLEJ243309287 |
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| 245 | 1 | 0 | |a High sibling correlation on methylphenidate response but no association with DAT1-10R homozygosity in Dutch sibpairs with ADHD |
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| 520 | |a Background: A minority of patients with attention-deficit hyperactivity disorder (ADHD) do not respond favorably to methylphenidate. This has been partially associated with homozygosity for the Dopamine transporter (DAT1) 10-repeat allele and the presence of one or two Dopamine D4 receptor (DRD4) 7-repeat alleles. This study examined the sibling correlation of methylphenidate response rate and the possible association between response rate and these risk alleles.Methods: A sample of 82 Dutch children with ADHD, from 54 families, (including 30 singletons and 28 sib pairs), who used methylphenidate, was phenotyped according to DSM-IV criteria. Patients were members of affected sib pairs and were genotyped for DAT1 and DRD4. The sibling Intraclass Correlation Coefficient for methylphenidate response rate was calculated. The association between individual response rates and the risk alleles was examined using linear regression techniques.Results: The Intraclass Correlation Coefficient was significant (r = .563, p = .001). No evidence was found establishing an association between methylphenidate response and DAT1-homozygosity. There was a positive trend towards association with the presence of one or two DRD4-7R alleles.Conclusions: The sibling correlation may indicate a familial clustering of methylphenidate response. This response is possibly associated with the presence of one or two alleles at the DRD4-7R locus, but not with DAT1-10R homozygosity in the Dutch population. | ||
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| 700 | 1 | |a Pauls, David L. |e verfasserin |4 aut | |
| 700 | 1 | |a Oteman, Nicole |4 oth | |
| 700 | 1 | |a Kruitwagen, Cas L.J.J. |4 oth | |
| 700 | 1 | |a Pearson, Peter L. |4 oth | |
| 700 | 1 | |a Sinke, Richard J. |4 oth | |
| 700 | 1 | |a Buitelaar, Jan K. |4 oth | |
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10.1111/j.1469-7610.2005.01521.x doi (DE-627)NLEJ243309287 DE-627 ger DE-627 rakwb Meulen, Emma M. verfasserin aut High sibling correlation on methylphenidate response but no association with DAT1-10R homozygosity in Dutch sibpairs with ADHD Oxford, UK Blackwell Publishing 2005 Online-Ressource nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Background: A minority of patients with attention-deficit hyperactivity disorder (ADHD) do not respond favorably to methylphenidate. This has been partially associated with homozygosity for the Dopamine transporter (DAT1) 10-repeat allele and the presence of one or two Dopamine D4 receptor (DRD4) 7-repeat alleles. This study examined the sibling correlation of methylphenidate response rate and the possible association between response rate and these risk alleles.Methods: A sample of 82 Dutch children with ADHD, from 54 families, (including 30 singletons and 28 sib pairs), who used methylphenidate, was phenotyped according to DSM-IV criteria. Patients were members of affected sib pairs and were genotyped for DAT1 and DRD4. The sibling Intraclass Correlation Coefficient for methylphenidate response rate was calculated. The association between individual response rates and the risk alleles was examined using linear regression techniques.Results: The Intraclass Correlation Coefficient was significant (r = .563, p = .001). No evidence was found establishing an association between methylphenidate response and DAT1-homozygosity. There was a positive trend towards association with the presence of one or two DRD4-7R alleles.Conclusions: The sibling correlation may indicate a familial clustering of methylphenidate response. This response is possibly associated with the presence of one or two alleles at the DRD4-7R locus, but not with DAT1-10R homozygosity in the Dutch population. 2005 Blackwell Publishing Journal Backfiles 1879-2005 |2005|||||||||| ADD/ADHD Bakker, Steven C. verfasserin aut Pauls, David L. verfasserin aut Oteman, Nicole oth Kruitwagen, Cas L.J.J. oth Pearson, Peter L. oth Sinke, Richard J. oth Buitelaar, Jan K. oth In The journal of child psychology and psychiatry Oxford : Wiley-Blackwell, 1960 46(2005), 10, Seite 0 Online-Ressource (DE-627)NLEJ243927568 (DE-600)1470297-6 1469-7610 nnns volume:46 year:2005 number:10 pages:0 http://dx.doi.org/10.1111/j.1469-7610.2005.01521.x text/html Verlag Deutschlandweit zugänglich Volltext GBV_USEFLAG_U ZDB-1-DJB GBV_NL_ARTICLE AR 46 2005 10 0 |
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10.1111/j.1469-7610.2005.01521.x doi (DE-627)NLEJ243309287 DE-627 ger DE-627 rakwb Meulen, Emma M. verfasserin aut High sibling correlation on methylphenidate response but no association with DAT1-10R homozygosity in Dutch sibpairs with ADHD Oxford, UK Blackwell Publishing 2005 Online-Ressource nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Background: A minority of patients with attention-deficit hyperactivity disorder (ADHD) do not respond favorably to methylphenidate. This has been partially associated with homozygosity for the Dopamine transporter (DAT1) 10-repeat allele and the presence of one or two Dopamine D4 receptor (DRD4) 7-repeat alleles. This study examined the sibling correlation of methylphenidate response rate and the possible association between response rate and these risk alleles.Methods: A sample of 82 Dutch children with ADHD, from 54 families, (including 30 singletons and 28 sib pairs), who used methylphenidate, was phenotyped according to DSM-IV criteria. Patients were members of affected sib pairs and were genotyped for DAT1 and DRD4. The sibling Intraclass Correlation Coefficient for methylphenidate response rate was calculated. The association between individual response rates and the risk alleles was examined using linear regression techniques.Results: The Intraclass Correlation Coefficient was significant (r = .563, p = .001). No evidence was found establishing an association between methylphenidate response and DAT1-homozygosity. There was a positive trend towards association with the presence of one or two DRD4-7R alleles.Conclusions: The sibling correlation may indicate a familial clustering of methylphenidate response. This response is possibly associated with the presence of one or two alleles at the DRD4-7R locus, but not with DAT1-10R homozygosity in the Dutch population. 2005 Blackwell Publishing Journal Backfiles 1879-2005 |2005|||||||||| ADD/ADHD Bakker, Steven C. verfasserin aut Pauls, David L. verfasserin aut Oteman, Nicole oth Kruitwagen, Cas L.J.J. oth Pearson, Peter L. oth Sinke, Richard J. oth Buitelaar, Jan K. oth In The journal of child psychology and psychiatry Oxford : Wiley-Blackwell, 1960 46(2005), 10, Seite 0 Online-Ressource (DE-627)NLEJ243927568 (DE-600)1470297-6 1469-7610 nnns volume:46 year:2005 number:10 pages:0 http://dx.doi.org/10.1111/j.1469-7610.2005.01521.x text/html Verlag Deutschlandweit zugänglich Volltext GBV_USEFLAG_U ZDB-1-DJB GBV_NL_ARTICLE AR 46 2005 10 0 |
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10.1111/j.1469-7610.2005.01521.x doi (DE-627)NLEJ243309287 DE-627 ger DE-627 rakwb Meulen, Emma M. verfasserin aut High sibling correlation on methylphenidate response but no association with DAT1-10R homozygosity in Dutch sibpairs with ADHD Oxford, UK Blackwell Publishing 2005 Online-Ressource nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Background: A minority of patients with attention-deficit hyperactivity disorder (ADHD) do not respond favorably to methylphenidate. This has been partially associated with homozygosity for the Dopamine transporter (DAT1) 10-repeat allele and the presence of one or two Dopamine D4 receptor (DRD4) 7-repeat alleles. This study examined the sibling correlation of methylphenidate response rate and the possible association between response rate and these risk alleles.Methods: A sample of 82 Dutch children with ADHD, from 54 families, (including 30 singletons and 28 sib pairs), who used methylphenidate, was phenotyped according to DSM-IV criteria. Patients were members of affected sib pairs and were genotyped for DAT1 and DRD4. The sibling Intraclass Correlation Coefficient for methylphenidate response rate was calculated. The association between individual response rates and the risk alleles was examined using linear regression techniques.Results: The Intraclass Correlation Coefficient was significant (r = .563, p = .001). No evidence was found establishing an association between methylphenidate response and DAT1-homozygosity. There was a positive trend towards association with the presence of one or two DRD4-7R alleles.Conclusions: The sibling correlation may indicate a familial clustering of methylphenidate response. This response is possibly associated with the presence of one or two alleles at the DRD4-7R locus, but not with DAT1-10R homozygosity in the Dutch population. 2005 Blackwell Publishing Journal Backfiles 1879-2005 |2005|||||||||| ADD/ADHD Bakker, Steven C. verfasserin aut Pauls, David L. verfasserin aut Oteman, Nicole oth Kruitwagen, Cas L.J.J. oth Pearson, Peter L. oth Sinke, Richard J. oth Buitelaar, Jan K. oth In The journal of child psychology and psychiatry Oxford : Wiley-Blackwell, 1960 46(2005), 10, Seite 0 Online-Ressource (DE-627)NLEJ243927568 (DE-600)1470297-6 1469-7610 nnns volume:46 year:2005 number:10 pages:0 http://dx.doi.org/10.1111/j.1469-7610.2005.01521.x text/html Verlag Deutschlandweit zugänglich Volltext GBV_USEFLAG_U ZDB-1-DJB GBV_NL_ARTICLE AR 46 2005 10 0 |
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10.1111/j.1469-7610.2005.01521.x doi (DE-627)NLEJ243309287 DE-627 ger DE-627 rakwb Meulen, Emma M. verfasserin aut High sibling correlation on methylphenidate response but no association with DAT1-10R homozygosity in Dutch sibpairs with ADHD Oxford, UK Blackwell Publishing 2005 Online-Ressource nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Background: A minority of patients with attention-deficit hyperactivity disorder (ADHD) do not respond favorably to methylphenidate. This has been partially associated with homozygosity for the Dopamine transporter (DAT1) 10-repeat allele and the presence of one or two Dopamine D4 receptor (DRD4) 7-repeat alleles. This study examined the sibling correlation of methylphenidate response rate and the possible association between response rate and these risk alleles.Methods: A sample of 82 Dutch children with ADHD, from 54 families, (including 30 singletons and 28 sib pairs), who used methylphenidate, was phenotyped according to DSM-IV criteria. Patients were members of affected sib pairs and were genotyped for DAT1 and DRD4. The sibling Intraclass Correlation Coefficient for methylphenidate response rate was calculated. The association between individual response rates and the risk alleles was examined using linear regression techniques.Results: The Intraclass Correlation Coefficient was significant (r = .563, p = .001). No evidence was found establishing an association between methylphenidate response and DAT1-homozygosity. There was a positive trend towards association with the presence of one or two DRD4-7R alleles.Conclusions: The sibling correlation may indicate a familial clustering of methylphenidate response. This response is possibly associated with the presence of one or two alleles at the DRD4-7R locus, but not with DAT1-10R homozygosity in the Dutch population. 2005 Blackwell Publishing Journal Backfiles 1879-2005 |2005|||||||||| ADD/ADHD Bakker, Steven C. verfasserin aut Pauls, David L. verfasserin aut Oteman, Nicole oth Kruitwagen, Cas L.J.J. oth Pearson, Peter L. oth Sinke, Richard J. oth Buitelaar, Jan K. oth In The journal of child psychology and psychiatry Oxford : Wiley-Blackwell, 1960 46(2005), 10, Seite 0 Online-Ressource (DE-627)NLEJ243927568 (DE-600)1470297-6 1469-7610 nnns volume:46 year:2005 number:10 pages:0 http://dx.doi.org/10.1111/j.1469-7610.2005.01521.x text/html Verlag Deutschlandweit zugänglich Volltext GBV_USEFLAG_U ZDB-1-DJB GBV_NL_ARTICLE AR 46 2005 10 0 |
| allfieldsSound |
10.1111/j.1469-7610.2005.01521.x doi (DE-627)NLEJ243309287 DE-627 ger DE-627 rakwb Meulen, Emma M. verfasserin aut High sibling correlation on methylphenidate response but no association with DAT1-10R homozygosity in Dutch sibpairs with ADHD Oxford, UK Blackwell Publishing 2005 Online-Ressource nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Background: A minority of patients with attention-deficit hyperactivity disorder (ADHD) do not respond favorably to methylphenidate. This has been partially associated with homozygosity for the Dopamine transporter (DAT1) 10-repeat allele and the presence of one or two Dopamine D4 receptor (DRD4) 7-repeat alleles. This study examined the sibling correlation of methylphenidate response rate and the possible association between response rate and these risk alleles.Methods: A sample of 82 Dutch children with ADHD, from 54 families, (including 30 singletons and 28 sib pairs), who used methylphenidate, was phenotyped according to DSM-IV criteria. Patients were members of affected sib pairs and were genotyped for DAT1 and DRD4. The sibling Intraclass Correlation Coefficient for methylphenidate response rate was calculated. The association between individual response rates and the risk alleles was examined using linear regression techniques.Results: The Intraclass Correlation Coefficient was significant (r = .563, p = .001). No evidence was found establishing an association between methylphenidate response and DAT1-homozygosity. There was a positive trend towards association with the presence of one or two DRD4-7R alleles.Conclusions: The sibling correlation may indicate a familial clustering of methylphenidate response. This response is possibly associated with the presence of one or two alleles at the DRD4-7R locus, but not with DAT1-10R homozygosity in the Dutch population. 2005 Blackwell Publishing Journal Backfiles 1879-2005 |2005|||||||||| ADD/ADHD Bakker, Steven C. verfasserin aut Pauls, David L. verfasserin aut Oteman, Nicole oth Kruitwagen, Cas L.J.J. oth Pearson, Peter L. oth Sinke, Richard J. oth Buitelaar, Jan K. oth In The journal of child psychology and psychiatry Oxford : Wiley-Blackwell, 1960 46(2005), 10, Seite 0 Online-Ressource (DE-627)NLEJ243927568 (DE-600)1470297-6 1469-7610 nnns volume:46 year:2005 number:10 pages:0 http://dx.doi.org/10.1111/j.1469-7610.2005.01521.x text/html Verlag Deutschlandweit zugänglich Volltext GBV_USEFLAG_U ZDB-1-DJB GBV_NL_ARTICLE AR 46 2005 10 0 |
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Meulen, Emma M. Bakker, Steven C. Pauls, David L. |
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Elektronische Aufsätze |
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Meulen, Emma M. |
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10.1111/j.1469-7610.2005.01521.x |
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high sibling correlation on methylphenidate response but no association with dat1-10r homozygosity in dutch sibpairs with adhd |
| title_auth |
High sibling correlation on methylphenidate response but no association with DAT1-10R homozygosity in Dutch sibpairs with ADHD |
| abstract |
Background: A minority of patients with attention-deficit hyperactivity disorder (ADHD) do not respond favorably to methylphenidate. This has been partially associated with homozygosity for the Dopamine transporter (DAT1) 10-repeat allele and the presence of one or two Dopamine D4 receptor (DRD4) 7-repeat alleles. This study examined the sibling correlation of methylphenidate response rate and the possible association between response rate and these risk alleles.Methods: A sample of 82 Dutch children with ADHD, from 54 families, (including 30 singletons and 28 sib pairs), who used methylphenidate, was phenotyped according to DSM-IV criteria. Patients were members of affected sib pairs and were genotyped for DAT1 and DRD4. The sibling Intraclass Correlation Coefficient for methylphenidate response rate was calculated. The association between individual response rates and the risk alleles was examined using linear regression techniques.Results: The Intraclass Correlation Coefficient was significant (r = .563, p = .001). No evidence was found establishing an association between methylphenidate response and DAT1-homozygosity. There was a positive trend towards association with the presence of one or two DRD4-7R alleles.Conclusions: The sibling correlation may indicate a familial clustering of methylphenidate response. This response is possibly associated with the presence of one or two alleles at the DRD4-7R locus, but not with DAT1-10R homozygosity in the Dutch population. |
| abstractGer |
Background: A minority of patients with attention-deficit hyperactivity disorder (ADHD) do not respond favorably to methylphenidate. This has been partially associated with homozygosity for the Dopamine transporter (DAT1) 10-repeat allele and the presence of one or two Dopamine D4 receptor (DRD4) 7-repeat alleles. This study examined the sibling correlation of methylphenidate response rate and the possible association between response rate and these risk alleles.Methods: A sample of 82 Dutch children with ADHD, from 54 families, (including 30 singletons and 28 sib pairs), who used methylphenidate, was phenotyped according to DSM-IV criteria. Patients were members of affected sib pairs and were genotyped for DAT1 and DRD4. The sibling Intraclass Correlation Coefficient for methylphenidate response rate was calculated. The association between individual response rates and the risk alleles was examined using linear regression techniques.Results: The Intraclass Correlation Coefficient was significant (r = .563, p = .001). No evidence was found establishing an association between methylphenidate response and DAT1-homozygosity. There was a positive trend towards association with the presence of one or two DRD4-7R alleles.Conclusions: The sibling correlation may indicate a familial clustering of methylphenidate response. This response is possibly associated with the presence of one or two alleles at the DRD4-7R locus, but not with DAT1-10R homozygosity in the Dutch population. |
| abstract_unstemmed |
Background: A minority of patients with attention-deficit hyperactivity disorder (ADHD) do not respond favorably to methylphenidate. This has been partially associated with homozygosity for the Dopamine transporter (DAT1) 10-repeat allele and the presence of one or two Dopamine D4 receptor (DRD4) 7-repeat alleles. This study examined the sibling correlation of methylphenidate response rate and the possible association between response rate and these risk alleles.Methods: A sample of 82 Dutch children with ADHD, from 54 families, (including 30 singletons and 28 sib pairs), who used methylphenidate, was phenotyped according to DSM-IV criteria. Patients were members of affected sib pairs and were genotyped for DAT1 and DRD4. The sibling Intraclass Correlation Coefficient for methylphenidate response rate was calculated. The association between individual response rates and the risk alleles was examined using linear regression techniques.Results: The Intraclass Correlation Coefficient was significant (r = .563, p = .001). No evidence was found establishing an association between methylphenidate response and DAT1-homozygosity. There was a positive trend towards association with the presence of one or two DRD4-7R alleles.Conclusions: The sibling correlation may indicate a familial clustering of methylphenidate response. This response is possibly associated with the presence of one or two alleles at the DRD4-7R locus, but not with DAT1-10R homozygosity in the Dutch population. |
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High sibling correlation on methylphenidate response but no association with DAT1-10R homozygosity in Dutch sibpairs with ADHD |
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Bakker, Steven C. Pauls, David L. Oteman, Nicole Kruitwagen, Cas L.J.J. Pearson, Peter L. Sinke, Richard J. Buitelaar, Jan K. |
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Bakker, Steven C. Pauls, David L. Oteman, Nicole Kruitwagen, Cas L.J.J. Pearson, Peter L. Sinke, Richard J. Buitelaar, Jan K. |
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