Introductory guide to the statistics of molecular genetics
Background: This introductory guide presents the main two analytical approaches used by molecular geneticists: linkage and association.Methods: Traditional linkage and association methods are described, along with more recent advances in methodologies such as those using a variance components appr...
Ausführliche Beschreibung
Gespeichert in:
| Autor*in: |
Eley, Thalia C. [verfasserIn] Rijsdijk, Frühling [verfasserIn] |
|---|
| Format: |
E-Artikel |
|---|
| Erschienen: |
Oxford, UK: Blackwell Publishing Ltd ; 2005 |
|---|
| Schlagwörter: |
|---|
| Umfang: |
Online-Ressource |
|---|
| Reproduktion: |
2005 ; Blackwell Publishing Journal Backfiles 1879-2005 |
|---|---|
| Übergeordnetes Werk: |
In: The journal of child psychology and psychiatry - Oxford : Wiley-Blackwell, 1960, 46(2005), 10, Seite 0 |
| Übergeordnetes Werk: |
volume:46 ; year:2005 ; number:10 ; pages:0 |
| Links: |
|---|
| DOI / URN: |
10.1111/j.1469-7610.2005.01523.x |
|---|
| Katalog-ID: |
NLEJ243309309 |
|---|
| LEADER | 01000caa a22002652 4500 | ||
|---|---|---|---|
| 001 | NLEJ243309309 | ||
| 003 | DE-627 | ||
| 005 | 20230506104106.0 | ||
| 007 | cr uuu---uuuuu | ||
| 008 | 120427s2005 xx |||||o 00| ||und c | ||
| 024 | 7 | |a 10.1111/j.1469-7610.2005.01523.x |2 doi | |
| 035 | |a (DE-627)NLEJ243309309 | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rakwb | ||
| 100 | 1 | |a Eley, Thalia C. |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a Introductory guide to the statistics of molecular genetics |
| 264 | 1 | |a Oxford, UK |b Blackwell Publishing Ltd |c 2005 | |
| 300 | |a Online-Ressource | ||
| 336 | |a nicht spezifiziert |b zzz |2 rdacontent | ||
| 337 | |a nicht spezifiziert |b z |2 rdamedia | ||
| 338 | |a nicht spezifiziert |b zu |2 rdacarrier | ||
| 520 | |a Background: This introductory guide presents the main two analytical approaches used by molecular geneticists: linkage and association.Methods: Traditional linkage and association methods are described, along with more recent advances in methodologies such as those using a variance components approach.Results: New methods are being developed all the time but the core principles of linkage and association remain the same. The basis of linkage is the transmission of a marker along with a disease within families, whereas association is based on the comparison of marker frequencies in case and control groups.Conclusions: It is becoming increasingly clear that effect sizes of individual markers on diseases and traits are likely to be very small. As such, much greater power is needed, and correspondingly greater sample sizes. Although non-replication is still a problem, molecular genetic studies in some areas such as attention deficit/hyperactivity disorder (ADHD) are starting to show greater convergence. Epidemiologists and other researchers with large well-characterized samples will be well placed to use these methods. Inter-disciplinary studies can then ask far more interesting questions such as those relating to developmental, multivariate and gene–environment interaction hypotheses. | ||
| 533 | |d 2005 |f Blackwell Publishing Journal Backfiles 1879-2005 |7 |2005|||||||||| | ||
| 650 | 4 | |a Quantitative trait loci (QTLs) | |
| 700 | 1 | |a Rijsdijk, Frühling |e verfasserin |4 aut | |
| 773 | 0 | 8 | |i In |t The journal of child psychology and psychiatry |d Oxford : Wiley-Blackwell, 1960 |g 46(2005), 10, Seite 0 |h Online-Ressource |w (DE-627)NLEJ243927568 |w (DE-600)1470297-6 |x 1469-7610 |7 nnns |
| 773 | 1 | 8 | |g volume:46 |g year:2005 |g number:10 |g pages:0 |
| 856 | 4 | 0 | |u http://dx.doi.org/10.1111/j.1469-7610.2005.01523.x |q text/html |x Verlag |z Deutschlandweit zugänglich |3 Volltext |
| 912 | |a GBV_USEFLAG_U | ||
| 912 | |a ZDB-1-DJB | ||
| 912 | |a GBV_NL_ARTICLE | ||
| 951 | |a AR | ||
| 952 | |d 46 |j 2005 |e 10 |h 0 | ||
| author_variant |
t c e tc tce f r fr |
|---|---|
| matchkey_str |
article:14697610:2005----::nrdcoyudttettsisfo |
| hierarchy_sort_str |
2005 |
| publishDate |
2005 |
| allfields |
10.1111/j.1469-7610.2005.01523.x doi (DE-627)NLEJ243309309 DE-627 ger DE-627 rakwb Eley, Thalia C. verfasserin aut Introductory guide to the statistics of molecular genetics Oxford, UK Blackwell Publishing Ltd 2005 Online-Ressource nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Background: This introductory guide presents the main two analytical approaches used by molecular geneticists: linkage and association.Methods: Traditional linkage and association methods are described, along with more recent advances in methodologies such as those using a variance components approach.Results: New methods are being developed all the time but the core principles of linkage and association remain the same. The basis of linkage is the transmission of a marker along with a disease within families, whereas association is based on the comparison of marker frequencies in case and control groups.Conclusions: It is becoming increasingly clear that effect sizes of individual markers on diseases and traits are likely to be very small. As such, much greater power is needed, and correspondingly greater sample sizes. Although non-replication is still a problem, molecular genetic studies in some areas such as attention deficit/hyperactivity disorder (ADHD) are starting to show greater convergence. Epidemiologists and other researchers with large well-characterized samples will be well placed to use these methods. Inter-disciplinary studies can then ask far more interesting questions such as those relating to developmental, multivariate and gene–environment interaction hypotheses. 2005 Blackwell Publishing Journal Backfiles 1879-2005 |2005|||||||||| Quantitative trait loci (QTLs) Rijsdijk, Frühling verfasserin aut In The journal of child psychology and psychiatry Oxford : Wiley-Blackwell, 1960 46(2005), 10, Seite 0 Online-Ressource (DE-627)NLEJ243927568 (DE-600)1470297-6 1469-7610 nnns volume:46 year:2005 number:10 pages:0 http://dx.doi.org/10.1111/j.1469-7610.2005.01523.x text/html Verlag Deutschlandweit zugänglich Volltext GBV_USEFLAG_U ZDB-1-DJB GBV_NL_ARTICLE AR 46 2005 10 0 |
| spelling |
10.1111/j.1469-7610.2005.01523.x doi (DE-627)NLEJ243309309 DE-627 ger DE-627 rakwb Eley, Thalia C. verfasserin aut Introductory guide to the statistics of molecular genetics Oxford, UK Blackwell Publishing Ltd 2005 Online-Ressource nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Background: This introductory guide presents the main two analytical approaches used by molecular geneticists: linkage and association.Methods: Traditional linkage and association methods are described, along with more recent advances in methodologies such as those using a variance components approach.Results: New methods are being developed all the time but the core principles of linkage and association remain the same. The basis of linkage is the transmission of a marker along with a disease within families, whereas association is based on the comparison of marker frequencies in case and control groups.Conclusions: It is becoming increasingly clear that effect sizes of individual markers on diseases and traits are likely to be very small. As such, much greater power is needed, and correspondingly greater sample sizes. Although non-replication is still a problem, molecular genetic studies in some areas such as attention deficit/hyperactivity disorder (ADHD) are starting to show greater convergence. Epidemiologists and other researchers with large well-characterized samples will be well placed to use these methods. Inter-disciplinary studies can then ask far more interesting questions such as those relating to developmental, multivariate and gene–environment interaction hypotheses. 2005 Blackwell Publishing Journal Backfiles 1879-2005 |2005|||||||||| Quantitative trait loci (QTLs) Rijsdijk, Frühling verfasserin aut In The journal of child psychology and psychiatry Oxford : Wiley-Blackwell, 1960 46(2005), 10, Seite 0 Online-Ressource (DE-627)NLEJ243927568 (DE-600)1470297-6 1469-7610 nnns volume:46 year:2005 number:10 pages:0 http://dx.doi.org/10.1111/j.1469-7610.2005.01523.x text/html Verlag Deutschlandweit zugänglich Volltext GBV_USEFLAG_U ZDB-1-DJB GBV_NL_ARTICLE AR 46 2005 10 0 |
| allfields_unstemmed |
10.1111/j.1469-7610.2005.01523.x doi (DE-627)NLEJ243309309 DE-627 ger DE-627 rakwb Eley, Thalia C. verfasserin aut Introductory guide to the statistics of molecular genetics Oxford, UK Blackwell Publishing Ltd 2005 Online-Ressource nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Background: This introductory guide presents the main two analytical approaches used by molecular geneticists: linkage and association.Methods: Traditional linkage and association methods are described, along with more recent advances in methodologies such as those using a variance components approach.Results: New methods are being developed all the time but the core principles of linkage and association remain the same. The basis of linkage is the transmission of a marker along with a disease within families, whereas association is based on the comparison of marker frequencies in case and control groups.Conclusions: It is becoming increasingly clear that effect sizes of individual markers on diseases and traits are likely to be very small. As such, much greater power is needed, and correspondingly greater sample sizes. Although non-replication is still a problem, molecular genetic studies in some areas such as attention deficit/hyperactivity disorder (ADHD) are starting to show greater convergence. Epidemiologists and other researchers with large well-characterized samples will be well placed to use these methods. Inter-disciplinary studies can then ask far more interesting questions such as those relating to developmental, multivariate and gene–environment interaction hypotheses. 2005 Blackwell Publishing Journal Backfiles 1879-2005 |2005|||||||||| Quantitative trait loci (QTLs) Rijsdijk, Frühling verfasserin aut In The journal of child psychology and psychiatry Oxford : Wiley-Blackwell, 1960 46(2005), 10, Seite 0 Online-Ressource (DE-627)NLEJ243927568 (DE-600)1470297-6 1469-7610 nnns volume:46 year:2005 number:10 pages:0 http://dx.doi.org/10.1111/j.1469-7610.2005.01523.x text/html Verlag Deutschlandweit zugänglich Volltext GBV_USEFLAG_U ZDB-1-DJB GBV_NL_ARTICLE AR 46 2005 10 0 |
| allfieldsGer |
10.1111/j.1469-7610.2005.01523.x doi (DE-627)NLEJ243309309 DE-627 ger DE-627 rakwb Eley, Thalia C. verfasserin aut Introductory guide to the statistics of molecular genetics Oxford, UK Blackwell Publishing Ltd 2005 Online-Ressource nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Background: This introductory guide presents the main two analytical approaches used by molecular geneticists: linkage and association.Methods: Traditional linkage and association methods are described, along with more recent advances in methodologies such as those using a variance components approach.Results: New methods are being developed all the time but the core principles of linkage and association remain the same. The basis of linkage is the transmission of a marker along with a disease within families, whereas association is based on the comparison of marker frequencies in case and control groups.Conclusions: It is becoming increasingly clear that effect sizes of individual markers on diseases and traits are likely to be very small. As such, much greater power is needed, and correspondingly greater sample sizes. Although non-replication is still a problem, molecular genetic studies in some areas such as attention deficit/hyperactivity disorder (ADHD) are starting to show greater convergence. Epidemiologists and other researchers with large well-characterized samples will be well placed to use these methods. Inter-disciplinary studies can then ask far more interesting questions such as those relating to developmental, multivariate and gene–environment interaction hypotheses. 2005 Blackwell Publishing Journal Backfiles 1879-2005 |2005|||||||||| Quantitative trait loci (QTLs) Rijsdijk, Frühling verfasserin aut In The journal of child psychology and psychiatry Oxford : Wiley-Blackwell, 1960 46(2005), 10, Seite 0 Online-Ressource (DE-627)NLEJ243927568 (DE-600)1470297-6 1469-7610 nnns volume:46 year:2005 number:10 pages:0 http://dx.doi.org/10.1111/j.1469-7610.2005.01523.x text/html Verlag Deutschlandweit zugänglich Volltext GBV_USEFLAG_U ZDB-1-DJB GBV_NL_ARTICLE AR 46 2005 10 0 |
| allfieldsSound |
10.1111/j.1469-7610.2005.01523.x doi (DE-627)NLEJ243309309 DE-627 ger DE-627 rakwb Eley, Thalia C. verfasserin aut Introductory guide to the statistics of molecular genetics Oxford, UK Blackwell Publishing Ltd 2005 Online-Ressource nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Background: This introductory guide presents the main two analytical approaches used by molecular geneticists: linkage and association.Methods: Traditional linkage and association methods are described, along with more recent advances in methodologies such as those using a variance components approach.Results: New methods are being developed all the time but the core principles of linkage and association remain the same. The basis of linkage is the transmission of a marker along with a disease within families, whereas association is based on the comparison of marker frequencies in case and control groups.Conclusions: It is becoming increasingly clear that effect sizes of individual markers on diseases and traits are likely to be very small. As such, much greater power is needed, and correspondingly greater sample sizes. Although non-replication is still a problem, molecular genetic studies in some areas such as attention deficit/hyperactivity disorder (ADHD) are starting to show greater convergence. Epidemiologists and other researchers with large well-characterized samples will be well placed to use these methods. Inter-disciplinary studies can then ask far more interesting questions such as those relating to developmental, multivariate and gene–environment interaction hypotheses. 2005 Blackwell Publishing Journal Backfiles 1879-2005 |2005|||||||||| Quantitative trait loci (QTLs) Rijsdijk, Frühling verfasserin aut In The journal of child psychology and psychiatry Oxford : Wiley-Blackwell, 1960 46(2005), 10, Seite 0 Online-Ressource (DE-627)NLEJ243927568 (DE-600)1470297-6 1469-7610 nnns volume:46 year:2005 number:10 pages:0 http://dx.doi.org/10.1111/j.1469-7610.2005.01523.x text/html Verlag Deutschlandweit zugänglich Volltext GBV_USEFLAG_U ZDB-1-DJB GBV_NL_ARTICLE AR 46 2005 10 0 |
| source |
In The journal of child psychology and psychiatry 46(2005), 10, Seite 0 volume:46 year:2005 number:10 pages:0 |
| sourceStr |
In The journal of child psychology and psychiatry 46(2005), 10, Seite 0 volume:46 year:2005 number:10 pages:0 |
| format_phy_str_mv |
Article |
| institution |
findex.gbv.de |
| topic_facet |
Quantitative trait loci (QTLs) |
| isfreeaccess_bool |
false |
| container_title |
The journal of child psychology and psychiatry |
| authorswithroles_txt_mv |
Eley, Thalia C. @@aut@@ Rijsdijk, Frühling @@aut@@ |
| publishDateDaySort_date |
2005-01-01T00:00:00Z |
| hierarchy_top_id |
NLEJ243927568 |
| id |
NLEJ243309309 |
| fullrecord |
<?xml version="1.0" encoding="UTF-8"?><collection xmlns="http://www.loc.gov/MARC21/slim"><record><leader>01000caa a22002652 4500</leader><controlfield tag="001">NLEJ243309309</controlfield><controlfield tag="003">DE-627</controlfield><controlfield tag="005">20230506104106.0</controlfield><controlfield tag="007">cr uuu---uuuuu</controlfield><controlfield tag="008">120427s2005 xx |||||o 00| ||und c</controlfield><datafield tag="024" ind1="7" ind2=" "><subfield code="a">10.1111/j.1469-7610.2005.01523.x</subfield><subfield code="2">doi</subfield></datafield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(DE-627)NLEJ243309309</subfield></datafield><datafield tag="040" ind1=" " ind2=" "><subfield code="a">DE-627</subfield><subfield code="b">ger</subfield><subfield code="c">DE-627</subfield><subfield code="e">rakwb</subfield></datafield><datafield tag="100" ind1="1" ind2=" "><subfield code="a">Eley, Thalia C.</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="245" ind1="1" ind2="0"><subfield code="a">Introductory guide to the statistics of molecular genetics</subfield></datafield><datafield tag="264" ind1=" " ind2="1"><subfield code="a">Oxford, UK</subfield><subfield code="b">Blackwell Publishing Ltd</subfield><subfield code="c">2005</subfield></datafield><datafield tag="300" ind1=" " ind2=" "><subfield code="a">Online-Ressource</subfield></datafield><datafield tag="336" ind1=" " ind2=" "><subfield code="a">nicht spezifiziert</subfield><subfield code="b">zzz</subfield><subfield code="2">rdacontent</subfield></datafield><datafield tag="337" ind1=" " ind2=" "><subfield code="a">nicht spezifiziert</subfield><subfield code="b">z</subfield><subfield code="2">rdamedia</subfield></datafield><datafield tag="338" ind1=" " ind2=" "><subfield code="a">nicht spezifiziert</subfield><subfield code="b">zu</subfield><subfield code="2">rdacarrier</subfield></datafield><datafield tag="520" ind1=" " ind2=" "><subfield code="a">Background: This introductory guide presents the main two analytical approaches used by molecular geneticists: linkage and association.Methods: Traditional linkage and association methods are described, along with more recent advances in methodologies such as those using a variance components approach.Results: New methods are being developed all the time but the core principles of linkage and association remain the same. The basis of linkage is the transmission of a marker along with a disease within families, whereas association is based on the comparison of marker frequencies in case and control groups.Conclusions: It is becoming increasingly clear that effect sizes of individual markers on diseases and traits are likely to be very small. As such, much greater power is needed, and correspondingly greater sample sizes. Although non-replication is still a problem, molecular genetic studies in some areas such as attention deficit/hyperactivity disorder (ADHD) are starting to show greater convergence. Epidemiologists and other researchers with large well-characterized samples will be well placed to use these methods. Inter-disciplinary studies can then ask far more interesting questions such as those relating to developmental, multivariate and gene–environment interaction hypotheses.</subfield></datafield><datafield tag="533" ind1=" " ind2=" "><subfield code="d">2005</subfield><subfield code="f">Blackwell Publishing Journal Backfiles 1879-2005</subfield><subfield code="7">|2005||||||||||</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Quantitative trait loci (QTLs)</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Rijsdijk, Frühling</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="773" ind1="0" ind2="8"><subfield code="i">In</subfield><subfield code="t">The journal of child psychology and psychiatry</subfield><subfield code="d">Oxford : Wiley-Blackwell, 1960</subfield><subfield code="g">46(2005), 10, Seite 0</subfield><subfield code="h">Online-Ressource</subfield><subfield code="w">(DE-627)NLEJ243927568</subfield><subfield code="w">(DE-600)1470297-6</subfield><subfield code="x">1469-7610</subfield><subfield code="7">nnns</subfield></datafield><datafield tag="773" ind1="1" ind2="8"><subfield code="g">volume:46</subfield><subfield code="g">year:2005</subfield><subfield code="g">number:10</subfield><subfield code="g">pages:0</subfield></datafield><datafield tag="856" ind1="4" ind2="0"><subfield code="u">http://dx.doi.org/10.1111/j.1469-7610.2005.01523.x</subfield><subfield code="q">text/html</subfield><subfield code="x">Verlag</subfield><subfield code="z">Deutschlandweit zugänglich</subfield><subfield code="3">Volltext</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_USEFLAG_U</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">ZDB-1-DJB</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_NL_ARTICLE</subfield></datafield><datafield tag="951" ind1=" " ind2=" "><subfield code="a">AR</subfield></datafield><datafield tag="952" ind1=" " ind2=" "><subfield code="d">46</subfield><subfield code="j">2005</subfield><subfield code="e">10</subfield><subfield code="h">0</subfield></datafield></record></collection>
|
| series2 |
Blackwell Publishing Journal Backfiles 1879-2005 |
| author |
Eley, Thalia C. |
| spellingShingle |
Eley, Thalia C. misc Quantitative trait loci (QTLs) Introductory guide to the statistics of molecular genetics |
| authorStr |
Eley, Thalia C. |
| ppnlink_with_tag_str_mv |
@@773@@(DE-627)NLEJ243927568 |
| format |
electronic Article |
| delete_txt_mv |
keep |
| author_role |
aut aut |
| collection |
NL |
| publishPlace |
Oxford, UK |
| remote_str |
true |
| illustrated |
Not Illustrated |
| issn |
1469-7610 |
| topic_title |
Introductory guide to the statistics of molecular genetics Quantitative trait loci (QTLs) |
| publisher |
Blackwell Publishing Ltd |
| publisherStr |
Blackwell Publishing Ltd |
| topic |
misc Quantitative trait loci (QTLs) |
| topic_unstemmed |
misc Quantitative trait loci (QTLs) |
| topic_browse |
misc Quantitative trait loci (QTLs) |
| format_facet |
Elektronische Aufsätze Aufsätze Elektronische Ressource |
| format_main_str_mv |
Text Zeitschrift/Artikel |
| carriertype_str_mv |
zu |
| hierarchy_parent_title |
The journal of child psychology and psychiatry |
| hierarchy_parent_id |
NLEJ243927568 |
| hierarchy_top_title |
The journal of child psychology and psychiatry |
| isfreeaccess_txt |
false |
| familylinks_str_mv |
(DE-627)NLEJ243927568 (DE-600)1470297-6 |
| title |
Introductory guide to the statistics of molecular genetics |
| ctrlnum |
(DE-627)NLEJ243309309 |
| title_full |
Introductory guide to the statistics of molecular genetics |
| author_sort |
Eley, Thalia C. |
| journal |
The journal of child psychology and psychiatry |
| journalStr |
The journal of child psychology and psychiatry |
| isOA_bool |
false |
| recordtype |
marc |
| publishDateSort |
2005 |
| contenttype_str_mv |
zzz |
| container_start_page |
0 |
| author_browse |
Eley, Thalia C. Rijsdijk, Frühling |
| container_volume |
46 |
| physical |
Online-Ressource |
| format_se |
Elektronische Aufsätze |
| author-letter |
Eley, Thalia C. |
| doi_str_mv |
10.1111/j.1469-7610.2005.01523.x |
| author2-role |
verfasserin |
| title_sort |
introductory guide to the statistics of molecular genetics |
| title_auth |
Introductory guide to the statistics of molecular genetics |
| abstract |
Background: This introductory guide presents the main two analytical approaches used by molecular geneticists: linkage and association.Methods: Traditional linkage and association methods are described, along with more recent advances in methodologies such as those using a variance components approach.Results: New methods are being developed all the time but the core principles of linkage and association remain the same. The basis of linkage is the transmission of a marker along with a disease within families, whereas association is based on the comparison of marker frequencies in case and control groups.Conclusions: It is becoming increasingly clear that effect sizes of individual markers on diseases and traits are likely to be very small. As such, much greater power is needed, and correspondingly greater sample sizes. Although non-replication is still a problem, molecular genetic studies in some areas such as attention deficit/hyperactivity disorder (ADHD) are starting to show greater convergence. Epidemiologists and other researchers with large well-characterized samples will be well placed to use these methods. Inter-disciplinary studies can then ask far more interesting questions such as those relating to developmental, multivariate and gene–environment interaction hypotheses. |
| abstractGer |
Background: This introductory guide presents the main two analytical approaches used by molecular geneticists: linkage and association.Methods: Traditional linkage and association methods are described, along with more recent advances in methodologies such as those using a variance components approach.Results: New methods are being developed all the time but the core principles of linkage and association remain the same. The basis of linkage is the transmission of a marker along with a disease within families, whereas association is based on the comparison of marker frequencies in case and control groups.Conclusions: It is becoming increasingly clear that effect sizes of individual markers on diseases and traits are likely to be very small. As such, much greater power is needed, and correspondingly greater sample sizes. Although non-replication is still a problem, molecular genetic studies in some areas such as attention deficit/hyperactivity disorder (ADHD) are starting to show greater convergence. Epidemiologists and other researchers with large well-characterized samples will be well placed to use these methods. Inter-disciplinary studies can then ask far more interesting questions such as those relating to developmental, multivariate and gene–environment interaction hypotheses. |
| abstract_unstemmed |
Background: This introductory guide presents the main two analytical approaches used by molecular geneticists: linkage and association.Methods: Traditional linkage and association methods are described, along with more recent advances in methodologies such as those using a variance components approach.Results: New methods are being developed all the time but the core principles of linkage and association remain the same. The basis of linkage is the transmission of a marker along with a disease within families, whereas association is based on the comparison of marker frequencies in case and control groups.Conclusions: It is becoming increasingly clear that effect sizes of individual markers on diseases and traits are likely to be very small. As such, much greater power is needed, and correspondingly greater sample sizes. Although non-replication is still a problem, molecular genetic studies in some areas such as attention deficit/hyperactivity disorder (ADHD) are starting to show greater convergence. Epidemiologists and other researchers with large well-characterized samples will be well placed to use these methods. Inter-disciplinary studies can then ask far more interesting questions such as those relating to developmental, multivariate and gene–environment interaction hypotheses. |
| collection_details |
GBV_USEFLAG_U ZDB-1-DJB GBV_NL_ARTICLE |
| container_issue |
10 |
| title_short |
Introductory guide to the statistics of molecular genetics |
| url |
http://dx.doi.org/10.1111/j.1469-7610.2005.01523.x |
| remote_bool |
true |
| author2 |
Rijsdijk, Frühling |
| author2Str |
Rijsdijk, Frühling |
| ppnlink |
NLEJ243927568 |
| mediatype_str_mv |
z |
| isOA_txt |
false |
| hochschulschrift_bool |
false |
| doi_str |
10.1111/j.1469-7610.2005.01523.x |
| up_date |
2024-07-06T05:01:35.004Z |
| _version_ |
1803804575009865728 |
| fullrecord_marcxml |
<?xml version="1.0" encoding="UTF-8"?><collection xmlns="http://www.loc.gov/MARC21/slim"><record><leader>01000caa a22002652 4500</leader><controlfield tag="001">NLEJ243309309</controlfield><controlfield tag="003">DE-627</controlfield><controlfield tag="005">20230506104106.0</controlfield><controlfield tag="007">cr uuu---uuuuu</controlfield><controlfield tag="008">120427s2005 xx |||||o 00| ||und c</controlfield><datafield tag="024" ind1="7" ind2=" "><subfield code="a">10.1111/j.1469-7610.2005.01523.x</subfield><subfield code="2">doi</subfield></datafield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(DE-627)NLEJ243309309</subfield></datafield><datafield tag="040" ind1=" " ind2=" "><subfield code="a">DE-627</subfield><subfield code="b">ger</subfield><subfield code="c">DE-627</subfield><subfield code="e">rakwb</subfield></datafield><datafield tag="100" ind1="1" ind2=" "><subfield code="a">Eley, Thalia C.</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="245" ind1="1" ind2="0"><subfield code="a">Introductory guide to the statistics of molecular genetics</subfield></datafield><datafield tag="264" ind1=" " ind2="1"><subfield code="a">Oxford, UK</subfield><subfield code="b">Blackwell Publishing Ltd</subfield><subfield code="c">2005</subfield></datafield><datafield tag="300" ind1=" " ind2=" "><subfield code="a">Online-Ressource</subfield></datafield><datafield tag="336" ind1=" " ind2=" "><subfield code="a">nicht spezifiziert</subfield><subfield code="b">zzz</subfield><subfield code="2">rdacontent</subfield></datafield><datafield tag="337" ind1=" " ind2=" "><subfield code="a">nicht spezifiziert</subfield><subfield code="b">z</subfield><subfield code="2">rdamedia</subfield></datafield><datafield tag="338" ind1=" " ind2=" "><subfield code="a">nicht spezifiziert</subfield><subfield code="b">zu</subfield><subfield code="2">rdacarrier</subfield></datafield><datafield tag="520" ind1=" " ind2=" "><subfield code="a">Background: This introductory guide presents the main two analytical approaches used by molecular geneticists: linkage and association.Methods: Traditional linkage and association methods are described, along with more recent advances in methodologies such as those using a variance components approach.Results: New methods are being developed all the time but the core principles of linkage and association remain the same. The basis of linkage is the transmission of a marker along with a disease within families, whereas association is based on the comparison of marker frequencies in case and control groups.Conclusions: It is becoming increasingly clear that effect sizes of individual markers on diseases and traits are likely to be very small. As such, much greater power is needed, and correspondingly greater sample sizes. Although non-replication is still a problem, molecular genetic studies in some areas such as attention deficit/hyperactivity disorder (ADHD) are starting to show greater convergence. Epidemiologists and other researchers with large well-characterized samples will be well placed to use these methods. Inter-disciplinary studies can then ask far more interesting questions such as those relating to developmental, multivariate and gene–environment interaction hypotheses.</subfield></datafield><datafield tag="533" ind1=" " ind2=" "><subfield code="d">2005</subfield><subfield code="f">Blackwell Publishing Journal Backfiles 1879-2005</subfield><subfield code="7">|2005||||||||||</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Quantitative trait loci (QTLs)</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Rijsdijk, Frühling</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="773" ind1="0" ind2="8"><subfield code="i">In</subfield><subfield code="t">The journal of child psychology and psychiatry</subfield><subfield code="d">Oxford : Wiley-Blackwell, 1960</subfield><subfield code="g">46(2005), 10, Seite 0</subfield><subfield code="h">Online-Ressource</subfield><subfield code="w">(DE-627)NLEJ243927568</subfield><subfield code="w">(DE-600)1470297-6</subfield><subfield code="x">1469-7610</subfield><subfield code="7">nnns</subfield></datafield><datafield tag="773" ind1="1" ind2="8"><subfield code="g">volume:46</subfield><subfield code="g">year:2005</subfield><subfield code="g">number:10</subfield><subfield code="g">pages:0</subfield></datafield><datafield tag="856" ind1="4" ind2="0"><subfield code="u">http://dx.doi.org/10.1111/j.1469-7610.2005.01523.x</subfield><subfield code="q">text/html</subfield><subfield code="x">Verlag</subfield><subfield code="z">Deutschlandweit zugänglich</subfield><subfield code="3">Volltext</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_USEFLAG_U</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">ZDB-1-DJB</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_NL_ARTICLE</subfield></datafield><datafield tag="951" ind1=" " ind2=" "><subfield code="a">AR</subfield></datafield><datafield tag="952" ind1=" " ind2=" "><subfield code="d">46</subfield><subfield code="j">2005</subfield><subfield code="e">10</subfield><subfield code="h">0</subfield></datafield></record></collection>
|
| score |
7.3987713 |