Finding genes in child psychology and psychiatry: When are we going to be there?
Background: The seven papers in this special section chart where we are in the quest for quantitative trait loci (QTLs) in key areas of child psychology and psychiatry such as reading and hyperactivity. But we are not there yet.Methods: This commentary considers some new developments that are like...
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Plomin, Robert [verfasserIn] |
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Oxford, UK: Blackwell Publishing Ltd ; 2005 |
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Online-Ressource |
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2005 ; Blackwell Publishing Journal Backfiles 1879-2005 |
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In: The journal of child psychology and psychiatry - Oxford : Wiley-Blackwell, 1960, 46(2005), 10, Seite 0 |
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volume:46 ; year:2005 ; number:10 ; pages:0 |
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10.1111/j.1469-7610.2005.01524.x |
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| 520 | |a Background: The seven papers in this special section chart where we are in the quest for quantitative trait loci (QTLs) in key areas of child psychology and psychiatry such as reading and hyperactivity. But we are not there yet.Methods: This commentary considers some new developments that are likely to accelerate the journey towards the identification of QTLs.Results: The single most important factor is the need for very large samples to attain adequate power to detect and replicate QTLs of very small effect size. Another important development is the microarray, which makes it possible to genotype hundreds of thousands of SNPs simultaneously. Using microarrays in association studies allows SNPs across the whole genome to be genotyped. Microarrays will boost power even more when they contain all functional polymorphisms in the genome, including functional non-coding DNA.Conclusions: Once replicable QTLs are identified in areas such as reading and hyperactivity, the real journey will begin. Future studies will use sets of QTLs as genetic risk indicators in top-down behavioural genomic research, leading to gene-based diagnoses, gene-based treatments tailored to the individual, and early warning systems and interventions. These discoveries will eventually help to prevent or at least ameliorate childhood disorders before they cast their long shadow over development. | ||
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10.1111/j.1469-7610.2005.01524.x doi (DE-627)NLEJ243309317 DE-627 ger DE-627 rakwb Plomin, Robert verfasserin aut Finding genes in child psychology and psychiatry: When are we going to be there? Oxford, UK Blackwell Publishing Ltd 2005 Online-Ressource nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Background: The seven papers in this special section chart where we are in the quest for quantitative trait loci (QTLs) in key areas of child psychology and psychiatry such as reading and hyperactivity. But we are not there yet.Methods: This commentary considers some new developments that are likely to accelerate the journey towards the identification of QTLs.Results: The single most important factor is the need for very large samples to attain adequate power to detect and replicate QTLs of very small effect size. Another important development is the microarray, which makes it possible to genotype hundreds of thousands of SNPs simultaneously. Using microarrays in association studies allows SNPs across the whole genome to be genotyped. Microarrays will boost power even more when they contain all functional polymorphisms in the genome, including functional non-coding DNA.Conclusions: Once replicable QTLs are identified in areas such as reading and hyperactivity, the real journey will begin. Future studies will use sets of QTLs as genetic risk indicators in top-down behavioural genomic research, leading to gene-based diagnoses, gene-based treatments tailored to the individual, and early warning systems and interventions. These discoveries will eventually help to prevent or at least ameliorate childhood disorders before they cast their long shadow over development. 2005 Blackwell Publishing Journal Backfiles 1879-2005 |2005|||||||||| QTLs In The journal of child psychology and psychiatry Oxford : Wiley-Blackwell, 1960 46(2005), 10, Seite 0 Online-Ressource (DE-627)NLEJ243927568 (DE-600)1470297-6 1469-7610 nnns volume:46 year:2005 number:10 pages:0 http://dx.doi.org/10.1111/j.1469-7610.2005.01524.x text/html Verlag Deutschlandweit zugänglich Volltext GBV_USEFLAG_U ZDB-1-DJB GBV_NL_ARTICLE AR 46 2005 10 0 |
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10.1111/j.1469-7610.2005.01524.x doi (DE-627)NLEJ243309317 DE-627 ger DE-627 rakwb Plomin, Robert verfasserin aut Finding genes in child psychology and psychiatry: When are we going to be there? Oxford, UK Blackwell Publishing Ltd 2005 Online-Ressource nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Background: The seven papers in this special section chart where we are in the quest for quantitative trait loci (QTLs) in key areas of child psychology and psychiatry such as reading and hyperactivity. But we are not there yet.Methods: This commentary considers some new developments that are likely to accelerate the journey towards the identification of QTLs.Results: The single most important factor is the need for very large samples to attain adequate power to detect and replicate QTLs of very small effect size. Another important development is the microarray, which makes it possible to genotype hundreds of thousands of SNPs simultaneously. Using microarrays in association studies allows SNPs across the whole genome to be genotyped. Microarrays will boost power even more when they contain all functional polymorphisms in the genome, including functional non-coding DNA.Conclusions: Once replicable QTLs are identified in areas such as reading and hyperactivity, the real journey will begin. Future studies will use sets of QTLs as genetic risk indicators in top-down behavioural genomic research, leading to gene-based diagnoses, gene-based treatments tailored to the individual, and early warning systems and interventions. These discoveries will eventually help to prevent or at least ameliorate childhood disorders before they cast their long shadow over development. 2005 Blackwell Publishing Journal Backfiles 1879-2005 |2005|||||||||| QTLs In The journal of child psychology and psychiatry Oxford : Wiley-Blackwell, 1960 46(2005), 10, Seite 0 Online-Ressource (DE-627)NLEJ243927568 (DE-600)1470297-6 1469-7610 nnns volume:46 year:2005 number:10 pages:0 http://dx.doi.org/10.1111/j.1469-7610.2005.01524.x text/html Verlag Deutschlandweit zugänglich Volltext GBV_USEFLAG_U ZDB-1-DJB GBV_NL_ARTICLE AR 46 2005 10 0 |
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10.1111/j.1469-7610.2005.01524.x doi (DE-627)NLEJ243309317 DE-627 ger DE-627 rakwb Plomin, Robert verfasserin aut Finding genes in child psychology and psychiatry: When are we going to be there? Oxford, UK Blackwell Publishing Ltd 2005 Online-Ressource nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Background: The seven papers in this special section chart where we are in the quest for quantitative trait loci (QTLs) in key areas of child psychology and psychiatry such as reading and hyperactivity. But we are not there yet.Methods: This commentary considers some new developments that are likely to accelerate the journey towards the identification of QTLs.Results: The single most important factor is the need for very large samples to attain adequate power to detect and replicate QTLs of very small effect size. Another important development is the microarray, which makes it possible to genotype hundreds of thousands of SNPs simultaneously. Using microarrays in association studies allows SNPs across the whole genome to be genotyped. Microarrays will boost power even more when they contain all functional polymorphisms in the genome, including functional non-coding DNA.Conclusions: Once replicable QTLs are identified in areas such as reading and hyperactivity, the real journey will begin. Future studies will use sets of QTLs as genetic risk indicators in top-down behavioural genomic research, leading to gene-based diagnoses, gene-based treatments tailored to the individual, and early warning systems and interventions. These discoveries will eventually help to prevent or at least ameliorate childhood disorders before they cast their long shadow over development. 2005 Blackwell Publishing Journal Backfiles 1879-2005 |2005|||||||||| QTLs In The journal of child psychology and psychiatry Oxford : Wiley-Blackwell, 1960 46(2005), 10, Seite 0 Online-Ressource (DE-627)NLEJ243927568 (DE-600)1470297-6 1469-7610 nnns volume:46 year:2005 number:10 pages:0 http://dx.doi.org/10.1111/j.1469-7610.2005.01524.x text/html Verlag Deutschlandweit zugänglich Volltext GBV_USEFLAG_U ZDB-1-DJB GBV_NL_ARTICLE AR 46 2005 10 0 |
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10.1111/j.1469-7610.2005.01524.x doi (DE-627)NLEJ243309317 DE-627 ger DE-627 rakwb Plomin, Robert verfasserin aut Finding genes in child psychology and psychiatry: When are we going to be there? Oxford, UK Blackwell Publishing Ltd 2005 Online-Ressource nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Background: The seven papers in this special section chart where we are in the quest for quantitative trait loci (QTLs) in key areas of child psychology and psychiatry such as reading and hyperactivity. But we are not there yet.Methods: This commentary considers some new developments that are likely to accelerate the journey towards the identification of QTLs.Results: The single most important factor is the need for very large samples to attain adequate power to detect and replicate QTLs of very small effect size. Another important development is the microarray, which makes it possible to genotype hundreds of thousands of SNPs simultaneously. Using microarrays in association studies allows SNPs across the whole genome to be genotyped. Microarrays will boost power even more when they contain all functional polymorphisms in the genome, including functional non-coding DNA.Conclusions: Once replicable QTLs are identified in areas such as reading and hyperactivity, the real journey will begin. Future studies will use sets of QTLs as genetic risk indicators in top-down behavioural genomic research, leading to gene-based diagnoses, gene-based treatments tailored to the individual, and early warning systems and interventions. These discoveries will eventually help to prevent or at least ameliorate childhood disorders before they cast their long shadow over development. 2005 Blackwell Publishing Journal Backfiles 1879-2005 |2005|||||||||| QTLs In The journal of child psychology and psychiatry Oxford : Wiley-Blackwell, 1960 46(2005), 10, Seite 0 Online-Ressource (DE-627)NLEJ243927568 (DE-600)1470297-6 1469-7610 nnns volume:46 year:2005 number:10 pages:0 http://dx.doi.org/10.1111/j.1469-7610.2005.01524.x text/html Verlag Deutschlandweit zugänglich Volltext GBV_USEFLAG_U ZDB-1-DJB GBV_NL_ARTICLE AR 46 2005 10 0 |
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10.1111/j.1469-7610.2005.01524.x doi (DE-627)NLEJ243309317 DE-627 ger DE-627 rakwb Plomin, Robert verfasserin aut Finding genes in child psychology and psychiatry: When are we going to be there? Oxford, UK Blackwell Publishing Ltd 2005 Online-Ressource nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Background: The seven papers in this special section chart where we are in the quest for quantitative trait loci (QTLs) in key areas of child psychology and psychiatry such as reading and hyperactivity. But we are not there yet.Methods: This commentary considers some new developments that are likely to accelerate the journey towards the identification of QTLs.Results: The single most important factor is the need for very large samples to attain adequate power to detect and replicate QTLs of very small effect size. Another important development is the microarray, which makes it possible to genotype hundreds of thousands of SNPs simultaneously. Using microarrays in association studies allows SNPs across the whole genome to be genotyped. Microarrays will boost power even more when they contain all functional polymorphisms in the genome, including functional non-coding DNA.Conclusions: Once replicable QTLs are identified in areas such as reading and hyperactivity, the real journey will begin. Future studies will use sets of QTLs as genetic risk indicators in top-down behavioural genomic research, leading to gene-based diagnoses, gene-based treatments tailored to the individual, and early warning systems and interventions. These discoveries will eventually help to prevent or at least ameliorate childhood disorders before they cast their long shadow over development. 2005 Blackwell Publishing Journal Backfiles 1879-2005 |2005|||||||||| QTLs In The journal of child psychology and psychiatry Oxford : Wiley-Blackwell, 1960 46(2005), 10, Seite 0 Online-Ressource (DE-627)NLEJ243927568 (DE-600)1470297-6 1469-7610 nnns volume:46 year:2005 number:10 pages:0 http://dx.doi.org/10.1111/j.1469-7610.2005.01524.x text/html Verlag Deutschlandweit zugänglich Volltext GBV_USEFLAG_U ZDB-1-DJB GBV_NL_ARTICLE AR 46 2005 10 0 |
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Background: The seven papers in this special section chart where we are in the quest for quantitative trait loci (QTLs) in key areas of child psychology and psychiatry such as reading and hyperactivity. But we are not there yet.Methods: This commentary considers some new developments that are likely to accelerate the journey towards the identification of QTLs.Results: The single most important factor is the need for very large samples to attain adequate power to detect and replicate QTLs of very small effect size. Another important development is the microarray, which makes it possible to genotype hundreds of thousands of SNPs simultaneously. Using microarrays in association studies allows SNPs across the whole genome to be genotyped. Microarrays will boost power even more when they contain all functional polymorphisms in the genome, including functional non-coding DNA.Conclusions: Once replicable QTLs are identified in areas such as reading and hyperactivity, the real journey will begin. Future studies will use sets of QTLs as genetic risk indicators in top-down behavioural genomic research, leading to gene-based diagnoses, gene-based treatments tailored to the individual, and early warning systems and interventions. These discoveries will eventually help to prevent or at least ameliorate childhood disorders before they cast their long shadow over development. |
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Background: The seven papers in this special section chart where we are in the quest for quantitative trait loci (QTLs) in key areas of child psychology and psychiatry such as reading and hyperactivity. But we are not there yet.Methods: This commentary considers some new developments that are likely to accelerate the journey towards the identification of QTLs.Results: The single most important factor is the need for very large samples to attain adequate power to detect and replicate QTLs of very small effect size. Another important development is the microarray, which makes it possible to genotype hundreds of thousands of SNPs simultaneously. Using microarrays in association studies allows SNPs across the whole genome to be genotyped. Microarrays will boost power even more when they contain all functional polymorphisms in the genome, including functional non-coding DNA.Conclusions: Once replicable QTLs are identified in areas such as reading and hyperactivity, the real journey will begin. Future studies will use sets of QTLs as genetic risk indicators in top-down behavioural genomic research, leading to gene-based diagnoses, gene-based treatments tailored to the individual, and early warning systems and interventions. These discoveries will eventually help to prevent or at least ameliorate childhood disorders before they cast their long shadow over development. |
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Background: The seven papers in this special section chart where we are in the quest for quantitative trait loci (QTLs) in key areas of child psychology and psychiatry such as reading and hyperactivity. But we are not there yet.Methods: This commentary considers some new developments that are likely to accelerate the journey towards the identification of QTLs.Results: The single most important factor is the need for very large samples to attain adequate power to detect and replicate QTLs of very small effect size. Another important development is the microarray, which makes it possible to genotype hundreds of thousands of SNPs simultaneously. Using microarrays in association studies allows SNPs across the whole genome to be genotyped. Microarrays will boost power even more when they contain all functional polymorphisms in the genome, including functional non-coding DNA.Conclusions: Once replicable QTLs are identified in areas such as reading and hyperactivity, the real journey will begin. Future studies will use sets of QTLs as genetic risk indicators in top-down behavioural genomic research, leading to gene-based diagnoses, gene-based treatments tailored to the individual, and early warning systems and interventions. These discoveries will eventually help to prevent or at least ameliorate childhood disorders before they cast their long shadow over development. |
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<?xml version="1.0" encoding="UTF-8"?><collection xmlns="http://www.loc.gov/MARC21/slim"><record><leader>01000caa a22002652 4500</leader><controlfield tag="001">NLEJ243309317</controlfield><controlfield tag="003">DE-627</controlfield><controlfield tag="005">20210707175345.0</controlfield><controlfield tag="007">cr uuu---uuuuu</controlfield><controlfield tag="008">120427s2005 xx |||||o 00| ||und c</controlfield><datafield tag="024" ind1="7" ind2=" "><subfield code="a">10.1111/j.1469-7610.2005.01524.x</subfield><subfield code="2">doi</subfield></datafield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(DE-627)NLEJ243309317</subfield></datafield><datafield tag="040" ind1=" " ind2=" "><subfield code="a">DE-627</subfield><subfield code="b">ger</subfield><subfield code="c">DE-627</subfield><subfield code="e">rakwb</subfield></datafield><datafield tag="100" ind1="1" ind2=" "><subfield code="a">Plomin, Robert</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="245" ind1="1" ind2="0"><subfield code="a">Finding genes in child psychology and psychiatry: When are we going to be there?</subfield></datafield><datafield tag="264" ind1=" " ind2="1"><subfield code="a">Oxford, UK</subfield><subfield code="b">Blackwell Publishing Ltd</subfield><subfield code="c">2005</subfield></datafield><datafield tag="300" ind1=" " ind2=" "><subfield code="a">Online-Ressource</subfield></datafield><datafield tag="336" ind1=" " ind2=" "><subfield code="a">nicht spezifiziert</subfield><subfield code="b">zzz</subfield><subfield code="2">rdacontent</subfield></datafield><datafield tag="337" ind1=" " ind2=" "><subfield code="a">nicht spezifiziert</subfield><subfield code="b">z</subfield><subfield code="2">rdamedia</subfield></datafield><datafield tag="338" ind1=" " ind2=" "><subfield code="a">nicht spezifiziert</subfield><subfield code="b">zu</subfield><subfield code="2">rdacarrier</subfield></datafield><datafield tag="520" ind1=" " ind2=" "><subfield code="a">Background: The seven papers in this special section chart where we are in the quest for quantitative trait loci (QTLs) in key areas of child psychology and psychiatry such as reading and hyperactivity. But we are not there yet.Methods: This commentary considers some new developments that are likely to accelerate the journey towards the identification of QTLs.Results: The single most important factor is the need for very large samples to attain adequate power to detect and replicate QTLs of very small effect size. Another important development is the microarray, which makes it possible to genotype hundreds of thousands of SNPs simultaneously. Using microarrays in association studies allows SNPs across the whole genome to be genotyped. Microarrays will boost power even more when they contain all functional polymorphisms in the genome, including functional non-coding DNA.Conclusions: Once replicable QTLs are identified in areas such as reading and hyperactivity, the real journey will begin. Future studies will use sets of QTLs as genetic risk indicators in top-down behavioural genomic research, leading to gene-based diagnoses, gene-based treatments tailored to the individual, and early warning systems and interventions. These discoveries will eventually help to prevent or at least ameliorate childhood disorders before they cast their long shadow over development.</subfield></datafield><datafield tag="533" ind1=" " ind2=" "><subfield code="d">2005</subfield><subfield code="f">Blackwell Publishing Journal Backfiles 1879-2005</subfield><subfield code="7">|2005||||||||||</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">QTLs</subfield></datafield><datafield tag="773" ind1="0" ind2="8"><subfield code="i">In</subfield><subfield code="t">The journal of child psychology and psychiatry</subfield><subfield code="d">Oxford : Wiley-Blackwell, 1960</subfield><subfield code="g">46(2005), 10, Seite 0</subfield><subfield code="h">Online-Ressource</subfield><subfield code="w">(DE-627)NLEJ243927568</subfield><subfield code="w">(DE-600)1470297-6</subfield><subfield code="x">1469-7610</subfield><subfield code="7">nnns</subfield></datafield><datafield tag="773" ind1="1" ind2="8"><subfield code="g">volume:46</subfield><subfield code="g">year:2005</subfield><subfield code="g">number:10</subfield><subfield code="g">pages:0</subfield></datafield><datafield tag="856" ind1="4" ind2="0"><subfield code="u">http://dx.doi.org/10.1111/j.1469-7610.2005.01524.x</subfield><subfield code="q">text/html</subfield><subfield code="x">Verlag</subfield><subfield code="z">Deutschlandweit zugänglich</subfield><subfield code="3">Volltext</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_USEFLAG_U</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">ZDB-1-DJB</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_NL_ARTICLE</subfield></datafield><datafield tag="951" ind1=" " ind2=" "><subfield code="a">AR</subfield></datafield><datafield tag="952" ind1=" " ind2=" "><subfield code="d">46</subfield><subfield code="j">2005</subfield><subfield code="e">10</subfield><subfield code="h">0</subfield></datafield></record></collection>
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