Imbalance between soluble tumour necrosis factor receptors type 1 and 2 in chronic periodontitis
Background: Soluble types of tumour necrosis factor (TNF) receptors type 1 and 2 modulate the TNF-α-mediated inflammatory responses in chronic periodontitis (CP).Objectives: This study investigated the levels of TNF-α, soluble TNF receptor type 1 and 2 in gingival crevicular fluid (GCF) and serum of...
Ausführliche Beschreibung
Gespeichert in:
| Autor*in: |
Ikezawa, Ikuyo [verfasserIn] Tai, Hideaki [verfasserIn] Shimada, Yasuko [verfasserIn] |
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| Format: |
E-Artikel |
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| Erschienen: |
Oxford, UK: Munksgaard International Publishers ; 2005 |
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| Schlagwörter: |
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| Umfang: |
Online-Ressource |
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| Reproduktion: |
2005 ; Blackwell Publishing Journal Backfiles 1879-2005 |
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| Übergeordnetes Werk: |
In: Journal of clinical periodontology - Oxford [u.a.] : Wiley-Blackwell, 1974, 32(2005), 10, Seite 0 |
| Übergeordnetes Werk: |
volume:32 ; year:2005 ; number:10 ; pages:0 |
| Links: |
|---|
| DOI / URN: |
10.1111/j.1600-051X.2005.00832.x |
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| Katalog-ID: |
NLEJ243321260 |
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| 245 | 1 | 0 | |a Imbalance between soluble tumour necrosis factor receptors type 1 and 2 in chronic periodontitis |
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| 520 | |a Background: Soluble types of tumour necrosis factor (TNF) receptors type 1 and 2 modulate the TNF-α-mediated inflammatory responses in chronic periodontitis (CP).Objectives: This study investigated the levels of TNF-α, soluble TNF receptor type 1 and 2 in gingival crevicular fluid (GCF) and serum of healthy subjects and CP patients.Materials and Methods: Thirty-eight sera and 73 GCF samples were collected from 16 healthy subjects and 22 CP patients. GCF was collected from probing pocket depth (PPD)<inlineGraphic alt="leqslant R: less-than-or-eq, slant" extraInfo="nonStandardEntity" href="urn:x-wiley:03036979:JCPE832:les" location="les.gif"/>3 mm sites of healthy subjects, PPD<inlineGraphic alt="leqslant R: less-than-or-eq, slant" extraInfo="nonStandardEntity" href="urn:x-wiley:03036979:JCPE832:les" location="les.gif"/>3, 4–6 and <inlineGraphic alt="geqslant R: gt-or-equal, slanted" extraInfo="nonStandardEntity" href="urn:x-wiley:03036979:JCPE832:ges" location="ges.gif"/>7 mm sites of CP patients. The levels of TNF-α, soluble TNF receptor type 1 and 2 in the serum and GCF were quantified by enzyme-linked immunosorbant assay.Results: The total amounts of TNF-α, soluble TNF receptor type 1 and 2 in GCF significantly elevated with increasing PPD in both site-based (p<0.05) and subject-based (p<0.05) analyses. However, their levels progressively diverged as the pocket depths increased, with the soluble TNF receptor type 2 level being comparatively lower than type 1. On the other hand, soluble TNF receptor type 2/type 1 ratios in GCF decreased as the severity of periodontitis increased (p<0.0001).Conclusion: The imbalance between soluble TNF receptor type 1 and 2 levels in GCF could be related to CP severity. | ||
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| 700 | 1 | |a Tai, Hideaki |e verfasserin |4 aut | |
| 700 | 1 | |a Shimada, Yasuko |e verfasserin |4 aut | |
| 700 | 1 | |a Komatsu, Yasutaka |4 oth | |
| 700 | 1 | |a Galicia, Johnah C. |4 oth | |
| 700 | 1 | |a Yoshie, Hiromasa |4 oth | |
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10.1111/j.1600-051X.2005.00832.x doi (DE-627)NLEJ243321260 DE-627 ger DE-627 rakwb Ikezawa, Ikuyo verfasserin aut Imbalance between soluble tumour necrosis factor receptors type 1 and 2 in chronic periodontitis Oxford, UK Munksgaard International Publishers 2005 Online-Ressource nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Background: Soluble types of tumour necrosis factor (TNF) receptors type 1 and 2 modulate the TNF-α-mediated inflammatory responses in chronic periodontitis (CP).Objectives: This study investigated the levels of TNF-α, soluble TNF receptor type 1 and 2 in gingival crevicular fluid (GCF) and serum of healthy subjects and CP patients.Materials and Methods: Thirty-eight sera and 73 GCF samples were collected from 16 healthy subjects and 22 CP patients. GCF was collected from probing pocket depth (PPD)<inlineGraphic alt="leqslant R: less-than-or-eq, slant" extraInfo="nonStandardEntity" href="urn:x-wiley:03036979:JCPE832:les" location="les.gif"/>3 mm sites of healthy subjects, PPD<inlineGraphic alt="leqslant R: less-than-or-eq, slant" extraInfo="nonStandardEntity" href="urn:x-wiley:03036979:JCPE832:les" location="les.gif"/>3, 4–6 and <inlineGraphic alt="geqslant R: gt-or-equal, slanted" extraInfo="nonStandardEntity" href="urn:x-wiley:03036979:JCPE832:ges" location="ges.gif"/>7 mm sites of CP patients. The levels of TNF-α, soluble TNF receptor type 1 and 2 in the serum and GCF were quantified by enzyme-linked immunosorbant assay.Results: The total amounts of TNF-α, soluble TNF receptor type 1 and 2 in GCF significantly elevated with increasing PPD in both site-based (p<0.05) and subject-based (p<0.05) analyses. However, their levels progressively diverged as the pocket depths increased, with the soluble TNF receptor type 2 level being comparatively lower than type 1. On the other hand, soluble TNF receptor type 2/type 1 ratios in GCF decreased as the severity of periodontitis increased (p<0.0001).Conclusion: The imbalance between soluble TNF receptor type 1 and 2 levels in GCF could be related to CP severity. 2005 Blackwell Publishing Journal Backfiles 1879-2005 |2005|||||||||| chronic periodontitis Tai, Hideaki verfasserin aut Shimada, Yasuko verfasserin aut Komatsu, Yasutaka oth Galicia, Johnah C. oth Yoshie, Hiromasa oth In Journal of clinical periodontology Oxford [u.a.] : Wiley-Blackwell, 1974 32(2005), 10, Seite 0 Online-Ressource (DE-627)NLEJ243927142 (DE-600)2026349-1 1600-051X nnns volume:32 year:2005 number:10 pages:0 http://dx.doi.org/10.1111/j.1600-051X.2005.00832.x text/html Verlag Deutschlandweit zugänglich Volltext GBV_USEFLAG_U ZDB-1-DJB GBV_NL_ARTICLE AR 32 2005 10 0 |
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10.1111/j.1600-051X.2005.00832.x doi (DE-627)NLEJ243321260 DE-627 ger DE-627 rakwb Ikezawa, Ikuyo verfasserin aut Imbalance between soluble tumour necrosis factor receptors type 1 and 2 in chronic periodontitis Oxford, UK Munksgaard International Publishers 2005 Online-Ressource nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Background: Soluble types of tumour necrosis factor (TNF) receptors type 1 and 2 modulate the TNF-α-mediated inflammatory responses in chronic periodontitis (CP).Objectives: This study investigated the levels of TNF-α, soluble TNF receptor type 1 and 2 in gingival crevicular fluid (GCF) and serum of healthy subjects and CP patients.Materials and Methods: Thirty-eight sera and 73 GCF samples were collected from 16 healthy subjects and 22 CP patients. GCF was collected from probing pocket depth (PPD)<inlineGraphic alt="leqslant R: less-than-or-eq, slant" extraInfo="nonStandardEntity" href="urn:x-wiley:03036979:JCPE832:les" location="les.gif"/>3 mm sites of healthy subjects, PPD<inlineGraphic alt="leqslant R: less-than-or-eq, slant" extraInfo="nonStandardEntity" href="urn:x-wiley:03036979:JCPE832:les" location="les.gif"/>3, 4–6 and <inlineGraphic alt="geqslant R: gt-or-equal, slanted" extraInfo="nonStandardEntity" href="urn:x-wiley:03036979:JCPE832:ges" location="ges.gif"/>7 mm sites of CP patients. The levels of TNF-α, soluble TNF receptor type 1 and 2 in the serum and GCF were quantified by enzyme-linked immunosorbant assay.Results: The total amounts of TNF-α, soluble TNF receptor type 1 and 2 in GCF significantly elevated with increasing PPD in both site-based (p<0.05) and subject-based (p<0.05) analyses. However, their levels progressively diverged as the pocket depths increased, with the soluble TNF receptor type 2 level being comparatively lower than type 1. On the other hand, soluble TNF receptor type 2/type 1 ratios in GCF decreased as the severity of periodontitis increased (p<0.0001).Conclusion: The imbalance between soluble TNF receptor type 1 and 2 levels in GCF could be related to CP severity. 2005 Blackwell Publishing Journal Backfiles 1879-2005 |2005|||||||||| chronic periodontitis Tai, Hideaki verfasserin aut Shimada, Yasuko verfasserin aut Komatsu, Yasutaka oth Galicia, Johnah C. oth Yoshie, Hiromasa oth In Journal of clinical periodontology Oxford [u.a.] : Wiley-Blackwell, 1974 32(2005), 10, Seite 0 Online-Ressource (DE-627)NLEJ243927142 (DE-600)2026349-1 1600-051X nnns volume:32 year:2005 number:10 pages:0 http://dx.doi.org/10.1111/j.1600-051X.2005.00832.x text/html Verlag Deutschlandweit zugänglich Volltext GBV_USEFLAG_U ZDB-1-DJB GBV_NL_ARTICLE AR 32 2005 10 0 |
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10.1111/j.1600-051X.2005.00832.x doi (DE-627)NLEJ243321260 DE-627 ger DE-627 rakwb Ikezawa, Ikuyo verfasserin aut Imbalance between soluble tumour necrosis factor receptors type 1 and 2 in chronic periodontitis Oxford, UK Munksgaard International Publishers 2005 Online-Ressource nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Background: Soluble types of tumour necrosis factor (TNF) receptors type 1 and 2 modulate the TNF-α-mediated inflammatory responses in chronic periodontitis (CP).Objectives: This study investigated the levels of TNF-α, soluble TNF receptor type 1 and 2 in gingival crevicular fluid (GCF) and serum of healthy subjects and CP patients.Materials and Methods: Thirty-eight sera and 73 GCF samples were collected from 16 healthy subjects and 22 CP patients. GCF was collected from probing pocket depth (PPD)<inlineGraphic alt="leqslant R: less-than-or-eq, slant" extraInfo="nonStandardEntity" href="urn:x-wiley:03036979:JCPE832:les" location="les.gif"/>3 mm sites of healthy subjects, PPD<inlineGraphic alt="leqslant R: less-than-or-eq, slant" extraInfo="nonStandardEntity" href="urn:x-wiley:03036979:JCPE832:les" location="les.gif"/>3, 4–6 and <inlineGraphic alt="geqslant R: gt-or-equal, slanted" extraInfo="nonStandardEntity" href="urn:x-wiley:03036979:JCPE832:ges" location="ges.gif"/>7 mm sites of CP patients. The levels of TNF-α, soluble TNF receptor type 1 and 2 in the serum and GCF were quantified by enzyme-linked immunosorbant assay.Results: The total amounts of TNF-α, soluble TNF receptor type 1 and 2 in GCF significantly elevated with increasing PPD in both site-based (p<0.05) and subject-based (p<0.05) analyses. However, their levels progressively diverged as the pocket depths increased, with the soluble TNF receptor type 2 level being comparatively lower than type 1. On the other hand, soluble TNF receptor type 2/type 1 ratios in GCF decreased as the severity of periodontitis increased (p<0.0001).Conclusion: The imbalance between soluble TNF receptor type 1 and 2 levels in GCF could be related to CP severity. 2005 Blackwell Publishing Journal Backfiles 1879-2005 |2005|||||||||| chronic periodontitis Tai, Hideaki verfasserin aut Shimada, Yasuko verfasserin aut Komatsu, Yasutaka oth Galicia, Johnah C. oth Yoshie, Hiromasa oth In Journal of clinical periodontology Oxford [u.a.] : Wiley-Blackwell, 1974 32(2005), 10, Seite 0 Online-Ressource (DE-627)NLEJ243927142 (DE-600)2026349-1 1600-051X nnns volume:32 year:2005 number:10 pages:0 http://dx.doi.org/10.1111/j.1600-051X.2005.00832.x text/html Verlag Deutschlandweit zugänglich Volltext GBV_USEFLAG_U ZDB-1-DJB GBV_NL_ARTICLE AR 32 2005 10 0 |
| allfieldsGer |
10.1111/j.1600-051X.2005.00832.x doi (DE-627)NLEJ243321260 DE-627 ger DE-627 rakwb Ikezawa, Ikuyo verfasserin aut Imbalance between soluble tumour necrosis factor receptors type 1 and 2 in chronic periodontitis Oxford, UK Munksgaard International Publishers 2005 Online-Ressource nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Background: Soluble types of tumour necrosis factor (TNF) receptors type 1 and 2 modulate the TNF-α-mediated inflammatory responses in chronic periodontitis (CP).Objectives: This study investigated the levels of TNF-α, soluble TNF receptor type 1 and 2 in gingival crevicular fluid (GCF) and serum of healthy subjects and CP patients.Materials and Methods: Thirty-eight sera and 73 GCF samples were collected from 16 healthy subjects and 22 CP patients. GCF was collected from probing pocket depth (PPD)<inlineGraphic alt="leqslant R: less-than-or-eq, slant" extraInfo="nonStandardEntity" href="urn:x-wiley:03036979:JCPE832:les" location="les.gif"/>3 mm sites of healthy subjects, PPD<inlineGraphic alt="leqslant R: less-than-or-eq, slant" extraInfo="nonStandardEntity" href="urn:x-wiley:03036979:JCPE832:les" location="les.gif"/>3, 4–6 and <inlineGraphic alt="geqslant R: gt-or-equal, slanted" extraInfo="nonStandardEntity" href="urn:x-wiley:03036979:JCPE832:ges" location="ges.gif"/>7 mm sites of CP patients. The levels of TNF-α, soluble TNF receptor type 1 and 2 in the serum and GCF were quantified by enzyme-linked immunosorbant assay.Results: The total amounts of TNF-α, soluble TNF receptor type 1 and 2 in GCF significantly elevated with increasing PPD in both site-based (p<0.05) and subject-based (p<0.05) analyses. However, their levels progressively diverged as the pocket depths increased, with the soluble TNF receptor type 2 level being comparatively lower than type 1. On the other hand, soluble TNF receptor type 2/type 1 ratios in GCF decreased as the severity of periodontitis increased (p<0.0001).Conclusion: The imbalance between soluble TNF receptor type 1 and 2 levels in GCF could be related to CP severity. 2005 Blackwell Publishing Journal Backfiles 1879-2005 |2005|||||||||| chronic periodontitis Tai, Hideaki verfasserin aut Shimada, Yasuko verfasserin aut Komatsu, Yasutaka oth Galicia, Johnah C. oth Yoshie, Hiromasa oth In Journal of clinical periodontology Oxford [u.a.] : Wiley-Blackwell, 1974 32(2005), 10, Seite 0 Online-Ressource (DE-627)NLEJ243927142 (DE-600)2026349-1 1600-051X nnns volume:32 year:2005 number:10 pages:0 http://dx.doi.org/10.1111/j.1600-051X.2005.00832.x text/html Verlag Deutschlandweit zugänglich Volltext GBV_USEFLAG_U ZDB-1-DJB GBV_NL_ARTICLE AR 32 2005 10 0 |
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10.1111/j.1600-051X.2005.00832.x doi (DE-627)NLEJ243321260 DE-627 ger DE-627 rakwb Ikezawa, Ikuyo verfasserin aut Imbalance between soluble tumour necrosis factor receptors type 1 and 2 in chronic periodontitis Oxford, UK Munksgaard International Publishers 2005 Online-Ressource nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Background: Soluble types of tumour necrosis factor (TNF) receptors type 1 and 2 modulate the TNF-α-mediated inflammatory responses in chronic periodontitis (CP).Objectives: This study investigated the levels of TNF-α, soluble TNF receptor type 1 and 2 in gingival crevicular fluid (GCF) and serum of healthy subjects and CP patients.Materials and Methods: Thirty-eight sera and 73 GCF samples were collected from 16 healthy subjects and 22 CP patients. GCF was collected from probing pocket depth (PPD)<inlineGraphic alt="leqslant R: less-than-or-eq, slant" extraInfo="nonStandardEntity" href="urn:x-wiley:03036979:JCPE832:les" location="les.gif"/>3 mm sites of healthy subjects, PPD<inlineGraphic alt="leqslant R: less-than-or-eq, slant" extraInfo="nonStandardEntity" href="urn:x-wiley:03036979:JCPE832:les" location="les.gif"/>3, 4–6 and <inlineGraphic alt="geqslant R: gt-or-equal, slanted" extraInfo="nonStandardEntity" href="urn:x-wiley:03036979:JCPE832:ges" location="ges.gif"/>7 mm sites of CP patients. The levels of TNF-α, soluble TNF receptor type 1 and 2 in the serum and GCF were quantified by enzyme-linked immunosorbant assay.Results: The total amounts of TNF-α, soluble TNF receptor type 1 and 2 in GCF significantly elevated with increasing PPD in both site-based (p<0.05) and subject-based (p<0.05) analyses. However, their levels progressively diverged as the pocket depths increased, with the soluble TNF receptor type 2 level being comparatively lower than type 1. On the other hand, soluble TNF receptor type 2/type 1 ratios in GCF decreased as the severity of periodontitis increased (p<0.0001).Conclusion: The imbalance between soluble TNF receptor type 1 and 2 levels in GCF could be related to CP severity. 2005 Blackwell Publishing Journal Backfiles 1879-2005 |2005|||||||||| chronic periodontitis Tai, Hideaki verfasserin aut Shimada, Yasuko verfasserin aut Komatsu, Yasutaka oth Galicia, Johnah C. oth Yoshie, Hiromasa oth In Journal of clinical periodontology Oxford [u.a.] : Wiley-Blackwell, 1974 32(2005), 10, Seite 0 Online-Ressource (DE-627)NLEJ243927142 (DE-600)2026349-1 1600-051X nnns volume:32 year:2005 number:10 pages:0 http://dx.doi.org/10.1111/j.1600-051X.2005.00832.x text/html Verlag Deutschlandweit zugänglich Volltext GBV_USEFLAG_U ZDB-1-DJB GBV_NL_ARTICLE AR 32 2005 10 0 |
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GCF was collected from probing pocket depth (PPD)<inlineGraphic alt="leqslant R: less-than-or-eq, slant" extraInfo="nonStandardEntity" href="urn:x-wiley:03036979:JCPE832:les" location="les.gif"/>3 mm sites of healthy subjects, PPD<inlineGraphic alt="leqslant R: less-than-or-eq, slant" extraInfo="nonStandardEntity" href="urn:x-wiley:03036979:JCPE832:les" location="les.gif"/>3, 4–6 and <inlineGraphic alt="geqslant R: gt-or-equal, slanted" extraInfo="nonStandardEntity" href="urn:x-wiley:03036979:JCPE832:ges" location="ges.gif"/>7 mm sites of CP patients. The levels of TNF-α, soluble TNF receptor type 1 and 2 in the serum and GCF were quantified by enzyme-linked immunosorbant assay.Results: The total amounts of TNF-α, soluble TNF receptor type 1 and 2 in GCF significantly elevated with increasing PPD in both site-based (p<0.05) and subject-based (p<0.05) analyses. However, their levels progressively diverged as the pocket depths increased, with the soluble TNF receptor type 2 level being comparatively lower than type 1. 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Imbalance between soluble tumour necrosis factor receptors type 1 and 2 in chronic periodontitis chronic periodontitis |
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Imbalance between soluble tumour necrosis factor receptors type 1 and 2 in chronic periodontitis |
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Ikezawa, Ikuyo Tai, Hideaki Shimada, Yasuko |
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Ikezawa, Ikuyo |
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imbalance between soluble tumour necrosis factor receptors type 1 and 2 in chronic periodontitis |
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Imbalance between soluble tumour necrosis factor receptors type 1 and 2 in chronic periodontitis |
| abstract |
Background: Soluble types of tumour necrosis factor (TNF) receptors type 1 and 2 modulate the TNF-α-mediated inflammatory responses in chronic periodontitis (CP).Objectives: This study investigated the levels of TNF-α, soluble TNF receptor type 1 and 2 in gingival crevicular fluid (GCF) and serum of healthy subjects and CP patients.Materials and Methods: Thirty-eight sera and 73 GCF samples were collected from 16 healthy subjects and 22 CP patients. GCF was collected from probing pocket depth (PPD)<inlineGraphic alt="leqslant R: less-than-or-eq, slant" extraInfo="nonStandardEntity" href="urn:x-wiley:03036979:JCPE832:les" location="les.gif"/>3 mm sites of healthy subjects, PPD<inlineGraphic alt="leqslant R: less-than-or-eq, slant" extraInfo="nonStandardEntity" href="urn:x-wiley:03036979:JCPE832:les" location="les.gif"/>3, 4–6 and <inlineGraphic alt="geqslant R: gt-or-equal, slanted" extraInfo="nonStandardEntity" href="urn:x-wiley:03036979:JCPE832:ges" location="ges.gif"/>7 mm sites of CP patients. The levels of TNF-α, soluble TNF receptor type 1 and 2 in the serum and GCF were quantified by enzyme-linked immunosorbant assay.Results: The total amounts of TNF-α, soluble TNF receptor type 1 and 2 in GCF significantly elevated with increasing PPD in both site-based (p<0.05) and subject-based (p<0.05) analyses. However, their levels progressively diverged as the pocket depths increased, with the soluble TNF receptor type 2 level being comparatively lower than type 1. On the other hand, soluble TNF receptor type 2/type 1 ratios in GCF decreased as the severity of periodontitis increased (p<0.0001).Conclusion: The imbalance between soluble TNF receptor type 1 and 2 levels in GCF could be related to CP severity. |
| abstractGer |
Background: Soluble types of tumour necrosis factor (TNF) receptors type 1 and 2 modulate the TNF-α-mediated inflammatory responses in chronic periodontitis (CP).Objectives: This study investigated the levels of TNF-α, soluble TNF receptor type 1 and 2 in gingival crevicular fluid (GCF) and serum of healthy subjects and CP patients.Materials and Methods: Thirty-eight sera and 73 GCF samples were collected from 16 healthy subjects and 22 CP patients. GCF was collected from probing pocket depth (PPD)<inlineGraphic alt="leqslant R: less-than-or-eq, slant" extraInfo="nonStandardEntity" href="urn:x-wiley:03036979:JCPE832:les" location="les.gif"/>3 mm sites of healthy subjects, PPD<inlineGraphic alt="leqslant R: less-than-or-eq, slant" extraInfo="nonStandardEntity" href="urn:x-wiley:03036979:JCPE832:les" location="les.gif"/>3, 4–6 and <inlineGraphic alt="geqslant R: gt-or-equal, slanted" extraInfo="nonStandardEntity" href="urn:x-wiley:03036979:JCPE832:ges" location="ges.gif"/>7 mm sites of CP patients. The levels of TNF-α, soluble TNF receptor type 1 and 2 in the serum and GCF were quantified by enzyme-linked immunosorbant assay.Results: The total amounts of TNF-α, soluble TNF receptor type 1 and 2 in GCF significantly elevated with increasing PPD in both site-based (p<0.05) and subject-based (p<0.05) analyses. However, their levels progressively diverged as the pocket depths increased, with the soluble TNF receptor type 2 level being comparatively lower than type 1. On the other hand, soluble TNF receptor type 2/type 1 ratios in GCF decreased as the severity of periodontitis increased (p<0.0001).Conclusion: The imbalance between soluble TNF receptor type 1 and 2 levels in GCF could be related to CP severity. |
| abstract_unstemmed |
Background: Soluble types of tumour necrosis factor (TNF) receptors type 1 and 2 modulate the TNF-α-mediated inflammatory responses in chronic periodontitis (CP).Objectives: This study investigated the levels of TNF-α, soluble TNF receptor type 1 and 2 in gingival crevicular fluid (GCF) and serum of healthy subjects and CP patients.Materials and Methods: Thirty-eight sera and 73 GCF samples were collected from 16 healthy subjects and 22 CP patients. GCF was collected from probing pocket depth (PPD)<inlineGraphic alt="leqslant R: less-than-or-eq, slant" extraInfo="nonStandardEntity" href="urn:x-wiley:03036979:JCPE832:les" location="les.gif"/>3 mm sites of healthy subjects, PPD<inlineGraphic alt="leqslant R: less-than-or-eq, slant" extraInfo="nonStandardEntity" href="urn:x-wiley:03036979:JCPE832:les" location="les.gif"/>3, 4–6 and <inlineGraphic alt="geqslant R: gt-or-equal, slanted" extraInfo="nonStandardEntity" href="urn:x-wiley:03036979:JCPE832:ges" location="ges.gif"/>7 mm sites of CP patients. The levels of TNF-α, soluble TNF receptor type 1 and 2 in the serum and GCF were quantified by enzyme-linked immunosorbant assay.Results: The total amounts of TNF-α, soluble TNF receptor type 1 and 2 in GCF significantly elevated with increasing PPD in both site-based (p<0.05) and subject-based (p<0.05) analyses. However, their levels progressively diverged as the pocket depths increased, with the soluble TNF receptor type 2 level being comparatively lower than type 1. On the other hand, soluble TNF receptor type 2/type 1 ratios in GCF decreased as the severity of periodontitis increased (p<0.0001).Conclusion: The imbalance between soluble TNF receptor type 1 and 2 levels in GCF could be related to CP severity. |
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Imbalance between soluble tumour necrosis factor receptors type 1 and 2 in chronic periodontitis |
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Tai, Hideaki Shimada, Yasuko Komatsu, Yasutaka Galicia, Johnah C. Yoshie, Hiromasa |
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