Effect of triclosan on interferon-γ production and major histocompatibility complex class II expression in human gingival fibroblasts
Background, aims: The effect of triclosan (2,4,4′-trichloro-2′-hydroxyl-diphenyl ether) on the production of interferon-γ (IFN-γ) and the expression of major histocompatibility complex (MHC) class II antigen was studied in human gingival fibroblasts isolated from 4 individuals.<section xml:id=&qu...
Ausführliche Beschreibung
Gespeichert in:
| Autor*in: |
Mustafa, Manal [verfasserIn] Bakhiet, Moiz [verfasserIn] Wondimu, Biniyam [verfasserIn] |
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| Format: |
E-Artikel |
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| Erschienen: |
Copenhagen: Munksgaard International Publishers ; 2000 |
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| Umfang: |
Online-Ressource |
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| Reproduktion: |
2001 ; Blackwell Publishing Journal Backfiles 1879-2005 |
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| Übergeordnetes Werk: |
In: Journal of clinical periodontology - Oxford [u.a.] : Wiley-Blackwell, 1974, 27(2000), 10, Seite 0 |
| Übergeordnetes Werk: |
volume:27 ; year:2000 ; number:10 ; pages:0 |
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| DOI / URN: |
10.1034/j.1600-051x.2000.027010733.x |
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NLEJ243329636 |
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| 520 | |a Background, aims: The effect of triclosan (2,4,4′-trichloro-2′-hydroxyl-diphenyl ether) on the production of interferon-γ (IFN-γ) and the expression of major histocompatibility complex (MHC) class II antigen was studied in human gingival fibroblasts isolated from 4 individuals.<section xml:id="abs1-2"><title type="main">Methods/Results: AII cell lines demonstrated high IFN-γ production in 24-h cultures of human gingival fibroblasts stimulated by phytohemagglutinin (PHA) (5 μg/ml). Human gingival fibroblasts showed a high expression of MHC class II when stimulated with 500 and 1000 pg/ml rIFN-γ in 7-day cultures. Treatment of the cells with triclosan (0.5 μg/ml) reduced both IFN-γ production and MHC class II expression in human gingival fibroblast cultures. Similar inhibitory effects on IFN-γ production and MHC class II expression were observed when the anti-inflammatory agent dexamethazone (1 μM) was used.Conclusion: The present study further supports the view that the agent has an anti-inflammatory effect in addition to its antibacterial capacity. | ||
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10.1034/j.1600-051x.2000.027010733.x doi (DE-627)NLEJ243329636 DE-627 ger DE-627 rakwb Mustafa, Manal verfasserin aut Effect of triclosan on interferon-γ production and major histocompatibility complex class II expression in human gingival fibroblasts Copenhagen Munksgaard International Publishers 2000 Online-Ressource nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Background, aims: The effect of triclosan (2,4,4′-trichloro-2′-hydroxyl-diphenyl ether) on the production of interferon-γ (IFN-γ) and the expression of major histocompatibility complex (MHC) class II antigen was studied in human gingival fibroblasts isolated from 4 individuals.<section xml:id="abs1-2"><title type="main">Methods/Results: AII cell lines demonstrated high IFN-γ production in 24-h cultures of human gingival fibroblasts stimulated by phytohemagglutinin (PHA) (5 μg/ml). Human gingival fibroblasts showed a high expression of MHC class II when stimulated with 500 and 1000 pg/ml rIFN-γ in 7-day cultures. Treatment of the cells with triclosan (0.5 μg/ml) reduced both IFN-γ production and MHC class II expression in human gingival fibroblast cultures. Similar inhibitory effects on IFN-γ production and MHC class II expression were observed when the anti-inflammatory agent dexamethazone (1 μM) was used.Conclusion: The present study further supports the view that the agent has an anti-inflammatory effect in addition to its antibacterial capacity. 2001 Blackwell Publishing Journal Backfiles 1879-2005 |2001|||||||||| gingival fibroblasts Bakhiet, Moiz verfasserin aut Wondimu, Biniyam verfasserin aut Modéer, Thomas oth In Journal of clinical periodontology Oxford [u.a.] : Wiley-Blackwell, 1974 27(2000), 10, Seite 0 Online-Ressource (DE-627)NLEJ243927142 (DE-600)2026349-1 1600-051X nnns volume:27 year:2000 number:10 pages:0 http://dx.doi.org/10.1034/j.1600-051x.2000.027010733.x text/html Verlag Deutschlandweit zugänglich Volltext GBV_USEFLAG_U ZDB-1-DJB GBV_NL_ARTICLE AR 27 2000 10 0 |
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10.1034/j.1600-051x.2000.027010733.x doi (DE-627)NLEJ243329636 DE-627 ger DE-627 rakwb Mustafa, Manal verfasserin aut Effect of triclosan on interferon-γ production and major histocompatibility complex class II expression in human gingival fibroblasts Copenhagen Munksgaard International Publishers 2000 Online-Ressource nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Background, aims: The effect of triclosan (2,4,4′-trichloro-2′-hydroxyl-diphenyl ether) on the production of interferon-γ (IFN-γ) and the expression of major histocompatibility complex (MHC) class II antigen was studied in human gingival fibroblasts isolated from 4 individuals.<section xml:id="abs1-2"><title type="main">Methods/Results: AII cell lines demonstrated high IFN-γ production in 24-h cultures of human gingival fibroblasts stimulated by phytohemagglutinin (PHA) (5 μg/ml). Human gingival fibroblasts showed a high expression of MHC class II when stimulated with 500 and 1000 pg/ml rIFN-γ in 7-day cultures. Treatment of the cells with triclosan (0.5 μg/ml) reduced both IFN-γ production and MHC class II expression in human gingival fibroblast cultures. Similar inhibitory effects on IFN-γ production and MHC class II expression were observed when the anti-inflammatory agent dexamethazone (1 μM) was used.Conclusion: The present study further supports the view that the agent has an anti-inflammatory effect in addition to its antibacterial capacity. 2001 Blackwell Publishing Journal Backfiles 1879-2005 |2001|||||||||| gingival fibroblasts Bakhiet, Moiz verfasserin aut Wondimu, Biniyam verfasserin aut Modéer, Thomas oth In Journal of clinical periodontology Oxford [u.a.] : Wiley-Blackwell, 1974 27(2000), 10, Seite 0 Online-Ressource (DE-627)NLEJ243927142 (DE-600)2026349-1 1600-051X nnns volume:27 year:2000 number:10 pages:0 http://dx.doi.org/10.1034/j.1600-051x.2000.027010733.x text/html Verlag Deutschlandweit zugänglich Volltext GBV_USEFLAG_U ZDB-1-DJB GBV_NL_ARTICLE AR 27 2000 10 0 |
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10.1034/j.1600-051x.2000.027010733.x doi (DE-627)NLEJ243329636 DE-627 ger DE-627 rakwb Mustafa, Manal verfasserin aut Effect of triclosan on interferon-γ production and major histocompatibility complex class II expression in human gingival fibroblasts Copenhagen Munksgaard International Publishers 2000 Online-Ressource nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Background, aims: The effect of triclosan (2,4,4′-trichloro-2′-hydroxyl-diphenyl ether) on the production of interferon-γ (IFN-γ) and the expression of major histocompatibility complex (MHC) class II antigen was studied in human gingival fibroblasts isolated from 4 individuals.<section xml:id="abs1-2"><title type="main">Methods/Results: AII cell lines demonstrated high IFN-γ production in 24-h cultures of human gingival fibroblasts stimulated by phytohemagglutinin (PHA) (5 μg/ml). Human gingival fibroblasts showed a high expression of MHC class II when stimulated with 500 and 1000 pg/ml rIFN-γ in 7-day cultures. Treatment of the cells with triclosan (0.5 μg/ml) reduced both IFN-γ production and MHC class II expression in human gingival fibroblast cultures. Similar inhibitory effects on IFN-γ production and MHC class II expression were observed when the anti-inflammatory agent dexamethazone (1 μM) was used.Conclusion: The present study further supports the view that the agent has an anti-inflammatory effect in addition to its antibacterial capacity. 2001 Blackwell Publishing Journal Backfiles 1879-2005 |2001|||||||||| gingival fibroblasts Bakhiet, Moiz verfasserin aut Wondimu, Biniyam verfasserin aut Modéer, Thomas oth In Journal of clinical periodontology Oxford [u.a.] : Wiley-Blackwell, 1974 27(2000), 10, Seite 0 Online-Ressource (DE-627)NLEJ243927142 (DE-600)2026349-1 1600-051X nnns volume:27 year:2000 number:10 pages:0 http://dx.doi.org/10.1034/j.1600-051x.2000.027010733.x text/html Verlag Deutschlandweit zugänglich Volltext GBV_USEFLAG_U ZDB-1-DJB GBV_NL_ARTICLE AR 27 2000 10 0 |
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10.1034/j.1600-051x.2000.027010733.x doi (DE-627)NLEJ243329636 DE-627 ger DE-627 rakwb Mustafa, Manal verfasserin aut Effect of triclosan on interferon-γ production and major histocompatibility complex class II expression in human gingival fibroblasts Copenhagen Munksgaard International Publishers 2000 Online-Ressource nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Background, aims: The effect of triclosan (2,4,4′-trichloro-2′-hydroxyl-diphenyl ether) on the production of interferon-γ (IFN-γ) and the expression of major histocompatibility complex (MHC) class II antigen was studied in human gingival fibroblasts isolated from 4 individuals.<section xml:id="abs1-2"><title type="main">Methods/Results: AII cell lines demonstrated high IFN-γ production in 24-h cultures of human gingival fibroblasts stimulated by phytohemagglutinin (PHA) (5 μg/ml). Human gingival fibroblasts showed a high expression of MHC class II when stimulated with 500 and 1000 pg/ml rIFN-γ in 7-day cultures. Treatment of the cells with triclosan (0.5 μg/ml) reduced both IFN-γ production and MHC class II expression in human gingival fibroblast cultures. Similar inhibitory effects on IFN-γ production and MHC class II expression were observed when the anti-inflammatory agent dexamethazone (1 μM) was used.Conclusion: The present study further supports the view that the agent has an anti-inflammatory effect in addition to its antibacterial capacity. 2001 Blackwell Publishing Journal Backfiles 1879-2005 |2001|||||||||| gingival fibroblasts Bakhiet, Moiz verfasserin aut Wondimu, Biniyam verfasserin aut Modéer, Thomas oth In Journal of clinical periodontology Oxford [u.a.] : Wiley-Blackwell, 1974 27(2000), 10, Seite 0 Online-Ressource (DE-627)NLEJ243927142 (DE-600)2026349-1 1600-051X nnns volume:27 year:2000 number:10 pages:0 http://dx.doi.org/10.1034/j.1600-051x.2000.027010733.x text/html Verlag Deutschlandweit zugänglich Volltext GBV_USEFLAG_U ZDB-1-DJB GBV_NL_ARTICLE AR 27 2000 10 0 |
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10.1034/j.1600-051x.2000.027010733.x doi (DE-627)NLEJ243329636 DE-627 ger DE-627 rakwb Mustafa, Manal verfasserin aut Effect of triclosan on interferon-γ production and major histocompatibility complex class II expression in human gingival fibroblasts Copenhagen Munksgaard International Publishers 2000 Online-Ressource nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Background, aims: The effect of triclosan (2,4,4′-trichloro-2′-hydroxyl-diphenyl ether) on the production of interferon-γ (IFN-γ) and the expression of major histocompatibility complex (MHC) class II antigen was studied in human gingival fibroblasts isolated from 4 individuals.<section xml:id="abs1-2"><title type="main">Methods/Results: AII cell lines demonstrated high IFN-γ production in 24-h cultures of human gingival fibroblasts stimulated by phytohemagglutinin (PHA) (5 μg/ml). Human gingival fibroblasts showed a high expression of MHC class II when stimulated with 500 and 1000 pg/ml rIFN-γ in 7-day cultures. Treatment of the cells with triclosan (0.5 μg/ml) reduced both IFN-γ production and MHC class II expression in human gingival fibroblast cultures. Similar inhibitory effects on IFN-γ production and MHC class II expression were observed when the anti-inflammatory agent dexamethazone (1 μM) was used.Conclusion: The present study further supports the view that the agent has an anti-inflammatory effect in addition to its antibacterial capacity. 2001 Blackwell Publishing Journal Backfiles 1879-2005 |2001|||||||||| gingival fibroblasts Bakhiet, Moiz verfasserin aut Wondimu, Biniyam verfasserin aut Modéer, Thomas oth In Journal of clinical periodontology Oxford [u.a.] : Wiley-Blackwell, 1974 27(2000), 10, Seite 0 Online-Ressource (DE-627)NLEJ243927142 (DE-600)2026349-1 1600-051X nnns volume:27 year:2000 number:10 pages:0 http://dx.doi.org/10.1034/j.1600-051x.2000.027010733.x text/html Verlag Deutschlandweit zugänglich Volltext GBV_USEFLAG_U ZDB-1-DJB GBV_NL_ARTICLE AR 27 2000 10 0 |
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Effect of triclosan on interferon-γ production and major histocompatibility complex class II expression in human gingival fibroblasts |
| abstract |
Background, aims: The effect of triclosan (2,4,4′-trichloro-2′-hydroxyl-diphenyl ether) on the production of interferon-γ (IFN-γ) and the expression of major histocompatibility complex (MHC) class II antigen was studied in human gingival fibroblasts isolated from 4 individuals.<section xml:id="abs1-2"><title type="main">Methods/Results: AII cell lines demonstrated high IFN-γ production in 24-h cultures of human gingival fibroblasts stimulated by phytohemagglutinin (PHA) (5 μg/ml). Human gingival fibroblasts showed a high expression of MHC class II when stimulated with 500 and 1000 pg/ml rIFN-γ in 7-day cultures. Treatment of the cells with triclosan (0.5 μg/ml) reduced both IFN-γ production and MHC class II expression in human gingival fibroblast cultures. Similar inhibitory effects on IFN-γ production and MHC class II expression were observed when the anti-inflammatory agent dexamethazone (1 μM) was used.Conclusion: The present study further supports the view that the agent has an anti-inflammatory effect in addition to its antibacterial capacity. |
| abstractGer |
Background, aims: The effect of triclosan (2,4,4′-trichloro-2′-hydroxyl-diphenyl ether) on the production of interferon-γ (IFN-γ) and the expression of major histocompatibility complex (MHC) class II antigen was studied in human gingival fibroblasts isolated from 4 individuals.<section xml:id="abs1-2"><title type="main">Methods/Results: AII cell lines demonstrated high IFN-γ production in 24-h cultures of human gingival fibroblasts stimulated by phytohemagglutinin (PHA) (5 μg/ml). Human gingival fibroblasts showed a high expression of MHC class II when stimulated with 500 and 1000 pg/ml rIFN-γ in 7-day cultures. Treatment of the cells with triclosan (0.5 μg/ml) reduced both IFN-γ production and MHC class II expression in human gingival fibroblast cultures. Similar inhibitory effects on IFN-γ production and MHC class II expression were observed when the anti-inflammatory agent dexamethazone (1 μM) was used.Conclusion: The present study further supports the view that the agent has an anti-inflammatory effect in addition to its antibacterial capacity. |
| abstract_unstemmed |
Background, aims: The effect of triclosan (2,4,4′-trichloro-2′-hydroxyl-diphenyl ether) on the production of interferon-γ (IFN-γ) and the expression of major histocompatibility complex (MHC) class II antigen was studied in human gingival fibroblasts isolated from 4 individuals.<section xml:id="abs1-2"><title type="main">Methods/Results: AII cell lines demonstrated high IFN-γ production in 24-h cultures of human gingival fibroblasts stimulated by phytohemagglutinin (PHA) (5 μg/ml). Human gingival fibroblasts showed a high expression of MHC class II when stimulated with 500 and 1000 pg/ml rIFN-γ in 7-day cultures. Treatment of the cells with triclosan (0.5 μg/ml) reduced both IFN-γ production and MHC class II expression in human gingival fibroblast cultures. Similar inhibitory effects on IFN-γ production and MHC class II expression were observed when the anti-inflammatory agent dexamethazone (1 μM) was used.Conclusion: The present study further supports the view that the agent has an anti-inflammatory effect in addition to its antibacterial capacity. |
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Effect of triclosan on interferon-γ production and major histocompatibility complex class II expression in human gingival fibroblasts |
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Bakhiet, Moiz Wondimu, Biniyam Modéer, Thomas |
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