Severe and Early Alteration of Action Potential During Acute Cardiac Rejection in Rats
Alteration of Cardiac Action Potential. Introduction: Alteration of cardiac action potential and its adaptation to heart rate could contribute to cardiac dysfunction and arrhythmias during acute cardiac rejection. Methods and Results: Heterotopic heart transplantation was performed in allogeneic and...
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| Autor*in: |
BABUTY, DOMINIQUE - M.D., PH.D. [verfasserIn] OJEDA, CARLOS - PH.D. [verfasserIn] MACHET, MARIE-CHRISTINE - M.D. [verfasserIn] AUPART, MICHEL - M.D. COSNAY, PIERRE - M.D. FAUCHIER, JEAN-PAUL - M.D. GARNIER, DIDIER - PH.D |
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| Format: |
E-Artikel |
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| Erschienen: |
Oxford, UK: Blackwell Publishing Ltd ; 1998 |
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| Schlagwörter: |
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| Umfang: |
Online-Ressource |
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| Reproduktion: |
2007 ; Blackwell Publishing Journal Backfiles 1879-2005 |
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| Übergeordnetes Werk: |
In: Journal of cardiovascular electrophysiology - Oxford : Wiley-Blackwell, 1990, 9(1998), 10, Seite 0 |
| Übergeordnetes Werk: |
volume:9 ; year:1998 ; number:10 ; pages:0 |
| Links: |
|---|
| DOI / URN: |
10.1111/j.1540-8167.1998.tb00885.x |
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| 520 | |a Alteration of Cardiac Action Potential. Introduction: Alteration of cardiac action potential and its adaptation to heart rate could contribute to cardiac dysfunction and arrhythmias during acute cardiac rejection. Methods and Results: Heterotopic heart transplantation was performed in allogeneic and syngeneic rats in which the action potentials of right and left ventricles were measured at 1, 2.5, 3.3, and 5.7 Hz successively using standard microelectrode techniques and compared with nontransplanted hearts. For each frequency, we measured action potential amplitude, action potential duration, transmembrane resting potential, and Vmax. In the right ventricle, at 1 Hz in the presence of rejection (n = 40), a significant increase was observed in action potential duration at 20%, 50%, and 70% repolarization (82.5%, 75.6%, and 70.8%, respectively) and in action potential amplitude (+17.9 mV), and the resting potential was decreased (-5.3 mV). A lack of adaptation of action potential duration to the driving frequency was observed in the rejecting heart group in contrast to controls (n = 20) and nourejecting hearts (n = 13). Similar results were observed in the left ventricle and surprisingly in the native hearts (n = 11) of recipients with allografted rejecting hearts in the abdominal position. Conclusion: Action potential and its adaptation to the driving frequency is considerably altered during acute rejection. A humoral factor could contribute to cardiac dysfunction. | ||
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10.1111/j.1540-8167.1998.tb00885.x doi (DE-627)NLEJ243340281 DE-627 ger DE-627 rakwb BABUTY, DOMINIQUE M.D., PH.D. verfasserin aut Severe and Early Alteration of Action Potential During Acute Cardiac Rejection in Rats Oxford, UK Blackwell Publishing Ltd 1998 Online-Ressource nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Alteration of Cardiac Action Potential. Introduction: Alteration of cardiac action potential and its adaptation to heart rate could contribute to cardiac dysfunction and arrhythmias during acute cardiac rejection. Methods and Results: Heterotopic heart transplantation was performed in allogeneic and syngeneic rats in which the action potentials of right and left ventricles were measured at 1, 2.5, 3.3, and 5.7 Hz successively using standard microelectrode techniques and compared with nontransplanted hearts. For each frequency, we measured action potential amplitude, action potential duration, transmembrane resting potential, and Vmax. In the right ventricle, at 1 Hz in the presence of rejection (n = 40), a significant increase was observed in action potential duration at 20%, 50%, and 70% repolarization (82.5%, 75.6%, and 70.8%, respectively) and in action potential amplitude (+17.9 mV), and the resting potential was decreased (-5.3 mV). A lack of adaptation of action potential duration to the driving frequency was observed in the rejecting heart group in contrast to controls (n = 20) and nourejecting hearts (n = 13). Similar results were observed in the left ventricle and surprisingly in the native hearts (n = 11) of recipients with allografted rejecting hearts in the abdominal position. Conclusion: Action potential and its adaptation to the driving frequency is considerably altered during acute rejection. A humoral factor could contribute to cardiac dysfunction. 2007 Blackwell Publishing Journal Backfiles 1879-2005 |2007|||||||||| transplantation OJEDA, CARLOS PH.D. verfasserin aut MACHET, MARIE-CHRISTINE M.D. verfasserin aut AUPART, MICHEL M.D. oth COSNAY, PIERRE M.D. oth FAUCHIER, JEAN-PAUL M.D. oth GARNIER, DIDIER PH.D oth In Journal of cardiovascular electrophysiology Oxford : Wiley-Blackwell, 1990 9(1998), 10, Seite 0 Online-Ressource (DE-627)NLEJ243926243 (DE-600)2037519-0 1540-8167 nnns volume:9 year:1998 number:10 pages:0 http://dx.doi.org/10.1111/j.1540-8167.1998.tb00885.x text/html Verlag Deutschlandweit zugänglich Volltext GBV_USEFLAG_U ZDB-1-DJB GBV_NL_ARTICLE AR 9 1998 10 0 |
| spelling |
10.1111/j.1540-8167.1998.tb00885.x doi (DE-627)NLEJ243340281 DE-627 ger DE-627 rakwb BABUTY, DOMINIQUE M.D., PH.D. verfasserin aut Severe and Early Alteration of Action Potential During Acute Cardiac Rejection in Rats Oxford, UK Blackwell Publishing Ltd 1998 Online-Ressource nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Alteration of Cardiac Action Potential. Introduction: Alteration of cardiac action potential and its adaptation to heart rate could contribute to cardiac dysfunction and arrhythmias during acute cardiac rejection. Methods and Results: Heterotopic heart transplantation was performed in allogeneic and syngeneic rats in which the action potentials of right and left ventricles were measured at 1, 2.5, 3.3, and 5.7 Hz successively using standard microelectrode techniques and compared with nontransplanted hearts. For each frequency, we measured action potential amplitude, action potential duration, transmembrane resting potential, and Vmax. In the right ventricle, at 1 Hz in the presence of rejection (n = 40), a significant increase was observed in action potential duration at 20%, 50%, and 70% repolarization (82.5%, 75.6%, and 70.8%, respectively) and in action potential amplitude (+17.9 mV), and the resting potential was decreased (-5.3 mV). A lack of adaptation of action potential duration to the driving frequency was observed in the rejecting heart group in contrast to controls (n = 20) and nourejecting hearts (n = 13). Similar results were observed in the left ventricle and surprisingly in the native hearts (n = 11) of recipients with allografted rejecting hearts in the abdominal position. Conclusion: Action potential and its adaptation to the driving frequency is considerably altered during acute rejection. A humoral factor could contribute to cardiac dysfunction. 2007 Blackwell Publishing Journal Backfiles 1879-2005 |2007|||||||||| transplantation OJEDA, CARLOS PH.D. verfasserin aut MACHET, MARIE-CHRISTINE M.D. verfasserin aut AUPART, MICHEL M.D. oth COSNAY, PIERRE M.D. oth FAUCHIER, JEAN-PAUL M.D. oth GARNIER, DIDIER PH.D oth In Journal of cardiovascular electrophysiology Oxford : Wiley-Blackwell, 1990 9(1998), 10, Seite 0 Online-Ressource (DE-627)NLEJ243926243 (DE-600)2037519-0 1540-8167 nnns volume:9 year:1998 number:10 pages:0 http://dx.doi.org/10.1111/j.1540-8167.1998.tb00885.x text/html Verlag Deutschlandweit zugänglich Volltext GBV_USEFLAG_U ZDB-1-DJB GBV_NL_ARTICLE AR 9 1998 10 0 |
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10.1111/j.1540-8167.1998.tb00885.x doi (DE-627)NLEJ243340281 DE-627 ger DE-627 rakwb BABUTY, DOMINIQUE M.D., PH.D. verfasserin aut Severe and Early Alteration of Action Potential During Acute Cardiac Rejection in Rats Oxford, UK Blackwell Publishing Ltd 1998 Online-Ressource nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Alteration of Cardiac Action Potential. Introduction: Alteration of cardiac action potential and its adaptation to heart rate could contribute to cardiac dysfunction and arrhythmias during acute cardiac rejection. Methods and Results: Heterotopic heart transplantation was performed in allogeneic and syngeneic rats in which the action potentials of right and left ventricles were measured at 1, 2.5, 3.3, and 5.7 Hz successively using standard microelectrode techniques and compared with nontransplanted hearts. For each frequency, we measured action potential amplitude, action potential duration, transmembrane resting potential, and Vmax. In the right ventricle, at 1 Hz in the presence of rejection (n = 40), a significant increase was observed in action potential duration at 20%, 50%, and 70% repolarization (82.5%, 75.6%, and 70.8%, respectively) and in action potential amplitude (+17.9 mV), and the resting potential was decreased (-5.3 mV). A lack of adaptation of action potential duration to the driving frequency was observed in the rejecting heart group in contrast to controls (n = 20) and nourejecting hearts (n = 13). Similar results were observed in the left ventricle and surprisingly in the native hearts (n = 11) of recipients with allografted rejecting hearts in the abdominal position. Conclusion: Action potential and its adaptation to the driving frequency is considerably altered during acute rejection. A humoral factor could contribute to cardiac dysfunction. 2007 Blackwell Publishing Journal Backfiles 1879-2005 |2007|||||||||| transplantation OJEDA, CARLOS PH.D. verfasserin aut MACHET, MARIE-CHRISTINE M.D. verfasserin aut AUPART, MICHEL M.D. oth COSNAY, PIERRE M.D. oth FAUCHIER, JEAN-PAUL M.D. oth GARNIER, DIDIER PH.D oth In Journal of cardiovascular electrophysiology Oxford : Wiley-Blackwell, 1990 9(1998), 10, Seite 0 Online-Ressource (DE-627)NLEJ243926243 (DE-600)2037519-0 1540-8167 nnns volume:9 year:1998 number:10 pages:0 http://dx.doi.org/10.1111/j.1540-8167.1998.tb00885.x text/html Verlag Deutschlandweit zugänglich Volltext GBV_USEFLAG_U ZDB-1-DJB GBV_NL_ARTICLE AR 9 1998 10 0 |
| allfieldsGer |
10.1111/j.1540-8167.1998.tb00885.x doi (DE-627)NLEJ243340281 DE-627 ger DE-627 rakwb BABUTY, DOMINIQUE M.D., PH.D. verfasserin aut Severe and Early Alteration of Action Potential During Acute Cardiac Rejection in Rats Oxford, UK Blackwell Publishing Ltd 1998 Online-Ressource nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Alteration of Cardiac Action Potential. Introduction: Alteration of cardiac action potential and its adaptation to heart rate could contribute to cardiac dysfunction and arrhythmias during acute cardiac rejection. Methods and Results: Heterotopic heart transplantation was performed in allogeneic and syngeneic rats in which the action potentials of right and left ventricles were measured at 1, 2.5, 3.3, and 5.7 Hz successively using standard microelectrode techniques and compared with nontransplanted hearts. For each frequency, we measured action potential amplitude, action potential duration, transmembrane resting potential, and Vmax. In the right ventricle, at 1 Hz in the presence of rejection (n = 40), a significant increase was observed in action potential duration at 20%, 50%, and 70% repolarization (82.5%, 75.6%, and 70.8%, respectively) and in action potential amplitude (+17.9 mV), and the resting potential was decreased (-5.3 mV). A lack of adaptation of action potential duration to the driving frequency was observed in the rejecting heart group in contrast to controls (n = 20) and nourejecting hearts (n = 13). Similar results were observed in the left ventricle and surprisingly in the native hearts (n = 11) of recipients with allografted rejecting hearts in the abdominal position. Conclusion: Action potential and its adaptation to the driving frequency is considerably altered during acute rejection. A humoral factor could contribute to cardiac dysfunction. 2007 Blackwell Publishing Journal Backfiles 1879-2005 |2007|||||||||| transplantation OJEDA, CARLOS PH.D. verfasserin aut MACHET, MARIE-CHRISTINE M.D. verfasserin aut AUPART, MICHEL M.D. oth COSNAY, PIERRE M.D. oth FAUCHIER, JEAN-PAUL M.D. oth GARNIER, DIDIER PH.D oth In Journal of cardiovascular electrophysiology Oxford : Wiley-Blackwell, 1990 9(1998), 10, Seite 0 Online-Ressource (DE-627)NLEJ243926243 (DE-600)2037519-0 1540-8167 nnns volume:9 year:1998 number:10 pages:0 http://dx.doi.org/10.1111/j.1540-8167.1998.tb00885.x text/html Verlag Deutschlandweit zugänglich Volltext GBV_USEFLAG_U ZDB-1-DJB GBV_NL_ARTICLE AR 9 1998 10 0 |
| allfieldsSound |
10.1111/j.1540-8167.1998.tb00885.x doi (DE-627)NLEJ243340281 DE-627 ger DE-627 rakwb BABUTY, DOMINIQUE M.D., PH.D. verfasserin aut Severe and Early Alteration of Action Potential During Acute Cardiac Rejection in Rats Oxford, UK Blackwell Publishing Ltd 1998 Online-Ressource nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Alteration of Cardiac Action Potential. Introduction: Alteration of cardiac action potential and its adaptation to heart rate could contribute to cardiac dysfunction and arrhythmias during acute cardiac rejection. Methods and Results: Heterotopic heart transplantation was performed in allogeneic and syngeneic rats in which the action potentials of right and left ventricles were measured at 1, 2.5, 3.3, and 5.7 Hz successively using standard microelectrode techniques and compared with nontransplanted hearts. For each frequency, we measured action potential amplitude, action potential duration, transmembrane resting potential, and Vmax. In the right ventricle, at 1 Hz in the presence of rejection (n = 40), a significant increase was observed in action potential duration at 20%, 50%, and 70% repolarization (82.5%, 75.6%, and 70.8%, respectively) and in action potential amplitude (+17.9 mV), and the resting potential was decreased (-5.3 mV). A lack of adaptation of action potential duration to the driving frequency was observed in the rejecting heart group in contrast to controls (n = 20) and nourejecting hearts (n = 13). Similar results were observed in the left ventricle and surprisingly in the native hearts (n = 11) of recipients with allografted rejecting hearts in the abdominal position. Conclusion: Action potential and its adaptation to the driving frequency is considerably altered during acute rejection. A humoral factor could contribute to cardiac dysfunction. 2007 Blackwell Publishing Journal Backfiles 1879-2005 |2007|||||||||| transplantation OJEDA, CARLOS PH.D. verfasserin aut MACHET, MARIE-CHRISTINE M.D. verfasserin aut AUPART, MICHEL M.D. oth COSNAY, PIERRE M.D. oth FAUCHIER, JEAN-PAUL M.D. oth GARNIER, DIDIER PH.D oth In Journal of cardiovascular electrophysiology Oxford : Wiley-Blackwell, 1990 9(1998), 10, Seite 0 Online-Ressource (DE-627)NLEJ243926243 (DE-600)2037519-0 1540-8167 nnns volume:9 year:1998 number:10 pages:0 http://dx.doi.org/10.1111/j.1540-8167.1998.tb00885.x text/html Verlag Deutschlandweit zugänglich Volltext GBV_USEFLAG_U ZDB-1-DJB GBV_NL_ARTICLE AR 9 1998 10 0 |
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BABUTY, DOMINIQUE OJEDA, CARLOS MACHET, MARIE-CHRISTINE |
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9 |
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Elektronische Aufsätze |
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BABUTY, DOMINIQUE |
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10.1111/j.1540-8167.1998.tb00885.x |
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verfasserin |
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severe and early alteration of action potential during acute cardiac rejection in rats |
| title_auth |
Severe and Early Alteration of Action Potential During Acute Cardiac Rejection in Rats |
| abstract |
Alteration of Cardiac Action Potential. Introduction: Alteration of cardiac action potential and its adaptation to heart rate could contribute to cardiac dysfunction and arrhythmias during acute cardiac rejection. Methods and Results: Heterotopic heart transplantation was performed in allogeneic and syngeneic rats in which the action potentials of right and left ventricles were measured at 1, 2.5, 3.3, and 5.7 Hz successively using standard microelectrode techniques and compared with nontransplanted hearts. For each frequency, we measured action potential amplitude, action potential duration, transmembrane resting potential, and Vmax. In the right ventricle, at 1 Hz in the presence of rejection (n = 40), a significant increase was observed in action potential duration at 20%, 50%, and 70% repolarization (82.5%, 75.6%, and 70.8%, respectively) and in action potential amplitude (+17.9 mV), and the resting potential was decreased (-5.3 mV). A lack of adaptation of action potential duration to the driving frequency was observed in the rejecting heart group in contrast to controls (n = 20) and nourejecting hearts (n = 13). Similar results were observed in the left ventricle and surprisingly in the native hearts (n = 11) of recipients with allografted rejecting hearts in the abdominal position. Conclusion: Action potential and its adaptation to the driving frequency is considerably altered during acute rejection. A humoral factor could contribute to cardiac dysfunction. |
| abstractGer |
Alteration of Cardiac Action Potential. Introduction: Alteration of cardiac action potential and its adaptation to heart rate could contribute to cardiac dysfunction and arrhythmias during acute cardiac rejection. Methods and Results: Heterotopic heart transplantation was performed in allogeneic and syngeneic rats in which the action potentials of right and left ventricles were measured at 1, 2.5, 3.3, and 5.7 Hz successively using standard microelectrode techniques and compared with nontransplanted hearts. For each frequency, we measured action potential amplitude, action potential duration, transmembrane resting potential, and Vmax. In the right ventricle, at 1 Hz in the presence of rejection (n = 40), a significant increase was observed in action potential duration at 20%, 50%, and 70% repolarization (82.5%, 75.6%, and 70.8%, respectively) and in action potential amplitude (+17.9 mV), and the resting potential was decreased (-5.3 mV). A lack of adaptation of action potential duration to the driving frequency was observed in the rejecting heart group in contrast to controls (n = 20) and nourejecting hearts (n = 13). Similar results were observed in the left ventricle and surprisingly in the native hearts (n = 11) of recipients with allografted rejecting hearts in the abdominal position. Conclusion: Action potential and its adaptation to the driving frequency is considerably altered during acute rejection. A humoral factor could contribute to cardiac dysfunction. |
| abstract_unstemmed |
Alteration of Cardiac Action Potential. Introduction: Alteration of cardiac action potential and its adaptation to heart rate could contribute to cardiac dysfunction and arrhythmias during acute cardiac rejection. Methods and Results: Heterotopic heart transplantation was performed in allogeneic and syngeneic rats in which the action potentials of right and left ventricles were measured at 1, 2.5, 3.3, and 5.7 Hz successively using standard microelectrode techniques and compared with nontransplanted hearts. For each frequency, we measured action potential amplitude, action potential duration, transmembrane resting potential, and Vmax. In the right ventricle, at 1 Hz in the presence of rejection (n = 40), a significant increase was observed in action potential duration at 20%, 50%, and 70% repolarization (82.5%, 75.6%, and 70.8%, respectively) and in action potential amplitude (+17.9 mV), and the resting potential was decreased (-5.3 mV). A lack of adaptation of action potential duration to the driving frequency was observed in the rejecting heart group in contrast to controls (n = 20) and nourejecting hearts (n = 13). Similar results were observed in the left ventricle and surprisingly in the native hearts (n = 11) of recipients with allografted rejecting hearts in the abdominal position. Conclusion: Action potential and its adaptation to the driving frequency is considerably altered during acute rejection. A humoral factor could contribute to cardiac dysfunction. |
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Severe and Early Alteration of Action Potential During Acute Cardiac Rejection in Rats |
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OJEDA, CARLOS PH.D. MACHET, MARIE-CHRISTINE M.D. AUPART, MICHEL M.D. COSNAY, PIERRE M.D. FAUCHIER, JEAN-PAUL M.D. GARNIER, DIDIER PH.D |
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OJEDA, CARLOS PH.D. MACHET, MARIE-CHRISTINE M.D. AUPART, MICHEL M.D. COSNAY, PIERRE M.D. FAUCHIER, JEAN-PAUL M.D. GARNIER, DIDIER PH.D |
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