Site-Specific Arrhythmogenesis in Patients with Brugada Syndrome
Introduction: It has been believed that electrophysiologic abnormality of the epicardial region of the right ventricular free wall may play an important role in arrhythmogenesis of phase 2 reentry in Brugada syndrome, but clinical evidence of the occurrence of ventricular arrhythmias at the right ve...
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MORITA, HIROSHI - M.D. FUKUSHIMA-KUSANO, KENGO - M.D. NAGASE, SATOSHI - M.D. TAKENAKA-MORITA, SHIHO - M.D. NISHII, NOBUHIRO - M.D. KAKISHITA, MIKIO - M.D. NAKAMURA, KAZUFUMI - M.D. EMORI, TETSURO - M.D. MATSUBARA, HIROMI - M.D. OHE, TOHRU - M.D. |
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350 Main Street , Malden , MA 02148 , USA , and 9600 Garsington Road , Oxford OX4 2DQ , UK .: Blackwell Science Inc ; 2003 |
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Online-Ressource |
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2003 ; Blackwell Publishing Journal Backfiles 1879-2005 |
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In: Journal of cardiovascular electrophysiology - Oxford : Wiley-Blackwell, 1990, 14(2003), 4, Seite 0 |
| Übergeordnetes Werk: |
volume:14 ; year:2003 ; number:4 ; pages:0 |
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| DOI / URN: |
10.1046/j.1540-8167.2003.02365.x |
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| 245 | 1 | 0 | |a Site-Specific Arrhythmogenesis in Patients with Brugada Syndrome |
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| 520 | |a Introduction: It has been believed that electrophysiologic abnormality of the epicardial region of the right ventricular free wall may play an important role in arrhythmogenesis of phase 2 reentry in Brugada syndrome, but clinical evidence of the occurrence of ventricular arrhythmias at the right ventricular free wall has not been evaluated. In this study, we evaluated the site-specific inducibility of ventricular fibrillation (VF) and the origin of spontaneous premature ventricular contractions (PVCs) in patients with Brugada syndrome. Methods and Results. Forty-five patients with Brugada-type ECG were enrolled in this study. Spontaneous PVCs were recorded in 9 patients. Programmed electrical stimulation (PES) was performed at the right ventricular apex (RVA), the free wall and septal region of the right ventricular outflow tract (RVOT), and the left ventricle (LV). The inducibility of PVT/VF was evaluated at each ventricular site, and the origin of PVC was determined by pace mapping. Sustained VF was induced in 17 patients. VF was induced in all 17 patients by PES at RVOT. Although PES at the septal region of the RVOT induced VF in only 5 patients (29%), PES at the free-wall region of the RVOT induced PVT/VF in 13 patients (76%). PES at RVA induced VF in only 2 patients (12%), and PES at LV failed to induce any arrhythmic events. Ventricular pace mapping showed that 64% of PVCs occurred at the free-wall region of the RVOT, 18% at the septal region of the RVOT, 9% at RVA, and 9% at LV. Conclusion: VF in patients with Brugada syndrome frequently is induced at the free-wall region of the RVOT area. The origin of PVC appears to be related to the site of PVT/VF induction by PES. (J Cardiovasc Electrophysiol, Vol. 14, pp. 373-379, April 2003) | ||
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| 700 | 1 | |a MORITA, HIROSHI |c M.D. |4 oth | |
| 700 | 1 | |a FUKUSHIMA-KUSANO, KENGO |c M.D. |4 oth | |
| 700 | 1 | |a NAGASE, SATOSHI |c M.D. |4 oth | |
| 700 | 1 | |a TAKENAKA-MORITA, SHIHO |c M.D. |4 oth | |
| 700 | 1 | |a NISHII, NOBUHIRO |c M.D. |4 oth | |
| 700 | 1 | |a KAKISHITA, MIKIO |c M.D. |4 oth | |
| 700 | 1 | |a NAKAMURA, KAZUFUMI |c M.D. |4 oth | |
| 700 | 1 | |a EMORI, TETSURO |c M.D. |4 oth | |
| 700 | 1 | |a MATSUBARA, HIROMI |c M.D. |4 oth | |
| 700 | 1 | |a OHE, TOHRU |c M.D. |4 oth | |
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10.1046/j.1540-8167.2003.02365.x doi (DE-627)NLEJ243350325 DE-627 ger DE-627 rakwb Site-Specific Arrhythmogenesis in Patients with Brugada Syndrome 350 Main Street , Malden , MA 02148 , USA , and 9600 Garsington Road , Oxford OX4 2DQ , UK . Blackwell Science Inc 2003 Online-Ressource nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Introduction: It has been believed that electrophysiologic abnormality of the epicardial region of the right ventricular free wall may play an important role in arrhythmogenesis of phase 2 reentry in Brugada syndrome, but clinical evidence of the occurrence of ventricular arrhythmias at the right ventricular free wall has not been evaluated. In this study, we evaluated the site-specific inducibility of ventricular fibrillation (VF) and the origin of spontaneous premature ventricular contractions (PVCs) in patients with Brugada syndrome. Methods and Results. Forty-five patients with Brugada-type ECG were enrolled in this study. Spontaneous PVCs were recorded in 9 patients. Programmed electrical stimulation (PES) was performed at the right ventricular apex (RVA), the free wall and septal region of the right ventricular outflow tract (RVOT), and the left ventricle (LV). The inducibility of PVT/VF was evaluated at each ventricular site, and the origin of PVC was determined by pace mapping. Sustained VF was induced in 17 patients. VF was induced in all 17 patients by PES at RVOT. Although PES at the septal region of the RVOT induced VF in only 5 patients (29%), PES at the free-wall region of the RVOT induced PVT/VF in 13 patients (76%). PES at RVA induced VF in only 2 patients (12%), and PES at LV failed to induce any arrhythmic events. Ventricular pace mapping showed that 64% of PVCs occurred at the free-wall region of the RVOT, 18% at the septal region of the RVOT, 9% at RVA, and 9% at LV. Conclusion: VF in patients with Brugada syndrome frequently is induced at the free-wall region of the RVOT area. The origin of PVC appears to be related to the site of PVT/VF induction by PES. (J Cardiovasc Electrophysiol, Vol. 14, pp. 373-379, April 2003) 2003 Blackwell Publishing Journal Backfiles 1879-2005 |2003|||||||||| MORITA, HIROSHI M.D. oth FUKUSHIMA-KUSANO, KENGO M.D. oth NAGASE, SATOSHI M.D. oth TAKENAKA-MORITA, SHIHO M.D. oth NISHII, NOBUHIRO M.D. oth KAKISHITA, MIKIO M.D. oth NAKAMURA, KAZUFUMI M.D. oth EMORI, TETSURO M.D. oth MATSUBARA, HIROMI M.D. oth OHE, TOHRU M.D. oth In Journal of cardiovascular electrophysiology Oxford : Wiley-Blackwell, 1990 14(2003), 4, Seite 0 Online-Ressource (DE-627)NLEJ243926243 (DE-600)2037519-0 1540-8167 nnns volume:14 year:2003 number:4 pages:0 http://dx.doi.org/10.1046/j.1540-8167.2003.02365.x text/html Verlag Deutschlandweit zugänglich Volltext GBV_USEFLAG_U ZDB-1-DJB GBV_NL_ARTICLE AR 14 2003 4 0 |
| spelling |
10.1046/j.1540-8167.2003.02365.x doi (DE-627)NLEJ243350325 DE-627 ger DE-627 rakwb Site-Specific Arrhythmogenesis in Patients with Brugada Syndrome 350 Main Street , Malden , MA 02148 , USA , and 9600 Garsington Road , Oxford OX4 2DQ , UK . Blackwell Science Inc 2003 Online-Ressource nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Introduction: It has been believed that electrophysiologic abnormality of the epicardial region of the right ventricular free wall may play an important role in arrhythmogenesis of phase 2 reentry in Brugada syndrome, but clinical evidence of the occurrence of ventricular arrhythmias at the right ventricular free wall has not been evaluated. In this study, we evaluated the site-specific inducibility of ventricular fibrillation (VF) and the origin of spontaneous premature ventricular contractions (PVCs) in patients with Brugada syndrome. Methods and Results. Forty-five patients with Brugada-type ECG were enrolled in this study. Spontaneous PVCs were recorded in 9 patients. Programmed electrical stimulation (PES) was performed at the right ventricular apex (RVA), the free wall and septal region of the right ventricular outflow tract (RVOT), and the left ventricle (LV). The inducibility of PVT/VF was evaluated at each ventricular site, and the origin of PVC was determined by pace mapping. Sustained VF was induced in 17 patients. VF was induced in all 17 patients by PES at RVOT. Although PES at the septal region of the RVOT induced VF in only 5 patients (29%), PES at the free-wall region of the RVOT induced PVT/VF in 13 patients (76%). PES at RVA induced VF in only 2 patients (12%), and PES at LV failed to induce any arrhythmic events. Ventricular pace mapping showed that 64% of PVCs occurred at the free-wall region of the RVOT, 18% at the septal region of the RVOT, 9% at RVA, and 9% at LV. Conclusion: VF in patients with Brugada syndrome frequently is induced at the free-wall region of the RVOT area. The origin of PVC appears to be related to the site of PVT/VF induction by PES. (J Cardiovasc Electrophysiol, Vol. 14, pp. 373-379, April 2003) 2003 Blackwell Publishing Journal Backfiles 1879-2005 |2003|||||||||| MORITA, HIROSHI M.D. oth FUKUSHIMA-KUSANO, KENGO M.D. oth NAGASE, SATOSHI M.D. oth TAKENAKA-MORITA, SHIHO M.D. oth NISHII, NOBUHIRO M.D. oth KAKISHITA, MIKIO M.D. oth NAKAMURA, KAZUFUMI M.D. oth EMORI, TETSURO M.D. oth MATSUBARA, HIROMI M.D. oth OHE, TOHRU M.D. oth In Journal of cardiovascular electrophysiology Oxford : Wiley-Blackwell, 1990 14(2003), 4, Seite 0 Online-Ressource (DE-627)NLEJ243926243 (DE-600)2037519-0 1540-8167 nnns volume:14 year:2003 number:4 pages:0 http://dx.doi.org/10.1046/j.1540-8167.2003.02365.x text/html Verlag Deutschlandweit zugänglich Volltext GBV_USEFLAG_U ZDB-1-DJB GBV_NL_ARTICLE AR 14 2003 4 0 |
| allfields_unstemmed |
10.1046/j.1540-8167.2003.02365.x doi (DE-627)NLEJ243350325 DE-627 ger DE-627 rakwb Site-Specific Arrhythmogenesis in Patients with Brugada Syndrome 350 Main Street , Malden , MA 02148 , USA , and 9600 Garsington Road , Oxford OX4 2DQ , UK . Blackwell Science Inc 2003 Online-Ressource nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Introduction: It has been believed that electrophysiologic abnormality of the epicardial region of the right ventricular free wall may play an important role in arrhythmogenesis of phase 2 reentry in Brugada syndrome, but clinical evidence of the occurrence of ventricular arrhythmias at the right ventricular free wall has not been evaluated. In this study, we evaluated the site-specific inducibility of ventricular fibrillation (VF) and the origin of spontaneous premature ventricular contractions (PVCs) in patients with Brugada syndrome. Methods and Results. Forty-five patients with Brugada-type ECG were enrolled in this study. Spontaneous PVCs were recorded in 9 patients. Programmed electrical stimulation (PES) was performed at the right ventricular apex (RVA), the free wall and septal region of the right ventricular outflow tract (RVOT), and the left ventricle (LV). The inducibility of PVT/VF was evaluated at each ventricular site, and the origin of PVC was determined by pace mapping. Sustained VF was induced in 17 patients. VF was induced in all 17 patients by PES at RVOT. Although PES at the septal region of the RVOT induced VF in only 5 patients (29%), PES at the free-wall region of the RVOT induced PVT/VF in 13 patients (76%). PES at RVA induced VF in only 2 patients (12%), and PES at LV failed to induce any arrhythmic events. Ventricular pace mapping showed that 64% of PVCs occurred at the free-wall region of the RVOT, 18% at the septal region of the RVOT, 9% at RVA, and 9% at LV. Conclusion: VF in patients with Brugada syndrome frequently is induced at the free-wall region of the RVOT area. The origin of PVC appears to be related to the site of PVT/VF induction by PES. (J Cardiovasc Electrophysiol, Vol. 14, pp. 373-379, April 2003) 2003 Blackwell Publishing Journal Backfiles 1879-2005 |2003|||||||||| MORITA, HIROSHI M.D. oth FUKUSHIMA-KUSANO, KENGO M.D. oth NAGASE, SATOSHI M.D. oth TAKENAKA-MORITA, SHIHO M.D. oth NISHII, NOBUHIRO M.D. oth KAKISHITA, MIKIO M.D. oth NAKAMURA, KAZUFUMI M.D. oth EMORI, TETSURO M.D. oth MATSUBARA, HIROMI M.D. oth OHE, TOHRU M.D. oth In Journal of cardiovascular electrophysiology Oxford : Wiley-Blackwell, 1990 14(2003), 4, Seite 0 Online-Ressource (DE-627)NLEJ243926243 (DE-600)2037519-0 1540-8167 nnns volume:14 year:2003 number:4 pages:0 http://dx.doi.org/10.1046/j.1540-8167.2003.02365.x text/html Verlag Deutschlandweit zugänglich Volltext GBV_USEFLAG_U ZDB-1-DJB GBV_NL_ARTICLE AR 14 2003 4 0 |
| allfieldsGer |
10.1046/j.1540-8167.2003.02365.x doi (DE-627)NLEJ243350325 DE-627 ger DE-627 rakwb Site-Specific Arrhythmogenesis in Patients with Brugada Syndrome 350 Main Street , Malden , MA 02148 , USA , and 9600 Garsington Road , Oxford OX4 2DQ , UK . Blackwell Science Inc 2003 Online-Ressource nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Introduction: It has been believed that electrophysiologic abnormality of the epicardial region of the right ventricular free wall may play an important role in arrhythmogenesis of phase 2 reentry in Brugada syndrome, but clinical evidence of the occurrence of ventricular arrhythmias at the right ventricular free wall has not been evaluated. In this study, we evaluated the site-specific inducibility of ventricular fibrillation (VF) and the origin of spontaneous premature ventricular contractions (PVCs) in patients with Brugada syndrome. Methods and Results. Forty-five patients with Brugada-type ECG were enrolled in this study. Spontaneous PVCs were recorded in 9 patients. Programmed electrical stimulation (PES) was performed at the right ventricular apex (RVA), the free wall and septal region of the right ventricular outflow tract (RVOT), and the left ventricle (LV). The inducibility of PVT/VF was evaluated at each ventricular site, and the origin of PVC was determined by pace mapping. Sustained VF was induced in 17 patients. VF was induced in all 17 patients by PES at RVOT. Although PES at the septal region of the RVOT induced VF in only 5 patients (29%), PES at the free-wall region of the RVOT induced PVT/VF in 13 patients (76%). PES at RVA induced VF in only 2 patients (12%), and PES at LV failed to induce any arrhythmic events. Ventricular pace mapping showed that 64% of PVCs occurred at the free-wall region of the RVOT, 18% at the septal region of the RVOT, 9% at RVA, and 9% at LV. Conclusion: VF in patients with Brugada syndrome frequently is induced at the free-wall region of the RVOT area. The origin of PVC appears to be related to the site of PVT/VF induction by PES. (J Cardiovasc Electrophysiol, Vol. 14, pp. 373-379, April 2003) 2003 Blackwell Publishing Journal Backfiles 1879-2005 |2003|||||||||| MORITA, HIROSHI M.D. oth FUKUSHIMA-KUSANO, KENGO M.D. oth NAGASE, SATOSHI M.D. oth TAKENAKA-MORITA, SHIHO M.D. oth NISHII, NOBUHIRO M.D. oth KAKISHITA, MIKIO M.D. oth NAKAMURA, KAZUFUMI M.D. oth EMORI, TETSURO M.D. oth MATSUBARA, HIROMI M.D. oth OHE, TOHRU M.D. oth In Journal of cardiovascular electrophysiology Oxford : Wiley-Blackwell, 1990 14(2003), 4, Seite 0 Online-Ressource (DE-627)NLEJ243926243 (DE-600)2037519-0 1540-8167 nnns volume:14 year:2003 number:4 pages:0 http://dx.doi.org/10.1046/j.1540-8167.2003.02365.x text/html Verlag Deutschlandweit zugänglich Volltext GBV_USEFLAG_U ZDB-1-DJB GBV_NL_ARTICLE AR 14 2003 4 0 |
| allfieldsSound |
10.1046/j.1540-8167.2003.02365.x doi (DE-627)NLEJ243350325 DE-627 ger DE-627 rakwb Site-Specific Arrhythmogenesis in Patients with Brugada Syndrome 350 Main Street , Malden , MA 02148 , USA , and 9600 Garsington Road , Oxford OX4 2DQ , UK . Blackwell Science Inc 2003 Online-Ressource nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Introduction: It has been believed that electrophysiologic abnormality of the epicardial region of the right ventricular free wall may play an important role in arrhythmogenesis of phase 2 reentry in Brugada syndrome, but clinical evidence of the occurrence of ventricular arrhythmias at the right ventricular free wall has not been evaluated. In this study, we evaluated the site-specific inducibility of ventricular fibrillation (VF) and the origin of spontaneous premature ventricular contractions (PVCs) in patients with Brugada syndrome. Methods and Results. Forty-five patients with Brugada-type ECG were enrolled in this study. Spontaneous PVCs were recorded in 9 patients. Programmed electrical stimulation (PES) was performed at the right ventricular apex (RVA), the free wall and septal region of the right ventricular outflow tract (RVOT), and the left ventricle (LV). The inducibility of PVT/VF was evaluated at each ventricular site, and the origin of PVC was determined by pace mapping. Sustained VF was induced in 17 patients. VF was induced in all 17 patients by PES at RVOT. Although PES at the septal region of the RVOT induced VF in only 5 patients (29%), PES at the free-wall region of the RVOT induced PVT/VF in 13 patients (76%). PES at RVA induced VF in only 2 patients (12%), and PES at LV failed to induce any arrhythmic events. Ventricular pace mapping showed that 64% of PVCs occurred at the free-wall region of the RVOT, 18% at the septal region of the RVOT, 9% at RVA, and 9% at LV. Conclusion: VF in patients with Brugada syndrome frequently is induced at the free-wall region of the RVOT area. The origin of PVC appears to be related to the site of PVT/VF induction by PES. (J Cardiovasc Electrophysiol, Vol. 14, pp. 373-379, April 2003) 2003 Blackwell Publishing Journal Backfiles 1879-2005 |2003|||||||||| MORITA, HIROSHI M.D. oth FUKUSHIMA-KUSANO, KENGO M.D. oth NAGASE, SATOSHI M.D. oth TAKENAKA-MORITA, SHIHO M.D. oth NISHII, NOBUHIRO M.D. oth KAKISHITA, MIKIO M.D. oth NAKAMURA, KAZUFUMI M.D. oth EMORI, TETSURO M.D. oth MATSUBARA, HIROMI M.D. oth OHE, TOHRU M.D. oth In Journal of cardiovascular electrophysiology Oxford : Wiley-Blackwell, 1990 14(2003), 4, Seite 0 Online-Ressource (DE-627)NLEJ243926243 (DE-600)2037519-0 1540-8167 nnns volume:14 year:2003 number:4 pages:0 http://dx.doi.org/10.1046/j.1540-8167.2003.02365.x text/html Verlag Deutschlandweit zugänglich Volltext GBV_USEFLAG_U ZDB-1-DJB GBV_NL_ARTICLE AR 14 2003 4 0 |
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MORITA, HIROSHI @@oth@@ FUKUSHIMA-KUSANO, KENGO @@oth@@ NAGASE, SATOSHI @@oth@@ TAKENAKA-MORITA, SHIHO @@oth@@ NISHII, NOBUHIRO @@oth@@ KAKISHITA, MIKIO @@oth@@ NAKAMURA, KAZUFUMI @@oth@@ EMORI, TETSURO @@oth@@ MATSUBARA, HIROMI @@oth@@ OHE, TOHRU @@oth@@ |
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<?xml version="1.0" encoding="UTF-8"?><collection xmlns="http://www.loc.gov/MARC21/slim"><record><leader>01000caa a22002652 4500</leader><controlfield tag="001">NLEJ243350325</controlfield><controlfield tag="003">DE-627</controlfield><controlfield tag="005">20210707175918.0</controlfield><controlfield tag="007">cr uuu---uuuuu</controlfield><controlfield tag="008">120427s2003 xx |||||o 00| ||und c</controlfield><datafield tag="024" ind1="7" ind2=" "><subfield code="a">10.1046/j.1540-8167.2003.02365.x</subfield><subfield code="2">doi</subfield></datafield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(DE-627)NLEJ243350325</subfield></datafield><datafield tag="040" ind1=" " ind2=" "><subfield code="a">DE-627</subfield><subfield code="b">ger</subfield><subfield code="c">DE-627</subfield><subfield code="e">rakwb</subfield></datafield><datafield tag="245" ind1="1" ind2="0"><subfield code="a">Site-Specific Arrhythmogenesis in Patients with Brugada Syndrome</subfield></datafield><datafield tag="264" ind1=" " ind2="1"><subfield code="a">350 Main Street , Malden , MA 02148 , USA , and 9600 Garsington Road , Oxford OX4 2DQ , UK .</subfield><subfield code="b">Blackwell Science Inc</subfield><subfield code="c">2003</subfield></datafield><datafield tag="300" ind1=" " ind2=" "><subfield code="a">Online-Ressource</subfield></datafield><datafield tag="336" ind1=" " ind2=" "><subfield code="a">nicht spezifiziert</subfield><subfield code="b">zzz</subfield><subfield code="2">rdacontent</subfield></datafield><datafield tag="337" ind1=" " ind2=" "><subfield code="a">nicht spezifiziert</subfield><subfield code="b">z</subfield><subfield code="2">rdamedia</subfield></datafield><datafield tag="338" ind1=" " ind2=" "><subfield code="a">nicht spezifiziert</subfield><subfield code="b">zu</subfield><subfield code="2">rdacarrier</subfield></datafield><datafield tag="520" ind1=" " ind2=" "><subfield code="a">Introduction: It has been believed that electrophysiologic abnormality of the epicardial region of the right ventricular free wall may play an important role in arrhythmogenesis of phase 2 reentry in Brugada syndrome, but clinical evidence of the occurrence of ventricular arrhythmias at the right ventricular free wall has not been evaluated. In this study, we evaluated the site-specific inducibility of ventricular fibrillation (VF) and the origin of spontaneous premature ventricular contractions (PVCs) in patients with Brugada syndrome. Methods and Results. Forty-five patients with Brugada-type ECG were enrolled in this study. Spontaneous PVCs were recorded in 9 patients. Programmed electrical stimulation (PES) was performed at the right ventricular apex (RVA), the free wall and septal region of the right ventricular outflow tract (RVOT), and the left ventricle (LV). The inducibility of PVT/VF was evaluated at each ventricular site, and the origin of PVC was determined by pace mapping. Sustained VF was induced in 17 patients. VF was induced in all 17 patients by PES at RVOT. Although PES at the septal region of the RVOT induced VF in only 5 patients (29%), PES at the free-wall region of the RVOT induced PVT/VF in 13 patients (76%). PES at RVA induced VF in only 2 patients (12%), and PES at LV failed to induce any arrhythmic events. Ventricular pace mapping showed that 64% of PVCs occurred at the free-wall region of the RVOT, 18% at the septal region of the RVOT, 9% at RVA, and 9% at LV. Conclusion: VF in patients with Brugada syndrome frequently is induced at the free-wall region of the RVOT area. The origin of PVC appears to be related to the site of PVT/VF induction by PES. 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Site-Specific Arrhythmogenesis in Patients with Brugada Syndrome |
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site-specific arrhythmogenesis in patients with brugada syndrome |
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Site-Specific Arrhythmogenesis in Patients with Brugada Syndrome |
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Introduction: It has been believed that electrophysiologic abnormality of the epicardial region of the right ventricular free wall may play an important role in arrhythmogenesis of phase 2 reentry in Brugada syndrome, but clinical evidence of the occurrence of ventricular arrhythmias at the right ventricular free wall has not been evaluated. In this study, we evaluated the site-specific inducibility of ventricular fibrillation (VF) and the origin of spontaneous premature ventricular contractions (PVCs) in patients with Brugada syndrome. Methods and Results. Forty-five patients with Brugada-type ECG were enrolled in this study. Spontaneous PVCs were recorded in 9 patients. Programmed electrical stimulation (PES) was performed at the right ventricular apex (RVA), the free wall and septal region of the right ventricular outflow tract (RVOT), and the left ventricle (LV). The inducibility of PVT/VF was evaluated at each ventricular site, and the origin of PVC was determined by pace mapping. Sustained VF was induced in 17 patients. VF was induced in all 17 patients by PES at RVOT. Although PES at the septal region of the RVOT induced VF in only 5 patients (29%), PES at the free-wall region of the RVOT induced PVT/VF in 13 patients (76%). PES at RVA induced VF in only 2 patients (12%), and PES at LV failed to induce any arrhythmic events. Ventricular pace mapping showed that 64% of PVCs occurred at the free-wall region of the RVOT, 18% at the septal region of the RVOT, 9% at RVA, and 9% at LV. Conclusion: VF in patients with Brugada syndrome frequently is induced at the free-wall region of the RVOT area. The origin of PVC appears to be related to the site of PVT/VF induction by PES. (J Cardiovasc Electrophysiol, Vol. 14, pp. 373-379, April 2003) |
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Introduction: It has been believed that electrophysiologic abnormality of the epicardial region of the right ventricular free wall may play an important role in arrhythmogenesis of phase 2 reentry in Brugada syndrome, but clinical evidence of the occurrence of ventricular arrhythmias at the right ventricular free wall has not been evaluated. In this study, we evaluated the site-specific inducibility of ventricular fibrillation (VF) and the origin of spontaneous premature ventricular contractions (PVCs) in patients with Brugada syndrome. Methods and Results. Forty-five patients with Brugada-type ECG were enrolled in this study. Spontaneous PVCs were recorded in 9 patients. Programmed electrical stimulation (PES) was performed at the right ventricular apex (RVA), the free wall and septal region of the right ventricular outflow tract (RVOT), and the left ventricle (LV). The inducibility of PVT/VF was evaluated at each ventricular site, and the origin of PVC was determined by pace mapping. Sustained VF was induced in 17 patients. VF was induced in all 17 patients by PES at RVOT. Although PES at the septal region of the RVOT induced VF in only 5 patients (29%), PES at the free-wall region of the RVOT induced PVT/VF in 13 patients (76%). PES at RVA induced VF in only 2 patients (12%), and PES at LV failed to induce any arrhythmic events. Ventricular pace mapping showed that 64% of PVCs occurred at the free-wall region of the RVOT, 18% at the septal region of the RVOT, 9% at RVA, and 9% at LV. Conclusion: VF in patients with Brugada syndrome frequently is induced at the free-wall region of the RVOT area. The origin of PVC appears to be related to the site of PVT/VF induction by PES. (J Cardiovasc Electrophysiol, Vol. 14, pp. 373-379, April 2003) |
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Introduction: It has been believed that electrophysiologic abnormality of the epicardial region of the right ventricular free wall may play an important role in arrhythmogenesis of phase 2 reentry in Brugada syndrome, but clinical evidence of the occurrence of ventricular arrhythmias at the right ventricular free wall has not been evaluated. In this study, we evaluated the site-specific inducibility of ventricular fibrillation (VF) and the origin of spontaneous premature ventricular contractions (PVCs) in patients with Brugada syndrome. Methods and Results. Forty-five patients with Brugada-type ECG were enrolled in this study. Spontaneous PVCs were recorded in 9 patients. Programmed electrical stimulation (PES) was performed at the right ventricular apex (RVA), the free wall and septal region of the right ventricular outflow tract (RVOT), and the left ventricle (LV). The inducibility of PVT/VF was evaluated at each ventricular site, and the origin of PVC was determined by pace mapping. Sustained VF was induced in 17 patients. VF was induced in all 17 patients by PES at RVOT. Although PES at the septal region of the RVOT induced VF in only 5 patients (29%), PES at the free-wall region of the RVOT induced PVT/VF in 13 patients (76%). PES at RVA induced VF in only 2 patients (12%), and PES at LV failed to induce any arrhythmic events. Ventricular pace mapping showed that 64% of PVCs occurred at the free-wall region of the RVOT, 18% at the septal region of the RVOT, 9% at RVA, and 9% at LV. Conclusion: VF in patients with Brugada syndrome frequently is induced at the free-wall region of the RVOT area. The origin of PVC appears to be related to the site of PVT/VF induction by PES. (J Cardiovasc Electrophysiol, Vol. 14, pp. 373-379, April 2003) |
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