Abnormal Sinus Node Function in Clinical Arrhythmias
Abnormal Sinus Node Function. To understand abnormal sinus node function in clinical atrial arrhythmias, it is essential to understand the normal function of the sinus node. Much of our understanding of the sinus node comes from work done in rabbits. In small animals, the node is a thin structure an...
Ausführliche Beschreibung
Gespeichert in:
| Autor*in: |
SCHUESSLER, RICHARD B. - Ph.D. [verfasserIn] |
|---|
| Format: |
E-Artikel |
|---|
| Erschienen: |
350 Main Street , Malden , MA 02148 , USA , and 9600 Garsington Road , Oxford OX4 2DQ , UK .: Blackwell Science Inc ; 2003 |
|---|
| Umfang: |
Online-Ressource |
|---|
| Reproduktion: |
2003 ; Blackwell Publishing Journal Backfiles 1879-2005 |
|---|---|
| Übergeordnetes Werk: |
In: Journal of cardiovascular electrophysiology - Oxford : Wiley-Blackwell, 1990, 14(2003), 2, Seite 0 |
| Übergeordnetes Werk: |
volume:14 ; year:2003 ; number:2 ; pages:0 |
| Links: |
|---|
| DOI / URN: |
10.1046/j.1540-8167.2003.02229.x |
|---|
| Katalog-ID: |
NLEJ243350848 |
|---|
| LEADER | 01000caa a22002652 4500 | ||
|---|---|---|---|
| 001 | NLEJ243350848 | ||
| 003 | DE-627 | ||
| 005 | 20210707175922.0 | ||
| 007 | cr uuu---uuuuu | ||
| 008 | 120427s2003 xx |||||o 00| ||und c | ||
| 024 | 7 | |a 10.1046/j.1540-8167.2003.02229.x |2 doi | |
| 035 | |a (DE-627)NLEJ243350848 | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rakwb | ||
| 100 | 1 | |a SCHUESSLER, RICHARD B. |c Ph.D. |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a Abnormal Sinus Node Function in Clinical Arrhythmias |
| 264 | 1 | |a 350 Main Street , Malden , MA 02148 , USA , and 9600 Garsington Road , Oxford OX4 2DQ , UK . |b Blackwell Science Inc |c 2003 | |
| 300 | |a Online-Ressource | ||
| 336 | |a nicht spezifiziert |b zzz |2 rdacontent | ||
| 337 | |a nicht spezifiziert |b z |2 rdamedia | ||
| 338 | |a nicht spezifiziert |b zu |2 rdacarrier | ||
| 520 | |a Abnormal Sinus Node Function. To understand abnormal sinus node function in clinical atrial arrhythmias, it is essential to understand the normal function of the sinus node. Much of our understanding of the sinus node comes from work done in rabbits. In small animals, the node is a thin structure and can be modeled in two dimensions. However, in canines and humans, the node is a more complex structure completely surrounded by myocytes. Recent data suggest that the node may be insulated from the surrounding atrial myocytes, except at a limited number of exit sites. A model of the node with discrete exit sites explains how atrial activation can be initiated from multiple sites simultaneously. Within the node there may exist specialized pathways that explain the complex conduction within the node. Multiple cell types, with different intrinsic rates, combined with the nonuniform distribution of autonomic receptors, provide a basis for understanding the dynamics of heart rate control and the initiation of atrial activation. In addition, this model of the sinus node provides a framework to propose novel mechanisms underlying various atrial arrhythmias, such as atrial premature depolarizations or sinus node reentry. (J Cardiovasc Electrophysiol, Vol. 14, pp. 215-217, February 2003) | ||
| 533 | |d 2003 |f Blackwell Publishing Journal Backfiles 1879-2005 |7 |2003|||||||||| | ||
| 773 | 0 | 8 | |i In |t Journal of cardiovascular electrophysiology |d Oxford : Wiley-Blackwell, 1990 |g 14(2003), 2, Seite 0 |h Online-Ressource |w (DE-627)NLEJ243926243 |w (DE-600)2037519-0 |x 1540-8167 |7 nnns |
| 773 | 1 | 8 | |g volume:14 |g year:2003 |g number:2 |g pages:0 |
| 856 | 4 | 0 | |u http://dx.doi.org/10.1046/j.1540-8167.2003.02229.x |q text/html |x Verlag |z Deutschlandweit zugänglich |3 Volltext |
| 912 | |a GBV_USEFLAG_U | ||
| 912 | |a ZDB-1-DJB | ||
| 912 | |a GBV_NL_ARTICLE | ||
| 951 | |a AR | ||
| 952 | |d 14 |j 2003 |e 2 |h 0 | ||
| author_variant |
r b s rb rbs |
|---|---|
| matchkey_str |
article:15408167:2003----::bomliundfntoicii |
| hierarchy_sort_str |
2003 |
| publishDate |
2003 |
| allfields |
10.1046/j.1540-8167.2003.02229.x doi (DE-627)NLEJ243350848 DE-627 ger DE-627 rakwb SCHUESSLER, RICHARD B. Ph.D. verfasserin aut Abnormal Sinus Node Function in Clinical Arrhythmias 350 Main Street , Malden , MA 02148 , USA , and 9600 Garsington Road , Oxford OX4 2DQ , UK . Blackwell Science Inc 2003 Online-Ressource nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Abnormal Sinus Node Function. To understand abnormal sinus node function in clinical atrial arrhythmias, it is essential to understand the normal function of the sinus node. Much of our understanding of the sinus node comes from work done in rabbits. In small animals, the node is a thin structure and can be modeled in two dimensions. However, in canines and humans, the node is a more complex structure completely surrounded by myocytes. Recent data suggest that the node may be insulated from the surrounding atrial myocytes, except at a limited number of exit sites. A model of the node with discrete exit sites explains how atrial activation can be initiated from multiple sites simultaneously. Within the node there may exist specialized pathways that explain the complex conduction within the node. Multiple cell types, with different intrinsic rates, combined with the nonuniform distribution of autonomic receptors, provide a basis for understanding the dynamics of heart rate control and the initiation of atrial activation. In addition, this model of the sinus node provides a framework to propose novel mechanisms underlying various atrial arrhythmias, such as atrial premature depolarizations or sinus node reentry. (J Cardiovasc Electrophysiol, Vol. 14, pp. 215-217, February 2003) 2003 Blackwell Publishing Journal Backfiles 1879-2005 |2003|||||||||| In Journal of cardiovascular electrophysiology Oxford : Wiley-Blackwell, 1990 14(2003), 2, Seite 0 Online-Ressource (DE-627)NLEJ243926243 (DE-600)2037519-0 1540-8167 nnns volume:14 year:2003 number:2 pages:0 http://dx.doi.org/10.1046/j.1540-8167.2003.02229.x text/html Verlag Deutschlandweit zugänglich Volltext GBV_USEFLAG_U ZDB-1-DJB GBV_NL_ARTICLE AR 14 2003 2 0 |
| spelling |
10.1046/j.1540-8167.2003.02229.x doi (DE-627)NLEJ243350848 DE-627 ger DE-627 rakwb SCHUESSLER, RICHARD B. Ph.D. verfasserin aut Abnormal Sinus Node Function in Clinical Arrhythmias 350 Main Street , Malden , MA 02148 , USA , and 9600 Garsington Road , Oxford OX4 2DQ , UK . Blackwell Science Inc 2003 Online-Ressource nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Abnormal Sinus Node Function. To understand abnormal sinus node function in clinical atrial arrhythmias, it is essential to understand the normal function of the sinus node. Much of our understanding of the sinus node comes from work done in rabbits. In small animals, the node is a thin structure and can be modeled in two dimensions. However, in canines and humans, the node is a more complex structure completely surrounded by myocytes. Recent data suggest that the node may be insulated from the surrounding atrial myocytes, except at a limited number of exit sites. A model of the node with discrete exit sites explains how atrial activation can be initiated from multiple sites simultaneously. Within the node there may exist specialized pathways that explain the complex conduction within the node. Multiple cell types, with different intrinsic rates, combined with the nonuniform distribution of autonomic receptors, provide a basis for understanding the dynamics of heart rate control and the initiation of atrial activation. In addition, this model of the sinus node provides a framework to propose novel mechanisms underlying various atrial arrhythmias, such as atrial premature depolarizations or sinus node reentry. (J Cardiovasc Electrophysiol, Vol. 14, pp. 215-217, February 2003) 2003 Blackwell Publishing Journal Backfiles 1879-2005 |2003|||||||||| In Journal of cardiovascular electrophysiology Oxford : Wiley-Blackwell, 1990 14(2003), 2, Seite 0 Online-Ressource (DE-627)NLEJ243926243 (DE-600)2037519-0 1540-8167 nnns volume:14 year:2003 number:2 pages:0 http://dx.doi.org/10.1046/j.1540-8167.2003.02229.x text/html Verlag Deutschlandweit zugänglich Volltext GBV_USEFLAG_U ZDB-1-DJB GBV_NL_ARTICLE AR 14 2003 2 0 |
| allfields_unstemmed |
10.1046/j.1540-8167.2003.02229.x doi (DE-627)NLEJ243350848 DE-627 ger DE-627 rakwb SCHUESSLER, RICHARD B. Ph.D. verfasserin aut Abnormal Sinus Node Function in Clinical Arrhythmias 350 Main Street , Malden , MA 02148 , USA , and 9600 Garsington Road , Oxford OX4 2DQ , UK . Blackwell Science Inc 2003 Online-Ressource nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Abnormal Sinus Node Function. To understand abnormal sinus node function in clinical atrial arrhythmias, it is essential to understand the normal function of the sinus node. Much of our understanding of the sinus node comes from work done in rabbits. In small animals, the node is a thin structure and can be modeled in two dimensions. However, in canines and humans, the node is a more complex structure completely surrounded by myocytes. Recent data suggest that the node may be insulated from the surrounding atrial myocytes, except at a limited number of exit sites. A model of the node with discrete exit sites explains how atrial activation can be initiated from multiple sites simultaneously. Within the node there may exist specialized pathways that explain the complex conduction within the node. Multiple cell types, with different intrinsic rates, combined with the nonuniform distribution of autonomic receptors, provide a basis for understanding the dynamics of heart rate control and the initiation of atrial activation. In addition, this model of the sinus node provides a framework to propose novel mechanisms underlying various atrial arrhythmias, such as atrial premature depolarizations or sinus node reentry. (J Cardiovasc Electrophysiol, Vol. 14, pp. 215-217, February 2003) 2003 Blackwell Publishing Journal Backfiles 1879-2005 |2003|||||||||| In Journal of cardiovascular electrophysiology Oxford : Wiley-Blackwell, 1990 14(2003), 2, Seite 0 Online-Ressource (DE-627)NLEJ243926243 (DE-600)2037519-0 1540-8167 nnns volume:14 year:2003 number:2 pages:0 http://dx.doi.org/10.1046/j.1540-8167.2003.02229.x text/html Verlag Deutschlandweit zugänglich Volltext GBV_USEFLAG_U ZDB-1-DJB GBV_NL_ARTICLE AR 14 2003 2 0 |
| allfieldsGer |
10.1046/j.1540-8167.2003.02229.x doi (DE-627)NLEJ243350848 DE-627 ger DE-627 rakwb SCHUESSLER, RICHARD B. Ph.D. verfasserin aut Abnormal Sinus Node Function in Clinical Arrhythmias 350 Main Street , Malden , MA 02148 , USA , and 9600 Garsington Road , Oxford OX4 2DQ , UK . Blackwell Science Inc 2003 Online-Ressource nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Abnormal Sinus Node Function. To understand abnormal sinus node function in clinical atrial arrhythmias, it is essential to understand the normal function of the sinus node. Much of our understanding of the sinus node comes from work done in rabbits. In small animals, the node is a thin structure and can be modeled in two dimensions. However, in canines and humans, the node is a more complex structure completely surrounded by myocytes. Recent data suggest that the node may be insulated from the surrounding atrial myocytes, except at a limited number of exit sites. A model of the node with discrete exit sites explains how atrial activation can be initiated from multiple sites simultaneously. Within the node there may exist specialized pathways that explain the complex conduction within the node. Multiple cell types, with different intrinsic rates, combined with the nonuniform distribution of autonomic receptors, provide a basis for understanding the dynamics of heart rate control and the initiation of atrial activation. In addition, this model of the sinus node provides a framework to propose novel mechanisms underlying various atrial arrhythmias, such as atrial premature depolarizations or sinus node reentry. (J Cardiovasc Electrophysiol, Vol. 14, pp. 215-217, February 2003) 2003 Blackwell Publishing Journal Backfiles 1879-2005 |2003|||||||||| In Journal of cardiovascular electrophysiology Oxford : Wiley-Blackwell, 1990 14(2003), 2, Seite 0 Online-Ressource (DE-627)NLEJ243926243 (DE-600)2037519-0 1540-8167 nnns volume:14 year:2003 number:2 pages:0 http://dx.doi.org/10.1046/j.1540-8167.2003.02229.x text/html Verlag Deutschlandweit zugänglich Volltext GBV_USEFLAG_U ZDB-1-DJB GBV_NL_ARTICLE AR 14 2003 2 0 |
| allfieldsSound |
10.1046/j.1540-8167.2003.02229.x doi (DE-627)NLEJ243350848 DE-627 ger DE-627 rakwb SCHUESSLER, RICHARD B. Ph.D. verfasserin aut Abnormal Sinus Node Function in Clinical Arrhythmias 350 Main Street , Malden , MA 02148 , USA , and 9600 Garsington Road , Oxford OX4 2DQ , UK . Blackwell Science Inc 2003 Online-Ressource nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Abnormal Sinus Node Function. To understand abnormal sinus node function in clinical atrial arrhythmias, it is essential to understand the normal function of the sinus node. Much of our understanding of the sinus node comes from work done in rabbits. In small animals, the node is a thin structure and can be modeled in two dimensions. However, in canines and humans, the node is a more complex structure completely surrounded by myocytes. Recent data suggest that the node may be insulated from the surrounding atrial myocytes, except at a limited number of exit sites. A model of the node with discrete exit sites explains how atrial activation can be initiated from multiple sites simultaneously. Within the node there may exist specialized pathways that explain the complex conduction within the node. Multiple cell types, with different intrinsic rates, combined with the nonuniform distribution of autonomic receptors, provide a basis for understanding the dynamics of heart rate control and the initiation of atrial activation. In addition, this model of the sinus node provides a framework to propose novel mechanisms underlying various atrial arrhythmias, such as atrial premature depolarizations or sinus node reentry. (J Cardiovasc Electrophysiol, Vol. 14, pp. 215-217, February 2003) 2003 Blackwell Publishing Journal Backfiles 1879-2005 |2003|||||||||| In Journal of cardiovascular electrophysiology Oxford : Wiley-Blackwell, 1990 14(2003), 2, Seite 0 Online-Ressource (DE-627)NLEJ243926243 (DE-600)2037519-0 1540-8167 nnns volume:14 year:2003 number:2 pages:0 http://dx.doi.org/10.1046/j.1540-8167.2003.02229.x text/html Verlag Deutschlandweit zugänglich Volltext GBV_USEFLAG_U ZDB-1-DJB GBV_NL_ARTICLE AR 14 2003 2 0 |
| source |
In Journal of cardiovascular electrophysiology 14(2003), 2, Seite 0 volume:14 year:2003 number:2 pages:0 |
| sourceStr |
In Journal of cardiovascular electrophysiology 14(2003), 2, Seite 0 volume:14 year:2003 number:2 pages:0 |
| format_phy_str_mv |
Article |
| institution |
findex.gbv.de |
| isfreeaccess_bool |
false |
| container_title |
Journal of cardiovascular electrophysiology |
| authorswithroles_txt_mv |
SCHUESSLER, RICHARD B. @@aut@@ |
| publishDateDaySort_date |
2003-01-01T00:00:00Z |
| hierarchy_top_id |
NLEJ243926243 |
| id |
NLEJ243350848 |
| fullrecord |
<?xml version="1.0" encoding="UTF-8"?><collection xmlns="http://www.loc.gov/MARC21/slim"><record><leader>01000caa a22002652 4500</leader><controlfield tag="001">NLEJ243350848</controlfield><controlfield tag="003">DE-627</controlfield><controlfield tag="005">20210707175922.0</controlfield><controlfield tag="007">cr uuu---uuuuu</controlfield><controlfield tag="008">120427s2003 xx |||||o 00| ||und c</controlfield><datafield tag="024" ind1="7" ind2=" "><subfield code="a">10.1046/j.1540-8167.2003.02229.x</subfield><subfield code="2">doi</subfield></datafield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(DE-627)NLEJ243350848</subfield></datafield><datafield tag="040" ind1=" " ind2=" "><subfield code="a">DE-627</subfield><subfield code="b">ger</subfield><subfield code="c">DE-627</subfield><subfield code="e">rakwb</subfield></datafield><datafield tag="100" ind1="1" ind2=" "><subfield code="a">SCHUESSLER, RICHARD B.</subfield><subfield code="c">Ph.D.</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="245" ind1="1" ind2="0"><subfield code="a">Abnormal Sinus Node Function in Clinical Arrhythmias</subfield></datafield><datafield tag="264" ind1=" " ind2="1"><subfield code="a">350 Main Street , Malden , MA 02148 , USA , and 9600 Garsington Road , Oxford OX4 2DQ , UK .</subfield><subfield code="b">Blackwell Science Inc</subfield><subfield code="c">2003</subfield></datafield><datafield tag="300" ind1=" " ind2=" "><subfield code="a">Online-Ressource</subfield></datafield><datafield tag="336" ind1=" " ind2=" "><subfield code="a">nicht spezifiziert</subfield><subfield code="b">zzz</subfield><subfield code="2">rdacontent</subfield></datafield><datafield tag="337" ind1=" " ind2=" "><subfield code="a">nicht spezifiziert</subfield><subfield code="b">z</subfield><subfield code="2">rdamedia</subfield></datafield><datafield tag="338" ind1=" " ind2=" "><subfield code="a">nicht spezifiziert</subfield><subfield code="b">zu</subfield><subfield code="2">rdacarrier</subfield></datafield><datafield tag="520" ind1=" " ind2=" "><subfield code="a">Abnormal Sinus Node Function. To understand abnormal sinus node function in clinical atrial arrhythmias, it is essential to understand the normal function of the sinus node. Much of our understanding of the sinus node comes from work done in rabbits. In small animals, the node is a thin structure and can be modeled in two dimensions. However, in canines and humans, the node is a more complex structure completely surrounded by myocytes. Recent data suggest that the node may be insulated from the surrounding atrial myocytes, except at a limited number of exit sites. A model of the node with discrete exit sites explains how atrial activation can be initiated from multiple sites simultaneously. Within the node there may exist specialized pathways that explain the complex conduction within the node. Multiple cell types, with different intrinsic rates, combined with the nonuniform distribution of autonomic receptors, provide a basis for understanding the dynamics of heart rate control and the initiation of atrial activation. In addition, this model of the sinus node provides a framework to propose novel mechanisms underlying various atrial arrhythmias, such as atrial premature depolarizations or sinus node reentry. (J Cardiovasc Electrophysiol, Vol. 14, pp. 215-217, February 2003)</subfield></datafield><datafield tag="533" ind1=" " ind2=" "><subfield code="d">2003</subfield><subfield code="f">Blackwell Publishing Journal Backfiles 1879-2005</subfield><subfield code="7">|2003||||||||||</subfield></datafield><datafield tag="773" ind1="0" ind2="8"><subfield code="i">In</subfield><subfield code="t">Journal of cardiovascular electrophysiology</subfield><subfield code="d">Oxford : Wiley-Blackwell, 1990</subfield><subfield code="g">14(2003), 2, Seite 0</subfield><subfield code="h">Online-Ressource</subfield><subfield code="w">(DE-627)NLEJ243926243</subfield><subfield code="w">(DE-600)2037519-0</subfield><subfield code="x">1540-8167</subfield><subfield code="7">nnns</subfield></datafield><datafield tag="773" ind1="1" ind2="8"><subfield code="g">volume:14</subfield><subfield code="g">year:2003</subfield><subfield code="g">number:2</subfield><subfield code="g">pages:0</subfield></datafield><datafield tag="856" ind1="4" ind2="0"><subfield code="u">http://dx.doi.org/10.1046/j.1540-8167.2003.02229.x</subfield><subfield code="q">text/html</subfield><subfield code="x">Verlag</subfield><subfield code="z">Deutschlandweit zugänglich</subfield><subfield code="3">Volltext</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_USEFLAG_U</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">ZDB-1-DJB</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_NL_ARTICLE</subfield></datafield><datafield tag="951" ind1=" " ind2=" "><subfield code="a">AR</subfield></datafield><datafield tag="952" ind1=" " ind2=" "><subfield code="d">14</subfield><subfield code="j">2003</subfield><subfield code="e">2</subfield><subfield code="h">0</subfield></datafield></record></collection>
|
| series2 |
Blackwell Publishing Journal Backfiles 1879-2005 |
| author |
SCHUESSLER, RICHARD B. Ph.D. |
| spellingShingle |
SCHUESSLER, RICHARD B. Ph.D. Abnormal Sinus Node Function in Clinical Arrhythmias |
| authorStr |
SCHUESSLER, RICHARD B. Ph.D. |
| ppnlink_with_tag_str_mv |
@@773@@(DE-627)NLEJ243926243 |
| format |
electronic Article |
| delete_txt_mv |
keep |
| author_role |
aut |
| collection |
NL |
| publishPlace |
350 Main Street , Malden , MA 02148 , USA , and 9600 Garsington Road , Oxford OX4 2DQ , UK . |
| remote_str |
true |
| illustrated |
Not Illustrated |
| issn |
1540-8167 |
| topic_title |
Abnormal Sinus Node Function in Clinical Arrhythmias |
| publisher |
Blackwell Science Inc |
| publisherStr |
Blackwell Science Inc |
| format_facet |
Elektronische Aufsätze Aufsätze Elektronische Ressource |
| format_main_str_mv |
Text Zeitschrift/Artikel |
| carriertype_str_mv |
zu |
| hierarchy_parent_title |
Journal of cardiovascular electrophysiology |
| hierarchy_parent_id |
NLEJ243926243 |
| hierarchy_top_title |
Journal of cardiovascular electrophysiology |
| isfreeaccess_txt |
false |
| familylinks_str_mv |
(DE-627)NLEJ243926243 (DE-600)2037519-0 |
| title |
Abnormal Sinus Node Function in Clinical Arrhythmias |
| ctrlnum |
(DE-627)NLEJ243350848 |
| title_full |
Abnormal Sinus Node Function in Clinical Arrhythmias |
| author_sort |
SCHUESSLER, RICHARD B. Ph.D. |
| journal |
Journal of cardiovascular electrophysiology |
| journalStr |
Journal of cardiovascular electrophysiology |
| isOA_bool |
false |
| recordtype |
marc |
| publishDateSort |
2003 |
| contenttype_str_mv |
zzz |
| container_start_page |
0 |
| author_browse |
SCHUESSLER, RICHARD B. |
| container_volume |
14 |
| physical |
Online-Ressource |
| format_se |
Elektronische Aufsätze |
| author-letter |
SCHUESSLER, RICHARD B. |
| doi_str_mv |
10.1046/j.1540-8167.2003.02229.x |
| title_sort |
abnormal sinus node function in clinical arrhythmias |
| title_auth |
Abnormal Sinus Node Function in Clinical Arrhythmias |
| abstract |
Abnormal Sinus Node Function. To understand abnormal sinus node function in clinical atrial arrhythmias, it is essential to understand the normal function of the sinus node. Much of our understanding of the sinus node comes from work done in rabbits. In small animals, the node is a thin structure and can be modeled in two dimensions. However, in canines and humans, the node is a more complex structure completely surrounded by myocytes. Recent data suggest that the node may be insulated from the surrounding atrial myocytes, except at a limited number of exit sites. A model of the node with discrete exit sites explains how atrial activation can be initiated from multiple sites simultaneously. Within the node there may exist specialized pathways that explain the complex conduction within the node. Multiple cell types, with different intrinsic rates, combined with the nonuniform distribution of autonomic receptors, provide a basis for understanding the dynamics of heart rate control and the initiation of atrial activation. In addition, this model of the sinus node provides a framework to propose novel mechanisms underlying various atrial arrhythmias, such as atrial premature depolarizations or sinus node reentry. (J Cardiovasc Electrophysiol, Vol. 14, pp. 215-217, February 2003) |
| abstractGer |
Abnormal Sinus Node Function. To understand abnormal sinus node function in clinical atrial arrhythmias, it is essential to understand the normal function of the sinus node. Much of our understanding of the sinus node comes from work done in rabbits. In small animals, the node is a thin structure and can be modeled in two dimensions. However, in canines and humans, the node is a more complex structure completely surrounded by myocytes. Recent data suggest that the node may be insulated from the surrounding atrial myocytes, except at a limited number of exit sites. A model of the node with discrete exit sites explains how atrial activation can be initiated from multiple sites simultaneously. Within the node there may exist specialized pathways that explain the complex conduction within the node. Multiple cell types, with different intrinsic rates, combined with the nonuniform distribution of autonomic receptors, provide a basis for understanding the dynamics of heart rate control and the initiation of atrial activation. In addition, this model of the sinus node provides a framework to propose novel mechanisms underlying various atrial arrhythmias, such as atrial premature depolarizations or sinus node reentry. (J Cardiovasc Electrophysiol, Vol. 14, pp. 215-217, February 2003) |
| abstract_unstemmed |
Abnormal Sinus Node Function. To understand abnormal sinus node function in clinical atrial arrhythmias, it is essential to understand the normal function of the sinus node. Much of our understanding of the sinus node comes from work done in rabbits. In small animals, the node is a thin structure and can be modeled in two dimensions. However, in canines and humans, the node is a more complex structure completely surrounded by myocytes. Recent data suggest that the node may be insulated from the surrounding atrial myocytes, except at a limited number of exit sites. A model of the node with discrete exit sites explains how atrial activation can be initiated from multiple sites simultaneously. Within the node there may exist specialized pathways that explain the complex conduction within the node. Multiple cell types, with different intrinsic rates, combined with the nonuniform distribution of autonomic receptors, provide a basis for understanding the dynamics of heart rate control and the initiation of atrial activation. In addition, this model of the sinus node provides a framework to propose novel mechanisms underlying various atrial arrhythmias, such as atrial premature depolarizations or sinus node reentry. (J Cardiovasc Electrophysiol, Vol. 14, pp. 215-217, February 2003) |
| collection_details |
GBV_USEFLAG_U ZDB-1-DJB GBV_NL_ARTICLE |
| container_issue |
2 |
| title_short |
Abnormal Sinus Node Function in Clinical Arrhythmias |
| url |
http://dx.doi.org/10.1046/j.1540-8167.2003.02229.x |
| remote_bool |
true |
| ppnlink |
NLEJ243926243 |
| mediatype_str_mv |
z |
| isOA_txt |
false |
| hochschulschrift_bool |
false |
| doi_str |
10.1046/j.1540-8167.2003.02229.x |
| up_date |
2024-07-06T05:10:54.695Z |
| _version_ |
1803805161888415744 |
| fullrecord_marcxml |
<?xml version="1.0" encoding="UTF-8"?><collection xmlns="http://www.loc.gov/MARC21/slim"><record><leader>01000caa a22002652 4500</leader><controlfield tag="001">NLEJ243350848</controlfield><controlfield tag="003">DE-627</controlfield><controlfield tag="005">20210707175922.0</controlfield><controlfield tag="007">cr uuu---uuuuu</controlfield><controlfield tag="008">120427s2003 xx |||||o 00| ||und c</controlfield><datafield tag="024" ind1="7" ind2=" "><subfield code="a">10.1046/j.1540-8167.2003.02229.x</subfield><subfield code="2">doi</subfield></datafield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(DE-627)NLEJ243350848</subfield></datafield><datafield tag="040" ind1=" " ind2=" "><subfield code="a">DE-627</subfield><subfield code="b">ger</subfield><subfield code="c">DE-627</subfield><subfield code="e">rakwb</subfield></datafield><datafield tag="100" ind1="1" ind2=" "><subfield code="a">SCHUESSLER, RICHARD B.</subfield><subfield code="c">Ph.D.</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="245" ind1="1" ind2="0"><subfield code="a">Abnormal Sinus Node Function in Clinical Arrhythmias</subfield></datafield><datafield tag="264" ind1=" " ind2="1"><subfield code="a">350 Main Street , Malden , MA 02148 , USA , and 9600 Garsington Road , Oxford OX4 2DQ , UK .</subfield><subfield code="b">Blackwell Science Inc</subfield><subfield code="c">2003</subfield></datafield><datafield tag="300" ind1=" " ind2=" "><subfield code="a">Online-Ressource</subfield></datafield><datafield tag="336" ind1=" " ind2=" "><subfield code="a">nicht spezifiziert</subfield><subfield code="b">zzz</subfield><subfield code="2">rdacontent</subfield></datafield><datafield tag="337" ind1=" " ind2=" "><subfield code="a">nicht spezifiziert</subfield><subfield code="b">z</subfield><subfield code="2">rdamedia</subfield></datafield><datafield tag="338" ind1=" " ind2=" "><subfield code="a">nicht spezifiziert</subfield><subfield code="b">zu</subfield><subfield code="2">rdacarrier</subfield></datafield><datafield tag="520" ind1=" " ind2=" "><subfield code="a">Abnormal Sinus Node Function. To understand abnormal sinus node function in clinical atrial arrhythmias, it is essential to understand the normal function of the sinus node. Much of our understanding of the sinus node comes from work done in rabbits. In small animals, the node is a thin structure and can be modeled in two dimensions. However, in canines and humans, the node is a more complex structure completely surrounded by myocytes. Recent data suggest that the node may be insulated from the surrounding atrial myocytes, except at a limited number of exit sites. A model of the node with discrete exit sites explains how atrial activation can be initiated from multiple sites simultaneously. Within the node there may exist specialized pathways that explain the complex conduction within the node. Multiple cell types, with different intrinsic rates, combined with the nonuniform distribution of autonomic receptors, provide a basis for understanding the dynamics of heart rate control and the initiation of atrial activation. In addition, this model of the sinus node provides a framework to propose novel mechanisms underlying various atrial arrhythmias, such as atrial premature depolarizations or sinus node reentry. (J Cardiovasc Electrophysiol, Vol. 14, pp. 215-217, February 2003)</subfield></datafield><datafield tag="533" ind1=" " ind2=" "><subfield code="d">2003</subfield><subfield code="f">Blackwell Publishing Journal Backfiles 1879-2005</subfield><subfield code="7">|2003||||||||||</subfield></datafield><datafield tag="773" ind1="0" ind2="8"><subfield code="i">In</subfield><subfield code="t">Journal of cardiovascular electrophysiology</subfield><subfield code="d">Oxford : Wiley-Blackwell, 1990</subfield><subfield code="g">14(2003), 2, Seite 0</subfield><subfield code="h">Online-Ressource</subfield><subfield code="w">(DE-627)NLEJ243926243</subfield><subfield code="w">(DE-600)2037519-0</subfield><subfield code="x">1540-8167</subfield><subfield code="7">nnns</subfield></datafield><datafield tag="773" ind1="1" ind2="8"><subfield code="g">volume:14</subfield><subfield code="g">year:2003</subfield><subfield code="g">number:2</subfield><subfield code="g">pages:0</subfield></datafield><datafield tag="856" ind1="4" ind2="0"><subfield code="u">http://dx.doi.org/10.1046/j.1540-8167.2003.02229.x</subfield><subfield code="q">text/html</subfield><subfield code="x">Verlag</subfield><subfield code="z">Deutschlandweit zugänglich</subfield><subfield code="3">Volltext</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_USEFLAG_U</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">ZDB-1-DJB</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_NL_ARTICLE</subfield></datafield><datafield tag="951" ind1=" " ind2=" "><subfield code="a">AR</subfield></datafield><datafield tag="952" ind1=" " ind2=" "><subfield code="d">14</subfield><subfield code="j">2003</subfield><subfield code="e">2</subfield><subfield code="h">0</subfield></datafield></record></collection>
|
| score |
7.3994074 |