Existence of Bistability and Correlation with Arrhythmogenesis in Paced Sheep Atria
Bistability and Arrhythmogenesis in Paced Sheep Atria. Introduction: Studies of the electrical dynamics of cardiac tissue are important for understanding the mechanisms of arrhythmias. This study uses high-frequency pacing to investigate the dynamics of sheep atria. Methods and Results: A 504-electr...
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| Autor*in: |
OLIVER, ROBERT A. - M.S. [verfasserIn] HALL, G. MARTIN - Ph.D. [verfasserIn] BAHAR, SONYA - Ph.D. [verfasserIn] KRASSOWSKA, WANDA - Ph.D. WOLF, PATRICK D. - Ph.D. TULLOCH, ELLEN G. DIXON - M.S. GAUTHIER, DANIEL J. - Ph.D. |
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E-Artikel |
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| Erschienen: |
Oxford, UK: Blackwell Publishing Ltd ; 2000 |
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Online-Ressource |
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| Reproduktion: |
2007 ; Blackwell Publishing Journal Backfiles 1879-2005 |
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In: Journal of cardiovascular electrophysiology - Oxford : Wiley-Blackwell, 1990, 11(2000), 7, Seite 0 |
| Übergeordnetes Werk: |
volume:11 ; year:2000 ; number:7 ; pages:0 |
| Links: |
|---|
| DOI / URN: |
10.1111/j.1540-8167.2000.tb00051.x |
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NLEJ24335858X |
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| 245 | 1 | 0 | |a Existence of Bistability and Correlation with Arrhythmogenesis in Paced Sheep Atria |
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| 520 | |a Bistability and Arrhythmogenesis in Paced Sheep Atria. Introduction: Studies of the electrical dynamics of cardiac tissue are important for understanding the mechanisms of arrhythmias. This study uses high-frequency pacing to investigate the dynamics of sheep atria. Methods and Results: A 504-electrode mapping plaque was affixed to the right atrium in six sheep. Cathodal pacing stimuli were delivered to the center of the plaque. Pacing period (Tp) was decreased from 275 ± 25 msec to 75 ± 25 msec and then increased to 230 ± 70 msec in steps of either 5 or 10 msec. In all 21 trials in six sheep, the atrium responded 1:1 at longer Tps and 2:1 at shorter Tps. As Tp was decreased, the response switched to 2:1 at a particular Tp. Conversely, as Tp was increased, the response switched back to 1:1 at a particular Tp. Over 21 trials, the l:1-to-2:l and 2:l-to-l:l transitions occurred at 119.5 ± 18.8 msec and 130.0 ± 19.1 m.sec, respectively. This hysteretic behavior yielded bistability windows. 10.5 ± 7.2 msec wide, wherein 1:1 and 2:1 responses existed at the same Tp. In 15 trials and in all animals, idiopathic wavefronts emanating from outside the mapped region passed through the mapped region. In 13 of those trials, the idiopathic wavefronts occurred at Tps within the bistability window or within 35 msec of its upper or lower limit. Conclusion: Bistability windows and idiopathic wavefronts were observed and found to be correlated with each other, suggesting a connection between bistability and arrhythmogenesis. | ||
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| 700 | 1 | |a TULLOCH, ELLEN G. DIXON |c M.S. |4 oth | |
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10.1111/j.1540-8167.2000.tb00051.x doi (DE-627)NLEJ24335858X DE-627 ger DE-627 rakwb OLIVER, ROBERT A. M.S. verfasserin aut Existence of Bistability and Correlation with Arrhythmogenesis in Paced Sheep Atria Oxford, UK Blackwell Publishing Ltd 2000 Online-Ressource nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Bistability and Arrhythmogenesis in Paced Sheep Atria. Introduction: Studies of the electrical dynamics of cardiac tissue are important for understanding the mechanisms of arrhythmias. This study uses high-frequency pacing to investigate the dynamics of sheep atria. Methods and Results: A 504-electrode mapping plaque was affixed to the right atrium in six sheep. Cathodal pacing stimuli were delivered to the center of the plaque. Pacing period (Tp) was decreased from 275 ± 25 msec to 75 ± 25 msec and then increased to 230 ± 70 msec in steps of either 5 or 10 msec. In all 21 trials in six sheep, the atrium responded 1:1 at longer Tps and 2:1 at shorter Tps. As Tp was decreased, the response switched to 2:1 at a particular Tp. Conversely, as Tp was increased, the response switched back to 1:1 at a particular Tp. Over 21 trials, the l:1-to-2:l and 2:l-to-l:l transitions occurred at 119.5 ± 18.8 msec and 130.0 ± 19.1 m.sec, respectively. This hysteretic behavior yielded bistability windows. 10.5 ± 7.2 msec wide, wherein 1:1 and 2:1 responses existed at the same Tp. In 15 trials and in all animals, idiopathic wavefronts emanating from outside the mapped region passed through the mapped region. In 13 of those trials, the idiopathic wavefronts occurred at Tps within the bistability window or within 35 msec of its upper or lower limit. Conclusion: Bistability windows and idiopathic wavefronts were observed and found to be correlated with each other, suggesting a connection between bistability and arrhythmogenesis. 2007 Blackwell Publishing Journal Backfiles 1879-2005 |2007|||||||||| bistability HALL, G. MARTIN Ph.D. verfasserin aut BAHAR, SONYA Ph.D. verfasserin aut KRASSOWSKA, WANDA Ph.D. oth WOLF, PATRICK D. Ph.D. oth TULLOCH, ELLEN G. DIXON M.S. oth GAUTHIER, DANIEL J. Ph.D. oth In Journal of cardiovascular electrophysiology Oxford : Wiley-Blackwell, 1990 11(2000), 7, Seite 0 Online-Ressource (DE-627)NLEJ243926243 (DE-600)2037519-0 1540-8167 nnns volume:11 year:2000 number:7 pages:0 http://dx.doi.org/10.1111/j.1540-8167.2000.tb00051.x text/html Verlag Deutschlandweit zugänglich Volltext GBV_USEFLAG_U ZDB-1-DJB GBV_NL_ARTICLE AR 11 2000 7 0 |
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10.1111/j.1540-8167.2000.tb00051.x doi (DE-627)NLEJ24335858X DE-627 ger DE-627 rakwb OLIVER, ROBERT A. M.S. verfasserin aut Existence of Bistability and Correlation with Arrhythmogenesis in Paced Sheep Atria Oxford, UK Blackwell Publishing Ltd 2000 Online-Ressource nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Bistability and Arrhythmogenesis in Paced Sheep Atria. Introduction: Studies of the electrical dynamics of cardiac tissue are important for understanding the mechanisms of arrhythmias. This study uses high-frequency pacing to investigate the dynamics of sheep atria. Methods and Results: A 504-electrode mapping plaque was affixed to the right atrium in six sheep. Cathodal pacing stimuli were delivered to the center of the plaque. Pacing period (Tp) was decreased from 275 ± 25 msec to 75 ± 25 msec and then increased to 230 ± 70 msec in steps of either 5 or 10 msec. In all 21 trials in six sheep, the atrium responded 1:1 at longer Tps and 2:1 at shorter Tps. As Tp was decreased, the response switched to 2:1 at a particular Tp. Conversely, as Tp was increased, the response switched back to 1:1 at a particular Tp. Over 21 trials, the l:1-to-2:l and 2:l-to-l:l transitions occurred at 119.5 ± 18.8 msec and 130.0 ± 19.1 m.sec, respectively. This hysteretic behavior yielded bistability windows. 10.5 ± 7.2 msec wide, wherein 1:1 and 2:1 responses existed at the same Tp. In 15 trials and in all animals, idiopathic wavefronts emanating from outside the mapped region passed through the mapped region. In 13 of those trials, the idiopathic wavefronts occurred at Tps within the bistability window or within 35 msec of its upper or lower limit. Conclusion: Bistability windows and idiopathic wavefronts were observed and found to be correlated with each other, suggesting a connection between bistability and arrhythmogenesis. 2007 Blackwell Publishing Journal Backfiles 1879-2005 |2007|||||||||| bistability HALL, G. MARTIN Ph.D. verfasserin aut BAHAR, SONYA Ph.D. verfasserin aut KRASSOWSKA, WANDA Ph.D. oth WOLF, PATRICK D. Ph.D. oth TULLOCH, ELLEN G. DIXON M.S. oth GAUTHIER, DANIEL J. Ph.D. oth In Journal of cardiovascular electrophysiology Oxford : Wiley-Blackwell, 1990 11(2000), 7, Seite 0 Online-Ressource (DE-627)NLEJ243926243 (DE-600)2037519-0 1540-8167 nnns volume:11 year:2000 number:7 pages:0 http://dx.doi.org/10.1111/j.1540-8167.2000.tb00051.x text/html Verlag Deutschlandweit zugänglich Volltext GBV_USEFLAG_U ZDB-1-DJB GBV_NL_ARTICLE AR 11 2000 7 0 |
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10.1111/j.1540-8167.2000.tb00051.x doi (DE-627)NLEJ24335858X DE-627 ger DE-627 rakwb OLIVER, ROBERT A. M.S. verfasserin aut Existence of Bistability and Correlation with Arrhythmogenesis in Paced Sheep Atria Oxford, UK Blackwell Publishing Ltd 2000 Online-Ressource nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Bistability and Arrhythmogenesis in Paced Sheep Atria. Introduction: Studies of the electrical dynamics of cardiac tissue are important for understanding the mechanisms of arrhythmias. This study uses high-frequency pacing to investigate the dynamics of sheep atria. Methods and Results: A 504-electrode mapping plaque was affixed to the right atrium in six sheep. Cathodal pacing stimuli were delivered to the center of the plaque. Pacing period (Tp) was decreased from 275 ± 25 msec to 75 ± 25 msec and then increased to 230 ± 70 msec in steps of either 5 or 10 msec. In all 21 trials in six sheep, the atrium responded 1:1 at longer Tps and 2:1 at shorter Tps. As Tp was decreased, the response switched to 2:1 at a particular Tp. Conversely, as Tp was increased, the response switched back to 1:1 at a particular Tp. Over 21 trials, the l:1-to-2:l and 2:l-to-l:l transitions occurred at 119.5 ± 18.8 msec and 130.0 ± 19.1 m.sec, respectively. This hysteretic behavior yielded bistability windows. 10.5 ± 7.2 msec wide, wherein 1:1 and 2:1 responses existed at the same Tp. In 15 trials and in all animals, idiopathic wavefronts emanating from outside the mapped region passed through the mapped region. In 13 of those trials, the idiopathic wavefronts occurred at Tps within the bistability window or within 35 msec of its upper or lower limit. Conclusion: Bistability windows and idiopathic wavefronts were observed and found to be correlated with each other, suggesting a connection between bistability and arrhythmogenesis. 2007 Blackwell Publishing Journal Backfiles 1879-2005 |2007|||||||||| bistability HALL, G. MARTIN Ph.D. verfasserin aut BAHAR, SONYA Ph.D. verfasserin aut KRASSOWSKA, WANDA Ph.D. oth WOLF, PATRICK D. Ph.D. oth TULLOCH, ELLEN G. DIXON M.S. oth GAUTHIER, DANIEL J. Ph.D. oth In Journal of cardiovascular electrophysiology Oxford : Wiley-Blackwell, 1990 11(2000), 7, Seite 0 Online-Ressource (DE-627)NLEJ243926243 (DE-600)2037519-0 1540-8167 nnns volume:11 year:2000 number:7 pages:0 http://dx.doi.org/10.1111/j.1540-8167.2000.tb00051.x text/html Verlag Deutschlandweit zugänglich Volltext GBV_USEFLAG_U ZDB-1-DJB GBV_NL_ARTICLE AR 11 2000 7 0 |
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10.1111/j.1540-8167.2000.tb00051.x doi (DE-627)NLEJ24335858X DE-627 ger DE-627 rakwb OLIVER, ROBERT A. M.S. verfasserin aut Existence of Bistability and Correlation with Arrhythmogenesis in Paced Sheep Atria Oxford, UK Blackwell Publishing Ltd 2000 Online-Ressource nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Bistability and Arrhythmogenesis in Paced Sheep Atria. Introduction: Studies of the electrical dynamics of cardiac tissue are important for understanding the mechanisms of arrhythmias. This study uses high-frequency pacing to investigate the dynamics of sheep atria. Methods and Results: A 504-electrode mapping plaque was affixed to the right atrium in six sheep. Cathodal pacing stimuli were delivered to the center of the plaque. Pacing period (Tp) was decreased from 275 ± 25 msec to 75 ± 25 msec and then increased to 230 ± 70 msec in steps of either 5 or 10 msec. In all 21 trials in six sheep, the atrium responded 1:1 at longer Tps and 2:1 at shorter Tps. As Tp was decreased, the response switched to 2:1 at a particular Tp. Conversely, as Tp was increased, the response switched back to 1:1 at a particular Tp. Over 21 trials, the l:1-to-2:l and 2:l-to-l:l transitions occurred at 119.5 ± 18.8 msec and 130.0 ± 19.1 m.sec, respectively. This hysteretic behavior yielded bistability windows. 10.5 ± 7.2 msec wide, wherein 1:1 and 2:1 responses existed at the same Tp. In 15 trials and in all animals, idiopathic wavefronts emanating from outside the mapped region passed through the mapped region. In 13 of those trials, the idiopathic wavefronts occurred at Tps within the bistability window or within 35 msec of its upper or lower limit. Conclusion: Bistability windows and idiopathic wavefronts were observed and found to be correlated with each other, suggesting a connection between bistability and arrhythmogenesis. 2007 Blackwell Publishing Journal Backfiles 1879-2005 |2007|||||||||| bistability HALL, G. MARTIN Ph.D. verfasserin aut BAHAR, SONYA Ph.D. verfasserin aut KRASSOWSKA, WANDA Ph.D. oth WOLF, PATRICK D. Ph.D. oth TULLOCH, ELLEN G. DIXON M.S. oth GAUTHIER, DANIEL J. Ph.D. oth In Journal of cardiovascular electrophysiology Oxford : Wiley-Blackwell, 1990 11(2000), 7, Seite 0 Online-Ressource (DE-627)NLEJ243926243 (DE-600)2037519-0 1540-8167 nnns volume:11 year:2000 number:7 pages:0 http://dx.doi.org/10.1111/j.1540-8167.2000.tb00051.x text/html Verlag Deutschlandweit zugänglich Volltext GBV_USEFLAG_U ZDB-1-DJB GBV_NL_ARTICLE AR 11 2000 7 0 |
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10.1111/j.1540-8167.2000.tb00051.x doi (DE-627)NLEJ24335858X DE-627 ger DE-627 rakwb OLIVER, ROBERT A. M.S. verfasserin aut Existence of Bistability and Correlation with Arrhythmogenesis in Paced Sheep Atria Oxford, UK Blackwell Publishing Ltd 2000 Online-Ressource nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Bistability and Arrhythmogenesis in Paced Sheep Atria. Introduction: Studies of the electrical dynamics of cardiac tissue are important for understanding the mechanisms of arrhythmias. This study uses high-frequency pacing to investigate the dynamics of sheep atria. Methods and Results: A 504-electrode mapping plaque was affixed to the right atrium in six sheep. Cathodal pacing stimuli were delivered to the center of the plaque. Pacing period (Tp) was decreased from 275 ± 25 msec to 75 ± 25 msec and then increased to 230 ± 70 msec in steps of either 5 or 10 msec. In all 21 trials in six sheep, the atrium responded 1:1 at longer Tps and 2:1 at shorter Tps. As Tp was decreased, the response switched to 2:1 at a particular Tp. Conversely, as Tp was increased, the response switched back to 1:1 at a particular Tp. Over 21 trials, the l:1-to-2:l and 2:l-to-l:l transitions occurred at 119.5 ± 18.8 msec and 130.0 ± 19.1 m.sec, respectively. This hysteretic behavior yielded bistability windows. 10.5 ± 7.2 msec wide, wherein 1:1 and 2:1 responses existed at the same Tp. In 15 trials and in all animals, idiopathic wavefronts emanating from outside the mapped region passed through the mapped region. In 13 of those trials, the idiopathic wavefronts occurred at Tps within the bistability window or within 35 msec of its upper or lower limit. Conclusion: Bistability windows and idiopathic wavefronts were observed and found to be correlated with each other, suggesting a connection between bistability and arrhythmogenesis. 2007 Blackwell Publishing Journal Backfiles 1879-2005 |2007|||||||||| bistability HALL, G. MARTIN Ph.D. verfasserin aut BAHAR, SONYA Ph.D. verfasserin aut KRASSOWSKA, WANDA Ph.D. oth WOLF, PATRICK D. Ph.D. oth TULLOCH, ELLEN G. DIXON M.S. oth GAUTHIER, DANIEL J. Ph.D. oth In Journal of cardiovascular electrophysiology Oxford : Wiley-Blackwell, 1990 11(2000), 7, Seite 0 Online-Ressource (DE-627)NLEJ243926243 (DE-600)2037519-0 1540-8167 nnns volume:11 year:2000 number:7 pages:0 http://dx.doi.org/10.1111/j.1540-8167.2000.tb00051.x text/html Verlag Deutschlandweit zugänglich Volltext GBV_USEFLAG_U ZDB-1-DJB GBV_NL_ARTICLE AR 11 2000 7 0 |
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Blackwell Publishing Journal Backfiles 1879-2005 |
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OLIVER, ROBERT A. M.S. |
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OLIVER, ROBERT A. M.S. misc bistability Existence of Bistability and Correlation with Arrhythmogenesis in Paced Sheep Atria |
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Existence of Bistability and Correlation with Arrhythmogenesis in Paced Sheep Atria bistability |
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Existence of Bistability and Correlation with Arrhythmogenesis in Paced Sheep Atria |
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Existence of Bistability and Correlation with Arrhythmogenesis in Paced Sheep Atria |
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OLIVER, ROBERT A. M.S. |
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Journal of cardiovascular electrophysiology |
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OLIVER, ROBERT A. HALL, G. MARTIN BAHAR, SONYA |
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OLIVER, ROBERT A. |
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10.1111/j.1540-8167.2000.tb00051.x |
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existence of bistability and correlation with arrhythmogenesis in paced sheep atria |
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Existence of Bistability and Correlation with Arrhythmogenesis in Paced Sheep Atria |
| abstract |
Bistability and Arrhythmogenesis in Paced Sheep Atria. Introduction: Studies of the electrical dynamics of cardiac tissue are important for understanding the mechanisms of arrhythmias. This study uses high-frequency pacing to investigate the dynamics of sheep atria. Methods and Results: A 504-electrode mapping plaque was affixed to the right atrium in six sheep. Cathodal pacing stimuli were delivered to the center of the plaque. Pacing period (Tp) was decreased from 275 ± 25 msec to 75 ± 25 msec and then increased to 230 ± 70 msec in steps of either 5 or 10 msec. In all 21 trials in six sheep, the atrium responded 1:1 at longer Tps and 2:1 at shorter Tps. As Tp was decreased, the response switched to 2:1 at a particular Tp. Conversely, as Tp was increased, the response switched back to 1:1 at a particular Tp. Over 21 trials, the l:1-to-2:l and 2:l-to-l:l transitions occurred at 119.5 ± 18.8 msec and 130.0 ± 19.1 m.sec, respectively. This hysteretic behavior yielded bistability windows. 10.5 ± 7.2 msec wide, wherein 1:1 and 2:1 responses existed at the same Tp. In 15 trials and in all animals, idiopathic wavefronts emanating from outside the mapped region passed through the mapped region. In 13 of those trials, the idiopathic wavefronts occurred at Tps within the bistability window or within 35 msec of its upper or lower limit. Conclusion: Bistability windows and idiopathic wavefronts were observed and found to be correlated with each other, suggesting a connection between bistability and arrhythmogenesis. |
| abstractGer |
Bistability and Arrhythmogenesis in Paced Sheep Atria. Introduction: Studies of the electrical dynamics of cardiac tissue are important for understanding the mechanisms of arrhythmias. This study uses high-frequency pacing to investigate the dynamics of sheep atria. Methods and Results: A 504-electrode mapping plaque was affixed to the right atrium in six sheep. Cathodal pacing stimuli were delivered to the center of the plaque. Pacing period (Tp) was decreased from 275 ± 25 msec to 75 ± 25 msec and then increased to 230 ± 70 msec in steps of either 5 or 10 msec. In all 21 trials in six sheep, the atrium responded 1:1 at longer Tps and 2:1 at shorter Tps. As Tp was decreased, the response switched to 2:1 at a particular Tp. Conversely, as Tp was increased, the response switched back to 1:1 at a particular Tp. Over 21 trials, the l:1-to-2:l and 2:l-to-l:l transitions occurred at 119.5 ± 18.8 msec and 130.0 ± 19.1 m.sec, respectively. This hysteretic behavior yielded bistability windows. 10.5 ± 7.2 msec wide, wherein 1:1 and 2:1 responses existed at the same Tp. In 15 trials and in all animals, idiopathic wavefronts emanating from outside the mapped region passed through the mapped region. In 13 of those trials, the idiopathic wavefronts occurred at Tps within the bistability window or within 35 msec of its upper or lower limit. Conclusion: Bistability windows and idiopathic wavefronts were observed and found to be correlated with each other, suggesting a connection between bistability and arrhythmogenesis. |
| abstract_unstemmed |
Bistability and Arrhythmogenesis in Paced Sheep Atria. Introduction: Studies of the electrical dynamics of cardiac tissue are important for understanding the mechanisms of arrhythmias. This study uses high-frequency pacing to investigate the dynamics of sheep atria. Methods and Results: A 504-electrode mapping plaque was affixed to the right atrium in six sheep. Cathodal pacing stimuli were delivered to the center of the plaque. Pacing period (Tp) was decreased from 275 ± 25 msec to 75 ± 25 msec and then increased to 230 ± 70 msec in steps of either 5 or 10 msec. In all 21 trials in six sheep, the atrium responded 1:1 at longer Tps and 2:1 at shorter Tps. As Tp was decreased, the response switched to 2:1 at a particular Tp. Conversely, as Tp was increased, the response switched back to 1:1 at a particular Tp. Over 21 trials, the l:1-to-2:l and 2:l-to-l:l transitions occurred at 119.5 ± 18.8 msec and 130.0 ± 19.1 m.sec, respectively. This hysteretic behavior yielded bistability windows. 10.5 ± 7.2 msec wide, wherein 1:1 and 2:1 responses existed at the same Tp. In 15 trials and in all animals, idiopathic wavefronts emanating from outside the mapped region passed through the mapped region. In 13 of those trials, the idiopathic wavefronts occurred at Tps within the bistability window or within 35 msec of its upper or lower limit. Conclusion: Bistability windows and idiopathic wavefronts were observed and found to be correlated with each other, suggesting a connection between bistability and arrhythmogenesis. |
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Existence of Bistability and Correlation with Arrhythmogenesis in Paced Sheep Atria |
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HALL, G. MARTIN Ph.D. BAHAR, SONYA Ph.D. KRASSOWSKA, WANDA Ph.D. WOLF, PATRICK D. Ph.D. TULLOCH, ELLEN G. DIXON M.S. GAUTHIER, DANIEL J. Ph.D. |
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HALL, G. MARTIN Ph.D. BAHAR, SONYA Ph.D. KRASSOWSKA, WANDA Ph.D. WOLF, PATRICK D. Ph.D. TULLOCH, ELLEN G. DIXON M.S. GAUTHIER, DANIEL J. Ph.D. |
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