Glomerular expression of connective tissue growth factor mRNA in various renal diseases
SUMMARY: Connective tissue growth factor (CTGF) is a cysteine-rich member of a new family of growth regulators. It is an important factor in the pathogenesis of mesangial matrix accumulation and progressive glomerulosclerosis. The present study was designed to elucidate the role of CTGF in diabetic...
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E-Artikel |
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Melbourne, Australia: Blackwell Science Pty ; 2003 |
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Online-Ressource |
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| Reproduktion: |
2003 ; Blackwell Publishing Journal Backfiles 1879-2005 |
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| Übergeordnetes Werk: |
In: Nephrology - Oxford [u.a.] : Wiley-Blackwell, 1995, 8(2003), 2, Seite 0 |
| Übergeordnetes Werk: |
volume:8 ; year:2003 ; number:2 ; pages:0 |
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| DOI / URN: |
10.1046/j.1440-1797.2003.00142.x |
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NLEJ243510160 |
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| 520 | |a SUMMARY: Connective tissue growth factor (CTGF) is a cysteine-rich member of a new family of growth regulators. It is an important factor in the pathogenesis of mesangial matrix accumulation and progressive glomerulosclerosis. The present study was designed to elucidate the role of CTGF in diabetic nephropathy (DN), immunoglobulin A nephropathy (IgA-N), membranous nephropathy (MN), and minimal change nephrotic syndrome (MCNS). We evaluated the expression and localization of CTGF mRNA in surgically excised renal tissue samples from 10 patients with DN, 10 with IgA-N, 10 with MN, 10 with MCNS, and 10 normal human kidney (NHK) tissue samples, by using high-resolution in situ hybridization with digoxigenin-labelled oligonucleotide. To quantify CTGF mRNA expression, we counted all nuclei, and nuclei surrounded by CTGF-positive cytoplasm, in at least 10 randomly selected cross-sections of non-sclerotic glomeruli, and expressed the results as a percentage of total glomerular cells. In all glomeruli, CTGF mRNA was expressed mainly in glomerular intrinsic cells, including glomerular mesangial and epithelial cells and some cells of Bowman's capsule. The percentage of cells positive for CTGF mRNA was significantly higher in DN and IgA-N than in MN, MCNS and NHK. However, there was no significant difference in the percentage of CTGF mRNA-positive cells between DN and IgA-N. Our study indicates that CTGF may play an important role in the development and progression of glomerulosclerosis in DN and IgA-N, which are both accompanied by mesangial matrix expansion and comprise two major causes of end-stage renal failure. | ||
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10.1046/j.1440-1797.2003.00142.x doi (DE-627)NLEJ243510160 DE-627 ger DE-627 rakwb Glomerular expression of connective tissue growth factor mRNA in various renal diseases Melbourne, Australia Blackwell Science Pty 2003 Online-Ressource nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier SUMMARY: Connective tissue growth factor (CTGF) is a cysteine-rich member of a new family of growth regulators. It is an important factor in the pathogenesis of mesangial matrix accumulation and progressive glomerulosclerosis. The present study was designed to elucidate the role of CTGF in diabetic nephropathy (DN), immunoglobulin A nephropathy (IgA-N), membranous nephropathy (MN), and minimal change nephrotic syndrome (MCNS). We evaluated the expression and localization of CTGF mRNA in surgically excised renal tissue samples from 10 patients with DN, 10 with IgA-N, 10 with MN, 10 with MCNS, and 10 normal human kidney (NHK) tissue samples, by using high-resolution in situ hybridization with digoxigenin-labelled oligonucleotide. To quantify CTGF mRNA expression, we counted all nuclei, and nuclei surrounded by CTGF-positive cytoplasm, in at least 10 randomly selected cross-sections of non-sclerotic glomeruli, and expressed the results as a percentage of total glomerular cells. In all glomeruli, CTGF mRNA was expressed mainly in glomerular intrinsic cells, including glomerular mesangial and epithelial cells and some cells of Bowman's capsule. The percentage of cells positive for CTGF mRNA was significantly higher in DN and IgA-N than in MN, MCNS and NHK. However, there was no significant difference in the percentage of CTGF mRNA-positive cells between DN and IgA-N. Our study indicates that CTGF may play an important role in the development and progression of glomerulosclerosis in DN and IgA-N, which are both accompanied by mesangial matrix expansion and comprise two major causes of end-stage renal failure. 2003 Blackwell Publishing Journal Backfiles 1879-2005 |2003|||||||||| connective tissue growth factor SUZUKI, Daisuke oth TOYODA, Masao oth UMEZONO, Tomoya oth UEHARA, Goro oth ZHANG, Shao-Yu oth SAKAI, Takako oth NISHINA, Makoto oth SUGA, Takao oth ENDOH, Masayuki oth YAGAME, Mitsunori oth SAKAI, Hideto oth In Nephrology Oxford [u.a.] : Wiley-Blackwell, 1995 8(2003), 2, Seite 0 Online-Ressource (DE-627)NLEJ243925859 (DE-600)2008235-6 1440-1797 nnns volume:8 year:2003 number:2 pages:0 http://dx.doi.org/10.1046/j.1440-1797.2003.00142.x text/html Verlag Deutschlandweit zugänglich Volltext GBV_USEFLAG_U ZDB-1-DJB GBV_NL_ARTICLE AR 8 2003 2 0 |
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10.1046/j.1440-1797.2003.00142.x doi (DE-627)NLEJ243510160 DE-627 ger DE-627 rakwb Glomerular expression of connective tissue growth factor mRNA in various renal diseases Melbourne, Australia Blackwell Science Pty 2003 Online-Ressource nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier SUMMARY: Connective tissue growth factor (CTGF) is a cysteine-rich member of a new family of growth regulators. It is an important factor in the pathogenesis of mesangial matrix accumulation and progressive glomerulosclerosis. The present study was designed to elucidate the role of CTGF in diabetic nephropathy (DN), immunoglobulin A nephropathy (IgA-N), membranous nephropathy (MN), and minimal change nephrotic syndrome (MCNS). We evaluated the expression and localization of CTGF mRNA in surgically excised renal tissue samples from 10 patients with DN, 10 with IgA-N, 10 with MN, 10 with MCNS, and 10 normal human kidney (NHK) tissue samples, by using high-resolution in situ hybridization with digoxigenin-labelled oligonucleotide. To quantify CTGF mRNA expression, we counted all nuclei, and nuclei surrounded by CTGF-positive cytoplasm, in at least 10 randomly selected cross-sections of non-sclerotic glomeruli, and expressed the results as a percentage of total glomerular cells. In all glomeruli, CTGF mRNA was expressed mainly in glomerular intrinsic cells, including glomerular mesangial and epithelial cells and some cells of Bowman's capsule. The percentage of cells positive for CTGF mRNA was significantly higher in DN and IgA-N than in MN, MCNS and NHK. However, there was no significant difference in the percentage of CTGF mRNA-positive cells between DN and IgA-N. Our study indicates that CTGF may play an important role in the development and progression of glomerulosclerosis in DN and IgA-N, which are both accompanied by mesangial matrix expansion and comprise two major causes of end-stage renal failure. 2003 Blackwell Publishing Journal Backfiles 1879-2005 |2003|||||||||| connective tissue growth factor SUZUKI, Daisuke oth TOYODA, Masao oth UMEZONO, Tomoya oth UEHARA, Goro oth ZHANG, Shao-Yu oth SAKAI, Takako oth NISHINA, Makoto oth SUGA, Takao oth ENDOH, Masayuki oth YAGAME, Mitsunori oth SAKAI, Hideto oth In Nephrology Oxford [u.a.] : Wiley-Blackwell, 1995 8(2003), 2, Seite 0 Online-Ressource (DE-627)NLEJ243925859 (DE-600)2008235-6 1440-1797 nnns volume:8 year:2003 number:2 pages:0 http://dx.doi.org/10.1046/j.1440-1797.2003.00142.x text/html Verlag Deutschlandweit zugänglich Volltext GBV_USEFLAG_U ZDB-1-DJB GBV_NL_ARTICLE AR 8 2003 2 0 |
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10.1046/j.1440-1797.2003.00142.x doi (DE-627)NLEJ243510160 DE-627 ger DE-627 rakwb Glomerular expression of connective tissue growth factor mRNA in various renal diseases Melbourne, Australia Blackwell Science Pty 2003 Online-Ressource nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier SUMMARY: Connective tissue growth factor (CTGF) is a cysteine-rich member of a new family of growth regulators. It is an important factor in the pathogenesis of mesangial matrix accumulation and progressive glomerulosclerosis. The present study was designed to elucidate the role of CTGF in diabetic nephropathy (DN), immunoglobulin A nephropathy (IgA-N), membranous nephropathy (MN), and minimal change nephrotic syndrome (MCNS). We evaluated the expression and localization of CTGF mRNA in surgically excised renal tissue samples from 10 patients with DN, 10 with IgA-N, 10 with MN, 10 with MCNS, and 10 normal human kidney (NHK) tissue samples, by using high-resolution in situ hybridization with digoxigenin-labelled oligonucleotide. To quantify CTGF mRNA expression, we counted all nuclei, and nuclei surrounded by CTGF-positive cytoplasm, in at least 10 randomly selected cross-sections of non-sclerotic glomeruli, and expressed the results as a percentage of total glomerular cells. In all glomeruli, CTGF mRNA was expressed mainly in glomerular intrinsic cells, including glomerular mesangial and epithelial cells and some cells of Bowman's capsule. The percentage of cells positive for CTGF mRNA was significantly higher in DN and IgA-N than in MN, MCNS and NHK. However, there was no significant difference in the percentage of CTGF mRNA-positive cells between DN and IgA-N. Our study indicates that CTGF may play an important role in the development and progression of glomerulosclerosis in DN and IgA-N, which are both accompanied by mesangial matrix expansion and comprise two major causes of end-stage renal failure. 2003 Blackwell Publishing Journal Backfiles 1879-2005 |2003|||||||||| connective tissue growth factor SUZUKI, Daisuke oth TOYODA, Masao oth UMEZONO, Tomoya oth UEHARA, Goro oth ZHANG, Shao-Yu oth SAKAI, Takako oth NISHINA, Makoto oth SUGA, Takao oth ENDOH, Masayuki oth YAGAME, Mitsunori oth SAKAI, Hideto oth In Nephrology Oxford [u.a.] : Wiley-Blackwell, 1995 8(2003), 2, Seite 0 Online-Ressource (DE-627)NLEJ243925859 (DE-600)2008235-6 1440-1797 nnns volume:8 year:2003 number:2 pages:0 http://dx.doi.org/10.1046/j.1440-1797.2003.00142.x text/html Verlag Deutschlandweit zugänglich Volltext GBV_USEFLAG_U ZDB-1-DJB GBV_NL_ARTICLE AR 8 2003 2 0 |
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10.1046/j.1440-1797.2003.00142.x doi (DE-627)NLEJ243510160 DE-627 ger DE-627 rakwb Glomerular expression of connective tissue growth factor mRNA in various renal diseases Melbourne, Australia Blackwell Science Pty 2003 Online-Ressource nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier SUMMARY: Connective tissue growth factor (CTGF) is a cysteine-rich member of a new family of growth regulators. It is an important factor in the pathogenesis of mesangial matrix accumulation and progressive glomerulosclerosis. The present study was designed to elucidate the role of CTGF in diabetic nephropathy (DN), immunoglobulin A nephropathy (IgA-N), membranous nephropathy (MN), and minimal change nephrotic syndrome (MCNS). We evaluated the expression and localization of CTGF mRNA in surgically excised renal tissue samples from 10 patients with DN, 10 with IgA-N, 10 with MN, 10 with MCNS, and 10 normal human kidney (NHK) tissue samples, by using high-resolution in situ hybridization with digoxigenin-labelled oligonucleotide. To quantify CTGF mRNA expression, we counted all nuclei, and nuclei surrounded by CTGF-positive cytoplasm, in at least 10 randomly selected cross-sections of non-sclerotic glomeruli, and expressed the results as a percentage of total glomerular cells. In all glomeruli, CTGF mRNA was expressed mainly in glomerular intrinsic cells, including glomerular mesangial and epithelial cells and some cells of Bowman's capsule. The percentage of cells positive for CTGF mRNA was significantly higher in DN and IgA-N than in MN, MCNS and NHK. However, there was no significant difference in the percentage of CTGF mRNA-positive cells between DN and IgA-N. Our study indicates that CTGF may play an important role in the development and progression of glomerulosclerosis in DN and IgA-N, which are both accompanied by mesangial matrix expansion and comprise two major causes of end-stage renal failure. 2003 Blackwell Publishing Journal Backfiles 1879-2005 |2003|||||||||| connective tissue growth factor SUZUKI, Daisuke oth TOYODA, Masao oth UMEZONO, Tomoya oth UEHARA, Goro oth ZHANG, Shao-Yu oth SAKAI, Takako oth NISHINA, Makoto oth SUGA, Takao oth ENDOH, Masayuki oth YAGAME, Mitsunori oth SAKAI, Hideto oth In Nephrology Oxford [u.a.] : Wiley-Blackwell, 1995 8(2003), 2, Seite 0 Online-Ressource (DE-627)NLEJ243925859 (DE-600)2008235-6 1440-1797 nnns volume:8 year:2003 number:2 pages:0 http://dx.doi.org/10.1046/j.1440-1797.2003.00142.x text/html Verlag Deutschlandweit zugänglich Volltext GBV_USEFLAG_U ZDB-1-DJB GBV_NL_ARTICLE AR 8 2003 2 0 |
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10.1046/j.1440-1797.2003.00142.x doi (DE-627)NLEJ243510160 DE-627 ger DE-627 rakwb Glomerular expression of connective tissue growth factor mRNA in various renal diseases Melbourne, Australia Blackwell Science Pty 2003 Online-Ressource nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier SUMMARY: Connective tissue growth factor (CTGF) is a cysteine-rich member of a new family of growth regulators. It is an important factor in the pathogenesis of mesangial matrix accumulation and progressive glomerulosclerosis. The present study was designed to elucidate the role of CTGF in diabetic nephropathy (DN), immunoglobulin A nephropathy (IgA-N), membranous nephropathy (MN), and minimal change nephrotic syndrome (MCNS). We evaluated the expression and localization of CTGF mRNA in surgically excised renal tissue samples from 10 patients with DN, 10 with IgA-N, 10 with MN, 10 with MCNS, and 10 normal human kidney (NHK) tissue samples, by using high-resolution in situ hybridization with digoxigenin-labelled oligonucleotide. To quantify CTGF mRNA expression, we counted all nuclei, and nuclei surrounded by CTGF-positive cytoplasm, in at least 10 randomly selected cross-sections of non-sclerotic glomeruli, and expressed the results as a percentage of total glomerular cells. In all glomeruli, CTGF mRNA was expressed mainly in glomerular intrinsic cells, including glomerular mesangial and epithelial cells and some cells of Bowman's capsule. The percentage of cells positive for CTGF mRNA was significantly higher in DN and IgA-N than in MN, MCNS and NHK. However, there was no significant difference in the percentage of CTGF mRNA-positive cells between DN and IgA-N. Our study indicates that CTGF may play an important role in the development and progression of glomerulosclerosis in DN and IgA-N, which are both accompanied by mesangial matrix expansion and comprise two major causes of end-stage renal failure. 2003 Blackwell Publishing Journal Backfiles 1879-2005 |2003|||||||||| connective tissue growth factor SUZUKI, Daisuke oth TOYODA, Masao oth UMEZONO, Tomoya oth UEHARA, Goro oth ZHANG, Shao-Yu oth SAKAI, Takako oth NISHINA, Makoto oth SUGA, Takao oth ENDOH, Masayuki oth YAGAME, Mitsunori oth SAKAI, Hideto oth In Nephrology Oxford [u.a.] : Wiley-Blackwell, 1995 8(2003), 2, Seite 0 Online-Ressource (DE-627)NLEJ243925859 (DE-600)2008235-6 1440-1797 nnns volume:8 year:2003 number:2 pages:0 http://dx.doi.org/10.1046/j.1440-1797.2003.00142.x text/html Verlag Deutschlandweit zugänglich Volltext GBV_USEFLAG_U ZDB-1-DJB GBV_NL_ARTICLE AR 8 2003 2 0 |
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Glomerular expression of connective tissue growth factor mRNA in various renal diseases |
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Glomerular expression of connective tissue growth factor mRNA in various renal diseases |
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Nephrology |
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10.1046/j.1440-1797.2003.00142.x |
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glomerular expression of connective tissue growth factor mrna in various renal diseases |
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Glomerular expression of connective tissue growth factor mRNA in various renal diseases |
| abstract |
SUMMARY: Connective tissue growth factor (CTGF) is a cysteine-rich member of a new family of growth regulators. It is an important factor in the pathogenesis of mesangial matrix accumulation and progressive glomerulosclerosis. The present study was designed to elucidate the role of CTGF in diabetic nephropathy (DN), immunoglobulin A nephropathy (IgA-N), membranous nephropathy (MN), and minimal change nephrotic syndrome (MCNS). We evaluated the expression and localization of CTGF mRNA in surgically excised renal tissue samples from 10 patients with DN, 10 with IgA-N, 10 with MN, 10 with MCNS, and 10 normal human kidney (NHK) tissue samples, by using high-resolution in situ hybridization with digoxigenin-labelled oligonucleotide. To quantify CTGF mRNA expression, we counted all nuclei, and nuclei surrounded by CTGF-positive cytoplasm, in at least 10 randomly selected cross-sections of non-sclerotic glomeruli, and expressed the results as a percentage of total glomerular cells. In all glomeruli, CTGF mRNA was expressed mainly in glomerular intrinsic cells, including glomerular mesangial and epithelial cells and some cells of Bowman's capsule. The percentage of cells positive for CTGF mRNA was significantly higher in DN and IgA-N than in MN, MCNS and NHK. However, there was no significant difference in the percentage of CTGF mRNA-positive cells between DN and IgA-N. Our study indicates that CTGF may play an important role in the development and progression of glomerulosclerosis in DN and IgA-N, which are both accompanied by mesangial matrix expansion and comprise two major causes of end-stage renal failure. |
| abstractGer |
SUMMARY: Connective tissue growth factor (CTGF) is a cysteine-rich member of a new family of growth regulators. It is an important factor in the pathogenesis of mesangial matrix accumulation and progressive glomerulosclerosis. The present study was designed to elucidate the role of CTGF in diabetic nephropathy (DN), immunoglobulin A nephropathy (IgA-N), membranous nephropathy (MN), and minimal change nephrotic syndrome (MCNS). We evaluated the expression and localization of CTGF mRNA in surgically excised renal tissue samples from 10 patients with DN, 10 with IgA-N, 10 with MN, 10 with MCNS, and 10 normal human kidney (NHK) tissue samples, by using high-resolution in situ hybridization with digoxigenin-labelled oligonucleotide. To quantify CTGF mRNA expression, we counted all nuclei, and nuclei surrounded by CTGF-positive cytoplasm, in at least 10 randomly selected cross-sections of non-sclerotic glomeruli, and expressed the results as a percentage of total glomerular cells. In all glomeruli, CTGF mRNA was expressed mainly in glomerular intrinsic cells, including glomerular mesangial and epithelial cells and some cells of Bowman's capsule. The percentage of cells positive for CTGF mRNA was significantly higher in DN and IgA-N than in MN, MCNS and NHK. However, there was no significant difference in the percentage of CTGF mRNA-positive cells between DN and IgA-N. Our study indicates that CTGF may play an important role in the development and progression of glomerulosclerosis in DN and IgA-N, which are both accompanied by mesangial matrix expansion and comprise two major causes of end-stage renal failure. |
| abstract_unstemmed |
SUMMARY: Connective tissue growth factor (CTGF) is a cysteine-rich member of a new family of growth regulators. It is an important factor in the pathogenesis of mesangial matrix accumulation and progressive glomerulosclerosis. The present study was designed to elucidate the role of CTGF in diabetic nephropathy (DN), immunoglobulin A nephropathy (IgA-N), membranous nephropathy (MN), and minimal change nephrotic syndrome (MCNS). We evaluated the expression and localization of CTGF mRNA in surgically excised renal tissue samples from 10 patients with DN, 10 with IgA-N, 10 with MN, 10 with MCNS, and 10 normal human kidney (NHK) tissue samples, by using high-resolution in situ hybridization with digoxigenin-labelled oligonucleotide. To quantify CTGF mRNA expression, we counted all nuclei, and nuclei surrounded by CTGF-positive cytoplasm, in at least 10 randomly selected cross-sections of non-sclerotic glomeruli, and expressed the results as a percentage of total glomerular cells. In all glomeruli, CTGF mRNA was expressed mainly in glomerular intrinsic cells, including glomerular mesangial and epithelial cells and some cells of Bowman's capsule. The percentage of cells positive for CTGF mRNA was significantly higher in DN and IgA-N than in MN, MCNS and NHK. However, there was no significant difference in the percentage of CTGF mRNA-positive cells between DN and IgA-N. Our study indicates that CTGF may play an important role in the development and progression of glomerulosclerosis in DN and IgA-N, which are both accompanied by mesangial matrix expansion and comprise two major causes of end-stage renal failure. |
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Glomerular expression of connective tissue growth factor mRNA in various renal diseases |
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SUZUKI, Daisuke TOYODA, Masao UMEZONO, Tomoya UEHARA, Goro ZHANG, Shao-Yu SAKAI, Takako NISHINA, Makoto SUGA, Takao ENDOH, Masayuki YAGAME, Mitsunori SAKAI, Hideto |
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