In vitro suppression of parathyroid hormone secretion by 22-oxa-calcitriol in human parathyroid hyperplasia due to uraermia
SUMMARY: 22-oxa-calcitriol (OCT), a vitamin D analogue, suppresses parathyroid hormone (PTH) secretion and has less calcaemic activity than 1,25-dihydroxyvitamin D3 [1,25(OH)2D3] in vivo. In this study, we evaluated the effect of OCT on PTH secretion in vitro using human hyperplastic parathyroid tis...
Ausführliche Beschreibung
Gespeichert in:
| Autor*in: |
SATO, Keisuke [verfasserIn] TOMINAGA, Yoshihiro [verfasserIn] ICHIKAWA, Fumihiko [verfasserIn] |
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| Format: |
E-Artikel |
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| Erschienen: |
Oxford, UK: Blackwell Publishing Ltd ; 1998 |
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| Schlagwörter: |
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| Umfang: |
Online-Ressource |
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| Reproduktion: |
2008 ; Blackwell Publishing Journal Backfiles 1879-2005 |
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| Übergeordnetes Werk: |
In: Nephrology - Oxford [u.a.] : Wiley-Blackwell, 1995, 4(1998), 3, Seite 0 |
| Übergeordnetes Werk: |
volume:4 ; year:1998 ; number:3 ; pages:0 |
| Links: |
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| DOI / URN: |
10.1046/j.1440-1797.1998.d01-28.x |
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NLEJ243517475 |
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| 245 | 1 | 0 | |a In vitro suppression of parathyroid hormone secretion by 22-oxa-calcitriol in human parathyroid hyperplasia due to uraermia |
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| 520 | |a SUMMARY: 22-oxa-calcitriol (OCT), a vitamin D analogue, suppresses parathyroid hormone (PTH) secretion and has less calcaemic activity than 1,25-dihydroxyvitamin D3 [1,25(OH)2D3] in vivo. In this study, we evaluated the effect of OCT on PTH secretion in vitro using human hyperplastic parathyroid tissue obtained during surgery for advanced renal hyperparathyroidism and normal bovine parathyroid glands to compare the effects of 1,25(OH)2D3. 22-oxa-calcitriol suppressed PTH secretion by nodular hyperplastic parathyroid tissue and normal bovine tissue in a dose dependent manner, the same as 1,25(OH)2D3. We showed the additive effect of extracellular calcium level on suppression of PTH secretion by OCT and 1,25(OH)2D3. These results suggest that OCT suppresses PTH secretion, the same as 1,25(OH)2D3 not only in normal parathyroid cells but also on hyperplastic parathyroid cells. | ||
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| 700 | 1 | |a TAKEZAWA, Jun-ichi |4 oth | |
| 700 | 1 | |a TSUCHIYA, Takeshi |4 oth | |
| 700 | 1 | |a KUBODERA, Noboru |4 oth | |
| 700 | 1 | |a TAKAGI, Hiroshi |4 oth | |
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10.1046/j.1440-1797.1998.d01-28.x doi (DE-627)NLEJ243517475 DE-627 ger DE-627 rakwb SATO, Keisuke verfasserin aut In vitro suppression of parathyroid hormone secretion by 22-oxa-calcitriol in human parathyroid hyperplasia due to uraermia Oxford, UK Blackwell Publishing Ltd 1998 Online-Ressource nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier SUMMARY: 22-oxa-calcitriol (OCT), a vitamin D analogue, suppresses parathyroid hormone (PTH) secretion and has less calcaemic activity than 1,25-dihydroxyvitamin D3 [1,25(OH)2D3] in vivo. In this study, we evaluated the effect of OCT on PTH secretion in vitro using human hyperplastic parathyroid tissue obtained during surgery for advanced renal hyperparathyroidism and normal bovine parathyroid glands to compare the effects of 1,25(OH)2D3. 22-oxa-calcitriol suppressed PTH secretion by nodular hyperplastic parathyroid tissue and normal bovine tissue in a dose dependent manner, the same as 1,25(OH)2D3. We showed the additive effect of extracellular calcium level on suppression of PTH secretion by OCT and 1,25(OH)2D3. These results suggest that OCT suppresses PTH secretion, the same as 1,25(OH)2D3 not only in normal parathyroid cells but also on hyperplastic parathyroid cells. 2008 Blackwell Publishing Journal Backfiles 1879-2005 |2008|||||||||| 22-oxa-calcitriol TOMINAGA, Yoshihiro verfasserin aut ICHIKAWA, Fumihiko verfasserin aut UCHIDA, Kazuharu oth TAKEZAWA, Jun-ichi oth TSUCHIYA, Takeshi oth KUBODERA, Noboru oth TAKAGI, Hiroshi oth In Nephrology Oxford [u.a.] : Wiley-Blackwell, 1995 4(1998), 3, Seite 0 Online-Ressource (DE-627)NLEJ243925859 (DE-600)2008235-6 1440-1797 nnns volume:4 year:1998 number:3 pages:0 http://dx.doi.org/10.1046/j.1440-1797.1998.d01-28.x text/html Verlag Deutschlandweit zugänglich Volltext GBV_USEFLAG_U ZDB-1-DJB GBV_NL_ARTICLE AR 4 1998 3 0 |
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10.1046/j.1440-1797.1998.d01-28.x doi (DE-627)NLEJ243517475 DE-627 ger DE-627 rakwb SATO, Keisuke verfasserin aut In vitro suppression of parathyroid hormone secretion by 22-oxa-calcitriol in human parathyroid hyperplasia due to uraermia Oxford, UK Blackwell Publishing Ltd 1998 Online-Ressource nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier SUMMARY: 22-oxa-calcitriol (OCT), a vitamin D analogue, suppresses parathyroid hormone (PTH) secretion and has less calcaemic activity than 1,25-dihydroxyvitamin D3 [1,25(OH)2D3] in vivo. In this study, we evaluated the effect of OCT on PTH secretion in vitro using human hyperplastic parathyroid tissue obtained during surgery for advanced renal hyperparathyroidism and normal bovine parathyroid glands to compare the effects of 1,25(OH)2D3. 22-oxa-calcitriol suppressed PTH secretion by nodular hyperplastic parathyroid tissue and normal bovine tissue in a dose dependent manner, the same as 1,25(OH)2D3. We showed the additive effect of extracellular calcium level on suppression of PTH secretion by OCT and 1,25(OH)2D3. These results suggest that OCT suppresses PTH secretion, the same as 1,25(OH)2D3 not only in normal parathyroid cells but also on hyperplastic parathyroid cells. 2008 Blackwell Publishing Journal Backfiles 1879-2005 |2008|||||||||| 22-oxa-calcitriol TOMINAGA, Yoshihiro verfasserin aut ICHIKAWA, Fumihiko verfasserin aut UCHIDA, Kazuharu oth TAKEZAWA, Jun-ichi oth TSUCHIYA, Takeshi oth KUBODERA, Noboru oth TAKAGI, Hiroshi oth In Nephrology Oxford [u.a.] : Wiley-Blackwell, 1995 4(1998), 3, Seite 0 Online-Ressource (DE-627)NLEJ243925859 (DE-600)2008235-6 1440-1797 nnns volume:4 year:1998 number:3 pages:0 http://dx.doi.org/10.1046/j.1440-1797.1998.d01-28.x text/html Verlag Deutschlandweit zugänglich Volltext GBV_USEFLAG_U ZDB-1-DJB GBV_NL_ARTICLE AR 4 1998 3 0 |
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10.1046/j.1440-1797.1998.d01-28.x doi (DE-627)NLEJ243517475 DE-627 ger DE-627 rakwb SATO, Keisuke verfasserin aut In vitro suppression of parathyroid hormone secretion by 22-oxa-calcitriol in human parathyroid hyperplasia due to uraermia Oxford, UK Blackwell Publishing Ltd 1998 Online-Ressource nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier SUMMARY: 22-oxa-calcitriol (OCT), a vitamin D analogue, suppresses parathyroid hormone (PTH) secretion and has less calcaemic activity than 1,25-dihydroxyvitamin D3 [1,25(OH)2D3] in vivo. In this study, we evaluated the effect of OCT on PTH secretion in vitro using human hyperplastic parathyroid tissue obtained during surgery for advanced renal hyperparathyroidism and normal bovine parathyroid glands to compare the effects of 1,25(OH)2D3. 22-oxa-calcitriol suppressed PTH secretion by nodular hyperplastic parathyroid tissue and normal bovine tissue in a dose dependent manner, the same as 1,25(OH)2D3. We showed the additive effect of extracellular calcium level on suppression of PTH secretion by OCT and 1,25(OH)2D3. These results suggest that OCT suppresses PTH secretion, the same as 1,25(OH)2D3 not only in normal parathyroid cells but also on hyperplastic parathyroid cells. 2008 Blackwell Publishing Journal Backfiles 1879-2005 |2008|||||||||| 22-oxa-calcitriol TOMINAGA, Yoshihiro verfasserin aut ICHIKAWA, Fumihiko verfasserin aut UCHIDA, Kazuharu oth TAKEZAWA, Jun-ichi oth TSUCHIYA, Takeshi oth KUBODERA, Noboru oth TAKAGI, Hiroshi oth In Nephrology Oxford [u.a.] : Wiley-Blackwell, 1995 4(1998), 3, Seite 0 Online-Ressource (DE-627)NLEJ243925859 (DE-600)2008235-6 1440-1797 nnns volume:4 year:1998 number:3 pages:0 http://dx.doi.org/10.1046/j.1440-1797.1998.d01-28.x text/html Verlag Deutschlandweit zugänglich Volltext GBV_USEFLAG_U ZDB-1-DJB GBV_NL_ARTICLE AR 4 1998 3 0 |
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10.1046/j.1440-1797.1998.d01-28.x doi (DE-627)NLEJ243517475 DE-627 ger DE-627 rakwb SATO, Keisuke verfasserin aut In vitro suppression of parathyroid hormone secretion by 22-oxa-calcitriol in human parathyroid hyperplasia due to uraermia Oxford, UK Blackwell Publishing Ltd 1998 Online-Ressource nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier SUMMARY: 22-oxa-calcitriol (OCT), a vitamin D analogue, suppresses parathyroid hormone (PTH) secretion and has less calcaemic activity than 1,25-dihydroxyvitamin D3 [1,25(OH)2D3] in vivo. In this study, we evaluated the effect of OCT on PTH secretion in vitro using human hyperplastic parathyroid tissue obtained during surgery for advanced renal hyperparathyroidism and normal bovine parathyroid glands to compare the effects of 1,25(OH)2D3. 22-oxa-calcitriol suppressed PTH secretion by nodular hyperplastic parathyroid tissue and normal bovine tissue in a dose dependent manner, the same as 1,25(OH)2D3. We showed the additive effect of extracellular calcium level on suppression of PTH secretion by OCT and 1,25(OH)2D3. These results suggest that OCT suppresses PTH secretion, the same as 1,25(OH)2D3 not only in normal parathyroid cells but also on hyperplastic parathyroid cells. 2008 Blackwell Publishing Journal Backfiles 1879-2005 |2008|||||||||| 22-oxa-calcitriol TOMINAGA, Yoshihiro verfasserin aut ICHIKAWA, Fumihiko verfasserin aut UCHIDA, Kazuharu oth TAKEZAWA, Jun-ichi oth TSUCHIYA, Takeshi oth KUBODERA, Noboru oth TAKAGI, Hiroshi oth In Nephrology Oxford [u.a.] : Wiley-Blackwell, 1995 4(1998), 3, Seite 0 Online-Ressource (DE-627)NLEJ243925859 (DE-600)2008235-6 1440-1797 nnns volume:4 year:1998 number:3 pages:0 http://dx.doi.org/10.1046/j.1440-1797.1998.d01-28.x text/html Verlag Deutschlandweit zugänglich Volltext GBV_USEFLAG_U ZDB-1-DJB GBV_NL_ARTICLE AR 4 1998 3 0 |
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10.1046/j.1440-1797.1998.d01-28.x doi (DE-627)NLEJ243517475 DE-627 ger DE-627 rakwb SATO, Keisuke verfasserin aut In vitro suppression of parathyroid hormone secretion by 22-oxa-calcitriol in human parathyroid hyperplasia due to uraermia Oxford, UK Blackwell Publishing Ltd 1998 Online-Ressource nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier SUMMARY: 22-oxa-calcitriol (OCT), a vitamin D analogue, suppresses parathyroid hormone (PTH) secretion and has less calcaemic activity than 1,25-dihydroxyvitamin D3 [1,25(OH)2D3] in vivo. In this study, we evaluated the effect of OCT on PTH secretion in vitro using human hyperplastic parathyroid tissue obtained during surgery for advanced renal hyperparathyroidism and normal bovine parathyroid glands to compare the effects of 1,25(OH)2D3. 22-oxa-calcitriol suppressed PTH secretion by nodular hyperplastic parathyroid tissue and normal bovine tissue in a dose dependent manner, the same as 1,25(OH)2D3. We showed the additive effect of extracellular calcium level on suppression of PTH secretion by OCT and 1,25(OH)2D3. These results suggest that OCT suppresses PTH secretion, the same as 1,25(OH)2D3 not only in normal parathyroid cells but also on hyperplastic parathyroid cells. 2008 Blackwell Publishing Journal Backfiles 1879-2005 |2008|||||||||| 22-oxa-calcitriol TOMINAGA, Yoshihiro verfasserin aut ICHIKAWA, Fumihiko verfasserin aut UCHIDA, Kazuharu oth TAKEZAWA, Jun-ichi oth TSUCHIYA, Takeshi oth KUBODERA, Noboru oth TAKAGI, Hiroshi oth In Nephrology Oxford [u.a.] : Wiley-Blackwell, 1995 4(1998), 3, Seite 0 Online-Ressource (DE-627)NLEJ243925859 (DE-600)2008235-6 1440-1797 nnns volume:4 year:1998 number:3 pages:0 http://dx.doi.org/10.1046/j.1440-1797.1998.d01-28.x text/html Verlag Deutschlandweit zugänglich Volltext GBV_USEFLAG_U ZDB-1-DJB GBV_NL_ARTICLE AR 4 1998 3 0 |
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In vitro suppression of parathyroid hormone secretion by 22-oxa-calcitriol in human parathyroid hyperplasia due to uraermia |
| abstract |
SUMMARY: 22-oxa-calcitriol (OCT), a vitamin D analogue, suppresses parathyroid hormone (PTH) secretion and has less calcaemic activity than 1,25-dihydroxyvitamin D3 [1,25(OH)2D3] in vivo. In this study, we evaluated the effect of OCT on PTH secretion in vitro using human hyperplastic parathyroid tissue obtained during surgery for advanced renal hyperparathyroidism and normal bovine parathyroid glands to compare the effects of 1,25(OH)2D3. 22-oxa-calcitriol suppressed PTH secretion by nodular hyperplastic parathyroid tissue and normal bovine tissue in a dose dependent manner, the same as 1,25(OH)2D3. We showed the additive effect of extracellular calcium level on suppression of PTH secretion by OCT and 1,25(OH)2D3. These results suggest that OCT suppresses PTH secretion, the same as 1,25(OH)2D3 not only in normal parathyroid cells but also on hyperplastic parathyroid cells. |
| abstractGer |
SUMMARY: 22-oxa-calcitriol (OCT), a vitamin D analogue, suppresses parathyroid hormone (PTH) secretion and has less calcaemic activity than 1,25-dihydroxyvitamin D3 [1,25(OH)2D3] in vivo. In this study, we evaluated the effect of OCT on PTH secretion in vitro using human hyperplastic parathyroid tissue obtained during surgery for advanced renal hyperparathyroidism and normal bovine parathyroid glands to compare the effects of 1,25(OH)2D3. 22-oxa-calcitriol suppressed PTH secretion by nodular hyperplastic parathyroid tissue and normal bovine tissue in a dose dependent manner, the same as 1,25(OH)2D3. We showed the additive effect of extracellular calcium level on suppression of PTH secretion by OCT and 1,25(OH)2D3. These results suggest that OCT suppresses PTH secretion, the same as 1,25(OH)2D3 not only in normal parathyroid cells but also on hyperplastic parathyroid cells. |
| abstract_unstemmed |
SUMMARY: 22-oxa-calcitriol (OCT), a vitamin D analogue, suppresses parathyroid hormone (PTH) secretion and has less calcaemic activity than 1,25-dihydroxyvitamin D3 [1,25(OH)2D3] in vivo. In this study, we evaluated the effect of OCT on PTH secretion in vitro using human hyperplastic parathyroid tissue obtained during surgery for advanced renal hyperparathyroidism and normal bovine parathyroid glands to compare the effects of 1,25(OH)2D3. 22-oxa-calcitriol suppressed PTH secretion by nodular hyperplastic parathyroid tissue and normal bovine tissue in a dose dependent manner, the same as 1,25(OH)2D3. We showed the additive effect of extracellular calcium level on suppression of PTH secretion by OCT and 1,25(OH)2D3. These results suggest that OCT suppresses PTH secretion, the same as 1,25(OH)2D3 not only in normal parathyroid cells but also on hyperplastic parathyroid cells. |
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| title_short |
In vitro suppression of parathyroid hormone secretion by 22-oxa-calcitriol in human parathyroid hyperplasia due to uraermia |
| url |
http://dx.doi.org/10.1046/j.1440-1797.1998.d01-28.x |
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TOMINAGA, Yoshihiro ICHIKAWA, Fumihiko UCHIDA, Kazuharu TAKEZAWA, Jun-ichi TSUCHIYA, Takeshi KUBODERA, Noboru TAKAGI, Hiroshi |
| author2Str |
TOMINAGA, Yoshihiro ICHIKAWA, Fumihiko UCHIDA, Kazuharu TAKEZAWA, Jun-ichi TSUCHIYA, Takeshi KUBODERA, Noboru TAKAGI, Hiroshi |
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10.1046/j.1440-1797.1998.d01-28.x |
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