Treatment of IgA nephropathy: an overview
Summary: The results of proposed approaches to the treatment of IgA nephropathy are discussed, stressing the difficulty of their correct evaluation due to the variable evolution of the disease. There is no convincing evidence that supports a beneficial effect for many of the therapeutical remedies w...
Ausführliche Beschreibung
Gespeichert in:
| Autor*in: |
D'AMICO, Giuseppe [verfasserIn] |
|---|
| Format: |
E-Artikel |
|---|
| Erschienen: |
Oxford, UK: Blackwell Publishing Ltd ; 1997 |
|---|
| Schlagwörter: |
|---|
| Umfang: |
Online-Ressource |
|---|
| Reproduktion: |
2007 ; Blackwell Publishing Journal Backfiles 1879-2005 |
|---|---|
| Übergeordnetes Werk: |
In: Nephrology - Oxford [u.a.] : Wiley-Blackwell, 1995, 3(1997), Seite 0 |
| Übergeordnetes Werk: |
volume:3 ; year:1997 ; pages:0 |
| Links: |
|---|
| DOI / URN: |
10.1111/j.1440-1797.1997.tb00291.x |
|---|
| Katalog-ID: |
NLEJ243518080 |
|---|
| LEADER | 01000caa a22002652 4500 | ||
|---|---|---|---|
| 001 | NLEJ243518080 | ||
| 003 | DE-627 | ||
| 005 | 20230505193247.0 | ||
| 007 | cr uuu---uuuuu | ||
| 008 | 120427s1997 xx |||||o 00| ||und c | ||
| 024 | 7 | |a 10.1111/j.1440-1797.1997.tb00291.x |2 doi | |
| 035 | |a (DE-627)NLEJ243518080 | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rakwb | ||
| 100 | 1 | |a D'AMICO, Giuseppe |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a Treatment of IgA nephropathy: an overview |
| 264 | 1 | |a Oxford, UK |b Blackwell Publishing Ltd |c 1997 | |
| 300 | |a Online-Ressource | ||
| 336 | |a nicht spezifiziert |b zzz |2 rdacontent | ||
| 337 | |a nicht spezifiziert |b z |2 rdamedia | ||
| 338 | |a nicht spezifiziert |b zu |2 rdacarrier | ||
| 520 | |a Summary: The results of proposed approaches to the treatment of IgA nephropathy are discussed, stressing the difficulty of their correct evaluation due to the variable evolution of the disease. There is no convincing evidence that supports a beneficial effect for many of the therapeutical remedies with the following exceptions: (i) steroids are effective in the rare patients with selective proteinuria in the nephrotic range and very mild lesions by light microscopy (minimal change nephropathy with IgA mesangial deposits). the use of steroids is useful, in association with cyclophosphamide, even in patients with morphological features of intraglomerular capillaritis (segmental necrotizing lesions) and/or extracapillary proliferation in more than 25% of glomeruli (independently of the presence of diffuse circumferential crescents and a rapidly progressive course). A controlled trial that is underway will attempt to establish whether steroids can be effective in retarding deterioration of renal function in other subgroups of patients at risk of progression; (ii) fish-oil, administered orally (12 g/day for 2 years), is beneficial in patients at risk of progression (marked proteinuria, moderately impaired renal function, arterial hypertension and morphological features of active disease); and (iii) long-term administration of angiotensin converting enzyme (ACE)-inhibitors, even in the absence of arterial hypertension, seem to slow the progression and reduce the protein loss in the same group of patients at risk. | ||
| 533 | |d 2007 |f Blackwell Publishing Journal Backfiles 1879-2005 |7 |2007|||||||||| | ||
| 650 | 4 | |a ACE-inhibitors | |
| 773 | 0 | 8 | |i In |t Nephrology |d Oxford [u.a.] : Wiley-Blackwell, 1995 |g 3(1997), Seite 0 |h Online-Ressource |w (DE-627)NLEJ243925859 |w (DE-600)2008235-6 |x 1440-1797 |7 nnns |
| 773 | 1 | 8 | |g volume:3 |g year:1997 |g pages:0 |
| 856 | 4 | 0 | |u http://dx.doi.org/10.1111/j.1440-1797.1997.tb00291.x |q text/html |x Verlag |z Deutschlandweit zugänglich |3 Volltext |
| 912 | |a GBV_USEFLAG_U | ||
| 912 | |a ZDB-1-DJB | ||
| 912 | |a GBV_NL_ARTICLE | ||
| 951 | |a AR | ||
| 952 | |d 3 |j 1997 |h 0 | ||
| author_variant |
g d gd |
|---|---|
| matchkey_str |
article:14401797:1997----::ramnoiaehoah |
| hierarchy_sort_str |
1997 |
| publishDate |
1997 |
| allfields |
10.1111/j.1440-1797.1997.tb00291.x doi (DE-627)NLEJ243518080 DE-627 ger DE-627 rakwb D'AMICO, Giuseppe verfasserin aut Treatment of IgA nephropathy: an overview Oxford, UK Blackwell Publishing Ltd 1997 Online-Ressource nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Summary: The results of proposed approaches to the treatment of IgA nephropathy are discussed, stressing the difficulty of their correct evaluation due to the variable evolution of the disease. There is no convincing evidence that supports a beneficial effect for many of the therapeutical remedies with the following exceptions: (i) steroids are effective in the rare patients with selective proteinuria in the nephrotic range and very mild lesions by light microscopy (minimal change nephropathy with IgA mesangial deposits). the use of steroids is useful, in association with cyclophosphamide, even in patients with morphological features of intraglomerular capillaritis (segmental necrotizing lesions) and/or extracapillary proliferation in more than 25% of glomeruli (independently of the presence of diffuse circumferential crescents and a rapidly progressive course). A controlled trial that is underway will attempt to establish whether steroids can be effective in retarding deterioration of renal function in other subgroups of patients at risk of progression; (ii) fish-oil, administered orally (12 g/day for 2 years), is beneficial in patients at risk of progression (marked proteinuria, moderately impaired renal function, arterial hypertension and morphological features of active disease); and (iii) long-term administration of angiotensin converting enzyme (ACE)-inhibitors, even in the absence of arterial hypertension, seem to slow the progression and reduce the protein loss in the same group of patients at risk. 2007 Blackwell Publishing Journal Backfiles 1879-2005 |2007|||||||||| ACE-inhibitors In Nephrology Oxford [u.a.] : Wiley-Blackwell, 1995 3(1997), Seite 0 Online-Ressource (DE-627)NLEJ243925859 (DE-600)2008235-6 1440-1797 nnns volume:3 year:1997 pages:0 http://dx.doi.org/10.1111/j.1440-1797.1997.tb00291.x text/html Verlag Deutschlandweit zugänglich Volltext GBV_USEFLAG_U ZDB-1-DJB GBV_NL_ARTICLE AR 3 1997 0 |
| spelling |
10.1111/j.1440-1797.1997.tb00291.x doi (DE-627)NLEJ243518080 DE-627 ger DE-627 rakwb D'AMICO, Giuseppe verfasserin aut Treatment of IgA nephropathy: an overview Oxford, UK Blackwell Publishing Ltd 1997 Online-Ressource nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Summary: The results of proposed approaches to the treatment of IgA nephropathy are discussed, stressing the difficulty of their correct evaluation due to the variable evolution of the disease. There is no convincing evidence that supports a beneficial effect for many of the therapeutical remedies with the following exceptions: (i) steroids are effective in the rare patients with selective proteinuria in the nephrotic range and very mild lesions by light microscopy (minimal change nephropathy with IgA mesangial deposits). the use of steroids is useful, in association with cyclophosphamide, even in patients with morphological features of intraglomerular capillaritis (segmental necrotizing lesions) and/or extracapillary proliferation in more than 25% of glomeruli (independently of the presence of diffuse circumferential crescents and a rapidly progressive course). A controlled trial that is underway will attempt to establish whether steroids can be effective in retarding deterioration of renal function in other subgroups of patients at risk of progression; (ii) fish-oil, administered orally (12 g/day for 2 years), is beneficial in patients at risk of progression (marked proteinuria, moderately impaired renal function, arterial hypertension and morphological features of active disease); and (iii) long-term administration of angiotensin converting enzyme (ACE)-inhibitors, even in the absence of arterial hypertension, seem to slow the progression and reduce the protein loss in the same group of patients at risk. 2007 Blackwell Publishing Journal Backfiles 1879-2005 |2007|||||||||| ACE-inhibitors In Nephrology Oxford [u.a.] : Wiley-Blackwell, 1995 3(1997), Seite 0 Online-Ressource (DE-627)NLEJ243925859 (DE-600)2008235-6 1440-1797 nnns volume:3 year:1997 pages:0 http://dx.doi.org/10.1111/j.1440-1797.1997.tb00291.x text/html Verlag Deutschlandweit zugänglich Volltext GBV_USEFLAG_U ZDB-1-DJB GBV_NL_ARTICLE AR 3 1997 0 |
| allfields_unstemmed |
10.1111/j.1440-1797.1997.tb00291.x doi (DE-627)NLEJ243518080 DE-627 ger DE-627 rakwb D'AMICO, Giuseppe verfasserin aut Treatment of IgA nephropathy: an overview Oxford, UK Blackwell Publishing Ltd 1997 Online-Ressource nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Summary: The results of proposed approaches to the treatment of IgA nephropathy are discussed, stressing the difficulty of their correct evaluation due to the variable evolution of the disease. There is no convincing evidence that supports a beneficial effect for many of the therapeutical remedies with the following exceptions: (i) steroids are effective in the rare patients with selective proteinuria in the nephrotic range and very mild lesions by light microscopy (minimal change nephropathy with IgA mesangial deposits). the use of steroids is useful, in association with cyclophosphamide, even in patients with morphological features of intraglomerular capillaritis (segmental necrotizing lesions) and/or extracapillary proliferation in more than 25% of glomeruli (independently of the presence of diffuse circumferential crescents and a rapidly progressive course). A controlled trial that is underway will attempt to establish whether steroids can be effective in retarding deterioration of renal function in other subgroups of patients at risk of progression; (ii) fish-oil, administered orally (12 g/day for 2 years), is beneficial in patients at risk of progression (marked proteinuria, moderately impaired renal function, arterial hypertension and morphological features of active disease); and (iii) long-term administration of angiotensin converting enzyme (ACE)-inhibitors, even in the absence of arterial hypertension, seem to slow the progression and reduce the protein loss in the same group of patients at risk. 2007 Blackwell Publishing Journal Backfiles 1879-2005 |2007|||||||||| ACE-inhibitors In Nephrology Oxford [u.a.] : Wiley-Blackwell, 1995 3(1997), Seite 0 Online-Ressource (DE-627)NLEJ243925859 (DE-600)2008235-6 1440-1797 nnns volume:3 year:1997 pages:0 http://dx.doi.org/10.1111/j.1440-1797.1997.tb00291.x text/html Verlag Deutschlandweit zugänglich Volltext GBV_USEFLAG_U ZDB-1-DJB GBV_NL_ARTICLE AR 3 1997 0 |
| allfieldsGer |
10.1111/j.1440-1797.1997.tb00291.x doi (DE-627)NLEJ243518080 DE-627 ger DE-627 rakwb D'AMICO, Giuseppe verfasserin aut Treatment of IgA nephropathy: an overview Oxford, UK Blackwell Publishing Ltd 1997 Online-Ressource nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Summary: The results of proposed approaches to the treatment of IgA nephropathy are discussed, stressing the difficulty of their correct evaluation due to the variable evolution of the disease. There is no convincing evidence that supports a beneficial effect for many of the therapeutical remedies with the following exceptions: (i) steroids are effective in the rare patients with selective proteinuria in the nephrotic range and very mild lesions by light microscopy (minimal change nephropathy with IgA mesangial deposits). the use of steroids is useful, in association with cyclophosphamide, even in patients with morphological features of intraglomerular capillaritis (segmental necrotizing lesions) and/or extracapillary proliferation in more than 25% of glomeruli (independently of the presence of diffuse circumferential crescents and a rapidly progressive course). A controlled trial that is underway will attempt to establish whether steroids can be effective in retarding deterioration of renal function in other subgroups of patients at risk of progression; (ii) fish-oil, administered orally (12 g/day for 2 years), is beneficial in patients at risk of progression (marked proteinuria, moderately impaired renal function, arterial hypertension and morphological features of active disease); and (iii) long-term administration of angiotensin converting enzyme (ACE)-inhibitors, even in the absence of arterial hypertension, seem to slow the progression and reduce the protein loss in the same group of patients at risk. 2007 Blackwell Publishing Journal Backfiles 1879-2005 |2007|||||||||| ACE-inhibitors In Nephrology Oxford [u.a.] : Wiley-Blackwell, 1995 3(1997), Seite 0 Online-Ressource (DE-627)NLEJ243925859 (DE-600)2008235-6 1440-1797 nnns volume:3 year:1997 pages:0 http://dx.doi.org/10.1111/j.1440-1797.1997.tb00291.x text/html Verlag Deutschlandweit zugänglich Volltext GBV_USEFLAG_U ZDB-1-DJB GBV_NL_ARTICLE AR 3 1997 0 |
| allfieldsSound |
10.1111/j.1440-1797.1997.tb00291.x doi (DE-627)NLEJ243518080 DE-627 ger DE-627 rakwb D'AMICO, Giuseppe verfasserin aut Treatment of IgA nephropathy: an overview Oxford, UK Blackwell Publishing Ltd 1997 Online-Ressource nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Summary: The results of proposed approaches to the treatment of IgA nephropathy are discussed, stressing the difficulty of their correct evaluation due to the variable evolution of the disease. There is no convincing evidence that supports a beneficial effect for many of the therapeutical remedies with the following exceptions: (i) steroids are effective in the rare patients with selective proteinuria in the nephrotic range and very mild lesions by light microscopy (minimal change nephropathy with IgA mesangial deposits). the use of steroids is useful, in association with cyclophosphamide, even in patients with morphological features of intraglomerular capillaritis (segmental necrotizing lesions) and/or extracapillary proliferation in more than 25% of glomeruli (independently of the presence of diffuse circumferential crescents and a rapidly progressive course). A controlled trial that is underway will attempt to establish whether steroids can be effective in retarding deterioration of renal function in other subgroups of patients at risk of progression; (ii) fish-oil, administered orally (12 g/day for 2 years), is beneficial in patients at risk of progression (marked proteinuria, moderately impaired renal function, arterial hypertension and morphological features of active disease); and (iii) long-term administration of angiotensin converting enzyme (ACE)-inhibitors, even in the absence of arterial hypertension, seem to slow the progression and reduce the protein loss in the same group of patients at risk. 2007 Blackwell Publishing Journal Backfiles 1879-2005 |2007|||||||||| ACE-inhibitors In Nephrology Oxford [u.a.] : Wiley-Blackwell, 1995 3(1997), Seite 0 Online-Ressource (DE-627)NLEJ243925859 (DE-600)2008235-6 1440-1797 nnns volume:3 year:1997 pages:0 http://dx.doi.org/10.1111/j.1440-1797.1997.tb00291.x text/html Verlag Deutschlandweit zugänglich Volltext GBV_USEFLAG_U ZDB-1-DJB GBV_NL_ARTICLE AR 3 1997 0 |
| source |
In Nephrology 3(1997), Seite 0 volume:3 year:1997 pages:0 |
| sourceStr |
In Nephrology 3(1997), Seite 0 volume:3 year:1997 pages:0 |
| format_phy_str_mv |
Article |
| institution |
findex.gbv.de |
| topic_facet |
ACE-inhibitors |
| isfreeaccess_bool |
false |
| container_title |
Nephrology |
| authorswithroles_txt_mv |
D'AMICO, Giuseppe @@aut@@ |
| publishDateDaySort_date |
1997-01-01T00:00:00Z |
| hierarchy_top_id |
NLEJ243925859 |
| id |
NLEJ243518080 |
| fullrecord |
<?xml version="1.0" encoding="UTF-8"?><collection xmlns="http://www.loc.gov/MARC21/slim"><record><leader>01000caa a22002652 4500</leader><controlfield tag="001">NLEJ243518080</controlfield><controlfield tag="003">DE-627</controlfield><controlfield tag="005">20230505193247.0</controlfield><controlfield tag="007">cr uuu---uuuuu</controlfield><controlfield tag="008">120427s1997 xx |||||o 00| ||und c</controlfield><datafield tag="024" ind1="7" ind2=" "><subfield code="a">10.1111/j.1440-1797.1997.tb00291.x</subfield><subfield code="2">doi</subfield></datafield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(DE-627)NLEJ243518080</subfield></datafield><datafield tag="040" ind1=" " ind2=" "><subfield code="a">DE-627</subfield><subfield code="b">ger</subfield><subfield code="c">DE-627</subfield><subfield code="e">rakwb</subfield></datafield><datafield tag="100" ind1="1" ind2=" "><subfield code="a">D'AMICO, Giuseppe</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="245" ind1="1" ind2="0"><subfield code="a">Treatment of IgA nephropathy: an overview</subfield></datafield><datafield tag="264" ind1=" " ind2="1"><subfield code="a">Oxford, UK</subfield><subfield code="b">Blackwell Publishing Ltd</subfield><subfield code="c">1997</subfield></datafield><datafield tag="300" ind1=" " ind2=" "><subfield code="a">Online-Ressource</subfield></datafield><datafield tag="336" ind1=" " ind2=" "><subfield code="a">nicht spezifiziert</subfield><subfield code="b">zzz</subfield><subfield code="2">rdacontent</subfield></datafield><datafield tag="337" ind1=" " ind2=" "><subfield code="a">nicht spezifiziert</subfield><subfield code="b">z</subfield><subfield code="2">rdamedia</subfield></datafield><datafield tag="338" ind1=" " ind2=" "><subfield code="a">nicht spezifiziert</subfield><subfield code="b">zu</subfield><subfield code="2">rdacarrier</subfield></datafield><datafield tag="520" ind1=" " ind2=" "><subfield code="a">Summary: The results of proposed approaches to the treatment of IgA nephropathy are discussed, stressing the difficulty of their correct evaluation due to the variable evolution of the disease. There is no convincing evidence that supports a beneficial effect for many of the therapeutical remedies with the following exceptions: (i) steroids are effective in the rare patients with selective proteinuria in the nephrotic range and very mild lesions by light microscopy (minimal change nephropathy with IgA mesangial deposits). the use of steroids is useful, in association with cyclophosphamide, even in patients with morphological features of intraglomerular capillaritis (segmental necrotizing lesions) and/or extracapillary proliferation in more than 25% of glomeruli (independently of the presence of diffuse circumferential crescents and a rapidly progressive course). A controlled trial that is underway will attempt to establish whether steroids can be effective in retarding deterioration of renal function in other subgroups of patients at risk of progression; (ii) fish-oil, administered orally (12 g/day for 2 years), is beneficial in patients at risk of progression (marked proteinuria, moderately impaired renal function, arterial hypertension and morphological features of active disease); and (iii) long-term administration of angiotensin converting enzyme (ACE)-inhibitors, even in the absence of arterial hypertension, seem to slow the progression and reduce the protein loss in the same group of patients at risk.</subfield></datafield><datafield tag="533" ind1=" " ind2=" "><subfield code="d">2007</subfield><subfield code="f">Blackwell Publishing Journal Backfiles 1879-2005</subfield><subfield code="7">|2007||||||||||</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">ACE-inhibitors</subfield></datafield><datafield tag="773" ind1="0" ind2="8"><subfield code="i">In</subfield><subfield code="t">Nephrology</subfield><subfield code="d">Oxford [u.a.] : Wiley-Blackwell, 1995</subfield><subfield code="g">3(1997), Seite 0</subfield><subfield code="h">Online-Ressource</subfield><subfield code="w">(DE-627)NLEJ243925859</subfield><subfield code="w">(DE-600)2008235-6</subfield><subfield code="x">1440-1797</subfield><subfield code="7">nnns</subfield></datafield><datafield tag="773" ind1="1" ind2="8"><subfield code="g">volume:3</subfield><subfield code="g">year:1997</subfield><subfield code="g">pages:0</subfield></datafield><datafield tag="856" ind1="4" ind2="0"><subfield code="u">http://dx.doi.org/10.1111/j.1440-1797.1997.tb00291.x</subfield><subfield code="q">text/html</subfield><subfield code="x">Verlag</subfield><subfield code="z">Deutschlandweit zugänglich</subfield><subfield code="3">Volltext</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_USEFLAG_U</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">ZDB-1-DJB</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_NL_ARTICLE</subfield></datafield><datafield tag="951" ind1=" " ind2=" "><subfield code="a">AR</subfield></datafield><datafield tag="952" ind1=" " ind2=" "><subfield code="d">3</subfield><subfield code="j">1997</subfield><subfield code="h">0</subfield></datafield></record></collection>
|
| series2 |
Blackwell Publishing Journal Backfiles 1879-2005 |
| author |
D'AMICO, Giuseppe |
| spellingShingle |
D'AMICO, Giuseppe misc ACE-inhibitors Treatment of IgA nephropathy: an overview |
| authorStr |
D'AMICO, Giuseppe |
| ppnlink_with_tag_str_mv |
@@773@@(DE-627)NLEJ243925859 |
| format |
electronic Article |
| delete_txt_mv |
keep |
| author_role |
aut |
| collection |
NL |
| publishPlace |
Oxford, UK |
| remote_str |
true |
| illustrated |
Not Illustrated |
| issn |
1440-1797 |
| topic_title |
Treatment of IgA nephropathy: an overview ACE-inhibitors |
| publisher |
Blackwell Publishing Ltd |
| publisherStr |
Blackwell Publishing Ltd |
| topic |
misc ACE-inhibitors |
| topic_unstemmed |
misc ACE-inhibitors |
| topic_browse |
misc ACE-inhibitors |
| format_facet |
Elektronische Aufsätze Aufsätze Elektronische Ressource |
| format_main_str_mv |
Text Zeitschrift/Artikel |
| carriertype_str_mv |
zu |
| hierarchy_parent_title |
Nephrology |
| hierarchy_parent_id |
NLEJ243925859 |
| hierarchy_top_title |
Nephrology |
| isfreeaccess_txt |
false |
| familylinks_str_mv |
(DE-627)NLEJ243925859 (DE-600)2008235-6 |
| title |
Treatment of IgA nephropathy: an overview |
| ctrlnum |
(DE-627)NLEJ243518080 |
| title_full |
Treatment of IgA nephropathy: an overview |
| author_sort |
D'AMICO, Giuseppe |
| journal |
Nephrology |
| journalStr |
Nephrology |
| isOA_bool |
false |
| recordtype |
marc |
| publishDateSort |
1997 |
| contenttype_str_mv |
zzz |
| container_start_page |
0 |
| author_browse |
D'AMICO, Giuseppe |
| container_volume |
3 |
| physical |
Online-Ressource |
| format_se |
Elektronische Aufsätze |
| author-letter |
D'AMICO, Giuseppe |
| doi_str_mv |
10.1111/j.1440-1797.1997.tb00291.x |
| title_sort |
treatment of iga nephropathy: an overview |
| title_auth |
Treatment of IgA nephropathy: an overview |
| abstract |
Summary: The results of proposed approaches to the treatment of IgA nephropathy are discussed, stressing the difficulty of their correct evaluation due to the variable evolution of the disease. There is no convincing evidence that supports a beneficial effect for many of the therapeutical remedies with the following exceptions: (i) steroids are effective in the rare patients with selective proteinuria in the nephrotic range and very mild lesions by light microscopy (minimal change nephropathy with IgA mesangial deposits). the use of steroids is useful, in association with cyclophosphamide, even in patients with morphological features of intraglomerular capillaritis (segmental necrotizing lesions) and/or extracapillary proliferation in more than 25% of glomeruli (independently of the presence of diffuse circumferential crescents and a rapidly progressive course). A controlled trial that is underway will attempt to establish whether steroids can be effective in retarding deterioration of renal function in other subgroups of patients at risk of progression; (ii) fish-oil, administered orally (12 g/day for 2 years), is beneficial in patients at risk of progression (marked proteinuria, moderately impaired renal function, arterial hypertension and morphological features of active disease); and (iii) long-term administration of angiotensin converting enzyme (ACE)-inhibitors, even in the absence of arterial hypertension, seem to slow the progression and reduce the protein loss in the same group of patients at risk. |
| abstractGer |
Summary: The results of proposed approaches to the treatment of IgA nephropathy are discussed, stressing the difficulty of their correct evaluation due to the variable evolution of the disease. There is no convincing evidence that supports a beneficial effect for many of the therapeutical remedies with the following exceptions: (i) steroids are effective in the rare patients with selective proteinuria in the nephrotic range and very mild lesions by light microscopy (minimal change nephropathy with IgA mesangial deposits). the use of steroids is useful, in association with cyclophosphamide, even in patients with morphological features of intraglomerular capillaritis (segmental necrotizing lesions) and/or extracapillary proliferation in more than 25% of glomeruli (independently of the presence of diffuse circumferential crescents and a rapidly progressive course). A controlled trial that is underway will attempt to establish whether steroids can be effective in retarding deterioration of renal function in other subgroups of patients at risk of progression; (ii) fish-oil, administered orally (12 g/day for 2 years), is beneficial in patients at risk of progression (marked proteinuria, moderately impaired renal function, arterial hypertension and morphological features of active disease); and (iii) long-term administration of angiotensin converting enzyme (ACE)-inhibitors, even in the absence of arterial hypertension, seem to slow the progression and reduce the protein loss in the same group of patients at risk. |
| abstract_unstemmed |
Summary: The results of proposed approaches to the treatment of IgA nephropathy are discussed, stressing the difficulty of their correct evaluation due to the variable evolution of the disease. There is no convincing evidence that supports a beneficial effect for many of the therapeutical remedies with the following exceptions: (i) steroids are effective in the rare patients with selective proteinuria in the nephrotic range and very mild lesions by light microscopy (minimal change nephropathy with IgA mesangial deposits). the use of steroids is useful, in association with cyclophosphamide, even in patients with morphological features of intraglomerular capillaritis (segmental necrotizing lesions) and/or extracapillary proliferation in more than 25% of glomeruli (independently of the presence of diffuse circumferential crescents and a rapidly progressive course). A controlled trial that is underway will attempt to establish whether steroids can be effective in retarding deterioration of renal function in other subgroups of patients at risk of progression; (ii) fish-oil, administered orally (12 g/day for 2 years), is beneficial in patients at risk of progression (marked proteinuria, moderately impaired renal function, arterial hypertension and morphological features of active disease); and (iii) long-term administration of angiotensin converting enzyme (ACE)-inhibitors, even in the absence of arterial hypertension, seem to slow the progression and reduce the protein loss in the same group of patients at risk. |
| collection_details |
GBV_USEFLAG_U ZDB-1-DJB GBV_NL_ARTICLE |
| title_short |
Treatment of IgA nephropathy: an overview |
| url |
http://dx.doi.org/10.1111/j.1440-1797.1997.tb00291.x |
| remote_bool |
true |
| ppnlink |
NLEJ243925859 |
| mediatype_str_mv |
z |
| isOA_txt |
false |
| hochschulschrift_bool |
false |
| doi_str |
10.1111/j.1440-1797.1997.tb00291.x |
| up_date |
2024-07-06T05:42:26.413Z |
| _version_ |
1803807145500606464 |
| fullrecord_marcxml |
<?xml version="1.0" encoding="UTF-8"?><collection xmlns="http://www.loc.gov/MARC21/slim"><record><leader>01000caa a22002652 4500</leader><controlfield tag="001">NLEJ243518080</controlfield><controlfield tag="003">DE-627</controlfield><controlfield tag="005">20230505193247.0</controlfield><controlfield tag="007">cr uuu---uuuuu</controlfield><controlfield tag="008">120427s1997 xx |||||o 00| ||und c</controlfield><datafield tag="024" ind1="7" ind2=" "><subfield code="a">10.1111/j.1440-1797.1997.tb00291.x</subfield><subfield code="2">doi</subfield></datafield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(DE-627)NLEJ243518080</subfield></datafield><datafield tag="040" ind1=" " ind2=" "><subfield code="a">DE-627</subfield><subfield code="b">ger</subfield><subfield code="c">DE-627</subfield><subfield code="e">rakwb</subfield></datafield><datafield tag="100" ind1="1" ind2=" "><subfield code="a">D'AMICO, Giuseppe</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="245" ind1="1" ind2="0"><subfield code="a">Treatment of IgA nephropathy: an overview</subfield></datafield><datafield tag="264" ind1=" " ind2="1"><subfield code="a">Oxford, UK</subfield><subfield code="b">Blackwell Publishing Ltd</subfield><subfield code="c">1997</subfield></datafield><datafield tag="300" ind1=" " ind2=" "><subfield code="a">Online-Ressource</subfield></datafield><datafield tag="336" ind1=" " ind2=" "><subfield code="a">nicht spezifiziert</subfield><subfield code="b">zzz</subfield><subfield code="2">rdacontent</subfield></datafield><datafield tag="337" ind1=" " ind2=" "><subfield code="a">nicht spezifiziert</subfield><subfield code="b">z</subfield><subfield code="2">rdamedia</subfield></datafield><datafield tag="338" ind1=" " ind2=" "><subfield code="a">nicht spezifiziert</subfield><subfield code="b">zu</subfield><subfield code="2">rdacarrier</subfield></datafield><datafield tag="520" ind1=" " ind2=" "><subfield code="a">Summary: The results of proposed approaches to the treatment of IgA nephropathy are discussed, stressing the difficulty of their correct evaluation due to the variable evolution of the disease. There is no convincing evidence that supports a beneficial effect for many of the therapeutical remedies with the following exceptions: (i) steroids are effective in the rare patients with selective proteinuria in the nephrotic range and very mild lesions by light microscopy (minimal change nephropathy with IgA mesangial deposits). the use of steroids is useful, in association with cyclophosphamide, even in patients with morphological features of intraglomerular capillaritis (segmental necrotizing lesions) and/or extracapillary proliferation in more than 25% of glomeruli (independently of the presence of diffuse circumferential crescents and a rapidly progressive course). A controlled trial that is underway will attempt to establish whether steroids can be effective in retarding deterioration of renal function in other subgroups of patients at risk of progression; (ii) fish-oil, administered orally (12 g/day for 2 years), is beneficial in patients at risk of progression (marked proteinuria, moderately impaired renal function, arterial hypertension and morphological features of active disease); and (iii) long-term administration of angiotensin converting enzyme (ACE)-inhibitors, even in the absence of arterial hypertension, seem to slow the progression and reduce the protein loss in the same group of patients at risk.</subfield></datafield><datafield tag="533" ind1=" " ind2=" "><subfield code="d">2007</subfield><subfield code="f">Blackwell Publishing Journal Backfiles 1879-2005</subfield><subfield code="7">|2007||||||||||</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">ACE-inhibitors</subfield></datafield><datafield tag="773" ind1="0" ind2="8"><subfield code="i">In</subfield><subfield code="t">Nephrology</subfield><subfield code="d">Oxford [u.a.] : Wiley-Blackwell, 1995</subfield><subfield code="g">3(1997), Seite 0</subfield><subfield code="h">Online-Ressource</subfield><subfield code="w">(DE-627)NLEJ243925859</subfield><subfield code="w">(DE-600)2008235-6</subfield><subfield code="x">1440-1797</subfield><subfield code="7">nnns</subfield></datafield><datafield tag="773" ind1="1" ind2="8"><subfield code="g">volume:3</subfield><subfield code="g">year:1997</subfield><subfield code="g">pages:0</subfield></datafield><datafield tag="856" ind1="4" ind2="0"><subfield code="u">http://dx.doi.org/10.1111/j.1440-1797.1997.tb00291.x</subfield><subfield code="q">text/html</subfield><subfield code="x">Verlag</subfield><subfield code="z">Deutschlandweit zugänglich</subfield><subfield code="3">Volltext</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_USEFLAG_U</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">ZDB-1-DJB</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_NL_ARTICLE</subfield></datafield><datafield tag="951" ind1=" " ind2=" "><subfield code="a">AR</subfield></datafield><datafield tag="952" ind1=" " ind2=" "><subfield code="d">3</subfield><subfield code="j">1997</subfield><subfield code="h">0</subfield></datafield></record></collection>
|
| score |
7.4016895 |