Cardiac troponin I and beta 2 microglobulin as risk factors for early-onset atherosclerosis in patients on haemodialysis

Aim: To investigate the associations of different risk factors with carotid artery intima-media thickness (C-IMT) in non-diabetic haemodialysis (HD) patients who had no clinical evidence of atherosclerosis.Methods: Seventy-two HD patients (43 men, 29 women; mean age: 34.5 ± 10.6 years; mean time o...
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Autor*in:	ZUMRUTDAL, AYSEGUL [verfasserIn] SEZER, SIREN [verfasserIn] DEMIRCAN, SENOL [verfasserIn] SEYDAOGLU, GULSAH OZDEMIR, F NURHAN HABERAL, MEHMET

Format:	E-Artikel

Erschienen:	Melbourne, Australia: Blackwell Science Pty ; 2005

Schlagwörter:	beta 2 microglobulin

Umfang:	Online-Ressource

Reproduktion:	2005 ; Blackwell Publishing Journal Backfiles 1879-2005
Übergeordnetes Werk:	In: Nephrology - Oxford [u.a.] : Wiley-Blackwell, 1995, 10(2005), 5, Seite 0
Übergeordnetes Werk:	volume:10 ; year:2005 ; number:5 ; pages:0

Links:	Volltext

DOI / URN:	10.1111/j.1440-1797.2005.00475.x

Katalog-ID:	NLEJ243520549

Internformat


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245	1	0	\|a Cardiac troponin I and beta 2 microglobulin as risk factors for early-onset atherosclerosis in patients on haemodialysis
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520			\|a Aim: To investigate the associations of different risk factors with carotid artery intima-media thickness (C-IMT) in non-diabetic haemodialysis (HD) patients who had no clinical evidence of atherosclerosis.Methods: Seventy-two HD patients (43 men, 29 women; mean age: 34.5 ± 10.6 years; mean time on HD: 47.9 ± 40.0 months) and 40 age- and sex-matched healthy controls (26 men, 14 women; mean age: 35.5 ± 7.1 years) participated in the study. The relationship between C-IMT and haematocrit-corrected erythrocyte sedimentation rate (Hct-corrected ESR), beta 2 microglobulin (beta2M) and serum cardiac troponin I (cTnI) levels beyond C-reactive protein (CRP), lipid profile and lipoprotein(a), fibrinogen, homocysteine and left ventricular hypertrophy (LVH) were examined.Results: Mean C-IMT of the HD patients was significantly greater than that of the control subjects (0.59 ± 0.06 vs 0.53 ± 0.07 mm, P = 0.002). C-IMT of patients was positively correlated with age (r = 0.33), body mass index (r = 0.40), Hct-corrected ESR (r = 0.37), CRP (r = 0.34), beta2M (r = 0.34), cTnI (r = 0.26), triglyceride (r = 0.26) and fibrinogen (r = 0.28) levels (P < 0.05 for all). The mean C-IMT was significantly greater in patients with LVH than it was in those without LVH (P = 0.004). In multivariate regression analysis, age (P = 0.02), beta2M (P = 0.001), log-transformed CRP (P = 0.03) and LVH (P = 0.01) were independently related with C-IMT.Conclusion: Besides well-known cardiovascular (CV) risk factors, cTnI and beta2M were related with C-IMT in that they may have important roles in early-onset atherosclerosis in this high-risk population.
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allfields	10.1111/j.1440-1797.2005.00475.x doi (DE-627)NLEJ243520549 DE-627 ger DE-627 rakwb ZUMRUTDAL, AYSEGUL verfasserin aut Cardiac troponin I and beta 2 microglobulin as risk factors for early-onset atherosclerosis in patients on haemodialysis Melbourne, Australia Blackwell Science Pty 2005 Online-Ressource nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Aim: To investigate the associations of different risk factors with carotid artery intima-media thickness (C-IMT) in non-diabetic haemodialysis (HD) patients who had no clinical evidence of atherosclerosis.Methods: Seventy-two HD patients (43 men, 29 women; mean age: 34.5 ± 10.6 years; mean time on HD: 47.9 ± 40.0 months) and 40 age- and sex-matched healthy controls (26 men, 14 women; mean age: 35.5 ± 7.1 years) participated in the study. The relationship between C-IMT and haematocrit-corrected erythrocyte sedimentation rate (Hct-corrected ESR), beta 2 microglobulin (beta2M) and serum cardiac troponin I (cTnI) levels beyond C-reactive protein (CRP), lipid profile and lipoprotein(a), fibrinogen, homocysteine and left ventricular hypertrophy (LVH) were examined.Results: Mean C-IMT of the HD patients was significantly greater than that of the control subjects (0.59 ± 0.06 vs 0.53 ± 0.07 mm, P = 0.002). C-IMT of patients was positively correlated with age (r = 0.33), body mass index (r = 0.40), Hct-corrected ESR (r = 0.37), CRP (r = 0.34), beta2M (r = 0.34), cTnI (r = 0.26), triglyceride (r = 0.26) and fibrinogen (r = 0.28) levels (P < 0.05 for all). The mean C-IMT was significantly greater in patients with LVH than it was in those without LVH (P = 0.004). In multivariate regression analysis, age (P = 0.02), beta2M (P = 0.001), log-transformed CRP (P = 0.03) and LVH (P = 0.01) were independently related with C-IMT.Conclusion: Besides well-known cardiovascular (CV) risk factors, cTnI and beta2M were related with C-IMT in that they may have important roles in early-onset atherosclerosis in this high-risk population. 2005 Blackwell Publishing Journal Backfiles 1879-2005 \|2005\|\|\|\|\|\|\|\|\|\| beta 2 microglobulin SEZER, SIREN verfasserin aut DEMIRCAN, SENOL verfasserin aut SEYDAOGLU, GULSAH oth OZDEMIR, F NURHAN oth HABERAL, MEHMET oth In Nephrology Oxford [u.a.] : Wiley-Blackwell, 1995 10(2005), 5, Seite 0 Online-Ressource (DE-627)NLEJ243925859 (DE-600)2008235-6 1440-1797 nnns volume:10 year:2005 number:5 pages:0 http://dx.doi.org/10.1111/j.1440-1797.2005.00475.x text/html Verlag Deutschlandweit zugänglich Volltext GBV_USEFLAG_U ZDB-1-DJB GBV_NL_ARTICLE AR 10 2005 5 0
spelling	10.1111/j.1440-1797.2005.00475.x doi (DE-627)NLEJ243520549 DE-627 ger DE-627 rakwb ZUMRUTDAL, AYSEGUL verfasserin aut Cardiac troponin I and beta 2 microglobulin as risk factors for early-onset atherosclerosis in patients on haemodialysis Melbourne, Australia Blackwell Science Pty 2005 Online-Ressource nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Aim: To investigate the associations of different risk factors with carotid artery intima-media thickness (C-IMT) in non-diabetic haemodialysis (HD) patients who had no clinical evidence of atherosclerosis.Methods: Seventy-two HD patients (43 men, 29 women; mean age: 34.5 ± 10.6 years; mean time on HD: 47.9 ± 40.0 months) and 40 age- and sex-matched healthy controls (26 men, 14 women; mean age: 35.5 ± 7.1 years) participated in the study. The relationship between C-IMT and haematocrit-corrected erythrocyte sedimentation rate (Hct-corrected ESR), beta 2 microglobulin (beta2M) and serum cardiac troponin I (cTnI) levels beyond C-reactive protein (CRP), lipid profile and lipoprotein(a), fibrinogen, homocysteine and left ventricular hypertrophy (LVH) were examined.Results: Mean C-IMT of the HD patients was significantly greater than that of the control subjects (0.59 ± 0.06 vs 0.53 ± 0.07 mm, P = 0.002). C-IMT of patients was positively correlated with age (r = 0.33), body mass index (r = 0.40), Hct-corrected ESR (r = 0.37), CRP (r = 0.34), beta2M (r = 0.34), cTnI (r = 0.26), triglyceride (r = 0.26) and fibrinogen (r = 0.28) levels (P < 0.05 for all). The mean C-IMT was significantly greater in patients with LVH than it was in those without LVH (P = 0.004). In multivariate regression analysis, age (P = 0.02), beta2M (P = 0.001), log-transformed CRP (P = 0.03) and LVH (P = 0.01) were independently related with C-IMT.Conclusion: Besides well-known cardiovascular (CV) risk factors, cTnI and beta2M were related with C-IMT in that they may have important roles in early-onset atherosclerosis in this high-risk population. 2005 Blackwell Publishing Journal Backfiles 1879-2005 \|2005\|\|\|\|\|\|\|\|\|\| beta 2 microglobulin SEZER, SIREN verfasserin aut DEMIRCAN, SENOL verfasserin aut SEYDAOGLU, GULSAH oth OZDEMIR, F NURHAN oth HABERAL, MEHMET oth In Nephrology Oxford [u.a.] : Wiley-Blackwell, 1995 10(2005), 5, Seite 0 Online-Ressource (DE-627)NLEJ243925859 (DE-600)2008235-6 1440-1797 nnns volume:10 year:2005 number:5 pages:0 http://dx.doi.org/10.1111/j.1440-1797.2005.00475.x text/html Verlag Deutschlandweit zugänglich Volltext GBV_USEFLAG_U ZDB-1-DJB GBV_NL_ARTICLE AR 10 2005 5 0
allfields_unstemmed	10.1111/j.1440-1797.2005.00475.x doi (DE-627)NLEJ243520549 DE-627 ger DE-627 rakwb ZUMRUTDAL, AYSEGUL verfasserin aut Cardiac troponin I and beta 2 microglobulin as risk factors for early-onset atherosclerosis in patients on haemodialysis Melbourne, Australia Blackwell Science Pty 2005 Online-Ressource nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Aim: To investigate the associations of different risk factors with carotid artery intima-media thickness (C-IMT) in non-diabetic haemodialysis (HD) patients who had no clinical evidence of atherosclerosis.Methods: Seventy-two HD patients (43 men, 29 women; mean age: 34.5 ± 10.6 years; mean time on HD: 47.9 ± 40.0 months) and 40 age- and sex-matched healthy controls (26 men, 14 women; mean age: 35.5 ± 7.1 years) participated in the study. The relationship between C-IMT and haematocrit-corrected erythrocyte sedimentation rate (Hct-corrected ESR), beta 2 microglobulin (beta2M) and serum cardiac troponin I (cTnI) levels beyond C-reactive protein (CRP), lipid profile and lipoprotein(a), fibrinogen, homocysteine and left ventricular hypertrophy (LVH) were examined.Results: Mean C-IMT of the HD patients was significantly greater than that of the control subjects (0.59 ± 0.06 vs 0.53 ± 0.07 mm, P = 0.002). C-IMT of patients was positively correlated with age (r = 0.33), body mass index (r = 0.40), Hct-corrected ESR (r = 0.37), CRP (r = 0.34), beta2M (r = 0.34), cTnI (r = 0.26), triglyceride (r = 0.26) and fibrinogen (r = 0.28) levels (P < 0.05 for all). The mean C-IMT was significantly greater in patients with LVH than it was in those without LVH (P = 0.004). In multivariate regression analysis, age (P = 0.02), beta2M (P = 0.001), log-transformed CRP (P = 0.03) and LVH (P = 0.01) were independently related with C-IMT.Conclusion: Besides well-known cardiovascular (CV) risk factors, cTnI and beta2M were related with C-IMT in that they may have important roles in early-onset atherosclerosis in this high-risk population. 2005 Blackwell Publishing Journal Backfiles 1879-2005 \|2005\|\|\|\|\|\|\|\|\|\| beta 2 microglobulin SEZER, SIREN verfasserin aut DEMIRCAN, SENOL verfasserin aut SEYDAOGLU, GULSAH oth OZDEMIR, F NURHAN oth HABERAL, MEHMET oth In Nephrology Oxford [u.a.] : Wiley-Blackwell, 1995 10(2005), 5, Seite 0 Online-Ressource (DE-627)NLEJ243925859 (DE-600)2008235-6 1440-1797 nnns volume:10 year:2005 number:5 pages:0 http://dx.doi.org/10.1111/j.1440-1797.2005.00475.x text/html Verlag Deutschlandweit zugänglich Volltext GBV_USEFLAG_U ZDB-1-DJB GBV_NL_ARTICLE AR 10 2005 5 0
allfieldsGer	10.1111/j.1440-1797.2005.00475.x doi (DE-627)NLEJ243520549 DE-627 ger DE-627 rakwb ZUMRUTDAL, AYSEGUL verfasserin aut Cardiac troponin I and beta 2 microglobulin as risk factors for early-onset atherosclerosis in patients on haemodialysis Melbourne, Australia Blackwell Science Pty 2005 Online-Ressource nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Aim: To investigate the associations of different risk factors with carotid artery intima-media thickness (C-IMT) in non-diabetic haemodialysis (HD) patients who had no clinical evidence of atherosclerosis.Methods: Seventy-two HD patients (43 men, 29 women; mean age: 34.5 ± 10.6 years; mean time on HD: 47.9 ± 40.0 months) and 40 age- and sex-matched healthy controls (26 men, 14 women; mean age: 35.5 ± 7.1 years) participated in the study. The relationship between C-IMT and haematocrit-corrected erythrocyte sedimentation rate (Hct-corrected ESR), beta 2 microglobulin (beta2M) and serum cardiac troponin I (cTnI) levels beyond C-reactive protein (CRP), lipid profile and lipoprotein(a), fibrinogen, homocysteine and left ventricular hypertrophy (LVH) were examined.Results: Mean C-IMT of the HD patients was significantly greater than that of the control subjects (0.59 ± 0.06 vs 0.53 ± 0.07 mm, P = 0.002). C-IMT of patients was positively correlated with age (r = 0.33), body mass index (r = 0.40), Hct-corrected ESR (r = 0.37), CRP (r = 0.34), beta2M (r = 0.34), cTnI (r = 0.26), triglyceride (r = 0.26) and fibrinogen (r = 0.28) levels (P < 0.05 for all). The mean C-IMT was significantly greater in patients with LVH than it was in those without LVH (P = 0.004). In multivariate regression analysis, age (P = 0.02), beta2M (P = 0.001), log-transformed CRP (P = 0.03) and LVH (P = 0.01) were independently related with C-IMT.Conclusion: Besides well-known cardiovascular (CV) risk factors, cTnI and beta2M were related with C-IMT in that they may have important roles in early-onset atherosclerosis in this high-risk population. 2005 Blackwell Publishing Journal Backfiles 1879-2005 \|2005\|\|\|\|\|\|\|\|\|\| beta 2 microglobulin SEZER, SIREN verfasserin aut DEMIRCAN, SENOL verfasserin aut SEYDAOGLU, GULSAH oth OZDEMIR, F NURHAN oth HABERAL, MEHMET oth In Nephrology Oxford [u.a.] : Wiley-Blackwell, 1995 10(2005), 5, Seite 0 Online-Ressource (DE-627)NLEJ243925859 (DE-600)2008235-6 1440-1797 nnns volume:10 year:2005 number:5 pages:0 http://dx.doi.org/10.1111/j.1440-1797.2005.00475.x text/html Verlag Deutschlandweit zugänglich Volltext GBV_USEFLAG_U ZDB-1-DJB GBV_NL_ARTICLE AR 10 2005 5 0
allfieldsSound	10.1111/j.1440-1797.2005.00475.x doi (DE-627)NLEJ243520549 DE-627 ger DE-627 rakwb ZUMRUTDAL, AYSEGUL verfasserin aut Cardiac troponin I and beta 2 microglobulin as risk factors for early-onset atherosclerosis in patients on haemodialysis Melbourne, Australia Blackwell Science Pty 2005 Online-Ressource nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Aim: To investigate the associations of different risk factors with carotid artery intima-media thickness (C-IMT) in non-diabetic haemodialysis (HD) patients who had no clinical evidence of atherosclerosis.Methods: Seventy-two HD patients (43 men, 29 women; mean age: 34.5 ± 10.6 years; mean time on HD: 47.9 ± 40.0 months) and 40 age- and sex-matched healthy controls (26 men, 14 women; mean age: 35.5 ± 7.1 years) participated in the study. The relationship between C-IMT and haematocrit-corrected erythrocyte sedimentation rate (Hct-corrected ESR), beta 2 microglobulin (beta2M) and serum cardiac troponin I (cTnI) levels beyond C-reactive protein (CRP), lipid profile and lipoprotein(a), fibrinogen, homocysteine and left ventricular hypertrophy (LVH) were examined.Results: Mean C-IMT of the HD patients was significantly greater than that of the control subjects (0.59 ± 0.06 vs 0.53 ± 0.07 mm, P = 0.002). C-IMT of patients was positively correlated with age (r = 0.33), body mass index (r = 0.40), Hct-corrected ESR (r = 0.37), CRP (r = 0.34), beta2M (r = 0.34), cTnI (r = 0.26), triglyceride (r = 0.26) and fibrinogen (r = 0.28) levels (P < 0.05 for all). The mean C-IMT was significantly greater in patients with LVH than it was in those without LVH (P = 0.004). In multivariate regression analysis, age (P = 0.02), beta2M (P = 0.001), log-transformed CRP (P = 0.03) and LVH (P = 0.01) were independently related with C-IMT.Conclusion: Besides well-known cardiovascular (CV) risk factors, cTnI and beta2M were related with C-IMT in that they may have important roles in early-onset atherosclerosis in this high-risk population. 2005 Blackwell Publishing Journal Backfiles 1879-2005 \|2005\|\|\|\|\|\|\|\|\|\| beta 2 microglobulin SEZER, SIREN verfasserin aut DEMIRCAN, SENOL verfasserin aut SEYDAOGLU, GULSAH oth OZDEMIR, F NURHAN oth HABERAL, MEHMET oth In Nephrology Oxford [u.a.] : Wiley-Blackwell, 1995 10(2005), 5, Seite 0 Online-Ressource (DE-627)NLEJ243925859 (DE-600)2008235-6 1440-1797 nnns volume:10 year:2005 number:5 pages:0 http://dx.doi.org/10.1111/j.1440-1797.2005.00475.x text/html Verlag Deutschlandweit zugänglich Volltext GBV_USEFLAG_U ZDB-1-DJB GBV_NL_ARTICLE AR 10 2005 5 0
source	In Nephrology 10(2005), 5, Seite 0 volume:10 year:2005 number:5 pages:0
sourceStr	In Nephrology 10(2005), 5, Seite 0 volume:10 year:2005 number:5 pages:0
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authorswithroles_txt_mv	ZUMRUTDAL, AYSEGUL @@aut@@ SEZER, SIREN @@aut@@ DEMIRCAN, SENOL @@aut@@ SEYDAOGLU, GULSAH @@oth@@ OZDEMIR, F NURHAN @@oth@@ HABERAL, MEHMET @@oth@@
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The relationship between C-IMT and haematocrit-corrected erythrocyte sedimentation rate (Hct-corrected ESR), beta 2 microglobulin (beta2M) and serum cardiac troponin I (cTnI) levels beyond C-reactive protein (CRP), lipid profile and lipoprotein(a), fibrinogen, homocysteine and left ventricular hypertrophy (LVH) were examined.Results: Mean C-IMT of the HD patients was significantly greater than that of the control subjects (0.59 ± 0.06 vs 0.53 ± 0.07 mm, P = 0.002). C-IMT of patients was positively correlated with age (r = 0.33), body mass index (r = 0.40), Hct-corrected ESR (r = 0.37), CRP (r = 0.34), beta2M (r = 0.34), cTnI (r = 0.26), triglyceride (r = 0.26) and fibrinogen (r = 0.28) levels (P < 0.05 for all). The mean C-IMT was significantly greater in patients with LVH than it was in those without LVH (P = 0.004). In multivariate regression analysis, age (P = 0.02), beta2M (P = 0.001), log-transformed CRP (P = 0.03) and LVH (P = 0.01) were independently related with C-IMT.Conclusion: Besides well-known cardiovascular (CV) risk factors, cTnI and beta2M were related with C-IMT in that they may have important roles in early-onset atherosclerosis in this high-risk population.</subfield></datafield><datafield tag="533" ind1=" " ind2=" "><subfield code="d">2005</subfield><subfield code="f">Blackwell Publishing Journal Backfiles 1879-2005</subfield><subfield code="7">\|2005\|\|\|\|\|\|\|\|\|\|</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">beta 2 microglobulin</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">SEZER, SIREN</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">DEMIRCAN, SENOL</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">SEYDAOGLU, GULSAH</subfield><subfield code="4">oth</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">OZDEMIR, F NURHAN</subfield><subfield code="4">oth</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">HABERAL, MEHMET</subfield><subfield code="4">oth</subfield></datafield><datafield tag="773" ind1="0" ind2="8"><subfield code="i">In</subfield><subfield code="t">Nephrology</subfield><subfield code="d">Oxford [u.a.] : Wiley-Blackwell, 1995</subfield><subfield code="g">10(2005), 5, Seite 0</subfield><subfield code="h">Online-Ressource</subfield><subfield code="w">(DE-627)NLEJ243925859</subfield><subfield code="w">(DE-600)2008235-6</subfield><subfield code="x">1440-1797</subfield><subfield code="7">nnns</subfield></datafield><datafield tag="773" ind1="1" ind2="8"><subfield code="g">volume:10</subfield><subfield code="g">year:2005</subfield><subfield code="g">number:5</subfield><subfield code="g">pages:0</subfield></datafield><datafield tag="856" ind1="4" ind2="0"><subfield code="u">http://dx.doi.org/10.1111/j.1440-1797.2005.00475.x</subfield><subfield code="q">text/html</subfield><subfield code="x">Verlag</subfield><subfield code="z">Deutschlandweit zugänglich</subfield><subfield code="3">Volltext</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_USEFLAG_U</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">ZDB-1-DJB</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_NL_ARTICLE</subfield></datafield><datafield tag="951" ind1=" " ind2=" "><subfield code="a">AR</subfield></datafield><datafield tag="952" ind1=" " ind2=" "><subfield code="d">10</subfield><subfield code="j">2005</subfield><subfield code="e">5</subfield><subfield code="h">0</subfield></datafield></record></collection>
series2	Blackwell Publishing Journal Backfiles 1879-2005
author	ZUMRUTDAL, AYSEGUL
spellingShingle	ZUMRUTDAL, AYSEGUL misc beta 2 microglobulin Cardiac troponin I and beta 2 microglobulin as risk factors for early-onset atherosclerosis in patients on haemodialysis
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issn	1440-1797
topic_title	Cardiac troponin I and beta 2 microglobulin as risk factors for early-onset atherosclerosis in patients on haemodialysis beta 2 microglobulin
publisher	Blackwell Science Pty
publisherStr	Blackwell Science Pty
topic	misc beta 2 microglobulin
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title	Cardiac troponin I and beta 2 microglobulin as risk factors for early-onset atherosclerosis in patients on haemodialysis
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title_full	Cardiac troponin I and beta 2 microglobulin as risk factors for early-onset atherosclerosis in patients on haemodialysis
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author_browse	ZUMRUTDAL, AYSEGUL SEZER, SIREN DEMIRCAN, SENOL
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author-letter	ZUMRUTDAL, AYSEGUL
doi_str_mv	10.1111/j.1440-1797.2005.00475.x
author2-role	verfasserin
title_sort	cardiac troponin i and beta 2 microglobulin as risk factors for early-onset atherosclerosis in patients on haemodialysis
title_auth	Cardiac troponin I and beta 2 microglobulin as risk factors for early-onset atherosclerosis in patients on haemodialysis
abstract	Aim: To investigate the associations of different risk factors with carotid artery intima-media thickness (C-IMT) in non-diabetic haemodialysis (HD) patients who had no clinical evidence of atherosclerosis.Methods: Seventy-two HD patients (43 men, 29 women; mean age: 34.5 ± 10.6 years; mean time on HD: 47.9 ± 40.0 months) and 40 age- and sex-matched healthy controls (26 men, 14 women; mean age: 35.5 ± 7.1 years) participated in the study. The relationship between C-IMT and haematocrit-corrected erythrocyte sedimentation rate (Hct-corrected ESR), beta 2 microglobulin (beta2M) and serum cardiac troponin I (cTnI) levels beyond C-reactive protein (CRP), lipid profile and lipoprotein(a), fibrinogen, homocysteine and left ventricular hypertrophy (LVH) were examined.Results: Mean C-IMT of the HD patients was significantly greater than that of the control subjects (0.59 ± 0.06 vs 0.53 ± 0.07 mm, P = 0.002). C-IMT of patients was positively correlated with age (r = 0.33), body mass index (r = 0.40), Hct-corrected ESR (r = 0.37), CRP (r = 0.34), beta2M (r = 0.34), cTnI (r = 0.26), triglyceride (r = 0.26) and fibrinogen (r = 0.28) levels (P < 0.05 for all). The mean C-IMT was significantly greater in patients with LVH than it was in those without LVH (P = 0.004). In multivariate regression analysis, age (P = 0.02), beta2M (P = 0.001), log-transformed CRP (P = 0.03) and LVH (P = 0.01) were independently related with C-IMT.Conclusion: Besides well-known cardiovascular (CV) risk factors, cTnI and beta2M were related with C-IMT in that they may have important roles in early-onset atherosclerosis in this high-risk population.
abstractGer	Aim: To investigate the associations of different risk factors with carotid artery intima-media thickness (C-IMT) in non-diabetic haemodialysis (HD) patients who had no clinical evidence of atherosclerosis.Methods: Seventy-two HD patients (43 men, 29 women; mean age: 34.5 ± 10.6 years; mean time on HD: 47.9 ± 40.0 months) and 40 age- and sex-matched healthy controls (26 men, 14 women; mean age: 35.5 ± 7.1 years) participated in the study. The relationship between C-IMT and haematocrit-corrected erythrocyte sedimentation rate (Hct-corrected ESR), beta 2 microglobulin (beta2M) and serum cardiac troponin I (cTnI) levels beyond C-reactive protein (CRP), lipid profile and lipoprotein(a), fibrinogen, homocysteine and left ventricular hypertrophy (LVH) were examined.Results: Mean C-IMT of the HD patients was significantly greater than that of the control subjects (0.59 ± 0.06 vs 0.53 ± 0.07 mm, P = 0.002). C-IMT of patients was positively correlated with age (r = 0.33), body mass index (r = 0.40), Hct-corrected ESR (r = 0.37), CRP (r = 0.34), beta2M (r = 0.34), cTnI (r = 0.26), triglyceride (r = 0.26) and fibrinogen (r = 0.28) levels (P < 0.05 for all). The mean C-IMT was significantly greater in patients with LVH than it was in those without LVH (P = 0.004). In multivariate regression analysis, age (P = 0.02), beta2M (P = 0.001), log-transformed CRP (P = 0.03) and LVH (P = 0.01) were independently related with C-IMT.Conclusion: Besides well-known cardiovascular (CV) risk factors, cTnI and beta2M were related with C-IMT in that they may have important roles in early-onset atherosclerosis in this high-risk population.
abstract_unstemmed	Aim: To investigate the associations of different risk factors with carotid artery intima-media thickness (C-IMT) in non-diabetic haemodialysis (HD) patients who had no clinical evidence of atherosclerosis.Methods: Seventy-two HD patients (43 men, 29 women; mean age: 34.5 ± 10.6 years; mean time on HD: 47.9 ± 40.0 months) and 40 age- and sex-matched healthy controls (26 men, 14 women; mean age: 35.5 ± 7.1 years) participated in the study. The relationship between C-IMT and haematocrit-corrected erythrocyte sedimentation rate (Hct-corrected ESR), beta 2 microglobulin (beta2M) and serum cardiac troponin I (cTnI) levels beyond C-reactive protein (CRP), lipid profile and lipoprotein(a), fibrinogen, homocysteine and left ventricular hypertrophy (LVH) were examined.Results: Mean C-IMT of the HD patients was significantly greater than that of the control subjects (0.59 ± 0.06 vs 0.53 ± 0.07 mm, P = 0.002). C-IMT of patients was positively correlated with age (r = 0.33), body mass index (r = 0.40), Hct-corrected ESR (r = 0.37), CRP (r = 0.34), beta2M (r = 0.34), cTnI (r = 0.26), triglyceride (r = 0.26) and fibrinogen (r = 0.28) levels (P < 0.05 for all). The mean C-IMT was significantly greater in patients with LVH than it was in those without LVH (P = 0.004). In multivariate regression analysis, age (P = 0.02), beta2M (P = 0.001), log-transformed CRP (P = 0.03) and LVH (P = 0.01) were independently related with C-IMT.Conclusion: Besides well-known cardiovascular (CV) risk factors, cTnI and beta2M were related with C-IMT in that they may have important roles in early-onset atherosclerosis in this high-risk population.
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title_short	Cardiac troponin I and beta 2 microglobulin as risk factors for early-onset atherosclerosis in patients on haemodialysis
url	http://dx.doi.org/10.1111/j.1440-1797.2005.00475.x
remote_bool	true
author2	SEZER, SIREN DEMIRCAN, SENOL SEYDAOGLU, GULSAH OZDEMIR, F NURHAN HABERAL, MEHMET
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doi_str	10.1111/j.1440-1797.2005.00475.x
up_date	2024-07-06T05:42:53.793Z
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