Evidence of oxidative stress in chronic venous ulcers
Reactive oxygen species have been implicated in the impaired healing of chronic leg ulcers but little direct evidence is available. We have observed a significant (p < 0.01) elevation of the allantoin : uric acid percentage ratio, a marker of oxidative stress, in wound fluid from chronic leg ulce...
Ausführliche Beschreibung
Gespeichert in:
| Autor*in: |
James, Tim J. - MSc [verfasserIn] Hughes, Margaret A. - PhD [verfasserIn] Cherry, George W. - DPhil [verfasserIn] Taylor, Richard P. - PhD |
|---|
| Format: |
E-Artikel |
|---|
| Erschienen: |
Malden, USA: Blackwell Science Inc ; 2003 |
|---|
| Umfang: |
Online-Ressource |
|---|
| Reproduktion: |
2003 ; Blackwell Publishing Journal Backfiles 1879-2005 |
|---|---|
| Übergeordnetes Werk: |
In: Wound repair and regeneration - Oxford [u.a.] : Wiley-Blackwell, 1993, 11(2003), 3, Seite 0 |
| Übergeordnetes Werk: |
volume:11 ; year:2003 ; number:3 ; pages:0 |
| Links: |
|---|
| DOI / URN: |
10.1046/j.1524-475X.2003.11304.x |
|---|
| Katalog-ID: |
NLEJ243617011 |
|---|
| LEADER | 01000caa a22002652 4500 | ||
|---|---|---|---|
| 001 | NLEJ243617011 | ||
| 003 | DE-627 | ||
| 005 | 20210707183502.0 | ||
| 007 | cr uuu---uuuuu | ||
| 008 | 120427s2003 xx |||||o 00| ||und c | ||
| 024 | 7 | |a 10.1046/j.1524-475X.2003.11304.x |2 doi | |
| 035 | |a (DE-627)NLEJ243617011 | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rakwb | ||
| 100 | 1 | |a James, Tim J. |c MSc |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a Evidence of oxidative stress in chronic venous ulcers |
| 264 | 1 | |a Malden, USA |b Blackwell Science Inc |c 2003 | |
| 300 | |a Online-Ressource | ||
| 336 | |a nicht spezifiziert |b zzz |2 rdacontent | ||
| 337 | |a nicht spezifiziert |b z |2 rdamedia | ||
| 338 | |a nicht spezifiziert |b zu |2 rdacarrier | ||
| 520 | |a Reactive oxygen species have been implicated in the impaired healing of chronic leg ulcers but little direct evidence is available. We have observed a significant (p < 0.01) elevation of the allantoin : uric acid percentage ratio, a marker of oxidative stress, in wound fluid from chronic leg ulcers (median 17, range 8–860) compared to both paired plasma (median 2, range 1–8) and acute surgical wound fluid (median 4, range 3–7). However, the allantoin : uric acid percentage ratio did not differ significantly between chronic wounds that healed and those that failed to heal. Neutrophil elastase was elevated 30- to 1300-fold in chronic wound fluid compared to plasma and there was a correlation (r 2 = 0.742) between wound fluid elastase and the allantoin : uric acid percentage ratio. Total antioxidant capacity of wound fluid, as measured with a chemiluminescence assay, did not show a correlation (r 2 = 0.03) with the observed oxidative stress. These observations suggest that conditions of localized oxidative stress, possibly related to neutrophil-associated production of reactive oxygen species, are present in chronic leg ulcers. It is possible that future therapeutic strategies aimed at reducing oxidative stress, in addition to good standard care, could improve healing rates of chronic wounds. (WOUND REP REG 2003;11:172–176) | ||
| 533 | |d 2003 |f Blackwell Publishing Journal Backfiles 1879-2005 |7 |2003|||||||||| | ||
| 700 | 1 | |a Hughes, Margaret A. |c PhD |e verfasserin |4 aut | |
| 700 | 1 | |a Cherry, George W. |c DPhil |e verfasserin |4 aut | |
| 700 | 1 | |a Taylor, Richard P. |c PhD |4 oth | |
| 773 | 0 | 8 | |i In |t Wound repair and regeneration |d Oxford [u.a.] : Wiley-Blackwell, 1993 |g 11(2003), 3, Seite 0 |h Online-Ressource |w (DE-627)NLEJ243925980 |w (DE-600)2011990-2 |x 1524-475X |7 nnns |
| 773 | 1 | 8 | |g volume:11 |g year:2003 |g number:3 |g pages:0 |
| 856 | 4 | 0 | |u http://dx.doi.org/10.1046/j.1524-475X.2003.11304.x |q text/html |x Verlag |z Deutschlandweit zugänglich |3 Volltext |
| 912 | |a GBV_USEFLAG_U | ||
| 912 | |a ZDB-1-DJB | ||
| 912 | |a GBV_NL_ARTICLE | ||
| 951 | |a AR | ||
| 952 | |d 11 |j 2003 |e 3 |h 0 | ||
| author_variant |
t j j tj tjj m a h ma mah g w c gw gwc |
|---|---|
| matchkey_str |
article:1524475X:2003----::vdnefxdtvsrsicrn |
| hierarchy_sort_str |
2003 |
| publishDate |
2003 |
| allfields |
10.1046/j.1524-475X.2003.11304.x doi (DE-627)NLEJ243617011 DE-627 ger DE-627 rakwb James, Tim J. MSc verfasserin aut Evidence of oxidative stress in chronic venous ulcers Malden, USA Blackwell Science Inc 2003 Online-Ressource nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Reactive oxygen species have been implicated in the impaired healing of chronic leg ulcers but little direct evidence is available. We have observed a significant (p < 0.01) elevation of the allantoin : uric acid percentage ratio, a marker of oxidative stress, in wound fluid from chronic leg ulcers (median 17, range 8–860) compared to both paired plasma (median 2, range 1–8) and acute surgical wound fluid (median 4, range 3–7). However, the allantoin : uric acid percentage ratio did not differ significantly between chronic wounds that healed and those that failed to heal. Neutrophil elastase was elevated 30- to 1300-fold in chronic wound fluid compared to plasma and there was a correlation (r 2 = 0.742) between wound fluid elastase and the allantoin : uric acid percentage ratio. Total antioxidant capacity of wound fluid, as measured with a chemiluminescence assay, did not show a correlation (r 2 = 0.03) with the observed oxidative stress. These observations suggest that conditions of localized oxidative stress, possibly related to neutrophil-associated production of reactive oxygen species, are present in chronic leg ulcers. It is possible that future therapeutic strategies aimed at reducing oxidative stress, in addition to good standard care, could improve healing rates of chronic wounds. (WOUND REP REG 2003;11:172–176) 2003 Blackwell Publishing Journal Backfiles 1879-2005 |2003|||||||||| Hughes, Margaret A. PhD verfasserin aut Cherry, George W. DPhil verfasserin aut Taylor, Richard P. PhD oth In Wound repair and regeneration Oxford [u.a.] : Wiley-Blackwell, 1993 11(2003), 3, Seite 0 Online-Ressource (DE-627)NLEJ243925980 (DE-600)2011990-2 1524-475X nnns volume:11 year:2003 number:3 pages:0 http://dx.doi.org/10.1046/j.1524-475X.2003.11304.x text/html Verlag Deutschlandweit zugänglich Volltext GBV_USEFLAG_U ZDB-1-DJB GBV_NL_ARTICLE AR 11 2003 3 0 |
| spelling |
10.1046/j.1524-475X.2003.11304.x doi (DE-627)NLEJ243617011 DE-627 ger DE-627 rakwb James, Tim J. MSc verfasserin aut Evidence of oxidative stress in chronic venous ulcers Malden, USA Blackwell Science Inc 2003 Online-Ressource nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Reactive oxygen species have been implicated in the impaired healing of chronic leg ulcers but little direct evidence is available. We have observed a significant (p < 0.01) elevation of the allantoin : uric acid percentage ratio, a marker of oxidative stress, in wound fluid from chronic leg ulcers (median 17, range 8–860) compared to both paired plasma (median 2, range 1–8) and acute surgical wound fluid (median 4, range 3–7). However, the allantoin : uric acid percentage ratio did not differ significantly between chronic wounds that healed and those that failed to heal. Neutrophil elastase was elevated 30- to 1300-fold in chronic wound fluid compared to plasma and there was a correlation (r 2 = 0.742) between wound fluid elastase and the allantoin : uric acid percentage ratio. Total antioxidant capacity of wound fluid, as measured with a chemiluminescence assay, did not show a correlation (r 2 = 0.03) with the observed oxidative stress. These observations suggest that conditions of localized oxidative stress, possibly related to neutrophil-associated production of reactive oxygen species, are present in chronic leg ulcers. It is possible that future therapeutic strategies aimed at reducing oxidative stress, in addition to good standard care, could improve healing rates of chronic wounds. (WOUND REP REG 2003;11:172–176) 2003 Blackwell Publishing Journal Backfiles 1879-2005 |2003|||||||||| Hughes, Margaret A. PhD verfasserin aut Cherry, George W. DPhil verfasserin aut Taylor, Richard P. PhD oth In Wound repair and regeneration Oxford [u.a.] : Wiley-Blackwell, 1993 11(2003), 3, Seite 0 Online-Ressource (DE-627)NLEJ243925980 (DE-600)2011990-2 1524-475X nnns volume:11 year:2003 number:3 pages:0 http://dx.doi.org/10.1046/j.1524-475X.2003.11304.x text/html Verlag Deutschlandweit zugänglich Volltext GBV_USEFLAG_U ZDB-1-DJB GBV_NL_ARTICLE AR 11 2003 3 0 |
| allfields_unstemmed |
10.1046/j.1524-475X.2003.11304.x doi (DE-627)NLEJ243617011 DE-627 ger DE-627 rakwb James, Tim J. MSc verfasserin aut Evidence of oxidative stress in chronic venous ulcers Malden, USA Blackwell Science Inc 2003 Online-Ressource nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Reactive oxygen species have been implicated in the impaired healing of chronic leg ulcers but little direct evidence is available. We have observed a significant (p < 0.01) elevation of the allantoin : uric acid percentage ratio, a marker of oxidative stress, in wound fluid from chronic leg ulcers (median 17, range 8–860) compared to both paired plasma (median 2, range 1–8) and acute surgical wound fluid (median 4, range 3–7). However, the allantoin : uric acid percentage ratio did not differ significantly between chronic wounds that healed and those that failed to heal. Neutrophil elastase was elevated 30- to 1300-fold in chronic wound fluid compared to plasma and there was a correlation (r 2 = 0.742) between wound fluid elastase and the allantoin : uric acid percentage ratio. Total antioxidant capacity of wound fluid, as measured with a chemiluminescence assay, did not show a correlation (r 2 = 0.03) with the observed oxidative stress. These observations suggest that conditions of localized oxidative stress, possibly related to neutrophil-associated production of reactive oxygen species, are present in chronic leg ulcers. It is possible that future therapeutic strategies aimed at reducing oxidative stress, in addition to good standard care, could improve healing rates of chronic wounds. (WOUND REP REG 2003;11:172–176) 2003 Blackwell Publishing Journal Backfiles 1879-2005 |2003|||||||||| Hughes, Margaret A. PhD verfasserin aut Cherry, George W. DPhil verfasserin aut Taylor, Richard P. PhD oth In Wound repair and regeneration Oxford [u.a.] : Wiley-Blackwell, 1993 11(2003), 3, Seite 0 Online-Ressource (DE-627)NLEJ243925980 (DE-600)2011990-2 1524-475X nnns volume:11 year:2003 number:3 pages:0 http://dx.doi.org/10.1046/j.1524-475X.2003.11304.x text/html Verlag Deutschlandweit zugänglich Volltext GBV_USEFLAG_U ZDB-1-DJB GBV_NL_ARTICLE AR 11 2003 3 0 |
| allfieldsGer |
10.1046/j.1524-475X.2003.11304.x doi (DE-627)NLEJ243617011 DE-627 ger DE-627 rakwb James, Tim J. MSc verfasserin aut Evidence of oxidative stress in chronic venous ulcers Malden, USA Blackwell Science Inc 2003 Online-Ressource nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Reactive oxygen species have been implicated in the impaired healing of chronic leg ulcers but little direct evidence is available. We have observed a significant (p < 0.01) elevation of the allantoin : uric acid percentage ratio, a marker of oxidative stress, in wound fluid from chronic leg ulcers (median 17, range 8–860) compared to both paired plasma (median 2, range 1–8) and acute surgical wound fluid (median 4, range 3–7). However, the allantoin : uric acid percentage ratio did not differ significantly between chronic wounds that healed and those that failed to heal. Neutrophil elastase was elevated 30- to 1300-fold in chronic wound fluid compared to plasma and there was a correlation (r 2 = 0.742) between wound fluid elastase and the allantoin : uric acid percentage ratio. Total antioxidant capacity of wound fluid, as measured with a chemiluminescence assay, did not show a correlation (r 2 = 0.03) with the observed oxidative stress. These observations suggest that conditions of localized oxidative stress, possibly related to neutrophil-associated production of reactive oxygen species, are present in chronic leg ulcers. It is possible that future therapeutic strategies aimed at reducing oxidative stress, in addition to good standard care, could improve healing rates of chronic wounds. (WOUND REP REG 2003;11:172–176) 2003 Blackwell Publishing Journal Backfiles 1879-2005 |2003|||||||||| Hughes, Margaret A. PhD verfasserin aut Cherry, George W. DPhil verfasserin aut Taylor, Richard P. PhD oth In Wound repair and regeneration Oxford [u.a.] : Wiley-Blackwell, 1993 11(2003), 3, Seite 0 Online-Ressource (DE-627)NLEJ243925980 (DE-600)2011990-2 1524-475X nnns volume:11 year:2003 number:3 pages:0 http://dx.doi.org/10.1046/j.1524-475X.2003.11304.x text/html Verlag Deutschlandweit zugänglich Volltext GBV_USEFLAG_U ZDB-1-DJB GBV_NL_ARTICLE AR 11 2003 3 0 |
| allfieldsSound |
10.1046/j.1524-475X.2003.11304.x doi (DE-627)NLEJ243617011 DE-627 ger DE-627 rakwb James, Tim J. MSc verfasserin aut Evidence of oxidative stress in chronic venous ulcers Malden, USA Blackwell Science Inc 2003 Online-Ressource nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Reactive oxygen species have been implicated in the impaired healing of chronic leg ulcers but little direct evidence is available. We have observed a significant (p < 0.01) elevation of the allantoin : uric acid percentage ratio, a marker of oxidative stress, in wound fluid from chronic leg ulcers (median 17, range 8–860) compared to both paired plasma (median 2, range 1–8) and acute surgical wound fluid (median 4, range 3–7). However, the allantoin : uric acid percentage ratio did not differ significantly between chronic wounds that healed and those that failed to heal. Neutrophil elastase was elevated 30- to 1300-fold in chronic wound fluid compared to plasma and there was a correlation (r 2 = 0.742) between wound fluid elastase and the allantoin : uric acid percentage ratio. Total antioxidant capacity of wound fluid, as measured with a chemiluminescence assay, did not show a correlation (r 2 = 0.03) with the observed oxidative stress. These observations suggest that conditions of localized oxidative stress, possibly related to neutrophil-associated production of reactive oxygen species, are present in chronic leg ulcers. It is possible that future therapeutic strategies aimed at reducing oxidative stress, in addition to good standard care, could improve healing rates of chronic wounds. (WOUND REP REG 2003;11:172–176) 2003 Blackwell Publishing Journal Backfiles 1879-2005 |2003|||||||||| Hughes, Margaret A. PhD verfasserin aut Cherry, George W. DPhil verfasserin aut Taylor, Richard P. PhD oth In Wound repair and regeneration Oxford [u.a.] : Wiley-Blackwell, 1993 11(2003), 3, Seite 0 Online-Ressource (DE-627)NLEJ243925980 (DE-600)2011990-2 1524-475X nnns volume:11 year:2003 number:3 pages:0 http://dx.doi.org/10.1046/j.1524-475X.2003.11304.x text/html Verlag Deutschlandweit zugänglich Volltext GBV_USEFLAG_U ZDB-1-DJB GBV_NL_ARTICLE AR 11 2003 3 0 |
| source |
In Wound repair and regeneration 11(2003), 3, Seite 0 volume:11 year:2003 number:3 pages:0 |
| sourceStr |
In Wound repair and regeneration 11(2003), 3, Seite 0 volume:11 year:2003 number:3 pages:0 |
| format_phy_str_mv |
Article |
| institution |
findex.gbv.de |
| isfreeaccess_bool |
false |
| container_title |
Wound repair and regeneration |
| authorswithroles_txt_mv |
James, Tim J. @@aut@@ Hughes, Margaret A. @@aut@@ Cherry, George W. @@aut@@ Taylor, Richard P. @@oth@@ |
| publishDateDaySort_date |
2003-01-01T00:00:00Z |
| hierarchy_top_id |
NLEJ243925980 |
| id |
NLEJ243617011 |
| fullrecord |
<?xml version="1.0" encoding="UTF-8"?><collection xmlns="http://www.loc.gov/MARC21/slim"><record><leader>01000caa a22002652 4500</leader><controlfield tag="001">NLEJ243617011</controlfield><controlfield tag="003">DE-627</controlfield><controlfield tag="005">20210707183502.0</controlfield><controlfield tag="007">cr uuu---uuuuu</controlfield><controlfield tag="008">120427s2003 xx |||||o 00| ||und c</controlfield><datafield tag="024" ind1="7" ind2=" "><subfield code="a">10.1046/j.1524-475X.2003.11304.x</subfield><subfield code="2">doi</subfield></datafield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(DE-627)NLEJ243617011</subfield></datafield><datafield tag="040" ind1=" " ind2=" "><subfield code="a">DE-627</subfield><subfield code="b">ger</subfield><subfield code="c">DE-627</subfield><subfield code="e">rakwb</subfield></datafield><datafield tag="100" ind1="1" ind2=" "><subfield code="a">James, Tim J.</subfield><subfield code="c">MSc</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="245" ind1="1" ind2="0"><subfield code="a">Evidence of oxidative stress in chronic venous ulcers</subfield></datafield><datafield tag="264" ind1=" " ind2="1"><subfield code="a">Malden, USA</subfield><subfield code="b">Blackwell Science Inc</subfield><subfield code="c">2003</subfield></datafield><datafield tag="300" ind1=" " ind2=" "><subfield code="a">Online-Ressource</subfield></datafield><datafield tag="336" ind1=" " ind2=" "><subfield code="a">nicht spezifiziert</subfield><subfield code="b">zzz</subfield><subfield code="2">rdacontent</subfield></datafield><datafield tag="337" ind1=" " ind2=" "><subfield code="a">nicht spezifiziert</subfield><subfield code="b">z</subfield><subfield code="2">rdamedia</subfield></datafield><datafield tag="338" ind1=" " ind2=" "><subfield code="a">nicht spezifiziert</subfield><subfield code="b">zu</subfield><subfield code="2">rdacarrier</subfield></datafield><datafield tag="520" ind1=" " ind2=" "><subfield code="a">Reactive oxygen species have been implicated in the impaired healing of chronic leg ulcers but little direct evidence is available. We have observed a significant (p < 0.01) elevation of the allantoin : uric acid percentage ratio, a marker of oxidative stress, in wound fluid from chronic leg ulcers (median 17, range 8–860) compared to both paired plasma (median 2, range 1–8) and acute surgical wound fluid (median 4, range 3–7). However, the allantoin : uric acid percentage ratio did not differ significantly between chronic wounds that healed and those that failed to heal. Neutrophil elastase was elevated 30- to 1300-fold in chronic wound fluid compared to plasma and there was a correlation (r 2 = 0.742) between wound fluid elastase and the allantoin : uric acid percentage ratio. Total antioxidant capacity of wound fluid, as measured with a chemiluminescence assay, did not show a correlation (r 2 = 0.03) with the observed oxidative stress. These observations suggest that conditions of localized oxidative stress, possibly related to neutrophil-associated production of reactive oxygen species, are present in chronic leg ulcers. It is possible that future therapeutic strategies aimed at reducing oxidative stress, in addition to good standard care, could improve healing rates of chronic wounds. (WOUND REP REG 2003;11:172–176)</subfield></datafield><datafield tag="533" ind1=" " ind2=" "><subfield code="d">2003</subfield><subfield code="f">Blackwell Publishing Journal Backfiles 1879-2005</subfield><subfield code="7">|2003||||||||||</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Hughes, Margaret A.</subfield><subfield code="c">PhD</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Cherry, George W.</subfield><subfield code="c">DPhil</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Taylor, Richard P.</subfield><subfield code="c">PhD</subfield><subfield code="4">oth</subfield></datafield><datafield tag="773" ind1="0" ind2="8"><subfield code="i">In</subfield><subfield code="t">Wound repair and regeneration</subfield><subfield code="d">Oxford [u.a.] : Wiley-Blackwell, 1993</subfield><subfield code="g">11(2003), 3, Seite 0</subfield><subfield code="h">Online-Ressource</subfield><subfield code="w">(DE-627)NLEJ243925980</subfield><subfield code="w">(DE-600)2011990-2</subfield><subfield code="x">1524-475X</subfield><subfield code="7">nnns</subfield></datafield><datafield tag="773" ind1="1" ind2="8"><subfield code="g">volume:11</subfield><subfield code="g">year:2003</subfield><subfield code="g">number:3</subfield><subfield code="g">pages:0</subfield></datafield><datafield tag="856" ind1="4" ind2="0"><subfield code="u">http://dx.doi.org/10.1046/j.1524-475X.2003.11304.x</subfield><subfield code="q">text/html</subfield><subfield code="x">Verlag</subfield><subfield code="z">Deutschlandweit zugänglich</subfield><subfield code="3">Volltext</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_USEFLAG_U</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">ZDB-1-DJB</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_NL_ARTICLE</subfield></datafield><datafield tag="951" ind1=" " ind2=" "><subfield code="a">AR</subfield></datafield><datafield tag="952" ind1=" " ind2=" "><subfield code="d">11</subfield><subfield code="j">2003</subfield><subfield code="e">3</subfield><subfield code="h">0</subfield></datafield></record></collection>
|
| series2 |
Blackwell Publishing Journal Backfiles 1879-2005 |
| author |
James, Tim J. MSc |
| spellingShingle |
James, Tim J. MSc Evidence of oxidative stress in chronic venous ulcers |
| authorStr |
James, Tim J. MSc |
| ppnlink_with_tag_str_mv |
@@773@@(DE-627)NLEJ243925980 |
| format |
electronic Article |
| delete_txt_mv |
keep |
| author_role |
aut aut aut |
| collection |
NL |
| publishPlace |
Malden, USA |
| remote_str |
true |
| illustrated |
Not Illustrated |
| issn |
1524-475X |
| topic_title |
Evidence of oxidative stress in chronic venous ulcers |
| publisher |
Blackwell Science Inc |
| publisherStr |
Blackwell Science Inc |
| format_facet |
Elektronische Aufsätze Aufsätze Elektronische Ressource |
| format_main_str_mv |
Text Zeitschrift/Artikel |
| carriertype_str_mv |
zu |
| author2_variant |
r p t rp rpt |
| hierarchy_parent_title |
Wound repair and regeneration |
| hierarchy_parent_id |
NLEJ243925980 |
| hierarchy_top_title |
Wound repair and regeneration |
| isfreeaccess_txt |
false |
| familylinks_str_mv |
(DE-627)NLEJ243925980 (DE-600)2011990-2 |
| title |
Evidence of oxidative stress in chronic venous ulcers |
| ctrlnum |
(DE-627)NLEJ243617011 |
| title_full |
Evidence of oxidative stress in chronic venous ulcers |
| author_sort |
James, Tim J. MSc |
| journal |
Wound repair and regeneration |
| journalStr |
Wound repair and regeneration |
| isOA_bool |
false |
| recordtype |
marc |
| publishDateSort |
2003 |
| contenttype_str_mv |
zzz |
| container_start_page |
0 |
| author_browse |
James, Tim J. Hughes, Margaret A. Cherry, George W. |
| container_volume |
11 |
| physical |
Online-Ressource |
| format_se |
Elektronische Aufsätze |
| author-letter |
James, Tim J. |
| doi_str_mv |
10.1046/j.1524-475X.2003.11304.x |
| author2-role |
verfasserin |
| title_sort |
evidence of oxidative stress in chronic venous ulcers |
| title_auth |
Evidence of oxidative stress in chronic venous ulcers |
| abstract |
Reactive oxygen species have been implicated in the impaired healing of chronic leg ulcers but little direct evidence is available. We have observed a significant (p < 0.01) elevation of the allantoin : uric acid percentage ratio, a marker of oxidative stress, in wound fluid from chronic leg ulcers (median 17, range 8–860) compared to both paired plasma (median 2, range 1–8) and acute surgical wound fluid (median 4, range 3–7). However, the allantoin : uric acid percentage ratio did not differ significantly between chronic wounds that healed and those that failed to heal. Neutrophil elastase was elevated 30- to 1300-fold in chronic wound fluid compared to plasma and there was a correlation (r 2 = 0.742) between wound fluid elastase and the allantoin : uric acid percentage ratio. Total antioxidant capacity of wound fluid, as measured with a chemiluminescence assay, did not show a correlation (r 2 = 0.03) with the observed oxidative stress. These observations suggest that conditions of localized oxidative stress, possibly related to neutrophil-associated production of reactive oxygen species, are present in chronic leg ulcers. It is possible that future therapeutic strategies aimed at reducing oxidative stress, in addition to good standard care, could improve healing rates of chronic wounds. (WOUND REP REG 2003;11:172–176) |
| abstractGer |
Reactive oxygen species have been implicated in the impaired healing of chronic leg ulcers but little direct evidence is available. We have observed a significant (p < 0.01) elevation of the allantoin : uric acid percentage ratio, a marker of oxidative stress, in wound fluid from chronic leg ulcers (median 17, range 8–860) compared to both paired plasma (median 2, range 1–8) and acute surgical wound fluid (median 4, range 3–7). However, the allantoin : uric acid percentage ratio did not differ significantly between chronic wounds that healed and those that failed to heal. Neutrophil elastase was elevated 30- to 1300-fold in chronic wound fluid compared to plasma and there was a correlation (r 2 = 0.742) between wound fluid elastase and the allantoin : uric acid percentage ratio. Total antioxidant capacity of wound fluid, as measured with a chemiluminescence assay, did not show a correlation (r 2 = 0.03) with the observed oxidative stress. These observations suggest that conditions of localized oxidative stress, possibly related to neutrophil-associated production of reactive oxygen species, are present in chronic leg ulcers. It is possible that future therapeutic strategies aimed at reducing oxidative stress, in addition to good standard care, could improve healing rates of chronic wounds. (WOUND REP REG 2003;11:172–176) |
| abstract_unstemmed |
Reactive oxygen species have been implicated in the impaired healing of chronic leg ulcers but little direct evidence is available. We have observed a significant (p < 0.01) elevation of the allantoin : uric acid percentage ratio, a marker of oxidative stress, in wound fluid from chronic leg ulcers (median 17, range 8–860) compared to both paired plasma (median 2, range 1–8) and acute surgical wound fluid (median 4, range 3–7). However, the allantoin : uric acid percentage ratio did not differ significantly between chronic wounds that healed and those that failed to heal. Neutrophil elastase was elevated 30- to 1300-fold in chronic wound fluid compared to plasma and there was a correlation (r 2 = 0.742) between wound fluid elastase and the allantoin : uric acid percentage ratio. Total antioxidant capacity of wound fluid, as measured with a chemiluminescence assay, did not show a correlation (r 2 = 0.03) with the observed oxidative stress. These observations suggest that conditions of localized oxidative stress, possibly related to neutrophil-associated production of reactive oxygen species, are present in chronic leg ulcers. It is possible that future therapeutic strategies aimed at reducing oxidative stress, in addition to good standard care, could improve healing rates of chronic wounds. (WOUND REP REG 2003;11:172–176) |
| collection_details |
GBV_USEFLAG_U ZDB-1-DJB GBV_NL_ARTICLE |
| container_issue |
3 |
| title_short |
Evidence of oxidative stress in chronic venous ulcers |
| url |
http://dx.doi.org/10.1046/j.1524-475X.2003.11304.x |
| remote_bool |
true |
| author2 |
Hughes, Margaret A. PhD Cherry, George W. DPhil Taylor, Richard P. PhD |
| author2Str |
Hughes, Margaret A. PhD Cherry, George W. DPhil Taylor, Richard P. PhD |
| ppnlink |
NLEJ243925980 |
| mediatype_str_mv |
z |
| isOA_txt |
false |
| hochschulschrift_bool |
false |
| author2_role |
oth |
| doi_str |
10.1046/j.1524-475X.2003.11304.x |
| up_date |
2024-07-06T06:01:43.287Z |
| _version_ |
1803808358570917888 |
| fullrecord_marcxml |
<?xml version="1.0" encoding="UTF-8"?><collection xmlns="http://www.loc.gov/MARC21/slim"><record><leader>01000caa a22002652 4500</leader><controlfield tag="001">NLEJ243617011</controlfield><controlfield tag="003">DE-627</controlfield><controlfield tag="005">20210707183502.0</controlfield><controlfield tag="007">cr uuu---uuuuu</controlfield><controlfield tag="008">120427s2003 xx |||||o 00| ||und c</controlfield><datafield tag="024" ind1="7" ind2=" "><subfield code="a">10.1046/j.1524-475X.2003.11304.x</subfield><subfield code="2">doi</subfield></datafield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(DE-627)NLEJ243617011</subfield></datafield><datafield tag="040" ind1=" " ind2=" "><subfield code="a">DE-627</subfield><subfield code="b">ger</subfield><subfield code="c">DE-627</subfield><subfield code="e">rakwb</subfield></datafield><datafield tag="100" ind1="1" ind2=" "><subfield code="a">James, Tim J.</subfield><subfield code="c">MSc</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="245" ind1="1" ind2="0"><subfield code="a">Evidence of oxidative stress in chronic venous ulcers</subfield></datafield><datafield tag="264" ind1=" " ind2="1"><subfield code="a">Malden, USA</subfield><subfield code="b">Blackwell Science Inc</subfield><subfield code="c">2003</subfield></datafield><datafield tag="300" ind1=" " ind2=" "><subfield code="a">Online-Ressource</subfield></datafield><datafield tag="336" ind1=" " ind2=" "><subfield code="a">nicht spezifiziert</subfield><subfield code="b">zzz</subfield><subfield code="2">rdacontent</subfield></datafield><datafield tag="337" ind1=" " ind2=" "><subfield code="a">nicht spezifiziert</subfield><subfield code="b">z</subfield><subfield code="2">rdamedia</subfield></datafield><datafield tag="338" ind1=" " ind2=" "><subfield code="a">nicht spezifiziert</subfield><subfield code="b">zu</subfield><subfield code="2">rdacarrier</subfield></datafield><datafield tag="520" ind1=" " ind2=" "><subfield code="a">Reactive oxygen species have been implicated in the impaired healing of chronic leg ulcers but little direct evidence is available. We have observed a significant (p < 0.01) elevation of the allantoin : uric acid percentage ratio, a marker of oxidative stress, in wound fluid from chronic leg ulcers (median 17, range 8–860) compared to both paired plasma (median 2, range 1–8) and acute surgical wound fluid (median 4, range 3–7). However, the allantoin : uric acid percentage ratio did not differ significantly between chronic wounds that healed and those that failed to heal. Neutrophil elastase was elevated 30- to 1300-fold in chronic wound fluid compared to plasma and there was a correlation (r 2 = 0.742) between wound fluid elastase and the allantoin : uric acid percentage ratio. Total antioxidant capacity of wound fluid, as measured with a chemiluminescence assay, did not show a correlation (r 2 = 0.03) with the observed oxidative stress. These observations suggest that conditions of localized oxidative stress, possibly related to neutrophil-associated production of reactive oxygen species, are present in chronic leg ulcers. It is possible that future therapeutic strategies aimed at reducing oxidative stress, in addition to good standard care, could improve healing rates of chronic wounds. (WOUND REP REG 2003;11:172–176)</subfield></datafield><datafield tag="533" ind1=" " ind2=" "><subfield code="d">2003</subfield><subfield code="f">Blackwell Publishing Journal Backfiles 1879-2005</subfield><subfield code="7">|2003||||||||||</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Hughes, Margaret A.</subfield><subfield code="c">PhD</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Cherry, George W.</subfield><subfield code="c">DPhil</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Taylor, Richard P.</subfield><subfield code="c">PhD</subfield><subfield code="4">oth</subfield></datafield><datafield tag="773" ind1="0" ind2="8"><subfield code="i">In</subfield><subfield code="t">Wound repair and regeneration</subfield><subfield code="d">Oxford [u.a.] : Wiley-Blackwell, 1993</subfield><subfield code="g">11(2003), 3, Seite 0</subfield><subfield code="h">Online-Ressource</subfield><subfield code="w">(DE-627)NLEJ243925980</subfield><subfield code="w">(DE-600)2011990-2</subfield><subfield code="x">1524-475X</subfield><subfield code="7">nnns</subfield></datafield><datafield tag="773" ind1="1" ind2="8"><subfield code="g">volume:11</subfield><subfield code="g">year:2003</subfield><subfield code="g">number:3</subfield><subfield code="g">pages:0</subfield></datafield><datafield tag="856" ind1="4" ind2="0"><subfield code="u">http://dx.doi.org/10.1046/j.1524-475X.2003.11304.x</subfield><subfield code="q">text/html</subfield><subfield code="x">Verlag</subfield><subfield code="z">Deutschlandweit zugänglich</subfield><subfield code="3">Volltext</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_USEFLAG_U</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">ZDB-1-DJB</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_NL_ARTICLE</subfield></datafield><datafield tag="951" ind1=" " ind2=" "><subfield code="a">AR</subfield></datafield><datafield tag="952" ind1=" " ind2=" "><subfield code="d">11</subfield><subfield code="j">2003</subfield><subfield code="e">3</subfield><subfield code="h">0</subfield></datafield></record></collection>
|
| score |
7.400197 |