Detection and Significance of Occult Axillary Metastatic Disease in Breast Cancer Patients
▪ Abstract: After clinical staging, the single most important prognostic factor for patients with newly diagnosed primary breast cancer is the presence or absence of detectable metastases to axillary lymph nodes when examined by conventional light microscopy. More sensitive methods of determination...
Ausführliche Beschreibung
Gespeichert in:
| Autor*in: |
Siziopikou, Kalliopi P. - MD, PhD [verfasserIn] Schnitt, Stuart J. - MD [verfasserIn] Connolly, James L. - MD [verfasserIn] Hayes, Daniel F. - MD |
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| Format: |
E-Artikel |
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| Erschienen: |
Boston, MA, USA: Blackwell Science Inc ; 1999 |
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| Schlagwörter: |
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| Umfang: |
Online-Ressource |
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| Reproduktion: |
2002 ; Blackwell Publishing Journal Backfiles 1879-2005 |
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| Übergeordnetes Werk: |
In: The breast journal - Oxford [u.a.] : Wiley-Blackwell, 1995, 5(1999), 4, Seite 0 |
| Übergeordnetes Werk: |
volume:5 ; year:1999 ; number:4 ; pages:0 |
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| DOI / URN: |
10.1046/j.1524-4741.1999.99053.x |
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| 520 | |a ▪ Abstract: After clinical staging, the single most important prognostic factor for patients with newly diagnosed primary breast cancer is the presence or absence of detectable metastases to axillary lymph nodes when examined by conventional light microscopy. More sensitive methods of determination of lymph node status, such as evaluation of serial sections, immunohistochemical staining, and use of molecular biological assays increase the rate of detection of micrometastases. Although the feasibility of enhanced detection of occult axillary metastatic disease is well established, the prognostic significance of such detection is only recently starting to emerge. Furthermore, the enormous recent interest in the application of sentinel lymph node biopsy as an alternative to the evaluation of the entire axilla in patients with breast cancer makes the first-time detailed evaluation for micrometastases practically feasible. In this review the different methods of detecting micrometastatic disease in the axilla and the significance of such findings are discussed. ▪ | ||
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10.1046/j.1524-4741.1999.99053.x doi (DE-627)NLEJ24365720X DE-627 ger DE-627 rakwb Siziopikou, Kalliopi P. MD, PhD verfasserin aut Detection and Significance of Occult Axillary Metastatic Disease in Breast Cancer Patients Boston, MA, USA Blackwell Science Inc 1999 Online-Ressource nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier ▪ Abstract: After clinical staging, the single most important prognostic factor for patients with newly diagnosed primary breast cancer is the presence or absence of detectable metastases to axillary lymph nodes when examined by conventional light microscopy. More sensitive methods of determination of lymph node status, such as evaluation of serial sections, immunohistochemical staining, and use of molecular biological assays increase the rate of detection of micrometastases. Although the feasibility of enhanced detection of occult axillary metastatic disease is well established, the prognostic significance of such detection is only recently starting to emerge. Furthermore, the enormous recent interest in the application of sentinel lymph node biopsy as an alternative to the evaluation of the entire axilla in patients with breast cancer makes the first-time detailed evaluation for micrometastases practically feasible. In this review the different methods of detecting micrometastatic disease in the axilla and the significance of such findings are discussed. ▪ 2002 Blackwell Publishing Journal Backfiles 1879-2005 |2002|||||||||| axillary lymph nodes Schnitt, Stuart J. MD verfasserin aut Connolly, James L. MD verfasserin aut Hayes, Daniel F. MD oth In The breast journal Oxford [u.a.] : Wiley-Blackwell, 1995 5(1999), 4, Seite 0 Online-Ressource (DE-627)NLEJ243925794 (DE-600)2020959-9 1524-4741 nnns volume:5 year:1999 number:4 pages:0 http://dx.doi.org/10.1046/j.1524-4741.1999.99053.x text/html Verlag Deutschlandweit zugänglich Volltext GBV_USEFLAG_U ZDB-1-DJB GBV_NL_ARTICLE AR 5 1999 4 0 |
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10.1046/j.1524-4741.1999.99053.x doi (DE-627)NLEJ24365720X DE-627 ger DE-627 rakwb Siziopikou, Kalliopi P. MD, PhD verfasserin aut Detection and Significance of Occult Axillary Metastatic Disease in Breast Cancer Patients Boston, MA, USA Blackwell Science Inc 1999 Online-Ressource nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier ▪ Abstract: After clinical staging, the single most important prognostic factor for patients with newly diagnosed primary breast cancer is the presence or absence of detectable metastases to axillary lymph nodes when examined by conventional light microscopy. More sensitive methods of determination of lymph node status, such as evaluation of serial sections, immunohistochemical staining, and use of molecular biological assays increase the rate of detection of micrometastases. Although the feasibility of enhanced detection of occult axillary metastatic disease is well established, the prognostic significance of such detection is only recently starting to emerge. Furthermore, the enormous recent interest in the application of sentinel lymph node biopsy as an alternative to the evaluation of the entire axilla in patients with breast cancer makes the first-time detailed evaluation for micrometastases practically feasible. In this review the different methods of detecting micrometastatic disease in the axilla and the significance of such findings are discussed. ▪ 2002 Blackwell Publishing Journal Backfiles 1879-2005 |2002|||||||||| axillary lymph nodes Schnitt, Stuart J. MD verfasserin aut Connolly, James L. MD verfasserin aut Hayes, Daniel F. MD oth In The breast journal Oxford [u.a.] : Wiley-Blackwell, 1995 5(1999), 4, Seite 0 Online-Ressource (DE-627)NLEJ243925794 (DE-600)2020959-9 1524-4741 nnns volume:5 year:1999 number:4 pages:0 http://dx.doi.org/10.1046/j.1524-4741.1999.99053.x text/html Verlag Deutschlandweit zugänglich Volltext GBV_USEFLAG_U ZDB-1-DJB GBV_NL_ARTICLE AR 5 1999 4 0 |
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10.1046/j.1524-4741.1999.99053.x doi (DE-627)NLEJ24365720X DE-627 ger DE-627 rakwb Siziopikou, Kalliopi P. MD, PhD verfasserin aut Detection and Significance of Occult Axillary Metastatic Disease in Breast Cancer Patients Boston, MA, USA Blackwell Science Inc 1999 Online-Ressource nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier ▪ Abstract: After clinical staging, the single most important prognostic factor for patients with newly diagnosed primary breast cancer is the presence or absence of detectable metastases to axillary lymph nodes when examined by conventional light microscopy. More sensitive methods of determination of lymph node status, such as evaluation of serial sections, immunohistochemical staining, and use of molecular biological assays increase the rate of detection of micrometastases. Although the feasibility of enhanced detection of occult axillary metastatic disease is well established, the prognostic significance of such detection is only recently starting to emerge. Furthermore, the enormous recent interest in the application of sentinel lymph node biopsy as an alternative to the evaluation of the entire axilla in patients with breast cancer makes the first-time detailed evaluation for micrometastases practically feasible. In this review the different methods of detecting micrometastatic disease in the axilla and the significance of such findings are discussed. ▪ 2002 Blackwell Publishing Journal Backfiles 1879-2005 |2002|||||||||| axillary lymph nodes Schnitt, Stuart J. MD verfasserin aut Connolly, James L. MD verfasserin aut Hayes, Daniel F. MD oth In The breast journal Oxford [u.a.] : Wiley-Blackwell, 1995 5(1999), 4, Seite 0 Online-Ressource (DE-627)NLEJ243925794 (DE-600)2020959-9 1524-4741 nnns volume:5 year:1999 number:4 pages:0 http://dx.doi.org/10.1046/j.1524-4741.1999.99053.x text/html Verlag Deutschlandweit zugänglich Volltext GBV_USEFLAG_U ZDB-1-DJB GBV_NL_ARTICLE AR 5 1999 4 0 |
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10.1046/j.1524-4741.1999.99053.x doi (DE-627)NLEJ24365720X DE-627 ger DE-627 rakwb Siziopikou, Kalliopi P. MD, PhD verfasserin aut Detection and Significance of Occult Axillary Metastatic Disease in Breast Cancer Patients Boston, MA, USA Blackwell Science Inc 1999 Online-Ressource nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier ▪ Abstract: After clinical staging, the single most important prognostic factor for patients with newly diagnosed primary breast cancer is the presence or absence of detectable metastases to axillary lymph nodes when examined by conventional light microscopy. More sensitive methods of determination of lymph node status, such as evaluation of serial sections, immunohistochemical staining, and use of molecular biological assays increase the rate of detection of micrometastases. Although the feasibility of enhanced detection of occult axillary metastatic disease is well established, the prognostic significance of such detection is only recently starting to emerge. Furthermore, the enormous recent interest in the application of sentinel lymph node biopsy as an alternative to the evaluation of the entire axilla in patients with breast cancer makes the first-time detailed evaluation for micrometastases practically feasible. In this review the different methods of detecting micrometastatic disease in the axilla and the significance of such findings are discussed. ▪ 2002 Blackwell Publishing Journal Backfiles 1879-2005 |2002|||||||||| axillary lymph nodes Schnitt, Stuart J. MD verfasserin aut Connolly, James L. MD verfasserin aut Hayes, Daniel F. MD oth In The breast journal Oxford [u.a.] : Wiley-Blackwell, 1995 5(1999), 4, Seite 0 Online-Ressource (DE-627)NLEJ243925794 (DE-600)2020959-9 1524-4741 nnns volume:5 year:1999 number:4 pages:0 http://dx.doi.org/10.1046/j.1524-4741.1999.99053.x text/html Verlag Deutschlandweit zugänglich Volltext GBV_USEFLAG_U ZDB-1-DJB GBV_NL_ARTICLE AR 5 1999 4 0 |
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▪ Abstract: After clinical staging, the single most important prognostic factor for patients with newly diagnosed primary breast cancer is the presence or absence of detectable metastases to axillary lymph nodes when examined by conventional light microscopy. More sensitive methods of determination of lymph node status, such as evaluation of serial sections, immunohistochemical staining, and use of molecular biological assays increase the rate of detection of micrometastases. Although the feasibility of enhanced detection of occult axillary metastatic disease is well established, the prognostic significance of such detection is only recently starting to emerge. Furthermore, the enormous recent interest in the application of sentinel lymph node biopsy as an alternative to the evaluation of the entire axilla in patients with breast cancer makes the first-time detailed evaluation for micrometastases practically feasible. In this review the different methods of detecting micrometastatic disease in the axilla and the significance of such findings are discussed. ▪ |
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▪ Abstract: After clinical staging, the single most important prognostic factor for patients with newly diagnosed primary breast cancer is the presence or absence of detectable metastases to axillary lymph nodes when examined by conventional light microscopy. More sensitive methods of determination of lymph node status, such as evaluation of serial sections, immunohistochemical staining, and use of molecular biological assays increase the rate of detection of micrometastases. Although the feasibility of enhanced detection of occult axillary metastatic disease is well established, the prognostic significance of such detection is only recently starting to emerge. Furthermore, the enormous recent interest in the application of sentinel lymph node biopsy as an alternative to the evaluation of the entire axilla in patients with breast cancer makes the first-time detailed evaluation for micrometastases practically feasible. In this review the different methods of detecting micrometastatic disease in the axilla and the significance of such findings are discussed. ▪ |
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▪ Abstract: After clinical staging, the single most important prognostic factor for patients with newly diagnosed primary breast cancer is the presence or absence of detectable metastases to axillary lymph nodes when examined by conventional light microscopy. More sensitive methods of determination of lymph node status, such as evaluation of serial sections, immunohistochemical staining, and use of molecular biological assays increase the rate of detection of micrometastases. Although the feasibility of enhanced detection of occult axillary metastatic disease is well established, the prognostic significance of such detection is only recently starting to emerge. Furthermore, the enormous recent interest in the application of sentinel lymph node biopsy as an alternative to the evaluation of the entire axilla in patients with breast cancer makes the first-time detailed evaluation for micrometastases practically feasible. In this review the different methods of detecting micrometastatic disease in the axilla and the significance of such findings are discussed. ▪ |
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<?xml version="1.0" encoding="UTF-8"?><collection xmlns="http://www.loc.gov/MARC21/slim"><record><leader>01000caa a22002652 4500</leader><controlfield tag="001">NLEJ24365720X</controlfield><controlfield tag="003">DE-627</controlfield><controlfield tag="005">20230505213035.0</controlfield><controlfield tag="007">cr uuu---uuuuu</controlfield><controlfield tag="008">120427s1999 xx |||||o 00| ||und c</controlfield><datafield tag="024" ind1="7" ind2=" "><subfield code="a">10.1046/j.1524-4741.1999.99053.x</subfield><subfield code="2">doi</subfield></datafield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(DE-627)NLEJ24365720X</subfield></datafield><datafield tag="040" ind1=" " ind2=" "><subfield code="a">DE-627</subfield><subfield code="b">ger</subfield><subfield code="c">DE-627</subfield><subfield code="e">rakwb</subfield></datafield><datafield tag="100" ind1="1" ind2=" "><subfield code="a">Siziopikou, Kalliopi P.</subfield><subfield code="c">MD, PhD</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="245" ind1="1" ind2="0"><subfield code="a">Detection and Significance of Occult Axillary Metastatic Disease in Breast Cancer Patients</subfield></datafield><datafield tag="264" ind1=" " ind2="1"><subfield code="a">Boston, MA, USA</subfield><subfield code="b">Blackwell Science Inc</subfield><subfield code="c">1999</subfield></datafield><datafield tag="300" ind1=" " ind2=" "><subfield code="a">Online-Ressource</subfield></datafield><datafield tag="336" ind1=" " ind2=" "><subfield code="a">nicht spezifiziert</subfield><subfield code="b">zzz</subfield><subfield code="2">rdacontent</subfield></datafield><datafield tag="337" ind1=" " ind2=" "><subfield code="a">nicht spezifiziert</subfield><subfield code="b">z</subfield><subfield code="2">rdamedia</subfield></datafield><datafield tag="338" ind1=" " ind2=" "><subfield code="a">nicht spezifiziert</subfield><subfield code="b">zu</subfield><subfield code="2">rdacarrier</subfield></datafield><datafield tag="520" ind1=" " ind2=" "><subfield code="a">▪ Abstract: After clinical staging, the single most important prognostic factor for patients with newly diagnosed primary breast cancer is the presence or absence of detectable metastases to axillary lymph nodes when examined by conventional light microscopy. More sensitive methods of determination of lymph node status, such as evaluation of serial sections, immunohistochemical staining, and use of molecular biological assays increase the rate of detection of micrometastases. Although the feasibility of enhanced detection of occult axillary metastatic disease is well established, the prognostic significance of such detection is only recently starting to emerge. Furthermore, the enormous recent interest in the application of sentinel lymph node biopsy as an alternative to the evaluation of the entire axilla in patients with breast cancer makes the first-time detailed evaluation for micrometastases practically feasible. 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7.4007263 |