Multiple Mycobacterium microti Derived Lipids Stimulate iNOS Gene Expression in the J774 Murine Macrophage Cell Line
The inducible nitrogen oxygen synthase (iNOS) and nitric oxide (NO) system acting in concert with superoxide radicals is recognized as a powerful macrophage microbicidal mechanism. However, experimentation with iNOS knockout mice has rendered contradictory results on the protective role of iNOS/NO i...
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| Autor*in: |
Pacheco-García, U. [verfasserIn] Legorreta-HerrEra, M. [verfasserIn] Hernández-Rodríguez, C. [verfasserIn] |
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| Format: |
E-Artikel |
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| Erschienen: |
Oxford, UK: Blackwell Science Ltd ; 2002 |
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| Umfang: |
Online-Ressource |
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| Reproduktion: |
2002 ; Blackwell Publishing Journal Backfiles 1879-2005 |
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| Übergeordnetes Werk: |
In: Scandinavian journal of immunology - Oxford [u.a.] : Wiley-Blackwell, 1972, 56(2002), 1, Seite 0 |
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volume:56 ; year:2002 ; number:1 ; pages:0 |
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| DOI / URN: |
10.1046/j.1365-3083.2002.01103.x |
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| 520 | |a The inducible nitrogen oxygen synthase (iNOS) and nitric oxide (NO) system acting in concert with superoxide radicals is recognized as a powerful macrophage microbicidal mechanism. However, experimentation with iNOS knockout mice has rendered contradictory results on the protective role of iNOS/NO in the course of mycobacterial infections. On the other hand, NO also plays an immunoregulatory role. Knowing the nature of the mycobacterial constituents that induce iNOS gene expression would help to better understand the host–parasite relationship.Lipoarabinomannan (LAM) and a 19 KDa lipoprotein are the two known mycobacterial constituents that have shown to induce iNOS. By screening a set of methanol extracted lipids from Mycobacterium microti, here we provide evidence that multiple mycobacterial molecules of lipidic nature both of intermediate and of high polarity, with free amino groups or carbohydrates but no phosphate groups as part of their structure are capable of inducing iNOS gene expression in J774 cells, thus implying a complex relationship between mycobacteria and their host immune system in regard to iNOS gene expression. | ||
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10.1046/j.1365-3083.2002.01103.x doi (DE-627)NLEJ243701136 DE-627 ger DE-627 rakwb Pacheco-García, U. verfasserin aut Multiple Mycobacterium microti Derived Lipids Stimulate iNOS Gene Expression in the J774 Murine Macrophage Cell Line Oxford, UK Blackwell Science Ltd 2002 Online-Ressource nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier The inducible nitrogen oxygen synthase (iNOS) and nitric oxide (NO) system acting in concert with superoxide radicals is recognized as a powerful macrophage microbicidal mechanism. However, experimentation with iNOS knockout mice has rendered contradictory results on the protective role of iNOS/NO in the course of mycobacterial infections. On the other hand, NO also plays an immunoregulatory role. Knowing the nature of the mycobacterial constituents that induce iNOS gene expression would help to better understand the host–parasite relationship.Lipoarabinomannan (LAM) and a 19 KDa lipoprotein are the two known mycobacterial constituents that have shown to induce iNOS. By screening a set of methanol extracted lipids from Mycobacterium microti, here we provide evidence that multiple mycobacterial molecules of lipidic nature both of intermediate and of high polarity, with free amino groups or carbohydrates but no phosphate groups as part of their structure are capable of inducing iNOS gene expression in J774 cells, thus implying a complex relationship between mycobacteria and their host immune system in regard to iNOS gene expression. 2002 Blackwell Publishing Journal Backfiles 1879-2005 |2002|||||||||| Legorreta-HerrEra, M. verfasserin aut Hernández-Rodríguez, C. verfasserin aut Sánchez-García, F. J. oth In Scandinavian journal of immunology Oxford [u.a.] : Wiley-Blackwell, 1972 56(2002), 1, Seite 0 Online-Ressource (DE-627)NLEJ24392724X (DE-600)2020954-X 1365-3083 nnns volume:56 year:2002 number:1 pages:0 http://dx.doi.org/10.1046/j.1365-3083.2002.01103.x text/html Verlag Deutschlandweit zugänglich Volltext GBV_USEFLAG_U ZDB-1-DJB GBV_NL_ARTICLE AR 56 2002 1 0 |
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10.1046/j.1365-3083.2002.01103.x doi (DE-627)NLEJ243701136 DE-627 ger DE-627 rakwb Pacheco-García, U. verfasserin aut Multiple Mycobacterium microti Derived Lipids Stimulate iNOS Gene Expression in the J774 Murine Macrophage Cell Line Oxford, UK Blackwell Science Ltd 2002 Online-Ressource nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier The inducible nitrogen oxygen synthase (iNOS) and nitric oxide (NO) system acting in concert with superoxide radicals is recognized as a powerful macrophage microbicidal mechanism. However, experimentation with iNOS knockout mice has rendered contradictory results on the protective role of iNOS/NO in the course of mycobacterial infections. On the other hand, NO also plays an immunoregulatory role. Knowing the nature of the mycobacterial constituents that induce iNOS gene expression would help to better understand the host–parasite relationship.Lipoarabinomannan (LAM) and a 19 KDa lipoprotein are the two known mycobacterial constituents that have shown to induce iNOS. By screening a set of methanol extracted lipids from Mycobacterium microti, here we provide evidence that multiple mycobacterial molecules of lipidic nature both of intermediate and of high polarity, with free amino groups or carbohydrates but no phosphate groups as part of their structure are capable of inducing iNOS gene expression in J774 cells, thus implying a complex relationship between mycobacteria and their host immune system in regard to iNOS gene expression. 2002 Blackwell Publishing Journal Backfiles 1879-2005 |2002|||||||||| Legorreta-HerrEra, M. verfasserin aut Hernández-Rodríguez, C. verfasserin aut Sánchez-García, F. J. oth In Scandinavian journal of immunology Oxford [u.a.] : Wiley-Blackwell, 1972 56(2002), 1, Seite 0 Online-Ressource (DE-627)NLEJ24392724X (DE-600)2020954-X 1365-3083 nnns volume:56 year:2002 number:1 pages:0 http://dx.doi.org/10.1046/j.1365-3083.2002.01103.x text/html Verlag Deutschlandweit zugänglich Volltext GBV_USEFLAG_U ZDB-1-DJB GBV_NL_ARTICLE AR 56 2002 1 0 |
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10.1046/j.1365-3083.2002.01103.x doi (DE-627)NLEJ243701136 DE-627 ger DE-627 rakwb Pacheco-García, U. verfasserin aut Multiple Mycobacterium microti Derived Lipids Stimulate iNOS Gene Expression in the J774 Murine Macrophage Cell Line Oxford, UK Blackwell Science Ltd 2002 Online-Ressource nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier The inducible nitrogen oxygen synthase (iNOS) and nitric oxide (NO) system acting in concert with superoxide radicals is recognized as a powerful macrophage microbicidal mechanism. However, experimentation with iNOS knockout mice has rendered contradictory results on the protective role of iNOS/NO in the course of mycobacterial infections. On the other hand, NO also plays an immunoregulatory role. Knowing the nature of the mycobacterial constituents that induce iNOS gene expression would help to better understand the host–parasite relationship.Lipoarabinomannan (LAM) and a 19 KDa lipoprotein are the two known mycobacterial constituents that have shown to induce iNOS. By screening a set of methanol extracted lipids from Mycobacterium microti, here we provide evidence that multiple mycobacterial molecules of lipidic nature both of intermediate and of high polarity, with free amino groups or carbohydrates but no phosphate groups as part of their structure are capable of inducing iNOS gene expression in J774 cells, thus implying a complex relationship between mycobacteria and their host immune system in regard to iNOS gene expression. 2002 Blackwell Publishing Journal Backfiles 1879-2005 |2002|||||||||| Legorreta-HerrEra, M. verfasserin aut Hernández-Rodríguez, C. verfasserin aut Sánchez-García, F. J. oth In Scandinavian journal of immunology Oxford [u.a.] : Wiley-Blackwell, 1972 56(2002), 1, Seite 0 Online-Ressource (DE-627)NLEJ24392724X (DE-600)2020954-X 1365-3083 nnns volume:56 year:2002 number:1 pages:0 http://dx.doi.org/10.1046/j.1365-3083.2002.01103.x text/html Verlag Deutschlandweit zugänglich Volltext GBV_USEFLAG_U ZDB-1-DJB GBV_NL_ARTICLE AR 56 2002 1 0 |
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10.1046/j.1365-3083.2002.01103.x doi (DE-627)NLEJ243701136 DE-627 ger DE-627 rakwb Pacheco-García, U. verfasserin aut Multiple Mycobacterium microti Derived Lipids Stimulate iNOS Gene Expression in the J774 Murine Macrophage Cell Line Oxford, UK Blackwell Science Ltd 2002 Online-Ressource nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier The inducible nitrogen oxygen synthase (iNOS) and nitric oxide (NO) system acting in concert with superoxide radicals is recognized as a powerful macrophage microbicidal mechanism. However, experimentation with iNOS knockout mice has rendered contradictory results on the protective role of iNOS/NO in the course of mycobacterial infections. On the other hand, NO also plays an immunoregulatory role. Knowing the nature of the mycobacterial constituents that induce iNOS gene expression would help to better understand the host–parasite relationship.Lipoarabinomannan (LAM) and a 19 KDa lipoprotein are the two known mycobacterial constituents that have shown to induce iNOS. By screening a set of methanol extracted lipids from Mycobacterium microti, here we provide evidence that multiple mycobacterial molecules of lipidic nature both of intermediate and of high polarity, with free amino groups or carbohydrates but no phosphate groups as part of their structure are capable of inducing iNOS gene expression in J774 cells, thus implying a complex relationship between mycobacteria and their host immune system in regard to iNOS gene expression. 2002 Blackwell Publishing Journal Backfiles 1879-2005 |2002|||||||||| Legorreta-HerrEra, M. verfasserin aut Hernández-Rodríguez, C. verfasserin aut Sánchez-García, F. J. oth In Scandinavian journal of immunology Oxford [u.a.] : Wiley-Blackwell, 1972 56(2002), 1, Seite 0 Online-Ressource (DE-627)NLEJ24392724X (DE-600)2020954-X 1365-3083 nnns volume:56 year:2002 number:1 pages:0 http://dx.doi.org/10.1046/j.1365-3083.2002.01103.x text/html Verlag Deutschlandweit zugänglich Volltext GBV_USEFLAG_U ZDB-1-DJB GBV_NL_ARTICLE AR 56 2002 1 0 |
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10.1046/j.1365-3083.2002.01103.x doi (DE-627)NLEJ243701136 DE-627 ger DE-627 rakwb Pacheco-García, U. verfasserin aut Multiple Mycobacterium microti Derived Lipids Stimulate iNOS Gene Expression in the J774 Murine Macrophage Cell Line Oxford, UK Blackwell Science Ltd 2002 Online-Ressource nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier The inducible nitrogen oxygen synthase (iNOS) and nitric oxide (NO) system acting in concert with superoxide radicals is recognized as a powerful macrophage microbicidal mechanism. However, experimentation with iNOS knockout mice has rendered contradictory results on the protective role of iNOS/NO in the course of mycobacterial infections. On the other hand, NO also plays an immunoregulatory role. Knowing the nature of the mycobacterial constituents that induce iNOS gene expression would help to better understand the host–parasite relationship.Lipoarabinomannan (LAM) and a 19 KDa lipoprotein are the two known mycobacterial constituents that have shown to induce iNOS. By screening a set of methanol extracted lipids from Mycobacterium microti, here we provide evidence that multiple mycobacterial molecules of lipidic nature both of intermediate and of high polarity, with free amino groups or carbohydrates but no phosphate groups as part of their structure are capable of inducing iNOS gene expression in J774 cells, thus implying a complex relationship between mycobacteria and their host immune system in regard to iNOS gene expression. 2002 Blackwell Publishing Journal Backfiles 1879-2005 |2002|||||||||| Legorreta-HerrEra, M. verfasserin aut Hernández-Rodríguez, C. verfasserin aut Sánchez-García, F. J. oth In Scandinavian journal of immunology Oxford [u.a.] : Wiley-Blackwell, 1972 56(2002), 1, Seite 0 Online-Ressource (DE-627)NLEJ24392724X (DE-600)2020954-X 1365-3083 nnns volume:56 year:2002 number:1 pages:0 http://dx.doi.org/10.1046/j.1365-3083.2002.01103.x text/html Verlag Deutschlandweit zugänglich Volltext GBV_USEFLAG_U ZDB-1-DJB GBV_NL_ARTICLE AR 56 2002 1 0 |
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Multiple Mycobacterium microti Derived Lipids Stimulate iNOS Gene Expression in the J774 Murine Macrophage Cell Line |
| abstract |
The inducible nitrogen oxygen synthase (iNOS) and nitric oxide (NO) system acting in concert with superoxide radicals is recognized as a powerful macrophage microbicidal mechanism. However, experimentation with iNOS knockout mice has rendered contradictory results on the protective role of iNOS/NO in the course of mycobacterial infections. On the other hand, NO also plays an immunoregulatory role. Knowing the nature of the mycobacterial constituents that induce iNOS gene expression would help to better understand the host–parasite relationship.Lipoarabinomannan (LAM) and a 19 KDa lipoprotein are the two known mycobacterial constituents that have shown to induce iNOS. By screening a set of methanol extracted lipids from Mycobacterium microti, here we provide evidence that multiple mycobacterial molecules of lipidic nature both of intermediate and of high polarity, with free amino groups or carbohydrates but no phosphate groups as part of their structure are capable of inducing iNOS gene expression in J774 cells, thus implying a complex relationship between mycobacteria and their host immune system in regard to iNOS gene expression. |
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The inducible nitrogen oxygen synthase (iNOS) and nitric oxide (NO) system acting in concert with superoxide radicals is recognized as a powerful macrophage microbicidal mechanism. However, experimentation with iNOS knockout mice has rendered contradictory results on the protective role of iNOS/NO in the course of mycobacterial infections. On the other hand, NO also plays an immunoregulatory role. Knowing the nature of the mycobacterial constituents that induce iNOS gene expression would help to better understand the host–parasite relationship.Lipoarabinomannan (LAM) and a 19 KDa lipoprotein are the two known mycobacterial constituents that have shown to induce iNOS. By screening a set of methanol extracted lipids from Mycobacterium microti, here we provide evidence that multiple mycobacterial molecules of lipidic nature both of intermediate and of high polarity, with free amino groups or carbohydrates but no phosphate groups as part of their structure are capable of inducing iNOS gene expression in J774 cells, thus implying a complex relationship between mycobacteria and their host immune system in regard to iNOS gene expression. |
| abstract_unstemmed |
The inducible nitrogen oxygen synthase (iNOS) and nitric oxide (NO) system acting in concert with superoxide radicals is recognized as a powerful macrophage microbicidal mechanism. However, experimentation with iNOS knockout mice has rendered contradictory results on the protective role of iNOS/NO in the course of mycobacterial infections. On the other hand, NO also plays an immunoregulatory role. Knowing the nature of the mycobacterial constituents that induce iNOS gene expression would help to better understand the host–parasite relationship.Lipoarabinomannan (LAM) and a 19 KDa lipoprotein are the two known mycobacterial constituents that have shown to induce iNOS. By screening a set of methanol extracted lipids from Mycobacterium microti, here we provide evidence that multiple mycobacterial molecules of lipidic nature both of intermediate and of high polarity, with free amino groups or carbohydrates but no phosphate groups as part of their structure are capable of inducing iNOS gene expression in J774 cells, thus implying a complex relationship between mycobacteria and their host immune system in regard to iNOS gene expression. |
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Legorreta-HerrEra, M. Hernández-Rodríguez, C. Sánchez-García, F. J. |
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Legorreta-HerrEra, M. Hernández-Rodríguez, C. Sánchez-García, F. J. |
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NLEJ24392724X |
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oth |
| doi_str |
10.1046/j.1365-3083.2002.01103.x |
| up_date |
2024-07-06T06:16:24.175Z |
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1803809282248933376 |
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By screening a set of methanol extracted lipids from Mycobacterium microti, here we provide evidence that multiple mycobacterial molecules of lipidic nature both of intermediate and of high polarity, with free amino groups or carbohydrates but no phosphate groups as part of their structure are capable of inducing iNOS gene expression in J774 cells, thus implying a complex relationship between mycobacteria and their host immune system in regard to iNOS gene expression.</subfield></datafield><datafield tag="533" ind1=" " ind2=" "><subfield code="d">2002</subfield><subfield code="f">Blackwell Publishing Journal Backfiles 1879-2005</subfield><subfield code="7">|2002||||||||||</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Legorreta-HerrEra, M.</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Hernández-Rodríguez, C.</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Sánchez-García, F. 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7.399083 |