Assessing Human Health Response in Life Cycle Assessment Using ED10s and DALYs: Part 1—Cancer Effects
Life cycle assessment (LCA) is a framework for comparing products according to their total estimated environmental impact, summed over all chemical emissions and activities associated with a product at all stages in its life cycle (from raw material acquisition, manufacturing, use, to final disposal...
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| Autor*in: |
Crettaz, Pierre [verfasserIn] Pennington, David [verfasserIn] Rhomberg, Lorenz [verfasserIn] |
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| Format: |
E-Artikel |
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| Erschienen: |
350 Main Street , Malden , MA 02148 , USA , and 108 Cowley Road , Oxford OX4 1JF , UK .: Blackwell Publishing ; 2002 |
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Online-Ressource |
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| Reproduktion: |
2008 ; Blackwell Publishing Journal Backfiles 1879-2005 |
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| Übergeordnetes Werk: |
In: Risk analysis - Oxford [u.a.] : Wiley-Blackwell, 1981, 22(2002), 5, Seite 0 |
| Übergeordnetes Werk: |
volume:22 ; year:2002 ; number:5 ; pages:0 |
| Links: |
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| DOI / URN: |
10.1111/1539-6924.00262 |
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NLEJ243730527 |
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| 520 | |a Life cycle assessment (LCA) is a framework for comparing products according to their total estimated environmental impact, summed over all chemical emissions and activities associated with a product at all stages in its life cycle (from raw material acquisition, manufacturing, use, to final disposal). For each chemical involved, the exposure associated with the mass released into the environment, integrated over time and space, is multiplied by a toxicological measure to estimate the likelihood of effects and their potential consequences. In this article, we explore the use of quantitative methods drawn from conventional single-chemical regulatory risk assessments to create a procedure for the estimation of the cancer effect measure in the impact phase of LCA. The approach is based on the maximum likelihood estimate of the effect dose inducing a 10% response over background, ED10, and default linear low-dose extrapolation using the slope βED10 (0.1/ED10). The calculated effects may correspond to residual risks below current regulatory compliance requirements that occur over multiple generations and at multiple locations; but at the very least they represent a “using up” of some portion of the human population's ability to accommodate emissions. Preliminary comparisons are performed with existing measures, such as the U.S. Environmental Protection Agency's (U.S. EPA's) slope factor measure q1*. By analyzing bioassay data for 44 chemicals drawn from the EPA's Integrated Risk Information System (IRIS) database, we explore estimating ED10 from more readily available information such as the median tumor dose rate TD50 and the median single lethal dose LD50. Based on the TD50, we then estimate the ED10 for more than 600 chemicals. Differences in potential consequences, or severity, are addressed by combining βED10 with the measure disability adjusted life years per affected person, DALYp. Most of the variation among chemicals for cancer effects is found to be due to differences in the slope factors (βED10) ranging from 10−4 up to 104 (risk of cancer/mg/kg-day). | ||
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10.1111/1539-6924.00262 doi (DE-627)NLEJ243730527 DE-627 ger DE-627 rakwb Crettaz, Pierre verfasserin aut Assessing Human Health Response in Life Cycle Assessment Using ED10s and DALYs: Part 1—Cancer Effects 350 Main Street , Malden , MA 02148 , USA , and 108 Cowley Road , Oxford OX4 1JF , UK . Blackwell Publishing 2002 Online-Ressource nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Life cycle assessment (LCA) is a framework for comparing products according to their total estimated environmental impact, summed over all chemical emissions and activities associated with a product at all stages in its life cycle (from raw material acquisition, manufacturing, use, to final disposal). For each chemical involved, the exposure associated with the mass released into the environment, integrated over time and space, is multiplied by a toxicological measure to estimate the likelihood of effects and their potential consequences. In this article, we explore the use of quantitative methods drawn from conventional single-chemical regulatory risk assessments to create a procedure for the estimation of the cancer effect measure in the impact phase of LCA. The approach is based on the maximum likelihood estimate of the effect dose inducing a 10% response over background, ED10, and default linear low-dose extrapolation using the slope βED10 (0.1/ED10). The calculated effects may correspond to residual risks below current regulatory compliance requirements that occur over multiple generations and at multiple locations; but at the very least they represent a “using up” of some portion of the human population's ability to accommodate emissions. Preliminary comparisons are performed with existing measures, such as the U.S. Environmental Protection Agency's (U.S. EPA's) slope factor measure q1*. By analyzing bioassay data for 44 chemicals drawn from the EPA's Integrated Risk Information System (IRIS) database, we explore estimating ED10 from more readily available information such as the median tumor dose rate TD50 and the median single lethal dose LD50. Based on the TD50, we then estimate the ED10 for more than 600 chemicals. Differences in potential consequences, or severity, are addressed by combining βED10 with the measure disability adjusted life years per affected person, DALYp. Most of the variation among chemicals for cancer effects is found to be due to differences in the slope factors (βED10) ranging from 10−4 up to 104 (risk of cancer/mg/kg-day). 2008 Blackwell Publishing Journal Backfiles 1879-2005 |2008|||||||||| Life cycle impact assessment (LCA) Pennington, David verfasserin aut Rhomberg, Lorenz verfasserin aut Brand, Kevin oth Jolliet, Olivier oth In Risk analysis Oxford [u.a.] : Wiley-Blackwell, 1981 22(2002), 5, Seite 0 Online-Ressource (DE-627)NLEJ243926847 (DE-600)2001458-2 1539-6924 nnns volume:22 year:2002 number:5 pages:0 http://dx.doi.org/10.1111/1539-6924.00262 text/html Verlag Deutschlandweit zugänglich Volltext GBV_USEFLAG_U ZDB-1-DJB GBV_NL_ARTICLE AR 22 2002 5 0 |
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10.1111/1539-6924.00262 doi (DE-627)NLEJ243730527 DE-627 ger DE-627 rakwb Crettaz, Pierre verfasserin aut Assessing Human Health Response in Life Cycle Assessment Using ED10s and DALYs: Part 1—Cancer Effects 350 Main Street , Malden , MA 02148 , USA , and 108 Cowley Road , Oxford OX4 1JF , UK . Blackwell Publishing 2002 Online-Ressource nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Life cycle assessment (LCA) is a framework for comparing products according to their total estimated environmental impact, summed over all chemical emissions and activities associated with a product at all stages in its life cycle (from raw material acquisition, manufacturing, use, to final disposal). For each chemical involved, the exposure associated with the mass released into the environment, integrated over time and space, is multiplied by a toxicological measure to estimate the likelihood of effects and their potential consequences. In this article, we explore the use of quantitative methods drawn from conventional single-chemical regulatory risk assessments to create a procedure for the estimation of the cancer effect measure in the impact phase of LCA. The approach is based on the maximum likelihood estimate of the effect dose inducing a 10% response over background, ED10, and default linear low-dose extrapolation using the slope βED10 (0.1/ED10). The calculated effects may correspond to residual risks below current regulatory compliance requirements that occur over multiple generations and at multiple locations; but at the very least they represent a “using up” of some portion of the human population's ability to accommodate emissions. Preliminary comparisons are performed with existing measures, such as the U.S. Environmental Protection Agency's (U.S. EPA's) slope factor measure q1*. By analyzing bioassay data for 44 chemicals drawn from the EPA's Integrated Risk Information System (IRIS) database, we explore estimating ED10 from more readily available information such as the median tumor dose rate TD50 and the median single lethal dose LD50. Based on the TD50, we then estimate the ED10 for more than 600 chemicals. Differences in potential consequences, or severity, are addressed by combining βED10 with the measure disability adjusted life years per affected person, DALYp. Most of the variation among chemicals for cancer effects is found to be due to differences in the slope factors (βED10) ranging from 10−4 up to 104 (risk of cancer/mg/kg-day). 2008 Blackwell Publishing Journal Backfiles 1879-2005 |2008|||||||||| Life cycle impact assessment (LCA) Pennington, David verfasserin aut Rhomberg, Lorenz verfasserin aut Brand, Kevin oth Jolliet, Olivier oth In Risk analysis Oxford [u.a.] : Wiley-Blackwell, 1981 22(2002), 5, Seite 0 Online-Ressource (DE-627)NLEJ243926847 (DE-600)2001458-2 1539-6924 nnns volume:22 year:2002 number:5 pages:0 http://dx.doi.org/10.1111/1539-6924.00262 text/html Verlag Deutschlandweit zugänglich Volltext GBV_USEFLAG_U ZDB-1-DJB GBV_NL_ARTICLE AR 22 2002 5 0 |
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10.1111/1539-6924.00262 doi (DE-627)NLEJ243730527 DE-627 ger DE-627 rakwb Crettaz, Pierre verfasserin aut Assessing Human Health Response in Life Cycle Assessment Using ED10s and DALYs: Part 1—Cancer Effects 350 Main Street , Malden , MA 02148 , USA , and 108 Cowley Road , Oxford OX4 1JF , UK . Blackwell Publishing 2002 Online-Ressource nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Life cycle assessment (LCA) is a framework for comparing products according to their total estimated environmental impact, summed over all chemical emissions and activities associated with a product at all stages in its life cycle (from raw material acquisition, manufacturing, use, to final disposal). For each chemical involved, the exposure associated with the mass released into the environment, integrated over time and space, is multiplied by a toxicological measure to estimate the likelihood of effects and their potential consequences. In this article, we explore the use of quantitative methods drawn from conventional single-chemical regulatory risk assessments to create a procedure for the estimation of the cancer effect measure in the impact phase of LCA. The approach is based on the maximum likelihood estimate of the effect dose inducing a 10% response over background, ED10, and default linear low-dose extrapolation using the slope βED10 (0.1/ED10). The calculated effects may correspond to residual risks below current regulatory compliance requirements that occur over multiple generations and at multiple locations; but at the very least they represent a “using up” of some portion of the human population's ability to accommodate emissions. Preliminary comparisons are performed with existing measures, such as the U.S. Environmental Protection Agency's (U.S. EPA's) slope factor measure q1*. By analyzing bioassay data for 44 chemicals drawn from the EPA's Integrated Risk Information System (IRIS) database, we explore estimating ED10 from more readily available information such as the median tumor dose rate TD50 and the median single lethal dose LD50. Based on the TD50, we then estimate the ED10 for more than 600 chemicals. Differences in potential consequences, or severity, are addressed by combining βED10 with the measure disability adjusted life years per affected person, DALYp. Most of the variation among chemicals for cancer effects is found to be due to differences in the slope factors (βED10) ranging from 10−4 up to 104 (risk of cancer/mg/kg-day). 2008 Blackwell Publishing Journal Backfiles 1879-2005 |2008|||||||||| Life cycle impact assessment (LCA) Pennington, David verfasserin aut Rhomberg, Lorenz verfasserin aut Brand, Kevin oth Jolliet, Olivier oth In Risk analysis Oxford [u.a.] : Wiley-Blackwell, 1981 22(2002), 5, Seite 0 Online-Ressource (DE-627)NLEJ243926847 (DE-600)2001458-2 1539-6924 nnns volume:22 year:2002 number:5 pages:0 http://dx.doi.org/10.1111/1539-6924.00262 text/html Verlag Deutschlandweit zugänglich Volltext GBV_USEFLAG_U ZDB-1-DJB GBV_NL_ARTICLE AR 22 2002 5 0 |
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10.1111/1539-6924.00262 doi (DE-627)NLEJ243730527 DE-627 ger DE-627 rakwb Crettaz, Pierre verfasserin aut Assessing Human Health Response in Life Cycle Assessment Using ED10s and DALYs: Part 1—Cancer Effects 350 Main Street , Malden , MA 02148 , USA , and 108 Cowley Road , Oxford OX4 1JF , UK . Blackwell Publishing 2002 Online-Ressource nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Life cycle assessment (LCA) is a framework for comparing products according to their total estimated environmental impact, summed over all chemical emissions and activities associated with a product at all stages in its life cycle (from raw material acquisition, manufacturing, use, to final disposal). For each chemical involved, the exposure associated with the mass released into the environment, integrated over time and space, is multiplied by a toxicological measure to estimate the likelihood of effects and their potential consequences. In this article, we explore the use of quantitative methods drawn from conventional single-chemical regulatory risk assessments to create a procedure for the estimation of the cancer effect measure in the impact phase of LCA. The approach is based on the maximum likelihood estimate of the effect dose inducing a 10% response over background, ED10, and default linear low-dose extrapolation using the slope βED10 (0.1/ED10). The calculated effects may correspond to residual risks below current regulatory compliance requirements that occur over multiple generations and at multiple locations; but at the very least they represent a “using up” of some portion of the human population's ability to accommodate emissions. Preliminary comparisons are performed with existing measures, such as the U.S. Environmental Protection Agency's (U.S. EPA's) slope factor measure q1*. By analyzing bioassay data for 44 chemicals drawn from the EPA's Integrated Risk Information System (IRIS) database, we explore estimating ED10 from more readily available information such as the median tumor dose rate TD50 and the median single lethal dose LD50. Based on the TD50, we then estimate the ED10 for more than 600 chemicals. Differences in potential consequences, or severity, are addressed by combining βED10 with the measure disability adjusted life years per affected person, DALYp. Most of the variation among chemicals for cancer effects is found to be due to differences in the slope factors (βED10) ranging from 10−4 up to 104 (risk of cancer/mg/kg-day). 2008 Blackwell Publishing Journal Backfiles 1879-2005 |2008|||||||||| Life cycle impact assessment (LCA) Pennington, David verfasserin aut Rhomberg, Lorenz verfasserin aut Brand, Kevin oth Jolliet, Olivier oth In Risk analysis Oxford [u.a.] : Wiley-Blackwell, 1981 22(2002), 5, Seite 0 Online-Ressource (DE-627)NLEJ243926847 (DE-600)2001458-2 1539-6924 nnns volume:22 year:2002 number:5 pages:0 http://dx.doi.org/10.1111/1539-6924.00262 text/html Verlag Deutschlandweit zugänglich Volltext GBV_USEFLAG_U ZDB-1-DJB GBV_NL_ARTICLE AR 22 2002 5 0 |
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10.1111/1539-6924.00262 doi (DE-627)NLEJ243730527 DE-627 ger DE-627 rakwb Crettaz, Pierre verfasserin aut Assessing Human Health Response in Life Cycle Assessment Using ED10s and DALYs: Part 1—Cancer Effects 350 Main Street , Malden , MA 02148 , USA , and 108 Cowley Road , Oxford OX4 1JF , UK . Blackwell Publishing 2002 Online-Ressource nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Life cycle assessment (LCA) is a framework for comparing products according to their total estimated environmental impact, summed over all chemical emissions and activities associated with a product at all stages in its life cycle (from raw material acquisition, manufacturing, use, to final disposal). For each chemical involved, the exposure associated with the mass released into the environment, integrated over time and space, is multiplied by a toxicological measure to estimate the likelihood of effects and their potential consequences. In this article, we explore the use of quantitative methods drawn from conventional single-chemical regulatory risk assessments to create a procedure for the estimation of the cancer effect measure in the impact phase of LCA. The approach is based on the maximum likelihood estimate of the effect dose inducing a 10% response over background, ED10, and default linear low-dose extrapolation using the slope βED10 (0.1/ED10). The calculated effects may correspond to residual risks below current regulatory compliance requirements that occur over multiple generations and at multiple locations; but at the very least they represent a “using up” of some portion of the human population's ability to accommodate emissions. Preliminary comparisons are performed with existing measures, such as the U.S. Environmental Protection Agency's (U.S. EPA's) slope factor measure q1*. By analyzing bioassay data for 44 chemicals drawn from the EPA's Integrated Risk Information System (IRIS) database, we explore estimating ED10 from more readily available information such as the median tumor dose rate TD50 and the median single lethal dose LD50. Based on the TD50, we then estimate the ED10 for more than 600 chemicals. Differences in potential consequences, or severity, are addressed by combining βED10 with the measure disability adjusted life years per affected person, DALYp. Most of the variation among chemicals for cancer effects is found to be due to differences in the slope factors (βED10) ranging from 10−4 up to 104 (risk of cancer/mg/kg-day). 2008 Blackwell Publishing Journal Backfiles 1879-2005 |2008|||||||||| Life cycle impact assessment (LCA) Pennington, David verfasserin aut Rhomberg, Lorenz verfasserin aut Brand, Kevin oth Jolliet, Olivier oth In Risk analysis Oxford [u.a.] : Wiley-Blackwell, 1981 22(2002), 5, Seite 0 Online-Ressource (DE-627)NLEJ243926847 (DE-600)2001458-2 1539-6924 nnns volume:22 year:2002 number:5 pages:0 http://dx.doi.org/10.1111/1539-6924.00262 text/html Verlag Deutschlandweit zugänglich Volltext GBV_USEFLAG_U ZDB-1-DJB GBV_NL_ARTICLE AR 22 2002 5 0 |
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Assessing Human Health Response in Life Cycle Assessment Using ED10s and DALYs: Part 1—Cancer Effects |
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Assessing Human Health Response in Life Cycle Assessment Using ED10s and DALYs: Part 1—Cancer Effects |
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Crettaz, Pierre |
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Crettaz, Pierre Pennington, David Rhomberg, Lorenz |
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assessing human health response in life cycle assessment using ed10s and dalys: part 1—cancer effects |
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Assessing Human Health Response in Life Cycle Assessment Using ED10s and DALYs: Part 1—Cancer Effects |
| abstract |
Life cycle assessment (LCA) is a framework for comparing products according to their total estimated environmental impact, summed over all chemical emissions and activities associated with a product at all stages in its life cycle (from raw material acquisition, manufacturing, use, to final disposal). For each chemical involved, the exposure associated with the mass released into the environment, integrated over time and space, is multiplied by a toxicological measure to estimate the likelihood of effects and their potential consequences. In this article, we explore the use of quantitative methods drawn from conventional single-chemical regulatory risk assessments to create a procedure for the estimation of the cancer effect measure in the impact phase of LCA. The approach is based on the maximum likelihood estimate of the effect dose inducing a 10% response over background, ED10, and default linear low-dose extrapolation using the slope βED10 (0.1/ED10). The calculated effects may correspond to residual risks below current regulatory compliance requirements that occur over multiple generations and at multiple locations; but at the very least they represent a “using up” of some portion of the human population's ability to accommodate emissions. Preliminary comparisons are performed with existing measures, such as the U.S. Environmental Protection Agency's (U.S. EPA's) slope factor measure q1*. By analyzing bioassay data for 44 chemicals drawn from the EPA's Integrated Risk Information System (IRIS) database, we explore estimating ED10 from more readily available information such as the median tumor dose rate TD50 and the median single lethal dose LD50. Based on the TD50, we then estimate the ED10 for more than 600 chemicals. Differences in potential consequences, or severity, are addressed by combining βED10 with the measure disability adjusted life years per affected person, DALYp. Most of the variation among chemicals for cancer effects is found to be due to differences in the slope factors (βED10) ranging from 10−4 up to 104 (risk of cancer/mg/kg-day). |
| abstractGer |
Life cycle assessment (LCA) is a framework for comparing products according to their total estimated environmental impact, summed over all chemical emissions and activities associated with a product at all stages in its life cycle (from raw material acquisition, manufacturing, use, to final disposal). For each chemical involved, the exposure associated with the mass released into the environment, integrated over time and space, is multiplied by a toxicological measure to estimate the likelihood of effects and their potential consequences. In this article, we explore the use of quantitative methods drawn from conventional single-chemical regulatory risk assessments to create a procedure for the estimation of the cancer effect measure in the impact phase of LCA. The approach is based on the maximum likelihood estimate of the effect dose inducing a 10% response over background, ED10, and default linear low-dose extrapolation using the slope βED10 (0.1/ED10). The calculated effects may correspond to residual risks below current regulatory compliance requirements that occur over multiple generations and at multiple locations; but at the very least they represent a “using up” of some portion of the human population's ability to accommodate emissions. Preliminary comparisons are performed with existing measures, such as the U.S. Environmental Protection Agency's (U.S. EPA's) slope factor measure q1*. By analyzing bioassay data for 44 chemicals drawn from the EPA's Integrated Risk Information System (IRIS) database, we explore estimating ED10 from more readily available information such as the median tumor dose rate TD50 and the median single lethal dose LD50. Based on the TD50, we then estimate the ED10 for more than 600 chemicals. Differences in potential consequences, or severity, are addressed by combining βED10 with the measure disability adjusted life years per affected person, DALYp. Most of the variation among chemicals for cancer effects is found to be due to differences in the slope factors (βED10) ranging from 10−4 up to 104 (risk of cancer/mg/kg-day). |
| abstract_unstemmed |
Life cycle assessment (LCA) is a framework for comparing products according to their total estimated environmental impact, summed over all chemical emissions and activities associated with a product at all stages in its life cycle (from raw material acquisition, manufacturing, use, to final disposal). For each chemical involved, the exposure associated with the mass released into the environment, integrated over time and space, is multiplied by a toxicological measure to estimate the likelihood of effects and their potential consequences. In this article, we explore the use of quantitative methods drawn from conventional single-chemical regulatory risk assessments to create a procedure for the estimation of the cancer effect measure in the impact phase of LCA. The approach is based on the maximum likelihood estimate of the effect dose inducing a 10% response over background, ED10, and default linear low-dose extrapolation using the slope βED10 (0.1/ED10). The calculated effects may correspond to residual risks below current regulatory compliance requirements that occur over multiple generations and at multiple locations; but at the very least they represent a “using up” of some portion of the human population's ability to accommodate emissions. Preliminary comparisons are performed with existing measures, such as the U.S. Environmental Protection Agency's (U.S. EPA's) slope factor measure q1*. By analyzing bioassay data for 44 chemicals drawn from the EPA's Integrated Risk Information System (IRIS) database, we explore estimating ED10 from more readily available information such as the median tumor dose rate TD50 and the median single lethal dose LD50. Based on the TD50, we then estimate the ED10 for more than 600 chemicals. Differences in potential consequences, or severity, are addressed by combining βED10 with the measure disability adjusted life years per affected person, DALYp. Most of the variation among chemicals for cancer effects is found to be due to differences in the slope factors (βED10) ranging from 10−4 up to 104 (risk of cancer/mg/kg-day). |
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Assessing Human Health Response in Life Cycle Assessment Using ED10s and DALYs: Part 1—Cancer Effects |
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Pennington, David Rhomberg, Lorenz Brand, Kevin Jolliet, Olivier |
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