Comparison of fast versus slow rewarming following acute moderate hypothermia in rats
Background: The aim of this study was to compare the biochemical and physiological responses of fast vs. slow rewarming from moderate hypothermia in anaesthetized rats. Methods: Anaesthetized rats were surface cooled to 28 °C, for 20 min, then rewarmed either quickly over 30 min or slowly over 120 m...
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| Autor*in: |
Eshel, Gideon - MD [verfasserIn] Reisler, Gad - MD [verfasserIn] Berkovitch, Matitiahu - MD [verfasserIn] Shapira, Shlomo - MD Grauer, Ettie - PHD Barr, Joseph - MD |
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E-Artikel |
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| Erschienen: |
Oxford UK: Blackwell Science Ltd. ; 2002 |
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| Umfang: |
Online-Ressource |
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| Reproduktion: |
2002 ; Blackwell Publishing Journal Backfiles 1879-2005 |
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| Übergeordnetes Werk: |
In: Pediatric anesthesia - Oxford [u.a.] : Wiley-Blackwell, 1991, 12(2002), 3, Seite 0 |
| Übergeordnetes Werk: |
volume:12 ; year:2002 ; number:3 ; pages:0 |
| Links: |
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| DOI / URN: |
10.1046/j.1460-9592.2002.00801.x |
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| Katalog-ID: |
NLEJ243872666 |
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| 520 | |a Background: The aim of this study was to compare the biochemical and physiological responses of fast vs. slow rewarming from moderate hypothermia in anaesthetized rats. Methods: Anaesthetized rats were surface cooled to 28 °C, for 20 min, then rewarmed either quickly over 30 min or slowly over 120 min with monitoring of vital signs, systemic vascular resistance (SVR), cardiac output, biochemical changes and activity for 31 days. Results: At hypothermia, cardiac output decreased to 77 ± 38 ml·min–1 and lactate increased to 4.62 ± 4.73 mmol·l–1. Fast rewarming caused an abrupt increase in cardiac output (270 ± 24 ml·min–1) and a sharp drop in SVR (325.6 ± 23.3 dyne·s–1·cm–5), compared with a smoother course with cardiac output (142 ± 18 ml·min–1, P < 0.01) and SVR (662.8 ± 41.0 dyne·s–1·cm–5, P < 0.01), measured during slow rewarming. Lactate failed to return to normal values (upon returning to normothermia) (2.5 ± 0.75 mmol·l–1) only in the fast rewarming group. In both groups, activity in the open field was not different from control rats. Conclusions: In rats, moderate hypothermia for 20 min does not appear to cause lasting biochemical or behavioural consequences, whether rewarming lasted over 30 or 120 min. However, there was a greater early change in cardiac output and heart rate, due to systemic vasodilatation in the fast rewarming animals. These acute changes may have consequences in patients with compromized cardiovascular reserves. | ||
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| 700 | 1 | |a Grauer, Ettie |c PHD |4 oth | |
| 700 | 1 | |a Barr, Joseph |c MD |4 oth | |
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10.1046/j.1460-9592.2002.00801.x doi (DE-627)NLEJ243872666 DE-627 ger DE-627 rakwb Eshel, Gideon MD verfasserin aut Comparison of fast versus slow rewarming following acute moderate hypothermia in rats Oxford UK Blackwell Science Ltd. 2002 Online-Ressource nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Background: The aim of this study was to compare the biochemical and physiological responses of fast vs. slow rewarming from moderate hypothermia in anaesthetized rats. Methods: Anaesthetized rats were surface cooled to 28 °C, for 20 min, then rewarmed either quickly over 30 min or slowly over 120 min with monitoring of vital signs, systemic vascular resistance (SVR), cardiac output, biochemical changes and activity for 31 days. Results: At hypothermia, cardiac output decreased to 77 ± 38 ml·min–1 and lactate increased to 4.62 ± 4.73 mmol·l–1. Fast rewarming caused an abrupt increase in cardiac output (270 ± 24 ml·min–1) and a sharp drop in SVR (325.6 ± 23.3 dyne·s–1·cm–5), compared with a smoother course with cardiac output (142 ± 18 ml·min–1, P < 0.01) and SVR (662.8 ± 41.0 dyne·s–1·cm–5, P < 0.01), measured during slow rewarming. Lactate failed to return to normal values (upon returning to normothermia) (2.5 ± 0.75 mmol·l–1) only in the fast rewarming group. In both groups, activity in the open field was not different from control rats. Conclusions: In rats, moderate hypothermia for 20 min does not appear to cause lasting biochemical or behavioural consequences, whether rewarming lasted over 30 or 120 min. However, there was a greater early change in cardiac output and heart rate, due to systemic vasodilatation in the fast rewarming animals. These acute changes may have consequences in patients with compromized cardiovascular reserves. 2002 Blackwell Publishing Journal Backfiles 1879-2005 |2002|||||||||| cardiac output Reisler, Gad MD verfasserin aut Berkovitch, Matitiahu MD verfasserin aut Shapira, Shlomo MD oth Grauer, Ettie PHD oth Barr, Joseph MD oth In Pediatric anesthesia Oxford [u.a.] : Wiley-Blackwell, 1991 12(2002), 3, Seite 0 Online-Ressource (DE-627)NLEJ243926200 (DE-600)2008564-3 1460-9592 nnns volume:12 year:2002 number:3 pages:0 http://dx.doi.org/10.1046/j.1460-9592.2002.00801.x text/html Verlag Deutschlandweit zugänglich Volltext GBV_USEFLAG_U ZDB-1-DJB GBV_NL_ARTICLE AR 12 2002 3 0 |
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10.1046/j.1460-9592.2002.00801.x doi (DE-627)NLEJ243872666 DE-627 ger DE-627 rakwb Eshel, Gideon MD verfasserin aut Comparison of fast versus slow rewarming following acute moderate hypothermia in rats Oxford UK Blackwell Science Ltd. 2002 Online-Ressource nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Background: The aim of this study was to compare the biochemical and physiological responses of fast vs. slow rewarming from moderate hypothermia in anaesthetized rats. Methods: Anaesthetized rats were surface cooled to 28 °C, for 20 min, then rewarmed either quickly over 30 min or slowly over 120 min with monitoring of vital signs, systemic vascular resistance (SVR), cardiac output, biochemical changes and activity for 31 days. Results: At hypothermia, cardiac output decreased to 77 ± 38 ml·min–1 and lactate increased to 4.62 ± 4.73 mmol·l–1. Fast rewarming caused an abrupt increase in cardiac output (270 ± 24 ml·min–1) and a sharp drop in SVR (325.6 ± 23.3 dyne·s–1·cm–5), compared with a smoother course with cardiac output (142 ± 18 ml·min–1, P < 0.01) and SVR (662.8 ± 41.0 dyne·s–1·cm–5, P < 0.01), measured during slow rewarming. Lactate failed to return to normal values (upon returning to normothermia) (2.5 ± 0.75 mmol·l–1) only in the fast rewarming group. In both groups, activity in the open field was not different from control rats. Conclusions: In rats, moderate hypothermia for 20 min does not appear to cause lasting biochemical or behavioural consequences, whether rewarming lasted over 30 or 120 min. However, there was a greater early change in cardiac output and heart rate, due to systemic vasodilatation in the fast rewarming animals. These acute changes may have consequences in patients with compromized cardiovascular reserves. 2002 Blackwell Publishing Journal Backfiles 1879-2005 |2002|||||||||| cardiac output Reisler, Gad MD verfasserin aut Berkovitch, Matitiahu MD verfasserin aut Shapira, Shlomo MD oth Grauer, Ettie PHD oth Barr, Joseph MD oth In Pediatric anesthesia Oxford [u.a.] : Wiley-Blackwell, 1991 12(2002), 3, Seite 0 Online-Ressource (DE-627)NLEJ243926200 (DE-600)2008564-3 1460-9592 nnns volume:12 year:2002 number:3 pages:0 http://dx.doi.org/10.1046/j.1460-9592.2002.00801.x text/html Verlag Deutschlandweit zugänglich Volltext GBV_USEFLAG_U ZDB-1-DJB GBV_NL_ARTICLE AR 12 2002 3 0 |
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10.1046/j.1460-9592.2002.00801.x doi (DE-627)NLEJ243872666 DE-627 ger DE-627 rakwb Eshel, Gideon MD verfasserin aut Comparison of fast versus slow rewarming following acute moderate hypothermia in rats Oxford UK Blackwell Science Ltd. 2002 Online-Ressource nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Background: The aim of this study was to compare the biochemical and physiological responses of fast vs. slow rewarming from moderate hypothermia in anaesthetized rats. Methods: Anaesthetized rats were surface cooled to 28 °C, for 20 min, then rewarmed either quickly over 30 min or slowly over 120 min with monitoring of vital signs, systemic vascular resistance (SVR), cardiac output, biochemical changes and activity for 31 days. Results: At hypothermia, cardiac output decreased to 77 ± 38 ml·min–1 and lactate increased to 4.62 ± 4.73 mmol·l–1. Fast rewarming caused an abrupt increase in cardiac output (270 ± 24 ml·min–1) and a sharp drop in SVR (325.6 ± 23.3 dyne·s–1·cm–5), compared with a smoother course with cardiac output (142 ± 18 ml·min–1, P < 0.01) and SVR (662.8 ± 41.0 dyne·s–1·cm–5, P < 0.01), measured during slow rewarming. Lactate failed to return to normal values (upon returning to normothermia) (2.5 ± 0.75 mmol·l–1) only in the fast rewarming group. In both groups, activity in the open field was not different from control rats. Conclusions: In rats, moderate hypothermia for 20 min does not appear to cause lasting biochemical or behavioural consequences, whether rewarming lasted over 30 or 120 min. However, there was a greater early change in cardiac output and heart rate, due to systemic vasodilatation in the fast rewarming animals. These acute changes may have consequences in patients with compromized cardiovascular reserves. 2002 Blackwell Publishing Journal Backfiles 1879-2005 |2002|||||||||| cardiac output Reisler, Gad MD verfasserin aut Berkovitch, Matitiahu MD verfasserin aut Shapira, Shlomo MD oth Grauer, Ettie PHD oth Barr, Joseph MD oth In Pediatric anesthesia Oxford [u.a.] : Wiley-Blackwell, 1991 12(2002), 3, Seite 0 Online-Ressource (DE-627)NLEJ243926200 (DE-600)2008564-3 1460-9592 nnns volume:12 year:2002 number:3 pages:0 http://dx.doi.org/10.1046/j.1460-9592.2002.00801.x text/html Verlag Deutschlandweit zugänglich Volltext GBV_USEFLAG_U ZDB-1-DJB GBV_NL_ARTICLE AR 12 2002 3 0 |
| allfieldsGer |
10.1046/j.1460-9592.2002.00801.x doi (DE-627)NLEJ243872666 DE-627 ger DE-627 rakwb Eshel, Gideon MD verfasserin aut Comparison of fast versus slow rewarming following acute moderate hypothermia in rats Oxford UK Blackwell Science Ltd. 2002 Online-Ressource nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Background: The aim of this study was to compare the biochemical and physiological responses of fast vs. slow rewarming from moderate hypothermia in anaesthetized rats. Methods: Anaesthetized rats were surface cooled to 28 °C, for 20 min, then rewarmed either quickly over 30 min or slowly over 120 min with monitoring of vital signs, systemic vascular resistance (SVR), cardiac output, biochemical changes and activity for 31 days. Results: At hypothermia, cardiac output decreased to 77 ± 38 ml·min–1 and lactate increased to 4.62 ± 4.73 mmol·l–1. Fast rewarming caused an abrupt increase in cardiac output (270 ± 24 ml·min–1) and a sharp drop in SVR (325.6 ± 23.3 dyne·s–1·cm–5), compared with a smoother course with cardiac output (142 ± 18 ml·min–1, P < 0.01) and SVR (662.8 ± 41.0 dyne·s–1·cm–5, P < 0.01), measured during slow rewarming. Lactate failed to return to normal values (upon returning to normothermia) (2.5 ± 0.75 mmol·l–1) only in the fast rewarming group. In both groups, activity in the open field was not different from control rats. Conclusions: In rats, moderate hypothermia for 20 min does not appear to cause lasting biochemical or behavioural consequences, whether rewarming lasted over 30 or 120 min. However, there was a greater early change in cardiac output and heart rate, due to systemic vasodilatation in the fast rewarming animals. These acute changes may have consequences in patients with compromized cardiovascular reserves. 2002 Blackwell Publishing Journal Backfiles 1879-2005 |2002|||||||||| cardiac output Reisler, Gad MD verfasserin aut Berkovitch, Matitiahu MD verfasserin aut Shapira, Shlomo MD oth Grauer, Ettie PHD oth Barr, Joseph MD oth In Pediatric anesthesia Oxford [u.a.] : Wiley-Blackwell, 1991 12(2002), 3, Seite 0 Online-Ressource (DE-627)NLEJ243926200 (DE-600)2008564-3 1460-9592 nnns volume:12 year:2002 number:3 pages:0 http://dx.doi.org/10.1046/j.1460-9592.2002.00801.x text/html Verlag Deutschlandweit zugänglich Volltext GBV_USEFLAG_U ZDB-1-DJB GBV_NL_ARTICLE AR 12 2002 3 0 |
| allfieldsSound |
10.1046/j.1460-9592.2002.00801.x doi (DE-627)NLEJ243872666 DE-627 ger DE-627 rakwb Eshel, Gideon MD verfasserin aut Comparison of fast versus slow rewarming following acute moderate hypothermia in rats Oxford UK Blackwell Science Ltd. 2002 Online-Ressource nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Background: The aim of this study was to compare the biochemical and physiological responses of fast vs. slow rewarming from moderate hypothermia in anaesthetized rats. Methods: Anaesthetized rats were surface cooled to 28 °C, for 20 min, then rewarmed either quickly over 30 min or slowly over 120 min with monitoring of vital signs, systemic vascular resistance (SVR), cardiac output, biochemical changes and activity for 31 days. Results: At hypothermia, cardiac output decreased to 77 ± 38 ml·min–1 and lactate increased to 4.62 ± 4.73 mmol·l–1. Fast rewarming caused an abrupt increase in cardiac output (270 ± 24 ml·min–1) and a sharp drop in SVR (325.6 ± 23.3 dyne·s–1·cm–5), compared with a smoother course with cardiac output (142 ± 18 ml·min–1, P < 0.01) and SVR (662.8 ± 41.0 dyne·s–1·cm–5, P < 0.01), measured during slow rewarming. Lactate failed to return to normal values (upon returning to normothermia) (2.5 ± 0.75 mmol·l–1) only in the fast rewarming group. In both groups, activity in the open field was not different from control rats. Conclusions: In rats, moderate hypothermia for 20 min does not appear to cause lasting biochemical or behavioural consequences, whether rewarming lasted over 30 or 120 min. However, there was a greater early change in cardiac output and heart rate, due to systemic vasodilatation in the fast rewarming animals. These acute changes may have consequences in patients with compromized cardiovascular reserves. 2002 Blackwell Publishing Journal Backfiles 1879-2005 |2002|||||||||| cardiac output Reisler, Gad MD verfasserin aut Berkovitch, Matitiahu MD verfasserin aut Shapira, Shlomo MD oth Grauer, Ettie PHD oth Barr, Joseph MD oth In Pediatric anesthesia Oxford [u.a.] : Wiley-Blackwell, 1991 12(2002), 3, Seite 0 Online-Ressource (DE-627)NLEJ243926200 (DE-600)2008564-3 1460-9592 nnns volume:12 year:2002 number:3 pages:0 http://dx.doi.org/10.1046/j.1460-9592.2002.00801.x text/html Verlag Deutschlandweit zugänglich Volltext GBV_USEFLAG_U ZDB-1-DJB GBV_NL_ARTICLE AR 12 2002 3 0 |
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Eshel, Gideon Reisler, Gad Berkovitch, Matitiahu |
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Eshel, Gideon |
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comparison of fast versus slow rewarming following acute moderate hypothermia in rats |
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Comparison of fast versus slow rewarming following acute moderate hypothermia in rats |
| abstract |
Background: The aim of this study was to compare the biochemical and physiological responses of fast vs. slow rewarming from moderate hypothermia in anaesthetized rats. Methods: Anaesthetized rats were surface cooled to 28 °C, for 20 min, then rewarmed either quickly over 30 min or slowly over 120 min with monitoring of vital signs, systemic vascular resistance (SVR), cardiac output, biochemical changes and activity for 31 days. Results: At hypothermia, cardiac output decreased to 77 ± 38 ml·min–1 and lactate increased to 4.62 ± 4.73 mmol·l–1. Fast rewarming caused an abrupt increase in cardiac output (270 ± 24 ml·min–1) and a sharp drop in SVR (325.6 ± 23.3 dyne·s–1·cm–5), compared with a smoother course with cardiac output (142 ± 18 ml·min–1, P < 0.01) and SVR (662.8 ± 41.0 dyne·s–1·cm–5, P < 0.01), measured during slow rewarming. Lactate failed to return to normal values (upon returning to normothermia) (2.5 ± 0.75 mmol·l–1) only in the fast rewarming group. In both groups, activity in the open field was not different from control rats. Conclusions: In rats, moderate hypothermia for 20 min does not appear to cause lasting biochemical or behavioural consequences, whether rewarming lasted over 30 or 120 min. However, there was a greater early change in cardiac output and heart rate, due to systemic vasodilatation in the fast rewarming animals. These acute changes may have consequences in patients with compromized cardiovascular reserves. |
| abstractGer |
Background: The aim of this study was to compare the biochemical and physiological responses of fast vs. slow rewarming from moderate hypothermia in anaesthetized rats. Methods: Anaesthetized rats were surface cooled to 28 °C, for 20 min, then rewarmed either quickly over 30 min or slowly over 120 min with monitoring of vital signs, systemic vascular resistance (SVR), cardiac output, biochemical changes and activity for 31 days. Results: At hypothermia, cardiac output decreased to 77 ± 38 ml·min–1 and lactate increased to 4.62 ± 4.73 mmol·l–1. Fast rewarming caused an abrupt increase in cardiac output (270 ± 24 ml·min–1) and a sharp drop in SVR (325.6 ± 23.3 dyne·s–1·cm–5), compared with a smoother course with cardiac output (142 ± 18 ml·min–1, P < 0.01) and SVR (662.8 ± 41.0 dyne·s–1·cm–5, P < 0.01), measured during slow rewarming. Lactate failed to return to normal values (upon returning to normothermia) (2.5 ± 0.75 mmol·l–1) only in the fast rewarming group. In both groups, activity in the open field was not different from control rats. Conclusions: In rats, moderate hypothermia for 20 min does not appear to cause lasting biochemical or behavioural consequences, whether rewarming lasted over 30 or 120 min. However, there was a greater early change in cardiac output and heart rate, due to systemic vasodilatation in the fast rewarming animals. These acute changes may have consequences in patients with compromized cardiovascular reserves. |
| abstract_unstemmed |
Background: The aim of this study was to compare the biochemical and physiological responses of fast vs. slow rewarming from moderate hypothermia in anaesthetized rats. Methods: Anaesthetized rats were surface cooled to 28 °C, for 20 min, then rewarmed either quickly over 30 min or slowly over 120 min with monitoring of vital signs, systemic vascular resistance (SVR), cardiac output, biochemical changes and activity for 31 days. Results: At hypothermia, cardiac output decreased to 77 ± 38 ml·min–1 and lactate increased to 4.62 ± 4.73 mmol·l–1. Fast rewarming caused an abrupt increase in cardiac output (270 ± 24 ml·min–1) and a sharp drop in SVR (325.6 ± 23.3 dyne·s–1·cm–5), compared with a smoother course with cardiac output (142 ± 18 ml·min–1, P < 0.01) and SVR (662.8 ± 41.0 dyne·s–1·cm–5, P < 0.01), measured during slow rewarming. Lactate failed to return to normal values (upon returning to normothermia) (2.5 ± 0.75 mmol·l–1) only in the fast rewarming group. In both groups, activity in the open field was not different from control rats. Conclusions: In rats, moderate hypothermia for 20 min does not appear to cause lasting biochemical or behavioural consequences, whether rewarming lasted over 30 or 120 min. However, there was a greater early change in cardiac output and heart rate, due to systemic vasodilatation in the fast rewarming animals. These acute changes may have consequences in patients with compromized cardiovascular reserves. |
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Comparison of fast versus slow rewarming following acute moderate hypothermia in rats |
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Reisler, Gad MD Berkovitch, Matitiahu MD Shapira, Shlomo MD Grauer, Ettie PHD Barr, Joseph MD |
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