Prenatal exposure to house dust mite allergen (Der p 1), cord blood T cell phenotype and cytokine production and atopic dermatitis during the first year of life
This study investigated the influence of prenatal exposure to house dust mite (HDM, D. pteronyssinus) on interleukin (IL)-2, interferon-gamma (IFN-γ) and IL-4 producing CD4+ and CD8+ T lymphocytes in cord blood as well as on the development of sensitization and occurrence of atopic dermatitis (AD) a...
Ausführliche Beschreibung
Gespeichert in:
| Autor*in: |
Hagendorens, Margo M. [verfasserIn] Ebo, Didier G. [verfasserIn] Bridts, Chris H. [verfasserIn] |
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| Format: |
E-Artikel |
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| Erschienen: |
Oxford, UK: Munksgaard International Publishers ; 2004 |
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| Schlagwörter: |
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| Umfang: |
Online-Ressource |
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| Reproduktion: |
2004 ; Blackwell Publishing Journal Backfiles 1879-2005 |
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| Übergeordnetes Werk: |
In: Pediatric allergy and immunology - Oxford [u.a.] : Wiley-Blackwell, 1990, 15(2004), 4, Seite 0 |
| Übergeordnetes Werk: |
volume:15 ; year:2004 ; number:4 ; pages:0 |
| Links: |
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| DOI / URN: |
10.1111/j.1399-3038.2004.00169.x |
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| Katalog-ID: |
NLEJ243879431 |
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| 100 | 1 | |a Hagendorens, Margo M. |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a Prenatal exposure to house dust mite allergen (Der p 1), cord blood T cell phenotype and cytokine production and atopic dermatitis during the first year of life |
| 264 | 1 | |a Oxford, UK |b Munksgaard International Publishers |c 2004 | |
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| 520 | |a This study investigated the influence of prenatal exposure to house dust mite (HDM, D. pteronyssinus) on interleukin (IL)-2, interferon-gamma (IFN-γ) and IL-4 producing CD4+ and CD8+ T lymphocytes in cord blood as well as on the development of sensitization and occurrence of atopic dermatitis (AD) as the first symptom of allergy during the first year of life. Dust samples (n = 22) were collected by vacuum cleaning the maternal mattress during early to mid-pregnancy. In these samples, the amount of the major HDM antigen (Der p 1) was assessed by a sensitive enzyme-linked immunosorbent assay technique (detection limit 0.004 μg/g dust). Flow cytometry was used to determine cord blood lymphocyte subtypes and to quantify the intracellular amounts of IL-2, IFN-γ and IL-4 produced by cord blood CD4+ helper and CD8+ cytotoxic T lymphocytes, both spontaneously and after stimulation with phorbol-12-mirystate-13-acetate and ionomycin. Children were followed for 1 yr for the presence of symptoms associated with allergy. In addition, at the age of 1 yr specific IgE to different classical inhalant and food allergens was measured. Higher prenatal exposure to Der p 1 (>0.2 μg/g dust) was associated with a significant lower percentage of IFN-γ producing stimulated CD4+ T lymphocytes, compared with lower prenatal Der p 1 exposure (p = 0.03). The presence of AD during the first year of life (n = 9) was associated with an increased number of naive CD4+ CD45RA+ lymphocytes (p = 0.03), with an increased spontaneous IL-4 production by CD8+ lymphocytes (p = 0.04) and with a decreased percentage of IFN-γ producing stimulated CD4+ lymphocytes (p = 0.04). Furthermore, exposure to HDM during pregnancy tended to be higher in mothers of children with AD during the first year of life when compared with those without AD (p = 0.08). This study shows that the level of prenatal exposure to Der p 1 influences the immune profile of cord blood T lymphocytes and the clinical outcome in early life. Therefore, the prenatal environment must be regarded as a possible early risk factors for allergic diseases in children. | ||
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| 700 | 1 | |a Ebo, Didier G. |e verfasserin |4 aut | |
| 700 | 1 | |a Bridts, Chris H. |e verfasserin |4 aut | |
| 700 | 1 | |a Water, Leen Van de |4 oth | |
| 700 | 1 | |a De Clerck, Luc S. |4 oth | |
| 700 | 1 | |a Stevens, Wim J. |4 oth | |
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10.1111/j.1399-3038.2004.00169.x doi (DE-627)NLEJ243879431 DE-627 ger DE-627 rakwb Hagendorens, Margo M. verfasserin aut Prenatal exposure to house dust mite allergen (Der p 1), cord blood T cell phenotype and cytokine production and atopic dermatitis during the first year of life Oxford, UK Munksgaard International Publishers 2004 Online-Ressource nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier This study investigated the influence of prenatal exposure to house dust mite (HDM, D. pteronyssinus) on interleukin (IL)-2, interferon-gamma (IFN-γ) and IL-4 producing CD4+ and CD8+ T lymphocytes in cord blood as well as on the development of sensitization and occurrence of atopic dermatitis (AD) as the first symptom of allergy during the first year of life. Dust samples (n = 22) were collected by vacuum cleaning the maternal mattress during early to mid-pregnancy. In these samples, the amount of the major HDM antigen (Der p 1) was assessed by a sensitive enzyme-linked immunosorbent assay technique (detection limit 0.004 μg/g dust). Flow cytometry was used to determine cord blood lymphocyte subtypes and to quantify the intracellular amounts of IL-2, IFN-γ and IL-4 produced by cord blood CD4+ helper and CD8+ cytotoxic T lymphocytes, both spontaneously and after stimulation with phorbol-12-mirystate-13-acetate and ionomycin. Children were followed for 1 yr for the presence of symptoms associated with allergy. In addition, at the age of 1 yr specific IgE to different classical inhalant and food allergens was measured. Higher prenatal exposure to Der p 1 (>0.2 μg/g dust) was associated with a significant lower percentage of IFN-γ producing stimulated CD4+ T lymphocytes, compared with lower prenatal Der p 1 exposure (p = 0.03). The presence of AD during the first year of life (n = 9) was associated with an increased number of naive CD4+ CD45RA+ lymphocytes (p = 0.03), with an increased spontaneous IL-4 production by CD8+ lymphocytes (p = 0.04) and with a decreased percentage of IFN-γ producing stimulated CD4+ lymphocytes (p = 0.04). Furthermore, exposure to HDM during pregnancy tended to be higher in mothers of children with AD during the first year of life when compared with those without AD (p = 0.08). This study shows that the level of prenatal exposure to Der p 1 influences the immune profile of cord blood T lymphocytes and the clinical outcome in early life. Therefore, the prenatal environment must be regarded as a possible early risk factors for allergic diseases in children. 2004 Blackwell Publishing Journal Backfiles 1879-2005 |2004|||||||||| house dust mite Ebo, Didier G. verfasserin aut Bridts, Chris H. verfasserin aut Water, Leen Van de oth De Clerck, Luc S. oth Stevens, Wim J. oth In Pediatric allergy and immunology Oxford [u.a.] : Wiley-Blackwell, 1990 15(2004), 4, Seite 0 Online-Ressource (DE-627)NLEJ243926308 (DE-600)2008584-9 1399-3038 nnns volume:15 year:2004 number:4 pages:0 http://dx.doi.org/10.1111/j.1399-3038.2004.00169.x text/html Verlag Deutschlandweit zugänglich Volltext GBV_USEFLAG_U ZDB-1-DJB GBV_NL_ARTICLE AR 15 2004 4 0 |
| spelling |
10.1111/j.1399-3038.2004.00169.x doi (DE-627)NLEJ243879431 DE-627 ger DE-627 rakwb Hagendorens, Margo M. verfasserin aut Prenatal exposure to house dust mite allergen (Der p 1), cord blood T cell phenotype and cytokine production and atopic dermatitis during the first year of life Oxford, UK Munksgaard International Publishers 2004 Online-Ressource nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier This study investigated the influence of prenatal exposure to house dust mite (HDM, D. pteronyssinus) on interleukin (IL)-2, interferon-gamma (IFN-γ) and IL-4 producing CD4+ and CD8+ T lymphocytes in cord blood as well as on the development of sensitization and occurrence of atopic dermatitis (AD) as the first symptom of allergy during the first year of life. Dust samples (n = 22) were collected by vacuum cleaning the maternal mattress during early to mid-pregnancy. In these samples, the amount of the major HDM antigen (Der p 1) was assessed by a sensitive enzyme-linked immunosorbent assay technique (detection limit 0.004 μg/g dust). Flow cytometry was used to determine cord blood lymphocyte subtypes and to quantify the intracellular amounts of IL-2, IFN-γ and IL-4 produced by cord blood CD4+ helper and CD8+ cytotoxic T lymphocytes, both spontaneously and after stimulation with phorbol-12-mirystate-13-acetate and ionomycin. Children were followed for 1 yr for the presence of symptoms associated with allergy. In addition, at the age of 1 yr specific IgE to different classical inhalant and food allergens was measured. Higher prenatal exposure to Der p 1 (>0.2 μg/g dust) was associated with a significant lower percentage of IFN-γ producing stimulated CD4+ T lymphocytes, compared with lower prenatal Der p 1 exposure (p = 0.03). The presence of AD during the first year of life (n = 9) was associated with an increased number of naive CD4+ CD45RA+ lymphocytes (p = 0.03), with an increased spontaneous IL-4 production by CD8+ lymphocytes (p = 0.04) and with a decreased percentage of IFN-γ producing stimulated CD4+ lymphocytes (p = 0.04). Furthermore, exposure to HDM during pregnancy tended to be higher in mothers of children with AD during the first year of life when compared with those without AD (p = 0.08). This study shows that the level of prenatal exposure to Der p 1 influences the immune profile of cord blood T lymphocytes and the clinical outcome in early life. Therefore, the prenatal environment must be regarded as a possible early risk factors for allergic diseases in children. 2004 Blackwell Publishing Journal Backfiles 1879-2005 |2004|||||||||| house dust mite Ebo, Didier G. verfasserin aut Bridts, Chris H. verfasserin aut Water, Leen Van de oth De Clerck, Luc S. oth Stevens, Wim J. oth In Pediatric allergy and immunology Oxford [u.a.] : Wiley-Blackwell, 1990 15(2004), 4, Seite 0 Online-Ressource (DE-627)NLEJ243926308 (DE-600)2008584-9 1399-3038 nnns volume:15 year:2004 number:4 pages:0 http://dx.doi.org/10.1111/j.1399-3038.2004.00169.x text/html Verlag Deutschlandweit zugänglich Volltext GBV_USEFLAG_U ZDB-1-DJB GBV_NL_ARTICLE AR 15 2004 4 0 |
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10.1111/j.1399-3038.2004.00169.x doi (DE-627)NLEJ243879431 DE-627 ger DE-627 rakwb Hagendorens, Margo M. verfasserin aut Prenatal exposure to house dust mite allergen (Der p 1), cord blood T cell phenotype and cytokine production and atopic dermatitis during the first year of life Oxford, UK Munksgaard International Publishers 2004 Online-Ressource nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier This study investigated the influence of prenatal exposure to house dust mite (HDM, D. pteronyssinus) on interleukin (IL)-2, interferon-gamma (IFN-γ) and IL-4 producing CD4+ and CD8+ T lymphocytes in cord blood as well as on the development of sensitization and occurrence of atopic dermatitis (AD) as the first symptom of allergy during the first year of life. Dust samples (n = 22) were collected by vacuum cleaning the maternal mattress during early to mid-pregnancy. In these samples, the amount of the major HDM antigen (Der p 1) was assessed by a sensitive enzyme-linked immunosorbent assay technique (detection limit 0.004 μg/g dust). Flow cytometry was used to determine cord blood lymphocyte subtypes and to quantify the intracellular amounts of IL-2, IFN-γ and IL-4 produced by cord blood CD4+ helper and CD8+ cytotoxic T lymphocytes, both spontaneously and after stimulation with phorbol-12-mirystate-13-acetate and ionomycin. Children were followed for 1 yr for the presence of symptoms associated with allergy. In addition, at the age of 1 yr specific IgE to different classical inhalant and food allergens was measured. Higher prenatal exposure to Der p 1 (>0.2 μg/g dust) was associated with a significant lower percentage of IFN-γ producing stimulated CD4+ T lymphocytes, compared with lower prenatal Der p 1 exposure (p = 0.03). The presence of AD during the first year of life (n = 9) was associated with an increased number of naive CD4+ CD45RA+ lymphocytes (p = 0.03), with an increased spontaneous IL-4 production by CD8+ lymphocytes (p = 0.04) and with a decreased percentage of IFN-γ producing stimulated CD4+ lymphocytes (p = 0.04). Furthermore, exposure to HDM during pregnancy tended to be higher in mothers of children with AD during the first year of life when compared with those without AD (p = 0.08). This study shows that the level of prenatal exposure to Der p 1 influences the immune profile of cord blood T lymphocytes and the clinical outcome in early life. Therefore, the prenatal environment must be regarded as a possible early risk factors for allergic diseases in children. 2004 Blackwell Publishing Journal Backfiles 1879-2005 |2004|||||||||| house dust mite Ebo, Didier G. verfasserin aut Bridts, Chris H. verfasserin aut Water, Leen Van de oth De Clerck, Luc S. oth Stevens, Wim J. oth In Pediatric allergy and immunology Oxford [u.a.] : Wiley-Blackwell, 1990 15(2004), 4, Seite 0 Online-Ressource (DE-627)NLEJ243926308 (DE-600)2008584-9 1399-3038 nnns volume:15 year:2004 number:4 pages:0 http://dx.doi.org/10.1111/j.1399-3038.2004.00169.x text/html Verlag Deutschlandweit zugänglich Volltext GBV_USEFLAG_U ZDB-1-DJB GBV_NL_ARTICLE AR 15 2004 4 0 |
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10.1111/j.1399-3038.2004.00169.x doi (DE-627)NLEJ243879431 DE-627 ger DE-627 rakwb Hagendorens, Margo M. verfasserin aut Prenatal exposure to house dust mite allergen (Der p 1), cord blood T cell phenotype and cytokine production and atopic dermatitis during the first year of life Oxford, UK Munksgaard International Publishers 2004 Online-Ressource nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier This study investigated the influence of prenatal exposure to house dust mite (HDM, D. pteronyssinus) on interleukin (IL)-2, interferon-gamma (IFN-γ) and IL-4 producing CD4+ and CD8+ T lymphocytes in cord blood as well as on the development of sensitization and occurrence of atopic dermatitis (AD) as the first symptom of allergy during the first year of life. Dust samples (n = 22) were collected by vacuum cleaning the maternal mattress during early to mid-pregnancy. In these samples, the amount of the major HDM antigen (Der p 1) was assessed by a sensitive enzyme-linked immunosorbent assay technique (detection limit 0.004 μg/g dust). Flow cytometry was used to determine cord blood lymphocyte subtypes and to quantify the intracellular amounts of IL-2, IFN-γ and IL-4 produced by cord blood CD4+ helper and CD8+ cytotoxic T lymphocytes, both spontaneously and after stimulation with phorbol-12-mirystate-13-acetate and ionomycin. Children were followed for 1 yr for the presence of symptoms associated with allergy. In addition, at the age of 1 yr specific IgE to different classical inhalant and food allergens was measured. Higher prenatal exposure to Der p 1 (>0.2 μg/g dust) was associated with a significant lower percentage of IFN-γ producing stimulated CD4+ T lymphocytes, compared with lower prenatal Der p 1 exposure (p = 0.03). The presence of AD during the first year of life (n = 9) was associated with an increased number of naive CD4+ CD45RA+ lymphocytes (p = 0.03), with an increased spontaneous IL-4 production by CD8+ lymphocytes (p = 0.04) and with a decreased percentage of IFN-γ producing stimulated CD4+ lymphocytes (p = 0.04). Furthermore, exposure to HDM during pregnancy tended to be higher in mothers of children with AD during the first year of life when compared with those without AD (p = 0.08). This study shows that the level of prenatal exposure to Der p 1 influences the immune profile of cord blood T lymphocytes and the clinical outcome in early life. Therefore, the prenatal environment must be regarded as a possible early risk factors for allergic diseases in children. 2004 Blackwell Publishing Journal Backfiles 1879-2005 |2004|||||||||| house dust mite Ebo, Didier G. verfasserin aut Bridts, Chris H. verfasserin aut Water, Leen Van de oth De Clerck, Luc S. oth Stevens, Wim J. oth In Pediatric allergy and immunology Oxford [u.a.] : Wiley-Blackwell, 1990 15(2004), 4, Seite 0 Online-Ressource (DE-627)NLEJ243926308 (DE-600)2008584-9 1399-3038 nnns volume:15 year:2004 number:4 pages:0 http://dx.doi.org/10.1111/j.1399-3038.2004.00169.x text/html Verlag Deutschlandweit zugänglich Volltext GBV_USEFLAG_U ZDB-1-DJB GBV_NL_ARTICLE AR 15 2004 4 0 |
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10.1111/j.1399-3038.2004.00169.x doi (DE-627)NLEJ243879431 DE-627 ger DE-627 rakwb Hagendorens, Margo M. verfasserin aut Prenatal exposure to house dust mite allergen (Der p 1), cord blood T cell phenotype and cytokine production and atopic dermatitis during the first year of life Oxford, UK Munksgaard International Publishers 2004 Online-Ressource nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier This study investigated the influence of prenatal exposure to house dust mite (HDM, D. pteronyssinus) on interleukin (IL)-2, interferon-gamma (IFN-γ) and IL-4 producing CD4+ and CD8+ T lymphocytes in cord blood as well as on the development of sensitization and occurrence of atopic dermatitis (AD) as the first symptom of allergy during the first year of life. Dust samples (n = 22) were collected by vacuum cleaning the maternal mattress during early to mid-pregnancy. In these samples, the amount of the major HDM antigen (Der p 1) was assessed by a sensitive enzyme-linked immunosorbent assay technique (detection limit 0.004 μg/g dust). Flow cytometry was used to determine cord blood lymphocyte subtypes and to quantify the intracellular amounts of IL-2, IFN-γ and IL-4 produced by cord blood CD4+ helper and CD8+ cytotoxic T lymphocytes, both spontaneously and after stimulation with phorbol-12-mirystate-13-acetate and ionomycin. Children were followed for 1 yr for the presence of symptoms associated with allergy. In addition, at the age of 1 yr specific IgE to different classical inhalant and food allergens was measured. Higher prenatal exposure to Der p 1 (>0.2 μg/g dust) was associated with a significant lower percentage of IFN-γ producing stimulated CD4+ T lymphocytes, compared with lower prenatal Der p 1 exposure (p = 0.03). The presence of AD during the first year of life (n = 9) was associated with an increased number of naive CD4+ CD45RA+ lymphocytes (p = 0.03), with an increased spontaneous IL-4 production by CD8+ lymphocytes (p = 0.04) and with a decreased percentage of IFN-γ producing stimulated CD4+ lymphocytes (p = 0.04). Furthermore, exposure to HDM during pregnancy tended to be higher in mothers of children with AD during the first year of life when compared with those without AD (p = 0.08). This study shows that the level of prenatal exposure to Der p 1 influences the immune profile of cord blood T lymphocytes and the clinical outcome in early life. Therefore, the prenatal environment must be regarded as a possible early risk factors for allergic diseases in children. 2004 Blackwell Publishing Journal Backfiles 1879-2005 |2004|||||||||| house dust mite Ebo, Didier G. verfasserin aut Bridts, Chris H. verfasserin aut Water, Leen Van de oth De Clerck, Luc S. oth Stevens, Wim J. oth In Pediatric allergy and immunology Oxford [u.a.] : Wiley-Blackwell, 1990 15(2004), 4, Seite 0 Online-Ressource (DE-627)NLEJ243926308 (DE-600)2008584-9 1399-3038 nnns volume:15 year:2004 number:4 pages:0 http://dx.doi.org/10.1111/j.1399-3038.2004.00169.x text/html Verlag Deutschlandweit zugänglich Volltext GBV_USEFLAG_U ZDB-1-DJB GBV_NL_ARTICLE AR 15 2004 4 0 |
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<?xml version="1.0" encoding="UTF-8"?><collection xmlns="http://www.loc.gov/MARC21/slim"><record><leader>01000caa a22002652 4500</leader><controlfield tag="001">NLEJ243879431</controlfield><controlfield tag="003">DE-627</controlfield><controlfield tag="005">20230505223941.0</controlfield><controlfield tag="007">cr uuu---uuuuu</controlfield><controlfield tag="008">120427s2004 xx |||||o 00| ||und c</controlfield><datafield tag="024" ind1="7" ind2=" "><subfield code="a">10.1111/j.1399-3038.2004.00169.x</subfield><subfield code="2">doi</subfield></datafield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(DE-627)NLEJ243879431</subfield></datafield><datafield tag="040" ind1=" " ind2=" "><subfield code="a">DE-627</subfield><subfield code="b">ger</subfield><subfield code="c">DE-627</subfield><subfield code="e">rakwb</subfield></datafield><datafield tag="100" ind1="1" ind2=" "><subfield code="a">Hagendorens, Margo M.</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="245" ind1="1" ind2="0"><subfield code="a">Prenatal exposure to house dust mite allergen (Der p 1), cord blood T cell phenotype and cytokine production and atopic dermatitis during the first year of life</subfield></datafield><datafield tag="264" ind1=" " ind2="1"><subfield code="a">Oxford, UK</subfield><subfield code="b">Munksgaard International Publishers</subfield><subfield code="c">2004</subfield></datafield><datafield tag="300" ind1=" " ind2=" "><subfield code="a">Online-Ressource</subfield></datafield><datafield tag="336" ind1=" " ind2=" "><subfield code="a">nicht spezifiziert</subfield><subfield code="b">zzz</subfield><subfield code="2">rdacontent</subfield></datafield><datafield tag="337" ind1=" " ind2=" "><subfield code="a">nicht spezifiziert</subfield><subfield code="b">z</subfield><subfield code="2">rdamedia</subfield></datafield><datafield tag="338" ind1=" " ind2=" "><subfield code="a">nicht spezifiziert</subfield><subfield code="b">zu</subfield><subfield code="2">rdacarrier</subfield></datafield><datafield tag="520" ind1=" " ind2=" "><subfield code="a">This study investigated the influence of prenatal exposure to house dust mite (HDM, D. pteronyssinus) on interleukin (IL)-2, interferon-gamma (IFN-γ) and IL-4 producing CD4+ and CD8+ T lymphocytes in cord blood as well as on the development of sensitization and occurrence of atopic dermatitis (AD) as the first symptom of allergy during the first year of life. Dust samples (n = 22) were collected by vacuum cleaning the maternal mattress during early to mid-pregnancy. In these samples, the amount of the major HDM antigen (Der p 1) was assessed by a sensitive enzyme-linked immunosorbent assay technique (detection limit 0.004 μg/g dust). Flow cytometry was used to determine cord blood lymphocyte subtypes and to quantify the intracellular amounts of IL-2, IFN-γ and IL-4 produced by cord blood CD4+ helper and CD8+ cytotoxic T lymphocytes, both spontaneously and after stimulation with phorbol-12-mirystate-13-acetate and ionomycin. Children were followed for 1 yr for the presence of symptoms associated with allergy. In addition, at the age of 1 yr specific IgE to different classical inhalant and food allergens was measured. Higher prenatal exposure to Der p 1 (>0.2 μg/g dust) was associated with a significant lower percentage of IFN-γ producing stimulated CD4+ T lymphocytes, compared with lower prenatal Der p 1 exposure (p = 0.03). The presence of AD during the first year of life (n = 9) was associated with an increased number of naive CD4+ CD45RA+ lymphocytes (p = 0.03), with an increased spontaneous IL-4 production by CD8+ lymphocytes (p = 0.04) and with a decreased percentage of IFN-γ producing stimulated CD4+ lymphocytes (p = 0.04). Furthermore, exposure to HDM during pregnancy tended to be higher in mothers of children with AD during the first year of life when compared with those without AD (p = 0.08). This study shows that the level of prenatal exposure to Der p 1 influences the immune profile of cord blood T lymphocytes and the clinical outcome in early life. 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Blackwell Publishing Journal Backfiles 1879-2005 |
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Hagendorens, Margo M. |
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Hagendorens, Margo M. misc house dust mite Prenatal exposure to house dust mite allergen (Der p 1), cord blood T cell phenotype and cytokine production and atopic dermatitis during the first year of life |
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Prenatal exposure to house dust mite allergen (Der p 1), cord blood T cell phenotype and cytokine production and atopic dermatitis during the first year of life house dust mite |
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prenatal exposure to house dust mite allergen (der p 1), cord blood t cell phenotype and cytokine production and atopic dermatitis during the first year of life |
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Prenatal exposure to house dust mite allergen (Der p 1), cord blood T cell phenotype and cytokine production and atopic dermatitis during the first year of life |
| abstract |
This study investigated the influence of prenatal exposure to house dust mite (HDM, D. pteronyssinus) on interleukin (IL)-2, interferon-gamma (IFN-γ) and IL-4 producing CD4+ and CD8+ T lymphocytes in cord blood as well as on the development of sensitization and occurrence of atopic dermatitis (AD) as the first symptom of allergy during the first year of life. Dust samples (n = 22) were collected by vacuum cleaning the maternal mattress during early to mid-pregnancy. In these samples, the amount of the major HDM antigen (Der p 1) was assessed by a sensitive enzyme-linked immunosorbent assay technique (detection limit 0.004 μg/g dust). Flow cytometry was used to determine cord blood lymphocyte subtypes and to quantify the intracellular amounts of IL-2, IFN-γ and IL-4 produced by cord blood CD4+ helper and CD8+ cytotoxic T lymphocytes, both spontaneously and after stimulation with phorbol-12-mirystate-13-acetate and ionomycin. Children were followed for 1 yr for the presence of symptoms associated with allergy. In addition, at the age of 1 yr specific IgE to different classical inhalant and food allergens was measured. Higher prenatal exposure to Der p 1 (>0.2 μg/g dust) was associated with a significant lower percentage of IFN-γ producing stimulated CD4+ T lymphocytes, compared with lower prenatal Der p 1 exposure (p = 0.03). The presence of AD during the first year of life (n = 9) was associated with an increased number of naive CD4+ CD45RA+ lymphocytes (p = 0.03), with an increased spontaneous IL-4 production by CD8+ lymphocytes (p = 0.04) and with a decreased percentage of IFN-γ producing stimulated CD4+ lymphocytes (p = 0.04). Furthermore, exposure to HDM during pregnancy tended to be higher in mothers of children with AD during the first year of life when compared with those without AD (p = 0.08). This study shows that the level of prenatal exposure to Der p 1 influences the immune profile of cord blood T lymphocytes and the clinical outcome in early life. Therefore, the prenatal environment must be regarded as a possible early risk factors for allergic diseases in children. |
| abstractGer |
This study investigated the influence of prenatal exposure to house dust mite (HDM, D. pteronyssinus) on interleukin (IL)-2, interferon-gamma (IFN-γ) and IL-4 producing CD4+ and CD8+ T lymphocytes in cord blood as well as on the development of sensitization and occurrence of atopic dermatitis (AD) as the first symptom of allergy during the first year of life. Dust samples (n = 22) were collected by vacuum cleaning the maternal mattress during early to mid-pregnancy. In these samples, the amount of the major HDM antigen (Der p 1) was assessed by a sensitive enzyme-linked immunosorbent assay technique (detection limit 0.004 μg/g dust). Flow cytometry was used to determine cord blood lymphocyte subtypes and to quantify the intracellular amounts of IL-2, IFN-γ and IL-4 produced by cord blood CD4+ helper and CD8+ cytotoxic T lymphocytes, both spontaneously and after stimulation with phorbol-12-mirystate-13-acetate and ionomycin. Children were followed for 1 yr for the presence of symptoms associated with allergy. In addition, at the age of 1 yr specific IgE to different classical inhalant and food allergens was measured. Higher prenatal exposure to Der p 1 (>0.2 μg/g dust) was associated with a significant lower percentage of IFN-γ producing stimulated CD4+ T lymphocytes, compared with lower prenatal Der p 1 exposure (p = 0.03). The presence of AD during the first year of life (n = 9) was associated with an increased number of naive CD4+ CD45RA+ lymphocytes (p = 0.03), with an increased spontaneous IL-4 production by CD8+ lymphocytes (p = 0.04) and with a decreased percentage of IFN-γ producing stimulated CD4+ lymphocytes (p = 0.04). Furthermore, exposure to HDM during pregnancy tended to be higher in mothers of children with AD during the first year of life when compared with those without AD (p = 0.08). This study shows that the level of prenatal exposure to Der p 1 influences the immune profile of cord blood T lymphocytes and the clinical outcome in early life. Therefore, the prenatal environment must be regarded as a possible early risk factors for allergic diseases in children. |
| abstract_unstemmed |
This study investigated the influence of prenatal exposure to house dust mite (HDM, D. pteronyssinus) on interleukin (IL)-2, interferon-gamma (IFN-γ) and IL-4 producing CD4+ and CD8+ T lymphocytes in cord blood as well as on the development of sensitization and occurrence of atopic dermatitis (AD) as the first symptom of allergy during the first year of life. Dust samples (n = 22) were collected by vacuum cleaning the maternal mattress during early to mid-pregnancy. In these samples, the amount of the major HDM antigen (Der p 1) was assessed by a sensitive enzyme-linked immunosorbent assay technique (detection limit 0.004 μg/g dust). Flow cytometry was used to determine cord blood lymphocyte subtypes and to quantify the intracellular amounts of IL-2, IFN-γ and IL-4 produced by cord blood CD4+ helper and CD8+ cytotoxic T lymphocytes, both spontaneously and after stimulation with phorbol-12-mirystate-13-acetate and ionomycin. Children were followed for 1 yr for the presence of symptoms associated with allergy. In addition, at the age of 1 yr specific IgE to different classical inhalant and food allergens was measured. Higher prenatal exposure to Der p 1 (>0.2 μg/g dust) was associated with a significant lower percentage of IFN-γ producing stimulated CD4+ T lymphocytes, compared with lower prenatal Der p 1 exposure (p = 0.03). The presence of AD during the first year of life (n = 9) was associated with an increased number of naive CD4+ CD45RA+ lymphocytes (p = 0.03), with an increased spontaneous IL-4 production by CD8+ lymphocytes (p = 0.04) and with a decreased percentage of IFN-γ producing stimulated CD4+ lymphocytes (p = 0.04). Furthermore, exposure to HDM during pregnancy tended to be higher in mothers of children with AD during the first year of life when compared with those without AD (p = 0.08). This study shows that the level of prenatal exposure to Der p 1 influences the immune profile of cord blood T lymphocytes and the clinical outcome in early life. Therefore, the prenatal environment must be regarded as a possible early risk factors for allergic diseases in children. |
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