The Role of Heat Shock Proteins and Their Receptors in the Activation of the Immune System
Heat shock proteins (HSPs) have been described aspotent tumor vaccines in animal models and are currentlystudied in clinical trials. The underlying immuneresponse relies on immunogenic peptides that theHSPs have acquired intracellularly by interfering withthe classical antigen processing pathways. T...
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Walter de Gruyter ; 2005 |
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Copyright © 2001 by Walter de Gruyter GmbH & Co. KG |
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Walter de Gruyter Online Zeitschriften |
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In: 382(2005), 4 vom: 01. Juni, Seite 629-636 volume:382 ; year:2005 ; number:4 ; day:01 ; month:06 ; pages:629-636 ; extent:8 |
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| DOI / URN: |
10.1515/BC.2001.074 |
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| 520 | |a Heat shock proteins (HSPs) have been described aspotent tumor vaccines in animal models and are currentlystudied in clinical trials. The underlying immuneresponse relies on immunogenic peptides that theHSPs have acquired intracellularly by interfering withthe classical antigen processing pathways. Therehave been numerous reports shedding light on howHSPs are able to gain this function and a number ofimportant requirements for HSPmediated specificimmunity have been described: first, the ability ofHSPs to bind immunogenic peptides. Second, the acquisitionof HSPs by specialized antigen presentingcells with efficient antigen processing pathways capableof inducing cellular immune responses. Third,the existence of specific receptors on the surfaces ofantigen presenting cells, allowing efficient and rapiduptake of HSPpeptide complexes from the extracellularfluid. And fourth, the ability of heat shock proteinsto activate antigen presenting cells, enablingthe latter to prime cytotoxic T cell responses againstthe peptides associated to HSPs. | ||
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10.1515/BC.2001.074 doi artikel_Grundlieferung.pp (DE-627)NLEJ246511877 DE-627 ger DE-627 rakwb The Role of Heat Shock Proteins and Their Receptors in the Activation of the Immune System Walter de Gruyter 2005 8 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Copyright © 2001 by Walter de Gruyter GmbH & Co. KG Heat shock proteins (HSPs) have been described aspotent tumor vaccines in animal models and are currentlystudied in clinical trials. The underlying immuneresponse relies on immunogenic peptides that theHSPs have acquired intracellularly by interfering withthe classical antigen processing pathways. Therehave been numerous reports shedding light on howHSPs are able to gain this function and a number ofimportant requirements for HSPmediated specificimmunity have been described: first, the ability ofHSPs to bind immunogenic peptides. Second, the acquisitionof HSPs by specialized antigen presentingcells with efficient antigen processing pathways capableof inducing cellular immune responses. Third,the existence of specific receptors on the surfaces ofantigen presenting cells, allowing efficient and rapiduptake of HSPpeptide complexes from the extracellularfluid. And fourth, the ability of heat shock proteinsto activate antigen presenting cells, enablingthe latter to prime cytotoxic T cell responses againstthe peptides associated to HSPs. Walter de Gruyter Online Zeitschriften Singh-Jasuja, Harpreet oth Hilf, Norbert oth Arnold-Schild, Danièle oth Schild, Hansjörg oth In 382(2005), 4 vom: 01. Juni, Seite 629-636 volume:382 year:2005 number:4 day:01 month:06 pages:629-636 extent:8 https://doi.org/10.1515/BC.2001.074 Deutschlandweit zugänglich GBV_USEFLAG_U ZDB-1-DGR GBV_NL_ARTICLE AR 382 2005 4 01 06 629-636 8 |
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10.1515/BC.2001.074 doi artikel_Grundlieferung.pp (DE-627)NLEJ246511877 DE-627 ger DE-627 rakwb The Role of Heat Shock Proteins and Their Receptors in the Activation of the Immune System Walter de Gruyter 2005 8 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Copyright © 2001 by Walter de Gruyter GmbH & Co. KG Heat shock proteins (HSPs) have been described aspotent tumor vaccines in animal models and are currentlystudied in clinical trials. The underlying immuneresponse relies on immunogenic peptides that theHSPs have acquired intracellularly by interfering withthe classical antigen processing pathways. Therehave been numerous reports shedding light on howHSPs are able to gain this function and a number ofimportant requirements for HSPmediated specificimmunity have been described: first, the ability ofHSPs to bind immunogenic peptides. Second, the acquisitionof HSPs by specialized antigen presentingcells with efficient antigen processing pathways capableof inducing cellular immune responses. Third,the existence of specific receptors on the surfaces ofantigen presenting cells, allowing efficient and rapiduptake of HSPpeptide complexes from the extracellularfluid. And fourth, the ability of heat shock proteinsto activate antigen presenting cells, enablingthe latter to prime cytotoxic T cell responses againstthe peptides associated to HSPs. Walter de Gruyter Online Zeitschriften Singh-Jasuja, Harpreet oth Hilf, Norbert oth Arnold-Schild, Danièle oth Schild, Hansjörg oth In 382(2005), 4 vom: 01. Juni, Seite 629-636 volume:382 year:2005 number:4 day:01 month:06 pages:629-636 extent:8 https://doi.org/10.1515/BC.2001.074 Deutschlandweit zugänglich GBV_USEFLAG_U ZDB-1-DGR GBV_NL_ARTICLE AR 382 2005 4 01 06 629-636 8 |
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10.1515/BC.2001.074 doi artikel_Grundlieferung.pp (DE-627)NLEJ246511877 DE-627 ger DE-627 rakwb The Role of Heat Shock Proteins and Their Receptors in the Activation of the Immune System Walter de Gruyter 2005 8 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Copyright © 2001 by Walter de Gruyter GmbH & Co. KG Heat shock proteins (HSPs) have been described aspotent tumor vaccines in animal models and are currentlystudied in clinical trials. The underlying immuneresponse relies on immunogenic peptides that theHSPs have acquired intracellularly by interfering withthe classical antigen processing pathways. Therehave been numerous reports shedding light on howHSPs are able to gain this function and a number ofimportant requirements for HSPmediated specificimmunity have been described: first, the ability ofHSPs to bind immunogenic peptides. Second, the acquisitionof HSPs by specialized antigen presentingcells with efficient antigen processing pathways capableof inducing cellular immune responses. Third,the existence of specific receptors on the surfaces ofantigen presenting cells, allowing efficient and rapiduptake of HSPpeptide complexes from the extracellularfluid. And fourth, the ability of heat shock proteinsto activate antigen presenting cells, enablingthe latter to prime cytotoxic T cell responses againstthe peptides associated to HSPs. Walter de Gruyter Online Zeitschriften Singh-Jasuja, Harpreet oth Hilf, Norbert oth Arnold-Schild, Danièle oth Schild, Hansjörg oth In 382(2005), 4 vom: 01. Juni, Seite 629-636 volume:382 year:2005 number:4 day:01 month:06 pages:629-636 extent:8 https://doi.org/10.1515/BC.2001.074 Deutschlandweit zugänglich GBV_USEFLAG_U ZDB-1-DGR GBV_NL_ARTICLE AR 382 2005 4 01 06 629-636 8 |
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10.1515/BC.2001.074 doi artikel_Grundlieferung.pp (DE-627)NLEJ246511877 DE-627 ger DE-627 rakwb The Role of Heat Shock Proteins and Their Receptors in the Activation of the Immune System Walter de Gruyter 2005 8 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Copyright © 2001 by Walter de Gruyter GmbH & Co. KG Heat shock proteins (HSPs) have been described aspotent tumor vaccines in animal models and are currentlystudied in clinical trials. The underlying immuneresponse relies on immunogenic peptides that theHSPs have acquired intracellularly by interfering withthe classical antigen processing pathways. Therehave been numerous reports shedding light on howHSPs are able to gain this function and a number ofimportant requirements for HSPmediated specificimmunity have been described: first, the ability ofHSPs to bind immunogenic peptides. Second, the acquisitionof HSPs by specialized antigen presentingcells with efficient antigen processing pathways capableof inducing cellular immune responses. Third,the existence of specific receptors on the surfaces ofantigen presenting cells, allowing efficient and rapiduptake of HSPpeptide complexes from the extracellularfluid. And fourth, the ability of heat shock proteinsto activate antigen presenting cells, enablingthe latter to prime cytotoxic T cell responses againstthe peptides associated to HSPs. Walter de Gruyter Online Zeitschriften Singh-Jasuja, Harpreet oth Hilf, Norbert oth Arnold-Schild, Danièle oth Schild, Hansjörg oth In 382(2005), 4 vom: 01. Juni, Seite 629-636 volume:382 year:2005 number:4 day:01 month:06 pages:629-636 extent:8 https://doi.org/10.1515/BC.2001.074 Deutschlandweit zugänglich GBV_USEFLAG_U ZDB-1-DGR GBV_NL_ARTICLE AR 382 2005 4 01 06 629-636 8 |
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the role of heat shock proteins and their receptors in the activation of the immune system |
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The Role of Heat Shock Proteins and Their Receptors in the Activation of the Immune System |
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Heat shock proteins (HSPs) have been described aspotent tumor vaccines in animal models and are currentlystudied in clinical trials. The underlying immuneresponse relies on immunogenic peptides that theHSPs have acquired intracellularly by interfering withthe classical antigen processing pathways. Therehave been numerous reports shedding light on howHSPs are able to gain this function and a number ofimportant requirements for HSPmediated specificimmunity have been described: first, the ability ofHSPs to bind immunogenic peptides. Second, the acquisitionof HSPs by specialized antigen presentingcells with efficient antigen processing pathways capableof inducing cellular immune responses. Third,the existence of specific receptors on the surfaces ofantigen presenting cells, allowing efficient and rapiduptake of HSPpeptide complexes from the extracellularfluid. And fourth, the ability of heat shock proteinsto activate antigen presenting cells, enablingthe latter to prime cytotoxic T cell responses againstthe peptides associated to HSPs. Copyright © 2001 by Walter de Gruyter GmbH & Co. KG |
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Heat shock proteins (HSPs) have been described aspotent tumor vaccines in animal models and are currentlystudied in clinical trials. The underlying immuneresponse relies on immunogenic peptides that theHSPs have acquired intracellularly by interfering withthe classical antigen processing pathways. Therehave been numerous reports shedding light on howHSPs are able to gain this function and a number ofimportant requirements for HSPmediated specificimmunity have been described: first, the ability ofHSPs to bind immunogenic peptides. Second, the acquisitionof HSPs by specialized antigen presentingcells with efficient antigen processing pathways capableof inducing cellular immune responses. Third,the existence of specific receptors on the surfaces ofantigen presenting cells, allowing efficient and rapiduptake of HSPpeptide complexes from the extracellularfluid. And fourth, the ability of heat shock proteinsto activate antigen presenting cells, enablingthe latter to prime cytotoxic T cell responses againstthe peptides associated to HSPs. Copyright © 2001 by Walter de Gruyter GmbH & Co. KG |
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Heat shock proteins (HSPs) have been described aspotent tumor vaccines in animal models and are currentlystudied in clinical trials. The underlying immuneresponse relies on immunogenic peptides that theHSPs have acquired intracellularly by interfering withthe classical antigen processing pathways. Therehave been numerous reports shedding light on howHSPs are able to gain this function and a number ofimportant requirements for HSPmediated specificimmunity have been described: first, the ability ofHSPs to bind immunogenic peptides. Second, the acquisitionof HSPs by specialized antigen presentingcells with efficient antigen processing pathways capableof inducing cellular immune responses. Third,the existence of specific receptors on the surfaces ofantigen presenting cells, allowing efficient and rapiduptake of HSPpeptide complexes from the extracellularfluid. And fourth, the ability of heat shock proteinsto activate antigen presenting cells, enablingthe latter to prime cytotoxic T cell responses againstthe peptides associated to HSPs. Copyright © 2001 by Walter de Gruyter GmbH & Co. KG |
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KG</subfield></datafield><datafield tag="520" ind1=" " ind2=" "><subfield code="a">Heat shock proteins (HSPs) have been described aspotent tumor vaccines in animal models and are currentlystudied in clinical trials. The underlying immuneresponse relies on immunogenic peptides that theHSPs have acquired intracellularly by interfering withthe classical antigen processing pathways. Therehave been numerous reports shedding light on howHSPs are able to gain this function and a number ofimportant requirements for HSPmediated specificimmunity have been described: first, the ability ofHSPs to bind immunogenic peptides. Second, the acquisitionof HSPs by specialized antigen presentingcells with efficient antigen processing pathways capableof inducing cellular immune responses. Third,the existence of specific receptors on the surfaces ofantigen presenting cells, allowing efficient and rapiduptake of HSPpeptide complexes from the extracellularfluid. And fourth, the ability of heat shock proteinsto activate antigen presenting cells, enablingthe latter to prime cytotoxic T cell responses againstthe peptides associated to HSPs.</subfield></datafield><datafield tag="533" ind1=" " ind2=" "><subfield code="f">Walter de Gruyter Online Zeitschriften</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Singh-Jasuja, Harpreet</subfield><subfield code="4">oth</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Hilf, Norbert</subfield><subfield code="4">oth</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Arnold-Schild, Danièle</subfield><subfield code="4">oth</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Schild, Hansjörg</subfield><subfield code="4">oth</subfield></datafield><datafield tag="773" ind1="0" ind2="8"><subfield code="i">In</subfield><subfield code="g">382(2005), 4 vom: 01. Juni, Seite 629-636</subfield></datafield><datafield tag="773" ind1="1" ind2="8"><subfield code="g">volume:382</subfield><subfield code="g">year:2005</subfield><subfield code="g">number:4</subfield><subfield code="g">day:01</subfield><subfield code="g">month:06</subfield><subfield code="g">pages:629-636</subfield><subfield code="g">extent:8</subfield></datafield><datafield tag="856" ind1="4" ind2="0"><subfield code="u">https://doi.org/10.1515/BC.2001.074</subfield><subfield code="z">Deutschlandweit zugänglich</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_USEFLAG_U</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">ZDB-1-DGR</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_NL_ARTICLE</subfield></datafield><datafield tag="951" ind1=" " ind2=" "><subfield code="a">AR</subfield></datafield><datafield tag="952" ind1=" " ind2=" "><subfield code="d">382</subfield><subfield code="j">2005</subfield><subfield code="e">4</subfield><subfield code="b">01</subfield><subfield code="c">06</subfield><subfield code="h">629-636</subfield><subfield code="g">8</subfield></datafield></record></collection>
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