Modulation of the Endosomal and Lysosomal Distribution of Cathepsins B, L and S in Human Monocytes/Macrophages
Endosomal and lysosomal fractions of human monocytes/macrophages prepared from buffy coats wereanalyzed for activities of cathepsins B, L and S, andexpression of cathepsin proteins along with majorhistocompatibility complex class I and class II moleculesunder control and immunomodulatory conditions....
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E-Artikel |
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Walter de Gruyter ; 2005 |
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Copyright © 2002 by Walter de Gruyter GmbH & Co. KG |
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7 |
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Walter de Gruyter Online Zeitschriften |
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In: 383(2005), 7-8 vom: 01. Juni, Seite 1277-1283 volume:383 ; year:2005 ; number:7-8 ; day:01 ; month:06 ; pages:1277-1283 ; extent:7 |
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10.1515/BC.2002.143 |
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| 520 | |a Endosomal and lysosomal fractions of human monocytes/macrophages prepared from buffy coats wereanalyzed for activities of cathepsins B, L and S, andexpression of cathepsin proteins along with majorhistocompatibility complex class I and class II moleculesunder control and immunomodulatory conditions.While the total activity of cathepsins B, L, and Stogether remained unchanged in lysates of controlcells during culture for 72 h, the subcellular distributionof cathepsin activities underwent a shift from apredominantly endosomal localization in freshly isolatedcells to a lysosomal pattern after 72 h of culture.Interferonγ treatment for 72 h resulted in an upregulationof both major histocompatibility complex proteinsand cathepsins with differential changes incathepsin B, L and S activities in endosomes versuslysosomes. These changes suggest a remodeling ofthe endocytic machinery and imply different functionsof cathepsins B, L and S during monocyte differentiation. | ||
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10.1515/BC.2002.143 doi artikel_Grundlieferung.pp (DE-627)NLEJ246514647 DE-627 ger DE-627 rakwb Modulation of the Endosomal and Lysosomal Distribution of Cathepsins B, L and S in Human Monocytes/Macrophages Walter de Gruyter 2005 7 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Copyright © 2002 by Walter de Gruyter GmbH & Co. KG Endosomal and lysosomal fractions of human monocytes/macrophages prepared from buffy coats wereanalyzed for activities of cathepsins B, L and S, andexpression of cathepsin proteins along with majorhistocompatibility complex class I and class II moleculesunder control and immunomodulatory conditions.While the total activity of cathepsins B, L, and Stogether remained unchanged in lysates of controlcells during culture for 72 h, the subcellular distributionof cathepsin activities underwent a shift from apredominantly endosomal localization in freshly isolatedcells to a lysosomal pattern after 72 h of culture.Interferonγ treatment for 72 h resulted in an upregulationof both major histocompatibility complex proteinsand cathepsins with differential changes incathepsin B, L and S activities in endosomes versuslysosomes. These changes suggest a remodeling ofthe endocytic machinery and imply different functionsof cathepsins B, L and S during monocyte differentiation. Walter de Gruyter Online Zeitschriften Schmid, H. oth Sauerbrei, R. oth Schwarz, G. oth Weber, E. oth Kalbacher, H. oth Driessen, C. oth In 383(2005), 7-8 vom: 01. Juni, Seite 1277-1283 volume:383 year:2005 number:7-8 day:01 month:06 pages:1277-1283 extent:7 https://doi.org/10.1515/BC.2002.143 Deutschlandweit zugänglich GBV_USEFLAG_U ZDB-1-DGR GBV_NL_ARTICLE AR 383 2005 7-8 01 06 1277-1283 7 |
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10.1515/BC.2002.143 doi artikel_Grundlieferung.pp (DE-627)NLEJ246514647 DE-627 ger DE-627 rakwb Modulation of the Endosomal and Lysosomal Distribution of Cathepsins B, L and S in Human Monocytes/Macrophages Walter de Gruyter 2005 7 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Copyright © 2002 by Walter de Gruyter GmbH & Co. KG Endosomal and lysosomal fractions of human monocytes/macrophages prepared from buffy coats wereanalyzed for activities of cathepsins B, L and S, andexpression of cathepsin proteins along with majorhistocompatibility complex class I and class II moleculesunder control and immunomodulatory conditions.While the total activity of cathepsins B, L, and Stogether remained unchanged in lysates of controlcells during culture for 72 h, the subcellular distributionof cathepsin activities underwent a shift from apredominantly endosomal localization in freshly isolatedcells to a lysosomal pattern after 72 h of culture.Interferonγ treatment for 72 h resulted in an upregulationof both major histocompatibility complex proteinsand cathepsins with differential changes incathepsin B, L and S activities in endosomes versuslysosomes. These changes suggest a remodeling ofthe endocytic machinery and imply different functionsof cathepsins B, L and S during monocyte differentiation. Walter de Gruyter Online Zeitschriften Schmid, H. oth Sauerbrei, R. oth Schwarz, G. oth Weber, E. oth Kalbacher, H. oth Driessen, C. oth In 383(2005), 7-8 vom: 01. Juni, Seite 1277-1283 volume:383 year:2005 number:7-8 day:01 month:06 pages:1277-1283 extent:7 https://doi.org/10.1515/BC.2002.143 Deutschlandweit zugänglich GBV_USEFLAG_U ZDB-1-DGR GBV_NL_ARTICLE AR 383 2005 7-8 01 06 1277-1283 7 |
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10.1515/BC.2002.143 doi artikel_Grundlieferung.pp (DE-627)NLEJ246514647 DE-627 ger DE-627 rakwb Modulation of the Endosomal and Lysosomal Distribution of Cathepsins B, L and S in Human Monocytes/Macrophages Walter de Gruyter 2005 7 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Copyright © 2002 by Walter de Gruyter GmbH & Co. KG Endosomal and lysosomal fractions of human monocytes/macrophages prepared from buffy coats wereanalyzed for activities of cathepsins B, L and S, andexpression of cathepsin proteins along with majorhistocompatibility complex class I and class II moleculesunder control and immunomodulatory conditions.While the total activity of cathepsins B, L, and Stogether remained unchanged in lysates of controlcells during culture for 72 h, the subcellular distributionof cathepsin activities underwent a shift from apredominantly endosomal localization in freshly isolatedcells to a lysosomal pattern after 72 h of culture.Interferonγ treatment for 72 h resulted in an upregulationof both major histocompatibility complex proteinsand cathepsins with differential changes incathepsin B, L and S activities in endosomes versuslysosomes. These changes suggest a remodeling ofthe endocytic machinery and imply different functionsof cathepsins B, L and S during monocyte differentiation. Walter de Gruyter Online Zeitschriften Schmid, H. oth Sauerbrei, R. oth Schwarz, G. oth Weber, E. oth Kalbacher, H. oth Driessen, C. oth In 383(2005), 7-8 vom: 01. Juni, Seite 1277-1283 volume:383 year:2005 number:7-8 day:01 month:06 pages:1277-1283 extent:7 https://doi.org/10.1515/BC.2002.143 Deutschlandweit zugänglich GBV_USEFLAG_U ZDB-1-DGR GBV_NL_ARTICLE AR 383 2005 7-8 01 06 1277-1283 7 |
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10.1515/BC.2002.143 doi artikel_Grundlieferung.pp (DE-627)NLEJ246514647 DE-627 ger DE-627 rakwb Modulation of the Endosomal and Lysosomal Distribution of Cathepsins B, L and S in Human Monocytes/Macrophages Walter de Gruyter 2005 7 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Copyright © 2002 by Walter de Gruyter GmbH & Co. KG Endosomal and lysosomal fractions of human monocytes/macrophages prepared from buffy coats wereanalyzed for activities of cathepsins B, L and S, andexpression of cathepsin proteins along with majorhistocompatibility complex class I and class II moleculesunder control and immunomodulatory conditions.While the total activity of cathepsins B, L, and Stogether remained unchanged in lysates of controlcells during culture for 72 h, the subcellular distributionof cathepsin activities underwent a shift from apredominantly endosomal localization in freshly isolatedcells to a lysosomal pattern after 72 h of culture.Interferonγ treatment for 72 h resulted in an upregulationof both major histocompatibility complex proteinsand cathepsins with differential changes incathepsin B, L and S activities in endosomes versuslysosomes. These changes suggest a remodeling ofthe endocytic machinery and imply different functionsof cathepsins B, L and S during monocyte differentiation. Walter de Gruyter Online Zeitschriften Schmid, H. oth Sauerbrei, R. oth Schwarz, G. oth Weber, E. oth Kalbacher, H. oth Driessen, C. oth In 383(2005), 7-8 vom: 01. Juni, Seite 1277-1283 volume:383 year:2005 number:7-8 day:01 month:06 pages:1277-1283 extent:7 https://doi.org/10.1515/BC.2002.143 Deutschlandweit zugänglich GBV_USEFLAG_U ZDB-1-DGR GBV_NL_ARTICLE AR 383 2005 7-8 01 06 1277-1283 7 |
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10.1515/BC.2002.143 doi artikel_Grundlieferung.pp (DE-627)NLEJ246514647 DE-627 ger DE-627 rakwb Modulation of the Endosomal and Lysosomal Distribution of Cathepsins B, L and S in Human Monocytes/Macrophages Walter de Gruyter 2005 7 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Copyright © 2002 by Walter de Gruyter GmbH & Co. KG Endosomal and lysosomal fractions of human monocytes/macrophages prepared from buffy coats wereanalyzed for activities of cathepsins B, L and S, andexpression of cathepsin proteins along with majorhistocompatibility complex class I and class II moleculesunder control and immunomodulatory conditions.While the total activity of cathepsins B, L, and Stogether remained unchanged in lysates of controlcells during culture for 72 h, the subcellular distributionof cathepsin activities underwent a shift from apredominantly endosomal localization in freshly isolatedcells to a lysosomal pattern after 72 h of culture.Interferonγ treatment for 72 h resulted in an upregulationof both major histocompatibility complex proteinsand cathepsins with differential changes incathepsin B, L and S activities in endosomes versuslysosomes. These changes suggest a remodeling ofthe endocytic machinery and imply different functionsof cathepsins B, L and S during monocyte differentiation. Walter de Gruyter Online Zeitschriften Schmid, H. oth Sauerbrei, R. oth Schwarz, G. oth Weber, E. oth Kalbacher, H. oth Driessen, C. oth In 383(2005), 7-8 vom: 01. Juni, Seite 1277-1283 volume:383 year:2005 number:7-8 day:01 month:06 pages:1277-1283 extent:7 https://doi.org/10.1515/BC.2002.143 Deutschlandweit zugänglich GBV_USEFLAG_U ZDB-1-DGR GBV_NL_ARTICLE AR 383 2005 7-8 01 06 1277-1283 7 |
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Modulation of the Endosomal and Lysosomal Distribution of Cathepsins B, L and S in Human Monocytes/Macrophages |
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Endosomal and lysosomal fractions of human monocytes/macrophages prepared from buffy coats wereanalyzed for activities of cathepsins B, L and S, andexpression of cathepsin proteins along with majorhistocompatibility complex class I and class II moleculesunder control and immunomodulatory conditions.While the total activity of cathepsins B, L, and Stogether remained unchanged in lysates of controlcells during culture for 72 h, the subcellular distributionof cathepsin activities underwent a shift from apredominantly endosomal localization in freshly isolatedcells to a lysosomal pattern after 72 h of culture.Interferonγ treatment for 72 h resulted in an upregulationof both major histocompatibility complex proteinsand cathepsins with differential changes incathepsin B, L and S activities in endosomes versuslysosomes. These changes suggest a remodeling ofthe endocytic machinery and imply different functionsof cathepsins B, L and S during monocyte differentiation. Copyright © 2002 by Walter de Gruyter GmbH & Co. KG |
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Endosomal and lysosomal fractions of human monocytes/macrophages prepared from buffy coats wereanalyzed for activities of cathepsins B, L and S, andexpression of cathepsin proteins along with majorhistocompatibility complex class I and class II moleculesunder control and immunomodulatory conditions.While the total activity of cathepsins B, L, and Stogether remained unchanged in lysates of controlcells during culture for 72 h, the subcellular distributionof cathepsin activities underwent a shift from apredominantly endosomal localization in freshly isolatedcells to a lysosomal pattern after 72 h of culture.Interferonγ treatment for 72 h resulted in an upregulationof both major histocompatibility complex proteinsand cathepsins with differential changes incathepsin B, L and S activities in endosomes versuslysosomes. These changes suggest a remodeling ofthe endocytic machinery and imply different functionsof cathepsins B, L and S during monocyte differentiation. Copyright © 2002 by Walter de Gruyter GmbH & Co. KG |
| abstract_unstemmed |
Endosomal and lysosomal fractions of human monocytes/macrophages prepared from buffy coats wereanalyzed for activities of cathepsins B, L and S, andexpression of cathepsin proteins along with majorhistocompatibility complex class I and class II moleculesunder control and immunomodulatory conditions.While the total activity of cathepsins B, L, and Stogether remained unchanged in lysates of controlcells during culture for 72 h, the subcellular distributionof cathepsin activities underwent a shift from apredominantly endosomal localization in freshly isolatedcells to a lysosomal pattern after 72 h of culture.Interferonγ treatment for 72 h resulted in an upregulationof both major histocompatibility complex proteinsand cathepsins with differential changes incathepsin B, L and S activities in endosomes versuslysosomes. These changes suggest a remodeling ofthe endocytic machinery and imply different functionsof cathepsins B, L and S during monocyte differentiation. Copyright © 2002 by Walter de Gruyter GmbH & Co. KG |
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KG</subfield></datafield><datafield tag="520" ind1=" " ind2=" "><subfield code="a">Endosomal and lysosomal fractions of human monocytes/macrophages prepared from buffy coats wereanalyzed for activities of cathepsins B, L and S, andexpression of cathepsin proteins along with majorhistocompatibility complex class I and class II moleculesunder control and immunomodulatory conditions.While the total activity of cathepsins B, L, and Stogether remained unchanged in lysates of controlcells during culture for 72 h, the subcellular distributionof cathepsin activities underwent a shift from apredominantly endosomal localization in freshly isolatedcells to a lysosomal pattern after 72 h of culture.Interferonγ treatment for 72 h resulted in an upregulationof both major histocompatibility complex proteinsand cathepsins with differential changes incathepsin B, L and S activities in endosomes versuslysosomes. These changes suggest a remodeling ofthe endocytic machinery and imply different functionsof cathepsins B, L and S during monocyte differentiation.</subfield></datafield><datafield tag="533" ind1=" " ind2=" "><subfield code="f">Walter de Gruyter Online Zeitschriften</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Schmid, H.</subfield><subfield code="4">oth</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Sauerbrei, R.</subfield><subfield code="4">oth</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Schwarz, G.</subfield><subfield code="4">oth</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Weber, E.</subfield><subfield code="4">oth</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Kalbacher, H.</subfield><subfield code="4">oth</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Driessen, C.</subfield><subfield code="4">oth</subfield></datafield><datafield tag="773" ind1="0" ind2="8"><subfield code="i">In</subfield><subfield code="g">383(2005), 7-8 vom: 01. Juni, Seite 1277-1283</subfield></datafield><datafield tag="773" ind1="1" ind2="8"><subfield code="g">volume:383</subfield><subfield code="g">year:2005</subfield><subfield code="g">number:7-8</subfield><subfield code="g">day:01</subfield><subfield code="g">month:06</subfield><subfield code="g">pages:1277-1283</subfield><subfield code="g">extent:7</subfield></datafield><datafield tag="856" ind1="4" ind2="0"><subfield code="u">https://doi.org/10.1515/BC.2002.143</subfield><subfield code="z">Deutschlandweit zugänglich</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_USEFLAG_U</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">ZDB-1-DGR</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_NL_ARTICLE</subfield></datafield><datafield tag="951" ind1=" " ind2=" "><subfield code="a">AR</subfield></datafield><datafield tag="952" ind1=" " ind2=" "><subfield code="d">383</subfield><subfield code="j">2005</subfield><subfield code="e">7-8</subfield><subfield code="b">01</subfield><subfield code="c">06</subfield><subfield code="h">1277-1283</subfield><subfield code="g">7</subfield></datafield></record></collection>
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