RIM proteins and their role in synapse function
Active zones are specialized areas of the plasma membrane in the presynaptic nerve terminal that mediate neurotransmitter release and synaptic plasticity. The multidomain proteins RIM1 and RIM2 are integral components of the cytomatrix at the active zone, interacting with most other active zone-enri...
Ausführliche Beschreibung
Gespeichert in:
| Autor*in: |
Mittelstaedt, Tobias [verfasserIn] Alvaréz-Baron, Elena [verfasserIn] Schoch, Susanne [verfasserIn] |
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| Format: |
E-Artikel |
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| Erschienen: |
Walter de Gruyter ; 2010 |
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| Schlagwörter: |
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| Anmerkung: |
©2010 by Walter de Gruyter Berlin New York |
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| Umfang: |
8 |
| Reproduktion: |
Walter de Gruyter Online Zeitschriften |
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| Übergeordnetes Werk: |
Enthalten in: Biological chemistry - Berlin [u.a.] : de Gruyter, 1996, 391(2010), 6 vom: 06. Apr., Seite 599-606 |
| Übergeordnetes Werk: |
volume:391 ; year:2010 ; number:6 ; day:06 ; month:04 ; pages:599-606 ; extent:8 |
| Links: |
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| DOI / URN: |
10.1515/bc.2010.064 |
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NLEJ246527978 |
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| 520 | |a Active zones are specialized areas of the plasma membrane in the presynaptic nerve terminal that mediate neurotransmitter release and synaptic plasticity. The multidomain proteins RIM1 and RIM2 are integral components of the cytomatrix at the active zone, interacting with most other active zone-enriched proteins as well as synaptic vesicle proteins. In the brain, RIMs are present in multiple isoforms (α, β, γ) diverging in their structural composition, which mediate overlapping and distinct functions. Here, we summarize recent findings about the specific roles of the various RIM isoforms in basic synaptic vesicle release as well as long- and short-term presynaptic plasticity. | ||
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10.1515/bc.2010.064 doi artikel_Grundlieferung.pp (DE-627)NLEJ246527978 DE-627 ger DE-627 rakwb Mittelstaedt, Tobias verfasserin aut RIM proteins and their role in synapse function Walter de Gruyter 2010 8 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier ©2010 by Walter de Gruyter Berlin New York Active zones are specialized areas of the plasma membrane in the presynaptic nerve terminal that mediate neurotransmitter release and synaptic plasticity. The multidomain proteins RIM1 and RIM2 are integral components of the cytomatrix at the active zone, interacting with most other active zone-enriched proteins as well as synaptic vesicle proteins. In the brain, RIMs are present in multiple isoforms (α, β, γ) diverging in their structural composition, which mediate overlapping and distinct functions. Here, we summarize recent findings about the specific roles of the various RIM isoforms in basic synaptic vesicle release as well as long- and short-term presynaptic plasticity. Walter de Gruyter Online Zeitschriften active zone long-term potentiation (LTP) plasticity presynaptic priming synaptic vesicle Alvaréz-Baron, Elena verfasserin aut Schoch, Susanne verfasserin aut Enthalten in Biological chemistry Berlin [u.a.] : de Gruyter, 1996 391(2010), 6 vom: 06. Apr., Seite 599-606 (DE-627)NLEJ248235095 (DE-600)1466062-3 1437-4315 nnns volume:391 year:2010 number:6 day:06 month:04 pages:599-606 extent:8 https://doi.org/10.1515/bc.2010.064 Deutschlandweit zugänglich GBV_USEFLAG_U ZDB-1-DGR GBV_NL_ARTICLE AR 391 2010 6 06 04 599-606 8 |
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Active zones are specialized areas of the plasma membrane in the presynaptic nerve terminal that mediate neurotransmitter release and synaptic plasticity. The multidomain proteins RIM1 and RIM2 are integral components of the cytomatrix at the active zone, interacting with most other active zone-enriched proteins as well as synaptic vesicle proteins. In the brain, RIMs are present in multiple isoforms (α, β, γ) diverging in their structural composition, which mediate overlapping and distinct functions. Here, we summarize recent findings about the specific roles of the various RIM isoforms in basic synaptic vesicle release as well as long- and short-term presynaptic plasticity. ©2010 by Walter de Gruyter Berlin New York |
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Active zones are specialized areas of the plasma membrane in the presynaptic nerve terminal that mediate neurotransmitter release and synaptic plasticity. The multidomain proteins RIM1 and RIM2 are integral components of the cytomatrix at the active zone, interacting with most other active zone-enriched proteins as well as synaptic vesicle proteins. In the brain, RIMs are present in multiple isoforms (α, β, γ) diverging in their structural composition, which mediate overlapping and distinct functions. Here, we summarize recent findings about the specific roles of the various RIM isoforms in basic synaptic vesicle release as well as long- and short-term presynaptic plasticity. ©2010 by Walter de Gruyter Berlin New York |
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Active zones are specialized areas of the plasma membrane in the presynaptic nerve terminal that mediate neurotransmitter release and synaptic plasticity. The multidomain proteins RIM1 and RIM2 are integral components of the cytomatrix at the active zone, interacting with most other active zone-enriched proteins as well as synaptic vesicle proteins. In the brain, RIMs are present in multiple isoforms (α, β, γ) diverging in their structural composition, which mediate overlapping and distinct functions. Here, we summarize recent findings about the specific roles of the various RIM isoforms in basic synaptic vesicle release as well as long- and short-term presynaptic plasticity. ©2010 by Walter de Gruyter Berlin New York |
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The multidomain proteins RIM1 and RIM2 are integral components of the cytomatrix at the active zone, interacting with most other active zone-enriched proteins as well as synaptic vesicle proteins. In the brain, RIMs are present in multiple isoforms (α, β, γ) diverging in their structural composition, which mediate overlapping and distinct functions. 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