Secreted bone morphogenetic protein antagonists of the Chordin family
Chordin, Chordin-like 1, and Chordin-like 2 are secreted bone morphogenetic protein (BMP) antagonists with highly conserved Chordin-like cysteine-rich domains. Recently, Brorin and Brorin-like have been identified as new Chordin-like BMP antagonists. A Chordin ortholog, Short gastrulation, has been...
Ausführliche Beschreibung
Autor*in: |
Itoh, Nobuyuki [verfasserIn] Ohta, Hiroya [verfasserIn] |
---|
Format: |
E-Artikel |
---|
Erschienen: |
Walter de Gruyter ; 2010 |
---|
Schlagwörter: |
---|
Anmerkung: |
©2010 by Walter de Gruyter Berlin New York |
---|---|
Umfang: |
8 |
Reproduktion: |
Walter de Gruyter Online Zeitschriften |
---|---|
Übergeordnetes Werk: |
Enthalten in: Biomolecular concepts - Berlin : de Gruyter, 2010, 1(2010), 3-4 vom: 30. Sept., Seite 297-304 |
Übergeordnetes Werk: |
volume:1 ; year:2010 ; number:3-4 ; day:30 ; month:09 ; pages:297-304 ; extent:8 |
Links: |
---|
DOI / URN: |
10.1515/bmc.2010.026 |
---|
Katalog-ID: |
NLEJ246606991 |
---|
LEADER | 01000caa a22002652 4500 | ||
---|---|---|---|
001 | NLEJ246606991 | ||
003 | DE-627 | ||
005 | 20230505195025.0 | ||
007 | cr uuu---uuuuu | ||
008 | 220814s2010 xx |||||o 00| ||und c | ||
024 | 7 | |a 10.1515/bmc.2010.026 |2 doi | |
028 | 5 | 2 | |a artikel_Grundlieferung.pp |
035 | |a (DE-627)NLEJ246606991 | ||
040 | |a DE-627 |b ger |c DE-627 |e rakwb | ||
100 | 1 | |a Itoh, Nobuyuki |e verfasserin |4 aut | |
245 | 1 | 0 | |a Secreted bone morphogenetic protein antagonists of the Chordin family |
264 | 1 | |b Walter de Gruyter |c 2010 | |
300 | |a 8 | ||
336 | |a Text |b txt |2 rdacontent | ||
337 | |a Computermedien |b c |2 rdamedia | ||
338 | |a Online-Ressource |b cr |2 rdacarrier | ||
500 | |a ©2010 by Walter de Gruyter Berlin New York | ||
520 | |a Chordin, Chordin-like 1, and Chordin-like 2 are secreted bone morphogenetic protein (BMP) antagonists with highly conserved Chordin-like cysteine-rich domains. Recently, Brorin and Brorin-like have been identified as new Chordin-like BMP antagonists. A Chordin ortholog, Short gastrulation, has been identified in Drosophila, a protostome, but not other orthologs. By contrast, Chordin, Chordin-like 1, and Chordin-like 2 have been identified in Ciona intestinalis, the closest living relatives of the vertebrates, but Brorin and Brorin-like have not. However, all these genes have been identified in most vertebrates. These results indicate that Chordin, Chordin-like 1, and Chordin-like 2 were generated early in the metazoan lineage. Later on, Brorin and Brorin-like were potentially generated by a genome duplication event in early vertebrate evolution. All four cysteine-rich domains of Chordin are essential for the regulation of its action. However, Chordin-like 1, Chordin-like 2, Brorin, and Brorin-like contain only two or three cysteine-rich domains. Although their mechanisms of action remain unclear, they might be distinct from that of Chordin. The expression profiles of these genes in mice and zebrafish indicate unique roles at embryonic and postnatal stages. Mutant/knockdown mouse and zebrafish phenotypes indicate roles in morphogenesis during gastrulation, dorsoventral axis formation, ear, pharyngeal, and neural development, and venous and arterial patterning. Aberrant Chordin expression might result in hereditary diseases and cancer. In addition, altered serum Chordin and Chordin-like 1 levels are also observed in non-hereditary diseases. Together, these results indicate pathophysiological roles. | ||
533 | |f Walter de Gruyter Online Zeitschriften | ||
650 | 4 | |a bone morphogenetic protein | |
650 | 4 | |a Chordin | |
650 | 4 | |a development | |
650 | 4 | |a disease | |
650 | 4 | |a evolution | |
700 | 1 | |a Ohta, Hiroya |e verfasserin |4 aut | |
773 | 0 | 8 | |i Enthalten in |t Biomolecular concepts |d Berlin : de Gruyter, 2010 |g 1(2010), 3-4 vom: 30. Sept., Seite 297-304 |w (DE-627)NLEJ248235141 |w (DE-600)2558921-0 |x 1868-503X |7 nnns |
773 | 1 | 8 | |g volume:1 |g year:2010 |g number:3-4 |g day:30 |g month:09 |g pages:297-304 |g extent:8 |
856 | 4 | 0 | |u https://doi.org/10.1515/bmc.2010.026 |z Deutschlandweit zugänglich |
912 | |a GBV_USEFLAG_U | ||
912 | |a ZDB-1-DGR | ||
912 | |a GBV_NL_ARTICLE | ||
951 | |a AR | ||
952 | |d 1 |j 2010 |e 3-4 |b 30 |c 09 |h 297-304 |g 8 |
author_variant |
n i ni h o ho |
---|---|
matchkey_str |
article:1868503X:2010----::ertdoeopoeeipoennaoito |
hierarchy_sort_str |
2010 |
publishDate |
2010 |
allfields |
10.1515/bmc.2010.026 doi artikel_Grundlieferung.pp (DE-627)NLEJ246606991 DE-627 ger DE-627 rakwb Itoh, Nobuyuki verfasserin aut Secreted bone morphogenetic protein antagonists of the Chordin family Walter de Gruyter 2010 8 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier ©2010 by Walter de Gruyter Berlin New York Chordin, Chordin-like 1, and Chordin-like 2 are secreted bone morphogenetic protein (BMP) antagonists with highly conserved Chordin-like cysteine-rich domains. Recently, Brorin and Brorin-like have been identified as new Chordin-like BMP antagonists. A Chordin ortholog, Short gastrulation, has been identified in Drosophila, a protostome, but not other orthologs. By contrast, Chordin, Chordin-like 1, and Chordin-like 2 have been identified in Ciona intestinalis, the closest living relatives of the vertebrates, but Brorin and Brorin-like have not. However, all these genes have been identified in most vertebrates. These results indicate that Chordin, Chordin-like 1, and Chordin-like 2 were generated early in the metazoan lineage. Later on, Brorin and Brorin-like were potentially generated by a genome duplication event in early vertebrate evolution. All four cysteine-rich domains of Chordin are essential for the regulation of its action. However, Chordin-like 1, Chordin-like 2, Brorin, and Brorin-like contain only two or three cysteine-rich domains. Although their mechanisms of action remain unclear, they might be distinct from that of Chordin. The expression profiles of these genes in mice and zebrafish indicate unique roles at embryonic and postnatal stages. Mutant/knockdown mouse and zebrafish phenotypes indicate roles in morphogenesis during gastrulation, dorsoventral axis formation, ear, pharyngeal, and neural development, and venous and arterial patterning. Aberrant Chordin expression might result in hereditary diseases and cancer. In addition, altered serum Chordin and Chordin-like 1 levels are also observed in non-hereditary diseases. Together, these results indicate pathophysiological roles. Walter de Gruyter Online Zeitschriften bone morphogenetic protein Chordin development disease evolution Ohta, Hiroya verfasserin aut Enthalten in Biomolecular concepts Berlin : de Gruyter, 2010 1(2010), 3-4 vom: 30. Sept., Seite 297-304 (DE-627)NLEJ248235141 (DE-600)2558921-0 1868-503X nnns volume:1 year:2010 number:3-4 day:30 month:09 pages:297-304 extent:8 https://doi.org/10.1515/bmc.2010.026 Deutschlandweit zugänglich GBV_USEFLAG_U ZDB-1-DGR GBV_NL_ARTICLE AR 1 2010 3-4 30 09 297-304 8 |
spelling |
10.1515/bmc.2010.026 doi artikel_Grundlieferung.pp (DE-627)NLEJ246606991 DE-627 ger DE-627 rakwb Itoh, Nobuyuki verfasserin aut Secreted bone morphogenetic protein antagonists of the Chordin family Walter de Gruyter 2010 8 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier ©2010 by Walter de Gruyter Berlin New York Chordin, Chordin-like 1, and Chordin-like 2 are secreted bone morphogenetic protein (BMP) antagonists with highly conserved Chordin-like cysteine-rich domains. Recently, Brorin and Brorin-like have been identified as new Chordin-like BMP antagonists. A Chordin ortholog, Short gastrulation, has been identified in Drosophila, a protostome, but not other orthologs. By contrast, Chordin, Chordin-like 1, and Chordin-like 2 have been identified in Ciona intestinalis, the closest living relatives of the vertebrates, but Brorin and Brorin-like have not. However, all these genes have been identified in most vertebrates. These results indicate that Chordin, Chordin-like 1, and Chordin-like 2 were generated early in the metazoan lineage. Later on, Brorin and Brorin-like were potentially generated by a genome duplication event in early vertebrate evolution. All four cysteine-rich domains of Chordin are essential for the regulation of its action. However, Chordin-like 1, Chordin-like 2, Brorin, and Brorin-like contain only two or three cysteine-rich domains. Although their mechanisms of action remain unclear, they might be distinct from that of Chordin. The expression profiles of these genes in mice and zebrafish indicate unique roles at embryonic and postnatal stages. Mutant/knockdown mouse and zebrafish phenotypes indicate roles in morphogenesis during gastrulation, dorsoventral axis formation, ear, pharyngeal, and neural development, and venous and arterial patterning. Aberrant Chordin expression might result in hereditary diseases and cancer. In addition, altered serum Chordin and Chordin-like 1 levels are also observed in non-hereditary diseases. Together, these results indicate pathophysiological roles. Walter de Gruyter Online Zeitschriften bone morphogenetic protein Chordin development disease evolution Ohta, Hiroya verfasserin aut Enthalten in Biomolecular concepts Berlin : de Gruyter, 2010 1(2010), 3-4 vom: 30. Sept., Seite 297-304 (DE-627)NLEJ248235141 (DE-600)2558921-0 1868-503X nnns volume:1 year:2010 number:3-4 day:30 month:09 pages:297-304 extent:8 https://doi.org/10.1515/bmc.2010.026 Deutschlandweit zugänglich GBV_USEFLAG_U ZDB-1-DGR GBV_NL_ARTICLE AR 1 2010 3-4 30 09 297-304 8 |
allfields_unstemmed |
10.1515/bmc.2010.026 doi artikel_Grundlieferung.pp (DE-627)NLEJ246606991 DE-627 ger DE-627 rakwb Itoh, Nobuyuki verfasserin aut Secreted bone morphogenetic protein antagonists of the Chordin family Walter de Gruyter 2010 8 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier ©2010 by Walter de Gruyter Berlin New York Chordin, Chordin-like 1, and Chordin-like 2 are secreted bone morphogenetic protein (BMP) antagonists with highly conserved Chordin-like cysteine-rich domains. Recently, Brorin and Brorin-like have been identified as new Chordin-like BMP antagonists. A Chordin ortholog, Short gastrulation, has been identified in Drosophila, a protostome, but not other orthologs. By contrast, Chordin, Chordin-like 1, and Chordin-like 2 have been identified in Ciona intestinalis, the closest living relatives of the vertebrates, but Brorin and Brorin-like have not. However, all these genes have been identified in most vertebrates. These results indicate that Chordin, Chordin-like 1, and Chordin-like 2 were generated early in the metazoan lineage. Later on, Brorin and Brorin-like were potentially generated by a genome duplication event in early vertebrate evolution. All four cysteine-rich domains of Chordin are essential for the regulation of its action. However, Chordin-like 1, Chordin-like 2, Brorin, and Brorin-like contain only two or three cysteine-rich domains. Although their mechanisms of action remain unclear, they might be distinct from that of Chordin. The expression profiles of these genes in mice and zebrafish indicate unique roles at embryonic and postnatal stages. Mutant/knockdown mouse and zebrafish phenotypes indicate roles in morphogenesis during gastrulation, dorsoventral axis formation, ear, pharyngeal, and neural development, and venous and arterial patterning. Aberrant Chordin expression might result in hereditary diseases and cancer. In addition, altered serum Chordin and Chordin-like 1 levels are also observed in non-hereditary diseases. Together, these results indicate pathophysiological roles. Walter de Gruyter Online Zeitschriften bone morphogenetic protein Chordin development disease evolution Ohta, Hiroya verfasserin aut Enthalten in Biomolecular concepts Berlin : de Gruyter, 2010 1(2010), 3-4 vom: 30. Sept., Seite 297-304 (DE-627)NLEJ248235141 (DE-600)2558921-0 1868-503X nnns volume:1 year:2010 number:3-4 day:30 month:09 pages:297-304 extent:8 https://doi.org/10.1515/bmc.2010.026 Deutschlandweit zugänglich GBV_USEFLAG_U ZDB-1-DGR GBV_NL_ARTICLE AR 1 2010 3-4 30 09 297-304 8 |
allfieldsGer |
10.1515/bmc.2010.026 doi artikel_Grundlieferung.pp (DE-627)NLEJ246606991 DE-627 ger DE-627 rakwb Itoh, Nobuyuki verfasserin aut Secreted bone morphogenetic protein antagonists of the Chordin family Walter de Gruyter 2010 8 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier ©2010 by Walter de Gruyter Berlin New York Chordin, Chordin-like 1, and Chordin-like 2 are secreted bone morphogenetic protein (BMP) antagonists with highly conserved Chordin-like cysteine-rich domains. Recently, Brorin and Brorin-like have been identified as new Chordin-like BMP antagonists. A Chordin ortholog, Short gastrulation, has been identified in Drosophila, a protostome, but not other orthologs. By contrast, Chordin, Chordin-like 1, and Chordin-like 2 have been identified in Ciona intestinalis, the closest living relatives of the vertebrates, but Brorin and Brorin-like have not. However, all these genes have been identified in most vertebrates. These results indicate that Chordin, Chordin-like 1, and Chordin-like 2 were generated early in the metazoan lineage. Later on, Brorin and Brorin-like were potentially generated by a genome duplication event in early vertebrate evolution. All four cysteine-rich domains of Chordin are essential for the regulation of its action. However, Chordin-like 1, Chordin-like 2, Brorin, and Brorin-like contain only two or three cysteine-rich domains. Although their mechanisms of action remain unclear, they might be distinct from that of Chordin. The expression profiles of these genes in mice and zebrafish indicate unique roles at embryonic and postnatal stages. Mutant/knockdown mouse and zebrafish phenotypes indicate roles in morphogenesis during gastrulation, dorsoventral axis formation, ear, pharyngeal, and neural development, and venous and arterial patterning. Aberrant Chordin expression might result in hereditary diseases and cancer. In addition, altered serum Chordin and Chordin-like 1 levels are also observed in non-hereditary diseases. Together, these results indicate pathophysiological roles. Walter de Gruyter Online Zeitschriften bone morphogenetic protein Chordin development disease evolution Ohta, Hiroya verfasserin aut Enthalten in Biomolecular concepts Berlin : de Gruyter, 2010 1(2010), 3-4 vom: 30. Sept., Seite 297-304 (DE-627)NLEJ248235141 (DE-600)2558921-0 1868-503X nnns volume:1 year:2010 number:3-4 day:30 month:09 pages:297-304 extent:8 https://doi.org/10.1515/bmc.2010.026 Deutschlandweit zugänglich GBV_USEFLAG_U ZDB-1-DGR GBV_NL_ARTICLE AR 1 2010 3-4 30 09 297-304 8 |
allfieldsSound |
10.1515/bmc.2010.026 doi artikel_Grundlieferung.pp (DE-627)NLEJ246606991 DE-627 ger DE-627 rakwb Itoh, Nobuyuki verfasserin aut Secreted bone morphogenetic protein antagonists of the Chordin family Walter de Gruyter 2010 8 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier ©2010 by Walter de Gruyter Berlin New York Chordin, Chordin-like 1, and Chordin-like 2 are secreted bone morphogenetic protein (BMP) antagonists with highly conserved Chordin-like cysteine-rich domains. Recently, Brorin and Brorin-like have been identified as new Chordin-like BMP antagonists. A Chordin ortholog, Short gastrulation, has been identified in Drosophila, a protostome, but not other orthologs. By contrast, Chordin, Chordin-like 1, and Chordin-like 2 have been identified in Ciona intestinalis, the closest living relatives of the vertebrates, but Brorin and Brorin-like have not. However, all these genes have been identified in most vertebrates. These results indicate that Chordin, Chordin-like 1, and Chordin-like 2 were generated early in the metazoan lineage. Later on, Brorin and Brorin-like were potentially generated by a genome duplication event in early vertebrate evolution. All four cysteine-rich domains of Chordin are essential for the regulation of its action. However, Chordin-like 1, Chordin-like 2, Brorin, and Brorin-like contain only two or three cysteine-rich domains. Although their mechanisms of action remain unclear, they might be distinct from that of Chordin. The expression profiles of these genes in mice and zebrafish indicate unique roles at embryonic and postnatal stages. Mutant/knockdown mouse and zebrafish phenotypes indicate roles in morphogenesis during gastrulation, dorsoventral axis formation, ear, pharyngeal, and neural development, and venous and arterial patterning. Aberrant Chordin expression might result in hereditary diseases and cancer. In addition, altered serum Chordin and Chordin-like 1 levels are also observed in non-hereditary diseases. Together, these results indicate pathophysiological roles. Walter de Gruyter Online Zeitschriften bone morphogenetic protein Chordin development disease evolution Ohta, Hiroya verfasserin aut Enthalten in Biomolecular concepts Berlin : de Gruyter, 2010 1(2010), 3-4 vom: 30. Sept., Seite 297-304 (DE-627)NLEJ248235141 (DE-600)2558921-0 1868-503X nnns volume:1 year:2010 number:3-4 day:30 month:09 pages:297-304 extent:8 https://doi.org/10.1515/bmc.2010.026 Deutschlandweit zugänglich GBV_USEFLAG_U ZDB-1-DGR GBV_NL_ARTICLE AR 1 2010 3-4 30 09 297-304 8 |
source |
Enthalten in Biomolecular concepts 1(2010), 3-4 vom: 30. Sept., Seite 297-304 volume:1 year:2010 number:3-4 day:30 month:09 pages:297-304 extent:8 |
sourceStr |
Enthalten in Biomolecular concepts 1(2010), 3-4 vom: 30. Sept., Seite 297-304 volume:1 year:2010 number:3-4 day:30 month:09 pages:297-304 extent:8 |
format_phy_str_mv |
Article |
institution |
findex.gbv.de |
topic_facet |
bone morphogenetic protein Chordin development disease evolution |
isfreeaccess_bool |
false |
container_title |
Biomolecular concepts |
authorswithroles_txt_mv |
Itoh, Nobuyuki @@aut@@ Ohta, Hiroya @@aut@@ |
publishDateDaySort_date |
2010-09-30T00:00:00Z |
hierarchy_top_id |
NLEJ248235141 |
id |
NLEJ246606991 |
fullrecord |
<?xml version="1.0" encoding="UTF-8"?><collection xmlns="http://www.loc.gov/MARC21/slim"><record><leader>01000caa a22002652 4500</leader><controlfield tag="001">NLEJ246606991</controlfield><controlfield tag="003">DE-627</controlfield><controlfield tag="005">20230505195025.0</controlfield><controlfield tag="007">cr uuu---uuuuu</controlfield><controlfield tag="008">220814s2010 xx |||||o 00| ||und c</controlfield><datafield tag="024" ind1="7" ind2=" "><subfield code="a">10.1515/bmc.2010.026</subfield><subfield code="2">doi</subfield></datafield><datafield tag="028" ind1="5" ind2="2"><subfield code="a">artikel_Grundlieferung.pp</subfield></datafield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(DE-627)NLEJ246606991</subfield></datafield><datafield tag="040" ind1=" " ind2=" "><subfield code="a">DE-627</subfield><subfield code="b">ger</subfield><subfield code="c">DE-627</subfield><subfield code="e">rakwb</subfield></datafield><datafield tag="100" ind1="1" ind2=" "><subfield code="a">Itoh, Nobuyuki</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="245" ind1="1" ind2="0"><subfield code="a">Secreted bone morphogenetic protein antagonists of the Chordin family</subfield></datafield><datafield tag="264" ind1=" " ind2="1"><subfield code="b">Walter de Gruyter</subfield><subfield code="c">2010</subfield></datafield><datafield tag="300" ind1=" " ind2=" "><subfield code="a">8</subfield></datafield><datafield tag="336" ind1=" " ind2=" "><subfield code="a">Text</subfield><subfield code="b">txt</subfield><subfield code="2">rdacontent</subfield></datafield><datafield tag="337" ind1=" " ind2=" "><subfield code="a">Computermedien</subfield><subfield code="b">c</subfield><subfield code="2">rdamedia</subfield></datafield><datafield tag="338" ind1=" " ind2=" "><subfield code="a">Online-Ressource</subfield><subfield code="b">cr</subfield><subfield code="2">rdacarrier</subfield></datafield><datafield tag="500" ind1=" " ind2=" "><subfield code="a">©2010 by Walter de Gruyter Berlin New York</subfield></datafield><datafield tag="520" ind1=" " ind2=" "><subfield code="a">Chordin, Chordin-like 1, and Chordin-like 2 are secreted bone morphogenetic protein (BMP) antagonists with highly conserved Chordin-like cysteine-rich domains. Recently, Brorin and Brorin-like have been identified as new Chordin-like BMP antagonists. A Chordin ortholog, Short gastrulation, has been identified in Drosophila, a protostome, but not other orthologs. By contrast, Chordin, Chordin-like 1, and Chordin-like 2 have been identified in Ciona intestinalis, the closest living relatives of the vertebrates, but Brorin and Brorin-like have not. However, all these genes have been identified in most vertebrates. These results indicate that Chordin, Chordin-like 1, and Chordin-like 2 were generated early in the metazoan lineage. Later on, Brorin and Brorin-like were potentially generated by a genome duplication event in early vertebrate evolution. All four cysteine-rich domains of Chordin are essential for the regulation of its action. However, Chordin-like 1, Chordin-like 2, Brorin, and Brorin-like contain only two or three cysteine-rich domains. Although their mechanisms of action remain unclear, they might be distinct from that of Chordin. The expression profiles of these genes in mice and zebrafish indicate unique roles at embryonic and postnatal stages. Mutant/knockdown mouse and zebrafish phenotypes indicate roles in morphogenesis during gastrulation, dorsoventral axis formation, ear, pharyngeal, and neural development, and venous and arterial patterning. Aberrant Chordin expression might result in hereditary diseases and cancer. In addition, altered serum Chordin and Chordin-like 1 levels are also observed in non-hereditary diseases. Together, these results indicate pathophysiological roles.</subfield></datafield><datafield tag="533" ind1=" " ind2=" "><subfield code="f">Walter de Gruyter Online Zeitschriften</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">bone morphogenetic protein</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Chordin</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">development</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">disease</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">evolution</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Ohta, Hiroya</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="773" ind1="0" ind2="8"><subfield code="i">Enthalten in</subfield><subfield code="t">Biomolecular concepts</subfield><subfield code="d">Berlin : de Gruyter, 2010</subfield><subfield code="g">1(2010), 3-4 vom: 30. Sept., Seite 297-304</subfield><subfield code="w">(DE-627)NLEJ248235141</subfield><subfield code="w">(DE-600)2558921-0</subfield><subfield code="x">1868-503X</subfield><subfield code="7">nnns</subfield></datafield><datafield tag="773" ind1="1" ind2="8"><subfield code="g">volume:1</subfield><subfield code="g">year:2010</subfield><subfield code="g">number:3-4</subfield><subfield code="g">day:30</subfield><subfield code="g">month:09</subfield><subfield code="g">pages:297-304</subfield><subfield code="g">extent:8</subfield></datafield><datafield tag="856" ind1="4" ind2="0"><subfield code="u">https://doi.org/10.1515/bmc.2010.026</subfield><subfield code="z">Deutschlandweit zugänglich</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_USEFLAG_U</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">ZDB-1-DGR</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_NL_ARTICLE</subfield></datafield><datafield tag="951" ind1=" " ind2=" "><subfield code="a">AR</subfield></datafield><datafield tag="952" ind1=" " ind2=" "><subfield code="d">1</subfield><subfield code="j">2010</subfield><subfield code="e">3-4</subfield><subfield code="b">30</subfield><subfield code="c">09</subfield><subfield code="h">297-304</subfield><subfield code="g">8</subfield></datafield></record></collection>
|
series2 |
Walter de Gruyter Online Zeitschriften |
author |
Itoh, Nobuyuki |
spellingShingle |
Itoh, Nobuyuki misc bone morphogenetic protein misc Chordin misc development misc disease misc evolution Secreted bone morphogenetic protein antagonists of the Chordin family |
authorStr |
Itoh, Nobuyuki |
ppnlink_with_tag_str_mv |
@@773@@(DE-627)NLEJ248235141 |
format |
electronic Article |
delete_txt_mv |
keep |
author_role |
aut aut |
collection |
NL |
remote_str |
true |
illustrated |
Not Illustrated |
issn |
1868-503X |
topic_title |
Secreted bone morphogenetic protein antagonists of the Chordin family bone morphogenetic protein Chordin development disease evolution |
publisher |
Walter de Gruyter |
publisherStr |
Walter de Gruyter |
topic |
misc bone morphogenetic protein misc Chordin misc development misc disease misc evolution |
topic_unstemmed |
misc bone morphogenetic protein misc Chordin misc development misc disease misc evolution |
topic_browse |
misc bone morphogenetic protein misc Chordin misc development misc disease misc evolution |
format_facet |
Elektronische Aufsätze Aufsätze Elektronische Ressource |
format_main_str_mv |
Text Zeitschrift/Artikel |
carriertype_str_mv |
cr |
hierarchy_parent_title |
Biomolecular concepts |
hierarchy_parent_id |
NLEJ248235141 |
hierarchy_top_title |
Biomolecular concepts |
isfreeaccess_txt |
false |
familylinks_str_mv |
(DE-627)NLEJ248235141 (DE-600)2558921-0 |
title |
Secreted bone morphogenetic protein antagonists of the Chordin family |
ctrlnum |
(DE-627)NLEJ246606991 |
title_full |
Secreted bone morphogenetic protein antagonists of the Chordin family |
author_sort |
Itoh, Nobuyuki |
journal |
Biomolecular concepts |
journalStr |
Biomolecular concepts |
isOA_bool |
false |
recordtype |
marc |
publishDateSort |
2010 |
contenttype_str_mv |
txt |
container_start_page |
297 |
author_browse |
Itoh, Nobuyuki Ohta, Hiroya |
container_volume |
1 |
physical |
8 |
format_se |
Elektronische Aufsätze |
author-letter |
Itoh, Nobuyuki |
doi_str_mv |
10.1515/bmc.2010.026 |
author2-role |
verfasserin |
title_sort |
secreted bone morphogenetic protein antagonists of the chordin family |
title_auth |
Secreted bone morphogenetic protein antagonists of the Chordin family |
abstract |
Chordin, Chordin-like 1, and Chordin-like 2 are secreted bone morphogenetic protein (BMP) antagonists with highly conserved Chordin-like cysteine-rich domains. Recently, Brorin and Brorin-like have been identified as new Chordin-like BMP antagonists. A Chordin ortholog, Short gastrulation, has been identified in Drosophila, a protostome, but not other orthologs. By contrast, Chordin, Chordin-like 1, and Chordin-like 2 have been identified in Ciona intestinalis, the closest living relatives of the vertebrates, but Brorin and Brorin-like have not. However, all these genes have been identified in most vertebrates. These results indicate that Chordin, Chordin-like 1, and Chordin-like 2 were generated early in the metazoan lineage. Later on, Brorin and Brorin-like were potentially generated by a genome duplication event in early vertebrate evolution. All four cysteine-rich domains of Chordin are essential for the regulation of its action. However, Chordin-like 1, Chordin-like 2, Brorin, and Brorin-like contain only two or three cysteine-rich domains. Although their mechanisms of action remain unclear, they might be distinct from that of Chordin. The expression profiles of these genes in mice and zebrafish indicate unique roles at embryonic and postnatal stages. Mutant/knockdown mouse and zebrafish phenotypes indicate roles in morphogenesis during gastrulation, dorsoventral axis formation, ear, pharyngeal, and neural development, and venous and arterial patterning. Aberrant Chordin expression might result in hereditary diseases and cancer. In addition, altered serum Chordin and Chordin-like 1 levels are also observed in non-hereditary diseases. Together, these results indicate pathophysiological roles. ©2010 by Walter de Gruyter Berlin New York |
abstractGer |
Chordin, Chordin-like 1, and Chordin-like 2 are secreted bone morphogenetic protein (BMP) antagonists with highly conserved Chordin-like cysteine-rich domains. Recently, Brorin and Brorin-like have been identified as new Chordin-like BMP antagonists. A Chordin ortholog, Short gastrulation, has been identified in Drosophila, a protostome, but not other orthologs. By contrast, Chordin, Chordin-like 1, and Chordin-like 2 have been identified in Ciona intestinalis, the closest living relatives of the vertebrates, but Brorin and Brorin-like have not. However, all these genes have been identified in most vertebrates. These results indicate that Chordin, Chordin-like 1, and Chordin-like 2 were generated early in the metazoan lineage. Later on, Brorin and Brorin-like were potentially generated by a genome duplication event in early vertebrate evolution. All four cysteine-rich domains of Chordin are essential for the regulation of its action. However, Chordin-like 1, Chordin-like 2, Brorin, and Brorin-like contain only two or three cysteine-rich domains. Although their mechanisms of action remain unclear, they might be distinct from that of Chordin. The expression profiles of these genes in mice and zebrafish indicate unique roles at embryonic and postnatal stages. Mutant/knockdown mouse and zebrafish phenotypes indicate roles in morphogenesis during gastrulation, dorsoventral axis formation, ear, pharyngeal, and neural development, and venous and arterial patterning. Aberrant Chordin expression might result in hereditary diseases and cancer. In addition, altered serum Chordin and Chordin-like 1 levels are also observed in non-hereditary diseases. Together, these results indicate pathophysiological roles. ©2010 by Walter de Gruyter Berlin New York |
abstract_unstemmed |
Chordin, Chordin-like 1, and Chordin-like 2 are secreted bone morphogenetic protein (BMP) antagonists with highly conserved Chordin-like cysteine-rich domains. Recently, Brorin and Brorin-like have been identified as new Chordin-like BMP antagonists. A Chordin ortholog, Short gastrulation, has been identified in Drosophila, a protostome, but not other orthologs. By contrast, Chordin, Chordin-like 1, and Chordin-like 2 have been identified in Ciona intestinalis, the closest living relatives of the vertebrates, but Brorin and Brorin-like have not. However, all these genes have been identified in most vertebrates. These results indicate that Chordin, Chordin-like 1, and Chordin-like 2 were generated early in the metazoan lineage. Later on, Brorin and Brorin-like were potentially generated by a genome duplication event in early vertebrate evolution. All four cysteine-rich domains of Chordin are essential for the regulation of its action. However, Chordin-like 1, Chordin-like 2, Brorin, and Brorin-like contain only two or three cysteine-rich domains. Although their mechanisms of action remain unclear, they might be distinct from that of Chordin. The expression profiles of these genes in mice and zebrafish indicate unique roles at embryonic and postnatal stages. Mutant/knockdown mouse and zebrafish phenotypes indicate roles in morphogenesis during gastrulation, dorsoventral axis formation, ear, pharyngeal, and neural development, and venous and arterial patterning. Aberrant Chordin expression might result in hereditary diseases and cancer. In addition, altered serum Chordin and Chordin-like 1 levels are also observed in non-hereditary diseases. Together, these results indicate pathophysiological roles. ©2010 by Walter de Gruyter Berlin New York |
collection_details |
GBV_USEFLAG_U ZDB-1-DGR GBV_NL_ARTICLE |
container_issue |
3-4 |
title_short |
Secreted bone morphogenetic protein antagonists of the Chordin family |
url |
https://doi.org/10.1515/bmc.2010.026 |
remote_bool |
true |
author2 |
Ohta, Hiroya |
author2Str |
Ohta, Hiroya |
ppnlink |
NLEJ248235141 |
mediatype_str_mv |
c |
isOA_txt |
false |
hochschulschrift_bool |
false |
doi_str |
10.1515/bmc.2010.026 |
up_date |
2024-07-06T08:52:40.380Z |
_version_ |
1803819113912467456 |
fullrecord_marcxml |
<?xml version="1.0" encoding="UTF-8"?><collection xmlns="http://www.loc.gov/MARC21/slim"><record><leader>01000caa a22002652 4500</leader><controlfield tag="001">NLEJ246606991</controlfield><controlfield tag="003">DE-627</controlfield><controlfield tag="005">20230505195025.0</controlfield><controlfield tag="007">cr uuu---uuuuu</controlfield><controlfield tag="008">220814s2010 xx |||||o 00| ||und c</controlfield><datafield tag="024" ind1="7" ind2=" "><subfield code="a">10.1515/bmc.2010.026</subfield><subfield code="2">doi</subfield></datafield><datafield tag="028" ind1="5" ind2="2"><subfield code="a">artikel_Grundlieferung.pp</subfield></datafield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(DE-627)NLEJ246606991</subfield></datafield><datafield tag="040" ind1=" " ind2=" "><subfield code="a">DE-627</subfield><subfield code="b">ger</subfield><subfield code="c">DE-627</subfield><subfield code="e">rakwb</subfield></datafield><datafield tag="100" ind1="1" ind2=" "><subfield code="a">Itoh, Nobuyuki</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="245" ind1="1" ind2="0"><subfield code="a">Secreted bone morphogenetic protein antagonists of the Chordin family</subfield></datafield><datafield tag="264" ind1=" " ind2="1"><subfield code="b">Walter de Gruyter</subfield><subfield code="c">2010</subfield></datafield><datafield tag="300" ind1=" " ind2=" "><subfield code="a">8</subfield></datafield><datafield tag="336" ind1=" " ind2=" "><subfield code="a">Text</subfield><subfield code="b">txt</subfield><subfield code="2">rdacontent</subfield></datafield><datafield tag="337" ind1=" " ind2=" "><subfield code="a">Computermedien</subfield><subfield code="b">c</subfield><subfield code="2">rdamedia</subfield></datafield><datafield tag="338" ind1=" " ind2=" "><subfield code="a">Online-Ressource</subfield><subfield code="b">cr</subfield><subfield code="2">rdacarrier</subfield></datafield><datafield tag="500" ind1=" " ind2=" "><subfield code="a">©2010 by Walter de Gruyter Berlin New York</subfield></datafield><datafield tag="520" ind1=" " ind2=" "><subfield code="a">Chordin, Chordin-like 1, and Chordin-like 2 are secreted bone morphogenetic protein (BMP) antagonists with highly conserved Chordin-like cysteine-rich domains. Recently, Brorin and Brorin-like have been identified as new Chordin-like BMP antagonists. A Chordin ortholog, Short gastrulation, has been identified in Drosophila, a protostome, but not other orthologs. By contrast, Chordin, Chordin-like 1, and Chordin-like 2 have been identified in Ciona intestinalis, the closest living relatives of the vertebrates, but Brorin and Brorin-like have not. However, all these genes have been identified in most vertebrates. These results indicate that Chordin, Chordin-like 1, and Chordin-like 2 were generated early in the metazoan lineage. Later on, Brorin and Brorin-like were potentially generated by a genome duplication event in early vertebrate evolution. All four cysteine-rich domains of Chordin are essential for the regulation of its action. However, Chordin-like 1, Chordin-like 2, Brorin, and Brorin-like contain only two or three cysteine-rich domains. Although their mechanisms of action remain unclear, they might be distinct from that of Chordin. The expression profiles of these genes in mice and zebrafish indicate unique roles at embryonic and postnatal stages. Mutant/knockdown mouse and zebrafish phenotypes indicate roles in morphogenesis during gastrulation, dorsoventral axis formation, ear, pharyngeal, and neural development, and venous and arterial patterning. Aberrant Chordin expression might result in hereditary diseases and cancer. In addition, altered serum Chordin and Chordin-like 1 levels are also observed in non-hereditary diseases. Together, these results indicate pathophysiological roles.</subfield></datafield><datafield tag="533" ind1=" " ind2=" "><subfield code="f">Walter de Gruyter Online Zeitschriften</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">bone morphogenetic protein</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Chordin</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">development</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">disease</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">evolution</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Ohta, Hiroya</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="773" ind1="0" ind2="8"><subfield code="i">Enthalten in</subfield><subfield code="t">Biomolecular concepts</subfield><subfield code="d">Berlin : de Gruyter, 2010</subfield><subfield code="g">1(2010), 3-4 vom: 30. Sept., Seite 297-304</subfield><subfield code="w">(DE-627)NLEJ248235141</subfield><subfield code="w">(DE-600)2558921-0</subfield><subfield code="x">1868-503X</subfield><subfield code="7">nnns</subfield></datafield><datafield tag="773" ind1="1" ind2="8"><subfield code="g">volume:1</subfield><subfield code="g">year:2010</subfield><subfield code="g">number:3-4</subfield><subfield code="g">day:30</subfield><subfield code="g">month:09</subfield><subfield code="g">pages:297-304</subfield><subfield code="g">extent:8</subfield></datafield><datafield tag="856" ind1="4" ind2="0"><subfield code="u">https://doi.org/10.1515/bmc.2010.026</subfield><subfield code="z">Deutschlandweit zugänglich</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_USEFLAG_U</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">ZDB-1-DGR</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_NL_ARTICLE</subfield></datafield><datafield tag="951" ind1=" " ind2=" "><subfield code="a">AR</subfield></datafield><datafield tag="952" ind1=" " ind2=" "><subfield code="d">1</subfield><subfield code="j">2010</subfield><subfield code="e">3-4</subfield><subfield code="b">30</subfield><subfield code="c">09</subfield><subfield code="h">297-304</subfield><subfield code="g">8</subfield></datafield></record></collection>
|
score |
7.4007587 |