Epigenetherapy, a new concept
Small RNAs have been shown to regulate gene transcription by interacting with the promoter region and modifying the histone code. The exact mechanism of function is still unclear but the feasibility to activate or repress endogenous gene expression with small RNA molecules has already been demonstra...
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| Format: |
E-Artikel |
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| Erschienen: |
Walter de Gruyter ; 2011 |
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| Schlagwörter: |
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| Anmerkung: |
©2011 by Walter de Gruyter Berlin Boston |
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| Umfang: |
8 |
| Reproduktion: |
Walter de Gruyter Online Zeitschriften |
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| Übergeordnetes Werk: |
Enthalten in: Biomolecular concepts - Berlin : de Gruyter, 2010, 2(2011), 3 vom: 20. Apr., Seite 127-134 |
| Übergeordnetes Werk: |
volume:2 ; year:2011 ; number:3 ; day:20 ; month:04 ; pages:127-134 ; extent:8 |
| Links: |
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| DOI / URN: |
10.1515/bmc.2011.012 |
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10.1515/bmc.2011.012 doi artikel_Grundlieferung.pp (DE-627)NLEJ246607238 DE-627 ger DE-627 rakwb Epigenetherapy, a new concept Walter de Gruyter 2011 8 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier ©2011 by Walter de Gruyter Berlin Boston Small RNAs have been shown to regulate gene transcription by interacting with the promoter region and modifying the histone code. The exact mechanism of function is still unclear but the feasibility to activate or repress endogenous gene expression with small RNA molecules has already been demonstrated in vitro and in vivo. In traditional gene therapy non-mutated or otherwise useful genes are inserted into patient's cells to treat a disease. In epigenetherapy the action of small RNAs is utilized by delivering only the small RNAs to patient's cells where they then regulate gene expression by epigenetic mechanisms. This method could be widely useful not only for basic research but also for clinical applications of small RNAs. Walter de Gruyter Online Zeitschriften epigenetics gene therapy miRNA siRNA small RNAs Husso, Tiia oth Turunen, Mikko P. oth Parker, Nigel oth Ylä-Herttuala, Seppo oth Enthalten in Biomolecular concepts Berlin : de Gruyter, 2010 2(2011), 3 vom: 20. Apr., Seite 127-134 (DE-627)NLEJ248235141 (DE-600)2558921-0 1868-503X nnns volume:2 year:2011 number:3 day:20 month:04 pages:127-134 extent:8 https://doi.org/10.1515/bmc.2011.012 Deutschlandweit zugänglich GBV_USEFLAG_U ZDB-1-DGR GBV_NL_ARTICLE AR 2 2011 3 20 04 127-134 8 |
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10.1515/bmc.2011.012 doi artikel_Grundlieferung.pp (DE-627)NLEJ246607238 DE-627 ger DE-627 rakwb Epigenetherapy, a new concept Walter de Gruyter 2011 8 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier ©2011 by Walter de Gruyter Berlin Boston Small RNAs have been shown to regulate gene transcription by interacting with the promoter region and modifying the histone code. The exact mechanism of function is still unclear but the feasibility to activate or repress endogenous gene expression with small RNA molecules has already been demonstrated in vitro and in vivo. In traditional gene therapy non-mutated or otherwise useful genes are inserted into patient's cells to treat a disease. In epigenetherapy the action of small RNAs is utilized by delivering only the small RNAs to patient's cells where they then regulate gene expression by epigenetic mechanisms. This method could be widely useful not only for basic research but also for clinical applications of small RNAs. Walter de Gruyter Online Zeitschriften epigenetics gene therapy miRNA siRNA small RNAs Husso, Tiia oth Turunen, Mikko P. oth Parker, Nigel oth Ylä-Herttuala, Seppo oth Enthalten in Biomolecular concepts Berlin : de Gruyter, 2010 2(2011), 3 vom: 20. Apr., Seite 127-134 (DE-627)NLEJ248235141 (DE-600)2558921-0 1868-503X nnns volume:2 year:2011 number:3 day:20 month:04 pages:127-134 extent:8 https://doi.org/10.1515/bmc.2011.012 Deutschlandweit zugänglich GBV_USEFLAG_U ZDB-1-DGR GBV_NL_ARTICLE AR 2 2011 3 20 04 127-134 8 |
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Small RNAs have been shown to regulate gene transcription by interacting with the promoter region and modifying the histone code. The exact mechanism of function is still unclear but the feasibility to activate or repress endogenous gene expression with small RNA molecules has already been demonstrated in vitro and in vivo. In traditional gene therapy non-mutated or otherwise useful genes are inserted into patient's cells to treat a disease. In epigenetherapy the action of small RNAs is utilized by delivering only the small RNAs to patient's cells where they then regulate gene expression by epigenetic mechanisms. This method could be widely useful not only for basic research but also for clinical applications of small RNAs. ©2011 by Walter de Gruyter Berlin Boston |
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Small RNAs have been shown to regulate gene transcription by interacting with the promoter region and modifying the histone code. The exact mechanism of function is still unclear but the feasibility to activate or repress endogenous gene expression with small RNA molecules has already been demonstrated in vitro and in vivo. In traditional gene therapy non-mutated or otherwise useful genes are inserted into patient's cells to treat a disease. In epigenetherapy the action of small RNAs is utilized by delivering only the small RNAs to patient's cells where they then regulate gene expression by epigenetic mechanisms. This method could be widely useful not only for basic research but also for clinical applications of small RNAs. ©2011 by Walter de Gruyter Berlin Boston |
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Small RNAs have been shown to regulate gene transcription by interacting with the promoter region and modifying the histone code. The exact mechanism of function is still unclear but the feasibility to activate or repress endogenous gene expression with small RNA molecules has already been demonstrated in vitro and in vivo. In traditional gene therapy non-mutated or otherwise useful genes are inserted into patient's cells to treat a disease. In epigenetherapy the action of small RNAs is utilized by delivering only the small RNAs to patient's cells where they then regulate gene expression by epigenetic mechanisms. This method could be widely useful not only for basic research but also for clinical applications of small RNAs. ©2011 by Walter de Gruyter Berlin Boston |
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