Investigation of the influence of blood flow rate on large vessel cooling in hepatic radiofrequency ablation / Untersuchung des Einflusses der Blutflussgeschwindigkeit auf die Gefäßkühlung bei der Radiofrequenzablation von Lebertumoren
Radiofrequency (RF) ablation using high-frequency current has become an important treatment method for patients with non-resectable liver tumors. Tumor recurrence is associated with tissue cooling in the proximity of large blood vessels. This study investigated the influence of blood flow rate on ti...
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Walter de Gruyter ; 2006 |
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©2006 by Walter de Gruyter Berlin New York |
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10 |
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Walter de Gruyter Online Zeitschriften |
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Enthalten in: Biomedical engineering - Berlin [u.a.] : de Gruyter, 1998, 51(2006), 5/6 vom: 07. Dez., Seite 337-346 |
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volume:51 ; year:2006 ; number:5/6 ; day:07 ; month:12 ; pages:337-346 ; extent:10 |
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| DOI / URN: |
10.1515/BMT.2006.067 |
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NLEJ246620943 |
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| 245 | 1 | 0 | |a Investigation of the influence of blood flow rate on large vessel cooling in hepatic radiofrequency ablation / Untersuchung des Einflusses der Blutflussgeschwindigkeit auf die Gefäßkühlung bei der Radiofrequenzablation von Lebertumoren |
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| 520 | |a Radiofrequency (RF) ablation using high-frequency current has become an important treatment method for patients with non-resectable liver tumors. Tumor recurrence is associated with tissue cooling in the proximity of large blood vessels. This study investigated the influence of blood flow rate on tissue temperature and lesion size during monopolar RF ablation at a distance of 10 mm from single 4- and 6-mm vessels using two different approaches: 1) an ex vivo blood perfusion circuit including an artificial vessel inserted into porcine liver tissue was developed; and 2) a finite element method (FEM) model was created using a novel simplified modeling technique for large blood vessels. Blood temperatures at the inflow/outflow of the vessel and tissue temperatures at 10 and 20 mm from the electrode tip were measured in the ex vivo set-up. Tissue temperature, blood temperature and lesion size were analyzed under physiological, increased and reduced blood-flow conditions. The results show that changes in blood flow rate in large vessels do not significantly affect tissue temperature and lesion size far away from the vessel. Monopolar ablation could not produce lesions surrounding the vessel due to the strong heat-sink effect. Simulated tissue temperatures correlated well with ex vivo measurements, supporting the FEM model. | ||
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10.1515/BMT.2006.067 doi artikel_Grundlieferung.pp (DE-627)NLEJ246620943 DE-627 ger DE-627 rakwb Investigation of the influence of blood flow rate on large vessel cooling in hepatic radiofrequency ablation / Untersuchung des Einflusses der Blutflussgeschwindigkeit auf die Gefäßkühlung bei der Radiofrequenzablation von Lebertumoren Walter de Gruyter 2006 10 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier ©2006 by Walter de Gruyter Berlin New York Radiofrequency (RF) ablation using high-frequency current has become an important treatment method for patients with non-resectable liver tumors. Tumor recurrence is associated with tissue cooling in the proximity of large blood vessels. This study investigated the influence of blood flow rate on tissue temperature and lesion size during monopolar RF ablation at a distance of 10 mm from single 4- and 6-mm vessels using two different approaches: 1) an ex vivo blood perfusion circuit including an artificial vessel inserted into porcine liver tissue was developed; and 2) a finite element method (FEM) model was created using a novel simplified modeling technique for large blood vessels. Blood temperatures at the inflow/outflow of the vessel and tissue temperatures at 10 and 20 mm from the electrode tip were measured in the ex vivo set-up. Tissue temperature, blood temperature and lesion size were analyzed under physiological, increased and reduced blood-flow conditions. The results show that changes in blood flow rate in large vessels do not significantly affect tissue temperature and lesion size far away from the vessel. Monopolar ablation could not produce lesions surrounding the vessel due to the strong heat-sink effect. Simulated tissue temperatures correlated well with ex vivo measurements, supporting the FEM model. Walter de Gruyter Online Zeitschriften blood flow rate blood vessel finite element model liver tumors radiofrequency ablation Blutflussgeschwindigkeit Blutgefäß Finite-Elemente-Modell Lebertumoren Radiofrequenzablation Welp, Christoph oth Siebers, Stefan oth Ermert, Helmut oth Werner, Jürgen oth Enthalten in Biomedical engineering Berlin [u.a.] : de Gruyter, 1998 51(2006), 5/6 vom: 07. Dez., Seite 337-346 (DE-627)NLEJ24823515X (DE-600)2234381-7 1862-278X nnns volume:51 year:2006 number:5/6 day:07 month:12 pages:337-346 extent:10 https://doi.org/10.1515/BMT.2006.067 Deutschlandweit zugänglich GBV_USEFLAG_U ZDB-1-DGR GBV_NL_ARTICLE AR 51 2006 5/6 07 12 337-346 10 |
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10.1515/BMT.2006.067 doi artikel_Grundlieferung.pp (DE-627)NLEJ246620943 DE-627 ger DE-627 rakwb Investigation of the influence of blood flow rate on large vessel cooling in hepatic radiofrequency ablation / Untersuchung des Einflusses der Blutflussgeschwindigkeit auf die Gefäßkühlung bei der Radiofrequenzablation von Lebertumoren Walter de Gruyter 2006 10 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier ©2006 by Walter de Gruyter Berlin New York Radiofrequency (RF) ablation using high-frequency current has become an important treatment method for patients with non-resectable liver tumors. Tumor recurrence is associated with tissue cooling in the proximity of large blood vessels. This study investigated the influence of blood flow rate on tissue temperature and lesion size during monopolar RF ablation at a distance of 10 mm from single 4- and 6-mm vessels using two different approaches: 1) an ex vivo blood perfusion circuit including an artificial vessel inserted into porcine liver tissue was developed; and 2) a finite element method (FEM) model was created using a novel simplified modeling technique for large blood vessels. Blood temperatures at the inflow/outflow of the vessel and tissue temperatures at 10 and 20 mm from the electrode tip were measured in the ex vivo set-up. Tissue temperature, blood temperature and lesion size were analyzed under physiological, increased and reduced blood-flow conditions. The results show that changes in blood flow rate in large vessels do not significantly affect tissue temperature and lesion size far away from the vessel. Monopolar ablation could not produce lesions surrounding the vessel due to the strong heat-sink effect. Simulated tissue temperatures correlated well with ex vivo measurements, supporting the FEM model. Walter de Gruyter Online Zeitschriften blood flow rate blood vessel finite element model liver tumors radiofrequency ablation Blutflussgeschwindigkeit Blutgefäß Finite-Elemente-Modell Lebertumoren Radiofrequenzablation Welp, Christoph oth Siebers, Stefan oth Ermert, Helmut oth Werner, Jürgen oth Enthalten in Biomedical engineering Berlin [u.a.] : de Gruyter, 1998 51(2006), 5/6 vom: 07. Dez., Seite 337-346 (DE-627)NLEJ24823515X (DE-600)2234381-7 1862-278X nnns volume:51 year:2006 number:5/6 day:07 month:12 pages:337-346 extent:10 https://doi.org/10.1515/BMT.2006.067 Deutschlandweit zugänglich GBV_USEFLAG_U ZDB-1-DGR GBV_NL_ARTICLE AR 51 2006 5/6 07 12 337-346 10 |
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10.1515/BMT.2006.067 doi artikel_Grundlieferung.pp (DE-627)NLEJ246620943 DE-627 ger DE-627 rakwb Investigation of the influence of blood flow rate on large vessel cooling in hepatic radiofrequency ablation / Untersuchung des Einflusses der Blutflussgeschwindigkeit auf die Gefäßkühlung bei der Radiofrequenzablation von Lebertumoren Walter de Gruyter 2006 10 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier ©2006 by Walter de Gruyter Berlin New York Radiofrequency (RF) ablation using high-frequency current has become an important treatment method for patients with non-resectable liver tumors. Tumor recurrence is associated with tissue cooling in the proximity of large blood vessels. This study investigated the influence of blood flow rate on tissue temperature and lesion size during monopolar RF ablation at a distance of 10 mm from single 4- and 6-mm vessels using two different approaches: 1) an ex vivo blood perfusion circuit including an artificial vessel inserted into porcine liver tissue was developed; and 2) a finite element method (FEM) model was created using a novel simplified modeling technique for large blood vessels. Blood temperatures at the inflow/outflow of the vessel and tissue temperatures at 10 and 20 mm from the electrode tip were measured in the ex vivo set-up. Tissue temperature, blood temperature and lesion size were analyzed under physiological, increased and reduced blood-flow conditions. The results show that changes in blood flow rate in large vessels do not significantly affect tissue temperature and lesion size far away from the vessel. Monopolar ablation could not produce lesions surrounding the vessel due to the strong heat-sink effect. Simulated tissue temperatures correlated well with ex vivo measurements, supporting the FEM model. Walter de Gruyter Online Zeitschriften blood flow rate blood vessel finite element model liver tumors radiofrequency ablation Blutflussgeschwindigkeit Blutgefäß Finite-Elemente-Modell Lebertumoren Radiofrequenzablation Welp, Christoph oth Siebers, Stefan oth Ermert, Helmut oth Werner, Jürgen oth Enthalten in Biomedical engineering Berlin [u.a.] : de Gruyter, 1998 51(2006), 5/6 vom: 07. Dez., Seite 337-346 (DE-627)NLEJ24823515X (DE-600)2234381-7 1862-278X nnns volume:51 year:2006 number:5/6 day:07 month:12 pages:337-346 extent:10 https://doi.org/10.1515/BMT.2006.067 Deutschlandweit zugänglich GBV_USEFLAG_U ZDB-1-DGR GBV_NL_ARTICLE AR 51 2006 5/6 07 12 337-346 10 |
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10.1515/BMT.2006.067 doi artikel_Grundlieferung.pp (DE-627)NLEJ246620943 DE-627 ger DE-627 rakwb Investigation of the influence of blood flow rate on large vessel cooling in hepatic radiofrequency ablation / Untersuchung des Einflusses der Blutflussgeschwindigkeit auf die Gefäßkühlung bei der Radiofrequenzablation von Lebertumoren Walter de Gruyter 2006 10 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier ©2006 by Walter de Gruyter Berlin New York Radiofrequency (RF) ablation using high-frequency current has become an important treatment method for patients with non-resectable liver tumors. Tumor recurrence is associated with tissue cooling in the proximity of large blood vessels. This study investigated the influence of blood flow rate on tissue temperature and lesion size during monopolar RF ablation at a distance of 10 mm from single 4- and 6-mm vessels using two different approaches: 1) an ex vivo blood perfusion circuit including an artificial vessel inserted into porcine liver tissue was developed; and 2) a finite element method (FEM) model was created using a novel simplified modeling technique for large blood vessels. Blood temperatures at the inflow/outflow of the vessel and tissue temperatures at 10 and 20 mm from the electrode tip were measured in the ex vivo set-up. Tissue temperature, blood temperature and lesion size were analyzed under physiological, increased and reduced blood-flow conditions. The results show that changes in blood flow rate in large vessels do not significantly affect tissue temperature and lesion size far away from the vessel. Monopolar ablation could not produce lesions surrounding the vessel due to the strong heat-sink effect. Simulated tissue temperatures correlated well with ex vivo measurements, supporting the FEM model. Walter de Gruyter Online Zeitschriften blood flow rate blood vessel finite element model liver tumors radiofrequency ablation Blutflussgeschwindigkeit Blutgefäß Finite-Elemente-Modell Lebertumoren Radiofrequenzablation Welp, Christoph oth Siebers, Stefan oth Ermert, Helmut oth Werner, Jürgen oth Enthalten in Biomedical engineering Berlin [u.a.] : de Gruyter, 1998 51(2006), 5/6 vom: 07. Dez., Seite 337-346 (DE-627)NLEJ24823515X (DE-600)2234381-7 1862-278X nnns volume:51 year:2006 number:5/6 day:07 month:12 pages:337-346 extent:10 https://doi.org/10.1515/BMT.2006.067 Deutschlandweit zugänglich GBV_USEFLAG_U ZDB-1-DGR GBV_NL_ARTICLE AR 51 2006 5/6 07 12 337-346 10 |
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10.1515/BMT.2006.067 doi artikel_Grundlieferung.pp (DE-627)NLEJ246620943 DE-627 ger DE-627 rakwb Investigation of the influence of blood flow rate on large vessel cooling in hepatic radiofrequency ablation / Untersuchung des Einflusses der Blutflussgeschwindigkeit auf die Gefäßkühlung bei der Radiofrequenzablation von Lebertumoren Walter de Gruyter 2006 10 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier ©2006 by Walter de Gruyter Berlin New York Radiofrequency (RF) ablation using high-frequency current has become an important treatment method for patients with non-resectable liver tumors. Tumor recurrence is associated with tissue cooling in the proximity of large blood vessels. This study investigated the influence of blood flow rate on tissue temperature and lesion size during monopolar RF ablation at a distance of 10 mm from single 4- and 6-mm vessels using two different approaches: 1) an ex vivo blood perfusion circuit including an artificial vessel inserted into porcine liver tissue was developed; and 2) a finite element method (FEM) model was created using a novel simplified modeling technique for large blood vessels. Blood temperatures at the inflow/outflow of the vessel and tissue temperatures at 10 and 20 mm from the electrode tip were measured in the ex vivo set-up. Tissue temperature, blood temperature and lesion size were analyzed under physiological, increased and reduced blood-flow conditions. The results show that changes in blood flow rate in large vessels do not significantly affect tissue temperature and lesion size far away from the vessel. Monopolar ablation could not produce lesions surrounding the vessel due to the strong heat-sink effect. Simulated tissue temperatures correlated well with ex vivo measurements, supporting the FEM model. Walter de Gruyter Online Zeitschriften blood flow rate blood vessel finite element model liver tumors radiofrequency ablation Blutflussgeschwindigkeit Blutgefäß Finite-Elemente-Modell Lebertumoren Radiofrequenzablation Welp, Christoph oth Siebers, Stefan oth Ermert, Helmut oth Werner, Jürgen oth Enthalten in Biomedical engineering Berlin [u.a.] : de Gruyter, 1998 51(2006), 5/6 vom: 07. Dez., Seite 337-346 (DE-627)NLEJ24823515X (DE-600)2234381-7 1862-278X nnns volume:51 year:2006 number:5/6 day:07 month:12 pages:337-346 extent:10 https://doi.org/10.1515/BMT.2006.067 Deutschlandweit zugänglich GBV_USEFLAG_U ZDB-1-DGR GBV_NL_ARTICLE AR 51 2006 5/6 07 12 337-346 10 |
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Investigation of the influence of blood flow rate on large vessel cooling in hepatic radiofrequency ablation / Untersuchung des Einflusses der Blutflussgeschwindigkeit auf die Gefäßkühlung bei der Radiofrequenzablation von Lebertumoren blood flow rate blood vessel finite element model liver tumors radiofrequency ablation Blutflussgeschwindigkeit Blutgefäß Finite-Elemente-Modell Lebertumoren Radiofrequenzablation |
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Investigation of the influence of blood flow rate on large vessel cooling in hepatic radiofrequency ablation / Untersuchung des Einflusses der Blutflussgeschwindigkeit auf die Gefäßkühlung bei der Radiofrequenzablation von Lebertumoren |
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(DE-627)NLEJ246620943 |
| title_full |
Investigation of the influence of blood flow rate on large vessel cooling in hepatic radiofrequency ablation / Untersuchung des Einflusses der Blutflussgeschwindigkeit auf die Gefäßkühlung bei der Radiofrequenzablation von Lebertumoren |
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Biomedical engineering |
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Biomedical engineering |
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2006 |
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337 |
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51 |
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10 |
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Elektronische Aufsätze |
| doi_str_mv |
10.1515/BMT.2006.067 |
| title_sort |
investigation of the influence of blood flow rate on large vessel cooling in hepatic radiofrequency ablation / untersuchung des einflusses der blutflussgeschwindigkeit auf die gefäßkühlung bei der radiofrequenzablation von lebertumoren |
| title_auth |
Investigation of the influence of blood flow rate on large vessel cooling in hepatic radiofrequency ablation / Untersuchung des Einflusses der Blutflussgeschwindigkeit auf die Gefäßkühlung bei der Radiofrequenzablation von Lebertumoren |
| abstract |
Radiofrequency (RF) ablation using high-frequency current has become an important treatment method for patients with non-resectable liver tumors. Tumor recurrence is associated with tissue cooling in the proximity of large blood vessels. This study investigated the influence of blood flow rate on tissue temperature and lesion size during monopolar RF ablation at a distance of 10 mm from single 4- and 6-mm vessels using two different approaches: 1) an ex vivo blood perfusion circuit including an artificial vessel inserted into porcine liver tissue was developed; and 2) a finite element method (FEM) model was created using a novel simplified modeling technique for large blood vessels. Blood temperatures at the inflow/outflow of the vessel and tissue temperatures at 10 and 20 mm from the electrode tip were measured in the ex vivo set-up. Tissue temperature, blood temperature and lesion size were analyzed under physiological, increased and reduced blood-flow conditions. The results show that changes in blood flow rate in large vessels do not significantly affect tissue temperature and lesion size far away from the vessel. Monopolar ablation could not produce lesions surrounding the vessel due to the strong heat-sink effect. Simulated tissue temperatures correlated well with ex vivo measurements, supporting the FEM model. ©2006 by Walter de Gruyter Berlin New York |
| abstractGer |
Radiofrequency (RF) ablation using high-frequency current has become an important treatment method for patients with non-resectable liver tumors. Tumor recurrence is associated with tissue cooling in the proximity of large blood vessels. This study investigated the influence of blood flow rate on tissue temperature and lesion size during monopolar RF ablation at a distance of 10 mm from single 4- and 6-mm vessels using two different approaches: 1) an ex vivo blood perfusion circuit including an artificial vessel inserted into porcine liver tissue was developed; and 2) a finite element method (FEM) model was created using a novel simplified modeling technique for large blood vessels. Blood temperatures at the inflow/outflow of the vessel and tissue temperatures at 10 and 20 mm from the electrode tip were measured in the ex vivo set-up. Tissue temperature, blood temperature and lesion size were analyzed under physiological, increased and reduced blood-flow conditions. The results show that changes in blood flow rate in large vessels do not significantly affect tissue temperature and lesion size far away from the vessel. Monopolar ablation could not produce lesions surrounding the vessel due to the strong heat-sink effect. Simulated tissue temperatures correlated well with ex vivo measurements, supporting the FEM model. ©2006 by Walter de Gruyter Berlin New York |
| abstract_unstemmed |
Radiofrequency (RF) ablation using high-frequency current has become an important treatment method for patients with non-resectable liver tumors. Tumor recurrence is associated with tissue cooling in the proximity of large blood vessels. This study investigated the influence of blood flow rate on tissue temperature and lesion size during monopolar RF ablation at a distance of 10 mm from single 4- and 6-mm vessels using two different approaches: 1) an ex vivo blood perfusion circuit including an artificial vessel inserted into porcine liver tissue was developed; and 2) a finite element method (FEM) model was created using a novel simplified modeling technique for large blood vessels. Blood temperatures at the inflow/outflow of the vessel and tissue temperatures at 10 and 20 mm from the electrode tip were measured in the ex vivo set-up. Tissue temperature, blood temperature and lesion size were analyzed under physiological, increased and reduced blood-flow conditions. The results show that changes in blood flow rate in large vessels do not significantly affect tissue temperature and lesion size far away from the vessel. Monopolar ablation could not produce lesions surrounding the vessel due to the strong heat-sink effect. Simulated tissue temperatures correlated well with ex vivo measurements, supporting the FEM model. ©2006 by Walter de Gruyter Berlin New York |
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| title_short |
Investigation of the influence of blood flow rate on large vessel cooling in hepatic radiofrequency ablation / Untersuchung des Einflusses der Blutflussgeschwindigkeit auf die Gefäßkühlung bei der Radiofrequenzablation von Lebertumoren |
| url |
https://doi.org/10.1515/BMT.2006.067 |
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| author2 |
Welp, Christoph Siebers, Stefan Ermert, Helmut Werner, Jürgen |
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Welp, Christoph Siebers, Stefan Ermert, Helmut Werner, Jürgen |
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2024-07-06T08:55:07.233Z |
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