Formate: an essential metabolite, a biomarker, or more?
Plasma and urinary formate concentrations were recently found to be elevated during vitamin B12 and folate deficiencies. It was proposed that formate may be a valuable biomarker of impaired one-carbon metabolism. Formate is an essential intermediary metabolite in folate-mediated one-carbon metabolis...
Ausführliche Beschreibung
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De Gruyter ; 2012 |
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8 |
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Walter de Gruyter Online Zeitschriften |
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Enthalten in: Clinical chemistry and laboratory medicine - Berlin [u.a.] : De Gruyter, 1998, 51(2012), 3 vom: 14. Dez., Seite 571-578 |
Übergeordnetes Werk: |
volume:51 ; year:2012 ; number:3 ; day:14 ; month:12 ; pages:571-578 ; extent:8 |
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DOI / URN: |
10.1515/cclm-2012-0552 |
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NLEJ246694483 |
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10.1515/cclm-2012-0552 doi artikel_Grundlieferung.pp (DE-627)NLEJ246694483 DE-627 ger DE-627 rakwb Formate: an essential metabolite, a biomarker, or more? De Gruyter 2012 8 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Plasma and urinary formate concentrations were recently found to be elevated during vitamin B12 and folate deficiencies. It was proposed that formate may be a valuable biomarker of impaired one-carbon metabolism. Formate is an essential intermediary metabolite in folate-mediated one-carbon metabolism and, despite its importance, our knowledge of its metabolism is limited. Formate can be produced from several substrates (e.g., methanol, branched chain fatty acids, amino acids), some reactions being folate-dependent while others are not. Formate removal proceeds via two pathways; the major one being folate-dependent. Formate is a potentially toxic molecule and we suggest that formate may play a role in some of the pathologies associated with defective one-carbon metabolism. Walter de Gruyter Online Zeitschriften folic acid formic acid vitamin B2 vitamin B6 vitamin B12 Lamarre, Simon G. oth Morrow, Gregory oth Macmillan, Luke oth Brosnan, Margaret E. oth Brosnan, John T. oth Enthalten in Clinical chemistry and laboratory medicine Berlin [u.a.] : De Gruyter, 1998 51(2012), 3 vom: 14. Dez., Seite 571-578 (DE-627)NLEJ248235222 (DE-600)1492732-9 1437-4331 nnns volume:51 year:2012 number:3 day:14 month:12 pages:571-578 extent:8 https://doi.org/10.1515/cclm-2012-0552 Deutschlandweit zugänglich GBV_USEFLAG_U ZDB-1-DGR GBV_NL_ARTICLE AR 51 2012 3 14 12 571-578 8 |
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10.1515/cclm-2012-0552 doi artikel_Grundlieferung.pp (DE-627)NLEJ246694483 DE-627 ger DE-627 rakwb Formate: an essential metabolite, a biomarker, or more? De Gruyter 2012 8 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Plasma and urinary formate concentrations were recently found to be elevated during vitamin B12 and folate deficiencies. It was proposed that formate may be a valuable biomarker of impaired one-carbon metabolism. Formate is an essential intermediary metabolite in folate-mediated one-carbon metabolism and, despite its importance, our knowledge of its metabolism is limited. Formate can be produced from several substrates (e.g., methanol, branched chain fatty acids, amino acids), some reactions being folate-dependent while others are not. Formate removal proceeds via two pathways; the major one being folate-dependent. Formate is a potentially toxic molecule and we suggest that formate may play a role in some of the pathologies associated with defective one-carbon metabolism. Walter de Gruyter Online Zeitschriften folic acid formic acid vitamin B2 vitamin B6 vitamin B12 Lamarre, Simon G. oth Morrow, Gregory oth Macmillan, Luke oth Brosnan, Margaret E. oth Brosnan, John T. oth Enthalten in Clinical chemistry and laboratory medicine Berlin [u.a.] : De Gruyter, 1998 51(2012), 3 vom: 14. Dez., Seite 571-578 (DE-627)NLEJ248235222 (DE-600)1492732-9 1437-4331 nnns volume:51 year:2012 number:3 day:14 month:12 pages:571-578 extent:8 https://doi.org/10.1515/cclm-2012-0552 Deutschlandweit zugänglich GBV_USEFLAG_U ZDB-1-DGR GBV_NL_ARTICLE AR 51 2012 3 14 12 571-578 8 |
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10.1515/cclm-2012-0552 doi artikel_Grundlieferung.pp (DE-627)NLEJ246694483 DE-627 ger DE-627 rakwb Formate: an essential metabolite, a biomarker, or more? De Gruyter 2012 8 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Plasma and urinary formate concentrations were recently found to be elevated during vitamin B12 and folate deficiencies. It was proposed that formate may be a valuable biomarker of impaired one-carbon metabolism. Formate is an essential intermediary metabolite in folate-mediated one-carbon metabolism and, despite its importance, our knowledge of its metabolism is limited. Formate can be produced from several substrates (e.g., methanol, branched chain fatty acids, amino acids), some reactions being folate-dependent while others are not. Formate removal proceeds via two pathways; the major one being folate-dependent. Formate is a potentially toxic molecule and we suggest that formate may play a role in some of the pathologies associated with defective one-carbon metabolism. Walter de Gruyter Online Zeitschriften folic acid formic acid vitamin B2 vitamin B6 vitamin B12 Lamarre, Simon G. oth Morrow, Gregory oth Macmillan, Luke oth Brosnan, Margaret E. oth Brosnan, John T. oth Enthalten in Clinical chemistry and laboratory medicine Berlin [u.a.] : De Gruyter, 1998 51(2012), 3 vom: 14. Dez., Seite 571-578 (DE-627)NLEJ248235222 (DE-600)1492732-9 1437-4331 nnns volume:51 year:2012 number:3 day:14 month:12 pages:571-578 extent:8 https://doi.org/10.1515/cclm-2012-0552 Deutschlandweit zugänglich GBV_USEFLAG_U ZDB-1-DGR GBV_NL_ARTICLE AR 51 2012 3 14 12 571-578 8 |
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Plasma and urinary formate concentrations were recently found to be elevated during vitamin B12 and folate deficiencies. It was proposed that formate may be a valuable biomarker of impaired one-carbon metabolism. Formate is an essential intermediary metabolite in folate-mediated one-carbon metabolism and, despite its importance, our knowledge of its metabolism is limited. Formate can be produced from several substrates (e.g., methanol, branched chain fatty acids, amino acids), some reactions being folate-dependent while others are not. Formate removal proceeds via two pathways; the major one being folate-dependent. Formate is a potentially toxic molecule and we suggest that formate may play a role in some of the pathologies associated with defective one-carbon metabolism. |
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Plasma and urinary formate concentrations were recently found to be elevated during vitamin B12 and folate deficiencies. It was proposed that formate may be a valuable biomarker of impaired one-carbon metabolism. Formate is an essential intermediary metabolite in folate-mediated one-carbon metabolism and, despite its importance, our knowledge of its metabolism is limited. Formate can be produced from several substrates (e.g., methanol, branched chain fatty acids, amino acids), some reactions being folate-dependent while others are not. Formate removal proceeds via two pathways; the major one being folate-dependent. Formate is a potentially toxic molecule and we suggest that formate may play a role in some of the pathologies associated with defective one-carbon metabolism. |
abstract_unstemmed |
Plasma and urinary formate concentrations were recently found to be elevated during vitamin B12 and folate deficiencies. It was proposed that formate may be a valuable biomarker of impaired one-carbon metabolism. Formate is an essential intermediary metabolite in folate-mediated one-carbon metabolism and, despite its importance, our knowledge of its metabolism is limited. Formate can be produced from several substrates (e.g., methanol, branched chain fatty acids, amino acids), some reactions being folate-dependent while others are not. Formate removal proceeds via two pathways; the major one being folate-dependent. Formate is a potentially toxic molecule and we suggest that formate may play a role in some of the pathologies associated with defective one-carbon metabolism. |
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<?xml version="1.0" encoding="UTF-8"?><collection xmlns="http://www.loc.gov/MARC21/slim"><record><leader>01000caa a22002652 4500</leader><controlfield tag="001">NLEJ246694483</controlfield><controlfield tag="003">DE-627</controlfield><controlfield tag="005">20230505195040.0</controlfield><controlfield tag="007">cr uuu---uuuuu</controlfield><controlfield tag="008">220814s2012 xx |||||o 00| ||und c</controlfield><datafield tag="024" ind1="7" ind2=" "><subfield code="a">10.1515/cclm-2012-0552</subfield><subfield code="2">doi</subfield></datafield><datafield tag="028" ind1="5" ind2="2"><subfield code="a">artikel_Grundlieferung.pp</subfield></datafield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(DE-627)NLEJ246694483</subfield></datafield><datafield tag="040" ind1=" " ind2=" "><subfield code="a">DE-627</subfield><subfield code="b">ger</subfield><subfield code="c">DE-627</subfield><subfield code="e">rakwb</subfield></datafield><datafield tag="245" ind1="1" ind2="0"><subfield code="a">Formate: an essential metabolite, a biomarker, or more?</subfield></datafield><datafield tag="264" ind1=" " ind2="1"><subfield code="b">De Gruyter</subfield><subfield code="c">2012</subfield></datafield><datafield tag="300" ind1=" " ind2=" "><subfield code="a">8</subfield></datafield><datafield tag="336" ind1=" " ind2=" "><subfield code="a">Text</subfield><subfield code="b">txt</subfield><subfield code="2">rdacontent</subfield></datafield><datafield tag="337" ind1=" " ind2=" "><subfield code="a">Computermedien</subfield><subfield code="b">c</subfield><subfield code="2">rdamedia</subfield></datafield><datafield tag="338" ind1=" " ind2=" "><subfield code="a">Online-Ressource</subfield><subfield code="b">cr</subfield><subfield code="2">rdacarrier</subfield></datafield><datafield tag="520" ind1=" " ind2=" "><subfield code="a">Plasma and urinary formate concentrations were recently found to be elevated during vitamin B12 and folate deficiencies. 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Formate is a potentially toxic molecule and we suggest that formate may play a role in some of the pathologies associated with defective one-carbon metabolism.</subfield></datafield><datafield tag="533" ind1=" " ind2=" "><subfield code="f">Walter de Gruyter Online Zeitschriften</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">folic acid</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">formic acid</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">vitamin B2</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">vitamin B6</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">vitamin B12</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Lamarre, Simon G.</subfield><subfield code="4">oth</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Morrow, Gregory</subfield><subfield code="4">oth</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Macmillan, Luke</subfield><subfield code="4">oth</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Brosnan, Margaret E.</subfield><subfield code="4">oth</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Brosnan, John T.</subfield><subfield code="4">oth</subfield></datafield><datafield tag="773" ind1="0" ind2="8"><subfield code="i">Enthalten in</subfield><subfield code="t">Clinical chemistry and laboratory medicine</subfield><subfield code="d">Berlin [u.a.] : De Gruyter, 1998</subfield><subfield code="g">51(2012), 3 vom: 14. Dez., Seite 571-578</subfield><subfield code="w">(DE-627)NLEJ248235222</subfield><subfield code="w">(DE-600)1492732-9</subfield><subfield code="x">1437-4331</subfield><subfield code="7">nnns</subfield></datafield><datafield tag="773" ind1="1" ind2="8"><subfield code="g">volume:51</subfield><subfield code="g">year:2012</subfield><subfield code="g">number:3</subfield><subfield code="g">day:14</subfield><subfield code="g">month:12</subfield><subfield code="g">pages:571-578</subfield><subfield code="g">extent:8</subfield></datafield><datafield tag="856" ind1="4" ind2="0"><subfield code="u">https://doi.org/10.1515/cclm-2012-0552</subfield><subfield code="z">Deutschlandweit zugänglich</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_USEFLAG_U</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">ZDB-1-DGR</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_NL_ARTICLE</subfield></datafield><datafield tag="951" ind1=" " ind2=" "><subfield code="a">AR</subfield></datafield><datafield tag="952" ind1=" " ind2=" "><subfield code="d">51</subfield><subfield code="j">2012</subfield><subfield code="e">3</subfield><subfield code="b">14</subfield><subfield code="c">12</subfield><subfield code="h">571-578</subfield><subfield code="g">8</subfield></datafield></record></collection>
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