Database Analysis and Gene Discovery in Pharmacogenetics
The global genome research effort has resulted in thecreation of extensive DNA and protein sequence databasesthat are a valuable resource for the identificationof new genes and polymorphic variants of enzymes ofpharmacogenetic interest. Previously undescribedmembers of gene families with novel funct...
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E-Artikel |
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| Erschienen: |
Walter de Gruyter ; 2005 |
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| Anmerkung: |
Copyright © 2000 by Walter de Gruyter GmbH & Co. KG |
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| Umfang: |
5 |
| Reproduktion: |
Walter de Gruyter Online Zeitschriften |
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| Übergeordnetes Werk: |
In: 38(2005), 9 vom: 01. Juni, Seite 863-867 volume:38 ; year:2005 ; number:9 ; day:01 ; month:06 ; pages:863-867 ; extent:5 |
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| DOI / URN: |
10.1515/CCLM.2000.125 |
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10.1515/CCLM.2000.125 doi artikel_Grundlieferung.pp (DE-627)NLEJ24670229X DE-627 ger DE-627 rakwb Database Analysis and Gene Discovery in Pharmacogenetics Walter de Gruyter 2005 5 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Copyright © 2000 by Walter de Gruyter GmbH & Co. KG The global genome research effort has resulted in thecreation of extensive DNA and protein sequence databasesthat are a valuable resource for the identificationof new genes and polymorphic variants of enzymes ofpharmacogenetic interest. Previously undescribedmembers of gene families with novel functions andsubstrate specificities can be identified by databasesearching and sequence alignment strategies. Sincethe expressed sequence tag (EST) database containssequences from many individuals, it can be searchedfor evidence of polymorphisms that can significantlyinfluence enzyme function. The different approachesto these forms of analysis are reviewed and illustratedwith examples from the glutathione transferase genefamily. Walter de Gruyter Online Zeitschriften Board, Philip oth Tetlow, Natasha oth Blackburn, Anneke oth Chelvanayagam, Gareth oth In 38(2005), 9 vom: 01. Juni, Seite 863-867 volume:38 year:2005 number:9 day:01 month:06 pages:863-867 extent:5 https://doi.org/10.1515/CCLM.2000.125 Deutschlandweit zugänglich GBV_USEFLAG_U ZDB-1-DGR GBV_NL_ARTICLE AR 38 2005 9 01 06 863-867 5 |
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10.1515/CCLM.2000.125 doi artikel_Grundlieferung.pp (DE-627)NLEJ24670229X DE-627 ger DE-627 rakwb Database Analysis and Gene Discovery in Pharmacogenetics Walter de Gruyter 2005 5 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Copyright © 2000 by Walter de Gruyter GmbH & Co. KG The global genome research effort has resulted in thecreation of extensive DNA and protein sequence databasesthat are a valuable resource for the identificationof new genes and polymorphic variants of enzymes ofpharmacogenetic interest. Previously undescribedmembers of gene families with novel functions andsubstrate specificities can be identified by databasesearching and sequence alignment strategies. Sincethe expressed sequence tag (EST) database containssequences from many individuals, it can be searchedfor evidence of polymorphisms that can significantlyinfluence enzyme function. The different approachesto these forms of analysis are reviewed and illustratedwith examples from the glutathione transferase genefamily. Walter de Gruyter Online Zeitschriften Board, Philip oth Tetlow, Natasha oth Blackburn, Anneke oth Chelvanayagam, Gareth oth In 38(2005), 9 vom: 01. Juni, Seite 863-867 volume:38 year:2005 number:9 day:01 month:06 pages:863-867 extent:5 https://doi.org/10.1515/CCLM.2000.125 Deutschlandweit zugänglich GBV_USEFLAG_U ZDB-1-DGR GBV_NL_ARTICLE AR 38 2005 9 01 06 863-867 5 |
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10.1515/CCLM.2000.125 doi artikel_Grundlieferung.pp (DE-627)NLEJ24670229X DE-627 ger DE-627 rakwb Database Analysis and Gene Discovery in Pharmacogenetics Walter de Gruyter 2005 5 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Copyright © 2000 by Walter de Gruyter GmbH & Co. KG The global genome research effort has resulted in thecreation of extensive DNA and protein sequence databasesthat are a valuable resource for the identificationof new genes and polymorphic variants of enzymes ofpharmacogenetic interest. Previously undescribedmembers of gene families with novel functions andsubstrate specificities can be identified by databasesearching and sequence alignment strategies. Sincethe expressed sequence tag (EST) database containssequences from many individuals, it can be searchedfor evidence of polymorphisms that can significantlyinfluence enzyme function. The different approachesto these forms of analysis are reviewed and illustratedwith examples from the glutathione transferase genefamily. Walter de Gruyter Online Zeitschriften Board, Philip oth Tetlow, Natasha oth Blackburn, Anneke oth Chelvanayagam, Gareth oth In 38(2005), 9 vom: 01. Juni, Seite 863-867 volume:38 year:2005 number:9 day:01 month:06 pages:863-867 extent:5 https://doi.org/10.1515/CCLM.2000.125 Deutschlandweit zugänglich GBV_USEFLAG_U ZDB-1-DGR GBV_NL_ARTICLE AR 38 2005 9 01 06 863-867 5 |
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10.1515/CCLM.2000.125 doi artikel_Grundlieferung.pp (DE-627)NLEJ24670229X DE-627 ger DE-627 rakwb Database Analysis and Gene Discovery in Pharmacogenetics Walter de Gruyter 2005 5 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Copyright © 2000 by Walter de Gruyter GmbH & Co. KG The global genome research effort has resulted in thecreation of extensive DNA and protein sequence databasesthat are a valuable resource for the identificationof new genes and polymorphic variants of enzymes ofpharmacogenetic interest. Previously undescribedmembers of gene families with novel functions andsubstrate specificities can be identified by databasesearching and sequence alignment strategies. Sincethe expressed sequence tag (EST) database containssequences from many individuals, it can be searchedfor evidence of polymorphisms that can significantlyinfluence enzyme function. The different approachesto these forms of analysis are reviewed and illustratedwith examples from the glutathione transferase genefamily. Walter de Gruyter Online Zeitschriften Board, Philip oth Tetlow, Natasha oth Blackburn, Anneke oth Chelvanayagam, Gareth oth In 38(2005), 9 vom: 01. Juni, Seite 863-867 volume:38 year:2005 number:9 day:01 month:06 pages:863-867 extent:5 https://doi.org/10.1515/CCLM.2000.125 Deutschlandweit zugänglich GBV_USEFLAG_U ZDB-1-DGR GBV_NL_ARTICLE AR 38 2005 9 01 06 863-867 5 |
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10.1515/CCLM.2000.125 doi artikel_Grundlieferung.pp (DE-627)NLEJ24670229X DE-627 ger DE-627 rakwb Database Analysis and Gene Discovery in Pharmacogenetics Walter de Gruyter 2005 5 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Copyright © 2000 by Walter de Gruyter GmbH & Co. KG The global genome research effort has resulted in thecreation of extensive DNA and protein sequence databasesthat are a valuable resource for the identificationof new genes and polymorphic variants of enzymes ofpharmacogenetic interest. Previously undescribedmembers of gene families with novel functions andsubstrate specificities can be identified by databasesearching and sequence alignment strategies. Sincethe expressed sequence tag (EST) database containssequences from many individuals, it can be searchedfor evidence of polymorphisms that can significantlyinfluence enzyme function. The different approachesto these forms of analysis are reviewed and illustratedwith examples from the glutathione transferase genefamily. Walter de Gruyter Online Zeitschriften Board, Philip oth Tetlow, Natasha oth Blackburn, Anneke oth Chelvanayagam, Gareth oth In 38(2005), 9 vom: 01. Juni, Seite 863-867 volume:38 year:2005 number:9 day:01 month:06 pages:863-867 extent:5 https://doi.org/10.1515/CCLM.2000.125 Deutschlandweit zugänglich GBV_USEFLAG_U ZDB-1-DGR GBV_NL_ARTICLE AR 38 2005 9 01 06 863-867 5 |
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The global genome research effort has resulted in thecreation of extensive DNA and protein sequence databasesthat are a valuable resource for the identificationof new genes and polymorphic variants of enzymes ofpharmacogenetic interest. Previously undescribedmembers of gene families with novel functions andsubstrate specificities can be identified by databasesearching and sequence alignment strategies. Sincethe expressed sequence tag (EST) database containssequences from many individuals, it can be searchedfor evidence of polymorphisms that can significantlyinfluence enzyme function. The different approachesto these forms of analysis are reviewed and illustratedwith examples from the glutathione transferase genefamily. Copyright © 2000 by Walter de Gruyter GmbH & Co. KG |
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The global genome research effort has resulted in thecreation of extensive DNA and protein sequence databasesthat are a valuable resource for the identificationof new genes and polymorphic variants of enzymes ofpharmacogenetic interest. Previously undescribedmembers of gene families with novel functions andsubstrate specificities can be identified by databasesearching and sequence alignment strategies. Sincethe expressed sequence tag (EST) database containssequences from many individuals, it can be searchedfor evidence of polymorphisms that can significantlyinfluence enzyme function. The different approachesto these forms of analysis are reviewed and illustratedwith examples from the glutathione transferase genefamily. Copyright © 2000 by Walter de Gruyter GmbH & Co. KG |
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The global genome research effort has resulted in thecreation of extensive DNA and protein sequence databasesthat are a valuable resource for the identificationof new genes and polymorphic variants of enzymes ofpharmacogenetic interest. Previously undescribedmembers of gene families with novel functions andsubstrate specificities can be identified by databasesearching and sequence alignment strategies. Sincethe expressed sequence tag (EST) database containssequences from many individuals, it can be searchedfor evidence of polymorphisms that can significantlyinfluence enzyme function. The different approachesto these forms of analysis are reviewed and illustratedwith examples from the glutathione transferase genefamily. Copyright © 2000 by Walter de Gruyter GmbH & Co. KG |
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