Synovial and serum levels of uncarboxylated matrix Gla-protein (ucMGP) in patients with arthritis
Background: Matrix Gla-protein (MGP) is a calcification inhibitor produced by cartilage and vessel walls. Arthritis is defined by inflammation, cartilage and bone destruction/formation and articular calcifications. Our objectives were to evaluate ucMGP levels in synovial fluid (SF) in arthritis pati...
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E-Artikel |
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Walter de Gruyter ; 2011 |
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4 |
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Walter de Gruyter Online Zeitschriften |
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Enthalten in: Clinical chemistry and laboratory medicine - Berlin [u.a.] : De Gruyter, 1998, 50(2011), 1 vom: 17. Sept., Seite 125-128 |
| Übergeordnetes Werk: |
volume:50 ; year:2011 ; number:1 ; day:17 ; month:09 ; pages:125-128 ; extent:4 |
| Links: |
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| DOI / URN: |
10.1515/cclm.2011.713 |
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NLEJ246736151 |
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| 520 | |a Background: Matrix Gla-protein (MGP) is a calcification inhibitor produced by cartilage and vessel walls. Arthritis is defined by inflammation, cartilage and bone destruction/formation and articular calcifications. Our objectives were to evaluate ucMGP levels in synovial fluid (SF) in arthritis patients and to investigate the relationship between local and circulating ucMGP and their association with age and inflammation. Methods: Arthritis patients (n=26) with knee joint effusion and controls (n=30) underwent an ultrasonographic knee examination for articular calcifications assessment. Patients were divided into inflammatory and non-inflammatory groups. ucMGP levels were determined in serum and SF using a competitive ELISA assay. Results: Within the arthritis patients, the inflammatory group had the lowest ucMGP serum levels, and the highest levels of synovial ucMGP. Furthermore, the inflammatory group had significantly (p<0.05) higher RucMGP (synovial ucMGP/serum ucMGP*100) than the non-inflammatory group [36 (17–69) vs. 24 (5–55)], and this parameter positively correlated (r=0.4; p<0.05) with the erythrocyte sedimentation rate (ESR). No correlation was found between age and local or circulating ucMGP in patients and controls. Conclusions: The ucMGP assay can be used for determination of MGP in SF, and combined assessment of ucMGP in serum and SF could potentially serve as a joint inflammatory marker in arthritis patients. | ||
| 533 | |f Walter de Gruyter Online Zeitschriften | ||
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| 700 | 1 | |a Cristea, Victor |4 oth | |
| 700 | 1 | |a Crăciun, Alexandra M. |4 oth | |
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10.1515/cclm.2011.713 doi artikel_Grundlieferung.pp (DE-627)NLEJ246736151 DE-627 ger DE-627 rakwb Synovial and serum levels of uncarboxylated matrix Gla-protein (ucMGP) in patients with arthritis Walter de Gruyter 2011 4 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Background: Matrix Gla-protein (MGP) is a calcification inhibitor produced by cartilage and vessel walls. Arthritis is defined by inflammation, cartilage and bone destruction/formation and articular calcifications. Our objectives were to evaluate ucMGP levels in synovial fluid (SF) in arthritis patients and to investigate the relationship between local and circulating ucMGP and their association with age and inflammation. Methods: Arthritis patients (n=26) with knee joint effusion and controls (n=30) underwent an ultrasonographic knee examination for articular calcifications assessment. Patients were divided into inflammatory and non-inflammatory groups. ucMGP levels were determined in serum and SF using a competitive ELISA assay. Results: Within the arthritis patients, the inflammatory group had the lowest ucMGP serum levels, and the highest levels of synovial ucMGP. Furthermore, the inflammatory group had significantly (p<0.05) higher RucMGP (synovial ucMGP/serum ucMGP*100) than the non-inflammatory group [36 (17–69) vs. 24 (5–55)], and this parameter positively correlated (r=0.4; p<0.05) with the erythrocyte sedimentation rate (ESR). No correlation was found between age and local or circulating ucMGP in patients and controls. Conclusions: The ucMGP assay can be used for determination of MGP in SF, and combined assessment of ucMGP in serum and SF could potentially serve as a joint inflammatory marker in arthritis patients. Walter de Gruyter Online Zeitschriften arthritis articular calcifications inflammation matrix Gla-protein synovial fluid Silaghi, Ciprian N. oth Fodor, Dana oth Cristea, Victor oth Crăciun, Alexandra M. oth Enthalten in Clinical chemistry and laboratory medicine Berlin [u.a.] : De Gruyter, 1998 50(2011), 1 vom: 17. Sept., Seite 125-128 (DE-627)NLEJ248235222 (DE-600)1492732-9 1437-4331 nnns volume:50 year:2011 number:1 day:17 month:09 pages:125-128 extent:4 https://doi.org/10.1515/cclm.2011.713 Deutschlandweit zugänglich GBV_USEFLAG_U ZDB-1-DGR GBV_NL_ARTICLE AR 50 2011 1 17 09 125-128 4 |
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10.1515/cclm.2011.713 doi artikel_Grundlieferung.pp (DE-627)NLEJ246736151 DE-627 ger DE-627 rakwb Synovial and serum levels of uncarboxylated matrix Gla-protein (ucMGP) in patients with arthritis Walter de Gruyter 2011 4 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Background: Matrix Gla-protein (MGP) is a calcification inhibitor produced by cartilage and vessel walls. Arthritis is defined by inflammation, cartilage and bone destruction/formation and articular calcifications. Our objectives were to evaluate ucMGP levels in synovial fluid (SF) in arthritis patients and to investigate the relationship between local and circulating ucMGP and their association with age and inflammation. Methods: Arthritis patients (n=26) with knee joint effusion and controls (n=30) underwent an ultrasonographic knee examination for articular calcifications assessment. Patients were divided into inflammatory and non-inflammatory groups. ucMGP levels were determined in serum and SF using a competitive ELISA assay. Results: Within the arthritis patients, the inflammatory group had the lowest ucMGP serum levels, and the highest levels of synovial ucMGP. Furthermore, the inflammatory group had significantly (p<0.05) higher RucMGP (synovial ucMGP/serum ucMGP*100) than the non-inflammatory group [36 (17–69) vs. 24 (5–55)], and this parameter positively correlated (r=0.4; p<0.05) with the erythrocyte sedimentation rate (ESR). No correlation was found between age and local or circulating ucMGP in patients and controls. Conclusions: The ucMGP assay can be used for determination of MGP in SF, and combined assessment of ucMGP in serum and SF could potentially serve as a joint inflammatory marker in arthritis patients. Walter de Gruyter Online Zeitschriften arthritis articular calcifications inflammation matrix Gla-protein synovial fluid Silaghi, Ciprian N. oth Fodor, Dana oth Cristea, Victor oth Crăciun, Alexandra M. oth Enthalten in Clinical chemistry and laboratory medicine Berlin [u.a.] : De Gruyter, 1998 50(2011), 1 vom: 17. Sept., Seite 125-128 (DE-627)NLEJ248235222 (DE-600)1492732-9 1437-4331 nnns volume:50 year:2011 number:1 day:17 month:09 pages:125-128 extent:4 https://doi.org/10.1515/cclm.2011.713 Deutschlandweit zugänglich GBV_USEFLAG_U ZDB-1-DGR GBV_NL_ARTICLE AR 50 2011 1 17 09 125-128 4 |
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10.1515/cclm.2011.713 doi artikel_Grundlieferung.pp (DE-627)NLEJ246736151 DE-627 ger DE-627 rakwb Synovial and serum levels of uncarboxylated matrix Gla-protein (ucMGP) in patients with arthritis Walter de Gruyter 2011 4 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Background: Matrix Gla-protein (MGP) is a calcification inhibitor produced by cartilage and vessel walls. Arthritis is defined by inflammation, cartilage and bone destruction/formation and articular calcifications. Our objectives were to evaluate ucMGP levels in synovial fluid (SF) in arthritis patients and to investigate the relationship between local and circulating ucMGP and their association with age and inflammation. Methods: Arthritis patients (n=26) with knee joint effusion and controls (n=30) underwent an ultrasonographic knee examination for articular calcifications assessment. Patients were divided into inflammatory and non-inflammatory groups. ucMGP levels were determined in serum and SF using a competitive ELISA assay. Results: Within the arthritis patients, the inflammatory group had the lowest ucMGP serum levels, and the highest levels of synovial ucMGP. Furthermore, the inflammatory group had significantly (p<0.05) higher RucMGP (synovial ucMGP/serum ucMGP*100) than the non-inflammatory group [36 (17–69) vs. 24 (5–55)], and this parameter positively correlated (r=0.4; p<0.05) with the erythrocyte sedimentation rate (ESR). No correlation was found between age and local or circulating ucMGP in patients and controls. Conclusions: The ucMGP assay can be used for determination of MGP in SF, and combined assessment of ucMGP in serum and SF could potentially serve as a joint inflammatory marker in arthritis patients. Walter de Gruyter Online Zeitschriften arthritis articular calcifications inflammation matrix Gla-protein synovial fluid Silaghi, Ciprian N. oth Fodor, Dana oth Cristea, Victor oth Crăciun, Alexandra M. oth Enthalten in Clinical chemistry and laboratory medicine Berlin [u.a.] : De Gruyter, 1998 50(2011), 1 vom: 17. Sept., Seite 125-128 (DE-627)NLEJ248235222 (DE-600)1492732-9 1437-4331 nnns volume:50 year:2011 number:1 day:17 month:09 pages:125-128 extent:4 https://doi.org/10.1515/cclm.2011.713 Deutschlandweit zugänglich GBV_USEFLAG_U ZDB-1-DGR GBV_NL_ARTICLE AR 50 2011 1 17 09 125-128 4 |
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10.1515/cclm.2011.713 doi artikel_Grundlieferung.pp (DE-627)NLEJ246736151 DE-627 ger DE-627 rakwb Synovial and serum levels of uncarboxylated matrix Gla-protein (ucMGP) in patients with arthritis Walter de Gruyter 2011 4 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Background: Matrix Gla-protein (MGP) is a calcification inhibitor produced by cartilage and vessel walls. Arthritis is defined by inflammation, cartilage and bone destruction/formation and articular calcifications. Our objectives were to evaluate ucMGP levels in synovial fluid (SF) in arthritis patients and to investigate the relationship between local and circulating ucMGP and their association with age and inflammation. Methods: Arthritis patients (n=26) with knee joint effusion and controls (n=30) underwent an ultrasonographic knee examination for articular calcifications assessment. Patients were divided into inflammatory and non-inflammatory groups. ucMGP levels were determined in serum and SF using a competitive ELISA assay. Results: Within the arthritis patients, the inflammatory group had the lowest ucMGP serum levels, and the highest levels of synovial ucMGP. Furthermore, the inflammatory group had significantly (p<0.05) higher RucMGP (synovial ucMGP/serum ucMGP*100) than the non-inflammatory group [36 (17–69) vs. 24 (5–55)], and this parameter positively correlated (r=0.4; p<0.05) with the erythrocyte sedimentation rate (ESR). No correlation was found between age and local or circulating ucMGP in patients and controls. Conclusions: The ucMGP assay can be used for determination of MGP in SF, and combined assessment of ucMGP in serum and SF could potentially serve as a joint inflammatory marker in arthritis patients. Walter de Gruyter Online Zeitschriften arthritis articular calcifications inflammation matrix Gla-protein synovial fluid Silaghi, Ciprian N. oth Fodor, Dana oth Cristea, Victor oth Crăciun, Alexandra M. oth Enthalten in Clinical chemistry and laboratory medicine Berlin [u.a.] : De Gruyter, 1998 50(2011), 1 vom: 17. Sept., Seite 125-128 (DE-627)NLEJ248235222 (DE-600)1492732-9 1437-4331 nnns volume:50 year:2011 number:1 day:17 month:09 pages:125-128 extent:4 https://doi.org/10.1515/cclm.2011.713 Deutschlandweit zugänglich GBV_USEFLAG_U ZDB-1-DGR GBV_NL_ARTICLE AR 50 2011 1 17 09 125-128 4 |
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10.1515/cclm.2011.713 doi artikel_Grundlieferung.pp (DE-627)NLEJ246736151 DE-627 ger DE-627 rakwb Synovial and serum levels of uncarboxylated matrix Gla-protein (ucMGP) in patients with arthritis Walter de Gruyter 2011 4 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Background: Matrix Gla-protein (MGP) is a calcification inhibitor produced by cartilage and vessel walls. Arthritis is defined by inflammation, cartilage and bone destruction/formation and articular calcifications. Our objectives were to evaluate ucMGP levels in synovial fluid (SF) in arthritis patients and to investigate the relationship between local and circulating ucMGP and their association with age and inflammation. Methods: Arthritis patients (n=26) with knee joint effusion and controls (n=30) underwent an ultrasonographic knee examination for articular calcifications assessment. Patients were divided into inflammatory and non-inflammatory groups. ucMGP levels were determined in serum and SF using a competitive ELISA assay. Results: Within the arthritis patients, the inflammatory group had the lowest ucMGP serum levels, and the highest levels of synovial ucMGP. Furthermore, the inflammatory group had significantly (p<0.05) higher RucMGP (synovial ucMGP/serum ucMGP*100) than the non-inflammatory group [36 (17–69) vs. 24 (5–55)], and this parameter positively correlated (r=0.4; p<0.05) with the erythrocyte sedimentation rate (ESR). No correlation was found between age and local or circulating ucMGP in patients and controls. Conclusions: The ucMGP assay can be used for determination of MGP in SF, and combined assessment of ucMGP in serum and SF could potentially serve as a joint inflammatory marker in arthritis patients. Walter de Gruyter Online Zeitschriften arthritis articular calcifications inflammation matrix Gla-protein synovial fluid Silaghi, Ciprian N. oth Fodor, Dana oth Cristea, Victor oth Crăciun, Alexandra M. oth Enthalten in Clinical chemistry and laboratory medicine Berlin [u.a.] : De Gruyter, 1998 50(2011), 1 vom: 17. Sept., Seite 125-128 (DE-627)NLEJ248235222 (DE-600)1492732-9 1437-4331 nnns volume:50 year:2011 number:1 day:17 month:09 pages:125-128 extent:4 https://doi.org/10.1515/cclm.2011.713 Deutschlandweit zugänglich GBV_USEFLAG_U ZDB-1-DGR GBV_NL_ARTICLE AR 50 2011 1 17 09 125-128 4 |
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synovial and serum levels of uncarboxylated matrix gla-protein (ucmgp) in patients with arthritis |
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Synovial and serum levels of uncarboxylated matrix Gla-protein (ucMGP) in patients with arthritis |
| abstract |
Background: Matrix Gla-protein (MGP) is a calcification inhibitor produced by cartilage and vessel walls. Arthritis is defined by inflammation, cartilage and bone destruction/formation and articular calcifications. Our objectives were to evaluate ucMGP levels in synovial fluid (SF) in arthritis patients and to investigate the relationship between local and circulating ucMGP and their association with age and inflammation. Methods: Arthritis patients (n=26) with knee joint effusion and controls (n=30) underwent an ultrasonographic knee examination for articular calcifications assessment. Patients were divided into inflammatory and non-inflammatory groups. ucMGP levels were determined in serum and SF using a competitive ELISA assay. Results: Within the arthritis patients, the inflammatory group had the lowest ucMGP serum levels, and the highest levels of synovial ucMGP. Furthermore, the inflammatory group had significantly (p<0.05) higher RucMGP (synovial ucMGP/serum ucMGP*100) than the non-inflammatory group [36 (17–69) vs. 24 (5–55)], and this parameter positively correlated (r=0.4; p<0.05) with the erythrocyte sedimentation rate (ESR). No correlation was found between age and local or circulating ucMGP in patients and controls. Conclusions: The ucMGP assay can be used for determination of MGP in SF, and combined assessment of ucMGP in serum and SF could potentially serve as a joint inflammatory marker in arthritis patients. |
| abstractGer |
Background: Matrix Gla-protein (MGP) is a calcification inhibitor produced by cartilage and vessel walls. Arthritis is defined by inflammation, cartilage and bone destruction/formation and articular calcifications. Our objectives were to evaluate ucMGP levels in synovial fluid (SF) in arthritis patients and to investigate the relationship between local and circulating ucMGP and their association with age and inflammation. Methods: Arthritis patients (n=26) with knee joint effusion and controls (n=30) underwent an ultrasonographic knee examination for articular calcifications assessment. Patients were divided into inflammatory and non-inflammatory groups. ucMGP levels were determined in serum and SF using a competitive ELISA assay. Results: Within the arthritis patients, the inflammatory group had the lowest ucMGP serum levels, and the highest levels of synovial ucMGP. Furthermore, the inflammatory group had significantly (p<0.05) higher RucMGP (synovial ucMGP/serum ucMGP*100) than the non-inflammatory group [36 (17–69) vs. 24 (5–55)], and this parameter positively correlated (r=0.4; p<0.05) with the erythrocyte sedimentation rate (ESR). No correlation was found between age and local or circulating ucMGP in patients and controls. Conclusions: The ucMGP assay can be used for determination of MGP in SF, and combined assessment of ucMGP in serum and SF could potentially serve as a joint inflammatory marker in arthritis patients. |
| abstract_unstemmed |
Background: Matrix Gla-protein (MGP) is a calcification inhibitor produced by cartilage and vessel walls. Arthritis is defined by inflammation, cartilage and bone destruction/formation and articular calcifications. Our objectives were to evaluate ucMGP levels in synovial fluid (SF) in arthritis patients and to investigate the relationship between local and circulating ucMGP and their association with age and inflammation. Methods: Arthritis patients (n=26) with knee joint effusion and controls (n=30) underwent an ultrasonographic knee examination for articular calcifications assessment. Patients were divided into inflammatory and non-inflammatory groups. ucMGP levels were determined in serum and SF using a competitive ELISA assay. Results: Within the arthritis patients, the inflammatory group had the lowest ucMGP serum levels, and the highest levels of synovial ucMGP. Furthermore, the inflammatory group had significantly (p<0.05) higher RucMGP (synovial ucMGP/serum ucMGP*100) than the non-inflammatory group [36 (17–69) vs. 24 (5–55)], and this parameter positively correlated (r=0.4; p<0.05) with the erythrocyte sedimentation rate (ESR). No correlation was found between age and local or circulating ucMGP in patients and controls. Conclusions: The ucMGP assay can be used for determination of MGP in SF, and combined assessment of ucMGP in serum and SF could potentially serve as a joint inflammatory marker in arthritis patients. |
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Synovial and serum levels of uncarboxylated matrix Gla-protein (ucMGP) in patients with arthritis |
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Silaghi, Ciprian N. Fodor, Dana Cristea, Victor Crăciun, Alexandra M. |
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Silaghi, Ciprian N. Fodor, Dana Cristea, Victor Crăciun, Alexandra M. |
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10.1515/cclm.2011.713 |
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2024-07-06T09:14:01.347Z |
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