An on-line solid phase extraction procedure for the routine quantification of caspofungin by liquid chromatography-tandem mass spectrometry
Background:Extensive sets of data are required to investigate the potential use of a therapeutic drug monitoring with individualization of dosage of the antimycotic compound caspofungin. The goal was to develop an improved liquid chromatography-tandem mass spectrometry (LC-MS/MS) method for this aim...
Ausführliche Beschreibung
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Erschienen: |
Walter de Gruyter ; 2011 |
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Schlagwörter: |
liquid chromatography-tandem mass spectrometry (LC-MS/MS) |
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4 |
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Walter de Gruyter Online Zeitschriften |
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Enthalten in: Clinical chemistry and laboratory medicine - Berlin [u.a.] : De Gruyter, 1998, 50(2011), 3 vom: 30. Nov., Seite 521-524 |
Übergeordnetes Werk: |
volume:50 ; year:2011 ; number:3 ; day:30 ; month:11 ; pages:521-524 ; extent:4 |
Links: |
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DOI / URN: |
10.1515/cclm.2011.802 |
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NLEJ246737026 |
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10.1515/cclm.2011.802 doi artikel_Grundlieferung.pp (DE-627)NLEJ246737026 DE-627 ger DE-627 rakwb An on-line solid phase extraction procedure for the routine quantification of caspofungin by liquid chromatography-tandem mass spectrometry Walter de Gruyter 2011 4 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Background:Extensive sets of data are required to investigate the potential use of a therapeutic drug monitoring with individualization of dosage of the antimycotic compound caspofungin. The goal was to develop an improved liquid chromatography-tandem mass spectrometry (LC-MS/MS) method for this aim. Methods:Following protein precipitation, on-line solid phase extraction was performed for sample preparation. As the internal standard compound the veterinary drug tylosin was used. A standard validation protocol was applied. Results:Good reproducibility and accuracy of the method were observed. On-line solid phase extraction resulted in a convenient work-flow and good robustness of the method. Conclusions:This improved LC-MS/MS method was found reliable and convenient. It can be suggested for further work on the clinical pharmacology of caspofungin in the setting of clinical research laboratories. Walter de Gruyter Online Zeitschriften caspofungin liquid chromatography-tandem mass spectrometry (LC-MS/MS) on-line solid phase extraction (SPE) tylosin Kirchhoff, Fabian oth Maier, Barbara oth Rieger, Christina oth Ostermann, Helmut oth Spöhrer, Ute oth Vogeser, Michael oth Enthalten in Clinical chemistry and laboratory medicine Berlin [u.a.] : De Gruyter, 1998 50(2011), 3 vom: 30. Nov., Seite 521-524 (DE-627)NLEJ248235222 (DE-600)1492732-9 1437-4331 nnns volume:50 year:2011 number:3 day:30 month:11 pages:521-524 extent:4 https://doi.org/10.1515/cclm.2011.802 Deutschlandweit zugänglich GBV_USEFLAG_U ZDB-1-DGR GBV_NL_ARTICLE AR 50 2011 3 30 11 521-524 4 |
spelling |
10.1515/cclm.2011.802 doi artikel_Grundlieferung.pp (DE-627)NLEJ246737026 DE-627 ger DE-627 rakwb An on-line solid phase extraction procedure for the routine quantification of caspofungin by liquid chromatography-tandem mass spectrometry Walter de Gruyter 2011 4 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Background:Extensive sets of data are required to investigate the potential use of a therapeutic drug monitoring with individualization of dosage of the antimycotic compound caspofungin. The goal was to develop an improved liquid chromatography-tandem mass spectrometry (LC-MS/MS) method for this aim. Methods:Following protein precipitation, on-line solid phase extraction was performed for sample preparation. As the internal standard compound the veterinary drug tylosin was used. A standard validation protocol was applied. Results:Good reproducibility and accuracy of the method were observed. On-line solid phase extraction resulted in a convenient work-flow and good robustness of the method. Conclusions:This improved LC-MS/MS method was found reliable and convenient. It can be suggested for further work on the clinical pharmacology of caspofungin in the setting of clinical research laboratories. Walter de Gruyter Online Zeitschriften caspofungin liquid chromatography-tandem mass spectrometry (LC-MS/MS) on-line solid phase extraction (SPE) tylosin Kirchhoff, Fabian oth Maier, Barbara oth Rieger, Christina oth Ostermann, Helmut oth Spöhrer, Ute oth Vogeser, Michael oth Enthalten in Clinical chemistry and laboratory medicine Berlin [u.a.] : De Gruyter, 1998 50(2011), 3 vom: 30. Nov., Seite 521-524 (DE-627)NLEJ248235222 (DE-600)1492732-9 1437-4331 nnns volume:50 year:2011 number:3 day:30 month:11 pages:521-524 extent:4 https://doi.org/10.1515/cclm.2011.802 Deutschlandweit zugänglich GBV_USEFLAG_U ZDB-1-DGR GBV_NL_ARTICLE AR 50 2011 3 30 11 521-524 4 |
allfields_unstemmed |
10.1515/cclm.2011.802 doi artikel_Grundlieferung.pp (DE-627)NLEJ246737026 DE-627 ger DE-627 rakwb An on-line solid phase extraction procedure for the routine quantification of caspofungin by liquid chromatography-tandem mass spectrometry Walter de Gruyter 2011 4 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Background:Extensive sets of data are required to investigate the potential use of a therapeutic drug monitoring with individualization of dosage of the antimycotic compound caspofungin. The goal was to develop an improved liquid chromatography-tandem mass spectrometry (LC-MS/MS) method for this aim. Methods:Following protein precipitation, on-line solid phase extraction was performed for sample preparation. As the internal standard compound the veterinary drug tylosin was used. A standard validation protocol was applied. Results:Good reproducibility and accuracy of the method were observed. On-line solid phase extraction resulted in a convenient work-flow and good robustness of the method. Conclusions:This improved LC-MS/MS method was found reliable and convenient. It can be suggested for further work on the clinical pharmacology of caspofungin in the setting of clinical research laboratories. Walter de Gruyter Online Zeitschriften caspofungin liquid chromatography-tandem mass spectrometry (LC-MS/MS) on-line solid phase extraction (SPE) tylosin Kirchhoff, Fabian oth Maier, Barbara oth Rieger, Christina oth Ostermann, Helmut oth Spöhrer, Ute oth Vogeser, Michael oth Enthalten in Clinical chemistry and laboratory medicine Berlin [u.a.] : De Gruyter, 1998 50(2011), 3 vom: 30. Nov., Seite 521-524 (DE-627)NLEJ248235222 (DE-600)1492732-9 1437-4331 nnns volume:50 year:2011 number:3 day:30 month:11 pages:521-524 extent:4 https://doi.org/10.1515/cclm.2011.802 Deutschlandweit zugänglich GBV_USEFLAG_U ZDB-1-DGR GBV_NL_ARTICLE AR 50 2011 3 30 11 521-524 4 |
allfieldsGer |
10.1515/cclm.2011.802 doi artikel_Grundlieferung.pp (DE-627)NLEJ246737026 DE-627 ger DE-627 rakwb An on-line solid phase extraction procedure for the routine quantification of caspofungin by liquid chromatography-tandem mass spectrometry Walter de Gruyter 2011 4 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Background:Extensive sets of data are required to investigate the potential use of a therapeutic drug monitoring with individualization of dosage of the antimycotic compound caspofungin. The goal was to develop an improved liquid chromatography-tandem mass spectrometry (LC-MS/MS) method for this aim. Methods:Following protein precipitation, on-line solid phase extraction was performed for sample preparation. As the internal standard compound the veterinary drug tylosin was used. A standard validation protocol was applied. Results:Good reproducibility and accuracy of the method were observed. On-line solid phase extraction resulted in a convenient work-flow and good robustness of the method. Conclusions:This improved LC-MS/MS method was found reliable and convenient. It can be suggested for further work on the clinical pharmacology of caspofungin in the setting of clinical research laboratories. Walter de Gruyter Online Zeitschriften caspofungin liquid chromatography-tandem mass spectrometry (LC-MS/MS) on-line solid phase extraction (SPE) tylosin Kirchhoff, Fabian oth Maier, Barbara oth Rieger, Christina oth Ostermann, Helmut oth Spöhrer, Ute oth Vogeser, Michael oth Enthalten in Clinical chemistry and laboratory medicine Berlin [u.a.] : De Gruyter, 1998 50(2011), 3 vom: 30. Nov., Seite 521-524 (DE-627)NLEJ248235222 (DE-600)1492732-9 1437-4331 nnns volume:50 year:2011 number:3 day:30 month:11 pages:521-524 extent:4 https://doi.org/10.1515/cclm.2011.802 Deutschlandweit zugänglich GBV_USEFLAG_U ZDB-1-DGR GBV_NL_ARTICLE AR 50 2011 3 30 11 521-524 4 |
allfieldsSound |
10.1515/cclm.2011.802 doi artikel_Grundlieferung.pp (DE-627)NLEJ246737026 DE-627 ger DE-627 rakwb An on-line solid phase extraction procedure for the routine quantification of caspofungin by liquid chromatography-tandem mass spectrometry Walter de Gruyter 2011 4 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Background:Extensive sets of data are required to investigate the potential use of a therapeutic drug monitoring with individualization of dosage of the antimycotic compound caspofungin. The goal was to develop an improved liquid chromatography-tandem mass spectrometry (LC-MS/MS) method for this aim. Methods:Following protein precipitation, on-line solid phase extraction was performed for sample preparation. As the internal standard compound the veterinary drug tylosin was used. A standard validation protocol was applied. Results:Good reproducibility and accuracy of the method were observed. On-line solid phase extraction resulted in a convenient work-flow and good robustness of the method. Conclusions:This improved LC-MS/MS method was found reliable and convenient. It can be suggested for further work on the clinical pharmacology of caspofungin in the setting of clinical research laboratories. Walter de Gruyter Online Zeitschriften caspofungin liquid chromatography-tandem mass spectrometry (LC-MS/MS) on-line solid phase extraction (SPE) tylosin Kirchhoff, Fabian oth Maier, Barbara oth Rieger, Christina oth Ostermann, Helmut oth Spöhrer, Ute oth Vogeser, Michael oth Enthalten in Clinical chemistry and laboratory medicine Berlin [u.a.] : De Gruyter, 1998 50(2011), 3 vom: 30. Nov., Seite 521-524 (DE-627)NLEJ248235222 (DE-600)1492732-9 1437-4331 nnns volume:50 year:2011 number:3 day:30 month:11 pages:521-524 extent:4 https://doi.org/10.1515/cclm.2011.802 Deutschlandweit zugänglich GBV_USEFLAG_U ZDB-1-DGR GBV_NL_ARTICLE AR 50 2011 3 30 11 521-524 4 |
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an on-line solid phase extraction procedure for the routine quantification of caspofungin by liquid chromatography-tandem mass spectrometry |
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An on-line solid phase extraction procedure for the routine quantification of caspofungin by liquid chromatography-tandem mass spectrometry |
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Background:Extensive sets of data are required to investigate the potential use of a therapeutic drug monitoring with individualization of dosage of the antimycotic compound caspofungin. The goal was to develop an improved liquid chromatography-tandem mass spectrometry (LC-MS/MS) method for this aim. Methods:Following protein precipitation, on-line solid phase extraction was performed for sample preparation. As the internal standard compound the veterinary drug tylosin was used. A standard validation protocol was applied. Results:Good reproducibility and accuracy of the method were observed. On-line solid phase extraction resulted in a convenient work-flow and good robustness of the method. Conclusions:This improved LC-MS/MS method was found reliable and convenient. It can be suggested for further work on the clinical pharmacology of caspofungin in the setting of clinical research laboratories. |
abstractGer |
Background:Extensive sets of data are required to investigate the potential use of a therapeutic drug monitoring with individualization of dosage of the antimycotic compound caspofungin. The goal was to develop an improved liquid chromatography-tandem mass spectrometry (LC-MS/MS) method for this aim. Methods:Following protein precipitation, on-line solid phase extraction was performed for sample preparation. As the internal standard compound the veterinary drug tylosin was used. A standard validation protocol was applied. Results:Good reproducibility and accuracy of the method were observed. On-line solid phase extraction resulted in a convenient work-flow and good robustness of the method. Conclusions:This improved LC-MS/MS method was found reliable and convenient. It can be suggested for further work on the clinical pharmacology of caspofungin in the setting of clinical research laboratories. |
abstract_unstemmed |
Background:Extensive sets of data are required to investigate the potential use of a therapeutic drug monitoring with individualization of dosage of the antimycotic compound caspofungin. The goal was to develop an improved liquid chromatography-tandem mass spectrometry (LC-MS/MS) method for this aim. Methods:Following protein precipitation, on-line solid phase extraction was performed for sample preparation. As the internal standard compound the veterinary drug tylosin was used. A standard validation protocol was applied. Results:Good reproducibility and accuracy of the method were observed. On-line solid phase extraction resulted in a convenient work-flow and good robustness of the method. Conclusions:This improved LC-MS/MS method was found reliable and convenient. It can be suggested for further work on the clinical pharmacology of caspofungin in the setting of clinical research laboratories. |
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<?xml version="1.0" encoding="UTF-8"?><collection xmlns="http://www.loc.gov/MARC21/slim"><record><leader>01000caa a22002652 4500</leader><controlfield tag="001">NLEJ246737026</controlfield><controlfield tag="003">DE-627</controlfield><controlfield tag="005">20230506145615.0</controlfield><controlfield tag="007">cr uuu---uuuuu</controlfield><controlfield tag="008">220814s2011 xx |||||o 00| ||und c</controlfield><datafield tag="024" ind1="7" ind2=" "><subfield code="a">10.1515/cclm.2011.802</subfield><subfield code="2">doi</subfield></datafield><datafield tag="028" ind1="5" ind2="2"><subfield code="a">artikel_Grundlieferung.pp</subfield></datafield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(DE-627)NLEJ246737026</subfield></datafield><datafield tag="040" ind1=" " ind2=" "><subfield code="a">DE-627</subfield><subfield code="b">ger</subfield><subfield code="c">DE-627</subfield><subfield code="e">rakwb</subfield></datafield><datafield tag="245" ind1="1" ind2="0"><subfield code="a">An on-line solid phase extraction procedure for the routine quantification of caspofungin by liquid chromatography-tandem mass spectrometry</subfield></datafield><datafield tag="264" ind1=" " ind2="1"><subfield code="b">Walter de Gruyter</subfield><subfield code="c">2011</subfield></datafield><datafield tag="300" ind1=" " ind2=" "><subfield code="a">4</subfield></datafield><datafield tag="336" ind1=" " ind2=" "><subfield code="a">Text</subfield><subfield code="b">txt</subfield><subfield code="2">rdacontent</subfield></datafield><datafield tag="337" ind1=" " ind2=" "><subfield code="a">Computermedien</subfield><subfield code="b">c</subfield><subfield code="2">rdamedia</subfield></datafield><datafield tag="338" ind1=" " ind2=" "><subfield code="a">Online-Ressource</subfield><subfield code="b">cr</subfield><subfield code="2">rdacarrier</subfield></datafield><datafield tag="520" ind1=" " ind2=" "><subfield code="a">Background:Extensive sets of data are required to investigate the potential use of a therapeutic drug monitoring with individualization of dosage of the antimycotic compound caspofungin. The goal was to develop an improved liquid chromatography-tandem mass spectrometry (LC-MS/MS) method for this aim. Methods:Following protein precipitation, on-line solid phase extraction was performed for sample preparation. As the internal standard compound the veterinary drug tylosin was used. A standard validation protocol was applied. Results:Good reproducibility and accuracy of the method were observed. On-line solid phase extraction resulted in a convenient work-flow and good robustness of the method. Conclusions:This improved LC-MS/MS method was found reliable and convenient. It can be suggested for further work on the clinical pharmacology of caspofungin in the setting of clinical research laboratories.</subfield></datafield><datafield tag="533" ind1=" " ind2=" "><subfield code="f">Walter de Gruyter Online Zeitschriften</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">caspofungin</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">liquid chromatography-tandem mass spectrometry (LC-MS/MS)</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">on-line solid phase extraction (SPE)</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">tylosin</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Kirchhoff, Fabian</subfield><subfield code="4">oth</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Maier, Barbara</subfield><subfield code="4">oth</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Rieger, Christina</subfield><subfield code="4">oth</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Ostermann, Helmut</subfield><subfield code="4">oth</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Spöhrer, Ute</subfield><subfield code="4">oth</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Vogeser, Michael</subfield><subfield code="4">oth</subfield></datafield><datafield tag="773" ind1="0" ind2="8"><subfield code="i">Enthalten in</subfield><subfield code="t">Clinical chemistry and laboratory medicine</subfield><subfield code="d">Berlin [u.a.] : De Gruyter, 1998</subfield><subfield code="g">50(2011), 3 vom: 30. Nov., Seite 521-524</subfield><subfield code="w">(DE-627)NLEJ248235222</subfield><subfield code="w">(DE-600)1492732-9</subfield><subfield code="x">1437-4331</subfield><subfield code="7">nnns</subfield></datafield><datafield tag="773" ind1="1" ind2="8"><subfield code="g">volume:50</subfield><subfield code="g">year:2011</subfield><subfield code="g">number:3</subfield><subfield code="g">day:30</subfield><subfield code="g">month:11</subfield><subfield code="g">pages:521-524</subfield><subfield code="g">extent:4</subfield></datafield><datafield tag="856" ind1="4" ind2="0"><subfield code="u">https://doi.org/10.1515/cclm.2011.802</subfield><subfield code="z">Deutschlandweit zugänglich</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_USEFLAG_U</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">ZDB-1-DGR</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_NL_ARTICLE</subfield></datafield><datafield tag="951" ind1=" " ind2=" "><subfield code="a">AR</subfield></datafield><datafield tag="952" ind1=" " ind2=" "><subfield code="d">50</subfield><subfield code="j">2011</subfield><subfield code="e">3</subfield><subfield code="b">30</subfield><subfield code="c">11</subfield><subfield code="h">521-524</subfield><subfield code="g">4</subfield></datafield></record></collection>
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