Cadherin-related protein 24 induces morphological changes and partial cell polarization by facilitating direct cell-cell interactions
Cadherin-related protein 24 (CDHR24) is a potential tumor suppressor located apically as well as laterally in polarized cells. Here, the role of CDHR24 in contributing to cell morphology and polarity is examined. CDHR24 was predominantly localized at the nonattached part of nonpolarizing cells while...
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E-Artikel |
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| Erschienen: |
Walter de Gruyter ; 2012 |
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9 |
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| Reproduktion: |
Walter de Gruyter Online Zeitschriften |
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| Übergeordnetes Werk: |
Enthalten in: Biological chemistry - Berlin [u.a.] : de Gruyter, 1996, 393, 6, Seite 495-503 |
| Übergeordnetes Werk: |
volume:393 ; number:6 ; pages:495-503 ; extent:9 |
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| DOI / URN: |
10.1515/hsz-2011-0203 |
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NLEJ246931167 |
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| 520 | |a Cadherin-related protein 24 (CDHR24) is a potential tumor suppressor located apically as well as laterally in polarized cells. Here, the role of CDHR24 in contributing to cell morphology and polarity is examined. CDHR24 was predominantly localized at the nonattached part of nonpolarizing cells while another apically sorted protein, aminopeptidase N, was equally distributed over the plasma membrane. Furthermore, CDHR24 expression induced cell aggregation capacity, indicating direct cell-cell interaction. The transepithelial resistance, however, was elevated in polarized MDCK cells, but not in nonpolarizing CHO cells. Our data propose a model in which CDHR24 is directly involved in cell and tissue morphogenesis. | ||
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10.1515/hsz-2011-0203 doi artikel_Grundlieferung.pp (DE-627)NLEJ246931167 DE-627 ger DE-627 rakwb Cadherin-related protein 24 induces morphological changes and partial cell polarization by facilitating direct cell-cell interactions Walter de Gruyter 2012 9 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Cadherin-related protein 24 (CDHR24) is a potential tumor suppressor located apically as well as laterally in polarized cells. Here, the role of CDHR24 in contributing to cell morphology and polarity is examined. CDHR24 was predominantly localized at the nonattached part of nonpolarizing cells while another apically sorted protein, aminopeptidase N, was equally distributed over the plasma membrane. Furthermore, CDHR24 expression induced cell aggregation capacity, indicating direct cell-cell interaction. The transepithelial resistance, however, was elevated in polarized MDCK cells, but not in nonpolarizing CHO cells. Our data propose a model in which CDHR24 is directly involved in cell and tissue morphogenesis. Walter de Gruyter Online Zeitschriften cell-cell interaction cell differentiation cell polarity protein-protein interactions protein sorting tumor suppressor Behrendt, Marc oth Krahn, Michael P. oth Al-Bayati, Hiam oth Amiri, Mahdi oth Rizk, Sandra oth Naim, Hassan Y. oth Enthalten in Biological chemistry Berlin [u.a.] : de Gruyter, 1996 393, 6, Seite 495-503 (DE-627)NLEJ248235095 (DE-600)1466062-3 1437-4315 nnns volume:393 number:6 pages:495-503 extent:9 https://doi.org/10.1515/hsz-2011-0203 Deutschlandweit zugänglich GBV_USEFLAG_U ZDB-1-DGR GBV_NL_ARTICLE AR 393 6 495-503 9 |
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10.1515/hsz-2011-0203 doi artikel_Grundlieferung.pp (DE-627)NLEJ246931167 DE-627 ger DE-627 rakwb Cadherin-related protein 24 induces morphological changes and partial cell polarization by facilitating direct cell-cell interactions Walter de Gruyter 2012 9 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Cadherin-related protein 24 (CDHR24) is a potential tumor suppressor located apically as well as laterally in polarized cells. Here, the role of CDHR24 in contributing to cell morphology and polarity is examined. CDHR24 was predominantly localized at the nonattached part of nonpolarizing cells while another apically sorted protein, aminopeptidase N, was equally distributed over the plasma membrane. Furthermore, CDHR24 expression induced cell aggregation capacity, indicating direct cell-cell interaction. The transepithelial resistance, however, was elevated in polarized MDCK cells, but not in nonpolarizing CHO cells. Our data propose a model in which CDHR24 is directly involved in cell and tissue morphogenesis. Walter de Gruyter Online Zeitschriften cell-cell interaction cell differentiation cell polarity protein-protein interactions protein sorting tumor suppressor Behrendt, Marc oth Krahn, Michael P. oth Al-Bayati, Hiam oth Amiri, Mahdi oth Rizk, Sandra oth Naim, Hassan Y. oth Enthalten in Biological chemistry Berlin [u.a.] : de Gruyter, 1996 393, 6, Seite 495-503 (DE-627)NLEJ248235095 (DE-600)1466062-3 1437-4315 nnns volume:393 number:6 pages:495-503 extent:9 https://doi.org/10.1515/hsz-2011-0203 Deutschlandweit zugänglich GBV_USEFLAG_U ZDB-1-DGR GBV_NL_ARTICLE AR 393 6 495-503 9 |
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10.1515/hsz-2011-0203 doi artikel_Grundlieferung.pp (DE-627)NLEJ246931167 DE-627 ger DE-627 rakwb Cadherin-related protein 24 induces morphological changes and partial cell polarization by facilitating direct cell-cell interactions Walter de Gruyter 2012 9 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Cadherin-related protein 24 (CDHR24) is a potential tumor suppressor located apically as well as laterally in polarized cells. Here, the role of CDHR24 in contributing to cell morphology and polarity is examined. CDHR24 was predominantly localized at the nonattached part of nonpolarizing cells while another apically sorted protein, aminopeptidase N, was equally distributed over the plasma membrane. Furthermore, CDHR24 expression induced cell aggregation capacity, indicating direct cell-cell interaction. The transepithelial resistance, however, was elevated in polarized MDCK cells, but not in nonpolarizing CHO cells. Our data propose a model in which CDHR24 is directly involved in cell and tissue morphogenesis. Walter de Gruyter Online Zeitschriften cell-cell interaction cell differentiation cell polarity protein-protein interactions protein sorting tumor suppressor Behrendt, Marc oth Krahn, Michael P. oth Al-Bayati, Hiam oth Amiri, Mahdi oth Rizk, Sandra oth Naim, Hassan Y. oth Enthalten in Biological chemistry Berlin [u.a.] : de Gruyter, 1996 393, 6, Seite 495-503 (DE-627)NLEJ248235095 (DE-600)1466062-3 1437-4315 nnns volume:393 number:6 pages:495-503 extent:9 https://doi.org/10.1515/hsz-2011-0203 Deutschlandweit zugänglich GBV_USEFLAG_U ZDB-1-DGR GBV_NL_ARTICLE AR 393 6 495-503 9 |
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10.1515/hsz-2011-0203 doi artikel_Grundlieferung.pp (DE-627)NLEJ246931167 DE-627 ger DE-627 rakwb Cadherin-related protein 24 induces morphological changes and partial cell polarization by facilitating direct cell-cell interactions Walter de Gruyter 2012 9 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Cadherin-related protein 24 (CDHR24) is a potential tumor suppressor located apically as well as laterally in polarized cells. Here, the role of CDHR24 in contributing to cell morphology and polarity is examined. CDHR24 was predominantly localized at the nonattached part of nonpolarizing cells while another apically sorted protein, aminopeptidase N, was equally distributed over the plasma membrane. Furthermore, CDHR24 expression induced cell aggregation capacity, indicating direct cell-cell interaction. The transepithelial resistance, however, was elevated in polarized MDCK cells, but not in nonpolarizing CHO cells. Our data propose a model in which CDHR24 is directly involved in cell and tissue morphogenesis. Walter de Gruyter Online Zeitschriften cell-cell interaction cell differentiation cell polarity protein-protein interactions protein sorting tumor suppressor Behrendt, Marc oth Krahn, Michael P. oth Al-Bayati, Hiam oth Amiri, Mahdi oth Rizk, Sandra oth Naim, Hassan Y. oth Enthalten in Biological chemistry Berlin [u.a.] : de Gruyter, 1996 393, 6, Seite 495-503 (DE-627)NLEJ248235095 (DE-600)1466062-3 1437-4315 nnns volume:393 number:6 pages:495-503 extent:9 https://doi.org/10.1515/hsz-2011-0203 Deutschlandweit zugänglich GBV_USEFLAG_U ZDB-1-DGR GBV_NL_ARTICLE AR 393 6 495-503 9 |
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cadherin-related protein 24 induces morphological changes and partial cell polarization by facilitating direct cell-cell interactions |
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Cadherin-related protein 24 induces morphological changes and partial cell polarization by facilitating direct cell-cell interactions |
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Cadherin-related protein 24 (CDHR24) is a potential tumor suppressor located apically as well as laterally in polarized cells. Here, the role of CDHR24 in contributing to cell morphology and polarity is examined. CDHR24 was predominantly localized at the nonattached part of nonpolarizing cells while another apically sorted protein, aminopeptidase N, was equally distributed over the plasma membrane. Furthermore, CDHR24 expression induced cell aggregation capacity, indicating direct cell-cell interaction. The transepithelial resistance, however, was elevated in polarized MDCK cells, but not in nonpolarizing CHO cells. Our data propose a model in which CDHR24 is directly involved in cell and tissue morphogenesis. |
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Cadherin-related protein 24 (CDHR24) is a potential tumor suppressor located apically as well as laterally in polarized cells. Here, the role of CDHR24 in contributing to cell morphology and polarity is examined. CDHR24 was predominantly localized at the nonattached part of nonpolarizing cells while another apically sorted protein, aminopeptidase N, was equally distributed over the plasma membrane. Furthermore, CDHR24 expression induced cell aggregation capacity, indicating direct cell-cell interaction. The transepithelial resistance, however, was elevated in polarized MDCK cells, but not in nonpolarizing CHO cells. Our data propose a model in which CDHR24 is directly involved in cell and tissue morphogenesis. |
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Cadherin-related protein 24 (CDHR24) is a potential tumor suppressor located apically as well as laterally in polarized cells. Here, the role of CDHR24 in contributing to cell morphology and polarity is examined. CDHR24 was predominantly localized at the nonattached part of nonpolarizing cells while another apically sorted protein, aminopeptidase N, was equally distributed over the plasma membrane. Furthermore, CDHR24 expression induced cell aggregation capacity, indicating direct cell-cell interaction. The transepithelial resistance, however, was elevated in polarized MDCK cells, but not in nonpolarizing CHO cells. Our data propose a model in which CDHR24 is directly involved in cell and tissue morphogenesis. |
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<?xml version="1.0" encoding="UTF-8"?><collection xmlns="http://www.loc.gov/MARC21/slim"><record><leader>01000caa a22002652 4500</leader><controlfield tag="001">NLEJ246931167</controlfield><controlfield tag="003">DE-627</controlfield><controlfield tag="005">20230506180008.0</controlfield><controlfield tag="007">cr uuu---uuuuu</controlfield><controlfield tag="008">220814s2012 xx |||||o 00| ||und c</controlfield><datafield tag="024" ind1="7" ind2=" "><subfield code="a">10.1515/hsz-2011-0203</subfield><subfield code="2">doi</subfield></datafield><datafield tag="028" ind1="5" ind2="2"><subfield code="a">artikel_Grundlieferung.pp</subfield></datafield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(DE-627)NLEJ246931167</subfield></datafield><datafield tag="040" ind1=" " ind2=" "><subfield code="a">DE-627</subfield><subfield code="b">ger</subfield><subfield code="c">DE-627</subfield><subfield code="e">rakwb</subfield></datafield><datafield tag="245" ind1="1" ind2="0"><subfield code="a">Cadherin-related protein 24 induces morphological changes and partial cell polarization by facilitating direct cell-cell interactions</subfield></datafield><datafield tag="264" ind1=" " ind2="1"><subfield code="b">Walter de Gruyter</subfield><subfield code="c">2012</subfield></datafield><datafield tag="300" ind1=" " ind2=" "><subfield code="a">9</subfield></datafield><datafield tag="336" ind1=" " ind2=" "><subfield code="a">Text</subfield><subfield code="b">txt</subfield><subfield code="2">rdacontent</subfield></datafield><datafield tag="337" ind1=" " ind2=" "><subfield code="a">Computermedien</subfield><subfield code="b">c</subfield><subfield code="2">rdamedia</subfield></datafield><datafield tag="338" ind1=" " ind2=" "><subfield code="a">Online-Ressource</subfield><subfield code="b">cr</subfield><subfield code="2">rdacarrier</subfield></datafield><datafield tag="520" ind1=" " ind2=" "><subfield code="a">Cadherin-related protein 24 (CDHR24) is a potential tumor suppressor located apically as well as laterally in polarized cells. Here, the role of CDHR24 in contributing to cell morphology and polarity is examined. CDHR24 was predominantly localized at the nonattached part of nonpolarizing cells while another apically sorted protein, aminopeptidase N, was equally distributed over the plasma membrane. Furthermore, CDHR24 expression induced cell aggregation capacity, indicating direct cell-cell interaction. The transepithelial resistance, however, was elevated in polarized MDCK cells, but not in nonpolarizing CHO cells. Our data propose a model in which CDHR24 is directly involved in cell and tissue morphogenesis.</subfield></datafield><datafield tag="533" ind1=" " ind2=" "><subfield code="f">Walter de Gruyter Online Zeitschriften</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">cell-cell interaction</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">cell differentiation</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">cell polarity</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">protein-protein interactions</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">protein sorting</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">tumor suppressor</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Behrendt, Marc</subfield><subfield code="4">oth</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Krahn, Michael P.</subfield><subfield code="4">oth</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Al-Bayati, Hiam</subfield><subfield code="4">oth</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Amiri, Mahdi</subfield><subfield code="4">oth</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Rizk, Sandra</subfield><subfield code="4">oth</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Naim, Hassan Y.</subfield><subfield code="4">oth</subfield></datafield><datafield tag="773" ind1="0" ind2="8"><subfield code="i">Enthalten in</subfield><subfield code="t">Biological chemistry</subfield><subfield code="d">Berlin [u.a.] : de Gruyter, 1996</subfield><subfield code="g">393, 6, Seite 495-503</subfield><subfield code="w">(DE-627)NLEJ248235095</subfield><subfield code="w">(DE-600)1466062-3</subfield><subfield code="x">1437-4315</subfield><subfield code="7">nnns</subfield></datafield><datafield tag="773" ind1="1" ind2="8"><subfield code="g">volume:393</subfield><subfield code="g">number:6</subfield><subfield code="g">pages:495-503</subfield><subfield code="g">extent:9</subfield></datafield><datafield tag="856" ind1="4" ind2="0"><subfield code="u">https://doi.org/10.1515/hsz-2011-0203</subfield><subfield code="z">Deutschlandweit zugänglich</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_USEFLAG_U</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">ZDB-1-DGR</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_NL_ARTICLE</subfield></datafield><datafield tag="951" ind1=" " ind2=" "><subfield code="a">AR</subfield></datafield><datafield tag="952" ind1=" " ind2=" "><subfield code="d">393</subfield><subfield code="e">6</subfield><subfield code="h">495-503</subfield><subfield code="g">9</subfield></datafield></record></collection>
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