Dissecting the impact of Frizzled receptors in Wnt/β-catenin signaling of human mesenchymal stem cells
Wnt/β-catenin signaling is of fundamental importance in the regulation of self-renewal, migration/invasion, and differentiation of human mesenchymal stem cells (hMSCs). Because little information is available about the function of Frizzled receptors (Fzds) as the main receptors of Wnt proteins in hM...
Ausführliche Beschreibung
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De Gruyter ; 2012 |
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15 |
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Walter de Gruyter Online Zeitschriften |
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Enthalten in: Biological chemistry - Berlin [u.a.] : de Gruyter, 1996, 393(2012), 12 vom: 13. Nov., Seite 1433-1447 |
Übergeordnetes Werk: |
volume:393 ; year:2012 ; number:12 ; day:13 ; month:11 ; pages:1433-1447 ; extent:15 |
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DOI / URN: |
10.1515/hsz-2012-0186 |
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NLEJ246932066 |
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10.1515/hsz-2012-0186 doi artikel_Grundlieferung.pp (DE-627)NLEJ246932066 DE-627 ger DE-627 rakwb Dissecting the impact of Frizzled receptors in Wnt/β-catenin signaling of human mesenchymal stem cells De Gruyter 2012 15 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Wnt/β-catenin signaling is of fundamental importance in the regulation of self-renewal, migration/invasion, and differentiation of human mesenchymal stem cells (hMSCs). Because little information is available about the function of Frizzled receptors (Fzds) as the main receptors of Wnt proteins in hMSCs, we first performed comparative Fzd mRNA expression profiling. Fzd9 and Fzd10 were not expressed in hMSCs. While Fzd3 was expressed at low levels in hMSCs, the other Fzds exhibited high expression rates. Activation and repression of Wnt signaling in hMSCs revealed that the expression levels of Fzd1, Fzd6, and Fzd7 are positively correlated with the Wnt/β-catenin activation status, whereas Fzd8 exhibited an inverse relation. For studying the functional relevance of Fzds in Wnt/β-catenin signaling, RNA interference, ectopic expression studies, and rescue approaches were performed in hMSCs carrying a highly sensitive TCF/LEF reporter gene system (Gaussia luciferase). We found that, Fzd1, Fzd5, Fzd7, and Fzd8 are largely involved in Wnt/β-catenin signaling of hMSCs. Moreover, the knockdown of Fzd5 can be compensated by the ectopic expression of Fzd7. Conversely, the ectopic expression of Fzd5 in Fzd7-knockdown hMSCs resulted in a rescue of Wnt/β-catenin signaling, pointing to a functional redundancy of Fzd5 and Fzd7. Walter de Gruyter Online Zeitschriften Frizzled receptors (Fzds) human mesenchymal stem cells (hMSCs) RNA interference TCF/LEF reporter gene system Wnt/β-catenin signaling Kolben, Thomas oth Peröbner, Iris oth Fernsebner, Katharina oth Lechner, Felix oth Geissler, Claudia oth Ruiz-Heinrich, Lourdes oth Capovilla, Simon oth Jochum, Marianne oth Neth, Peter oth Enthalten in Biological chemistry Berlin [u.a.] : de Gruyter, 1996 393(2012), 12 vom: 13. Nov., Seite 1433-1447 (DE-627)NLEJ248235095 (DE-600)1466062-3 1437-4315 nnns volume:393 year:2012 number:12 day:13 month:11 pages:1433-1447 extent:15 https://doi.org/10.1515/hsz-2012-0186 Deutschlandweit zugänglich GBV_USEFLAG_U ZDB-1-DGR GBV_NL_ARTICLE AR 393 2012 12 13 11 1433-1447 15 |
spelling |
10.1515/hsz-2012-0186 doi artikel_Grundlieferung.pp (DE-627)NLEJ246932066 DE-627 ger DE-627 rakwb Dissecting the impact of Frizzled receptors in Wnt/β-catenin signaling of human mesenchymal stem cells De Gruyter 2012 15 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Wnt/β-catenin signaling is of fundamental importance in the regulation of self-renewal, migration/invasion, and differentiation of human mesenchymal stem cells (hMSCs). Because little information is available about the function of Frizzled receptors (Fzds) as the main receptors of Wnt proteins in hMSCs, we first performed comparative Fzd mRNA expression profiling. Fzd9 and Fzd10 were not expressed in hMSCs. While Fzd3 was expressed at low levels in hMSCs, the other Fzds exhibited high expression rates. Activation and repression of Wnt signaling in hMSCs revealed that the expression levels of Fzd1, Fzd6, and Fzd7 are positively correlated with the Wnt/β-catenin activation status, whereas Fzd8 exhibited an inverse relation. For studying the functional relevance of Fzds in Wnt/β-catenin signaling, RNA interference, ectopic expression studies, and rescue approaches were performed in hMSCs carrying a highly sensitive TCF/LEF reporter gene system (Gaussia luciferase). We found that, Fzd1, Fzd5, Fzd7, and Fzd8 are largely involved in Wnt/β-catenin signaling of hMSCs. Moreover, the knockdown of Fzd5 can be compensated by the ectopic expression of Fzd7. Conversely, the ectopic expression of Fzd5 in Fzd7-knockdown hMSCs resulted in a rescue of Wnt/β-catenin signaling, pointing to a functional redundancy of Fzd5 and Fzd7. Walter de Gruyter Online Zeitschriften Frizzled receptors (Fzds) human mesenchymal stem cells (hMSCs) RNA interference TCF/LEF reporter gene system Wnt/β-catenin signaling Kolben, Thomas oth Peröbner, Iris oth Fernsebner, Katharina oth Lechner, Felix oth Geissler, Claudia oth Ruiz-Heinrich, Lourdes oth Capovilla, Simon oth Jochum, Marianne oth Neth, Peter oth Enthalten in Biological chemistry Berlin [u.a.] : de Gruyter, 1996 393(2012), 12 vom: 13. Nov., Seite 1433-1447 (DE-627)NLEJ248235095 (DE-600)1466062-3 1437-4315 nnns volume:393 year:2012 number:12 day:13 month:11 pages:1433-1447 extent:15 https://doi.org/10.1515/hsz-2012-0186 Deutschlandweit zugänglich GBV_USEFLAG_U ZDB-1-DGR GBV_NL_ARTICLE AR 393 2012 12 13 11 1433-1447 15 |
allfields_unstemmed |
10.1515/hsz-2012-0186 doi artikel_Grundlieferung.pp (DE-627)NLEJ246932066 DE-627 ger DE-627 rakwb Dissecting the impact of Frizzled receptors in Wnt/β-catenin signaling of human mesenchymal stem cells De Gruyter 2012 15 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Wnt/β-catenin signaling is of fundamental importance in the regulation of self-renewal, migration/invasion, and differentiation of human mesenchymal stem cells (hMSCs). Because little information is available about the function of Frizzled receptors (Fzds) as the main receptors of Wnt proteins in hMSCs, we first performed comparative Fzd mRNA expression profiling. Fzd9 and Fzd10 were not expressed in hMSCs. While Fzd3 was expressed at low levels in hMSCs, the other Fzds exhibited high expression rates. Activation and repression of Wnt signaling in hMSCs revealed that the expression levels of Fzd1, Fzd6, and Fzd7 are positively correlated with the Wnt/β-catenin activation status, whereas Fzd8 exhibited an inverse relation. For studying the functional relevance of Fzds in Wnt/β-catenin signaling, RNA interference, ectopic expression studies, and rescue approaches were performed in hMSCs carrying a highly sensitive TCF/LEF reporter gene system (Gaussia luciferase). We found that, Fzd1, Fzd5, Fzd7, and Fzd8 are largely involved in Wnt/β-catenin signaling of hMSCs. Moreover, the knockdown of Fzd5 can be compensated by the ectopic expression of Fzd7. Conversely, the ectopic expression of Fzd5 in Fzd7-knockdown hMSCs resulted in a rescue of Wnt/β-catenin signaling, pointing to a functional redundancy of Fzd5 and Fzd7. Walter de Gruyter Online Zeitschriften Frizzled receptors (Fzds) human mesenchymal stem cells (hMSCs) RNA interference TCF/LEF reporter gene system Wnt/β-catenin signaling Kolben, Thomas oth Peröbner, Iris oth Fernsebner, Katharina oth Lechner, Felix oth Geissler, Claudia oth Ruiz-Heinrich, Lourdes oth Capovilla, Simon oth Jochum, Marianne oth Neth, Peter oth Enthalten in Biological chemistry Berlin [u.a.] : de Gruyter, 1996 393(2012), 12 vom: 13. Nov., Seite 1433-1447 (DE-627)NLEJ248235095 (DE-600)1466062-3 1437-4315 nnns volume:393 year:2012 number:12 day:13 month:11 pages:1433-1447 extent:15 https://doi.org/10.1515/hsz-2012-0186 Deutschlandweit zugänglich GBV_USEFLAG_U ZDB-1-DGR GBV_NL_ARTICLE AR 393 2012 12 13 11 1433-1447 15 |
allfieldsGer |
10.1515/hsz-2012-0186 doi artikel_Grundlieferung.pp (DE-627)NLEJ246932066 DE-627 ger DE-627 rakwb Dissecting the impact of Frizzled receptors in Wnt/β-catenin signaling of human mesenchymal stem cells De Gruyter 2012 15 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Wnt/β-catenin signaling is of fundamental importance in the regulation of self-renewal, migration/invasion, and differentiation of human mesenchymal stem cells (hMSCs). Because little information is available about the function of Frizzled receptors (Fzds) as the main receptors of Wnt proteins in hMSCs, we first performed comparative Fzd mRNA expression profiling. Fzd9 and Fzd10 were not expressed in hMSCs. While Fzd3 was expressed at low levels in hMSCs, the other Fzds exhibited high expression rates. Activation and repression of Wnt signaling in hMSCs revealed that the expression levels of Fzd1, Fzd6, and Fzd7 are positively correlated with the Wnt/β-catenin activation status, whereas Fzd8 exhibited an inverse relation. For studying the functional relevance of Fzds in Wnt/β-catenin signaling, RNA interference, ectopic expression studies, and rescue approaches were performed in hMSCs carrying a highly sensitive TCF/LEF reporter gene system (Gaussia luciferase). We found that, Fzd1, Fzd5, Fzd7, and Fzd8 are largely involved in Wnt/β-catenin signaling of hMSCs. Moreover, the knockdown of Fzd5 can be compensated by the ectopic expression of Fzd7. Conversely, the ectopic expression of Fzd5 in Fzd7-knockdown hMSCs resulted in a rescue of Wnt/β-catenin signaling, pointing to a functional redundancy of Fzd5 and Fzd7. Walter de Gruyter Online Zeitschriften Frizzled receptors (Fzds) human mesenchymal stem cells (hMSCs) RNA interference TCF/LEF reporter gene system Wnt/β-catenin signaling Kolben, Thomas oth Peröbner, Iris oth Fernsebner, Katharina oth Lechner, Felix oth Geissler, Claudia oth Ruiz-Heinrich, Lourdes oth Capovilla, Simon oth Jochum, Marianne oth Neth, Peter oth Enthalten in Biological chemistry Berlin [u.a.] : de Gruyter, 1996 393(2012), 12 vom: 13. Nov., Seite 1433-1447 (DE-627)NLEJ248235095 (DE-600)1466062-3 1437-4315 nnns volume:393 year:2012 number:12 day:13 month:11 pages:1433-1447 extent:15 https://doi.org/10.1515/hsz-2012-0186 Deutschlandweit zugänglich GBV_USEFLAG_U ZDB-1-DGR GBV_NL_ARTICLE AR 393 2012 12 13 11 1433-1447 15 |
allfieldsSound |
10.1515/hsz-2012-0186 doi artikel_Grundlieferung.pp (DE-627)NLEJ246932066 DE-627 ger DE-627 rakwb Dissecting the impact of Frizzled receptors in Wnt/β-catenin signaling of human mesenchymal stem cells De Gruyter 2012 15 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Wnt/β-catenin signaling is of fundamental importance in the regulation of self-renewal, migration/invasion, and differentiation of human mesenchymal stem cells (hMSCs). Because little information is available about the function of Frizzled receptors (Fzds) as the main receptors of Wnt proteins in hMSCs, we first performed comparative Fzd mRNA expression profiling. Fzd9 and Fzd10 were not expressed in hMSCs. While Fzd3 was expressed at low levels in hMSCs, the other Fzds exhibited high expression rates. Activation and repression of Wnt signaling in hMSCs revealed that the expression levels of Fzd1, Fzd6, and Fzd7 are positively correlated with the Wnt/β-catenin activation status, whereas Fzd8 exhibited an inverse relation. For studying the functional relevance of Fzds in Wnt/β-catenin signaling, RNA interference, ectopic expression studies, and rescue approaches were performed in hMSCs carrying a highly sensitive TCF/LEF reporter gene system (Gaussia luciferase). We found that, Fzd1, Fzd5, Fzd7, and Fzd8 are largely involved in Wnt/β-catenin signaling of hMSCs. Moreover, the knockdown of Fzd5 can be compensated by the ectopic expression of Fzd7. Conversely, the ectopic expression of Fzd5 in Fzd7-knockdown hMSCs resulted in a rescue of Wnt/β-catenin signaling, pointing to a functional redundancy of Fzd5 and Fzd7. Walter de Gruyter Online Zeitschriften Frizzled receptors (Fzds) human mesenchymal stem cells (hMSCs) RNA interference TCF/LEF reporter gene system Wnt/β-catenin signaling Kolben, Thomas oth Peröbner, Iris oth Fernsebner, Katharina oth Lechner, Felix oth Geissler, Claudia oth Ruiz-Heinrich, Lourdes oth Capovilla, Simon oth Jochum, Marianne oth Neth, Peter oth Enthalten in Biological chemistry Berlin [u.a.] : de Gruyter, 1996 393(2012), 12 vom: 13. Nov., Seite 1433-1447 (DE-627)NLEJ248235095 (DE-600)1466062-3 1437-4315 nnns volume:393 year:2012 number:12 day:13 month:11 pages:1433-1447 extent:15 https://doi.org/10.1515/hsz-2012-0186 Deutschlandweit zugänglich GBV_USEFLAG_U ZDB-1-DGR GBV_NL_ARTICLE AR 393 2012 12 13 11 1433-1447 15 |
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Dissecting the impact of Frizzled receptors in Wnt/β-catenin signaling of human mesenchymal stem cells |
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title_full |
Dissecting the impact of Frizzled receptors in Wnt/β-catenin signaling of human mesenchymal stem cells |
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Biological chemistry |
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2012 |
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doi_str_mv |
10.1515/hsz-2012-0186 |
title_sort |
dissecting the impact of frizzled receptors in wnt/β-catenin signaling of human mesenchymal stem cells |
title_auth |
Dissecting the impact of Frizzled receptors in Wnt/β-catenin signaling of human mesenchymal stem cells |
abstract |
Wnt/β-catenin signaling is of fundamental importance in the regulation of self-renewal, migration/invasion, and differentiation of human mesenchymal stem cells (hMSCs). Because little information is available about the function of Frizzled receptors (Fzds) as the main receptors of Wnt proteins in hMSCs, we first performed comparative Fzd mRNA expression profiling. Fzd9 and Fzd10 were not expressed in hMSCs. While Fzd3 was expressed at low levels in hMSCs, the other Fzds exhibited high expression rates. Activation and repression of Wnt signaling in hMSCs revealed that the expression levels of Fzd1, Fzd6, and Fzd7 are positively correlated with the Wnt/β-catenin activation status, whereas Fzd8 exhibited an inverse relation. For studying the functional relevance of Fzds in Wnt/β-catenin signaling, RNA interference, ectopic expression studies, and rescue approaches were performed in hMSCs carrying a highly sensitive TCF/LEF reporter gene system (Gaussia luciferase). We found that, Fzd1, Fzd5, Fzd7, and Fzd8 are largely involved in Wnt/β-catenin signaling of hMSCs. Moreover, the knockdown of Fzd5 can be compensated by the ectopic expression of Fzd7. Conversely, the ectopic expression of Fzd5 in Fzd7-knockdown hMSCs resulted in a rescue of Wnt/β-catenin signaling, pointing to a functional redundancy of Fzd5 and Fzd7. |
abstractGer |
Wnt/β-catenin signaling is of fundamental importance in the regulation of self-renewal, migration/invasion, and differentiation of human mesenchymal stem cells (hMSCs). Because little information is available about the function of Frizzled receptors (Fzds) as the main receptors of Wnt proteins in hMSCs, we first performed comparative Fzd mRNA expression profiling. Fzd9 and Fzd10 were not expressed in hMSCs. While Fzd3 was expressed at low levels in hMSCs, the other Fzds exhibited high expression rates. Activation and repression of Wnt signaling in hMSCs revealed that the expression levels of Fzd1, Fzd6, and Fzd7 are positively correlated with the Wnt/β-catenin activation status, whereas Fzd8 exhibited an inverse relation. For studying the functional relevance of Fzds in Wnt/β-catenin signaling, RNA interference, ectopic expression studies, and rescue approaches were performed in hMSCs carrying a highly sensitive TCF/LEF reporter gene system (Gaussia luciferase). We found that, Fzd1, Fzd5, Fzd7, and Fzd8 are largely involved in Wnt/β-catenin signaling of hMSCs. Moreover, the knockdown of Fzd5 can be compensated by the ectopic expression of Fzd7. Conversely, the ectopic expression of Fzd5 in Fzd7-knockdown hMSCs resulted in a rescue of Wnt/β-catenin signaling, pointing to a functional redundancy of Fzd5 and Fzd7. |
abstract_unstemmed |
Wnt/β-catenin signaling is of fundamental importance in the regulation of self-renewal, migration/invasion, and differentiation of human mesenchymal stem cells (hMSCs). Because little information is available about the function of Frizzled receptors (Fzds) as the main receptors of Wnt proteins in hMSCs, we first performed comparative Fzd mRNA expression profiling. Fzd9 and Fzd10 were not expressed in hMSCs. While Fzd3 was expressed at low levels in hMSCs, the other Fzds exhibited high expression rates. Activation and repression of Wnt signaling in hMSCs revealed that the expression levels of Fzd1, Fzd6, and Fzd7 are positively correlated with the Wnt/β-catenin activation status, whereas Fzd8 exhibited an inverse relation. For studying the functional relevance of Fzds in Wnt/β-catenin signaling, RNA interference, ectopic expression studies, and rescue approaches were performed in hMSCs carrying a highly sensitive TCF/LEF reporter gene system (Gaussia luciferase). We found that, Fzd1, Fzd5, Fzd7, and Fzd8 are largely involved in Wnt/β-catenin signaling of hMSCs. Moreover, the knockdown of Fzd5 can be compensated by the ectopic expression of Fzd7. Conversely, the ectopic expression of Fzd5 in Fzd7-knockdown hMSCs resulted in a rescue of Wnt/β-catenin signaling, pointing to a functional redundancy of Fzd5 and Fzd7. |
collection_details |
GBV_USEFLAG_U ZDB-1-DGR GBV_NL_ARTICLE |
container_issue |
12 |
title_short |
Dissecting the impact of Frizzled receptors in Wnt/β-catenin signaling of human mesenchymal stem cells |
url |
https://doi.org/10.1515/hsz-2012-0186 |
remote_bool |
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author2 |
Kolben, Thomas Peröbner, Iris Fernsebner, Katharina Lechner, Felix Geissler, Claudia Ruiz-Heinrich, Lourdes Capovilla, Simon Jochum, Marianne Neth, Peter |
author2Str |
Kolben, Thomas Peröbner, Iris Fernsebner, Katharina Lechner, Felix Geissler, Claudia Ruiz-Heinrich, Lourdes Capovilla, Simon Jochum, Marianne Neth, Peter |
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up_date |
2024-07-06T09:37:46.649Z |
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