What is the effect of ghrelin on rat uterine contractility in vitro?
Background: Ghrelin, a recently isolated gastric hormone, is an endogenous ligand for growth hormone secretagogue receptors. There is novel evidence that ghrelin might be expressed in rat ovaries, placental tissues, and the uterus. It has been reported to have modulatory effects on smooth muscle con...
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| Autor*in: |
Mostafa, Abeer F. [verfasserIn] Samir, Shereen M. [verfasserIn] |
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| Format: |
E-Artikel |
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| Erschienen: |
De Gruyter ; 2013 |
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| Schlagwörter: |
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| Umfang: |
6 |
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| Reproduktion: |
Walter de Gruyter Online Zeitschriften |
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| Übergeordnetes Werk: |
Enthalten in: Journal of basic and clinical physiology and pharmacology - Berlin : de Gruyter, 1990, 24(2013), 2 vom: 25. Feb., Seite 137-142 |
| Übergeordnetes Werk: |
volume:24 ; year:2013 ; number:2 ; day:25 ; month:02 ; pages:137-142 ; extent:6 |
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| DOI / URN: |
10.1515/jbcpp-2012-0063 |
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NLEJ247070041 |
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| 520 | |a Background: Ghrelin, a recently isolated gastric hormone, is an endogenous ligand for growth hormone secretagogue receptors. There is novel evidence that ghrelin might be expressed in rat ovaries, placental tissues, and the uterus. It has been reported to have modulatory effects on smooth muscle contractility. In this study, we investigated the effects of ghrelin on spontaneous and oxytocin-induced contractions in the rat uterus in vitro and tried to detect its signaling pathway. Methods: Myometrium strips were removed from virgin female albino Wister rats and placed in a jacketed tissue bath. After initiation of spontaneous contractions, ghrelin was added to the tissue bath alone or after administration of indomethacin or NG-nitro-L-arginine methyl ester (L-NAME) or propranolol HCl. Student’s t-test was used for statistical analysis. Results: Our results revealed an inhibitory effect of ghrelin on both spontaneous and oxytocin-induced myometrial contractions. This effect was not affected by the application of indomethacin or L-NAME but was blocked after propranolol HCl administration. Conclusions: Ghrelin has an inhibitory effect on basal and oxytocin-induced rat myometrial contractions in vitro, and this myometrial response to ghrelin might be mediated by β-receptor signaling pathway. | ||
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10.1515/jbcpp-2012-0063 doi artikel_Grundlieferung.pp (DE-627)NLEJ247070041 DE-627 ger DE-627 rakwb Mostafa, Abeer F. verfasserin aut What is the effect of ghrelin on rat uterine contractility in vitro? De Gruyter 2013 6 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Background: Ghrelin, a recently isolated gastric hormone, is an endogenous ligand for growth hormone secretagogue receptors. There is novel evidence that ghrelin might be expressed in rat ovaries, placental tissues, and the uterus. It has been reported to have modulatory effects on smooth muscle contractility. In this study, we investigated the effects of ghrelin on spontaneous and oxytocin-induced contractions in the rat uterus in vitro and tried to detect its signaling pathway. Methods: Myometrium strips were removed from virgin female albino Wister rats and placed in a jacketed tissue bath. After initiation of spontaneous contractions, ghrelin was added to the tissue bath alone or after administration of indomethacin or NG-nitro-L-arginine methyl ester (L-NAME) or propranolol HCl. Student’s t-test was used for statistical analysis. Results: Our results revealed an inhibitory effect of ghrelin on both spontaneous and oxytocin-induced myometrial contractions. This effect was not affected by the application of indomethacin or L-NAME but was blocked after propranolol HCl administration. Conclusions: Ghrelin has an inhibitory effect on basal and oxytocin-induced rat myometrial contractions in vitro, and this myometrial response to ghrelin might be mediated by β-receptor signaling pathway. Walter de Gruyter Online Zeitschriften ghrelin indomethacin L-NAME myometrium propranolol HCl Samir, Shereen M. verfasserin aut Enthalten in Journal of basic and clinical physiology and pharmacology Berlin : de Gruyter, 1990 24(2013), 2 vom: 25. Feb., Seite 137-142 (DE-627)NLEJ248235974 (DE-600)2602428-7 2191-0286 nnns volume:24 year:2013 number:2 day:25 month:02 pages:137-142 extent:6 https://doi.org/10.1515/jbcpp-2012-0063 Deutschlandweit zugänglich GBV_USEFLAG_U ZDB-1-DGR GBV_NL_ARTICLE AR 24 2013 2 25 02 137-142 6 |
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10.1515/jbcpp-2012-0063 doi artikel_Grundlieferung.pp (DE-627)NLEJ247070041 DE-627 ger DE-627 rakwb Mostafa, Abeer F. verfasserin aut What is the effect of ghrelin on rat uterine contractility in vitro? De Gruyter 2013 6 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Background: Ghrelin, a recently isolated gastric hormone, is an endogenous ligand for growth hormone secretagogue receptors. There is novel evidence that ghrelin might be expressed in rat ovaries, placental tissues, and the uterus. It has been reported to have modulatory effects on smooth muscle contractility. In this study, we investigated the effects of ghrelin on spontaneous and oxytocin-induced contractions in the rat uterus in vitro and tried to detect its signaling pathway. Methods: Myometrium strips were removed from virgin female albino Wister rats and placed in a jacketed tissue bath. After initiation of spontaneous contractions, ghrelin was added to the tissue bath alone or after administration of indomethacin or NG-nitro-L-arginine methyl ester (L-NAME) or propranolol HCl. Student’s t-test was used for statistical analysis. Results: Our results revealed an inhibitory effect of ghrelin on both spontaneous and oxytocin-induced myometrial contractions. This effect was not affected by the application of indomethacin or L-NAME but was blocked after propranolol HCl administration. Conclusions: Ghrelin has an inhibitory effect on basal and oxytocin-induced rat myometrial contractions in vitro, and this myometrial response to ghrelin might be mediated by β-receptor signaling pathway. Walter de Gruyter Online Zeitschriften ghrelin indomethacin L-NAME myometrium propranolol HCl Samir, Shereen M. verfasserin aut Enthalten in Journal of basic and clinical physiology and pharmacology Berlin : de Gruyter, 1990 24(2013), 2 vom: 25. Feb., Seite 137-142 (DE-627)NLEJ248235974 (DE-600)2602428-7 2191-0286 nnns volume:24 year:2013 number:2 day:25 month:02 pages:137-142 extent:6 https://doi.org/10.1515/jbcpp-2012-0063 Deutschlandweit zugänglich GBV_USEFLAG_U ZDB-1-DGR GBV_NL_ARTICLE AR 24 2013 2 25 02 137-142 6 |
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10.1515/jbcpp-2012-0063 doi artikel_Grundlieferung.pp (DE-627)NLEJ247070041 DE-627 ger DE-627 rakwb Mostafa, Abeer F. verfasserin aut What is the effect of ghrelin on rat uterine contractility in vitro? De Gruyter 2013 6 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Background: Ghrelin, a recently isolated gastric hormone, is an endogenous ligand for growth hormone secretagogue receptors. There is novel evidence that ghrelin might be expressed in rat ovaries, placental tissues, and the uterus. It has been reported to have modulatory effects on smooth muscle contractility. In this study, we investigated the effects of ghrelin on spontaneous and oxytocin-induced contractions in the rat uterus in vitro and tried to detect its signaling pathway. Methods: Myometrium strips were removed from virgin female albino Wister rats and placed in a jacketed tissue bath. After initiation of spontaneous contractions, ghrelin was added to the tissue bath alone or after administration of indomethacin or NG-nitro-L-arginine methyl ester (L-NAME) or propranolol HCl. Student’s t-test was used for statistical analysis. Results: Our results revealed an inhibitory effect of ghrelin on both spontaneous and oxytocin-induced myometrial contractions. This effect was not affected by the application of indomethacin or L-NAME but was blocked after propranolol HCl administration. Conclusions: Ghrelin has an inhibitory effect on basal and oxytocin-induced rat myometrial contractions in vitro, and this myometrial response to ghrelin might be mediated by β-receptor signaling pathway. Walter de Gruyter Online Zeitschriften ghrelin indomethacin L-NAME myometrium propranolol HCl Samir, Shereen M. verfasserin aut Enthalten in Journal of basic and clinical physiology and pharmacology Berlin : de Gruyter, 1990 24(2013), 2 vom: 25. Feb., Seite 137-142 (DE-627)NLEJ248235974 (DE-600)2602428-7 2191-0286 nnns volume:24 year:2013 number:2 day:25 month:02 pages:137-142 extent:6 https://doi.org/10.1515/jbcpp-2012-0063 Deutschlandweit zugänglich GBV_USEFLAG_U ZDB-1-DGR GBV_NL_ARTICLE AR 24 2013 2 25 02 137-142 6 |
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10.1515/jbcpp-2012-0063 doi artikel_Grundlieferung.pp (DE-627)NLEJ247070041 DE-627 ger DE-627 rakwb Mostafa, Abeer F. verfasserin aut What is the effect of ghrelin on rat uterine contractility in vitro? De Gruyter 2013 6 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Background: Ghrelin, a recently isolated gastric hormone, is an endogenous ligand for growth hormone secretagogue receptors. There is novel evidence that ghrelin might be expressed in rat ovaries, placental tissues, and the uterus. It has been reported to have modulatory effects on smooth muscle contractility. In this study, we investigated the effects of ghrelin on spontaneous and oxytocin-induced contractions in the rat uterus in vitro and tried to detect its signaling pathway. Methods: Myometrium strips were removed from virgin female albino Wister rats and placed in a jacketed tissue bath. After initiation of spontaneous contractions, ghrelin was added to the tissue bath alone or after administration of indomethacin or NG-nitro-L-arginine methyl ester (L-NAME) or propranolol HCl. Student’s t-test was used for statistical analysis. Results: Our results revealed an inhibitory effect of ghrelin on both spontaneous and oxytocin-induced myometrial contractions. This effect was not affected by the application of indomethacin or L-NAME but was blocked after propranolol HCl administration. Conclusions: Ghrelin has an inhibitory effect on basal and oxytocin-induced rat myometrial contractions in vitro, and this myometrial response to ghrelin might be mediated by β-receptor signaling pathway. Walter de Gruyter Online Zeitschriften ghrelin indomethacin L-NAME myometrium propranolol HCl Samir, Shereen M. verfasserin aut Enthalten in Journal of basic and clinical physiology and pharmacology Berlin : de Gruyter, 1990 24(2013), 2 vom: 25. Feb., Seite 137-142 (DE-627)NLEJ248235974 (DE-600)2602428-7 2191-0286 nnns volume:24 year:2013 number:2 day:25 month:02 pages:137-142 extent:6 https://doi.org/10.1515/jbcpp-2012-0063 Deutschlandweit zugänglich GBV_USEFLAG_U ZDB-1-DGR GBV_NL_ARTICLE AR 24 2013 2 25 02 137-142 6 |
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10.1515/jbcpp-2012-0063 doi artikel_Grundlieferung.pp (DE-627)NLEJ247070041 DE-627 ger DE-627 rakwb Mostafa, Abeer F. verfasserin aut What is the effect of ghrelin on rat uterine contractility in vitro? De Gruyter 2013 6 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Background: Ghrelin, a recently isolated gastric hormone, is an endogenous ligand for growth hormone secretagogue receptors. There is novel evidence that ghrelin might be expressed in rat ovaries, placental tissues, and the uterus. It has been reported to have modulatory effects on smooth muscle contractility. In this study, we investigated the effects of ghrelin on spontaneous and oxytocin-induced contractions in the rat uterus in vitro and tried to detect its signaling pathway. Methods: Myometrium strips were removed from virgin female albino Wister rats and placed in a jacketed tissue bath. After initiation of spontaneous contractions, ghrelin was added to the tissue bath alone or after administration of indomethacin or NG-nitro-L-arginine methyl ester (L-NAME) or propranolol HCl. Student’s t-test was used for statistical analysis. Results: Our results revealed an inhibitory effect of ghrelin on both spontaneous and oxytocin-induced myometrial contractions. This effect was not affected by the application of indomethacin or L-NAME but was blocked after propranolol HCl administration. Conclusions: Ghrelin has an inhibitory effect on basal and oxytocin-induced rat myometrial contractions in vitro, and this myometrial response to ghrelin might be mediated by β-receptor signaling pathway. Walter de Gruyter Online Zeitschriften ghrelin indomethacin L-NAME myometrium propranolol HCl Samir, Shereen M. verfasserin aut Enthalten in Journal of basic and clinical physiology and pharmacology Berlin : de Gruyter, 1990 24(2013), 2 vom: 25. Feb., Seite 137-142 (DE-627)NLEJ248235974 (DE-600)2602428-7 2191-0286 nnns volume:24 year:2013 number:2 day:25 month:02 pages:137-142 extent:6 https://doi.org/10.1515/jbcpp-2012-0063 Deutschlandweit zugänglich GBV_USEFLAG_U ZDB-1-DGR GBV_NL_ARTICLE AR 24 2013 2 25 02 137-142 6 |
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Background: Ghrelin, a recently isolated gastric hormone, is an endogenous ligand for growth hormone secretagogue receptors. There is novel evidence that ghrelin might be expressed in rat ovaries, placental tissues, and the uterus. It has been reported to have modulatory effects on smooth muscle contractility. In this study, we investigated the effects of ghrelin on spontaneous and oxytocin-induced contractions in the rat uterus in vitro and tried to detect its signaling pathway. Methods: Myometrium strips were removed from virgin female albino Wister rats and placed in a jacketed tissue bath. After initiation of spontaneous contractions, ghrelin was added to the tissue bath alone or after administration of indomethacin or NG-nitro-L-arginine methyl ester (L-NAME) or propranolol HCl. Student’s t-test was used for statistical analysis. Results: Our results revealed an inhibitory effect of ghrelin on both spontaneous and oxytocin-induced myometrial contractions. This effect was not affected by the application of indomethacin or L-NAME but was blocked after propranolol HCl administration. Conclusions: Ghrelin has an inhibitory effect on basal and oxytocin-induced rat myometrial contractions in vitro, and this myometrial response to ghrelin might be mediated by β-receptor signaling pathway. |
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Background: Ghrelin, a recently isolated gastric hormone, is an endogenous ligand for growth hormone secretagogue receptors. There is novel evidence that ghrelin might be expressed in rat ovaries, placental tissues, and the uterus. It has been reported to have modulatory effects on smooth muscle contractility. In this study, we investigated the effects of ghrelin on spontaneous and oxytocin-induced contractions in the rat uterus in vitro and tried to detect its signaling pathway. Methods: Myometrium strips were removed from virgin female albino Wister rats and placed in a jacketed tissue bath. After initiation of spontaneous contractions, ghrelin was added to the tissue bath alone or after administration of indomethacin or NG-nitro-L-arginine methyl ester (L-NAME) or propranolol HCl. Student’s t-test was used for statistical analysis. Results: Our results revealed an inhibitory effect of ghrelin on both spontaneous and oxytocin-induced myometrial contractions. This effect was not affected by the application of indomethacin or L-NAME but was blocked after propranolol HCl administration. Conclusions: Ghrelin has an inhibitory effect on basal and oxytocin-induced rat myometrial contractions in vitro, and this myometrial response to ghrelin might be mediated by β-receptor signaling pathway. |
| abstract_unstemmed |
Background: Ghrelin, a recently isolated gastric hormone, is an endogenous ligand for growth hormone secretagogue receptors. There is novel evidence that ghrelin might be expressed in rat ovaries, placental tissues, and the uterus. It has been reported to have modulatory effects on smooth muscle contractility. In this study, we investigated the effects of ghrelin on spontaneous and oxytocin-induced contractions in the rat uterus in vitro and tried to detect its signaling pathway. Methods: Myometrium strips were removed from virgin female albino Wister rats and placed in a jacketed tissue bath. After initiation of spontaneous contractions, ghrelin was added to the tissue bath alone or after administration of indomethacin or NG-nitro-L-arginine methyl ester (L-NAME) or propranolol HCl. Student’s t-test was used for statistical analysis. Results: Our results revealed an inhibitory effect of ghrelin on both spontaneous and oxytocin-induced myometrial contractions. This effect was not affected by the application of indomethacin or L-NAME but was blocked after propranolol HCl administration. Conclusions: Ghrelin has an inhibitory effect on basal and oxytocin-induced rat myometrial contractions in vitro, and this myometrial response to ghrelin might be mediated by β-receptor signaling pathway. |
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