Current normal values for TSH and FT3 in children are too low: evidence from over 11,000 samples
Background: Current pediatric normal values for thyroid function tests are based on data from relatively few patients. Objective: To develop new normal pediatric values based on a large sample of children. Patients and methods: Data were collected from a computerized database in Jerusalem, Israel, o...
Ausführliche Beschreibung
Gespeichert in:
| Autor*in: |
Strich, David [verfasserIn] Edri, Shalom [verfasserIn] Gillis, David [verfasserIn] |
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| Format: |
E-Artikel |
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| Erschienen: |
Walter de Gruyter ; 2012 |
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| Schlagwörter: |
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| Anmerkung: |
©2012 by Walter de Gruyter Berlin Boston |
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| Umfang: |
4 |
| Reproduktion: |
Walter de Gruyter Online Zeitschriften |
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| Übergeordnetes Werk: |
Enthalten in: The journal of pediatric endocrinology and metabolism - Berlin [u.a.] : de Gruyter, 1985, 25(2012), 3-4 vom: 16. März, Seite 245-248 |
| Übergeordnetes Werk: |
volume:25 ; year:2012 ; number:3-4 ; day:16 ; month:03 ; pages:245-248 ; extent:4 |
| Links: |
|---|
| DOI / URN: |
10.1515/jpem-2011-0494 |
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NLEJ247119938 |
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| 520 | |a Background: Current pediatric normal values for thyroid function tests are based on data from relatively few patients. Objective: To develop new normal pediatric values based on a large sample of children. Patients and methods: Data were collected from a computerized database in Jerusalem, Israel, of thyroid function tests taken in community pediatric clinics. Samples from patients with antithyroid peroxidase antibodies and/or antithyroglobulin antibodies and from those treated with levothyroxine, methimazole, propylthiouracil, thyrotropin, lithium, phenobarbital, or glucocorticoids were excluded. The analysis included over 11,000 samples tested for TSH, free triiodothyronine (FT3), and free thyroxine (FT4) with the ADVIA® Centaur™ system. Results: The upper normal limit (UNL) for TSH increased by about 1 mIU/L and the lower normal limit (LNL) for FT3 increased by 0.5–2 pmol/L in different age groups. There was no significant change in FT4 values. Conclusions: These reference data should replace current normal values. | ||
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10.1515/jpem-2011-0494 doi artikel_Grundlieferung.pp (DE-627)NLEJ247119938 DE-627 ger DE-627 rakwb Strich, David verfasserin aut Current normal values for TSH and FT3 in children are too low: evidence from over 11,000 samples Walter de Gruyter 2012 4 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier ©2012 by Walter de Gruyter Berlin Boston Background: Current pediatric normal values for thyroid function tests are based on data from relatively few patients. Objective: To develop new normal pediatric values based on a large sample of children. Patients and methods: Data were collected from a computerized database in Jerusalem, Israel, of thyroid function tests taken in community pediatric clinics. Samples from patients with antithyroid peroxidase antibodies and/or antithyroglobulin antibodies and from those treated with levothyroxine, methimazole, propylthiouracil, thyrotropin, lithium, phenobarbital, or glucocorticoids were excluded. The analysis included over 11,000 samples tested for TSH, free triiodothyronine (FT3), and free thyroxine (FT4) with the ADVIA® Centaur™ system. Results: The upper normal limit (UNL) for TSH increased by about 1 mIU/L and the lower normal limit (LNL) for FT3 increased by 0.5–2 pmol/L in different age groups. There was no significant change in FT4 values. Conclusions: These reference data should replace current normal values. Walter de Gruyter Online Zeitschriften normal values thyroid Edri, Shalom verfasserin aut Gillis, David verfasserin aut Enthalten in The journal of pediatric endocrinology and metabolism Berlin [u.a.] : de Gruyter, 1985 25(2012), 3-4 vom: 16. März, Seite 245-248 (DE-627)NLEJ248236202 (DE-600)2583847-7 2191-0251 nnns volume:25 year:2012 number:3-4 day:16 month:03 pages:245-248 extent:4 https://doi.org/10.1515/jpem-2011-0494 Deutschlandweit zugänglich GBV_USEFLAG_U ZDB-1-DGR GBV_NL_ARTICLE AR 25 2012 3-4 16 03 245-248 4 |
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10.1515/jpem-2011-0494 doi artikel_Grundlieferung.pp (DE-627)NLEJ247119938 DE-627 ger DE-627 rakwb Strich, David verfasserin aut Current normal values for TSH and FT3 in children are too low: evidence from over 11,000 samples Walter de Gruyter 2012 4 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier ©2012 by Walter de Gruyter Berlin Boston Background: Current pediatric normal values for thyroid function tests are based on data from relatively few patients. Objective: To develop new normal pediatric values based on a large sample of children. Patients and methods: Data were collected from a computerized database in Jerusalem, Israel, of thyroid function tests taken in community pediatric clinics. Samples from patients with antithyroid peroxidase antibodies and/or antithyroglobulin antibodies and from those treated with levothyroxine, methimazole, propylthiouracil, thyrotropin, lithium, phenobarbital, or glucocorticoids were excluded. The analysis included over 11,000 samples tested for TSH, free triiodothyronine (FT3), and free thyroxine (FT4) with the ADVIA® Centaur™ system. Results: The upper normal limit (UNL) for TSH increased by about 1 mIU/L and the lower normal limit (LNL) for FT3 increased by 0.5–2 pmol/L in different age groups. There was no significant change in FT4 values. Conclusions: These reference data should replace current normal values. Walter de Gruyter Online Zeitschriften normal values thyroid Edri, Shalom verfasserin aut Gillis, David verfasserin aut Enthalten in The journal of pediatric endocrinology and metabolism Berlin [u.a.] : de Gruyter, 1985 25(2012), 3-4 vom: 16. März, Seite 245-248 (DE-627)NLEJ248236202 (DE-600)2583847-7 2191-0251 nnns volume:25 year:2012 number:3-4 day:16 month:03 pages:245-248 extent:4 https://doi.org/10.1515/jpem-2011-0494 Deutschlandweit zugänglich GBV_USEFLAG_U ZDB-1-DGR GBV_NL_ARTICLE AR 25 2012 3-4 16 03 245-248 4 |
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10.1515/jpem-2011-0494 doi artikel_Grundlieferung.pp (DE-627)NLEJ247119938 DE-627 ger DE-627 rakwb Strich, David verfasserin aut Current normal values for TSH and FT3 in children are too low: evidence from over 11,000 samples Walter de Gruyter 2012 4 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier ©2012 by Walter de Gruyter Berlin Boston Background: Current pediatric normal values for thyroid function tests are based on data from relatively few patients. Objective: To develop new normal pediatric values based on a large sample of children. Patients and methods: Data were collected from a computerized database in Jerusalem, Israel, of thyroid function tests taken in community pediatric clinics. Samples from patients with antithyroid peroxidase antibodies and/or antithyroglobulin antibodies and from those treated with levothyroxine, methimazole, propylthiouracil, thyrotropin, lithium, phenobarbital, or glucocorticoids were excluded. The analysis included over 11,000 samples tested for TSH, free triiodothyronine (FT3), and free thyroxine (FT4) with the ADVIA® Centaur™ system. Results: The upper normal limit (UNL) for TSH increased by about 1 mIU/L and the lower normal limit (LNL) for FT3 increased by 0.5–2 pmol/L in different age groups. There was no significant change in FT4 values. Conclusions: These reference data should replace current normal values. Walter de Gruyter Online Zeitschriften normal values thyroid Edri, Shalom verfasserin aut Gillis, David verfasserin aut Enthalten in The journal of pediatric endocrinology and metabolism Berlin [u.a.] : de Gruyter, 1985 25(2012), 3-4 vom: 16. März, Seite 245-248 (DE-627)NLEJ248236202 (DE-600)2583847-7 2191-0251 nnns volume:25 year:2012 number:3-4 day:16 month:03 pages:245-248 extent:4 https://doi.org/10.1515/jpem-2011-0494 Deutschlandweit zugänglich GBV_USEFLAG_U ZDB-1-DGR GBV_NL_ARTICLE AR 25 2012 3-4 16 03 245-248 4 |
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10.1515/jpem-2011-0494 doi artikel_Grundlieferung.pp (DE-627)NLEJ247119938 DE-627 ger DE-627 rakwb Strich, David verfasserin aut Current normal values for TSH and FT3 in children are too low: evidence from over 11,000 samples Walter de Gruyter 2012 4 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier ©2012 by Walter de Gruyter Berlin Boston Background: Current pediatric normal values for thyroid function tests are based on data from relatively few patients. Objective: To develop new normal pediatric values based on a large sample of children. Patients and methods: Data were collected from a computerized database in Jerusalem, Israel, of thyroid function tests taken in community pediatric clinics. Samples from patients with antithyroid peroxidase antibodies and/or antithyroglobulin antibodies and from those treated with levothyroxine, methimazole, propylthiouracil, thyrotropin, lithium, phenobarbital, or glucocorticoids were excluded. The analysis included over 11,000 samples tested for TSH, free triiodothyronine (FT3), and free thyroxine (FT4) with the ADVIA® Centaur™ system. Results: The upper normal limit (UNL) for TSH increased by about 1 mIU/L and the lower normal limit (LNL) for FT3 increased by 0.5–2 pmol/L in different age groups. There was no significant change in FT4 values. Conclusions: These reference data should replace current normal values. Walter de Gruyter Online Zeitschriften normal values thyroid Edri, Shalom verfasserin aut Gillis, David verfasserin aut Enthalten in The journal of pediatric endocrinology and metabolism Berlin [u.a.] : de Gruyter, 1985 25(2012), 3-4 vom: 16. März, Seite 245-248 (DE-627)NLEJ248236202 (DE-600)2583847-7 2191-0251 nnns volume:25 year:2012 number:3-4 day:16 month:03 pages:245-248 extent:4 https://doi.org/10.1515/jpem-2011-0494 Deutschlandweit zugänglich GBV_USEFLAG_U ZDB-1-DGR GBV_NL_ARTICLE AR 25 2012 3-4 16 03 245-248 4 |
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10.1515/jpem-2011-0494 doi artikel_Grundlieferung.pp (DE-627)NLEJ247119938 DE-627 ger DE-627 rakwb Strich, David verfasserin aut Current normal values for TSH and FT3 in children are too low: evidence from over 11,000 samples Walter de Gruyter 2012 4 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier ©2012 by Walter de Gruyter Berlin Boston Background: Current pediatric normal values for thyroid function tests are based on data from relatively few patients. Objective: To develop new normal pediatric values based on a large sample of children. Patients and methods: Data were collected from a computerized database in Jerusalem, Israel, of thyroid function tests taken in community pediatric clinics. Samples from patients with antithyroid peroxidase antibodies and/or antithyroglobulin antibodies and from those treated with levothyroxine, methimazole, propylthiouracil, thyrotropin, lithium, phenobarbital, or glucocorticoids were excluded. The analysis included over 11,000 samples tested for TSH, free triiodothyronine (FT3), and free thyroxine (FT4) with the ADVIA® Centaur™ system. Results: The upper normal limit (UNL) for TSH increased by about 1 mIU/L and the lower normal limit (LNL) for FT3 increased by 0.5–2 pmol/L in different age groups. There was no significant change in FT4 values. Conclusions: These reference data should replace current normal values. Walter de Gruyter Online Zeitschriften normal values thyroid Edri, Shalom verfasserin aut Gillis, David verfasserin aut Enthalten in The journal of pediatric endocrinology and metabolism Berlin [u.a.] : de Gruyter, 1985 25(2012), 3-4 vom: 16. März, Seite 245-248 (DE-627)NLEJ248236202 (DE-600)2583847-7 2191-0251 nnns volume:25 year:2012 number:3-4 day:16 month:03 pages:245-248 extent:4 https://doi.org/10.1515/jpem-2011-0494 Deutschlandweit zugänglich GBV_USEFLAG_U ZDB-1-DGR GBV_NL_ARTICLE AR 25 2012 3-4 16 03 245-248 4 |
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Current normal values for TSH and FT3 in children are too low: evidence from over 11,000 samples |
| abstract |
Background: Current pediatric normal values for thyroid function tests are based on data from relatively few patients. Objective: To develop new normal pediatric values based on a large sample of children. Patients and methods: Data were collected from a computerized database in Jerusalem, Israel, of thyroid function tests taken in community pediatric clinics. Samples from patients with antithyroid peroxidase antibodies and/or antithyroglobulin antibodies and from those treated with levothyroxine, methimazole, propylthiouracil, thyrotropin, lithium, phenobarbital, or glucocorticoids were excluded. The analysis included over 11,000 samples tested for TSH, free triiodothyronine (FT3), and free thyroxine (FT4) with the ADVIA® Centaur™ system. Results: The upper normal limit (UNL) for TSH increased by about 1 mIU/L and the lower normal limit (LNL) for FT3 increased by 0.5–2 pmol/L in different age groups. There was no significant change in FT4 values. Conclusions: These reference data should replace current normal values. ©2012 by Walter de Gruyter Berlin Boston |
| abstractGer |
Background: Current pediatric normal values for thyroid function tests are based on data from relatively few patients. Objective: To develop new normal pediatric values based on a large sample of children. Patients and methods: Data were collected from a computerized database in Jerusalem, Israel, of thyroid function tests taken in community pediatric clinics. Samples from patients with antithyroid peroxidase antibodies and/or antithyroglobulin antibodies and from those treated with levothyroxine, methimazole, propylthiouracil, thyrotropin, lithium, phenobarbital, or glucocorticoids were excluded. The analysis included over 11,000 samples tested for TSH, free triiodothyronine (FT3), and free thyroxine (FT4) with the ADVIA® Centaur™ system. Results: The upper normal limit (UNL) for TSH increased by about 1 mIU/L and the lower normal limit (LNL) for FT3 increased by 0.5–2 pmol/L in different age groups. There was no significant change in FT4 values. Conclusions: These reference data should replace current normal values. ©2012 by Walter de Gruyter Berlin Boston |
| abstract_unstemmed |
Background: Current pediatric normal values for thyroid function tests are based on data from relatively few patients. Objective: To develop new normal pediatric values based on a large sample of children. Patients and methods: Data were collected from a computerized database in Jerusalem, Israel, of thyroid function tests taken in community pediatric clinics. Samples from patients with antithyroid peroxidase antibodies and/or antithyroglobulin antibodies and from those treated with levothyroxine, methimazole, propylthiouracil, thyrotropin, lithium, phenobarbital, or glucocorticoids were excluded. The analysis included over 11,000 samples tested for TSH, free triiodothyronine (FT3), and free thyroxine (FT4) with the ADVIA® Centaur™ system. Results: The upper normal limit (UNL) for TSH increased by about 1 mIU/L and the lower normal limit (LNL) for FT3 increased by 0.5–2 pmol/L in different age groups. There was no significant change in FT4 values. Conclusions: These reference data should replace current normal values. ©2012 by Walter de Gruyter Berlin Boston |
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NLEJ248236202 |
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| doi_str |
10.1515/jpem-2011-0494 |
| up_date |
2024-07-06T09:59:37.756Z |
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1803823326436524032 |
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<?xml version="1.0" encoding="UTF-8"?><collection xmlns="http://www.loc.gov/MARC21/slim"><record><leader>01000caa a22002652 4500</leader><controlfield tag="001">NLEJ247119938</controlfield><controlfield tag="003">DE-627</controlfield><controlfield tag="005">20220820030419.0</controlfield><controlfield tag="007">cr uuu---uuuuu</controlfield><controlfield tag="008">220814s2012 xx |||||o 00| ||und c</controlfield><datafield tag="024" ind1="7" ind2=" "><subfield code="a">10.1515/jpem-2011-0494</subfield><subfield code="2">doi</subfield></datafield><datafield tag="028" ind1="5" ind2="2"><subfield code="a">artikel_Grundlieferung.pp</subfield></datafield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(DE-627)NLEJ247119938</subfield></datafield><datafield tag="040" ind1=" " ind2=" "><subfield code="a">DE-627</subfield><subfield code="b">ger</subfield><subfield code="c">DE-627</subfield><subfield code="e">rakwb</subfield></datafield><datafield tag="100" ind1="1" ind2=" "><subfield code="a">Strich, David</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="245" ind1="1" ind2="0"><subfield code="a">Current normal values for TSH and FT3 in children are too low: evidence from over 11,000 samples</subfield></datafield><datafield tag="264" ind1=" " ind2="1"><subfield code="b">Walter de Gruyter</subfield><subfield code="c">2012</subfield></datafield><datafield tag="300" ind1=" " ind2=" "><subfield code="a">4</subfield></datafield><datafield tag="336" ind1=" " ind2=" "><subfield code="a">Text</subfield><subfield code="b">txt</subfield><subfield code="2">rdacontent</subfield></datafield><datafield tag="337" ind1=" " ind2=" "><subfield code="a">Computermedien</subfield><subfield code="b">c</subfield><subfield code="2">rdamedia</subfield></datafield><datafield tag="338" ind1=" " ind2=" "><subfield code="a">Online-Ressource</subfield><subfield code="b">cr</subfield><subfield code="2">rdacarrier</subfield></datafield><datafield tag="500" ind1=" " ind2=" "><subfield code="a">©2012 by Walter de Gruyter Berlin Boston</subfield></datafield><datafield tag="520" ind1=" " ind2=" "><subfield code="a">Background: Current pediatric normal values for thyroid function tests are based on data from relatively few patients. Objective: To develop new normal pediatric values based on a large sample of children. Patients and methods: Data were collected from a computerized database in Jerusalem, Israel, of thyroid function tests taken in community pediatric clinics. Samples from patients with antithyroid peroxidase antibodies and/or antithyroglobulin antibodies and from those treated with levothyroxine, methimazole, propylthiouracil, thyrotropin, lithium, phenobarbital, or glucocorticoids were excluded. The analysis included over 11,000 samples tested for TSH, free triiodothyronine (FT3), and free thyroxine (FT4) with the ADVIA® Centaur™ system. Results: The upper normal limit (UNL) for TSH increased by about 1 mIU/L and the lower normal limit (LNL) for FT3 increased by 0.5–2 pmol/L in different age groups. There was no significant change in FT4 values. 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März, Seite 245-248</subfield><subfield code="w">(DE-627)NLEJ248236202</subfield><subfield code="w">(DE-600)2583847-7</subfield><subfield code="x">2191-0251</subfield><subfield code="7">nnns</subfield></datafield><datafield tag="773" ind1="1" ind2="8"><subfield code="g">volume:25</subfield><subfield code="g">year:2012</subfield><subfield code="g">number:3-4</subfield><subfield code="g">day:16</subfield><subfield code="g">month:03</subfield><subfield code="g">pages:245-248</subfield><subfield code="g">extent:4</subfield></datafield><datafield tag="856" ind1="4" ind2="0"><subfield code="u">https://doi.org/10.1515/jpem-2011-0494</subfield><subfield code="z">Deutschlandweit zugänglich</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_USEFLAG_U</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">ZDB-1-DGR</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_NL_ARTICLE</subfield></datafield><datafield tag="951" ind1=" " ind2=" "><subfield code="a">AR</subfield></datafield><datafield tag="952" ind1=" " ind2=" "><subfield code="d">25</subfield><subfield code="j">2012</subfield><subfield code="e">3-4</subfield><subfield code="b">16</subfield><subfield code="c">03</subfield><subfield code="h">245-248</subfield><subfield code="g">4</subfield></datafield></record></collection>
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7.400403 |