Development of antibodies against growth hormone (GH) during rhGH therapy in a girl with idiopathic GH deficiency: a case report
A 12.5-year-old Italian girl was referred to our institute for progressive growth failure from the age of 6 years, with a height of 128.2 cm (–3.37 SDS) and a bone age of 9 years. Endocrinological evaluation revealed a partial growth hormone deficiency (GHD) and GH therapy was started at a dosage of...
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De Gruyter ; 2013 |
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4 |
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Walter de Gruyter Online Zeitschriften |
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Enthalten in: The journal of pediatric endocrinology and metabolism - Berlin [u.a.] : de Gruyter, 1985, 26(2013), 7-8 vom: 02. Apr., Seite 785-788 |
| Übergeordnetes Werk: |
volume:26 ; year:2013 ; number:7-8 ; day:02 ; month:04 ; pages:785-788 ; extent:4 |
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10.1515/jpem-2013-0064 |
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NLEJ247123161 |
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| 520 | |a A 12.5-year-old Italian girl was referred to our institute for progressive growth failure from the age of 6 years, with a height of 128.2 cm (–3.37 SDS) and a bone age of 9 years. Endocrinological evaluation revealed a partial growth hormone deficiency (GHD) and GH therapy was started at a dosage of 0.25 mg/kg/week. During the first 3 years, she showed an increase in growth rate and experienced pubertal development onset. Then a poor growth rate (2 cm/year=0.43 SDS) was observed, notwithstanding an increase in GH dosage (0.35 mg/kg/week) and good compliance. We found a positive anti-GH antibody titre (1:1850, cutoff 1/100), confirmed 6 months later (1:2035); the antibodies had low binding capacity (0.63 μg/mL) and were only partially capable of inhibiting the GH effect. However, GH treatment was discontinued, and after 3 months the antibody titre decreased (1:950). In conclusion, we suggest evaluation of anti-GH antibodies in GH-treated idiopathic GHD children in whom growth response decreases after some years of therapy. | ||
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| 700 | 1 | |a Pagani, Sara |4 oth | |
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| 700 | 1 | |a Bozzola, Elena |4 oth | |
| 700 | 1 | |a Kratzsch, Juergen |4 oth | |
| 700 | 1 | |a Bozzola, Mauro |4 oth | |
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10.1515/jpem-2013-0064 doi artikel_Grundlieferung.pp (DE-627)NLEJ247123161 DE-627 ger DE-627 rakwb Development of antibodies against growth hormone (GH) during rhGH therapy in a girl with idiopathic GH deficiency: a case report De Gruyter 2013 4 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier A 12.5-year-old Italian girl was referred to our institute for progressive growth failure from the age of 6 years, with a height of 128.2 cm (–3.37 SDS) and a bone age of 9 years. Endocrinological evaluation revealed a partial growth hormone deficiency (GHD) and GH therapy was started at a dosage of 0.25 mg/kg/week. During the first 3 years, she showed an increase in growth rate and experienced pubertal development onset. Then a poor growth rate (2 cm/year=0.43 SDS) was observed, notwithstanding an increase in GH dosage (0.35 mg/kg/week) and good compliance. We found a positive anti-GH antibody titre (1:1850, cutoff 1/100), confirmed 6 months later (1:2035); the antibodies had low binding capacity (0.63 μg/mL) and were only partially capable of inhibiting the GH effect. However, GH treatment was discontinued, and after 3 months the antibody titre decreased (1:950). In conclusion, we suggest evaluation of anti-GH antibodies in GH-treated idiopathic GHD children in whom growth response decreases after some years of therapy. Walter de Gruyter Online Zeitschriften anti-GH antibodies growth hormone (GH) deficiency growth hormone (GH) therapy Meazza, Cristina oth Schaab, Michael oth Pagani, Sara oth Calcaterra, Valeria oth Bozzola, Elena oth Kratzsch, Juergen oth Bozzola, Mauro oth Enthalten in The journal of pediatric endocrinology and metabolism Berlin [u.a.] : de Gruyter, 1985 26(2013), 7-8 vom: 02. Apr., Seite 785-788 (DE-627)NLEJ248236202 (DE-600)2583847-7 2191-0251 nnns volume:26 year:2013 number:7-8 day:02 month:04 pages:785-788 extent:4 https://doi.org/10.1515/jpem-2013-0064 Deutschlandweit zugänglich GBV_USEFLAG_U ZDB-1-DGR GBV_NL_ARTICLE AR 26 2013 7-8 02 04 785-788 4 |
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10.1515/jpem-2013-0064 doi artikel_Grundlieferung.pp (DE-627)NLEJ247123161 DE-627 ger DE-627 rakwb Development of antibodies against growth hormone (GH) during rhGH therapy in a girl with idiopathic GH deficiency: a case report De Gruyter 2013 4 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier A 12.5-year-old Italian girl was referred to our institute for progressive growth failure from the age of 6 years, with a height of 128.2 cm (–3.37 SDS) and a bone age of 9 years. Endocrinological evaluation revealed a partial growth hormone deficiency (GHD) and GH therapy was started at a dosage of 0.25 mg/kg/week. During the first 3 years, she showed an increase in growth rate and experienced pubertal development onset. Then a poor growth rate (2 cm/year=0.43 SDS) was observed, notwithstanding an increase in GH dosage (0.35 mg/kg/week) and good compliance. We found a positive anti-GH antibody titre (1:1850, cutoff 1/100), confirmed 6 months later (1:2035); the antibodies had low binding capacity (0.63 μg/mL) and were only partially capable of inhibiting the GH effect. However, GH treatment was discontinued, and after 3 months the antibody titre decreased (1:950). In conclusion, we suggest evaluation of anti-GH antibodies in GH-treated idiopathic GHD children in whom growth response decreases after some years of therapy. Walter de Gruyter Online Zeitschriften anti-GH antibodies growth hormone (GH) deficiency growth hormone (GH) therapy Meazza, Cristina oth Schaab, Michael oth Pagani, Sara oth Calcaterra, Valeria oth Bozzola, Elena oth Kratzsch, Juergen oth Bozzola, Mauro oth Enthalten in The journal of pediatric endocrinology and metabolism Berlin [u.a.] : de Gruyter, 1985 26(2013), 7-8 vom: 02. Apr., Seite 785-788 (DE-627)NLEJ248236202 (DE-600)2583847-7 2191-0251 nnns volume:26 year:2013 number:7-8 day:02 month:04 pages:785-788 extent:4 https://doi.org/10.1515/jpem-2013-0064 Deutschlandweit zugänglich GBV_USEFLAG_U ZDB-1-DGR GBV_NL_ARTICLE AR 26 2013 7-8 02 04 785-788 4 |
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10.1515/jpem-2013-0064 doi artikel_Grundlieferung.pp (DE-627)NLEJ247123161 DE-627 ger DE-627 rakwb Development of antibodies against growth hormone (GH) during rhGH therapy in a girl with idiopathic GH deficiency: a case report De Gruyter 2013 4 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier A 12.5-year-old Italian girl was referred to our institute for progressive growth failure from the age of 6 years, with a height of 128.2 cm (–3.37 SDS) and a bone age of 9 years. Endocrinological evaluation revealed a partial growth hormone deficiency (GHD) and GH therapy was started at a dosage of 0.25 mg/kg/week. During the first 3 years, she showed an increase in growth rate and experienced pubertal development onset. Then a poor growth rate (2 cm/year=0.43 SDS) was observed, notwithstanding an increase in GH dosage (0.35 mg/kg/week) and good compliance. We found a positive anti-GH antibody titre (1:1850, cutoff 1/100), confirmed 6 months later (1:2035); the antibodies had low binding capacity (0.63 μg/mL) and were only partially capable of inhibiting the GH effect. However, GH treatment was discontinued, and after 3 months the antibody titre decreased (1:950). In conclusion, we suggest evaluation of anti-GH antibodies in GH-treated idiopathic GHD children in whom growth response decreases after some years of therapy. Walter de Gruyter Online Zeitschriften anti-GH antibodies growth hormone (GH) deficiency growth hormone (GH) therapy Meazza, Cristina oth Schaab, Michael oth Pagani, Sara oth Calcaterra, Valeria oth Bozzola, Elena oth Kratzsch, Juergen oth Bozzola, Mauro oth Enthalten in The journal of pediatric endocrinology and metabolism Berlin [u.a.] : de Gruyter, 1985 26(2013), 7-8 vom: 02. Apr., Seite 785-788 (DE-627)NLEJ248236202 (DE-600)2583847-7 2191-0251 nnns volume:26 year:2013 number:7-8 day:02 month:04 pages:785-788 extent:4 https://doi.org/10.1515/jpem-2013-0064 Deutschlandweit zugänglich GBV_USEFLAG_U ZDB-1-DGR GBV_NL_ARTICLE AR 26 2013 7-8 02 04 785-788 4 |
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10.1515/jpem-2013-0064 doi artikel_Grundlieferung.pp (DE-627)NLEJ247123161 DE-627 ger DE-627 rakwb Development of antibodies against growth hormone (GH) during rhGH therapy in a girl with idiopathic GH deficiency: a case report De Gruyter 2013 4 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier A 12.5-year-old Italian girl was referred to our institute for progressive growth failure from the age of 6 years, with a height of 128.2 cm (–3.37 SDS) and a bone age of 9 years. Endocrinological evaluation revealed a partial growth hormone deficiency (GHD) and GH therapy was started at a dosage of 0.25 mg/kg/week. During the first 3 years, she showed an increase in growth rate and experienced pubertal development onset. Then a poor growth rate (2 cm/year=0.43 SDS) was observed, notwithstanding an increase in GH dosage (0.35 mg/kg/week) and good compliance. We found a positive anti-GH antibody titre (1:1850, cutoff 1/100), confirmed 6 months later (1:2035); the antibodies had low binding capacity (0.63 μg/mL) and were only partially capable of inhibiting the GH effect. However, GH treatment was discontinued, and after 3 months the antibody titre decreased (1:950). In conclusion, we suggest evaluation of anti-GH antibodies in GH-treated idiopathic GHD children in whom growth response decreases after some years of therapy. Walter de Gruyter Online Zeitschriften anti-GH antibodies growth hormone (GH) deficiency growth hormone (GH) therapy Meazza, Cristina oth Schaab, Michael oth Pagani, Sara oth Calcaterra, Valeria oth Bozzola, Elena oth Kratzsch, Juergen oth Bozzola, Mauro oth Enthalten in The journal of pediatric endocrinology and metabolism Berlin [u.a.] : de Gruyter, 1985 26(2013), 7-8 vom: 02. Apr., Seite 785-788 (DE-627)NLEJ248236202 (DE-600)2583847-7 2191-0251 nnns volume:26 year:2013 number:7-8 day:02 month:04 pages:785-788 extent:4 https://doi.org/10.1515/jpem-2013-0064 Deutschlandweit zugänglich GBV_USEFLAG_U ZDB-1-DGR GBV_NL_ARTICLE AR 26 2013 7-8 02 04 785-788 4 |
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10.1515/jpem-2013-0064 doi artikel_Grundlieferung.pp (DE-627)NLEJ247123161 DE-627 ger DE-627 rakwb Development of antibodies against growth hormone (GH) during rhGH therapy in a girl with idiopathic GH deficiency: a case report De Gruyter 2013 4 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier A 12.5-year-old Italian girl was referred to our institute for progressive growth failure from the age of 6 years, with a height of 128.2 cm (–3.37 SDS) and a bone age of 9 years. Endocrinological evaluation revealed a partial growth hormone deficiency (GHD) and GH therapy was started at a dosage of 0.25 mg/kg/week. During the first 3 years, she showed an increase in growth rate and experienced pubertal development onset. Then a poor growth rate (2 cm/year=0.43 SDS) was observed, notwithstanding an increase in GH dosage (0.35 mg/kg/week) and good compliance. We found a positive anti-GH antibody titre (1:1850, cutoff 1/100), confirmed 6 months later (1:2035); the antibodies had low binding capacity (0.63 μg/mL) and were only partially capable of inhibiting the GH effect. However, GH treatment was discontinued, and after 3 months the antibody titre decreased (1:950). In conclusion, we suggest evaluation of anti-GH antibodies in GH-treated idiopathic GHD children in whom growth response decreases after some years of therapy. Walter de Gruyter Online Zeitschriften anti-GH antibodies growth hormone (GH) deficiency growth hormone (GH) therapy Meazza, Cristina oth Schaab, Michael oth Pagani, Sara oth Calcaterra, Valeria oth Bozzola, Elena oth Kratzsch, Juergen oth Bozzola, Mauro oth Enthalten in The journal of pediatric endocrinology and metabolism Berlin [u.a.] : de Gruyter, 1985 26(2013), 7-8 vom: 02. Apr., Seite 785-788 (DE-627)NLEJ248236202 (DE-600)2583847-7 2191-0251 nnns volume:26 year:2013 number:7-8 day:02 month:04 pages:785-788 extent:4 https://doi.org/10.1515/jpem-2013-0064 Deutschlandweit zugänglich GBV_USEFLAG_U ZDB-1-DGR GBV_NL_ARTICLE AR 26 2013 7-8 02 04 785-788 4 |
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development of antibodies against growth hormone (gh) during rhgh therapy in a girl with idiopathic gh deficiency: a case report |
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Development of antibodies against growth hormone (GH) during rhGH therapy in a girl with idiopathic GH deficiency: a case report |
| abstract |
A 12.5-year-old Italian girl was referred to our institute for progressive growth failure from the age of 6 years, with a height of 128.2 cm (–3.37 SDS) and a bone age of 9 years. Endocrinological evaluation revealed a partial growth hormone deficiency (GHD) and GH therapy was started at a dosage of 0.25 mg/kg/week. During the first 3 years, she showed an increase in growth rate and experienced pubertal development onset. Then a poor growth rate (2 cm/year=0.43 SDS) was observed, notwithstanding an increase in GH dosage (0.35 mg/kg/week) and good compliance. We found a positive anti-GH antibody titre (1:1850, cutoff 1/100), confirmed 6 months later (1:2035); the antibodies had low binding capacity (0.63 μg/mL) and were only partially capable of inhibiting the GH effect. However, GH treatment was discontinued, and after 3 months the antibody titre decreased (1:950). In conclusion, we suggest evaluation of anti-GH antibodies in GH-treated idiopathic GHD children in whom growth response decreases after some years of therapy. |
| abstractGer |
A 12.5-year-old Italian girl was referred to our institute for progressive growth failure from the age of 6 years, with a height of 128.2 cm (–3.37 SDS) and a bone age of 9 years. Endocrinological evaluation revealed a partial growth hormone deficiency (GHD) and GH therapy was started at a dosage of 0.25 mg/kg/week. During the first 3 years, she showed an increase in growth rate and experienced pubertal development onset. Then a poor growth rate (2 cm/year=0.43 SDS) was observed, notwithstanding an increase in GH dosage (0.35 mg/kg/week) and good compliance. We found a positive anti-GH antibody titre (1:1850, cutoff 1/100), confirmed 6 months later (1:2035); the antibodies had low binding capacity (0.63 μg/mL) and were only partially capable of inhibiting the GH effect. However, GH treatment was discontinued, and after 3 months the antibody titre decreased (1:950). In conclusion, we suggest evaluation of anti-GH antibodies in GH-treated idiopathic GHD children in whom growth response decreases after some years of therapy. |
| abstract_unstemmed |
A 12.5-year-old Italian girl was referred to our institute for progressive growth failure from the age of 6 years, with a height of 128.2 cm (–3.37 SDS) and a bone age of 9 years. Endocrinological evaluation revealed a partial growth hormone deficiency (GHD) and GH therapy was started at a dosage of 0.25 mg/kg/week. During the first 3 years, she showed an increase in growth rate and experienced pubertal development onset. Then a poor growth rate (2 cm/year=0.43 SDS) was observed, notwithstanding an increase in GH dosage (0.35 mg/kg/week) and good compliance. We found a positive anti-GH antibody titre (1:1850, cutoff 1/100), confirmed 6 months later (1:2035); the antibodies had low binding capacity (0.63 μg/mL) and were only partially capable of inhibiting the GH effect. However, GH treatment was discontinued, and after 3 months the antibody titre decreased (1:950). In conclusion, we suggest evaluation of anti-GH antibodies in GH-treated idiopathic GHD children in whom growth response decreases after some years of therapy. |
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Meazza, Cristina Schaab, Michael Pagani, Sara Calcaterra, Valeria Bozzola, Elena Kratzsch, Juergen Bozzola, Mauro |
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Meazza, Cristina Schaab, Michael Pagani, Sara Calcaterra, Valeria Bozzola, Elena Kratzsch, Juergen Bozzola, Mauro |
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