Growth Hormone Response to GH-Releasing Peptide-2 in Children
The insulin tolerance test (ITT) has been considered the most reliable test in the diagnosis of growth hormone deficiency (GHD), but it is contraindicated in some patients. Recently, the use of GH-Releasing Peptide-2 (GHRP-2) has been validated and reported as a safe and reliable test for the diagno...
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E-Artikel |
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| Erschienen: |
Walter de Gruyter GmbH & Co. KG ; 2010 |
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© Freund Publishing House Ltd. 2010 |
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| Umfang: |
8 |
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Walter de Gruyter Online Zeitschriften |
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Enthalten in: The journal of pediatric endocrinology and metabolism - Berlin [u.a.] : de Gruyter, 1985, 23(2010), 5 vom: 17. Sept., Seite 473-480 |
| Übergeordnetes Werk: |
volume:23 ; year:2010 ; number:5 ; day:17 ; month:09 ; pages:473-480 ; extent:8 |
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10.1515/jpem.2010.078 |
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| 520 | |a The insulin tolerance test (ITT) has been considered the most reliable test in the diagnosis of growth hormone deficiency (GHD), but it is contraindicated in some patients. Recently, the use of GH-Releasing Peptide-2 (GHRP-2) has been validated and reported as a safe and reliable test for the diagnosis of adult severe GHD. We evaluated the GH response to GHRP-2 in 56 children with growth disorders to assess its efficacy. A dose of 2 μg/kg of GHRP-2 was administered intravenously and serum GH concentrations were determined. The Spearman correlation coefficient for GH peak values indicated a favorable correlation with the ITT (P<0.0001). Peak GH concentrations were significantly (p<0.0001) lower in children with (median:3.39 μg/l (ng/ml)) than without (25.10 μg/l (ng/ml)) GHD. In the analysis of sensitivity-specificity curves, the serum concentration at the point where sensitivity crosses specificity was 15 μg/l (ng/ml). The GHRP-2 test was safe and required only one hour or less, and was capable of diagnosing GHD in children. | ||
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10.1515/jpem.2010.078 doi artikel_Grundlieferung.pp (DE-627)NLEJ247127574 DE-627 ger DE-627 rakwb Growth Hormone Response to GH-Releasing Peptide-2 in Children Walter de Gruyter GmbH & Co. KG 2010 8 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Freund Publishing House Ltd. 2010 The insulin tolerance test (ITT) has been considered the most reliable test in the diagnosis of growth hormone deficiency (GHD), but it is contraindicated in some patients. Recently, the use of GH-Releasing Peptide-2 (GHRP-2) has been validated and reported as a safe and reliable test for the diagnosis of adult severe GHD. We evaluated the GH response to GHRP-2 in 56 children with growth disorders to assess its efficacy. A dose of 2 μg/kg of GHRP-2 was administered intravenously and serum GH concentrations were determined. The Spearman correlation coefficient for GH peak values indicated a favorable correlation with the ITT (P<0.0001). Peak GH concentrations were significantly (p<0.0001) lower in children with (median:3.39 μg/l (ng/ml)) than without (25.10 μg/l (ng/ml)) GHD. In the analysis of sensitivity-specificity curves, the serum concentration at the point where sensitivity crosses specificity was 15 μg/l (ng/ml). The GHRP-2 test was safe and required only one hour or less, and was capable of diagnosing GHD in children. Walter de Gruyter Online Zeitschriften GH secretagogue GH-releasing peptide-2 growth hormone deficiency children Asakura, Yumi oth Toyota, Yuko oth Muroya, Koji oth Adachi, Masanori oth Enthalten in The journal of pediatric endocrinology and metabolism Berlin [u.a.] : de Gruyter, 1985 23(2010), 5 vom: 17. Sept., Seite 473-480 (DE-627)NLEJ248236202 (DE-600)2583847-7 2191-0251 nnns volume:23 year:2010 number:5 day:17 month:09 pages:473-480 extent:8 https://doi.org/10.1515/jpem.2010.078 Deutschlandweit zugänglich GBV_USEFLAG_U ZDB-1-DGR GBV_NL_ARTICLE AR 23 2010 5 17 09 473-480 8 |
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10.1515/jpem.2010.078 doi artikel_Grundlieferung.pp (DE-627)NLEJ247127574 DE-627 ger DE-627 rakwb Growth Hormone Response to GH-Releasing Peptide-2 in Children Walter de Gruyter GmbH & Co. KG 2010 8 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Freund Publishing House Ltd. 2010 The insulin tolerance test (ITT) has been considered the most reliable test in the diagnosis of growth hormone deficiency (GHD), but it is contraindicated in some patients. Recently, the use of GH-Releasing Peptide-2 (GHRP-2) has been validated and reported as a safe and reliable test for the diagnosis of adult severe GHD. We evaluated the GH response to GHRP-2 in 56 children with growth disorders to assess its efficacy. A dose of 2 μg/kg of GHRP-2 was administered intravenously and serum GH concentrations were determined. The Spearman correlation coefficient for GH peak values indicated a favorable correlation with the ITT (P<0.0001). Peak GH concentrations were significantly (p<0.0001) lower in children with (median:3.39 μg/l (ng/ml)) than without (25.10 μg/l (ng/ml)) GHD. In the analysis of sensitivity-specificity curves, the serum concentration at the point where sensitivity crosses specificity was 15 μg/l (ng/ml). The GHRP-2 test was safe and required only one hour or less, and was capable of diagnosing GHD in children. Walter de Gruyter Online Zeitschriften GH secretagogue GH-releasing peptide-2 growth hormone deficiency children Asakura, Yumi oth Toyota, Yuko oth Muroya, Koji oth Adachi, Masanori oth Enthalten in The journal of pediatric endocrinology and metabolism Berlin [u.a.] : de Gruyter, 1985 23(2010), 5 vom: 17. Sept., Seite 473-480 (DE-627)NLEJ248236202 (DE-600)2583847-7 2191-0251 nnns volume:23 year:2010 number:5 day:17 month:09 pages:473-480 extent:8 https://doi.org/10.1515/jpem.2010.078 Deutschlandweit zugänglich GBV_USEFLAG_U ZDB-1-DGR GBV_NL_ARTICLE AR 23 2010 5 17 09 473-480 8 |
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10.1515/jpem.2010.078 doi artikel_Grundlieferung.pp (DE-627)NLEJ247127574 DE-627 ger DE-627 rakwb Growth Hormone Response to GH-Releasing Peptide-2 in Children Walter de Gruyter GmbH & Co. KG 2010 8 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Freund Publishing House Ltd. 2010 The insulin tolerance test (ITT) has been considered the most reliable test in the diagnosis of growth hormone deficiency (GHD), but it is contraindicated in some patients. Recently, the use of GH-Releasing Peptide-2 (GHRP-2) has been validated and reported as a safe and reliable test for the diagnosis of adult severe GHD. We evaluated the GH response to GHRP-2 in 56 children with growth disorders to assess its efficacy. A dose of 2 μg/kg of GHRP-2 was administered intravenously and serum GH concentrations were determined. The Spearman correlation coefficient for GH peak values indicated a favorable correlation with the ITT (P<0.0001). Peak GH concentrations were significantly (p<0.0001) lower in children with (median:3.39 μg/l (ng/ml)) than without (25.10 μg/l (ng/ml)) GHD. In the analysis of sensitivity-specificity curves, the serum concentration at the point where sensitivity crosses specificity was 15 μg/l (ng/ml). The GHRP-2 test was safe and required only one hour or less, and was capable of diagnosing GHD in children. Walter de Gruyter Online Zeitschriften GH secretagogue GH-releasing peptide-2 growth hormone deficiency children Asakura, Yumi oth Toyota, Yuko oth Muroya, Koji oth Adachi, Masanori oth Enthalten in The journal of pediatric endocrinology and metabolism Berlin [u.a.] : de Gruyter, 1985 23(2010), 5 vom: 17. Sept., Seite 473-480 (DE-627)NLEJ248236202 (DE-600)2583847-7 2191-0251 nnns volume:23 year:2010 number:5 day:17 month:09 pages:473-480 extent:8 https://doi.org/10.1515/jpem.2010.078 Deutschlandweit zugänglich GBV_USEFLAG_U ZDB-1-DGR GBV_NL_ARTICLE AR 23 2010 5 17 09 473-480 8 |
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10.1515/jpem.2010.078 doi artikel_Grundlieferung.pp (DE-627)NLEJ247127574 DE-627 ger DE-627 rakwb Growth Hormone Response to GH-Releasing Peptide-2 in Children Walter de Gruyter GmbH & Co. KG 2010 8 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Freund Publishing House Ltd. 2010 The insulin tolerance test (ITT) has been considered the most reliable test in the diagnosis of growth hormone deficiency (GHD), but it is contraindicated in some patients. Recently, the use of GH-Releasing Peptide-2 (GHRP-2) has been validated and reported as a safe and reliable test for the diagnosis of adult severe GHD. We evaluated the GH response to GHRP-2 in 56 children with growth disorders to assess its efficacy. A dose of 2 μg/kg of GHRP-2 was administered intravenously and serum GH concentrations were determined. The Spearman correlation coefficient for GH peak values indicated a favorable correlation with the ITT (P<0.0001). Peak GH concentrations were significantly (p<0.0001) lower in children with (median:3.39 μg/l (ng/ml)) than without (25.10 μg/l (ng/ml)) GHD. In the analysis of sensitivity-specificity curves, the serum concentration at the point where sensitivity crosses specificity was 15 μg/l (ng/ml). The GHRP-2 test was safe and required only one hour or less, and was capable of diagnosing GHD in children. Walter de Gruyter Online Zeitschriften GH secretagogue GH-releasing peptide-2 growth hormone deficiency children Asakura, Yumi oth Toyota, Yuko oth Muroya, Koji oth Adachi, Masanori oth Enthalten in The journal of pediatric endocrinology and metabolism Berlin [u.a.] : de Gruyter, 1985 23(2010), 5 vom: 17. Sept., Seite 473-480 (DE-627)NLEJ248236202 (DE-600)2583847-7 2191-0251 nnns volume:23 year:2010 number:5 day:17 month:09 pages:473-480 extent:8 https://doi.org/10.1515/jpem.2010.078 Deutschlandweit zugänglich GBV_USEFLAG_U ZDB-1-DGR GBV_NL_ARTICLE AR 23 2010 5 17 09 473-480 8 |
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10.1515/jpem.2010.078 doi artikel_Grundlieferung.pp (DE-627)NLEJ247127574 DE-627 ger DE-627 rakwb Growth Hormone Response to GH-Releasing Peptide-2 in Children Walter de Gruyter GmbH & Co. KG 2010 8 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Freund Publishing House Ltd. 2010 The insulin tolerance test (ITT) has been considered the most reliable test in the diagnosis of growth hormone deficiency (GHD), but it is contraindicated in some patients. Recently, the use of GH-Releasing Peptide-2 (GHRP-2) has been validated and reported as a safe and reliable test for the diagnosis of adult severe GHD. We evaluated the GH response to GHRP-2 in 56 children with growth disorders to assess its efficacy. A dose of 2 μg/kg of GHRP-2 was administered intravenously and serum GH concentrations were determined. The Spearman correlation coefficient for GH peak values indicated a favorable correlation with the ITT (P<0.0001). Peak GH concentrations were significantly (p<0.0001) lower in children with (median:3.39 μg/l (ng/ml)) than without (25.10 μg/l (ng/ml)) GHD. In the analysis of sensitivity-specificity curves, the serum concentration at the point where sensitivity crosses specificity was 15 μg/l (ng/ml). The GHRP-2 test was safe and required only one hour or less, and was capable of diagnosing GHD in children. Walter de Gruyter Online Zeitschriften GH secretagogue GH-releasing peptide-2 growth hormone deficiency children Asakura, Yumi oth Toyota, Yuko oth Muroya, Koji oth Adachi, Masanori oth Enthalten in The journal of pediatric endocrinology and metabolism Berlin [u.a.] : de Gruyter, 1985 23(2010), 5 vom: 17. Sept., Seite 473-480 (DE-627)NLEJ248236202 (DE-600)2583847-7 2191-0251 nnns volume:23 year:2010 number:5 day:17 month:09 pages:473-480 extent:8 https://doi.org/10.1515/jpem.2010.078 Deutschlandweit zugänglich GBV_USEFLAG_U ZDB-1-DGR GBV_NL_ARTICLE AR 23 2010 5 17 09 473-480 8 |
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Growth Hormone Response to GH-Releasing Peptide-2 in Children |
| abstract |
The insulin tolerance test (ITT) has been considered the most reliable test in the diagnosis of growth hormone deficiency (GHD), but it is contraindicated in some patients. Recently, the use of GH-Releasing Peptide-2 (GHRP-2) has been validated and reported as a safe and reliable test for the diagnosis of adult severe GHD. We evaluated the GH response to GHRP-2 in 56 children with growth disorders to assess its efficacy. A dose of 2 μg/kg of GHRP-2 was administered intravenously and serum GH concentrations were determined. The Spearman correlation coefficient for GH peak values indicated a favorable correlation with the ITT (P<0.0001). Peak GH concentrations were significantly (p<0.0001) lower in children with (median:3.39 μg/l (ng/ml)) than without (25.10 μg/l (ng/ml)) GHD. In the analysis of sensitivity-specificity curves, the serum concentration at the point where sensitivity crosses specificity was 15 μg/l (ng/ml). The GHRP-2 test was safe and required only one hour or less, and was capable of diagnosing GHD in children. © Freund Publishing House Ltd. 2010 |
| abstractGer |
The insulin tolerance test (ITT) has been considered the most reliable test in the diagnosis of growth hormone deficiency (GHD), but it is contraindicated in some patients. Recently, the use of GH-Releasing Peptide-2 (GHRP-2) has been validated and reported as a safe and reliable test for the diagnosis of adult severe GHD. We evaluated the GH response to GHRP-2 in 56 children with growth disorders to assess its efficacy. A dose of 2 μg/kg of GHRP-2 was administered intravenously and serum GH concentrations were determined. The Spearman correlation coefficient for GH peak values indicated a favorable correlation with the ITT (P<0.0001). Peak GH concentrations were significantly (p<0.0001) lower in children with (median:3.39 μg/l (ng/ml)) than without (25.10 μg/l (ng/ml)) GHD. In the analysis of sensitivity-specificity curves, the serum concentration at the point where sensitivity crosses specificity was 15 μg/l (ng/ml). The GHRP-2 test was safe and required only one hour or less, and was capable of diagnosing GHD in children. © Freund Publishing House Ltd. 2010 |
| abstract_unstemmed |
The insulin tolerance test (ITT) has been considered the most reliable test in the diagnosis of growth hormone deficiency (GHD), but it is contraindicated in some patients. Recently, the use of GH-Releasing Peptide-2 (GHRP-2) has been validated and reported as a safe and reliable test for the diagnosis of adult severe GHD. We evaluated the GH response to GHRP-2 in 56 children with growth disorders to assess its efficacy. A dose of 2 μg/kg of GHRP-2 was administered intravenously and serum GH concentrations were determined. The Spearman correlation coefficient for GH peak values indicated a favorable correlation with the ITT (P<0.0001). Peak GH concentrations were significantly (p<0.0001) lower in children with (median:3.39 μg/l (ng/ml)) than without (25.10 μg/l (ng/ml)) GHD. In the analysis of sensitivity-specificity curves, the serum concentration at the point where sensitivity crosses specificity was 15 μg/l (ng/ml). The GHRP-2 test was safe and required only one hour or less, and was capable of diagnosing GHD in children. © Freund Publishing House Ltd. 2010 |
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Growth Hormone Response to GH-Releasing Peptide-2 in Children |
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Asakura, Yumi Toyota, Yuko Muroya, Koji Adachi, Masanori |
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