Growth Hormone Response to GH-Releasing Peptide-2 in Children
The insulin tolerance test (ITT) has been considered the most reliable test in the diagnosis of growth hormone deficiency (GHD), but it is contraindicated in some patients. Recently, the use of GH-Releasing Peptide-2 (GHRP-2) has been validated and reported as a safe and reliable test for the diagno...
Ausführliche Beschreibung
Autor*in: |
---|
Format: |
E-Artikel |
---|
Erschienen: |
Walter de Gruyter GmbH & Co. KG ; 2010 |
---|
Schlagwörter: |
---|
Anmerkung: |
© Freund Publishing House Ltd. 2010 |
---|---|
Umfang: |
8 |
Reproduktion: |
Walter de Gruyter Online Zeitschriften |
---|---|
Übergeordnetes Werk: |
Enthalten in: The journal of pediatric endocrinology and metabolism - Berlin [u.a.] : de Gruyter, 1985, 23(2010), 5 vom: 17. Sept., Seite 473-480 |
Übergeordnetes Werk: |
volume:23 ; year:2010 ; number:5 ; day:17 ; month:09 ; pages:473-480 ; extent:8 |
Links: |
---|
DOI / URN: |
10.1515/jpem.2010.078 |
---|
Katalog-ID: |
NLEJ247127574 |
---|
LEADER | 01000caa a22002652 4500 | ||
---|---|---|---|
001 | NLEJ247127574 | ||
003 | DE-627 | ||
005 | 20220820030514.0 | ||
007 | cr uuu---uuuuu | ||
008 | 220814s2010 xx |||||o 00| ||und c | ||
024 | 7 | |a 10.1515/jpem.2010.078 |2 doi | |
028 | 5 | 2 | |a artikel_Grundlieferung.pp |
035 | |a (DE-627)NLEJ247127574 | ||
040 | |a DE-627 |b ger |c DE-627 |e rakwb | ||
245 | 1 | 0 | |a Growth Hormone Response to GH-Releasing Peptide-2 in Children |
264 | 1 | |b Walter de Gruyter GmbH & Co. KG |c 2010 | |
300 | |a 8 | ||
336 | |a Text |b txt |2 rdacontent | ||
337 | |a Computermedien |b c |2 rdamedia | ||
338 | |a Online-Ressource |b cr |2 rdacarrier | ||
500 | |a © Freund Publishing House Ltd. 2010 | ||
520 | |a The insulin tolerance test (ITT) has been considered the most reliable test in the diagnosis of growth hormone deficiency (GHD), but it is contraindicated in some patients. Recently, the use of GH-Releasing Peptide-2 (GHRP-2) has been validated and reported as a safe and reliable test for the diagnosis of adult severe GHD. We evaluated the GH response to GHRP-2 in 56 children with growth disorders to assess its efficacy. A dose of 2 μg/kg of GHRP-2 was administered intravenously and serum GH concentrations were determined. The Spearman correlation coefficient for GH peak values indicated a favorable correlation with the ITT (P<0.0001). Peak GH concentrations were significantly (p<0.0001) lower in children with (median:3.39 μg/l (ng/ml)) than without (25.10 μg/l (ng/ml)) GHD. In the analysis of sensitivity-specificity curves, the serum concentration at the point where sensitivity crosses specificity was 15 μg/l (ng/ml). The GHRP-2 test was safe and required only one hour or less, and was capable of diagnosing GHD in children. | ||
533 | |f Walter de Gruyter Online Zeitschriften | ||
650 | 4 | |a GH secretagogue | |
650 | 4 | |a GH-releasing peptide-2 | |
650 | 4 | |a growth hormone deficiency | |
650 | 4 | |a children | |
700 | 1 | |a Asakura, Yumi |4 oth | |
700 | 1 | |a Toyota, Yuko |4 oth | |
700 | 1 | |a Muroya, Koji |4 oth | |
700 | 1 | |a Adachi, Masanori |4 oth | |
773 | 0 | 8 | |i Enthalten in |t The journal of pediatric endocrinology and metabolism |d Berlin [u.a.] : de Gruyter, 1985 |g 23(2010), 5 vom: 17. Sept., Seite 473-480 |w (DE-627)NLEJ248236202 |w (DE-600)2583847-7 |x 2191-0251 |7 nnns |
773 | 1 | 8 | |g volume:23 |g year:2010 |g number:5 |g day:17 |g month:09 |g pages:473-480 |g extent:8 |
856 | 4 | 0 | |u https://doi.org/10.1515/jpem.2010.078 |z Deutschlandweit zugänglich |
912 | |a GBV_USEFLAG_U | ||
912 | |a ZDB-1-DGR | ||
912 | |a GBV_NL_ARTICLE | ||
951 | |a AR | ||
952 | |d 23 |j 2010 |e 5 |b 17 |c 09 |h 473-480 |g 8 |
matchkey_str |
article:21910251:2010----::rwhomnrsostgrlaiget |
---|---|
hierarchy_sort_str |
2010 |
publishDate |
2010 |
allfields |
10.1515/jpem.2010.078 doi artikel_Grundlieferung.pp (DE-627)NLEJ247127574 DE-627 ger DE-627 rakwb Growth Hormone Response to GH-Releasing Peptide-2 in Children Walter de Gruyter GmbH & Co. KG 2010 8 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Freund Publishing House Ltd. 2010 The insulin tolerance test (ITT) has been considered the most reliable test in the diagnosis of growth hormone deficiency (GHD), but it is contraindicated in some patients. Recently, the use of GH-Releasing Peptide-2 (GHRP-2) has been validated and reported as a safe and reliable test for the diagnosis of adult severe GHD. We evaluated the GH response to GHRP-2 in 56 children with growth disorders to assess its efficacy. A dose of 2 μg/kg of GHRP-2 was administered intravenously and serum GH concentrations were determined. The Spearman correlation coefficient for GH peak values indicated a favorable correlation with the ITT (P<0.0001). Peak GH concentrations were significantly (p<0.0001) lower in children with (median:3.39 μg/l (ng/ml)) than without (25.10 μg/l (ng/ml)) GHD. In the analysis of sensitivity-specificity curves, the serum concentration at the point where sensitivity crosses specificity was 15 μg/l (ng/ml). The GHRP-2 test was safe and required only one hour or less, and was capable of diagnosing GHD in children. Walter de Gruyter Online Zeitschriften GH secretagogue GH-releasing peptide-2 growth hormone deficiency children Asakura, Yumi oth Toyota, Yuko oth Muroya, Koji oth Adachi, Masanori oth Enthalten in The journal of pediatric endocrinology and metabolism Berlin [u.a.] : de Gruyter, 1985 23(2010), 5 vom: 17. Sept., Seite 473-480 (DE-627)NLEJ248236202 (DE-600)2583847-7 2191-0251 nnns volume:23 year:2010 number:5 day:17 month:09 pages:473-480 extent:8 https://doi.org/10.1515/jpem.2010.078 Deutschlandweit zugänglich GBV_USEFLAG_U ZDB-1-DGR GBV_NL_ARTICLE AR 23 2010 5 17 09 473-480 8 |
spelling |
10.1515/jpem.2010.078 doi artikel_Grundlieferung.pp (DE-627)NLEJ247127574 DE-627 ger DE-627 rakwb Growth Hormone Response to GH-Releasing Peptide-2 in Children Walter de Gruyter GmbH & Co. KG 2010 8 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Freund Publishing House Ltd. 2010 The insulin tolerance test (ITT) has been considered the most reliable test in the diagnosis of growth hormone deficiency (GHD), but it is contraindicated in some patients. Recently, the use of GH-Releasing Peptide-2 (GHRP-2) has been validated and reported as a safe and reliable test for the diagnosis of adult severe GHD. We evaluated the GH response to GHRP-2 in 56 children with growth disorders to assess its efficacy. A dose of 2 μg/kg of GHRP-2 was administered intravenously and serum GH concentrations were determined. The Spearman correlation coefficient for GH peak values indicated a favorable correlation with the ITT (P<0.0001). Peak GH concentrations were significantly (p<0.0001) lower in children with (median:3.39 μg/l (ng/ml)) than without (25.10 μg/l (ng/ml)) GHD. In the analysis of sensitivity-specificity curves, the serum concentration at the point where sensitivity crosses specificity was 15 μg/l (ng/ml). The GHRP-2 test was safe and required only one hour or less, and was capable of diagnosing GHD in children. Walter de Gruyter Online Zeitschriften GH secretagogue GH-releasing peptide-2 growth hormone deficiency children Asakura, Yumi oth Toyota, Yuko oth Muroya, Koji oth Adachi, Masanori oth Enthalten in The journal of pediatric endocrinology and metabolism Berlin [u.a.] : de Gruyter, 1985 23(2010), 5 vom: 17. Sept., Seite 473-480 (DE-627)NLEJ248236202 (DE-600)2583847-7 2191-0251 nnns volume:23 year:2010 number:5 day:17 month:09 pages:473-480 extent:8 https://doi.org/10.1515/jpem.2010.078 Deutschlandweit zugänglich GBV_USEFLAG_U ZDB-1-DGR GBV_NL_ARTICLE AR 23 2010 5 17 09 473-480 8 |
allfields_unstemmed |
10.1515/jpem.2010.078 doi artikel_Grundlieferung.pp (DE-627)NLEJ247127574 DE-627 ger DE-627 rakwb Growth Hormone Response to GH-Releasing Peptide-2 in Children Walter de Gruyter GmbH & Co. KG 2010 8 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Freund Publishing House Ltd. 2010 The insulin tolerance test (ITT) has been considered the most reliable test in the diagnosis of growth hormone deficiency (GHD), but it is contraindicated in some patients. Recently, the use of GH-Releasing Peptide-2 (GHRP-2) has been validated and reported as a safe and reliable test for the diagnosis of adult severe GHD. We evaluated the GH response to GHRP-2 in 56 children with growth disorders to assess its efficacy. A dose of 2 μg/kg of GHRP-2 was administered intravenously and serum GH concentrations were determined. The Spearman correlation coefficient for GH peak values indicated a favorable correlation with the ITT (P<0.0001). Peak GH concentrations were significantly (p<0.0001) lower in children with (median:3.39 μg/l (ng/ml)) than without (25.10 μg/l (ng/ml)) GHD. In the analysis of sensitivity-specificity curves, the serum concentration at the point where sensitivity crosses specificity was 15 μg/l (ng/ml). The GHRP-2 test was safe and required only one hour or less, and was capable of diagnosing GHD in children. Walter de Gruyter Online Zeitschriften GH secretagogue GH-releasing peptide-2 growth hormone deficiency children Asakura, Yumi oth Toyota, Yuko oth Muroya, Koji oth Adachi, Masanori oth Enthalten in The journal of pediatric endocrinology and metabolism Berlin [u.a.] : de Gruyter, 1985 23(2010), 5 vom: 17. Sept., Seite 473-480 (DE-627)NLEJ248236202 (DE-600)2583847-7 2191-0251 nnns volume:23 year:2010 number:5 day:17 month:09 pages:473-480 extent:8 https://doi.org/10.1515/jpem.2010.078 Deutschlandweit zugänglich GBV_USEFLAG_U ZDB-1-DGR GBV_NL_ARTICLE AR 23 2010 5 17 09 473-480 8 |
allfieldsGer |
10.1515/jpem.2010.078 doi artikel_Grundlieferung.pp (DE-627)NLEJ247127574 DE-627 ger DE-627 rakwb Growth Hormone Response to GH-Releasing Peptide-2 in Children Walter de Gruyter GmbH & Co. KG 2010 8 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Freund Publishing House Ltd. 2010 The insulin tolerance test (ITT) has been considered the most reliable test in the diagnosis of growth hormone deficiency (GHD), but it is contraindicated in some patients. Recently, the use of GH-Releasing Peptide-2 (GHRP-2) has been validated and reported as a safe and reliable test for the diagnosis of adult severe GHD. We evaluated the GH response to GHRP-2 in 56 children with growth disorders to assess its efficacy. A dose of 2 μg/kg of GHRP-2 was administered intravenously and serum GH concentrations were determined. The Spearman correlation coefficient for GH peak values indicated a favorable correlation with the ITT (P<0.0001). Peak GH concentrations were significantly (p<0.0001) lower in children with (median:3.39 μg/l (ng/ml)) than without (25.10 μg/l (ng/ml)) GHD. In the analysis of sensitivity-specificity curves, the serum concentration at the point where sensitivity crosses specificity was 15 μg/l (ng/ml). The GHRP-2 test was safe and required only one hour or less, and was capable of diagnosing GHD in children. Walter de Gruyter Online Zeitschriften GH secretagogue GH-releasing peptide-2 growth hormone deficiency children Asakura, Yumi oth Toyota, Yuko oth Muroya, Koji oth Adachi, Masanori oth Enthalten in The journal of pediatric endocrinology and metabolism Berlin [u.a.] : de Gruyter, 1985 23(2010), 5 vom: 17. Sept., Seite 473-480 (DE-627)NLEJ248236202 (DE-600)2583847-7 2191-0251 nnns volume:23 year:2010 number:5 day:17 month:09 pages:473-480 extent:8 https://doi.org/10.1515/jpem.2010.078 Deutschlandweit zugänglich GBV_USEFLAG_U ZDB-1-DGR GBV_NL_ARTICLE AR 23 2010 5 17 09 473-480 8 |
allfieldsSound |
10.1515/jpem.2010.078 doi artikel_Grundlieferung.pp (DE-627)NLEJ247127574 DE-627 ger DE-627 rakwb Growth Hormone Response to GH-Releasing Peptide-2 in Children Walter de Gruyter GmbH & Co. KG 2010 8 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Freund Publishing House Ltd. 2010 The insulin tolerance test (ITT) has been considered the most reliable test in the diagnosis of growth hormone deficiency (GHD), but it is contraindicated in some patients. Recently, the use of GH-Releasing Peptide-2 (GHRP-2) has been validated and reported as a safe and reliable test for the diagnosis of adult severe GHD. We evaluated the GH response to GHRP-2 in 56 children with growth disorders to assess its efficacy. A dose of 2 μg/kg of GHRP-2 was administered intravenously and serum GH concentrations were determined. The Spearman correlation coefficient for GH peak values indicated a favorable correlation with the ITT (P<0.0001). Peak GH concentrations were significantly (p<0.0001) lower in children with (median:3.39 μg/l (ng/ml)) than without (25.10 μg/l (ng/ml)) GHD. In the analysis of sensitivity-specificity curves, the serum concentration at the point where sensitivity crosses specificity was 15 μg/l (ng/ml). The GHRP-2 test was safe and required only one hour or less, and was capable of diagnosing GHD in children. Walter de Gruyter Online Zeitschriften GH secretagogue GH-releasing peptide-2 growth hormone deficiency children Asakura, Yumi oth Toyota, Yuko oth Muroya, Koji oth Adachi, Masanori oth Enthalten in The journal of pediatric endocrinology and metabolism Berlin [u.a.] : de Gruyter, 1985 23(2010), 5 vom: 17. Sept., Seite 473-480 (DE-627)NLEJ248236202 (DE-600)2583847-7 2191-0251 nnns volume:23 year:2010 number:5 day:17 month:09 pages:473-480 extent:8 https://doi.org/10.1515/jpem.2010.078 Deutschlandweit zugänglich GBV_USEFLAG_U ZDB-1-DGR GBV_NL_ARTICLE AR 23 2010 5 17 09 473-480 8 |
source |
Enthalten in The journal of pediatric endocrinology and metabolism 23(2010), 5 vom: 17. Sept., Seite 473-480 volume:23 year:2010 number:5 day:17 month:09 pages:473-480 extent:8 |
sourceStr |
Enthalten in The journal of pediatric endocrinology and metabolism 23(2010), 5 vom: 17. Sept., Seite 473-480 volume:23 year:2010 number:5 day:17 month:09 pages:473-480 extent:8 |
format_phy_str_mv |
Article |
institution |
findex.gbv.de |
topic_facet |
GH secretagogue GH-releasing peptide-2 growth hormone deficiency children |
isfreeaccess_bool |
false |
container_title |
The journal of pediatric endocrinology and metabolism |
authorswithroles_txt_mv |
Asakura, Yumi @@oth@@ Toyota, Yuko @@oth@@ Muroya, Koji @@oth@@ Adachi, Masanori @@oth@@ |
publishDateDaySort_date |
2010-09-17T00:00:00Z |
hierarchy_top_id |
NLEJ248236202 |
id |
NLEJ247127574 |
fullrecord |
<?xml version="1.0" encoding="UTF-8"?><collection xmlns="http://www.loc.gov/MARC21/slim"><record><leader>01000caa a22002652 4500</leader><controlfield tag="001">NLEJ247127574</controlfield><controlfield tag="003">DE-627</controlfield><controlfield tag="005">20220820030514.0</controlfield><controlfield tag="007">cr uuu---uuuuu</controlfield><controlfield tag="008">220814s2010 xx |||||o 00| ||und c</controlfield><datafield tag="024" ind1="7" ind2=" "><subfield code="a">10.1515/jpem.2010.078</subfield><subfield code="2">doi</subfield></datafield><datafield tag="028" ind1="5" ind2="2"><subfield code="a">artikel_Grundlieferung.pp</subfield></datafield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(DE-627)NLEJ247127574</subfield></datafield><datafield tag="040" ind1=" " ind2=" "><subfield code="a">DE-627</subfield><subfield code="b">ger</subfield><subfield code="c">DE-627</subfield><subfield code="e">rakwb</subfield></datafield><datafield tag="245" ind1="1" ind2="0"><subfield code="a">Growth Hormone Response to GH-Releasing Peptide-2 in Children</subfield></datafield><datafield tag="264" ind1=" " ind2="1"><subfield code="b">Walter de Gruyter GmbH & Co. KG</subfield><subfield code="c">2010</subfield></datafield><datafield tag="300" ind1=" " ind2=" "><subfield code="a">8</subfield></datafield><datafield tag="336" ind1=" " ind2=" "><subfield code="a">Text</subfield><subfield code="b">txt</subfield><subfield code="2">rdacontent</subfield></datafield><datafield tag="337" ind1=" " ind2=" "><subfield code="a">Computermedien</subfield><subfield code="b">c</subfield><subfield code="2">rdamedia</subfield></datafield><datafield tag="338" ind1=" " ind2=" "><subfield code="a">Online-Ressource</subfield><subfield code="b">cr</subfield><subfield code="2">rdacarrier</subfield></datafield><datafield tag="500" ind1=" " ind2=" "><subfield code="a">© Freund Publishing House Ltd. 2010</subfield></datafield><datafield tag="520" ind1=" " ind2=" "><subfield code="a">The insulin tolerance test (ITT) has been considered the most reliable test in the diagnosis of growth hormone deficiency (GHD), but it is contraindicated in some patients. Recently, the use of GH-Releasing Peptide-2 (GHRP-2) has been validated and reported as a safe and reliable test for the diagnosis of adult severe GHD. We evaluated the GH response to GHRP-2 in 56 children with growth disorders to assess its efficacy. A dose of 2 μg/kg of GHRP-2 was administered intravenously and serum GH concentrations were determined. The Spearman correlation coefficient for GH peak values indicated a favorable correlation with the ITT (P<0.0001). Peak GH concentrations were significantly (p<0.0001) lower in children with (median:3.39 μg/l (ng/ml)) than without (25.10 μg/l (ng/ml)) GHD. In the analysis of sensitivity-specificity curves, the serum concentration at the point where sensitivity crosses specificity was 15 μg/l (ng/ml). The GHRP-2 test was safe and required only one hour or less, and was capable of diagnosing GHD in children.</subfield></datafield><datafield tag="533" ind1=" " ind2=" "><subfield code="f">Walter de Gruyter Online Zeitschriften</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">GH secretagogue</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">GH-releasing peptide-2</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">growth hormone deficiency</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">children</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Asakura, Yumi</subfield><subfield code="4">oth</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Toyota, Yuko</subfield><subfield code="4">oth</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Muroya, Koji</subfield><subfield code="4">oth</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Adachi, Masanori</subfield><subfield code="4">oth</subfield></datafield><datafield tag="773" ind1="0" ind2="8"><subfield code="i">Enthalten in</subfield><subfield code="t">The journal of pediatric endocrinology and metabolism</subfield><subfield code="d">Berlin [u.a.] : de Gruyter, 1985</subfield><subfield code="g">23(2010), 5 vom: 17. Sept., Seite 473-480</subfield><subfield code="w">(DE-627)NLEJ248236202</subfield><subfield code="w">(DE-600)2583847-7</subfield><subfield code="x">2191-0251</subfield><subfield code="7">nnns</subfield></datafield><datafield tag="773" ind1="1" ind2="8"><subfield code="g">volume:23</subfield><subfield code="g">year:2010</subfield><subfield code="g">number:5</subfield><subfield code="g">day:17</subfield><subfield code="g">month:09</subfield><subfield code="g">pages:473-480</subfield><subfield code="g">extent:8</subfield></datafield><datafield tag="856" ind1="4" ind2="0"><subfield code="u">https://doi.org/10.1515/jpem.2010.078</subfield><subfield code="z">Deutschlandweit zugänglich</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_USEFLAG_U</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">ZDB-1-DGR</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_NL_ARTICLE</subfield></datafield><datafield tag="951" ind1=" " ind2=" "><subfield code="a">AR</subfield></datafield><datafield tag="952" ind1=" " ind2=" "><subfield code="d">23</subfield><subfield code="j">2010</subfield><subfield code="e">5</subfield><subfield code="b">17</subfield><subfield code="c">09</subfield><subfield code="h">473-480</subfield><subfield code="g">8</subfield></datafield></record></collection>
|
series2 |
Walter de Gruyter Online Zeitschriften |
ppnlink_with_tag_str_mv |
@@773@@(DE-627)NLEJ248236202 |
format |
electronic Article |
delete_txt_mv |
keep |
collection |
NL |
remote_str |
true |
illustrated |
Not Illustrated |
issn |
2191-0251 |
topic_title |
Growth Hormone Response to GH-Releasing Peptide-2 in Children GH secretagogue GH-releasing peptide-2 growth hormone deficiency children |
publisher |
Walter de Gruyter GmbH & Co. KG |
publisherStr |
Walter de Gruyter GmbH & Co. KG |
topic |
misc GH secretagogue misc GH-releasing peptide-2 misc growth hormone deficiency misc children |
spellingShingle |
misc GH secretagogue misc GH-releasing peptide-2 misc growth hormone deficiency misc children Growth Hormone Response to GH-Releasing Peptide-2 in Children |
topic_unstemmed |
misc GH secretagogue misc GH-releasing peptide-2 misc growth hormone deficiency misc children |
topic_browse |
misc GH secretagogue misc GH-releasing peptide-2 misc growth hormone deficiency misc children |
format_facet |
Elektronische Aufsätze Aufsätze Elektronische Ressource |
format_main_str_mv |
Text Zeitschrift/Artikel |
carriertype_str_mv |
cr |
author2_variant |
y a ya y t yt k m km m a ma |
hierarchy_parent_title |
The journal of pediatric endocrinology and metabolism |
hierarchy_parent_id |
NLEJ248236202 |
hierarchy_top_title |
The journal of pediatric endocrinology and metabolism |
isfreeaccess_txt |
false |
familylinks_str_mv |
(DE-627)NLEJ248236202 (DE-600)2583847-7 |
title |
Growth Hormone Response to GH-Releasing Peptide-2 in Children |
ctrlnum |
(DE-627)NLEJ247127574 |
title_full |
Growth Hormone Response to GH-Releasing Peptide-2 in Children |
journal |
The journal of pediatric endocrinology and metabolism |
journalStr |
The journal of pediatric endocrinology and metabolism |
isOA_bool |
false |
recordtype |
marc |
publishDateSort |
2010 |
contenttype_str_mv |
txt |
container_start_page |
473 |
container_volume |
23 |
physical |
8 |
format_se |
Elektronische Aufsätze |
doi_str_mv |
10.1515/jpem.2010.078 |
title_sort |
growth hormone response to gh-releasing peptide-2 in children |
title_auth |
Growth Hormone Response to GH-Releasing Peptide-2 in Children |
abstract |
The insulin tolerance test (ITT) has been considered the most reliable test in the diagnosis of growth hormone deficiency (GHD), but it is contraindicated in some patients. Recently, the use of GH-Releasing Peptide-2 (GHRP-2) has been validated and reported as a safe and reliable test for the diagnosis of adult severe GHD. We evaluated the GH response to GHRP-2 in 56 children with growth disorders to assess its efficacy. A dose of 2 μg/kg of GHRP-2 was administered intravenously and serum GH concentrations were determined. The Spearman correlation coefficient for GH peak values indicated a favorable correlation with the ITT (P<0.0001). Peak GH concentrations were significantly (p<0.0001) lower in children with (median:3.39 μg/l (ng/ml)) than without (25.10 μg/l (ng/ml)) GHD. In the analysis of sensitivity-specificity curves, the serum concentration at the point where sensitivity crosses specificity was 15 μg/l (ng/ml). The GHRP-2 test was safe and required only one hour or less, and was capable of diagnosing GHD in children. © Freund Publishing House Ltd. 2010 |
abstractGer |
The insulin tolerance test (ITT) has been considered the most reliable test in the diagnosis of growth hormone deficiency (GHD), but it is contraindicated in some patients. Recently, the use of GH-Releasing Peptide-2 (GHRP-2) has been validated and reported as a safe and reliable test for the diagnosis of adult severe GHD. We evaluated the GH response to GHRP-2 in 56 children with growth disorders to assess its efficacy. A dose of 2 μg/kg of GHRP-2 was administered intravenously and serum GH concentrations were determined. The Spearman correlation coefficient for GH peak values indicated a favorable correlation with the ITT (P<0.0001). Peak GH concentrations were significantly (p<0.0001) lower in children with (median:3.39 μg/l (ng/ml)) than without (25.10 μg/l (ng/ml)) GHD. In the analysis of sensitivity-specificity curves, the serum concentration at the point where sensitivity crosses specificity was 15 μg/l (ng/ml). The GHRP-2 test was safe and required only one hour or less, and was capable of diagnosing GHD in children. © Freund Publishing House Ltd. 2010 |
abstract_unstemmed |
The insulin tolerance test (ITT) has been considered the most reliable test in the diagnosis of growth hormone deficiency (GHD), but it is contraindicated in some patients. Recently, the use of GH-Releasing Peptide-2 (GHRP-2) has been validated and reported as a safe and reliable test for the diagnosis of adult severe GHD. We evaluated the GH response to GHRP-2 in 56 children with growth disorders to assess its efficacy. A dose of 2 μg/kg of GHRP-2 was administered intravenously and serum GH concentrations were determined. The Spearman correlation coefficient for GH peak values indicated a favorable correlation with the ITT (P<0.0001). Peak GH concentrations were significantly (p<0.0001) lower in children with (median:3.39 μg/l (ng/ml)) than without (25.10 μg/l (ng/ml)) GHD. In the analysis of sensitivity-specificity curves, the serum concentration at the point where sensitivity crosses specificity was 15 μg/l (ng/ml). The GHRP-2 test was safe and required only one hour or less, and was capable of diagnosing GHD in children. © Freund Publishing House Ltd. 2010 |
collection_details |
GBV_USEFLAG_U ZDB-1-DGR GBV_NL_ARTICLE |
container_issue |
5 |
title_short |
Growth Hormone Response to GH-Releasing Peptide-2 in Children |
url |
https://doi.org/10.1515/jpem.2010.078 |
remote_bool |
true |
author2 |
Asakura, Yumi Toyota, Yuko Muroya, Koji Adachi, Masanori |
author2Str |
Asakura, Yumi Toyota, Yuko Muroya, Koji Adachi, Masanori |
ppnlink |
NLEJ248236202 |
mediatype_str_mv |
c |
isOA_txt |
false |
hochschulschrift_bool |
false |
author2_role |
oth oth oth oth |
doi_str |
10.1515/jpem.2010.078 |
up_date |
2024-07-06T10:01:01.337Z |
_version_ |
1803823414078603264 |
fullrecord_marcxml |
<?xml version="1.0" encoding="UTF-8"?><collection xmlns="http://www.loc.gov/MARC21/slim"><record><leader>01000caa a22002652 4500</leader><controlfield tag="001">NLEJ247127574</controlfield><controlfield tag="003">DE-627</controlfield><controlfield tag="005">20220820030514.0</controlfield><controlfield tag="007">cr uuu---uuuuu</controlfield><controlfield tag="008">220814s2010 xx |||||o 00| ||und c</controlfield><datafield tag="024" ind1="7" ind2=" "><subfield code="a">10.1515/jpem.2010.078</subfield><subfield code="2">doi</subfield></datafield><datafield tag="028" ind1="5" ind2="2"><subfield code="a">artikel_Grundlieferung.pp</subfield></datafield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(DE-627)NLEJ247127574</subfield></datafield><datafield tag="040" ind1=" " ind2=" "><subfield code="a">DE-627</subfield><subfield code="b">ger</subfield><subfield code="c">DE-627</subfield><subfield code="e">rakwb</subfield></datafield><datafield tag="245" ind1="1" ind2="0"><subfield code="a">Growth Hormone Response to GH-Releasing Peptide-2 in Children</subfield></datafield><datafield tag="264" ind1=" " ind2="1"><subfield code="b">Walter de Gruyter GmbH & Co. KG</subfield><subfield code="c">2010</subfield></datafield><datafield tag="300" ind1=" " ind2=" "><subfield code="a">8</subfield></datafield><datafield tag="336" ind1=" " ind2=" "><subfield code="a">Text</subfield><subfield code="b">txt</subfield><subfield code="2">rdacontent</subfield></datafield><datafield tag="337" ind1=" " ind2=" "><subfield code="a">Computermedien</subfield><subfield code="b">c</subfield><subfield code="2">rdamedia</subfield></datafield><datafield tag="338" ind1=" " ind2=" "><subfield code="a">Online-Ressource</subfield><subfield code="b">cr</subfield><subfield code="2">rdacarrier</subfield></datafield><datafield tag="500" ind1=" " ind2=" "><subfield code="a">© Freund Publishing House Ltd. 2010</subfield></datafield><datafield tag="520" ind1=" " ind2=" "><subfield code="a">The insulin tolerance test (ITT) has been considered the most reliable test in the diagnosis of growth hormone deficiency (GHD), but it is contraindicated in some patients. Recently, the use of GH-Releasing Peptide-2 (GHRP-2) has been validated and reported as a safe and reliable test for the diagnosis of adult severe GHD. We evaluated the GH response to GHRP-2 in 56 children with growth disorders to assess its efficacy. A dose of 2 μg/kg of GHRP-2 was administered intravenously and serum GH concentrations were determined. The Spearman correlation coefficient for GH peak values indicated a favorable correlation with the ITT (P<0.0001). Peak GH concentrations were significantly (p<0.0001) lower in children with (median:3.39 μg/l (ng/ml)) than without (25.10 μg/l (ng/ml)) GHD. In the analysis of sensitivity-specificity curves, the serum concentration at the point where sensitivity crosses specificity was 15 μg/l (ng/ml). The GHRP-2 test was safe and required only one hour or less, and was capable of diagnosing GHD in children.</subfield></datafield><datafield tag="533" ind1=" " ind2=" "><subfield code="f">Walter de Gruyter Online Zeitschriften</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">GH secretagogue</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">GH-releasing peptide-2</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">growth hormone deficiency</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">children</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Asakura, Yumi</subfield><subfield code="4">oth</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Toyota, Yuko</subfield><subfield code="4">oth</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Muroya, Koji</subfield><subfield code="4">oth</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Adachi, Masanori</subfield><subfield code="4">oth</subfield></datafield><datafield tag="773" ind1="0" ind2="8"><subfield code="i">Enthalten in</subfield><subfield code="t">The journal of pediatric endocrinology and metabolism</subfield><subfield code="d">Berlin [u.a.] : de Gruyter, 1985</subfield><subfield code="g">23(2010), 5 vom: 17. Sept., Seite 473-480</subfield><subfield code="w">(DE-627)NLEJ248236202</subfield><subfield code="w">(DE-600)2583847-7</subfield><subfield code="x">2191-0251</subfield><subfield code="7">nnns</subfield></datafield><datafield tag="773" ind1="1" ind2="8"><subfield code="g">volume:23</subfield><subfield code="g">year:2010</subfield><subfield code="g">number:5</subfield><subfield code="g">day:17</subfield><subfield code="g">month:09</subfield><subfield code="g">pages:473-480</subfield><subfield code="g">extent:8</subfield></datafield><datafield tag="856" ind1="4" ind2="0"><subfield code="u">https://doi.org/10.1515/jpem.2010.078</subfield><subfield code="z">Deutschlandweit zugänglich</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_USEFLAG_U</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">ZDB-1-DGR</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_NL_ARTICLE</subfield></datafield><datafield tag="951" ind1=" " ind2=" "><subfield code="a">AR</subfield></datafield><datafield tag="952" ind1=" " ind2=" "><subfield code="d">23</subfield><subfield code="j">2010</subfield><subfield code="e">5</subfield><subfield code="b">17</subfield><subfield code="c">09</subfield><subfield code="h">473-480</subfield><subfield code="g">8</subfield></datafield></record></collection>
|
score |
7.3986425 |