Umbilical cord oxidative stress in infants of diabetic mothers and its relation to maternal hyperglycemia
Aims: There is growing body of evidence that oxidative stress plays an important role in the pathogenesis of diabetes mellitus (DM) and in development of maternal and fetal complications of diabetic pregnancies. The aim of the present study was to investigate total antioxidant capacity (TAC), total...
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E-Artikel |
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| Erschienen: |
Walter de Gruyter ; 2011 |
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| Anmerkung: |
©2011 by Walter de Gruyter Berlin Boston |
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| Umfang: |
4 |
| Reproduktion: |
Walter de Gruyter Online Zeitschriften |
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| Übergeordnetes Werk: |
Enthalten in: The journal of pediatric endocrinology and metabolism - Berlin [u.a.] : de Gruyter, 1985, 24(2011), 9-10 vom: 13. Aug., Seite 671-674 |
| Übergeordnetes Werk: |
volume:24 ; year:2011 ; number:9-10 ; day:13 ; month:08 ; pages:671-674 ; extent:4 |
| Links: |
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| DOI / URN: |
10.1515/JPEM.2011.315 |
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| Katalog-ID: |
NLEJ247131229 |
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| 520 | |a Aims: There is growing body of evidence that oxidative stress plays an important role in the pathogenesis of diabetes mellitus (DM) and in development of maternal and fetal complications of diabetic pregnancies. The aim of the present study was to investigate total antioxidant capacity (TAC), total oxidant status (TOS), and oxidative stress index (OSI) in infants of diabetic mothers (IDM) and to reveal the influence of maternal hyperglycemia on these parameters. Methods: A prospective controlled study was conducted between March 2010 and November 2010. Umbilical cord blood was taken from IDM and controls for TAC and TOS measurement, and OSI was calculated. IDM were divided into two groups, either of mothers treated with insulin during pregnancy or of those treated with a carbohydrate-restricted diet. Results: Thirty-six IDM and 14 infants born to non-diabetic mothers were enrolled. Infants of insulin-treated mothers (group 1) and infants of mothers managed with a carbohydrate-restricted diet (group 2) had significantly higher TOS (p<0.001 and p=0.001, respectively) and OSI (p<0.001 and p=0.001, respectively) levels compared to controls. However, TAC levels were similar in all three groups. Maternal HbA1cvalues were correlated to TOS (p<0.001, r=0.694) and OSI (p<0.001, r=0.683). Conclusions: Oxidative stress is increased in IDM, and a significant relation exists between the degree of maternal hyperglycemia in pregnancy and oxidative stress in the newborn at birth. | ||
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10.1515/JPEM.2011.315 doi artikel_Grundlieferung.pp (DE-627)NLEJ247131229 DE-627 ger DE-627 rakwb Umbilical cord oxidative stress in infants of diabetic mothers and its relation to maternal hyperglycemia Walter de Gruyter 2011 4 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier ©2011 by Walter de Gruyter Berlin Boston Aims: There is growing body of evidence that oxidative stress plays an important role in the pathogenesis of diabetes mellitus (DM) and in development of maternal and fetal complications of diabetic pregnancies. The aim of the present study was to investigate total antioxidant capacity (TAC), total oxidant status (TOS), and oxidative stress index (OSI) in infants of diabetic mothers (IDM) and to reveal the influence of maternal hyperglycemia on these parameters. Methods: A prospective controlled study was conducted between March 2010 and November 2010. Umbilical cord blood was taken from IDM and controls for TAC and TOS measurement, and OSI was calculated. IDM were divided into two groups, either of mothers treated with insulin during pregnancy or of those treated with a carbohydrate-restricted diet. Results: Thirty-six IDM and 14 infants born to non-diabetic mothers were enrolled. Infants of insulin-treated mothers (group 1) and infants of mothers managed with a carbohydrate-restricted diet (group 2) had significantly higher TOS (p<0.001 and p=0.001, respectively) and OSI (p<0.001 and p=0.001, respectively) levels compared to controls. However, TAC levels were similar in all three groups. Maternal HbA1cvalues were correlated to TOS (p<0.001, r=0.694) and OSI (p<0.001, r=0.683). Conclusions: Oxidative stress is increased in IDM, and a significant relation exists between the degree of maternal hyperglycemia in pregnancy and oxidative stress in the newborn at birth. Walter de Gruyter Online Zeitschriften infant of diabetic mother maternal hyperglycemia oxidative stress Sarikabadayi, Yusuf Unal oth Aydemir, Ozge oth Aydemir, Cumhur oth Uras, Nurdan oth Oguz, Serife Suna oth Erdeve, Omer oth Dilmen, Ugur oth Enthalten in The journal of pediatric endocrinology and metabolism Berlin [u.a.] : de Gruyter, 1985 24(2011), 9-10 vom: 13. Aug., Seite 671-674 (DE-627)NLEJ248236202 (DE-600)2583847-7 2191-0251 nnns volume:24 year:2011 number:9-10 day:13 month:08 pages:671-674 extent:4 https://doi.org/10.1515/JPEM.2011.315 Deutschlandweit zugänglich GBV_USEFLAG_U ZDB-1-DGR GBV_NL_ARTICLE AR 24 2011 9-10 13 08 671-674 4 |
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10.1515/JPEM.2011.315 doi artikel_Grundlieferung.pp (DE-627)NLEJ247131229 DE-627 ger DE-627 rakwb Umbilical cord oxidative stress in infants of diabetic mothers and its relation to maternal hyperglycemia Walter de Gruyter 2011 4 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier ©2011 by Walter de Gruyter Berlin Boston Aims: There is growing body of evidence that oxidative stress plays an important role in the pathogenesis of diabetes mellitus (DM) and in development of maternal and fetal complications of diabetic pregnancies. The aim of the present study was to investigate total antioxidant capacity (TAC), total oxidant status (TOS), and oxidative stress index (OSI) in infants of diabetic mothers (IDM) and to reveal the influence of maternal hyperglycemia on these parameters. Methods: A prospective controlled study was conducted between March 2010 and November 2010. Umbilical cord blood was taken from IDM and controls for TAC and TOS measurement, and OSI was calculated. IDM were divided into two groups, either of mothers treated with insulin during pregnancy or of those treated with a carbohydrate-restricted diet. Results: Thirty-six IDM and 14 infants born to non-diabetic mothers were enrolled. Infants of insulin-treated mothers (group 1) and infants of mothers managed with a carbohydrate-restricted diet (group 2) had significantly higher TOS (p<0.001 and p=0.001, respectively) and OSI (p<0.001 and p=0.001, respectively) levels compared to controls. However, TAC levels were similar in all three groups. Maternal HbA1cvalues were correlated to TOS (p<0.001, r=0.694) and OSI (p<0.001, r=0.683). Conclusions: Oxidative stress is increased in IDM, and a significant relation exists between the degree of maternal hyperglycemia in pregnancy and oxidative stress in the newborn at birth. Walter de Gruyter Online Zeitschriften infant of diabetic mother maternal hyperglycemia oxidative stress Sarikabadayi, Yusuf Unal oth Aydemir, Ozge oth Aydemir, Cumhur oth Uras, Nurdan oth Oguz, Serife Suna oth Erdeve, Omer oth Dilmen, Ugur oth Enthalten in The journal of pediatric endocrinology and metabolism Berlin [u.a.] : de Gruyter, 1985 24(2011), 9-10 vom: 13. Aug., Seite 671-674 (DE-627)NLEJ248236202 (DE-600)2583847-7 2191-0251 nnns volume:24 year:2011 number:9-10 day:13 month:08 pages:671-674 extent:4 https://doi.org/10.1515/JPEM.2011.315 Deutschlandweit zugänglich GBV_USEFLAG_U ZDB-1-DGR GBV_NL_ARTICLE AR 24 2011 9-10 13 08 671-674 4 |
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10.1515/JPEM.2011.315 doi artikel_Grundlieferung.pp (DE-627)NLEJ247131229 DE-627 ger DE-627 rakwb Umbilical cord oxidative stress in infants of diabetic mothers and its relation to maternal hyperglycemia Walter de Gruyter 2011 4 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier ©2011 by Walter de Gruyter Berlin Boston Aims: There is growing body of evidence that oxidative stress plays an important role in the pathogenesis of diabetes mellitus (DM) and in development of maternal and fetal complications of diabetic pregnancies. The aim of the present study was to investigate total antioxidant capacity (TAC), total oxidant status (TOS), and oxidative stress index (OSI) in infants of diabetic mothers (IDM) and to reveal the influence of maternal hyperglycemia on these parameters. Methods: A prospective controlled study was conducted between March 2010 and November 2010. Umbilical cord blood was taken from IDM and controls for TAC and TOS measurement, and OSI was calculated. IDM were divided into two groups, either of mothers treated with insulin during pregnancy or of those treated with a carbohydrate-restricted diet. Results: Thirty-six IDM and 14 infants born to non-diabetic mothers were enrolled. Infants of insulin-treated mothers (group 1) and infants of mothers managed with a carbohydrate-restricted diet (group 2) had significantly higher TOS (p<0.001 and p=0.001, respectively) and OSI (p<0.001 and p=0.001, respectively) levels compared to controls. However, TAC levels were similar in all three groups. Maternal HbA1cvalues were correlated to TOS (p<0.001, r=0.694) and OSI (p<0.001, r=0.683). Conclusions: Oxidative stress is increased in IDM, and a significant relation exists between the degree of maternal hyperglycemia in pregnancy and oxidative stress in the newborn at birth. Walter de Gruyter Online Zeitschriften infant of diabetic mother maternal hyperglycemia oxidative stress Sarikabadayi, Yusuf Unal oth Aydemir, Ozge oth Aydemir, Cumhur oth Uras, Nurdan oth Oguz, Serife Suna oth Erdeve, Omer oth Dilmen, Ugur oth Enthalten in The journal of pediatric endocrinology and metabolism Berlin [u.a.] : de Gruyter, 1985 24(2011), 9-10 vom: 13. Aug., Seite 671-674 (DE-627)NLEJ248236202 (DE-600)2583847-7 2191-0251 nnns volume:24 year:2011 number:9-10 day:13 month:08 pages:671-674 extent:4 https://doi.org/10.1515/JPEM.2011.315 Deutschlandweit zugänglich GBV_USEFLAG_U ZDB-1-DGR GBV_NL_ARTICLE AR 24 2011 9-10 13 08 671-674 4 |
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10.1515/JPEM.2011.315 doi artikel_Grundlieferung.pp (DE-627)NLEJ247131229 DE-627 ger DE-627 rakwb Umbilical cord oxidative stress in infants of diabetic mothers and its relation to maternal hyperglycemia Walter de Gruyter 2011 4 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier ©2011 by Walter de Gruyter Berlin Boston Aims: There is growing body of evidence that oxidative stress plays an important role in the pathogenesis of diabetes mellitus (DM) and in development of maternal and fetal complications of diabetic pregnancies. The aim of the present study was to investigate total antioxidant capacity (TAC), total oxidant status (TOS), and oxidative stress index (OSI) in infants of diabetic mothers (IDM) and to reveal the influence of maternal hyperglycemia on these parameters. Methods: A prospective controlled study was conducted between March 2010 and November 2010. Umbilical cord blood was taken from IDM and controls for TAC and TOS measurement, and OSI was calculated. IDM were divided into two groups, either of mothers treated with insulin during pregnancy or of those treated with a carbohydrate-restricted diet. Results: Thirty-six IDM and 14 infants born to non-diabetic mothers were enrolled. Infants of insulin-treated mothers (group 1) and infants of mothers managed with a carbohydrate-restricted diet (group 2) had significantly higher TOS (p<0.001 and p=0.001, respectively) and OSI (p<0.001 and p=0.001, respectively) levels compared to controls. However, TAC levels were similar in all three groups. Maternal HbA1cvalues were correlated to TOS (p<0.001, r=0.694) and OSI (p<0.001, r=0.683). Conclusions: Oxidative stress is increased in IDM, and a significant relation exists between the degree of maternal hyperglycemia in pregnancy and oxidative stress in the newborn at birth. Walter de Gruyter Online Zeitschriften infant of diabetic mother maternal hyperglycemia oxidative stress Sarikabadayi, Yusuf Unal oth Aydemir, Ozge oth Aydemir, Cumhur oth Uras, Nurdan oth Oguz, Serife Suna oth Erdeve, Omer oth Dilmen, Ugur oth Enthalten in The journal of pediatric endocrinology and metabolism Berlin [u.a.] : de Gruyter, 1985 24(2011), 9-10 vom: 13. Aug., Seite 671-674 (DE-627)NLEJ248236202 (DE-600)2583847-7 2191-0251 nnns volume:24 year:2011 number:9-10 day:13 month:08 pages:671-674 extent:4 https://doi.org/10.1515/JPEM.2011.315 Deutschlandweit zugänglich GBV_USEFLAG_U ZDB-1-DGR GBV_NL_ARTICLE AR 24 2011 9-10 13 08 671-674 4 |
| allfieldsSound |
10.1515/JPEM.2011.315 doi artikel_Grundlieferung.pp (DE-627)NLEJ247131229 DE-627 ger DE-627 rakwb Umbilical cord oxidative stress in infants of diabetic mothers and its relation to maternal hyperglycemia Walter de Gruyter 2011 4 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier ©2011 by Walter de Gruyter Berlin Boston Aims: There is growing body of evidence that oxidative stress plays an important role in the pathogenesis of diabetes mellitus (DM) and in development of maternal and fetal complications of diabetic pregnancies. The aim of the present study was to investigate total antioxidant capacity (TAC), total oxidant status (TOS), and oxidative stress index (OSI) in infants of diabetic mothers (IDM) and to reveal the influence of maternal hyperglycemia on these parameters. Methods: A prospective controlled study was conducted between March 2010 and November 2010. Umbilical cord blood was taken from IDM and controls for TAC and TOS measurement, and OSI was calculated. IDM were divided into two groups, either of mothers treated with insulin during pregnancy or of those treated with a carbohydrate-restricted diet. Results: Thirty-six IDM and 14 infants born to non-diabetic mothers were enrolled. Infants of insulin-treated mothers (group 1) and infants of mothers managed with a carbohydrate-restricted diet (group 2) had significantly higher TOS (p<0.001 and p=0.001, respectively) and OSI (p<0.001 and p=0.001, respectively) levels compared to controls. However, TAC levels were similar in all three groups. Maternal HbA1cvalues were correlated to TOS (p<0.001, r=0.694) and OSI (p<0.001, r=0.683). Conclusions: Oxidative stress is increased in IDM, and a significant relation exists between the degree of maternal hyperglycemia in pregnancy and oxidative stress in the newborn at birth. Walter de Gruyter Online Zeitschriften infant of diabetic mother maternal hyperglycemia oxidative stress Sarikabadayi, Yusuf Unal oth Aydemir, Ozge oth Aydemir, Cumhur oth Uras, Nurdan oth Oguz, Serife Suna oth Erdeve, Omer oth Dilmen, Ugur oth Enthalten in The journal of pediatric endocrinology and metabolism Berlin [u.a.] : de Gruyter, 1985 24(2011), 9-10 vom: 13. Aug., Seite 671-674 (DE-627)NLEJ248236202 (DE-600)2583847-7 2191-0251 nnns volume:24 year:2011 number:9-10 day:13 month:08 pages:671-674 extent:4 https://doi.org/10.1515/JPEM.2011.315 Deutschlandweit zugänglich GBV_USEFLAG_U ZDB-1-DGR GBV_NL_ARTICLE AR 24 2011 9-10 13 08 671-674 4 |
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Umbilical cord oxidative stress in infants of diabetic mothers and its relation to maternal hyperglycemia |
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The journal of pediatric endocrinology and metabolism |
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The journal of pediatric endocrinology and metabolism |
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2011 |
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10.1515/JPEM.2011.315 |
| title_sort |
umbilical cord oxidative stress in infants of diabetic mothers and its relation to maternal hyperglycemia |
| title_auth |
Umbilical cord oxidative stress in infants of diabetic mothers and its relation to maternal hyperglycemia |
| abstract |
Aims: There is growing body of evidence that oxidative stress plays an important role in the pathogenesis of diabetes mellitus (DM) and in development of maternal and fetal complications of diabetic pregnancies. The aim of the present study was to investigate total antioxidant capacity (TAC), total oxidant status (TOS), and oxidative stress index (OSI) in infants of diabetic mothers (IDM) and to reveal the influence of maternal hyperglycemia on these parameters. Methods: A prospective controlled study was conducted between March 2010 and November 2010. Umbilical cord blood was taken from IDM and controls for TAC and TOS measurement, and OSI was calculated. IDM were divided into two groups, either of mothers treated with insulin during pregnancy or of those treated with a carbohydrate-restricted diet. Results: Thirty-six IDM and 14 infants born to non-diabetic mothers were enrolled. Infants of insulin-treated mothers (group 1) and infants of mothers managed with a carbohydrate-restricted diet (group 2) had significantly higher TOS (p<0.001 and p=0.001, respectively) and OSI (p<0.001 and p=0.001, respectively) levels compared to controls. However, TAC levels were similar in all three groups. Maternal HbA1cvalues were correlated to TOS (p<0.001, r=0.694) and OSI (p<0.001, r=0.683). Conclusions: Oxidative stress is increased in IDM, and a significant relation exists between the degree of maternal hyperglycemia in pregnancy and oxidative stress in the newborn at birth. ©2011 by Walter de Gruyter Berlin Boston |
| abstractGer |
Aims: There is growing body of evidence that oxidative stress plays an important role in the pathogenesis of diabetes mellitus (DM) and in development of maternal and fetal complications of diabetic pregnancies. The aim of the present study was to investigate total antioxidant capacity (TAC), total oxidant status (TOS), and oxidative stress index (OSI) in infants of diabetic mothers (IDM) and to reveal the influence of maternal hyperglycemia on these parameters. Methods: A prospective controlled study was conducted between March 2010 and November 2010. Umbilical cord blood was taken from IDM and controls for TAC and TOS measurement, and OSI was calculated. IDM were divided into two groups, either of mothers treated with insulin during pregnancy or of those treated with a carbohydrate-restricted diet. Results: Thirty-six IDM and 14 infants born to non-diabetic mothers were enrolled. Infants of insulin-treated mothers (group 1) and infants of mothers managed with a carbohydrate-restricted diet (group 2) had significantly higher TOS (p<0.001 and p=0.001, respectively) and OSI (p<0.001 and p=0.001, respectively) levels compared to controls. However, TAC levels were similar in all three groups. Maternal HbA1cvalues were correlated to TOS (p<0.001, r=0.694) and OSI (p<0.001, r=0.683). Conclusions: Oxidative stress is increased in IDM, and a significant relation exists between the degree of maternal hyperglycemia in pregnancy and oxidative stress in the newborn at birth. ©2011 by Walter de Gruyter Berlin Boston |
| abstract_unstemmed |
Aims: There is growing body of evidence that oxidative stress plays an important role in the pathogenesis of diabetes mellitus (DM) and in development of maternal and fetal complications of diabetic pregnancies. The aim of the present study was to investigate total antioxidant capacity (TAC), total oxidant status (TOS), and oxidative stress index (OSI) in infants of diabetic mothers (IDM) and to reveal the influence of maternal hyperglycemia on these parameters. Methods: A prospective controlled study was conducted between March 2010 and November 2010. Umbilical cord blood was taken from IDM and controls for TAC and TOS measurement, and OSI was calculated. IDM were divided into two groups, either of mothers treated with insulin during pregnancy or of those treated with a carbohydrate-restricted diet. Results: Thirty-six IDM and 14 infants born to non-diabetic mothers were enrolled. Infants of insulin-treated mothers (group 1) and infants of mothers managed with a carbohydrate-restricted diet (group 2) had significantly higher TOS (p<0.001 and p=0.001, respectively) and OSI (p<0.001 and p=0.001, respectively) levels compared to controls. However, TAC levels were similar in all three groups. Maternal HbA1cvalues were correlated to TOS (p<0.001, r=0.694) and OSI (p<0.001, r=0.683). Conclusions: Oxidative stress is increased in IDM, and a significant relation exists between the degree of maternal hyperglycemia in pregnancy and oxidative stress in the newborn at birth. ©2011 by Walter de Gruyter Berlin Boston |
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Umbilical cord oxidative stress in infants of diabetic mothers and its relation to maternal hyperglycemia |
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https://doi.org/10.1515/JPEM.2011.315 |
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Sarikabadayi, Yusuf Unal Aydemir, Ozge Aydemir, Cumhur Uras, Nurdan Oguz, Serife Suna Erdeve, Omer Dilmen, Ugur |
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Sarikabadayi, Yusuf Unal Aydemir, Ozge Aydemir, Cumhur Uras, Nurdan Oguz, Serife Suna Erdeve, Omer Dilmen, Ugur |
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