Double exposure to intra-amniotic lipopolysaccharide and maternal betamethasone induces sustained increase of neutrophils in the lungs and disrupts alveolarization in newborn rats
Aim: We investigated the combined effects of intra-amniotic lipopolysaccharide (LPS) and maternal betamethasone (BMZ) on alveolarization using a newborn rat model. Methods: LPS (1.0 μg/sac) or vehicle was injected into the amniotic sacs of pregnant rats and BMZ (170 μg/kg) or vehicle was injected in...
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E-Artikel |
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De Gruyter ; 2013 |
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8 |
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Walter de Gruyter Online Zeitschriften |
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Enthalten in: Journal of perinatal medicine - Berlin [u.a.] : de Gruyter, 1973, 41(2013), 6 vom: 09. Aug., Seite 711-718 |
| Übergeordnetes Werk: |
volume:41 ; year:2013 ; number:6 ; day:09 ; month:08 ; pages:711-718 ; extent:8 |
| Links: |
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| DOI / URN: |
10.1515/jpm-2013-0063 |
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| Katalog-ID: |
NLEJ247134325 |
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| 245 | 1 | 0 | |a Double exposure to intra-amniotic lipopolysaccharide and maternal betamethasone induces sustained increase of neutrophils in the lungs and disrupts alveolarization in newborn rats |
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| 520 | |a Aim: We investigated the combined effects of intra-amniotic lipopolysaccharide (LPS) and maternal betamethasone (BMZ) on alveolarization using a newborn rat model. Methods: LPS (1.0 μg/sac) or vehicle was injected into the amniotic sacs of pregnant rats and BMZ (170 μg/kg) or vehicle was injected intramuscularly into the pregnant rats twice at 8-h intervals on gestation day 20. The rat pups were delivered spontaneously after 2–2.5 days and raised until the measurements were taken. Bronchoalveolar lavage was performed on days 2 and 5, and morphometric analyses of the lungs were performed on days 5 and 14. Results: Intra-amniotic LPS significantly increased the neutrophils in the bronchoalveolar lavage fluid (BALF) on day 2, but double exposure to LPS and BMZ significantly alleviated the neutrophil increase in the BALF. On day 5, while the neutrophils in the BALF decreased in the animals exposed to LPS alone, the neutrophil numbers in the BALF were steady in the animals exposed to both LPS and BMZ. Morphometric analyses on days 5 and 14 revealed a significant disruption of alveolarization only in the animals exposed to both LPS and BMZ. Conclusions: Our results suggested that double exposure to maternal BMZ and intra-amniotic LPS induces sustained increase of neutrophils in the lungs and disrupts alveolarization. | ||
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| 650 | 4 | |a Alveolarization | |
| 650 | 4 | |a bronchopulmonary dysplasia | |
| 650 | 4 | |a chorioamnionitis | |
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| 700 | 1 | |a Lee, Hyun Ju |4 oth | |
| 700 | 1 | |a Lee, Youn Jin |4 oth | |
| 700 | 1 | |a Jo, Heui Seung |4 oth | |
| 700 | 1 | |a Choi, Chang Won |4 oth | |
| 700 | 1 | |a Kim, Ee-Kyung |4 oth | |
| 700 | 1 | |a Kim, Han-Suk |4 oth | |
| 700 | 1 | |a Kim, Beyong Il |4 oth | |
| 700 | 1 | |a Choi, Jung-Hwan |4 oth | |
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10.1515/jpm-2013-0063 doi artikel_Grundlieferung.pp (DE-627)NLEJ247134325 DE-627 ger DE-627 rakwb Double exposure to intra-amniotic lipopolysaccharide and maternal betamethasone induces sustained increase of neutrophils in the lungs and disrupts alveolarization in newborn rats De Gruyter 2013 8 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Aim: We investigated the combined effects of intra-amniotic lipopolysaccharide (LPS) and maternal betamethasone (BMZ) on alveolarization using a newborn rat model. Methods: LPS (1.0 μg/sac) or vehicle was injected into the amniotic sacs of pregnant rats and BMZ (170 μg/kg) or vehicle was injected intramuscularly into the pregnant rats twice at 8-h intervals on gestation day 20. The rat pups were delivered spontaneously after 2–2.5 days and raised until the measurements were taken. Bronchoalveolar lavage was performed on days 2 and 5, and morphometric analyses of the lungs were performed on days 5 and 14. Results: Intra-amniotic LPS significantly increased the neutrophils in the bronchoalveolar lavage fluid (BALF) on day 2, but double exposure to LPS and BMZ significantly alleviated the neutrophil increase in the BALF. On day 5, while the neutrophils in the BALF decreased in the animals exposed to LPS alone, the neutrophil numbers in the BALF were steady in the animals exposed to both LPS and BMZ. Morphometric analyses on days 5 and 14 revealed a significant disruption of alveolarization only in the animals exposed to both LPS and BMZ. Conclusions: Our results suggested that double exposure to maternal BMZ and intra-amniotic LPS induces sustained increase of neutrophils in the lungs and disrupts alveolarization. Walter de Gruyter Online Zeitschriften Alveolarization bronchopulmonary dysplasia chorioamnionitis corticosteroid Lee, Hyun Ju oth Lee, Youn Jin oth Jo, Heui Seung oth Choi, Chang Won oth Kim, Ee-Kyung oth Kim, Han-Suk oth Kim, Beyong Il oth Choi, Jung-Hwan oth Enthalten in Journal of perinatal medicine Berlin [u.a.] : de Gruyter, 1973 41(2013), 6 vom: 09. Aug., Seite 711-718 (DE-627)NLEJ248236229 (DE-600)1467968-1 16193997 nnns volume:41 year:2013 number:6 day:09 month:08 pages:711-718 extent:8 https://doi.org/10.1515/jpm-2013-0063 Deutschlandweit zugänglich GBV_USEFLAG_U ZDB-1-DGR GBV_NL_ARTICLE AR 41 2013 6 09 08 711-718 8 |
| spelling |
10.1515/jpm-2013-0063 doi artikel_Grundlieferung.pp (DE-627)NLEJ247134325 DE-627 ger DE-627 rakwb Double exposure to intra-amniotic lipopolysaccharide and maternal betamethasone induces sustained increase of neutrophils in the lungs and disrupts alveolarization in newborn rats De Gruyter 2013 8 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Aim: We investigated the combined effects of intra-amniotic lipopolysaccharide (LPS) and maternal betamethasone (BMZ) on alveolarization using a newborn rat model. Methods: LPS (1.0 μg/sac) or vehicle was injected into the amniotic sacs of pregnant rats and BMZ (170 μg/kg) or vehicle was injected intramuscularly into the pregnant rats twice at 8-h intervals on gestation day 20. The rat pups were delivered spontaneously after 2–2.5 days and raised until the measurements were taken. Bronchoalveolar lavage was performed on days 2 and 5, and morphometric analyses of the lungs were performed on days 5 and 14. Results: Intra-amniotic LPS significantly increased the neutrophils in the bronchoalveolar lavage fluid (BALF) on day 2, but double exposure to LPS and BMZ significantly alleviated the neutrophil increase in the BALF. On day 5, while the neutrophils in the BALF decreased in the animals exposed to LPS alone, the neutrophil numbers in the BALF were steady in the animals exposed to both LPS and BMZ. Morphometric analyses on days 5 and 14 revealed a significant disruption of alveolarization only in the animals exposed to both LPS and BMZ. Conclusions: Our results suggested that double exposure to maternal BMZ and intra-amniotic LPS induces sustained increase of neutrophils in the lungs and disrupts alveolarization. Walter de Gruyter Online Zeitschriften Alveolarization bronchopulmonary dysplasia chorioamnionitis corticosteroid Lee, Hyun Ju oth Lee, Youn Jin oth Jo, Heui Seung oth Choi, Chang Won oth Kim, Ee-Kyung oth Kim, Han-Suk oth Kim, Beyong Il oth Choi, Jung-Hwan oth Enthalten in Journal of perinatal medicine Berlin [u.a.] : de Gruyter, 1973 41(2013), 6 vom: 09. Aug., Seite 711-718 (DE-627)NLEJ248236229 (DE-600)1467968-1 16193997 nnns volume:41 year:2013 number:6 day:09 month:08 pages:711-718 extent:8 https://doi.org/10.1515/jpm-2013-0063 Deutschlandweit zugänglich GBV_USEFLAG_U ZDB-1-DGR GBV_NL_ARTICLE AR 41 2013 6 09 08 711-718 8 |
| allfields_unstemmed |
10.1515/jpm-2013-0063 doi artikel_Grundlieferung.pp (DE-627)NLEJ247134325 DE-627 ger DE-627 rakwb Double exposure to intra-amniotic lipopolysaccharide and maternal betamethasone induces sustained increase of neutrophils in the lungs and disrupts alveolarization in newborn rats De Gruyter 2013 8 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Aim: We investigated the combined effects of intra-amniotic lipopolysaccharide (LPS) and maternal betamethasone (BMZ) on alveolarization using a newborn rat model. Methods: LPS (1.0 μg/sac) or vehicle was injected into the amniotic sacs of pregnant rats and BMZ (170 μg/kg) or vehicle was injected intramuscularly into the pregnant rats twice at 8-h intervals on gestation day 20. The rat pups were delivered spontaneously after 2–2.5 days and raised until the measurements were taken. Bronchoalveolar lavage was performed on days 2 and 5, and morphometric analyses of the lungs were performed on days 5 and 14. Results: Intra-amniotic LPS significantly increased the neutrophils in the bronchoalveolar lavage fluid (BALF) on day 2, but double exposure to LPS and BMZ significantly alleviated the neutrophil increase in the BALF. On day 5, while the neutrophils in the BALF decreased in the animals exposed to LPS alone, the neutrophil numbers in the BALF were steady in the animals exposed to both LPS and BMZ. Morphometric analyses on days 5 and 14 revealed a significant disruption of alveolarization only in the animals exposed to both LPS and BMZ. Conclusions: Our results suggested that double exposure to maternal BMZ and intra-amniotic LPS induces sustained increase of neutrophils in the lungs and disrupts alveolarization. Walter de Gruyter Online Zeitschriften Alveolarization bronchopulmonary dysplasia chorioamnionitis corticosteroid Lee, Hyun Ju oth Lee, Youn Jin oth Jo, Heui Seung oth Choi, Chang Won oth Kim, Ee-Kyung oth Kim, Han-Suk oth Kim, Beyong Il oth Choi, Jung-Hwan oth Enthalten in Journal of perinatal medicine Berlin [u.a.] : de Gruyter, 1973 41(2013), 6 vom: 09. Aug., Seite 711-718 (DE-627)NLEJ248236229 (DE-600)1467968-1 16193997 nnns volume:41 year:2013 number:6 day:09 month:08 pages:711-718 extent:8 https://doi.org/10.1515/jpm-2013-0063 Deutschlandweit zugänglich GBV_USEFLAG_U ZDB-1-DGR GBV_NL_ARTICLE AR 41 2013 6 09 08 711-718 8 |
| allfieldsGer |
10.1515/jpm-2013-0063 doi artikel_Grundlieferung.pp (DE-627)NLEJ247134325 DE-627 ger DE-627 rakwb Double exposure to intra-amniotic lipopolysaccharide and maternal betamethasone induces sustained increase of neutrophils in the lungs and disrupts alveolarization in newborn rats De Gruyter 2013 8 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Aim: We investigated the combined effects of intra-amniotic lipopolysaccharide (LPS) and maternal betamethasone (BMZ) on alveolarization using a newborn rat model. Methods: LPS (1.0 μg/sac) or vehicle was injected into the amniotic sacs of pregnant rats and BMZ (170 μg/kg) or vehicle was injected intramuscularly into the pregnant rats twice at 8-h intervals on gestation day 20. The rat pups were delivered spontaneously after 2–2.5 days and raised until the measurements were taken. Bronchoalveolar lavage was performed on days 2 and 5, and morphometric analyses of the lungs were performed on days 5 and 14. Results: Intra-amniotic LPS significantly increased the neutrophils in the bronchoalveolar lavage fluid (BALF) on day 2, but double exposure to LPS and BMZ significantly alleviated the neutrophil increase in the BALF. On day 5, while the neutrophils in the BALF decreased in the animals exposed to LPS alone, the neutrophil numbers in the BALF were steady in the animals exposed to both LPS and BMZ. Morphometric analyses on days 5 and 14 revealed a significant disruption of alveolarization only in the animals exposed to both LPS and BMZ. Conclusions: Our results suggested that double exposure to maternal BMZ and intra-amniotic LPS induces sustained increase of neutrophils in the lungs and disrupts alveolarization. Walter de Gruyter Online Zeitschriften Alveolarization bronchopulmonary dysplasia chorioamnionitis corticosteroid Lee, Hyun Ju oth Lee, Youn Jin oth Jo, Heui Seung oth Choi, Chang Won oth Kim, Ee-Kyung oth Kim, Han-Suk oth Kim, Beyong Il oth Choi, Jung-Hwan oth Enthalten in Journal of perinatal medicine Berlin [u.a.] : de Gruyter, 1973 41(2013), 6 vom: 09. Aug., Seite 711-718 (DE-627)NLEJ248236229 (DE-600)1467968-1 16193997 nnns volume:41 year:2013 number:6 day:09 month:08 pages:711-718 extent:8 https://doi.org/10.1515/jpm-2013-0063 Deutschlandweit zugänglich GBV_USEFLAG_U ZDB-1-DGR GBV_NL_ARTICLE AR 41 2013 6 09 08 711-718 8 |
| allfieldsSound |
10.1515/jpm-2013-0063 doi artikel_Grundlieferung.pp (DE-627)NLEJ247134325 DE-627 ger DE-627 rakwb Double exposure to intra-amniotic lipopolysaccharide and maternal betamethasone induces sustained increase of neutrophils in the lungs and disrupts alveolarization in newborn rats De Gruyter 2013 8 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Aim: We investigated the combined effects of intra-amniotic lipopolysaccharide (LPS) and maternal betamethasone (BMZ) on alveolarization using a newborn rat model. Methods: LPS (1.0 μg/sac) or vehicle was injected into the amniotic sacs of pregnant rats and BMZ (170 μg/kg) or vehicle was injected intramuscularly into the pregnant rats twice at 8-h intervals on gestation day 20. The rat pups were delivered spontaneously after 2–2.5 days and raised until the measurements were taken. Bronchoalveolar lavage was performed on days 2 and 5, and morphometric analyses of the lungs were performed on days 5 and 14. Results: Intra-amniotic LPS significantly increased the neutrophils in the bronchoalveolar lavage fluid (BALF) on day 2, but double exposure to LPS and BMZ significantly alleviated the neutrophil increase in the BALF. On day 5, while the neutrophils in the BALF decreased in the animals exposed to LPS alone, the neutrophil numbers in the BALF were steady in the animals exposed to both LPS and BMZ. Morphometric analyses on days 5 and 14 revealed a significant disruption of alveolarization only in the animals exposed to both LPS and BMZ. Conclusions: Our results suggested that double exposure to maternal BMZ and intra-amniotic LPS induces sustained increase of neutrophils in the lungs and disrupts alveolarization. Walter de Gruyter Online Zeitschriften Alveolarization bronchopulmonary dysplasia chorioamnionitis corticosteroid Lee, Hyun Ju oth Lee, Youn Jin oth Jo, Heui Seung oth Choi, Chang Won oth Kim, Ee-Kyung oth Kim, Han-Suk oth Kim, Beyong Il oth Choi, Jung-Hwan oth Enthalten in Journal of perinatal medicine Berlin [u.a.] : de Gruyter, 1973 41(2013), 6 vom: 09. Aug., Seite 711-718 (DE-627)NLEJ248236229 (DE-600)1467968-1 16193997 nnns volume:41 year:2013 number:6 day:09 month:08 pages:711-718 extent:8 https://doi.org/10.1515/jpm-2013-0063 Deutschlandweit zugänglich GBV_USEFLAG_U ZDB-1-DGR GBV_NL_ARTICLE AR 41 2013 6 09 08 711-718 8 |
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double exposure to intra-amniotic lipopolysaccharide and maternal betamethasone induces sustained increase of neutrophils in the lungs and disrupts alveolarization in newborn rats |
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Double exposure to intra-amniotic lipopolysaccharide and maternal betamethasone induces sustained increase of neutrophils in the lungs and disrupts alveolarization in newborn rats |
| abstract |
Aim: We investigated the combined effects of intra-amniotic lipopolysaccharide (LPS) and maternal betamethasone (BMZ) on alveolarization using a newborn rat model. Methods: LPS (1.0 μg/sac) or vehicle was injected into the amniotic sacs of pregnant rats and BMZ (170 μg/kg) or vehicle was injected intramuscularly into the pregnant rats twice at 8-h intervals on gestation day 20. The rat pups were delivered spontaneously after 2–2.5 days and raised until the measurements were taken. Bronchoalveolar lavage was performed on days 2 and 5, and morphometric analyses of the lungs were performed on days 5 and 14. Results: Intra-amniotic LPS significantly increased the neutrophils in the bronchoalveolar lavage fluid (BALF) on day 2, but double exposure to LPS and BMZ significantly alleviated the neutrophil increase in the BALF. On day 5, while the neutrophils in the BALF decreased in the animals exposed to LPS alone, the neutrophil numbers in the BALF were steady in the animals exposed to both LPS and BMZ. Morphometric analyses on days 5 and 14 revealed a significant disruption of alveolarization only in the animals exposed to both LPS and BMZ. Conclusions: Our results suggested that double exposure to maternal BMZ and intra-amniotic LPS induces sustained increase of neutrophils in the lungs and disrupts alveolarization. |
| abstractGer |
Aim: We investigated the combined effects of intra-amniotic lipopolysaccharide (LPS) and maternal betamethasone (BMZ) on alveolarization using a newborn rat model. Methods: LPS (1.0 μg/sac) or vehicle was injected into the amniotic sacs of pregnant rats and BMZ (170 μg/kg) or vehicle was injected intramuscularly into the pregnant rats twice at 8-h intervals on gestation day 20. The rat pups were delivered spontaneously after 2–2.5 days and raised until the measurements were taken. Bronchoalveolar lavage was performed on days 2 and 5, and morphometric analyses of the lungs were performed on days 5 and 14. Results: Intra-amniotic LPS significantly increased the neutrophils in the bronchoalveolar lavage fluid (BALF) on day 2, but double exposure to LPS and BMZ significantly alleviated the neutrophil increase in the BALF. On day 5, while the neutrophils in the BALF decreased in the animals exposed to LPS alone, the neutrophil numbers in the BALF were steady in the animals exposed to both LPS and BMZ. Morphometric analyses on days 5 and 14 revealed a significant disruption of alveolarization only in the animals exposed to both LPS and BMZ. Conclusions: Our results suggested that double exposure to maternal BMZ and intra-amniotic LPS induces sustained increase of neutrophils in the lungs and disrupts alveolarization. |
| abstract_unstemmed |
Aim: We investigated the combined effects of intra-amniotic lipopolysaccharide (LPS) and maternal betamethasone (BMZ) on alveolarization using a newborn rat model. Methods: LPS (1.0 μg/sac) or vehicle was injected into the amniotic sacs of pregnant rats and BMZ (170 μg/kg) or vehicle was injected intramuscularly into the pregnant rats twice at 8-h intervals on gestation day 20. The rat pups were delivered spontaneously after 2–2.5 days and raised until the measurements were taken. Bronchoalveolar lavage was performed on days 2 and 5, and morphometric analyses of the lungs were performed on days 5 and 14. Results: Intra-amniotic LPS significantly increased the neutrophils in the bronchoalveolar lavage fluid (BALF) on day 2, but double exposure to LPS and BMZ significantly alleviated the neutrophil increase in the BALF. On day 5, while the neutrophils in the BALF decreased in the animals exposed to LPS alone, the neutrophil numbers in the BALF were steady in the animals exposed to both LPS and BMZ. Morphometric analyses on days 5 and 14 revealed a significant disruption of alveolarization only in the animals exposed to both LPS and BMZ. Conclusions: Our results suggested that double exposure to maternal BMZ and intra-amniotic LPS induces sustained increase of neutrophils in the lungs and disrupts alveolarization. |
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| title_short |
Double exposure to intra-amniotic lipopolysaccharide and maternal betamethasone induces sustained increase of neutrophils in the lungs and disrupts alveolarization in newborn rats |
| url |
https://doi.org/10.1515/jpm-2013-0063 |
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| author2 |
Lee, Hyun Ju Lee, Youn Jin Jo, Heui Seung Choi, Chang Won Kim, Ee-Kyung Kim, Han-Suk Kim, Beyong Il Choi, Jung-Hwan |
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Lee, Hyun Ju Lee, Youn Jin Jo, Heui Seung Choi, Chang Won Kim, Ee-Kyung Kim, Han-Suk Kim, Beyong Il Choi, Jung-Hwan |
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| doi_str |
10.1515/jpm-2013-0063 |
| up_date |
2024-07-06T10:02:20.338Z |
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