Coagulation and fibrinolysis related cytokine imbalance in preeclampsia: the role of placental trophoblasts
Objective: Cytokine imbalance might have a pivotal role in hypercoagulability seen in preeclampsia. Our objective was to determine the relationship of blood coagulation related factors in placental tissue and peripheral blood in preeclamptic and normal pregnancies. Methods: We compared mRNA and prot...
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Walter de Gruyter ; 2009 2009 |
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©2009 by Walter de Gruyter Berlin New York |
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6 |
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Walter de Gruyter Online Zeitschriften |
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Enthalten in: Journal of perinatal medicine - Berlin [u.a.] : de Gruyter, 1973, 37(2009 2009), 4 vom: 17 17., Seite 343-348 |
| Übergeordnetes Werk: |
volume:37 ; year:2009 2009 ; number:4 ; day:17 17 ; month:03 ; pages:343-348 ; extent:6 |
| Links: |
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| DOI / URN: |
10.1515/JPM.2009.060 |
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| Katalog-ID: |
NLEJ247144320 |
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| 245 | 1 | 0 | |a Coagulation and fibrinolysis related cytokine imbalance in preeclampsia: the role of placental trophoblasts |
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| 520 | |a Objective: Cytokine imbalance might have a pivotal role in hypercoagulability seen in preeclampsia. Our objective was to determine the relationship of blood coagulation related factors in placental tissue and peripheral blood in preeclamptic and normal pregnancies. Methods: We compared mRNA and protein levels of tissue-type plasminogen activator (t-PA), plasminogen activator inhibitor-1 (PAI-1), and tissue factor (TF) in the placenta of normal and preeclamptic pregnancies. Placental and peripheral blood t-PA and PAI-1 levels were examined. Trophoblasts were used to study the effects of hypoxia, hypoxia-reperfusion, and inflammatory cytokines on t-PA, PAI-1, tissue factor pathway inhibitor (TFPI), and TF. Results: PAI-1 and TF mRNA and protein levels were higher in placental tissue of preeclamptic pregnancies and in the peripheral blood of patients with preeclampsia. mRNA and protein secretion of TF, TFPI, PAI-1, but not t-PA, was increased in trophoblast cell culture under hypoxia and hypoxia-reoxygenation. Cell cultures with high levels of tumor necrosis factor-alpha (TNF-α) exhibited increased expression and secretion of TF and PAI-1, decreased TFPI, and no significant change of t-PA. Conclusions: Imbalanced synthesis of t-PA, PAI-1, TFPI, and TF in trophoblasts may contribute to hypercoagulability in patients with preeclampsia. | ||
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| 700 | 1 | |a Lin, Jian-Hua |4 oth | |
| 700 | 1 | |a Ding, Chuan-Wei |4 oth | |
| 700 | 1 | |a Zuo, Ye |4 oth | |
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10.1515/JPM.2009.060 doi artikel_Grundlieferung.pp (DE-627)NLEJ247144320 DE-627 ger DE-627 rakwb Coagulation and fibrinolysis related cytokine imbalance in preeclampsia: the role of placental trophoblasts Walter de Gruyter 2009 2009 6 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier ©2009 by Walter de Gruyter Berlin New York Objective: Cytokine imbalance might have a pivotal role in hypercoagulability seen in preeclampsia. Our objective was to determine the relationship of blood coagulation related factors in placental tissue and peripheral blood in preeclamptic and normal pregnancies. Methods: We compared mRNA and protein levels of tissue-type plasminogen activator (t-PA), plasminogen activator inhibitor-1 (PAI-1), and tissue factor (TF) in the placenta of normal and preeclamptic pregnancies. Placental and peripheral blood t-PA and PAI-1 levels were examined. Trophoblasts were used to study the effects of hypoxia, hypoxia-reperfusion, and inflammatory cytokines on t-PA, PAI-1, tissue factor pathway inhibitor (TFPI), and TF. Results: PAI-1 and TF mRNA and protein levels were higher in placental tissue of preeclamptic pregnancies and in the peripheral blood of patients with preeclampsia. mRNA and protein secretion of TF, TFPI, PAI-1, but not t-PA, was increased in trophoblast cell culture under hypoxia and hypoxia-reoxygenation. Cell cultures with high levels of tumor necrosis factor-alpha (TNF-α) exhibited increased expression and secretion of TF and PAI-1, decreased TFPI, and no significant change of t-PA. Conclusions: Imbalanced synthesis of t-PA, PAI-1, TFPI, and TF in trophoblasts may contribute to hypercoagulability in patients with preeclampsia. Walter de Gruyter Online Zeitschriften Cytokines hypercoagulability preeclampsia Teng, Yin-Cheng oth Lin, Qi-De oth Lin, Jian-Hua oth Ding, Chuan-Wei oth Zuo, Ye oth Enthalten in Journal of perinatal medicine Berlin [u.a.] : de Gruyter, 1973 37(2009 2009), 4 vom: 17 17., Seite 343-348 (DE-627)NLEJ248236229 (DE-600)1467968-1 16193997 nnns volume:37 year:2009 2009 number:4 day:17 17 month:03 pages:343-348 extent:6 https://doi.org/10.1515/JPM.2009.060 Deutschlandweit zugänglich GBV_USEFLAG_U ZDB-1-DGR GBV_NL_ARTICLE AR 37 2009 2009 4 17 17 03 03 343-348 6 |
| spelling |
10.1515/JPM.2009.060 doi artikel_Grundlieferung.pp (DE-627)NLEJ247144320 DE-627 ger DE-627 rakwb Coagulation and fibrinolysis related cytokine imbalance in preeclampsia: the role of placental trophoblasts Walter de Gruyter 2009 2009 6 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier ©2009 by Walter de Gruyter Berlin New York Objective: Cytokine imbalance might have a pivotal role in hypercoagulability seen in preeclampsia. Our objective was to determine the relationship of blood coagulation related factors in placental tissue and peripheral blood in preeclamptic and normal pregnancies. Methods: We compared mRNA and protein levels of tissue-type plasminogen activator (t-PA), plasminogen activator inhibitor-1 (PAI-1), and tissue factor (TF) in the placenta of normal and preeclamptic pregnancies. Placental and peripheral blood t-PA and PAI-1 levels were examined. Trophoblasts were used to study the effects of hypoxia, hypoxia-reperfusion, and inflammatory cytokines on t-PA, PAI-1, tissue factor pathway inhibitor (TFPI), and TF. Results: PAI-1 and TF mRNA and protein levels were higher in placental tissue of preeclamptic pregnancies and in the peripheral blood of patients with preeclampsia. mRNA and protein secretion of TF, TFPI, PAI-1, but not t-PA, was increased in trophoblast cell culture under hypoxia and hypoxia-reoxygenation. Cell cultures with high levels of tumor necrosis factor-alpha (TNF-α) exhibited increased expression and secretion of TF and PAI-1, decreased TFPI, and no significant change of t-PA. Conclusions: Imbalanced synthesis of t-PA, PAI-1, TFPI, and TF in trophoblasts may contribute to hypercoagulability in patients with preeclampsia. Walter de Gruyter Online Zeitschriften Cytokines hypercoagulability preeclampsia Teng, Yin-Cheng oth Lin, Qi-De oth Lin, Jian-Hua oth Ding, Chuan-Wei oth Zuo, Ye oth Enthalten in Journal of perinatal medicine Berlin [u.a.] : de Gruyter, 1973 37(2009 2009), 4 vom: 17 17., Seite 343-348 (DE-627)NLEJ248236229 (DE-600)1467968-1 16193997 nnns volume:37 year:2009 2009 number:4 day:17 17 month:03 pages:343-348 extent:6 https://doi.org/10.1515/JPM.2009.060 Deutschlandweit zugänglich GBV_USEFLAG_U ZDB-1-DGR GBV_NL_ARTICLE AR 37 2009 2009 4 17 17 03 03 343-348 6 |
| allfields_unstemmed |
10.1515/JPM.2009.060 doi artikel_Grundlieferung.pp (DE-627)NLEJ247144320 DE-627 ger DE-627 rakwb Coagulation and fibrinolysis related cytokine imbalance in preeclampsia: the role of placental trophoblasts Walter de Gruyter 2009 2009 6 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier ©2009 by Walter de Gruyter Berlin New York Objective: Cytokine imbalance might have a pivotal role in hypercoagulability seen in preeclampsia. Our objective was to determine the relationship of blood coagulation related factors in placental tissue and peripheral blood in preeclamptic and normal pregnancies. Methods: We compared mRNA and protein levels of tissue-type plasminogen activator (t-PA), plasminogen activator inhibitor-1 (PAI-1), and tissue factor (TF) in the placenta of normal and preeclamptic pregnancies. Placental and peripheral blood t-PA and PAI-1 levels were examined. Trophoblasts were used to study the effects of hypoxia, hypoxia-reperfusion, and inflammatory cytokines on t-PA, PAI-1, tissue factor pathway inhibitor (TFPI), and TF. Results: PAI-1 and TF mRNA and protein levels were higher in placental tissue of preeclamptic pregnancies and in the peripheral blood of patients with preeclampsia. mRNA and protein secretion of TF, TFPI, PAI-1, but not t-PA, was increased in trophoblast cell culture under hypoxia and hypoxia-reoxygenation. Cell cultures with high levels of tumor necrosis factor-alpha (TNF-α) exhibited increased expression and secretion of TF and PAI-1, decreased TFPI, and no significant change of t-PA. Conclusions: Imbalanced synthesis of t-PA, PAI-1, TFPI, and TF in trophoblasts may contribute to hypercoagulability in patients with preeclampsia. Walter de Gruyter Online Zeitschriften Cytokines hypercoagulability preeclampsia Teng, Yin-Cheng oth Lin, Qi-De oth Lin, Jian-Hua oth Ding, Chuan-Wei oth Zuo, Ye oth Enthalten in Journal of perinatal medicine Berlin [u.a.] : de Gruyter, 1973 37(2009 2009), 4 vom: 17 17., Seite 343-348 (DE-627)NLEJ248236229 (DE-600)1467968-1 16193997 nnns volume:37 year:2009 2009 number:4 day:17 17 month:03 pages:343-348 extent:6 https://doi.org/10.1515/JPM.2009.060 Deutschlandweit zugänglich GBV_USEFLAG_U ZDB-1-DGR GBV_NL_ARTICLE AR 37 2009 2009 4 17 17 03 03 343-348 6 |
| allfieldsGer |
10.1515/JPM.2009.060 doi artikel_Grundlieferung.pp (DE-627)NLEJ247144320 DE-627 ger DE-627 rakwb Coagulation and fibrinolysis related cytokine imbalance in preeclampsia: the role of placental trophoblasts Walter de Gruyter 2009 2009 6 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier ©2009 by Walter de Gruyter Berlin New York Objective: Cytokine imbalance might have a pivotal role in hypercoagulability seen in preeclampsia. Our objective was to determine the relationship of blood coagulation related factors in placental tissue and peripheral blood in preeclamptic and normal pregnancies. Methods: We compared mRNA and protein levels of tissue-type plasminogen activator (t-PA), plasminogen activator inhibitor-1 (PAI-1), and tissue factor (TF) in the placenta of normal and preeclamptic pregnancies. Placental and peripheral blood t-PA and PAI-1 levels were examined. Trophoblasts were used to study the effects of hypoxia, hypoxia-reperfusion, and inflammatory cytokines on t-PA, PAI-1, tissue factor pathway inhibitor (TFPI), and TF. Results: PAI-1 and TF mRNA and protein levels were higher in placental tissue of preeclamptic pregnancies and in the peripheral blood of patients with preeclampsia. mRNA and protein secretion of TF, TFPI, PAI-1, but not t-PA, was increased in trophoblast cell culture under hypoxia and hypoxia-reoxygenation. Cell cultures with high levels of tumor necrosis factor-alpha (TNF-α) exhibited increased expression and secretion of TF and PAI-1, decreased TFPI, and no significant change of t-PA. Conclusions: Imbalanced synthesis of t-PA, PAI-1, TFPI, and TF in trophoblasts may contribute to hypercoagulability in patients with preeclampsia. Walter de Gruyter Online Zeitschriften Cytokines hypercoagulability preeclampsia Teng, Yin-Cheng oth Lin, Qi-De oth Lin, Jian-Hua oth Ding, Chuan-Wei oth Zuo, Ye oth Enthalten in Journal of perinatal medicine Berlin [u.a.] : de Gruyter, 1973 37(2009 2009), 4 vom: 17 17., Seite 343-348 (DE-627)NLEJ248236229 (DE-600)1467968-1 16193997 nnns volume:37 year:2009 2009 number:4 day:17 17 month:03 pages:343-348 extent:6 https://doi.org/10.1515/JPM.2009.060 Deutschlandweit zugänglich GBV_USEFLAG_U ZDB-1-DGR GBV_NL_ARTICLE AR 37 2009 2009 4 17 17 03 03 343-348 6 |
| allfieldsSound |
10.1515/JPM.2009.060 doi artikel_Grundlieferung.pp (DE-627)NLEJ247144320 DE-627 ger DE-627 rakwb Coagulation and fibrinolysis related cytokine imbalance in preeclampsia: the role of placental trophoblasts Walter de Gruyter 2009 2009 6 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier ©2009 by Walter de Gruyter Berlin New York Objective: Cytokine imbalance might have a pivotal role in hypercoagulability seen in preeclampsia. Our objective was to determine the relationship of blood coagulation related factors in placental tissue and peripheral blood in preeclamptic and normal pregnancies. Methods: We compared mRNA and protein levels of tissue-type plasminogen activator (t-PA), plasminogen activator inhibitor-1 (PAI-1), and tissue factor (TF) in the placenta of normal and preeclamptic pregnancies. Placental and peripheral blood t-PA and PAI-1 levels were examined. Trophoblasts were used to study the effects of hypoxia, hypoxia-reperfusion, and inflammatory cytokines on t-PA, PAI-1, tissue factor pathway inhibitor (TFPI), and TF. Results: PAI-1 and TF mRNA and protein levels were higher in placental tissue of preeclamptic pregnancies and in the peripheral blood of patients with preeclampsia. mRNA and protein secretion of TF, TFPI, PAI-1, but not t-PA, was increased in trophoblast cell culture under hypoxia and hypoxia-reoxygenation. Cell cultures with high levels of tumor necrosis factor-alpha (TNF-α) exhibited increased expression and secretion of TF and PAI-1, decreased TFPI, and no significant change of t-PA. Conclusions: Imbalanced synthesis of t-PA, PAI-1, TFPI, and TF in trophoblasts may contribute to hypercoagulability in patients with preeclampsia. Walter de Gruyter Online Zeitschriften Cytokines hypercoagulability preeclampsia Teng, Yin-Cheng oth Lin, Qi-De oth Lin, Jian-Hua oth Ding, Chuan-Wei oth Zuo, Ye oth Enthalten in Journal of perinatal medicine Berlin [u.a.] : de Gruyter, 1973 37(2009 2009), 4 vom: 17 17., Seite 343-348 (DE-627)NLEJ248236229 (DE-600)1467968-1 16193997 nnns volume:37 year:2009 2009 number:4 day:17 17 month:03 pages:343-348 extent:6 https://doi.org/10.1515/JPM.2009.060 Deutschlandweit zugänglich GBV_USEFLAG_U ZDB-1-DGR GBV_NL_ARTICLE AR 37 2009 2009 4 17 17 03 03 343-348 6 |
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coagulation and fibrinolysis related cytokine imbalance in preeclampsia: the role of placental trophoblasts |
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Coagulation and fibrinolysis related cytokine imbalance in preeclampsia: the role of placental trophoblasts |
| abstract |
Objective: Cytokine imbalance might have a pivotal role in hypercoagulability seen in preeclampsia. Our objective was to determine the relationship of blood coagulation related factors in placental tissue and peripheral blood in preeclamptic and normal pregnancies. Methods: We compared mRNA and protein levels of tissue-type plasminogen activator (t-PA), plasminogen activator inhibitor-1 (PAI-1), and tissue factor (TF) in the placenta of normal and preeclamptic pregnancies. Placental and peripheral blood t-PA and PAI-1 levels were examined. Trophoblasts were used to study the effects of hypoxia, hypoxia-reperfusion, and inflammatory cytokines on t-PA, PAI-1, tissue factor pathway inhibitor (TFPI), and TF. Results: PAI-1 and TF mRNA and protein levels were higher in placental tissue of preeclamptic pregnancies and in the peripheral blood of patients with preeclampsia. mRNA and protein secretion of TF, TFPI, PAI-1, but not t-PA, was increased in trophoblast cell culture under hypoxia and hypoxia-reoxygenation. Cell cultures with high levels of tumor necrosis factor-alpha (TNF-α) exhibited increased expression and secretion of TF and PAI-1, decreased TFPI, and no significant change of t-PA. Conclusions: Imbalanced synthesis of t-PA, PAI-1, TFPI, and TF in trophoblasts may contribute to hypercoagulability in patients with preeclampsia. ©2009 by Walter de Gruyter Berlin New York |
| abstractGer |
Objective: Cytokine imbalance might have a pivotal role in hypercoagulability seen in preeclampsia. Our objective was to determine the relationship of blood coagulation related factors in placental tissue and peripheral blood in preeclamptic and normal pregnancies. Methods: We compared mRNA and protein levels of tissue-type plasminogen activator (t-PA), plasminogen activator inhibitor-1 (PAI-1), and tissue factor (TF) in the placenta of normal and preeclamptic pregnancies. Placental and peripheral blood t-PA and PAI-1 levels were examined. Trophoblasts were used to study the effects of hypoxia, hypoxia-reperfusion, and inflammatory cytokines on t-PA, PAI-1, tissue factor pathway inhibitor (TFPI), and TF. Results: PAI-1 and TF mRNA and protein levels were higher in placental tissue of preeclamptic pregnancies and in the peripheral blood of patients with preeclampsia. mRNA and protein secretion of TF, TFPI, PAI-1, but not t-PA, was increased in trophoblast cell culture under hypoxia and hypoxia-reoxygenation. Cell cultures with high levels of tumor necrosis factor-alpha (TNF-α) exhibited increased expression and secretion of TF and PAI-1, decreased TFPI, and no significant change of t-PA. Conclusions: Imbalanced synthesis of t-PA, PAI-1, TFPI, and TF in trophoblasts may contribute to hypercoagulability in patients with preeclampsia. ©2009 by Walter de Gruyter Berlin New York |
| abstract_unstemmed |
Objective: Cytokine imbalance might have a pivotal role in hypercoagulability seen in preeclampsia. Our objective was to determine the relationship of blood coagulation related factors in placental tissue and peripheral blood in preeclamptic and normal pregnancies. Methods: We compared mRNA and protein levels of tissue-type plasminogen activator (t-PA), plasminogen activator inhibitor-1 (PAI-1), and tissue factor (TF) in the placenta of normal and preeclamptic pregnancies. Placental and peripheral blood t-PA and PAI-1 levels were examined. Trophoblasts were used to study the effects of hypoxia, hypoxia-reperfusion, and inflammatory cytokines on t-PA, PAI-1, tissue factor pathway inhibitor (TFPI), and TF. Results: PAI-1 and TF mRNA and protein levels were higher in placental tissue of preeclamptic pregnancies and in the peripheral blood of patients with preeclampsia. mRNA and protein secretion of TF, TFPI, PAI-1, but not t-PA, was increased in trophoblast cell culture under hypoxia and hypoxia-reoxygenation. Cell cultures with high levels of tumor necrosis factor-alpha (TNF-α) exhibited increased expression and secretion of TF and PAI-1, decreased TFPI, and no significant change of t-PA. Conclusions: Imbalanced synthesis of t-PA, PAI-1, TFPI, and TF in trophoblasts may contribute to hypercoagulability in patients with preeclampsia. ©2009 by Walter de Gruyter Berlin New York |
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| title_short |
Coagulation and fibrinolysis related cytokine imbalance in preeclampsia: the role of placental trophoblasts |
| url |
https://doi.org/10.1515/JPM.2009.060 |
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| author2 |
Teng, Yin-Cheng Lin, Qi-De Lin, Jian-Hua Ding, Chuan-Wei Zuo, Ye |
| author2Str |
Teng, Yin-Cheng Lin, Qi-De Lin, Jian-Hua Ding, Chuan-Wei Zuo, Ye |
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10.1515/JPM.2009.060 |
| up_date |
2024-07-06T10:04:21.784Z |
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