Persistent polar depletion of stratospheric ozone and emergent mechanisms of ultraviolet radiation-mediated health dysregulation
Year 2011 noted the first definable ozone “hole” in the Arctic region, serving as an indicator to the continued threat of dangerous ultraviolet radiation (UVR) exposure caused by the deterioration of stratospheric ozone in the northern hemisphere. Despite mandates of the Montreal Protocol to phase o...
Ausführliche Beschreibung
Gespeichert in:
| Autor*in: |
Dugo, Mark A. [verfasserIn] Han, Fengxiang [verfasserIn] Tchounwou, Paul B. [verfasserIn] |
|---|
| Format: |
E-Artikel |
|---|
| Erschienen: |
Walter de Gruyter ; 2012 |
|---|
| Schlagwörter: |
|---|
| Umfang: |
14 |
|---|
| Reproduktion: |
Walter de Gruyter Online Zeitschriften |
|---|---|
| Übergeordnetes Werk: |
Enthalten in: Reviews on environmental health - Berlin : de Gruyter, 1986, 27(2012), 2-3 vom: 11. Okt., Seite 103-116 |
| Übergeordnetes Werk: |
volume:27 ; year:2012 ; number:2-3 ; day:11 ; month:10 ; pages:103-116 ; extent:14 |
| Links: |
|---|
| DOI / URN: |
10.1515/reveh-2012-0026 |
|---|
| Katalog-ID: |
NLEJ247534552 |
|---|
| LEADER | 01000caa a22002652 4500 | ||
|---|---|---|---|
| 001 | NLEJ247534552 | ||
| 003 | DE-627 | ||
| 005 | 20220820032808.0 | ||
| 007 | cr uuu---uuuuu | ||
| 008 | 220814s2012 xx |||||o 00| ||und c | ||
| 024 | 7 | |a 10.1515/reveh-2012-0026 |2 doi | |
| 028 | 5 | 2 | |a artikel_Grundlieferung.pp |
| 035 | |a (DE-627)NLEJ247534552 | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rakwb | ||
| 100 | 1 | |a Dugo, Mark A. |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a Persistent polar depletion of stratospheric ozone and emergent mechanisms of ultraviolet radiation-mediated health dysregulation |
| 264 | 1 | |b Walter de Gruyter |c 2012 | |
| 300 | |a 14 | ||
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a Computermedien |b c |2 rdamedia | ||
| 338 | |a Online-Ressource |b cr |2 rdacarrier | ||
| 520 | |a Year 2011 noted the first definable ozone “hole” in the Arctic region, serving as an indicator to the continued threat of dangerous ultraviolet radiation (UVR) exposure caused by the deterioration of stratospheric ozone in the northern hemisphere. Despite mandates of the Montreal Protocol to phase out the production of ozone-depleting chemicals (ODCs), the relative stability of ODCs validates popular notions of persistent stratospheric ozone for several decades. Moreover, increased UVR exposure through stratospheric ozone depletion is occurring within a larger context of physiologic stress and climate change across the biosphere. In this review, we provide commentaries on stratospheric ozone depletion with relative comparisons between the well-known Antarctic ozone hole and the newly defined ozone hole in the Arctic. Compared with the Antarctic region, the increased UVR exposure in the Northern Hemisphere poses a threat to denser human populations across North America, Europe, and Asia. In this context, we discuss emerging targets of UVR exposure that can potentially offset normal biologic rhythms in terms of taxonomically conserved photoperiod-dependent seasonal signaling and entrainment of circadian clocks. Consequences of seasonal shifts during critical life history stages can alter fitness and condition, whereas circadian disruption is increasingly becoming associated as a causal link to increased carcinogenesis. We further review the significance of genomic alterations via UVR-induced modulations of phase I and II transcription factors located in skin cells, the aryl hydrocarbon receptor (AhR), and the nuclear factor (erythroid-derived 2)-related factor 2 (Nrf2), with emphasis on mechanism that can lead to metabolic shifts and cancer. Although concern for adverse health consequences due to increased UVR exposure are longstanding, recent advances in biochemical research suggest that AhR and Nrf2 transcriptional regulators are likely targets for UVR-mediated dysregulations of rhythmicity and homeostasis among animals, including humans. | ||
| 533 | |f Walter de Gruyter Online Zeitschriften | ||
| 650 | 4 | |a aryl hydrocarbon receptor (AhR) and nuclear factor (erythroid-derived 2)-related factor 2 (Nrf2) transcription factors | |
| 650 | 4 | |a biologic rhythmicity | |
| 650 | 4 | |a carcinogenicity | |
| 650 | 4 | |a climate change | |
| 650 | 4 | |a seasonal-circadian rhythms | |
| 650 | 4 | |a skin disorders | |
| 700 | 1 | |a Han, Fengxiang |e verfasserin |4 aut | |
| 700 | 1 | |a Tchounwou, Paul B. |e verfasserin |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |t Reviews on environmental health |d Berlin : de Gruyter, 1986 |g 27(2012), 2-3 vom: 11. Okt., Seite 103-116 |w (DE-627)NLEJ248236687 |w (DE-600)2609347-9 |x 2191-0308 |7 nnns |
| 773 | 1 | 8 | |g volume:27 |g year:2012 |g number:2-3 |g day:11 |g month:10 |g pages:103-116 |g extent:14 |
| 856 | 4 | 0 | |u https://doi.org/10.1515/reveh-2012-0026 |z Deutschlandweit zugänglich |
| 912 | |a GBV_USEFLAG_U | ||
| 912 | |a ZDB-1-DGR | ||
| 912 | |a GBV_NL_ARTICLE | ||
| 951 | |a AR | ||
| 952 | |d 27 |j 2012 |e 2-3 |b 11 |c 10 |h 103-116 |g 14 | ||
| author_variant |
m a d ma mad f h fh p b t pb pbt |
|---|---|
| matchkey_str |
article:21910308:2012----::essetoadpeinftaopeiooeneegnmcaimoutailtait |
| hierarchy_sort_str |
2012 |
| publishDate |
2012 |
| allfields |
10.1515/reveh-2012-0026 doi artikel_Grundlieferung.pp (DE-627)NLEJ247534552 DE-627 ger DE-627 rakwb Dugo, Mark A. verfasserin aut Persistent polar depletion of stratospheric ozone and emergent mechanisms of ultraviolet radiation-mediated health dysregulation Walter de Gruyter 2012 14 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Year 2011 noted the first definable ozone “hole” in the Arctic region, serving as an indicator to the continued threat of dangerous ultraviolet radiation (UVR) exposure caused by the deterioration of stratospheric ozone in the northern hemisphere. Despite mandates of the Montreal Protocol to phase out the production of ozone-depleting chemicals (ODCs), the relative stability of ODCs validates popular notions of persistent stratospheric ozone for several decades. Moreover, increased UVR exposure through stratospheric ozone depletion is occurring within a larger context of physiologic stress and climate change across the biosphere. In this review, we provide commentaries on stratospheric ozone depletion with relative comparisons between the well-known Antarctic ozone hole and the newly defined ozone hole in the Arctic. Compared with the Antarctic region, the increased UVR exposure in the Northern Hemisphere poses a threat to denser human populations across North America, Europe, and Asia. In this context, we discuss emerging targets of UVR exposure that can potentially offset normal biologic rhythms in terms of taxonomically conserved photoperiod-dependent seasonal signaling and entrainment of circadian clocks. Consequences of seasonal shifts during critical life history stages can alter fitness and condition, whereas circadian disruption is increasingly becoming associated as a causal link to increased carcinogenesis. We further review the significance of genomic alterations via UVR-induced modulations of phase I and II transcription factors located in skin cells, the aryl hydrocarbon receptor (AhR), and the nuclear factor (erythroid-derived 2)-related factor 2 (Nrf2), with emphasis on mechanism that can lead to metabolic shifts and cancer. Although concern for adverse health consequences due to increased UVR exposure are longstanding, recent advances in biochemical research suggest that AhR and Nrf2 transcriptional regulators are likely targets for UVR-mediated dysregulations of rhythmicity and homeostasis among animals, including humans. Walter de Gruyter Online Zeitschriften aryl hydrocarbon receptor (AhR) and nuclear factor (erythroid-derived 2)-related factor 2 (Nrf2) transcription factors biologic rhythmicity carcinogenicity climate change seasonal-circadian rhythms skin disorders Han, Fengxiang verfasserin aut Tchounwou, Paul B. verfasserin aut Enthalten in Reviews on environmental health Berlin : de Gruyter, 1986 27(2012), 2-3 vom: 11. Okt., Seite 103-116 (DE-627)NLEJ248236687 (DE-600)2609347-9 2191-0308 nnns volume:27 year:2012 number:2-3 day:11 month:10 pages:103-116 extent:14 https://doi.org/10.1515/reveh-2012-0026 Deutschlandweit zugänglich GBV_USEFLAG_U ZDB-1-DGR GBV_NL_ARTICLE AR 27 2012 2-3 11 10 103-116 14 |
| spelling |
10.1515/reveh-2012-0026 doi artikel_Grundlieferung.pp (DE-627)NLEJ247534552 DE-627 ger DE-627 rakwb Dugo, Mark A. verfasserin aut Persistent polar depletion of stratospheric ozone and emergent mechanisms of ultraviolet radiation-mediated health dysregulation Walter de Gruyter 2012 14 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Year 2011 noted the first definable ozone “hole” in the Arctic region, serving as an indicator to the continued threat of dangerous ultraviolet radiation (UVR) exposure caused by the deterioration of stratospheric ozone in the northern hemisphere. Despite mandates of the Montreal Protocol to phase out the production of ozone-depleting chemicals (ODCs), the relative stability of ODCs validates popular notions of persistent stratospheric ozone for several decades. Moreover, increased UVR exposure through stratospheric ozone depletion is occurring within a larger context of physiologic stress and climate change across the biosphere. In this review, we provide commentaries on stratospheric ozone depletion with relative comparisons between the well-known Antarctic ozone hole and the newly defined ozone hole in the Arctic. Compared with the Antarctic region, the increased UVR exposure in the Northern Hemisphere poses a threat to denser human populations across North America, Europe, and Asia. In this context, we discuss emerging targets of UVR exposure that can potentially offset normal biologic rhythms in terms of taxonomically conserved photoperiod-dependent seasonal signaling and entrainment of circadian clocks. Consequences of seasonal shifts during critical life history stages can alter fitness and condition, whereas circadian disruption is increasingly becoming associated as a causal link to increased carcinogenesis. We further review the significance of genomic alterations via UVR-induced modulations of phase I and II transcription factors located in skin cells, the aryl hydrocarbon receptor (AhR), and the nuclear factor (erythroid-derived 2)-related factor 2 (Nrf2), with emphasis on mechanism that can lead to metabolic shifts and cancer. Although concern for adverse health consequences due to increased UVR exposure are longstanding, recent advances in biochemical research suggest that AhR and Nrf2 transcriptional regulators are likely targets for UVR-mediated dysregulations of rhythmicity and homeostasis among animals, including humans. Walter de Gruyter Online Zeitschriften aryl hydrocarbon receptor (AhR) and nuclear factor (erythroid-derived 2)-related factor 2 (Nrf2) transcription factors biologic rhythmicity carcinogenicity climate change seasonal-circadian rhythms skin disorders Han, Fengxiang verfasserin aut Tchounwou, Paul B. verfasserin aut Enthalten in Reviews on environmental health Berlin : de Gruyter, 1986 27(2012), 2-3 vom: 11. Okt., Seite 103-116 (DE-627)NLEJ248236687 (DE-600)2609347-9 2191-0308 nnns volume:27 year:2012 number:2-3 day:11 month:10 pages:103-116 extent:14 https://doi.org/10.1515/reveh-2012-0026 Deutschlandweit zugänglich GBV_USEFLAG_U ZDB-1-DGR GBV_NL_ARTICLE AR 27 2012 2-3 11 10 103-116 14 |
| allfields_unstemmed |
10.1515/reveh-2012-0026 doi artikel_Grundlieferung.pp (DE-627)NLEJ247534552 DE-627 ger DE-627 rakwb Dugo, Mark A. verfasserin aut Persistent polar depletion of stratospheric ozone and emergent mechanisms of ultraviolet radiation-mediated health dysregulation Walter de Gruyter 2012 14 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Year 2011 noted the first definable ozone “hole” in the Arctic region, serving as an indicator to the continued threat of dangerous ultraviolet radiation (UVR) exposure caused by the deterioration of stratospheric ozone in the northern hemisphere. Despite mandates of the Montreal Protocol to phase out the production of ozone-depleting chemicals (ODCs), the relative stability of ODCs validates popular notions of persistent stratospheric ozone for several decades. Moreover, increased UVR exposure through stratospheric ozone depletion is occurring within a larger context of physiologic stress and climate change across the biosphere. In this review, we provide commentaries on stratospheric ozone depletion with relative comparisons between the well-known Antarctic ozone hole and the newly defined ozone hole in the Arctic. Compared with the Antarctic region, the increased UVR exposure in the Northern Hemisphere poses a threat to denser human populations across North America, Europe, and Asia. In this context, we discuss emerging targets of UVR exposure that can potentially offset normal biologic rhythms in terms of taxonomically conserved photoperiod-dependent seasonal signaling and entrainment of circadian clocks. Consequences of seasonal shifts during critical life history stages can alter fitness and condition, whereas circadian disruption is increasingly becoming associated as a causal link to increased carcinogenesis. We further review the significance of genomic alterations via UVR-induced modulations of phase I and II transcription factors located in skin cells, the aryl hydrocarbon receptor (AhR), and the nuclear factor (erythroid-derived 2)-related factor 2 (Nrf2), with emphasis on mechanism that can lead to metabolic shifts and cancer. Although concern for adverse health consequences due to increased UVR exposure are longstanding, recent advances in biochemical research suggest that AhR and Nrf2 transcriptional regulators are likely targets for UVR-mediated dysregulations of rhythmicity and homeostasis among animals, including humans. Walter de Gruyter Online Zeitschriften aryl hydrocarbon receptor (AhR) and nuclear factor (erythroid-derived 2)-related factor 2 (Nrf2) transcription factors biologic rhythmicity carcinogenicity climate change seasonal-circadian rhythms skin disorders Han, Fengxiang verfasserin aut Tchounwou, Paul B. verfasserin aut Enthalten in Reviews on environmental health Berlin : de Gruyter, 1986 27(2012), 2-3 vom: 11. Okt., Seite 103-116 (DE-627)NLEJ248236687 (DE-600)2609347-9 2191-0308 nnns volume:27 year:2012 number:2-3 day:11 month:10 pages:103-116 extent:14 https://doi.org/10.1515/reveh-2012-0026 Deutschlandweit zugänglich GBV_USEFLAG_U ZDB-1-DGR GBV_NL_ARTICLE AR 27 2012 2-3 11 10 103-116 14 |
| allfieldsGer |
10.1515/reveh-2012-0026 doi artikel_Grundlieferung.pp (DE-627)NLEJ247534552 DE-627 ger DE-627 rakwb Dugo, Mark A. verfasserin aut Persistent polar depletion of stratospheric ozone and emergent mechanisms of ultraviolet radiation-mediated health dysregulation Walter de Gruyter 2012 14 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Year 2011 noted the first definable ozone “hole” in the Arctic region, serving as an indicator to the continued threat of dangerous ultraviolet radiation (UVR) exposure caused by the deterioration of stratospheric ozone in the northern hemisphere. Despite mandates of the Montreal Protocol to phase out the production of ozone-depleting chemicals (ODCs), the relative stability of ODCs validates popular notions of persistent stratospheric ozone for several decades. Moreover, increased UVR exposure through stratospheric ozone depletion is occurring within a larger context of physiologic stress and climate change across the biosphere. In this review, we provide commentaries on stratospheric ozone depletion with relative comparisons between the well-known Antarctic ozone hole and the newly defined ozone hole in the Arctic. Compared with the Antarctic region, the increased UVR exposure in the Northern Hemisphere poses a threat to denser human populations across North America, Europe, and Asia. In this context, we discuss emerging targets of UVR exposure that can potentially offset normal biologic rhythms in terms of taxonomically conserved photoperiod-dependent seasonal signaling and entrainment of circadian clocks. Consequences of seasonal shifts during critical life history stages can alter fitness and condition, whereas circadian disruption is increasingly becoming associated as a causal link to increased carcinogenesis. We further review the significance of genomic alterations via UVR-induced modulations of phase I and II transcription factors located in skin cells, the aryl hydrocarbon receptor (AhR), and the nuclear factor (erythroid-derived 2)-related factor 2 (Nrf2), with emphasis on mechanism that can lead to metabolic shifts and cancer. Although concern for adverse health consequences due to increased UVR exposure are longstanding, recent advances in biochemical research suggest that AhR and Nrf2 transcriptional regulators are likely targets for UVR-mediated dysregulations of rhythmicity and homeostasis among animals, including humans. Walter de Gruyter Online Zeitschriften aryl hydrocarbon receptor (AhR) and nuclear factor (erythroid-derived 2)-related factor 2 (Nrf2) transcription factors biologic rhythmicity carcinogenicity climate change seasonal-circadian rhythms skin disorders Han, Fengxiang verfasserin aut Tchounwou, Paul B. verfasserin aut Enthalten in Reviews on environmental health Berlin : de Gruyter, 1986 27(2012), 2-3 vom: 11. Okt., Seite 103-116 (DE-627)NLEJ248236687 (DE-600)2609347-9 2191-0308 nnns volume:27 year:2012 number:2-3 day:11 month:10 pages:103-116 extent:14 https://doi.org/10.1515/reveh-2012-0026 Deutschlandweit zugänglich GBV_USEFLAG_U ZDB-1-DGR GBV_NL_ARTICLE AR 27 2012 2-3 11 10 103-116 14 |
| allfieldsSound |
10.1515/reveh-2012-0026 doi artikel_Grundlieferung.pp (DE-627)NLEJ247534552 DE-627 ger DE-627 rakwb Dugo, Mark A. verfasserin aut Persistent polar depletion of stratospheric ozone and emergent mechanisms of ultraviolet radiation-mediated health dysregulation Walter de Gruyter 2012 14 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Year 2011 noted the first definable ozone “hole” in the Arctic region, serving as an indicator to the continued threat of dangerous ultraviolet radiation (UVR) exposure caused by the deterioration of stratospheric ozone in the northern hemisphere. Despite mandates of the Montreal Protocol to phase out the production of ozone-depleting chemicals (ODCs), the relative stability of ODCs validates popular notions of persistent stratospheric ozone for several decades. Moreover, increased UVR exposure through stratospheric ozone depletion is occurring within a larger context of physiologic stress and climate change across the biosphere. In this review, we provide commentaries on stratospheric ozone depletion with relative comparisons between the well-known Antarctic ozone hole and the newly defined ozone hole in the Arctic. Compared with the Antarctic region, the increased UVR exposure in the Northern Hemisphere poses a threat to denser human populations across North America, Europe, and Asia. In this context, we discuss emerging targets of UVR exposure that can potentially offset normal biologic rhythms in terms of taxonomically conserved photoperiod-dependent seasonal signaling and entrainment of circadian clocks. Consequences of seasonal shifts during critical life history stages can alter fitness and condition, whereas circadian disruption is increasingly becoming associated as a causal link to increased carcinogenesis. We further review the significance of genomic alterations via UVR-induced modulations of phase I and II transcription factors located in skin cells, the aryl hydrocarbon receptor (AhR), and the nuclear factor (erythroid-derived 2)-related factor 2 (Nrf2), with emphasis on mechanism that can lead to metabolic shifts and cancer. Although concern for adverse health consequences due to increased UVR exposure are longstanding, recent advances in biochemical research suggest that AhR and Nrf2 transcriptional regulators are likely targets for UVR-mediated dysregulations of rhythmicity and homeostasis among animals, including humans. Walter de Gruyter Online Zeitschriften aryl hydrocarbon receptor (AhR) and nuclear factor (erythroid-derived 2)-related factor 2 (Nrf2) transcription factors biologic rhythmicity carcinogenicity climate change seasonal-circadian rhythms skin disorders Han, Fengxiang verfasserin aut Tchounwou, Paul B. verfasserin aut Enthalten in Reviews on environmental health Berlin : de Gruyter, 1986 27(2012), 2-3 vom: 11. Okt., Seite 103-116 (DE-627)NLEJ248236687 (DE-600)2609347-9 2191-0308 nnns volume:27 year:2012 number:2-3 day:11 month:10 pages:103-116 extent:14 https://doi.org/10.1515/reveh-2012-0026 Deutschlandweit zugänglich GBV_USEFLAG_U ZDB-1-DGR GBV_NL_ARTICLE AR 27 2012 2-3 11 10 103-116 14 |
| source |
Enthalten in Reviews on environmental health 27(2012), 2-3 vom: 11. Okt., Seite 103-116 volume:27 year:2012 number:2-3 day:11 month:10 pages:103-116 extent:14 |
| sourceStr |
Enthalten in Reviews on environmental health 27(2012), 2-3 vom: 11. Okt., Seite 103-116 volume:27 year:2012 number:2-3 day:11 month:10 pages:103-116 extent:14 |
| format_phy_str_mv |
Article |
| institution |
findex.gbv.de |
| topic_facet |
aryl hydrocarbon receptor (AhR) and nuclear factor (erythroid-derived 2)-related factor 2 (Nrf2) transcription factors biologic rhythmicity carcinogenicity climate change seasonal-circadian rhythms skin disorders |
| isfreeaccess_bool |
false |
| container_title |
Reviews on environmental health |
| authorswithroles_txt_mv |
Dugo, Mark A. @@aut@@ Han, Fengxiang @@aut@@ Tchounwou, Paul B. @@aut@@ |
| publishDateDaySort_date |
2012-10-11T00:00:00Z |
| hierarchy_top_id |
NLEJ248236687 |
| id |
NLEJ247534552 |
| fullrecord |
<?xml version="1.0" encoding="UTF-8"?><collection xmlns="http://www.loc.gov/MARC21/slim"><record><leader>01000caa a22002652 4500</leader><controlfield tag="001">NLEJ247534552</controlfield><controlfield tag="003">DE-627</controlfield><controlfield tag="005">20220820032808.0</controlfield><controlfield tag="007">cr uuu---uuuuu</controlfield><controlfield tag="008">220814s2012 xx |||||o 00| ||und c</controlfield><datafield tag="024" ind1="7" ind2=" "><subfield code="a">10.1515/reveh-2012-0026</subfield><subfield code="2">doi</subfield></datafield><datafield tag="028" ind1="5" ind2="2"><subfield code="a">artikel_Grundlieferung.pp</subfield></datafield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(DE-627)NLEJ247534552</subfield></datafield><datafield tag="040" ind1=" " ind2=" "><subfield code="a">DE-627</subfield><subfield code="b">ger</subfield><subfield code="c">DE-627</subfield><subfield code="e">rakwb</subfield></datafield><datafield tag="100" ind1="1" ind2=" "><subfield code="a">Dugo, Mark A.</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="245" ind1="1" ind2="0"><subfield code="a">Persistent polar depletion of stratospheric ozone and emergent mechanisms of ultraviolet radiation-mediated health dysregulation</subfield></datafield><datafield tag="264" ind1=" " ind2="1"><subfield code="b">Walter de Gruyter</subfield><subfield code="c">2012</subfield></datafield><datafield tag="300" ind1=" " ind2=" "><subfield code="a">14</subfield></datafield><datafield tag="336" ind1=" " ind2=" "><subfield code="a">Text</subfield><subfield code="b">txt</subfield><subfield code="2">rdacontent</subfield></datafield><datafield tag="337" ind1=" " ind2=" "><subfield code="a">Computermedien</subfield><subfield code="b">c</subfield><subfield code="2">rdamedia</subfield></datafield><datafield tag="338" ind1=" " ind2=" "><subfield code="a">Online-Ressource</subfield><subfield code="b">cr</subfield><subfield code="2">rdacarrier</subfield></datafield><datafield tag="520" ind1=" " ind2=" "><subfield code="a">Year 2011 noted the first definable ozone “hole” in the Arctic region, serving as an indicator to the continued threat of dangerous ultraviolet radiation (UVR) exposure caused by the deterioration of stratospheric ozone in the northern hemisphere. Despite mandates of the Montreal Protocol to phase out the production of ozone-depleting chemicals (ODCs), the relative stability of ODCs validates popular notions of persistent stratospheric ozone for several decades. Moreover, increased UVR exposure through stratospheric ozone depletion is occurring within a larger context of physiologic stress and climate change across the biosphere. In this review, we provide commentaries on stratospheric ozone depletion with relative comparisons between the well-known Antarctic ozone hole and the newly defined ozone hole in the Arctic. Compared with the Antarctic region, the increased UVR exposure in the Northern Hemisphere poses a threat to denser human populations across North America, Europe, and Asia. In this context, we discuss emerging targets of UVR exposure that can potentially offset normal biologic rhythms in terms of taxonomically conserved photoperiod-dependent seasonal signaling and entrainment of circadian clocks. Consequences of seasonal shifts during critical life history stages can alter fitness and condition, whereas circadian disruption is increasingly becoming associated as a causal link to increased carcinogenesis. We further review the significance of genomic alterations via UVR-induced modulations of phase I and II transcription factors located in skin cells, the aryl hydrocarbon receptor (AhR), and the nuclear factor (erythroid-derived 2)-related factor 2 (Nrf2), with emphasis on mechanism that can lead to metabolic shifts and cancer. Although concern for adverse health consequences due to increased UVR exposure are longstanding, recent advances in biochemical research suggest that AhR and Nrf2 transcriptional regulators are likely targets for UVR-mediated dysregulations of rhythmicity and homeostasis among animals, including humans.</subfield></datafield><datafield tag="533" ind1=" " ind2=" "><subfield code="f">Walter de Gruyter Online Zeitschriften</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">aryl hydrocarbon receptor (AhR) and nuclear factor (erythroid-derived 2)-related factor 2 (Nrf2) transcription factors</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">biologic rhythmicity</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">carcinogenicity</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">climate change</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">seasonal-circadian rhythms</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">skin disorders</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Han, Fengxiang</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Tchounwou, Paul B.</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="773" ind1="0" ind2="8"><subfield code="i">Enthalten in</subfield><subfield code="t">Reviews on environmental health</subfield><subfield code="d">Berlin : de Gruyter, 1986</subfield><subfield code="g">27(2012), 2-3 vom: 11. Okt., Seite 103-116</subfield><subfield code="w">(DE-627)NLEJ248236687</subfield><subfield code="w">(DE-600)2609347-9</subfield><subfield code="x">2191-0308</subfield><subfield code="7">nnns</subfield></datafield><datafield tag="773" ind1="1" ind2="8"><subfield code="g">volume:27</subfield><subfield code="g">year:2012</subfield><subfield code="g">number:2-3</subfield><subfield code="g">day:11</subfield><subfield code="g">month:10</subfield><subfield code="g">pages:103-116</subfield><subfield code="g">extent:14</subfield></datafield><datafield tag="856" ind1="4" ind2="0"><subfield code="u">https://doi.org/10.1515/reveh-2012-0026</subfield><subfield code="z">Deutschlandweit zugänglich</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_USEFLAG_U</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">ZDB-1-DGR</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_NL_ARTICLE</subfield></datafield><datafield tag="951" ind1=" " ind2=" "><subfield code="a">AR</subfield></datafield><datafield tag="952" ind1=" " ind2=" "><subfield code="d">27</subfield><subfield code="j">2012</subfield><subfield code="e">2-3</subfield><subfield code="b">11</subfield><subfield code="c">10</subfield><subfield code="h">103-116</subfield><subfield code="g">14</subfield></datafield></record></collection>
|
| series2 |
Walter de Gruyter Online Zeitschriften |
| author |
Dugo, Mark A. |
| spellingShingle |
Dugo, Mark A. misc aryl hydrocarbon receptor (AhR) and nuclear factor (erythroid-derived 2)-related factor 2 (Nrf2) transcription factors misc biologic rhythmicity misc carcinogenicity misc climate change misc seasonal-circadian rhythms misc skin disorders Persistent polar depletion of stratospheric ozone and emergent mechanisms of ultraviolet radiation-mediated health dysregulation |
| authorStr |
Dugo, Mark A. |
| ppnlink_with_tag_str_mv |
@@773@@(DE-627)NLEJ248236687 |
| format |
electronic Article |
| delete_txt_mv |
keep |
| author_role |
aut aut aut |
| collection |
NL |
| remote_str |
true |
| illustrated |
Not Illustrated |
| issn |
2191-0308 |
| topic_title |
Persistent polar depletion of stratospheric ozone and emergent mechanisms of ultraviolet radiation-mediated health dysregulation aryl hydrocarbon receptor (AhR) and nuclear factor (erythroid-derived 2)-related factor 2 (Nrf2) transcription factors biologic rhythmicity carcinogenicity climate change seasonal-circadian rhythms skin disorders |
| publisher |
Walter de Gruyter |
| publisherStr |
Walter de Gruyter |
| topic |
misc aryl hydrocarbon receptor (AhR) and nuclear factor (erythroid-derived 2)-related factor 2 (Nrf2) transcription factors misc biologic rhythmicity misc carcinogenicity misc climate change misc seasonal-circadian rhythms misc skin disorders |
| topic_unstemmed |
misc aryl hydrocarbon receptor (AhR) and nuclear factor (erythroid-derived 2)-related factor 2 (Nrf2) transcription factors misc biologic rhythmicity misc carcinogenicity misc climate change misc seasonal-circadian rhythms misc skin disorders |
| topic_browse |
misc aryl hydrocarbon receptor (AhR) and nuclear factor (erythroid-derived 2)-related factor 2 (Nrf2) transcription factors misc biologic rhythmicity misc carcinogenicity misc climate change misc seasonal-circadian rhythms misc skin disorders |
| format_facet |
Elektronische Aufsätze Aufsätze Elektronische Ressource |
| format_main_str_mv |
Text Zeitschrift/Artikel |
| carriertype_str_mv |
cr |
| hierarchy_parent_title |
Reviews on environmental health |
| hierarchy_parent_id |
NLEJ248236687 |
| hierarchy_top_title |
Reviews on environmental health |
| isfreeaccess_txt |
false |
| familylinks_str_mv |
(DE-627)NLEJ248236687 (DE-600)2609347-9 |
| title |
Persistent polar depletion of stratospheric ozone and emergent mechanisms of ultraviolet radiation-mediated health dysregulation |
| ctrlnum |
(DE-627)NLEJ247534552 |
| title_full |
Persistent polar depletion of stratospheric ozone and emergent mechanisms of ultraviolet radiation-mediated health dysregulation |
| author_sort |
Dugo, Mark A. |
| journal |
Reviews on environmental health |
| journalStr |
Reviews on environmental health |
| isOA_bool |
false |
| recordtype |
marc |
| publishDateSort |
2012 |
| contenttype_str_mv |
txt |
| container_start_page |
103 |
| author_browse |
Dugo, Mark A. Han, Fengxiang Tchounwou, Paul B. |
| container_volume |
27 |
| physical |
14 |
| format_se |
Elektronische Aufsätze |
| author-letter |
Dugo, Mark A. |
| doi_str_mv |
10.1515/reveh-2012-0026 |
| author2-role |
verfasserin |
| title_sort |
persistent polar depletion of stratospheric ozone and emergent mechanisms of ultraviolet radiation-mediated health dysregulation |
| title_auth |
Persistent polar depletion of stratospheric ozone and emergent mechanisms of ultraviolet radiation-mediated health dysregulation |
| abstract |
Year 2011 noted the first definable ozone “hole” in the Arctic region, serving as an indicator to the continued threat of dangerous ultraviolet radiation (UVR) exposure caused by the deterioration of stratospheric ozone in the northern hemisphere. Despite mandates of the Montreal Protocol to phase out the production of ozone-depleting chemicals (ODCs), the relative stability of ODCs validates popular notions of persistent stratospheric ozone for several decades. Moreover, increased UVR exposure through stratospheric ozone depletion is occurring within a larger context of physiologic stress and climate change across the biosphere. In this review, we provide commentaries on stratospheric ozone depletion with relative comparisons between the well-known Antarctic ozone hole and the newly defined ozone hole in the Arctic. Compared with the Antarctic region, the increased UVR exposure in the Northern Hemisphere poses a threat to denser human populations across North America, Europe, and Asia. In this context, we discuss emerging targets of UVR exposure that can potentially offset normal biologic rhythms in terms of taxonomically conserved photoperiod-dependent seasonal signaling and entrainment of circadian clocks. Consequences of seasonal shifts during critical life history stages can alter fitness and condition, whereas circadian disruption is increasingly becoming associated as a causal link to increased carcinogenesis. We further review the significance of genomic alterations via UVR-induced modulations of phase I and II transcription factors located in skin cells, the aryl hydrocarbon receptor (AhR), and the nuclear factor (erythroid-derived 2)-related factor 2 (Nrf2), with emphasis on mechanism that can lead to metabolic shifts and cancer. Although concern for adverse health consequences due to increased UVR exposure are longstanding, recent advances in biochemical research suggest that AhR and Nrf2 transcriptional regulators are likely targets for UVR-mediated dysregulations of rhythmicity and homeostasis among animals, including humans. |
| abstractGer |
Year 2011 noted the first definable ozone “hole” in the Arctic region, serving as an indicator to the continued threat of dangerous ultraviolet radiation (UVR) exposure caused by the deterioration of stratospheric ozone in the northern hemisphere. Despite mandates of the Montreal Protocol to phase out the production of ozone-depleting chemicals (ODCs), the relative stability of ODCs validates popular notions of persistent stratospheric ozone for several decades. Moreover, increased UVR exposure through stratospheric ozone depletion is occurring within a larger context of physiologic stress and climate change across the biosphere. In this review, we provide commentaries on stratospheric ozone depletion with relative comparisons between the well-known Antarctic ozone hole and the newly defined ozone hole in the Arctic. Compared with the Antarctic region, the increased UVR exposure in the Northern Hemisphere poses a threat to denser human populations across North America, Europe, and Asia. In this context, we discuss emerging targets of UVR exposure that can potentially offset normal biologic rhythms in terms of taxonomically conserved photoperiod-dependent seasonal signaling and entrainment of circadian clocks. Consequences of seasonal shifts during critical life history stages can alter fitness and condition, whereas circadian disruption is increasingly becoming associated as a causal link to increased carcinogenesis. We further review the significance of genomic alterations via UVR-induced modulations of phase I and II transcription factors located in skin cells, the aryl hydrocarbon receptor (AhR), and the nuclear factor (erythroid-derived 2)-related factor 2 (Nrf2), with emphasis on mechanism that can lead to metabolic shifts and cancer. Although concern for adverse health consequences due to increased UVR exposure are longstanding, recent advances in biochemical research suggest that AhR and Nrf2 transcriptional regulators are likely targets for UVR-mediated dysregulations of rhythmicity and homeostasis among animals, including humans. |
| abstract_unstemmed |
Year 2011 noted the first definable ozone “hole” in the Arctic region, serving as an indicator to the continued threat of dangerous ultraviolet radiation (UVR) exposure caused by the deterioration of stratospheric ozone in the northern hemisphere. Despite mandates of the Montreal Protocol to phase out the production of ozone-depleting chemicals (ODCs), the relative stability of ODCs validates popular notions of persistent stratospheric ozone for several decades. Moreover, increased UVR exposure through stratospheric ozone depletion is occurring within a larger context of physiologic stress and climate change across the biosphere. In this review, we provide commentaries on stratospheric ozone depletion with relative comparisons between the well-known Antarctic ozone hole and the newly defined ozone hole in the Arctic. Compared with the Antarctic region, the increased UVR exposure in the Northern Hemisphere poses a threat to denser human populations across North America, Europe, and Asia. In this context, we discuss emerging targets of UVR exposure that can potentially offset normal biologic rhythms in terms of taxonomically conserved photoperiod-dependent seasonal signaling and entrainment of circadian clocks. Consequences of seasonal shifts during critical life history stages can alter fitness and condition, whereas circadian disruption is increasingly becoming associated as a causal link to increased carcinogenesis. We further review the significance of genomic alterations via UVR-induced modulations of phase I and II transcription factors located in skin cells, the aryl hydrocarbon receptor (AhR), and the nuclear factor (erythroid-derived 2)-related factor 2 (Nrf2), with emphasis on mechanism that can lead to metabolic shifts and cancer. Although concern for adverse health consequences due to increased UVR exposure are longstanding, recent advances in biochemical research suggest that AhR and Nrf2 transcriptional regulators are likely targets for UVR-mediated dysregulations of rhythmicity and homeostasis among animals, including humans. |
| collection_details |
GBV_USEFLAG_U ZDB-1-DGR GBV_NL_ARTICLE |
| container_issue |
2-3 |
| title_short |
Persistent polar depletion of stratospheric ozone and emergent mechanisms of ultraviolet radiation-mediated health dysregulation |
| url |
https://doi.org/10.1515/reveh-2012-0026 |
| remote_bool |
true |
| author2 |
Han, Fengxiang Tchounwou, Paul B. |
| author2Str |
Han, Fengxiang Tchounwou, Paul B. |
| ppnlink |
NLEJ248236687 |
| mediatype_str_mv |
c |
| isOA_txt |
false |
| hochschulschrift_bool |
false |
| doi_str |
10.1515/reveh-2012-0026 |
| up_date |
2024-07-06T10:43:51.517Z |
| _version_ |
1803826109106618368 |
| fullrecord_marcxml |
<?xml version="1.0" encoding="UTF-8"?><collection xmlns="http://www.loc.gov/MARC21/slim"><record><leader>01000caa a22002652 4500</leader><controlfield tag="001">NLEJ247534552</controlfield><controlfield tag="003">DE-627</controlfield><controlfield tag="005">20220820032808.0</controlfield><controlfield tag="007">cr uuu---uuuuu</controlfield><controlfield tag="008">220814s2012 xx |||||o 00| ||und c</controlfield><datafield tag="024" ind1="7" ind2=" "><subfield code="a">10.1515/reveh-2012-0026</subfield><subfield code="2">doi</subfield></datafield><datafield tag="028" ind1="5" ind2="2"><subfield code="a">artikel_Grundlieferung.pp</subfield></datafield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(DE-627)NLEJ247534552</subfield></datafield><datafield tag="040" ind1=" " ind2=" "><subfield code="a">DE-627</subfield><subfield code="b">ger</subfield><subfield code="c">DE-627</subfield><subfield code="e">rakwb</subfield></datafield><datafield tag="100" ind1="1" ind2=" "><subfield code="a">Dugo, Mark A.</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="245" ind1="1" ind2="0"><subfield code="a">Persistent polar depletion of stratospheric ozone and emergent mechanisms of ultraviolet radiation-mediated health dysregulation</subfield></datafield><datafield tag="264" ind1=" " ind2="1"><subfield code="b">Walter de Gruyter</subfield><subfield code="c">2012</subfield></datafield><datafield tag="300" ind1=" " ind2=" "><subfield code="a">14</subfield></datafield><datafield tag="336" ind1=" " ind2=" "><subfield code="a">Text</subfield><subfield code="b">txt</subfield><subfield code="2">rdacontent</subfield></datafield><datafield tag="337" ind1=" " ind2=" "><subfield code="a">Computermedien</subfield><subfield code="b">c</subfield><subfield code="2">rdamedia</subfield></datafield><datafield tag="338" ind1=" " ind2=" "><subfield code="a">Online-Ressource</subfield><subfield code="b">cr</subfield><subfield code="2">rdacarrier</subfield></datafield><datafield tag="520" ind1=" " ind2=" "><subfield code="a">Year 2011 noted the first definable ozone “hole” in the Arctic region, serving as an indicator to the continued threat of dangerous ultraviolet radiation (UVR) exposure caused by the deterioration of stratospheric ozone in the northern hemisphere. Despite mandates of the Montreal Protocol to phase out the production of ozone-depleting chemicals (ODCs), the relative stability of ODCs validates popular notions of persistent stratospheric ozone for several decades. Moreover, increased UVR exposure through stratospheric ozone depletion is occurring within a larger context of physiologic stress and climate change across the biosphere. In this review, we provide commentaries on stratospheric ozone depletion with relative comparisons between the well-known Antarctic ozone hole and the newly defined ozone hole in the Arctic. Compared with the Antarctic region, the increased UVR exposure in the Northern Hemisphere poses a threat to denser human populations across North America, Europe, and Asia. In this context, we discuss emerging targets of UVR exposure that can potentially offset normal biologic rhythms in terms of taxonomically conserved photoperiod-dependent seasonal signaling and entrainment of circadian clocks. Consequences of seasonal shifts during critical life history stages can alter fitness and condition, whereas circadian disruption is increasingly becoming associated as a causal link to increased carcinogenesis. We further review the significance of genomic alterations via UVR-induced modulations of phase I and II transcription factors located in skin cells, the aryl hydrocarbon receptor (AhR), and the nuclear factor (erythroid-derived 2)-related factor 2 (Nrf2), with emphasis on mechanism that can lead to metabolic shifts and cancer. Although concern for adverse health consequences due to increased UVR exposure are longstanding, recent advances in biochemical research suggest that AhR and Nrf2 transcriptional regulators are likely targets for UVR-mediated dysregulations of rhythmicity and homeostasis among animals, including humans.</subfield></datafield><datafield tag="533" ind1=" " ind2=" "><subfield code="f">Walter de Gruyter Online Zeitschriften</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">aryl hydrocarbon receptor (AhR) and nuclear factor (erythroid-derived 2)-related factor 2 (Nrf2) transcription factors</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">biologic rhythmicity</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">carcinogenicity</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">climate change</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">seasonal-circadian rhythms</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">skin disorders</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Han, Fengxiang</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Tchounwou, Paul B.</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="773" ind1="0" ind2="8"><subfield code="i">Enthalten in</subfield><subfield code="t">Reviews on environmental health</subfield><subfield code="d">Berlin : de Gruyter, 1986</subfield><subfield code="g">27(2012), 2-3 vom: 11. Okt., Seite 103-116</subfield><subfield code="w">(DE-627)NLEJ248236687</subfield><subfield code="w">(DE-600)2609347-9</subfield><subfield code="x">2191-0308</subfield><subfield code="7">nnns</subfield></datafield><datafield tag="773" ind1="1" ind2="8"><subfield code="g">volume:27</subfield><subfield code="g">year:2012</subfield><subfield code="g">number:2-3</subfield><subfield code="g">day:11</subfield><subfield code="g">month:10</subfield><subfield code="g">pages:103-116</subfield><subfield code="g">extent:14</subfield></datafield><datafield tag="856" ind1="4" ind2="0"><subfield code="u">https://doi.org/10.1515/reveh-2012-0026</subfield><subfield code="z">Deutschlandweit zugänglich</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_USEFLAG_U</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">ZDB-1-DGR</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_NL_ARTICLE</subfield></datafield><datafield tag="951" ind1=" " ind2=" "><subfield code="a">AR</subfield></datafield><datafield tag="952" ind1=" " ind2=" "><subfield code="d">27</subfield><subfield code="j">2012</subfield><subfield code="e">2-3</subfield><subfield code="b">11</subfield><subfield code="c">10</subfield><subfield code="h">103-116</subfield><subfield code="g">14</subfield></datafield></record></collection>
|
| score |
7.4006968 |