Molecular brake pad hypothesis: pulling off the brakes for emotional memory
Under basal conditions histone deacetylases (HDACs) and their associated co-repressor complexes serve as molecular ‘brake pads’ to prevent the gene expression required for long-term memory formation. Following a learning event, HDACs and their co-repressor complexes are removed from a subset of spec...
Ausführliche Beschreibung
Gespeichert in:
| Autor*in: |
Vogel-Ciernia, Annie [verfasserIn] Wood, Marcelo A. [verfasserIn] |
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E-Artikel |
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| Erschienen: |
De Gruyter ; 2012 |
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| Schlagwörter: |
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| Umfang: |
20 |
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| Reproduktion: |
Walter de Gruyter Online Zeitschriften |
|---|---|
| Übergeordnetes Werk: |
Enthalten in: Reviews in the neurosciences - Berlin : de Gruyter, 1987, 23(2012), 5-6 vom: 24. Aug., Seite 607-626 |
| Übergeordnetes Werk: |
volume:23 ; year:2012 ; number:5-6 ; day:24 ; month:08 ; pages:607-626 ; extent:20 |
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| DOI / URN: |
10.1515/revneuro-2012-0050 |
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| 520 | |a Under basal conditions histone deacetylases (HDACs) and their associated co-repressor complexes serve as molecular ‘brake pads’ to prevent the gene expression required for long-term memory formation. Following a learning event, HDACs and their co-repressor complexes are removed from a subset of specific gene promoters, allowing the histone acetylation and active gene expression required for long-term memory formation. Inhibition of HDACs increases histone acetylation, extends gene expression profiles, and allows for the formation of persistent long-term memories for training events that are otherwise forgotten. We propose that emotionally salient experiences have utilized this system to form strong and persistent memories for behaviorally significant events. Consequently, the presence or absence of HDACs at a selection of specific gene promoters could serve as a critical barrier for permitting the formation of long-term memories. | ||
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10.1515/revneuro-2012-0050 doi artikel_Grundlieferung.pp (DE-627)NLEJ247535370 DE-627 ger DE-627 rakwb Vogel-Ciernia, Annie verfasserin aut Molecular brake pad hypothesis: pulling off the brakes for emotional memory De Gruyter 2012 20 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Under basal conditions histone deacetylases (HDACs) and their associated co-repressor complexes serve as molecular ‘brake pads’ to prevent the gene expression required for long-term memory formation. Following a learning event, HDACs and their co-repressor complexes are removed from a subset of specific gene promoters, allowing the histone acetylation and active gene expression required for long-term memory formation. Inhibition of HDACs increases histone acetylation, extends gene expression profiles, and allows for the formation of persistent long-term memories for training events that are otherwise forgotten. We propose that emotionally salient experiences have utilized this system to form strong and persistent memories for behaviorally significant events. Consequently, the presence or absence of HDACs at a selection of specific gene promoters could serve as a critical barrier for permitting the formation of long-term memories. Walter de Gruyter Online Zeitschriften chromatin epigenetics gene expression glucocorticoids histone acetylation histone deacetylases (HDACs) Wood, Marcelo A. verfasserin aut Enthalten in Reviews in the neurosciences Berlin : de Gruyter, 1987 23(2012), 5-6 vom: 24. Aug., Seite 607-626 (DE-627)NLEJ248236709 (DE-600)2598365-9 2191-0200 nnns volume:23 year:2012 number:5-6 day:24 month:08 pages:607-626 extent:20 https://doi.org/10.1515/revneuro-2012-0050 Deutschlandweit zugänglich GBV_USEFLAG_U ZDB-1-DGR GBV_NL_ARTICLE AR 23 2012 5-6 24 08 607-626 20 |
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10.1515/revneuro-2012-0050 doi artikel_Grundlieferung.pp (DE-627)NLEJ247535370 DE-627 ger DE-627 rakwb Vogel-Ciernia, Annie verfasserin aut Molecular brake pad hypothesis: pulling off the brakes for emotional memory De Gruyter 2012 20 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Under basal conditions histone deacetylases (HDACs) and their associated co-repressor complexes serve as molecular ‘brake pads’ to prevent the gene expression required for long-term memory formation. Following a learning event, HDACs and their co-repressor complexes are removed from a subset of specific gene promoters, allowing the histone acetylation and active gene expression required for long-term memory formation. Inhibition of HDACs increases histone acetylation, extends gene expression profiles, and allows for the formation of persistent long-term memories for training events that are otherwise forgotten. We propose that emotionally salient experiences have utilized this system to form strong and persistent memories for behaviorally significant events. Consequently, the presence or absence of HDACs at a selection of specific gene promoters could serve as a critical barrier for permitting the formation of long-term memories. Walter de Gruyter Online Zeitschriften chromatin epigenetics gene expression glucocorticoids histone acetylation histone deacetylases (HDACs) Wood, Marcelo A. verfasserin aut Enthalten in Reviews in the neurosciences Berlin : de Gruyter, 1987 23(2012), 5-6 vom: 24. Aug., Seite 607-626 (DE-627)NLEJ248236709 (DE-600)2598365-9 2191-0200 nnns volume:23 year:2012 number:5-6 day:24 month:08 pages:607-626 extent:20 https://doi.org/10.1515/revneuro-2012-0050 Deutschlandweit zugänglich GBV_USEFLAG_U ZDB-1-DGR GBV_NL_ARTICLE AR 23 2012 5-6 24 08 607-626 20 |
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10.1515/revneuro-2012-0050 doi artikel_Grundlieferung.pp (DE-627)NLEJ247535370 DE-627 ger DE-627 rakwb Vogel-Ciernia, Annie verfasserin aut Molecular brake pad hypothesis: pulling off the brakes for emotional memory De Gruyter 2012 20 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Under basal conditions histone deacetylases (HDACs) and their associated co-repressor complexes serve as molecular ‘brake pads’ to prevent the gene expression required for long-term memory formation. Following a learning event, HDACs and their co-repressor complexes are removed from a subset of specific gene promoters, allowing the histone acetylation and active gene expression required for long-term memory formation. Inhibition of HDACs increases histone acetylation, extends gene expression profiles, and allows for the formation of persistent long-term memories for training events that are otherwise forgotten. We propose that emotionally salient experiences have utilized this system to form strong and persistent memories for behaviorally significant events. Consequently, the presence or absence of HDACs at a selection of specific gene promoters could serve as a critical barrier for permitting the formation of long-term memories. Walter de Gruyter Online Zeitschriften chromatin epigenetics gene expression glucocorticoids histone acetylation histone deacetylases (HDACs) Wood, Marcelo A. verfasserin aut Enthalten in Reviews in the neurosciences Berlin : de Gruyter, 1987 23(2012), 5-6 vom: 24. Aug., Seite 607-626 (DE-627)NLEJ248236709 (DE-600)2598365-9 2191-0200 nnns volume:23 year:2012 number:5-6 day:24 month:08 pages:607-626 extent:20 https://doi.org/10.1515/revneuro-2012-0050 Deutschlandweit zugänglich GBV_USEFLAG_U ZDB-1-DGR GBV_NL_ARTICLE AR 23 2012 5-6 24 08 607-626 20 |
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10.1515/revneuro-2012-0050 doi artikel_Grundlieferung.pp (DE-627)NLEJ247535370 DE-627 ger DE-627 rakwb Vogel-Ciernia, Annie verfasserin aut Molecular brake pad hypothesis: pulling off the brakes for emotional memory De Gruyter 2012 20 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Under basal conditions histone deacetylases (HDACs) and their associated co-repressor complexes serve as molecular ‘brake pads’ to prevent the gene expression required for long-term memory formation. Following a learning event, HDACs and their co-repressor complexes are removed from a subset of specific gene promoters, allowing the histone acetylation and active gene expression required for long-term memory formation. Inhibition of HDACs increases histone acetylation, extends gene expression profiles, and allows for the formation of persistent long-term memories for training events that are otherwise forgotten. We propose that emotionally salient experiences have utilized this system to form strong and persistent memories for behaviorally significant events. Consequently, the presence or absence of HDACs at a selection of specific gene promoters could serve as a critical barrier for permitting the formation of long-term memories. Walter de Gruyter Online Zeitschriften chromatin epigenetics gene expression glucocorticoids histone acetylation histone deacetylases (HDACs) Wood, Marcelo A. verfasserin aut Enthalten in Reviews in the neurosciences Berlin : de Gruyter, 1987 23(2012), 5-6 vom: 24. Aug., Seite 607-626 (DE-627)NLEJ248236709 (DE-600)2598365-9 2191-0200 nnns volume:23 year:2012 number:5-6 day:24 month:08 pages:607-626 extent:20 https://doi.org/10.1515/revneuro-2012-0050 Deutschlandweit zugänglich GBV_USEFLAG_U ZDB-1-DGR GBV_NL_ARTICLE AR 23 2012 5-6 24 08 607-626 20 |
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10.1515/revneuro-2012-0050 doi artikel_Grundlieferung.pp (DE-627)NLEJ247535370 DE-627 ger DE-627 rakwb Vogel-Ciernia, Annie verfasserin aut Molecular brake pad hypothesis: pulling off the brakes for emotional memory De Gruyter 2012 20 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Under basal conditions histone deacetylases (HDACs) and their associated co-repressor complexes serve as molecular ‘brake pads’ to prevent the gene expression required for long-term memory formation. Following a learning event, HDACs and their co-repressor complexes are removed from a subset of specific gene promoters, allowing the histone acetylation and active gene expression required for long-term memory formation. Inhibition of HDACs increases histone acetylation, extends gene expression profiles, and allows for the formation of persistent long-term memories for training events that are otherwise forgotten. We propose that emotionally salient experiences have utilized this system to form strong and persistent memories for behaviorally significant events. Consequently, the presence or absence of HDACs at a selection of specific gene promoters could serve as a critical barrier for permitting the formation of long-term memories. Walter de Gruyter Online Zeitschriften chromatin epigenetics gene expression glucocorticoids histone acetylation histone deacetylases (HDACs) Wood, Marcelo A. verfasserin aut Enthalten in Reviews in the neurosciences Berlin : de Gruyter, 1987 23(2012), 5-6 vom: 24. Aug., Seite 607-626 (DE-627)NLEJ248236709 (DE-600)2598365-9 2191-0200 nnns volume:23 year:2012 number:5-6 day:24 month:08 pages:607-626 extent:20 https://doi.org/10.1515/revneuro-2012-0050 Deutschlandweit zugänglich GBV_USEFLAG_U ZDB-1-DGR GBV_NL_ARTICLE AR 23 2012 5-6 24 08 607-626 20 |
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Under basal conditions histone deacetylases (HDACs) and their associated co-repressor complexes serve as molecular ‘brake pads’ to prevent the gene expression required for long-term memory formation. Following a learning event, HDACs and their co-repressor complexes are removed from a subset of specific gene promoters, allowing the histone acetylation and active gene expression required for long-term memory formation. Inhibition of HDACs increases histone acetylation, extends gene expression profiles, and allows for the formation of persistent long-term memories for training events that are otherwise forgotten. We propose that emotionally salient experiences have utilized this system to form strong and persistent memories for behaviorally significant events. Consequently, the presence or absence of HDACs at a selection of specific gene promoters could serve as a critical barrier for permitting the formation of long-term memories. |
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Under basal conditions histone deacetylases (HDACs) and their associated co-repressor complexes serve as molecular ‘brake pads’ to prevent the gene expression required for long-term memory formation. Following a learning event, HDACs and their co-repressor complexes are removed from a subset of specific gene promoters, allowing the histone acetylation and active gene expression required for long-term memory formation. Inhibition of HDACs increases histone acetylation, extends gene expression profiles, and allows for the formation of persistent long-term memories for training events that are otherwise forgotten. We propose that emotionally salient experiences have utilized this system to form strong and persistent memories for behaviorally significant events. Consequently, the presence or absence of HDACs at a selection of specific gene promoters could serve as a critical barrier for permitting the formation of long-term memories. |
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Under basal conditions histone deacetylases (HDACs) and their associated co-repressor complexes serve as molecular ‘brake pads’ to prevent the gene expression required for long-term memory formation. Following a learning event, HDACs and their co-repressor complexes are removed from a subset of specific gene promoters, allowing the histone acetylation and active gene expression required for long-term memory formation. Inhibition of HDACs increases histone acetylation, extends gene expression profiles, and allows for the formation of persistent long-term memories for training events that are otherwise forgotten. We propose that emotionally salient experiences have utilized this system to form strong and persistent memories for behaviorally significant events. Consequently, the presence or absence of HDACs at a selection of specific gene promoters could serve as a critical barrier for permitting the formation of long-term memories. |
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<?xml version="1.0" encoding="UTF-8"?><collection xmlns="http://www.loc.gov/MARC21/slim"><record><leader>01000caa a22002652 4500</leader><controlfield tag="001">NLEJ247535370</controlfield><controlfield tag="003">DE-627</controlfield><controlfield tag="005">20220820032810.0</controlfield><controlfield tag="007">cr uuu---uuuuu</controlfield><controlfield tag="008">220814s2012 xx |||||o 00| ||und c</controlfield><datafield tag="024" ind1="7" ind2=" "><subfield code="a">10.1515/revneuro-2012-0050</subfield><subfield code="2">doi</subfield></datafield><datafield tag="028" ind1="5" ind2="2"><subfield code="a">artikel_Grundlieferung.pp</subfield></datafield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(DE-627)NLEJ247535370</subfield></datafield><datafield tag="040" ind1=" " ind2=" "><subfield code="a">DE-627</subfield><subfield code="b">ger</subfield><subfield code="c">DE-627</subfield><subfield code="e">rakwb</subfield></datafield><datafield tag="100" ind1="1" ind2=" "><subfield code="a">Vogel-Ciernia, Annie</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="245" ind1="1" ind2="0"><subfield code="a">Molecular brake pad hypothesis: pulling off the brakes for emotional memory</subfield></datafield><datafield tag="264" ind1=" " ind2="1"><subfield code="b">De Gruyter</subfield><subfield code="c">2012</subfield></datafield><datafield tag="300" ind1=" " ind2=" "><subfield code="a">20</subfield></datafield><datafield tag="336" ind1=" " ind2=" "><subfield code="a">Text</subfield><subfield code="b">txt</subfield><subfield code="2">rdacontent</subfield></datafield><datafield tag="337" ind1=" " ind2=" "><subfield code="a">Computermedien</subfield><subfield code="b">c</subfield><subfield code="2">rdamedia</subfield></datafield><datafield tag="338" ind1=" " ind2=" "><subfield code="a">Online-Ressource</subfield><subfield code="b">cr</subfield><subfield code="2">rdacarrier</subfield></datafield><datafield tag="520" ind1=" " ind2=" "><subfield code="a">Under basal conditions histone deacetylases (HDACs) and their associated co-repressor complexes serve as molecular ‘brake pads’ to prevent the gene expression required for long-term memory formation. 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