Spatial memory, plasticity and nucleus accumbens
Research on the function of the nucleus accumbens, the most ventral component of the striatal complex, has traditionally focused on locomotor activity, reward, motivation and addiction. However, based on the existence of projections to the nucleus accumbens from the allocortical regions involved in...
Ausführliche Beschreibung
Gespeichert in:
| Autor*in: |
Rinaldi, Arianna [verfasserIn] Oliverio, Alberto [verfasserIn] Mele, Andrea [verfasserIn] |
|---|
| Format: |
E-Artikel |
|---|
| Erschienen: |
De Gruyter ; 2012 |
|---|
| Schlagwörter: |
|---|
| Umfang: |
15 |
|---|
| Reproduktion: |
Walter de Gruyter Online Zeitschriften |
|---|---|
| Übergeordnetes Werk: |
Enthalten in: Reviews in the neurosciences - Berlin : de Gruyter, 1987, 23(2012), 5-6 vom: 25. Okt., Seite 527-541 |
| Übergeordnetes Werk: |
volume:23 ; year:2012 ; number:5-6 ; day:25 ; month:10 ; pages:527-541 ; extent:15 |
| Links: |
|---|
| DOI / URN: |
10.1515/revneuro-2012-0070 |
|---|
| Katalog-ID: |
NLEJ247535567 |
|---|
| LEADER | 01000caa a22002652 4500 | ||
|---|---|---|---|
| 001 | NLEJ247535567 | ||
| 003 | DE-627 | ||
| 005 | 20230506005049.0 | ||
| 007 | cr uuu---uuuuu | ||
| 008 | 220814s2012 xx |||||o 00| ||und c | ||
| 024 | 7 | |a 10.1515/revneuro-2012-0070 |2 doi | |
| 028 | 5 | 2 | |a artikel_Grundlieferung.pp |
| 035 | |a (DE-627)NLEJ247535567 | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rakwb | ||
| 100 | 1 | |a Rinaldi, Arianna |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a Spatial memory, plasticity and nucleus accumbens |
| 264 | 1 | |b De Gruyter |c 2012 | |
| 300 | |a 15 | ||
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a Computermedien |b c |2 rdamedia | ||
| 338 | |a Online-Ressource |b cr |2 rdacarrier | ||
| 520 | |a Research on the function of the nucleus accumbens, the most ventral component of the striatal complex, has traditionally focused on locomotor activity, reward, motivation and addiction. However, based on the existence of projections to the nucleus accumbens from the allocortical regions involved in spatial navigation, it has been suggested that this structure plays a role in spatial learning and memory. Lesion and neuropharmacological studies confirm this view, also revealing the complex dynamics of the receptors involved in these processes. Moreover, the effects of post-training intra-nucleus accumbens drug administrations demonstrate the necessity of off-line neural activity within this structure in order to consolidate spatial memory. Blockade of molecular processes implicated in synaptic plasticity, such as cAMP response element-binding protein (CREB)-induced transcription or extracellular matrix remodeling, provides further experimental support to this hypothesis. These observations imply that experience-dependent synaptic plasticity responsible for long-term stabilization of spatial information might occur within the nucleus accumbens, similarly to what has been observed in the hippocampus. This suggests that a comprehensive understanding of spatial memory processing should be viewed in the context of a wider neural circuit. | ||
| 533 | |f Walter de Gruyter Online Zeitschriften | ||
| 650 | 4 | |a CREB | |
| 650 | 4 | |a dopamine | |
| 650 | 4 | |a glutamate plasticity | |
| 650 | 4 | |a long-term depression | |
| 650 | 4 | |a long-term potentiation | |
| 700 | 1 | |a Oliverio, Alberto |e verfasserin |4 aut | |
| 700 | 1 | |a Mele, Andrea |e verfasserin |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |t Reviews in the neurosciences |d Berlin : de Gruyter, 1987 |g 23(2012), 5-6 vom: 25. Okt., Seite 527-541 |w (DE-627)NLEJ248236709 |w (DE-600)2598365-9 |x 2191-0200 |7 nnns |
| 773 | 1 | 8 | |g volume:23 |g year:2012 |g number:5-6 |g day:25 |g month:10 |g pages:527-541 |g extent:15 |
| 856 | 4 | 0 | |u https://doi.org/10.1515/revneuro-2012-0070 |z Deutschlandweit zugänglich |
| 912 | |a GBV_USEFLAG_U | ||
| 912 | |a ZDB-1-DGR | ||
| 912 | |a GBV_NL_ARTICLE | ||
| 951 | |a AR | ||
| 952 | |d 23 |j 2012 |e 5-6 |b 25 |c 10 |h 527-541 |g 15 | ||
| author_variant |
a r ar a o ao a m am |
|---|---|
| matchkey_str |
article:21910200:2012----::ptammrpatctadul |
| hierarchy_sort_str |
2012 |
| publishDate |
2012 |
| allfields |
10.1515/revneuro-2012-0070 doi artikel_Grundlieferung.pp (DE-627)NLEJ247535567 DE-627 ger DE-627 rakwb Rinaldi, Arianna verfasserin aut Spatial memory, plasticity and nucleus accumbens De Gruyter 2012 15 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Research on the function of the nucleus accumbens, the most ventral component of the striatal complex, has traditionally focused on locomotor activity, reward, motivation and addiction. However, based on the existence of projections to the nucleus accumbens from the allocortical regions involved in spatial navigation, it has been suggested that this structure plays a role in spatial learning and memory. Lesion and neuropharmacological studies confirm this view, also revealing the complex dynamics of the receptors involved in these processes. Moreover, the effects of post-training intra-nucleus accumbens drug administrations demonstrate the necessity of off-line neural activity within this structure in order to consolidate spatial memory. Blockade of molecular processes implicated in synaptic plasticity, such as cAMP response element-binding protein (CREB)-induced transcription or extracellular matrix remodeling, provides further experimental support to this hypothesis. These observations imply that experience-dependent synaptic plasticity responsible for long-term stabilization of spatial information might occur within the nucleus accumbens, similarly to what has been observed in the hippocampus. This suggests that a comprehensive understanding of spatial memory processing should be viewed in the context of a wider neural circuit. Walter de Gruyter Online Zeitschriften CREB dopamine glutamate plasticity long-term depression long-term potentiation Oliverio, Alberto verfasserin aut Mele, Andrea verfasserin aut Enthalten in Reviews in the neurosciences Berlin : de Gruyter, 1987 23(2012), 5-6 vom: 25. Okt., Seite 527-541 (DE-627)NLEJ248236709 (DE-600)2598365-9 2191-0200 nnns volume:23 year:2012 number:5-6 day:25 month:10 pages:527-541 extent:15 https://doi.org/10.1515/revneuro-2012-0070 Deutschlandweit zugänglich GBV_USEFLAG_U ZDB-1-DGR GBV_NL_ARTICLE AR 23 2012 5-6 25 10 527-541 15 |
| spelling |
10.1515/revneuro-2012-0070 doi artikel_Grundlieferung.pp (DE-627)NLEJ247535567 DE-627 ger DE-627 rakwb Rinaldi, Arianna verfasserin aut Spatial memory, plasticity and nucleus accumbens De Gruyter 2012 15 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Research on the function of the nucleus accumbens, the most ventral component of the striatal complex, has traditionally focused on locomotor activity, reward, motivation and addiction. However, based on the existence of projections to the nucleus accumbens from the allocortical regions involved in spatial navigation, it has been suggested that this structure plays a role in spatial learning and memory. Lesion and neuropharmacological studies confirm this view, also revealing the complex dynamics of the receptors involved in these processes. Moreover, the effects of post-training intra-nucleus accumbens drug administrations demonstrate the necessity of off-line neural activity within this structure in order to consolidate spatial memory. Blockade of molecular processes implicated in synaptic plasticity, such as cAMP response element-binding protein (CREB)-induced transcription or extracellular matrix remodeling, provides further experimental support to this hypothesis. These observations imply that experience-dependent synaptic plasticity responsible for long-term stabilization of spatial information might occur within the nucleus accumbens, similarly to what has been observed in the hippocampus. This suggests that a comprehensive understanding of spatial memory processing should be viewed in the context of a wider neural circuit. Walter de Gruyter Online Zeitschriften CREB dopamine glutamate plasticity long-term depression long-term potentiation Oliverio, Alberto verfasserin aut Mele, Andrea verfasserin aut Enthalten in Reviews in the neurosciences Berlin : de Gruyter, 1987 23(2012), 5-6 vom: 25. Okt., Seite 527-541 (DE-627)NLEJ248236709 (DE-600)2598365-9 2191-0200 nnns volume:23 year:2012 number:5-6 day:25 month:10 pages:527-541 extent:15 https://doi.org/10.1515/revneuro-2012-0070 Deutschlandweit zugänglich GBV_USEFLAG_U ZDB-1-DGR GBV_NL_ARTICLE AR 23 2012 5-6 25 10 527-541 15 |
| allfields_unstemmed |
10.1515/revneuro-2012-0070 doi artikel_Grundlieferung.pp (DE-627)NLEJ247535567 DE-627 ger DE-627 rakwb Rinaldi, Arianna verfasserin aut Spatial memory, plasticity and nucleus accumbens De Gruyter 2012 15 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Research on the function of the nucleus accumbens, the most ventral component of the striatal complex, has traditionally focused on locomotor activity, reward, motivation and addiction. However, based on the existence of projections to the nucleus accumbens from the allocortical regions involved in spatial navigation, it has been suggested that this structure plays a role in spatial learning and memory. Lesion and neuropharmacological studies confirm this view, also revealing the complex dynamics of the receptors involved in these processes. Moreover, the effects of post-training intra-nucleus accumbens drug administrations demonstrate the necessity of off-line neural activity within this structure in order to consolidate spatial memory. Blockade of molecular processes implicated in synaptic plasticity, such as cAMP response element-binding protein (CREB)-induced transcription or extracellular matrix remodeling, provides further experimental support to this hypothesis. These observations imply that experience-dependent synaptic plasticity responsible for long-term stabilization of spatial information might occur within the nucleus accumbens, similarly to what has been observed in the hippocampus. This suggests that a comprehensive understanding of spatial memory processing should be viewed in the context of a wider neural circuit. Walter de Gruyter Online Zeitschriften CREB dopamine glutamate plasticity long-term depression long-term potentiation Oliverio, Alberto verfasserin aut Mele, Andrea verfasserin aut Enthalten in Reviews in the neurosciences Berlin : de Gruyter, 1987 23(2012), 5-6 vom: 25. Okt., Seite 527-541 (DE-627)NLEJ248236709 (DE-600)2598365-9 2191-0200 nnns volume:23 year:2012 number:5-6 day:25 month:10 pages:527-541 extent:15 https://doi.org/10.1515/revneuro-2012-0070 Deutschlandweit zugänglich GBV_USEFLAG_U ZDB-1-DGR GBV_NL_ARTICLE AR 23 2012 5-6 25 10 527-541 15 |
| allfieldsGer |
10.1515/revneuro-2012-0070 doi artikel_Grundlieferung.pp (DE-627)NLEJ247535567 DE-627 ger DE-627 rakwb Rinaldi, Arianna verfasserin aut Spatial memory, plasticity and nucleus accumbens De Gruyter 2012 15 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Research on the function of the nucleus accumbens, the most ventral component of the striatal complex, has traditionally focused on locomotor activity, reward, motivation and addiction. However, based on the existence of projections to the nucleus accumbens from the allocortical regions involved in spatial navigation, it has been suggested that this structure plays a role in spatial learning and memory. Lesion and neuropharmacological studies confirm this view, also revealing the complex dynamics of the receptors involved in these processes. Moreover, the effects of post-training intra-nucleus accumbens drug administrations demonstrate the necessity of off-line neural activity within this structure in order to consolidate spatial memory. Blockade of molecular processes implicated in synaptic plasticity, such as cAMP response element-binding protein (CREB)-induced transcription or extracellular matrix remodeling, provides further experimental support to this hypothesis. These observations imply that experience-dependent synaptic plasticity responsible for long-term stabilization of spatial information might occur within the nucleus accumbens, similarly to what has been observed in the hippocampus. This suggests that a comprehensive understanding of spatial memory processing should be viewed in the context of a wider neural circuit. Walter de Gruyter Online Zeitschriften CREB dopamine glutamate plasticity long-term depression long-term potentiation Oliverio, Alberto verfasserin aut Mele, Andrea verfasserin aut Enthalten in Reviews in the neurosciences Berlin : de Gruyter, 1987 23(2012), 5-6 vom: 25. Okt., Seite 527-541 (DE-627)NLEJ248236709 (DE-600)2598365-9 2191-0200 nnns volume:23 year:2012 number:5-6 day:25 month:10 pages:527-541 extent:15 https://doi.org/10.1515/revneuro-2012-0070 Deutschlandweit zugänglich GBV_USEFLAG_U ZDB-1-DGR GBV_NL_ARTICLE AR 23 2012 5-6 25 10 527-541 15 |
| allfieldsSound |
10.1515/revneuro-2012-0070 doi artikel_Grundlieferung.pp (DE-627)NLEJ247535567 DE-627 ger DE-627 rakwb Rinaldi, Arianna verfasserin aut Spatial memory, plasticity and nucleus accumbens De Gruyter 2012 15 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Research on the function of the nucleus accumbens, the most ventral component of the striatal complex, has traditionally focused on locomotor activity, reward, motivation and addiction. However, based on the existence of projections to the nucleus accumbens from the allocortical regions involved in spatial navigation, it has been suggested that this structure plays a role in spatial learning and memory. Lesion and neuropharmacological studies confirm this view, also revealing the complex dynamics of the receptors involved in these processes. Moreover, the effects of post-training intra-nucleus accumbens drug administrations demonstrate the necessity of off-line neural activity within this structure in order to consolidate spatial memory. Blockade of molecular processes implicated in synaptic plasticity, such as cAMP response element-binding protein (CREB)-induced transcription or extracellular matrix remodeling, provides further experimental support to this hypothesis. These observations imply that experience-dependent synaptic plasticity responsible for long-term stabilization of spatial information might occur within the nucleus accumbens, similarly to what has been observed in the hippocampus. This suggests that a comprehensive understanding of spatial memory processing should be viewed in the context of a wider neural circuit. Walter de Gruyter Online Zeitschriften CREB dopamine glutamate plasticity long-term depression long-term potentiation Oliverio, Alberto verfasserin aut Mele, Andrea verfasserin aut Enthalten in Reviews in the neurosciences Berlin : de Gruyter, 1987 23(2012), 5-6 vom: 25. Okt., Seite 527-541 (DE-627)NLEJ248236709 (DE-600)2598365-9 2191-0200 nnns volume:23 year:2012 number:5-6 day:25 month:10 pages:527-541 extent:15 https://doi.org/10.1515/revneuro-2012-0070 Deutschlandweit zugänglich GBV_USEFLAG_U ZDB-1-DGR GBV_NL_ARTICLE AR 23 2012 5-6 25 10 527-541 15 |
| source |
Enthalten in Reviews in the neurosciences 23(2012), 5-6 vom: 25. Okt., Seite 527-541 volume:23 year:2012 number:5-6 day:25 month:10 pages:527-541 extent:15 |
| sourceStr |
Enthalten in Reviews in the neurosciences 23(2012), 5-6 vom: 25. Okt., Seite 527-541 volume:23 year:2012 number:5-6 day:25 month:10 pages:527-541 extent:15 |
| format_phy_str_mv |
Article |
| institution |
findex.gbv.de |
| topic_facet |
CREB dopamine glutamate plasticity long-term depression long-term potentiation |
| isfreeaccess_bool |
false |
| container_title |
Reviews in the neurosciences |
| authorswithroles_txt_mv |
Rinaldi, Arianna @@aut@@ Oliverio, Alberto @@aut@@ Mele, Andrea @@aut@@ |
| publishDateDaySort_date |
2012-10-25T00:00:00Z |
| hierarchy_top_id |
NLEJ248236709 |
| id |
NLEJ247535567 |
| fullrecord |
<?xml version="1.0" encoding="UTF-8"?><collection xmlns="http://www.loc.gov/MARC21/slim"><record><leader>01000caa a22002652 4500</leader><controlfield tag="001">NLEJ247535567</controlfield><controlfield tag="003">DE-627</controlfield><controlfield tag="005">20230506005049.0</controlfield><controlfield tag="007">cr uuu---uuuuu</controlfield><controlfield tag="008">220814s2012 xx |||||o 00| ||und c</controlfield><datafield tag="024" ind1="7" ind2=" "><subfield code="a">10.1515/revneuro-2012-0070</subfield><subfield code="2">doi</subfield></datafield><datafield tag="028" ind1="5" ind2="2"><subfield code="a">artikel_Grundlieferung.pp</subfield></datafield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(DE-627)NLEJ247535567</subfield></datafield><datafield tag="040" ind1=" " ind2=" "><subfield code="a">DE-627</subfield><subfield code="b">ger</subfield><subfield code="c">DE-627</subfield><subfield code="e">rakwb</subfield></datafield><datafield tag="100" ind1="1" ind2=" "><subfield code="a">Rinaldi, Arianna</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="245" ind1="1" ind2="0"><subfield code="a">Spatial memory, plasticity and nucleus accumbens</subfield></datafield><datafield tag="264" ind1=" " ind2="1"><subfield code="b">De Gruyter</subfield><subfield code="c">2012</subfield></datafield><datafield tag="300" ind1=" " ind2=" "><subfield code="a">15</subfield></datafield><datafield tag="336" ind1=" " ind2=" "><subfield code="a">Text</subfield><subfield code="b">txt</subfield><subfield code="2">rdacontent</subfield></datafield><datafield tag="337" ind1=" " ind2=" "><subfield code="a">Computermedien</subfield><subfield code="b">c</subfield><subfield code="2">rdamedia</subfield></datafield><datafield tag="338" ind1=" " ind2=" "><subfield code="a">Online-Ressource</subfield><subfield code="b">cr</subfield><subfield code="2">rdacarrier</subfield></datafield><datafield tag="520" ind1=" " ind2=" "><subfield code="a">Research on the function of the nucleus accumbens, the most ventral component of the striatal complex, has traditionally focused on locomotor activity, reward, motivation and addiction. However, based on the existence of projections to the nucleus accumbens from the allocortical regions involved in spatial navigation, it has been suggested that this structure plays a role in spatial learning and memory. Lesion and neuropharmacological studies confirm this view, also revealing the complex dynamics of the receptors involved in these processes. Moreover, the effects of post-training intra-nucleus accumbens drug administrations demonstrate the necessity of off-line neural activity within this structure in order to consolidate spatial memory. Blockade of molecular processes implicated in synaptic plasticity, such as cAMP response element-binding protein (CREB)-induced transcription or extracellular matrix remodeling, provides further experimental support to this hypothesis. These observations imply that experience-dependent synaptic plasticity responsible for long-term stabilization of spatial information might occur within the nucleus accumbens, similarly to what has been observed in the hippocampus. This suggests that a comprehensive understanding of spatial memory processing should be viewed in the context of a wider neural circuit.</subfield></datafield><datafield tag="533" ind1=" " ind2=" "><subfield code="f">Walter de Gruyter Online Zeitschriften</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">CREB</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">dopamine</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">glutamate plasticity</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">long-term depression</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">long-term potentiation</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Oliverio, Alberto</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Mele, Andrea</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="773" ind1="0" ind2="8"><subfield code="i">Enthalten in</subfield><subfield code="t">Reviews in the neurosciences</subfield><subfield code="d">Berlin : de Gruyter, 1987</subfield><subfield code="g">23(2012), 5-6 vom: 25. Okt., Seite 527-541</subfield><subfield code="w">(DE-627)NLEJ248236709</subfield><subfield code="w">(DE-600)2598365-9</subfield><subfield code="x">2191-0200</subfield><subfield code="7">nnns</subfield></datafield><datafield tag="773" ind1="1" ind2="8"><subfield code="g">volume:23</subfield><subfield code="g">year:2012</subfield><subfield code="g">number:5-6</subfield><subfield code="g">day:25</subfield><subfield code="g">month:10</subfield><subfield code="g">pages:527-541</subfield><subfield code="g">extent:15</subfield></datafield><datafield tag="856" ind1="4" ind2="0"><subfield code="u">https://doi.org/10.1515/revneuro-2012-0070</subfield><subfield code="z">Deutschlandweit zugänglich</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_USEFLAG_U</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">ZDB-1-DGR</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_NL_ARTICLE</subfield></datafield><datafield tag="951" ind1=" " ind2=" "><subfield code="a">AR</subfield></datafield><datafield tag="952" ind1=" " ind2=" "><subfield code="d">23</subfield><subfield code="j">2012</subfield><subfield code="e">5-6</subfield><subfield code="b">25</subfield><subfield code="c">10</subfield><subfield code="h">527-541</subfield><subfield code="g">15</subfield></datafield></record></collection>
|
| series2 |
Walter de Gruyter Online Zeitschriften |
| author |
Rinaldi, Arianna |
| spellingShingle |
Rinaldi, Arianna misc CREB misc dopamine misc glutamate plasticity misc long-term depression misc long-term potentiation Spatial memory, plasticity and nucleus accumbens |
| authorStr |
Rinaldi, Arianna |
| ppnlink_with_tag_str_mv |
@@773@@(DE-627)NLEJ248236709 |
| format |
electronic Article |
| delete_txt_mv |
keep |
| author_role |
aut aut aut |
| collection |
NL |
| remote_str |
true |
| illustrated |
Not Illustrated |
| issn |
2191-0200 |
| topic_title |
Spatial memory, plasticity and nucleus accumbens CREB dopamine glutamate plasticity long-term depression long-term potentiation |
| publisher |
De Gruyter |
| publisherStr |
De Gruyter |
| topic |
misc CREB misc dopamine misc glutamate plasticity misc long-term depression misc long-term potentiation |
| topic_unstemmed |
misc CREB misc dopamine misc glutamate plasticity misc long-term depression misc long-term potentiation |
| topic_browse |
misc CREB misc dopamine misc glutamate plasticity misc long-term depression misc long-term potentiation |
| format_facet |
Elektronische Aufsätze Aufsätze Elektronische Ressource |
| format_main_str_mv |
Text Zeitschrift/Artikel |
| carriertype_str_mv |
cr |
| hierarchy_parent_title |
Reviews in the neurosciences |
| hierarchy_parent_id |
NLEJ248236709 |
| hierarchy_top_title |
Reviews in the neurosciences |
| isfreeaccess_txt |
false |
| familylinks_str_mv |
(DE-627)NLEJ248236709 (DE-600)2598365-9 |
| title |
Spatial memory, plasticity and nucleus accumbens |
| ctrlnum |
(DE-627)NLEJ247535567 |
| title_full |
Spatial memory, plasticity and nucleus accumbens |
| author_sort |
Rinaldi, Arianna |
| journal |
Reviews in the neurosciences |
| journalStr |
Reviews in the neurosciences |
| isOA_bool |
false |
| recordtype |
marc |
| publishDateSort |
2012 |
| contenttype_str_mv |
txt |
| container_start_page |
527 |
| author_browse |
Rinaldi, Arianna Oliverio, Alberto Mele, Andrea |
| container_volume |
23 |
| physical |
15 |
| format_se |
Elektronische Aufsätze |
| author-letter |
Rinaldi, Arianna |
| doi_str_mv |
10.1515/revneuro-2012-0070 |
| author2-role |
verfasserin |
| title_sort |
spatial memory, plasticity and nucleus accumbens |
| title_auth |
Spatial memory, plasticity and nucleus accumbens |
| abstract |
Research on the function of the nucleus accumbens, the most ventral component of the striatal complex, has traditionally focused on locomotor activity, reward, motivation and addiction. However, based on the existence of projections to the nucleus accumbens from the allocortical regions involved in spatial navigation, it has been suggested that this structure plays a role in spatial learning and memory. Lesion and neuropharmacological studies confirm this view, also revealing the complex dynamics of the receptors involved in these processes. Moreover, the effects of post-training intra-nucleus accumbens drug administrations demonstrate the necessity of off-line neural activity within this structure in order to consolidate spatial memory. Blockade of molecular processes implicated in synaptic plasticity, such as cAMP response element-binding protein (CREB)-induced transcription or extracellular matrix remodeling, provides further experimental support to this hypothesis. These observations imply that experience-dependent synaptic plasticity responsible for long-term stabilization of spatial information might occur within the nucleus accumbens, similarly to what has been observed in the hippocampus. This suggests that a comprehensive understanding of spatial memory processing should be viewed in the context of a wider neural circuit. |
| abstractGer |
Research on the function of the nucleus accumbens, the most ventral component of the striatal complex, has traditionally focused on locomotor activity, reward, motivation and addiction. However, based on the existence of projections to the nucleus accumbens from the allocortical regions involved in spatial navigation, it has been suggested that this structure plays a role in spatial learning and memory. Lesion and neuropharmacological studies confirm this view, also revealing the complex dynamics of the receptors involved in these processes. Moreover, the effects of post-training intra-nucleus accumbens drug administrations demonstrate the necessity of off-line neural activity within this structure in order to consolidate spatial memory. Blockade of molecular processes implicated in synaptic plasticity, such as cAMP response element-binding protein (CREB)-induced transcription or extracellular matrix remodeling, provides further experimental support to this hypothesis. These observations imply that experience-dependent synaptic plasticity responsible for long-term stabilization of spatial information might occur within the nucleus accumbens, similarly to what has been observed in the hippocampus. This suggests that a comprehensive understanding of spatial memory processing should be viewed in the context of a wider neural circuit. |
| abstract_unstemmed |
Research on the function of the nucleus accumbens, the most ventral component of the striatal complex, has traditionally focused on locomotor activity, reward, motivation and addiction. However, based on the existence of projections to the nucleus accumbens from the allocortical regions involved in spatial navigation, it has been suggested that this structure plays a role in spatial learning and memory. Lesion and neuropharmacological studies confirm this view, also revealing the complex dynamics of the receptors involved in these processes. Moreover, the effects of post-training intra-nucleus accumbens drug administrations demonstrate the necessity of off-line neural activity within this structure in order to consolidate spatial memory. Blockade of molecular processes implicated in synaptic plasticity, such as cAMP response element-binding protein (CREB)-induced transcription or extracellular matrix remodeling, provides further experimental support to this hypothesis. These observations imply that experience-dependent synaptic plasticity responsible for long-term stabilization of spatial information might occur within the nucleus accumbens, similarly to what has been observed in the hippocampus. This suggests that a comprehensive understanding of spatial memory processing should be viewed in the context of a wider neural circuit. |
| collection_details |
GBV_USEFLAG_U ZDB-1-DGR GBV_NL_ARTICLE |
| container_issue |
5-6 |
| title_short |
Spatial memory, plasticity and nucleus accumbens |
| url |
https://doi.org/10.1515/revneuro-2012-0070 |
| remote_bool |
true |
| author2 |
Oliverio, Alberto Mele, Andrea |
| author2Str |
Oliverio, Alberto Mele, Andrea |
| ppnlink |
NLEJ248236709 |
| mediatype_str_mv |
c |
| isOA_txt |
false |
| hochschulschrift_bool |
false |
| doi_str |
10.1515/revneuro-2012-0070 |
| up_date |
2024-07-06T10:44:02.571Z |
| _version_ |
1803826120697577472 |
| fullrecord_marcxml |
<?xml version="1.0" encoding="UTF-8"?><collection xmlns="http://www.loc.gov/MARC21/slim"><record><leader>01000caa a22002652 4500</leader><controlfield tag="001">NLEJ247535567</controlfield><controlfield tag="003">DE-627</controlfield><controlfield tag="005">20230506005049.0</controlfield><controlfield tag="007">cr uuu---uuuuu</controlfield><controlfield tag="008">220814s2012 xx |||||o 00| ||und c</controlfield><datafield tag="024" ind1="7" ind2=" "><subfield code="a">10.1515/revneuro-2012-0070</subfield><subfield code="2">doi</subfield></datafield><datafield tag="028" ind1="5" ind2="2"><subfield code="a">artikel_Grundlieferung.pp</subfield></datafield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(DE-627)NLEJ247535567</subfield></datafield><datafield tag="040" ind1=" " ind2=" "><subfield code="a">DE-627</subfield><subfield code="b">ger</subfield><subfield code="c">DE-627</subfield><subfield code="e">rakwb</subfield></datafield><datafield tag="100" ind1="1" ind2=" "><subfield code="a">Rinaldi, Arianna</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="245" ind1="1" ind2="0"><subfield code="a">Spatial memory, plasticity and nucleus accumbens</subfield></datafield><datafield tag="264" ind1=" " ind2="1"><subfield code="b">De Gruyter</subfield><subfield code="c">2012</subfield></datafield><datafield tag="300" ind1=" " ind2=" "><subfield code="a">15</subfield></datafield><datafield tag="336" ind1=" " ind2=" "><subfield code="a">Text</subfield><subfield code="b">txt</subfield><subfield code="2">rdacontent</subfield></datafield><datafield tag="337" ind1=" " ind2=" "><subfield code="a">Computermedien</subfield><subfield code="b">c</subfield><subfield code="2">rdamedia</subfield></datafield><datafield tag="338" ind1=" " ind2=" "><subfield code="a">Online-Ressource</subfield><subfield code="b">cr</subfield><subfield code="2">rdacarrier</subfield></datafield><datafield tag="520" ind1=" " ind2=" "><subfield code="a">Research on the function of the nucleus accumbens, the most ventral component of the striatal complex, has traditionally focused on locomotor activity, reward, motivation and addiction. However, based on the existence of projections to the nucleus accumbens from the allocortical regions involved in spatial navigation, it has been suggested that this structure plays a role in spatial learning and memory. Lesion and neuropharmacological studies confirm this view, also revealing the complex dynamics of the receptors involved in these processes. Moreover, the effects of post-training intra-nucleus accumbens drug administrations demonstrate the necessity of off-line neural activity within this structure in order to consolidate spatial memory. Blockade of molecular processes implicated in synaptic plasticity, such as cAMP response element-binding protein (CREB)-induced transcription or extracellular matrix remodeling, provides further experimental support to this hypothesis. These observations imply that experience-dependent synaptic plasticity responsible for long-term stabilization of spatial information might occur within the nucleus accumbens, similarly to what has been observed in the hippocampus. This suggests that a comprehensive understanding of spatial memory processing should be viewed in the context of a wider neural circuit.</subfield></datafield><datafield tag="533" ind1=" " ind2=" "><subfield code="f">Walter de Gruyter Online Zeitschriften</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">CREB</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">dopamine</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">glutamate plasticity</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">long-term depression</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">long-term potentiation</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Oliverio, Alberto</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Mele, Andrea</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="773" ind1="0" ind2="8"><subfield code="i">Enthalten in</subfield><subfield code="t">Reviews in the neurosciences</subfield><subfield code="d">Berlin : de Gruyter, 1987</subfield><subfield code="g">23(2012), 5-6 vom: 25. Okt., Seite 527-541</subfield><subfield code="w">(DE-627)NLEJ248236709</subfield><subfield code="w">(DE-600)2598365-9</subfield><subfield code="x">2191-0200</subfield><subfield code="7">nnns</subfield></datafield><datafield tag="773" ind1="1" ind2="8"><subfield code="g">volume:23</subfield><subfield code="g">year:2012</subfield><subfield code="g">number:5-6</subfield><subfield code="g">day:25</subfield><subfield code="g">month:10</subfield><subfield code="g">pages:527-541</subfield><subfield code="g">extent:15</subfield></datafield><datafield tag="856" ind1="4" ind2="0"><subfield code="u">https://doi.org/10.1515/revneuro-2012-0070</subfield><subfield code="z">Deutschlandweit zugänglich</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_USEFLAG_U</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">ZDB-1-DGR</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_NL_ARTICLE</subfield></datafield><datafield tag="951" ind1=" " ind2=" "><subfield code="a">AR</subfield></datafield><datafield tag="952" ind1=" " ind2=" "><subfield code="d">23</subfield><subfield code="j">2012</subfield><subfield code="e">5-6</subfield><subfield code="b">25</subfield><subfield code="c">10</subfield><subfield code="h">527-541</subfield><subfield code="g">15</subfield></datafield></record></collection>
|
| score |
7.3975964 |