Spatial memory, plasticity and nucleus accumbens
Research on the function of the nucleus accumbens, the most ventral component of the striatal complex, has traditionally focused on locomotor activity, reward, motivation and addiction. However, based on the existence of projections to the nucleus accumbens from the allocortical regions involved in...
Ausführliche Beschreibung
Autor*in: |
Rinaldi, Arianna [verfasserIn] Oliverio, Alberto [verfasserIn] Mele, Andrea [verfasserIn] |
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E-Artikel |
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Erschienen: |
De Gruyter ; 2012 |
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Umfang: |
15 |
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Reproduktion: |
Walter de Gruyter Online Zeitschriften |
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Übergeordnetes Werk: |
Enthalten in: Reviews in the neurosciences - Berlin : de Gruyter, 1987, 23(2012), 5-6 vom: 25. Okt., Seite 527-541 |
Übergeordnetes Werk: |
volume:23 ; year:2012 ; number:5-6 ; day:25 ; month:10 ; pages:527-541 ; extent:15 |
Links: |
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DOI / URN: |
10.1515/revneuro-2012-0070 |
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NLEJ247535567 |
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10.1515/revneuro-2012-0070 doi artikel_Grundlieferung.pp (DE-627)NLEJ247535567 DE-627 ger DE-627 rakwb Rinaldi, Arianna verfasserin aut Spatial memory, plasticity and nucleus accumbens De Gruyter 2012 15 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Research on the function of the nucleus accumbens, the most ventral component of the striatal complex, has traditionally focused on locomotor activity, reward, motivation and addiction. However, based on the existence of projections to the nucleus accumbens from the allocortical regions involved in spatial navigation, it has been suggested that this structure plays a role in spatial learning and memory. Lesion and neuropharmacological studies confirm this view, also revealing the complex dynamics of the receptors involved in these processes. Moreover, the effects of post-training intra-nucleus accumbens drug administrations demonstrate the necessity of off-line neural activity within this structure in order to consolidate spatial memory. Blockade of molecular processes implicated in synaptic plasticity, such as cAMP response element-binding protein (CREB)-induced transcription or extracellular matrix remodeling, provides further experimental support to this hypothesis. These observations imply that experience-dependent synaptic plasticity responsible for long-term stabilization of spatial information might occur within the nucleus accumbens, similarly to what has been observed in the hippocampus. This suggests that a comprehensive understanding of spatial memory processing should be viewed in the context of a wider neural circuit. Walter de Gruyter Online Zeitschriften CREB dopamine glutamate plasticity long-term depression long-term potentiation Oliverio, Alberto verfasserin aut Mele, Andrea verfasserin aut Enthalten in Reviews in the neurosciences Berlin : de Gruyter, 1987 23(2012), 5-6 vom: 25. Okt., Seite 527-541 (DE-627)NLEJ248236709 (DE-600)2598365-9 2191-0200 nnns volume:23 year:2012 number:5-6 day:25 month:10 pages:527-541 extent:15 https://doi.org/10.1515/revneuro-2012-0070 Deutschlandweit zugänglich GBV_USEFLAG_U ZDB-1-DGR GBV_NL_ARTICLE AR 23 2012 5-6 25 10 527-541 15 |
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10.1515/revneuro-2012-0070 doi artikel_Grundlieferung.pp (DE-627)NLEJ247535567 DE-627 ger DE-627 rakwb Rinaldi, Arianna verfasserin aut Spatial memory, plasticity and nucleus accumbens De Gruyter 2012 15 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Research on the function of the nucleus accumbens, the most ventral component of the striatal complex, has traditionally focused on locomotor activity, reward, motivation and addiction. However, based on the existence of projections to the nucleus accumbens from the allocortical regions involved in spatial navigation, it has been suggested that this structure plays a role in spatial learning and memory. Lesion and neuropharmacological studies confirm this view, also revealing the complex dynamics of the receptors involved in these processes. Moreover, the effects of post-training intra-nucleus accumbens drug administrations demonstrate the necessity of off-line neural activity within this structure in order to consolidate spatial memory. Blockade of molecular processes implicated in synaptic plasticity, such as cAMP response element-binding protein (CREB)-induced transcription or extracellular matrix remodeling, provides further experimental support to this hypothesis. These observations imply that experience-dependent synaptic plasticity responsible for long-term stabilization of spatial information might occur within the nucleus accumbens, similarly to what has been observed in the hippocampus. This suggests that a comprehensive understanding of spatial memory processing should be viewed in the context of a wider neural circuit. Walter de Gruyter Online Zeitschriften CREB dopamine glutamate plasticity long-term depression long-term potentiation Oliverio, Alberto verfasserin aut Mele, Andrea verfasserin aut Enthalten in Reviews in the neurosciences Berlin : de Gruyter, 1987 23(2012), 5-6 vom: 25. Okt., Seite 527-541 (DE-627)NLEJ248236709 (DE-600)2598365-9 2191-0200 nnns volume:23 year:2012 number:5-6 day:25 month:10 pages:527-541 extent:15 https://doi.org/10.1515/revneuro-2012-0070 Deutschlandweit zugänglich GBV_USEFLAG_U ZDB-1-DGR GBV_NL_ARTICLE AR 23 2012 5-6 25 10 527-541 15 |
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10.1515/revneuro-2012-0070 doi artikel_Grundlieferung.pp (DE-627)NLEJ247535567 DE-627 ger DE-627 rakwb Rinaldi, Arianna verfasserin aut Spatial memory, plasticity and nucleus accumbens De Gruyter 2012 15 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Research on the function of the nucleus accumbens, the most ventral component of the striatal complex, has traditionally focused on locomotor activity, reward, motivation and addiction. However, based on the existence of projections to the nucleus accumbens from the allocortical regions involved in spatial navigation, it has been suggested that this structure plays a role in spatial learning and memory. Lesion and neuropharmacological studies confirm this view, also revealing the complex dynamics of the receptors involved in these processes. Moreover, the effects of post-training intra-nucleus accumbens drug administrations demonstrate the necessity of off-line neural activity within this structure in order to consolidate spatial memory. Blockade of molecular processes implicated in synaptic plasticity, such as cAMP response element-binding protein (CREB)-induced transcription or extracellular matrix remodeling, provides further experimental support to this hypothesis. These observations imply that experience-dependent synaptic plasticity responsible for long-term stabilization of spatial information might occur within the nucleus accumbens, similarly to what has been observed in the hippocampus. This suggests that a comprehensive understanding of spatial memory processing should be viewed in the context of a wider neural circuit. Walter de Gruyter Online Zeitschriften CREB dopamine glutamate plasticity long-term depression long-term potentiation Oliverio, Alberto verfasserin aut Mele, Andrea verfasserin aut Enthalten in Reviews in the neurosciences Berlin : de Gruyter, 1987 23(2012), 5-6 vom: 25. Okt., Seite 527-541 (DE-627)NLEJ248236709 (DE-600)2598365-9 2191-0200 nnns volume:23 year:2012 number:5-6 day:25 month:10 pages:527-541 extent:15 https://doi.org/10.1515/revneuro-2012-0070 Deutschlandweit zugänglich GBV_USEFLAG_U ZDB-1-DGR GBV_NL_ARTICLE AR 23 2012 5-6 25 10 527-541 15 |
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10.1515/revneuro-2012-0070 doi artikel_Grundlieferung.pp (DE-627)NLEJ247535567 DE-627 ger DE-627 rakwb Rinaldi, Arianna verfasserin aut Spatial memory, plasticity and nucleus accumbens De Gruyter 2012 15 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Research on the function of the nucleus accumbens, the most ventral component of the striatal complex, has traditionally focused on locomotor activity, reward, motivation and addiction. However, based on the existence of projections to the nucleus accumbens from the allocortical regions involved in spatial navigation, it has been suggested that this structure plays a role in spatial learning and memory. Lesion and neuropharmacological studies confirm this view, also revealing the complex dynamics of the receptors involved in these processes. Moreover, the effects of post-training intra-nucleus accumbens drug administrations demonstrate the necessity of off-line neural activity within this structure in order to consolidate spatial memory. Blockade of molecular processes implicated in synaptic plasticity, such as cAMP response element-binding protein (CREB)-induced transcription or extracellular matrix remodeling, provides further experimental support to this hypothesis. These observations imply that experience-dependent synaptic plasticity responsible for long-term stabilization of spatial information might occur within the nucleus accumbens, similarly to what has been observed in the hippocampus. This suggests that a comprehensive understanding of spatial memory processing should be viewed in the context of a wider neural circuit. Walter de Gruyter Online Zeitschriften CREB dopamine glutamate plasticity long-term depression long-term potentiation Oliverio, Alberto verfasserin aut Mele, Andrea verfasserin aut Enthalten in Reviews in the neurosciences Berlin : de Gruyter, 1987 23(2012), 5-6 vom: 25. Okt., Seite 527-541 (DE-627)NLEJ248236709 (DE-600)2598365-9 2191-0200 nnns volume:23 year:2012 number:5-6 day:25 month:10 pages:527-541 extent:15 https://doi.org/10.1515/revneuro-2012-0070 Deutschlandweit zugänglich GBV_USEFLAG_U ZDB-1-DGR GBV_NL_ARTICLE AR 23 2012 5-6 25 10 527-541 15 |
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Research on the function of the nucleus accumbens, the most ventral component of the striatal complex, has traditionally focused on locomotor activity, reward, motivation and addiction. However, based on the existence of projections to the nucleus accumbens from the allocortical regions involved in spatial navigation, it has been suggested that this structure plays a role in spatial learning and memory. Lesion and neuropharmacological studies confirm this view, also revealing the complex dynamics of the receptors involved in these processes. Moreover, the effects of post-training intra-nucleus accumbens drug administrations demonstrate the necessity of off-line neural activity within this structure in order to consolidate spatial memory. Blockade of molecular processes implicated in synaptic plasticity, such as cAMP response element-binding protein (CREB)-induced transcription or extracellular matrix remodeling, provides further experimental support to this hypothesis. These observations imply that experience-dependent synaptic plasticity responsible for long-term stabilization of spatial information might occur within the nucleus accumbens, similarly to what has been observed in the hippocampus. This suggests that a comprehensive understanding of spatial memory processing should be viewed in the context of a wider neural circuit. |
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Research on the function of the nucleus accumbens, the most ventral component of the striatal complex, has traditionally focused on locomotor activity, reward, motivation and addiction. However, based on the existence of projections to the nucleus accumbens from the allocortical regions involved in spatial navigation, it has been suggested that this structure plays a role in spatial learning and memory. Lesion and neuropharmacological studies confirm this view, also revealing the complex dynamics of the receptors involved in these processes. Moreover, the effects of post-training intra-nucleus accumbens drug administrations demonstrate the necessity of off-line neural activity within this structure in order to consolidate spatial memory. Blockade of molecular processes implicated in synaptic plasticity, such as cAMP response element-binding protein (CREB)-induced transcription or extracellular matrix remodeling, provides further experimental support to this hypothesis. These observations imply that experience-dependent synaptic plasticity responsible for long-term stabilization of spatial information might occur within the nucleus accumbens, similarly to what has been observed in the hippocampus. This suggests that a comprehensive understanding of spatial memory processing should be viewed in the context of a wider neural circuit. |
abstract_unstemmed |
Research on the function of the nucleus accumbens, the most ventral component of the striatal complex, has traditionally focused on locomotor activity, reward, motivation and addiction. However, based on the existence of projections to the nucleus accumbens from the allocortical regions involved in spatial navigation, it has been suggested that this structure plays a role in spatial learning and memory. Lesion and neuropharmacological studies confirm this view, also revealing the complex dynamics of the receptors involved in these processes. Moreover, the effects of post-training intra-nucleus accumbens drug administrations demonstrate the necessity of off-line neural activity within this structure in order to consolidate spatial memory. Blockade of molecular processes implicated in synaptic plasticity, such as cAMP response element-binding protein (CREB)-induced transcription or extracellular matrix remodeling, provides further experimental support to this hypothesis. These observations imply that experience-dependent synaptic plasticity responsible for long-term stabilization of spatial information might occur within the nucleus accumbens, similarly to what has been observed in the hippocampus. This suggests that a comprehensive understanding of spatial memory processing should be viewed in the context of a wider neural circuit. |
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<?xml version="1.0" encoding="UTF-8"?><collection xmlns="http://www.loc.gov/MARC21/slim"><record><leader>01000caa a22002652 4500</leader><controlfield tag="001">NLEJ247535567</controlfield><controlfield tag="003">DE-627</controlfield><controlfield tag="005">20230506005049.0</controlfield><controlfield tag="007">cr uuu---uuuuu</controlfield><controlfield tag="008">220814s2012 xx |||||o 00| ||und c</controlfield><datafield tag="024" ind1="7" ind2=" "><subfield code="a">10.1515/revneuro-2012-0070</subfield><subfield code="2">doi</subfield></datafield><datafield tag="028" ind1="5" ind2="2"><subfield code="a">artikel_Grundlieferung.pp</subfield></datafield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(DE-627)NLEJ247535567</subfield></datafield><datafield tag="040" ind1=" " ind2=" "><subfield code="a">DE-627</subfield><subfield code="b">ger</subfield><subfield code="c">DE-627</subfield><subfield code="e">rakwb</subfield></datafield><datafield tag="100" ind1="1" ind2=" "><subfield code="a">Rinaldi, Arianna</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="245" ind1="1" ind2="0"><subfield code="a">Spatial memory, plasticity and nucleus accumbens</subfield></datafield><datafield tag="264" ind1=" " ind2="1"><subfield code="b">De Gruyter</subfield><subfield code="c">2012</subfield></datafield><datafield tag="300" ind1=" " ind2=" "><subfield code="a">15</subfield></datafield><datafield tag="336" ind1=" " ind2=" "><subfield code="a">Text</subfield><subfield code="b">txt</subfield><subfield code="2">rdacontent</subfield></datafield><datafield tag="337" ind1=" " ind2=" "><subfield code="a">Computermedien</subfield><subfield code="b">c</subfield><subfield code="2">rdamedia</subfield></datafield><datafield tag="338" ind1=" " ind2=" "><subfield code="a">Online-Ressource</subfield><subfield code="b">cr</subfield><subfield code="2">rdacarrier</subfield></datafield><datafield tag="520" ind1=" " ind2=" "><subfield code="a">Research on the function of the nucleus accumbens, the most ventral component of the striatal complex, has traditionally focused on locomotor activity, reward, motivation and addiction. However, based on the existence of projections to the nucleus accumbens from the allocortical regions involved in spatial navigation, it has been suggested that this structure plays a role in spatial learning and memory. Lesion and neuropharmacological studies confirm this view, also revealing the complex dynamics of the receptors involved in these processes. Moreover, the effects of post-training intra-nucleus accumbens drug administrations demonstrate the necessity of off-line neural activity within this structure in order to consolidate spatial memory. Blockade of molecular processes implicated in synaptic plasticity, such as cAMP response element-binding protein (CREB)-induced transcription or extracellular matrix remodeling, provides further experimental support to this hypothesis. These observations imply that experience-dependent synaptic plasticity responsible for long-term stabilization of spatial information might occur within the nucleus accumbens, similarly to what has been observed in the hippocampus. 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