Cathelicidins Revisited : Molecular Evolution, Structure and Functional Implications
Cathelicidins constitute important antimicrobial peptides of innate immunity. In order to elucidate the evolutionary history of cathelicidins, the author performed comprehensive phylogenetic analyses of cathelicidin homologs in all available genomes including those completed recently. The organizati...
Ausführliche Beschreibung
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| Autor*in: |
Pavlopoulou, Athanasia [verfasserIn] |
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| Sprache: |
Englisch |
| Erschienen: |
2013 |
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| Umfang: |
1 Online-Ressource |
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| Übergeordnetes Werk: |
Enthalten in: International journal of systems biology and biomedical technologies - Hershey, Pa : IGI Global, 2012, 2(2013), 2, Seite 8-32 |
|---|---|
| Übergeordnetes Werk: |
volume:2 ; year:2013 ; number:2 ; pages:8-32 |
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| DOI / URN: |
10.4018/ijsbbt.2013040102 |
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| 520 | |a Cathelicidins constitute important antimicrobial peptides of innate immunity. In order to elucidate the evolutionary history of cathelicidins, the author performed comprehensive phylogenetic analyses of cathelicidin homologs in all available genomes including those completed recently. The organization of cathelicidin genes, as well as the secondary and tertiary structures of the inferred proteins are conserved. Based on integrated genomic, structural, and functional data, the author identified the last common ancestor of the cathelicidin family in lampreys, thus tracing the evolutionary origin of cathelicidins 550 million years ago. The authoŕs data suggest that cathelicidins arose concordantly with the adaptive immune system, a new organismal function first acquired in lampreys. The appearance of cathelicidins at the junction of innate and adaptive immunity may explain their dual roles as signal transducing molecules and as antimicrobial peptide precursors. Conserved regulatory elements associated with functions of the immune system were identified in cathelicidin gene promoter sequences invariably from fishes to humans | ||
| 653 | |a Adaptive Immunity |a Cathelicidins |a Cystatins |a Evolution |a Innate Immunity | ||
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10.4018/ijsbbt.2013040102 doi (DE-627)NLEJ251827755 (VZGNL)10.4018/ijsbbt.2013040102 DE-627 ger DE-627 rakwb eng Pavlopoulou, Athanasia verfasserin aut Cathelicidins Revisited Molecular Evolution, Structure and Functional Implications 2013 1 Online-Ressource Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Cathelicidins constitute important antimicrobial peptides of innate immunity. In order to elucidate the evolutionary history of cathelicidins, the author performed comprehensive phylogenetic analyses of cathelicidin homologs in all available genomes including those completed recently. The organization of cathelicidin genes, as well as the secondary and tertiary structures of the inferred proteins are conserved. Based on integrated genomic, structural, and functional data, the author identified the last common ancestor of the cathelicidin family in lampreys, thus tracing the evolutionary origin of cathelicidins 550 million years ago. The authoŕs data suggest that cathelicidins arose concordantly with the adaptive immune system, a new organismal function first acquired in lampreys. The appearance of cathelicidins at the junction of innate and adaptive immunity may explain their dual roles as signal transducing molecules and as antimicrobial peptide precursors. Conserved regulatory elements associated with functions of the immune system were identified in cathelicidin gene promoter sequences invariably from fishes to humans Adaptive Immunity Cathelicidins Cystatins Evolution Innate Immunity Enthalten in International journal of systems biology and biomedical technologies Hershey, Pa : IGI Global, 2012 2(2013), 2, Seite 8-32 Online-Ressource (DE-627)NLEJ244419450 (DE-600)2703840-3 2160-9594 nnns volume:2 year:2013 number:2 pages:8-32 http://services.igi-global.com/resolvedoi/resolve.aspx?doi=10.4018/ijsbbt.2013040102 X:IGIG Verlag Deutschlandweit zugänglich http://services.igi-global.com/resolvedoi/resolve.aspx?doi=10.4018/ijsbbt.2013040102&buylink=true Abstract ZDB-1-GIS GBV_NL_ARTICLE AR 2 2013 2 8-32 |
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10.4018/ijsbbt.2013040102 doi (DE-627)NLEJ251827755 (VZGNL)10.4018/ijsbbt.2013040102 DE-627 ger DE-627 rakwb eng Pavlopoulou, Athanasia verfasserin aut Cathelicidins Revisited Molecular Evolution, Structure and Functional Implications 2013 1 Online-Ressource Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Cathelicidins constitute important antimicrobial peptides of innate immunity. In order to elucidate the evolutionary history of cathelicidins, the author performed comprehensive phylogenetic analyses of cathelicidin homologs in all available genomes including those completed recently. The organization of cathelicidin genes, as well as the secondary and tertiary structures of the inferred proteins are conserved. Based on integrated genomic, structural, and functional data, the author identified the last common ancestor of the cathelicidin family in lampreys, thus tracing the evolutionary origin of cathelicidins 550 million years ago. The authoŕs data suggest that cathelicidins arose concordantly with the adaptive immune system, a new organismal function first acquired in lampreys. The appearance of cathelicidins at the junction of innate and adaptive immunity may explain their dual roles as signal transducing molecules and as antimicrobial peptide precursors. Conserved regulatory elements associated with functions of the immune system were identified in cathelicidin gene promoter sequences invariably from fishes to humans Adaptive Immunity Cathelicidins Cystatins Evolution Innate Immunity Enthalten in International journal of systems biology and biomedical technologies Hershey, Pa : IGI Global, 2012 2(2013), 2, Seite 8-32 Online-Ressource (DE-627)NLEJ244419450 (DE-600)2703840-3 2160-9594 nnns volume:2 year:2013 number:2 pages:8-32 http://services.igi-global.com/resolvedoi/resolve.aspx?doi=10.4018/ijsbbt.2013040102 X:IGIG Verlag Deutschlandweit zugänglich http://services.igi-global.com/resolvedoi/resolve.aspx?doi=10.4018/ijsbbt.2013040102&buylink=true Abstract ZDB-1-GIS GBV_NL_ARTICLE AR 2 2013 2 8-32 |
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10.4018/ijsbbt.2013040102 doi (DE-627)NLEJ251827755 (VZGNL)10.4018/ijsbbt.2013040102 DE-627 ger DE-627 rakwb eng Pavlopoulou, Athanasia verfasserin aut Cathelicidins Revisited Molecular Evolution, Structure and Functional Implications 2013 1 Online-Ressource Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Cathelicidins constitute important antimicrobial peptides of innate immunity. In order to elucidate the evolutionary history of cathelicidins, the author performed comprehensive phylogenetic analyses of cathelicidin homologs in all available genomes including those completed recently. The organization of cathelicidin genes, as well as the secondary and tertiary structures of the inferred proteins are conserved. Based on integrated genomic, structural, and functional data, the author identified the last common ancestor of the cathelicidin family in lampreys, thus tracing the evolutionary origin of cathelicidins 550 million years ago. The authoŕs data suggest that cathelicidins arose concordantly with the adaptive immune system, a new organismal function first acquired in lampreys. The appearance of cathelicidins at the junction of innate and adaptive immunity may explain their dual roles as signal transducing molecules and as antimicrobial peptide precursors. Conserved regulatory elements associated with functions of the immune system were identified in cathelicidin gene promoter sequences invariably from fishes to humans Adaptive Immunity Cathelicidins Cystatins Evolution Innate Immunity Enthalten in International journal of systems biology and biomedical technologies Hershey, Pa : IGI Global, 2012 2(2013), 2, Seite 8-32 Online-Ressource (DE-627)NLEJ244419450 (DE-600)2703840-3 2160-9594 nnns volume:2 year:2013 number:2 pages:8-32 http://services.igi-global.com/resolvedoi/resolve.aspx?doi=10.4018/ijsbbt.2013040102 X:IGIG Verlag Deutschlandweit zugänglich http://services.igi-global.com/resolvedoi/resolve.aspx?doi=10.4018/ijsbbt.2013040102&buylink=true Abstract ZDB-1-GIS GBV_NL_ARTICLE AR 2 2013 2 8-32 |
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10.4018/ijsbbt.2013040102 doi (DE-627)NLEJ251827755 (VZGNL)10.4018/ijsbbt.2013040102 DE-627 ger DE-627 rakwb eng Pavlopoulou, Athanasia verfasserin aut Cathelicidins Revisited Molecular Evolution, Structure and Functional Implications 2013 1 Online-Ressource Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Cathelicidins constitute important antimicrobial peptides of innate immunity. In order to elucidate the evolutionary history of cathelicidins, the author performed comprehensive phylogenetic analyses of cathelicidin homologs in all available genomes including those completed recently. The organization of cathelicidin genes, as well as the secondary and tertiary structures of the inferred proteins are conserved. Based on integrated genomic, structural, and functional data, the author identified the last common ancestor of the cathelicidin family in lampreys, thus tracing the evolutionary origin of cathelicidins 550 million years ago. The authoŕs data suggest that cathelicidins arose concordantly with the adaptive immune system, a new organismal function first acquired in lampreys. The appearance of cathelicidins at the junction of innate and adaptive immunity may explain their dual roles as signal transducing molecules and as antimicrobial peptide precursors. Conserved regulatory elements associated with functions of the immune system were identified in cathelicidin gene promoter sequences invariably from fishes to humans Adaptive Immunity Cathelicidins Cystatins Evolution Innate Immunity Enthalten in International journal of systems biology and biomedical technologies Hershey, Pa : IGI Global, 2012 2(2013), 2, Seite 8-32 Online-Ressource (DE-627)NLEJ244419450 (DE-600)2703840-3 2160-9594 nnns volume:2 year:2013 number:2 pages:8-32 http://services.igi-global.com/resolvedoi/resolve.aspx?doi=10.4018/ijsbbt.2013040102 X:IGIG Verlag Deutschlandweit zugänglich http://services.igi-global.com/resolvedoi/resolve.aspx?doi=10.4018/ijsbbt.2013040102&buylink=true Abstract ZDB-1-GIS GBV_NL_ARTICLE AR 2 2013 2 8-32 |
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Cathelicidins constitute important antimicrobial peptides of innate immunity. In order to elucidate the evolutionary history of cathelicidins, the author performed comprehensive phylogenetic analyses of cathelicidin homologs in all available genomes including those completed recently. The organization of cathelicidin genes, as well as the secondary and tertiary structures of the inferred proteins are conserved. Based on integrated genomic, structural, and functional data, the author identified the last common ancestor of the cathelicidin family in lampreys, thus tracing the evolutionary origin of cathelicidins 550 million years ago. The authoŕs data suggest that cathelicidins arose concordantly with the adaptive immune system, a new organismal function first acquired in lampreys. The appearance of cathelicidins at the junction of innate and adaptive immunity may explain their dual roles as signal transducing molecules and as antimicrobial peptide precursors. Conserved regulatory elements associated with functions of the immune system were identified in cathelicidin gene promoter sequences invariably from fishes to humans |
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Cathelicidins constitute important antimicrobial peptides of innate immunity. In order to elucidate the evolutionary history of cathelicidins, the author performed comprehensive phylogenetic analyses of cathelicidin homologs in all available genomes including those completed recently. The organization of cathelicidin genes, as well as the secondary and tertiary structures of the inferred proteins are conserved. Based on integrated genomic, structural, and functional data, the author identified the last common ancestor of the cathelicidin family in lampreys, thus tracing the evolutionary origin of cathelicidins 550 million years ago. The authoŕs data suggest that cathelicidins arose concordantly with the adaptive immune system, a new organismal function first acquired in lampreys. The appearance of cathelicidins at the junction of innate and adaptive immunity may explain their dual roles as signal transducing molecules and as antimicrobial peptide precursors. Conserved regulatory elements associated with functions of the immune system were identified in cathelicidin gene promoter sequences invariably from fishes to humans |
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Cathelicidins constitute important antimicrobial peptides of innate immunity. In order to elucidate the evolutionary history of cathelicidins, the author performed comprehensive phylogenetic analyses of cathelicidin homologs in all available genomes including those completed recently. The organization of cathelicidin genes, as well as the secondary and tertiary structures of the inferred proteins are conserved. Based on integrated genomic, structural, and functional data, the author identified the last common ancestor of the cathelicidin family in lampreys, thus tracing the evolutionary origin of cathelicidins 550 million years ago. The authoŕs data suggest that cathelicidins arose concordantly with the adaptive immune system, a new organismal function first acquired in lampreys. The appearance of cathelicidins at the junction of innate and adaptive immunity may explain their dual roles as signal transducing molecules and as antimicrobial peptide precursors. Conserved regulatory elements associated with functions of the immune system were identified in cathelicidin gene promoter sequences invariably from fishes to humans |
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