Optimization of Long-Range Surface Plasmon Waveguides for Attenuation-Based Biosensing
The design and optimization of straight long-range surface plasmon waveguides to maximize attenuation surface sensitivity in biochemical sensing applications are discussed. The sensor consists of a Au stripe embedded in CYTOP, with a microfluidic channel etched into the top cladding to expose the su...
Ausführliche Beschreibung
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| Autor*in: |
Wei Ru Wong [verfasserIn] |
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| Format: |
Artikel |
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| Sprache: |
Englisch |
| Erschienen: |
2015 |
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| Schlagwörter: |
attenuation surface sensitivity biochemical sensing applications |
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| Übergeordnetes Werk: |
Enthalten in: Journal of lightwave technology - New York, NY : IEEE, 1983, 33(2015), 15, Seite 3234-3242 |
|---|---|
| Übergeordnetes Werk: |
volume:33 ; year:2015 ; number:15 ; pages:3234-3242 |
| Links: |
|---|
| DOI / URN: |
10.1109/JLT.2015.2431612 |
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OLC1956640436 |
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| 520 | |a The design and optimization of straight long-range surface plasmon waveguides to maximize attenuation surface sensitivity in biochemical sensing applications are discussed. The sensor consists of a Au stripe embedded in CYTOP, with a microfluidic channel etched into the top cladding to expose the surface of the Au stripe and define the sensing channel. The attenuation α s of the structure changes as a biological adlayer grows on the Au surface. The dimensions of the stripe (thickness, width), the sensing length and the refractive index of the sensing buffer were varied in order to understand their impact on sensor performance. The attenuation sensitivity ∂α s /∂a dominates over a wide range of waveguide designs, so we define a parameter K = (∂α s /∂a)/αs where maximizing |K| and selecting the optimal sensing length as L opt = 1/(2α s ) maximizes the overall sensitivity of the structure. Experimental results based on observing the physisorption of bovine serum albumin (BSA) on bare Au waveguides agree qualitatively and quantitatively with theory. Detection limits of ΔΓ min <; 0.1 pg·mm -2 are predicted for optimal designs, and a detection limit of ΔΓ min = 4.1pg/mm 2 (SNR = 1) is demonstrated experimentally for a sub-optimal structure. | ||
| 650 | 4 | |a biosensors | |
| 650 | 4 | |a optical waveguides | |
| 650 | 4 | |a attenuation-based biosensing | |
| 650 | 4 | |a attenuation sensitivity | |
| 650 | 4 | |a Surface waves | |
| 650 | 4 | |a microsensors | |
| 650 | 4 | |a attenuation surface sensitivity | |
| 650 | 4 | |a biochemical sensing applications | |
| 650 | 4 | |a biosensor | |
| 650 | 4 | |a top cladding | |
| 650 | 4 | |a light attenuation | |
| 650 | 4 | |a attenuation | |
| 650 | 4 | |a surface plasmons | |
| 650 | 4 | |a long-range surface plasmon waveguide design | |
| 650 | 4 | |a micro-optomechanical devices | |
| 650 | 4 | |a microfluidic channel | |
| 650 | 4 | |a gold | |
| 650 | 4 | |a Sensitivity | |
| 650 | 4 | |a optimal sensing length | |
| 650 | 4 | |a BSA | |
| 650 | 4 | |a bovine serum albumin | |
| 650 | 4 | |a optimization | |
| 650 | 4 | |a molecular biophysics | |
| 650 | 4 | |a adsorption | |
| 650 | 4 | |a Optical surface waves | |
| 650 | 4 | |a Surface plasmon | |
| 650 | 4 | |a microchannel flow | |
| 650 | 4 | |a CYTOP | |
| 650 | 4 | |a biological adlayer | |
| 650 | 4 | |a stripe thickness | |
| 650 | 4 | |a sensing length | |
| 650 | 4 | |a stripe thickness width | |
| 650 | 4 | |a physisorption | |
| 650 | 4 | |a proteins | |
| 650 | 4 | |a optical design techniques | |
| 650 | 4 | |a refractive index | |
| 650 | 4 | |a optimisation | |
| 700 | 1 | |a Krupin, Oleksiy |4 oth | |
| 700 | 1 | |a Mahamd Adikan, Faisal Rafiq |4 oth | |
| 700 | 1 | |a Berini, Pierre |4 oth | |
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10.1109/JLT.2015.2431612 doi PQ20160617 (DE-627)OLC1956640436 (DE-599)GBVOLC1956640436 (PRQ)c1301-36ac96f1983a95f21e58d7a6441ae142dd363d2571b89fb8c546c618b98cac1b0 (KEY)0124889820150000033001503234optimizationoflongrangesurfaceplasmonwaveguidesfor DE-627 ger DE-627 rakwb eng 530 600 620 DNB Wei Ru Wong verfasserin aut Optimization of Long-Range Surface Plasmon Waveguides for Attenuation-Based Biosensing 2015 Text txt rdacontent ohne Hilfsmittel zu benutzen n rdamedia Band nc rdacarrier The design and optimization of straight long-range surface plasmon waveguides to maximize attenuation surface sensitivity in biochemical sensing applications are discussed. The sensor consists of a Au stripe embedded in CYTOP, with a microfluidic channel etched into the top cladding to expose the surface of the Au stripe and define the sensing channel. The attenuation α s of the structure changes as a biological adlayer grows on the Au surface. The dimensions of the stripe (thickness, width), the sensing length and the refractive index of the sensing buffer were varied in order to understand their impact on sensor performance. The attenuation sensitivity ∂α s /∂a dominates over a wide range of waveguide designs, so we define a parameter K = (∂α s /∂a)/αs where maximizing |K| and selecting the optimal sensing length as L opt = 1/(2α s ) maximizes the overall sensitivity of the structure. Experimental results based on observing the physisorption of bovine serum albumin (BSA) on bare Au waveguides agree qualitatively and quantitatively with theory. Detection limits of ΔΓ min <; 0.1 pg·mm -2 are predicted for optimal designs, and a detection limit of ΔΓ min = 4.1pg/mm 2 (SNR = 1) is demonstrated experimentally for a sub-optimal structure. biosensors optical waveguides attenuation-based biosensing attenuation sensitivity Surface waves microsensors attenuation surface sensitivity biochemical sensing applications biosensor top cladding light attenuation attenuation surface plasmons long-range surface plasmon waveguide design micro-optomechanical devices microfluidic channel gold Sensitivity optimal sensing length BSA bovine serum albumin optimization molecular biophysics adsorption Optical surface waves Surface plasmon microchannel flow CYTOP biological adlayer stripe thickness sensing length stripe thickness width physisorption proteins optical design techniques refractive index optimisation Krupin, Oleksiy oth Mahamd Adikan, Faisal Rafiq oth Berini, Pierre oth Enthalten in Journal of lightwave technology New York, NY : IEEE, 1983 33(2015), 15, Seite 3234-3242 (DE-627)129620882 (DE-600)246121-3 (DE-576)015127214 0733-8724 nnns volume:33 year:2015 number:15 pages:3234-3242 http://dx.doi.org/10.1109/JLT.2015.2431612 Volltext http://ieeexplore.ieee.org/xpls/abs_all.jsp?arnumber=7104097 GBV_USEFLAG_A SYSFLAG_A GBV_OLC SSG-OLC-TEC SSG-OLC-PHY GBV_ILN_70 GBV_ILN_170 GBV_ILN_185 GBV_ILN_4318 AR 33 2015 15 3234-3242 |
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10.1109/JLT.2015.2431612 doi PQ20160617 (DE-627)OLC1956640436 (DE-599)GBVOLC1956640436 (PRQ)c1301-36ac96f1983a95f21e58d7a6441ae142dd363d2571b89fb8c546c618b98cac1b0 (KEY)0124889820150000033001503234optimizationoflongrangesurfaceplasmonwaveguidesfor DE-627 ger DE-627 rakwb eng 530 600 620 DNB Wei Ru Wong verfasserin aut Optimization of Long-Range Surface Plasmon Waveguides for Attenuation-Based Biosensing 2015 Text txt rdacontent ohne Hilfsmittel zu benutzen n rdamedia Band nc rdacarrier The design and optimization of straight long-range surface plasmon waveguides to maximize attenuation surface sensitivity in biochemical sensing applications are discussed. The sensor consists of a Au stripe embedded in CYTOP, with a microfluidic channel etched into the top cladding to expose the surface of the Au stripe and define the sensing channel. The attenuation α s of the structure changes as a biological adlayer grows on the Au surface. The dimensions of the stripe (thickness, width), the sensing length and the refractive index of the sensing buffer were varied in order to understand their impact on sensor performance. The attenuation sensitivity ∂α s /∂a dominates over a wide range of waveguide designs, so we define a parameter K = (∂α s /∂a)/αs where maximizing |K| and selecting the optimal sensing length as L opt = 1/(2α s ) maximizes the overall sensitivity of the structure. Experimental results based on observing the physisorption of bovine serum albumin (BSA) on bare Au waveguides agree qualitatively and quantitatively with theory. Detection limits of ΔΓ min <; 0.1 pg·mm -2 are predicted for optimal designs, and a detection limit of ΔΓ min = 4.1pg/mm 2 (SNR = 1) is demonstrated experimentally for a sub-optimal structure. biosensors optical waveguides attenuation-based biosensing attenuation sensitivity Surface waves microsensors attenuation surface sensitivity biochemical sensing applications biosensor top cladding light attenuation attenuation surface plasmons long-range surface plasmon waveguide design micro-optomechanical devices microfluidic channel gold Sensitivity optimal sensing length BSA bovine serum albumin optimization molecular biophysics adsorption Optical surface waves Surface plasmon microchannel flow CYTOP biological adlayer stripe thickness sensing length stripe thickness width physisorption proteins optical design techniques refractive index optimisation Krupin, Oleksiy oth Mahamd Adikan, Faisal Rafiq oth Berini, Pierre oth Enthalten in Journal of lightwave technology New York, NY : IEEE, 1983 33(2015), 15, Seite 3234-3242 (DE-627)129620882 (DE-600)246121-3 (DE-576)015127214 0733-8724 nnns volume:33 year:2015 number:15 pages:3234-3242 http://dx.doi.org/10.1109/JLT.2015.2431612 Volltext http://ieeexplore.ieee.org/xpls/abs_all.jsp?arnumber=7104097 GBV_USEFLAG_A SYSFLAG_A GBV_OLC SSG-OLC-TEC SSG-OLC-PHY GBV_ILN_70 GBV_ILN_170 GBV_ILN_185 GBV_ILN_4318 AR 33 2015 15 3234-3242 |
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10.1109/JLT.2015.2431612 doi PQ20160617 (DE-627)OLC1956640436 (DE-599)GBVOLC1956640436 (PRQ)c1301-36ac96f1983a95f21e58d7a6441ae142dd363d2571b89fb8c546c618b98cac1b0 (KEY)0124889820150000033001503234optimizationoflongrangesurfaceplasmonwaveguidesfor DE-627 ger DE-627 rakwb eng 530 600 620 DNB Wei Ru Wong verfasserin aut Optimization of Long-Range Surface Plasmon Waveguides for Attenuation-Based Biosensing 2015 Text txt rdacontent ohne Hilfsmittel zu benutzen n rdamedia Band nc rdacarrier The design and optimization of straight long-range surface plasmon waveguides to maximize attenuation surface sensitivity in biochemical sensing applications are discussed. The sensor consists of a Au stripe embedded in CYTOP, with a microfluidic channel etched into the top cladding to expose the surface of the Au stripe and define the sensing channel. The attenuation α s of the structure changes as a biological adlayer grows on the Au surface. The dimensions of the stripe (thickness, width), the sensing length and the refractive index of the sensing buffer were varied in order to understand their impact on sensor performance. The attenuation sensitivity ∂α s /∂a dominates over a wide range of waveguide designs, so we define a parameter K = (∂α s /∂a)/αs where maximizing |K| and selecting the optimal sensing length as L opt = 1/(2α s ) maximizes the overall sensitivity of the structure. Experimental results based on observing the physisorption of bovine serum albumin (BSA) on bare Au waveguides agree qualitatively and quantitatively with theory. Detection limits of ΔΓ min <; 0.1 pg·mm -2 are predicted for optimal designs, and a detection limit of ΔΓ min = 4.1pg/mm 2 (SNR = 1) is demonstrated experimentally for a sub-optimal structure. biosensors optical waveguides attenuation-based biosensing attenuation sensitivity Surface waves microsensors attenuation surface sensitivity biochemical sensing applications biosensor top cladding light attenuation attenuation surface plasmons long-range surface plasmon waveguide design micro-optomechanical devices microfluidic channel gold Sensitivity optimal sensing length BSA bovine serum albumin optimization molecular biophysics adsorption Optical surface waves Surface plasmon microchannel flow CYTOP biological adlayer stripe thickness sensing length stripe thickness width physisorption proteins optical design techniques refractive index optimisation Krupin, Oleksiy oth Mahamd Adikan, Faisal Rafiq oth Berini, Pierre oth Enthalten in Journal of lightwave technology New York, NY : IEEE, 1983 33(2015), 15, Seite 3234-3242 (DE-627)129620882 (DE-600)246121-3 (DE-576)015127214 0733-8724 nnns volume:33 year:2015 number:15 pages:3234-3242 http://dx.doi.org/10.1109/JLT.2015.2431612 Volltext http://ieeexplore.ieee.org/xpls/abs_all.jsp?arnumber=7104097 GBV_USEFLAG_A SYSFLAG_A GBV_OLC SSG-OLC-TEC SSG-OLC-PHY GBV_ILN_70 GBV_ILN_170 GBV_ILN_185 GBV_ILN_4318 AR 33 2015 15 3234-3242 |
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10.1109/JLT.2015.2431612 doi PQ20160617 (DE-627)OLC1956640436 (DE-599)GBVOLC1956640436 (PRQ)c1301-36ac96f1983a95f21e58d7a6441ae142dd363d2571b89fb8c546c618b98cac1b0 (KEY)0124889820150000033001503234optimizationoflongrangesurfaceplasmonwaveguidesfor DE-627 ger DE-627 rakwb eng 530 600 620 DNB Wei Ru Wong verfasserin aut Optimization of Long-Range Surface Plasmon Waveguides for Attenuation-Based Biosensing 2015 Text txt rdacontent ohne Hilfsmittel zu benutzen n rdamedia Band nc rdacarrier The design and optimization of straight long-range surface plasmon waveguides to maximize attenuation surface sensitivity in biochemical sensing applications are discussed. The sensor consists of a Au stripe embedded in CYTOP, with a microfluidic channel etched into the top cladding to expose the surface of the Au stripe and define the sensing channel. The attenuation α s of the structure changes as a biological adlayer grows on the Au surface. The dimensions of the stripe (thickness, width), the sensing length and the refractive index of the sensing buffer were varied in order to understand their impact on sensor performance. The attenuation sensitivity ∂α s /∂a dominates over a wide range of waveguide designs, so we define a parameter K = (∂α s /∂a)/αs where maximizing |K| and selecting the optimal sensing length as L opt = 1/(2α s ) maximizes the overall sensitivity of the structure. Experimental results based on observing the physisorption of bovine serum albumin (BSA) on bare Au waveguides agree qualitatively and quantitatively with theory. Detection limits of ΔΓ min <; 0.1 pg·mm -2 are predicted for optimal designs, and a detection limit of ΔΓ min = 4.1pg/mm 2 (SNR = 1) is demonstrated experimentally for a sub-optimal structure. biosensors optical waveguides attenuation-based biosensing attenuation sensitivity Surface waves microsensors attenuation surface sensitivity biochemical sensing applications biosensor top cladding light attenuation attenuation surface plasmons long-range surface plasmon waveguide design micro-optomechanical devices microfluidic channel gold Sensitivity optimal sensing length BSA bovine serum albumin optimization molecular biophysics adsorption Optical surface waves Surface plasmon microchannel flow CYTOP biological adlayer stripe thickness sensing length stripe thickness width physisorption proteins optical design techniques refractive index optimisation Krupin, Oleksiy oth Mahamd Adikan, Faisal Rafiq oth Berini, Pierre oth Enthalten in Journal of lightwave technology New York, NY : IEEE, 1983 33(2015), 15, Seite 3234-3242 (DE-627)129620882 (DE-600)246121-3 (DE-576)015127214 0733-8724 nnns volume:33 year:2015 number:15 pages:3234-3242 http://dx.doi.org/10.1109/JLT.2015.2431612 Volltext http://ieeexplore.ieee.org/xpls/abs_all.jsp?arnumber=7104097 GBV_USEFLAG_A SYSFLAG_A GBV_OLC SSG-OLC-TEC SSG-OLC-PHY GBV_ILN_70 GBV_ILN_170 GBV_ILN_185 GBV_ILN_4318 AR 33 2015 15 3234-3242 |
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10.1109/JLT.2015.2431612 doi PQ20160617 (DE-627)OLC1956640436 (DE-599)GBVOLC1956640436 (PRQ)c1301-36ac96f1983a95f21e58d7a6441ae142dd363d2571b89fb8c546c618b98cac1b0 (KEY)0124889820150000033001503234optimizationoflongrangesurfaceplasmonwaveguidesfor DE-627 ger DE-627 rakwb eng 530 600 620 DNB Wei Ru Wong verfasserin aut Optimization of Long-Range Surface Plasmon Waveguides for Attenuation-Based Biosensing 2015 Text txt rdacontent ohne Hilfsmittel zu benutzen n rdamedia Band nc rdacarrier The design and optimization of straight long-range surface plasmon waveguides to maximize attenuation surface sensitivity in biochemical sensing applications are discussed. The sensor consists of a Au stripe embedded in CYTOP, with a microfluidic channel etched into the top cladding to expose the surface of the Au stripe and define the sensing channel. The attenuation α s of the structure changes as a biological adlayer grows on the Au surface. The dimensions of the stripe (thickness, width), the sensing length and the refractive index of the sensing buffer were varied in order to understand their impact on sensor performance. The attenuation sensitivity ∂α s /∂a dominates over a wide range of waveguide designs, so we define a parameter K = (∂α s /∂a)/αs where maximizing |K| and selecting the optimal sensing length as L opt = 1/(2α s ) maximizes the overall sensitivity of the structure. Experimental results based on observing the physisorption of bovine serum albumin (BSA) on bare Au waveguides agree qualitatively and quantitatively with theory. Detection limits of ΔΓ min <; 0.1 pg·mm -2 are predicted for optimal designs, and a detection limit of ΔΓ min = 4.1pg/mm 2 (SNR = 1) is demonstrated experimentally for a sub-optimal structure. biosensors optical waveguides attenuation-based biosensing attenuation sensitivity Surface waves microsensors attenuation surface sensitivity biochemical sensing applications biosensor top cladding light attenuation attenuation surface plasmons long-range surface plasmon waveguide design micro-optomechanical devices microfluidic channel gold Sensitivity optimal sensing length BSA bovine serum albumin optimization molecular biophysics adsorption Optical surface waves Surface plasmon microchannel flow CYTOP biological adlayer stripe thickness sensing length stripe thickness width physisorption proteins optical design techniques refractive index optimisation Krupin, Oleksiy oth Mahamd Adikan, Faisal Rafiq oth Berini, Pierre oth Enthalten in Journal of lightwave technology New York, NY : IEEE, 1983 33(2015), 15, Seite 3234-3242 (DE-627)129620882 (DE-600)246121-3 (DE-576)015127214 0733-8724 nnns volume:33 year:2015 number:15 pages:3234-3242 http://dx.doi.org/10.1109/JLT.2015.2431612 Volltext http://ieeexplore.ieee.org/xpls/abs_all.jsp?arnumber=7104097 GBV_USEFLAG_A SYSFLAG_A GBV_OLC SSG-OLC-TEC SSG-OLC-PHY GBV_ILN_70 GBV_ILN_170 GBV_ILN_185 GBV_ILN_4318 AR 33 2015 15 3234-3242 |
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Wei Ru Wong |
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Wei Ru Wong ddc 530 misc biosensors misc optical waveguides misc attenuation-based biosensing misc attenuation sensitivity misc Surface waves misc microsensors misc attenuation surface sensitivity misc biochemical sensing applications misc biosensor misc top cladding misc light attenuation misc attenuation misc surface plasmons misc long-range surface plasmon waveguide design misc micro-optomechanical devices misc microfluidic channel misc gold misc Sensitivity misc optimal sensing length misc BSA misc bovine serum albumin misc optimization misc molecular biophysics misc adsorption misc Optical surface waves misc Surface plasmon misc microchannel flow misc CYTOP misc biological adlayer misc stripe thickness misc sensing length misc stripe thickness width misc physisorption misc proteins misc optical design techniques misc refractive index misc optimisation Optimization of Long-Range Surface Plasmon Waveguides for Attenuation-Based Biosensing |
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530 600 620 DNB Optimization of Long-Range Surface Plasmon Waveguides for Attenuation-Based Biosensing biosensors optical waveguides attenuation-based biosensing attenuation sensitivity Surface waves microsensors attenuation surface sensitivity biochemical sensing applications biosensor top cladding light attenuation attenuation surface plasmons long-range surface plasmon waveguide design micro-optomechanical devices microfluidic channel gold Sensitivity optimal sensing length BSA bovine serum albumin optimization molecular biophysics adsorption Optical surface waves Surface plasmon microchannel flow CYTOP biological adlayer stripe thickness sensing length stripe thickness width physisorption proteins optical design techniques refractive index optimisation |
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ddc 530 misc biosensors misc optical waveguides misc attenuation-based biosensing misc attenuation sensitivity misc Surface waves misc microsensors misc attenuation surface sensitivity misc biochemical sensing applications misc biosensor misc top cladding misc light attenuation misc attenuation misc surface plasmons misc long-range surface plasmon waveguide design misc micro-optomechanical devices misc microfluidic channel misc gold misc Sensitivity misc optimal sensing length misc BSA misc bovine serum albumin misc optimization misc molecular biophysics misc adsorption misc Optical surface waves misc Surface plasmon misc microchannel flow misc CYTOP misc biological adlayer misc stripe thickness misc sensing length misc stripe thickness width misc physisorption misc proteins misc optical design techniques misc refractive index misc optimisation |
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Optimization of Long-Range Surface Plasmon Waveguides for Attenuation-Based Biosensing |
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The design and optimization of straight long-range surface plasmon waveguides to maximize attenuation surface sensitivity in biochemical sensing applications are discussed. The sensor consists of a Au stripe embedded in CYTOP, with a microfluidic channel etched into the top cladding to expose the surface of the Au stripe and define the sensing channel. The attenuation α s of the structure changes as a biological adlayer grows on the Au surface. The dimensions of the stripe (thickness, width), the sensing length and the refractive index of the sensing buffer were varied in order to understand their impact on sensor performance. The attenuation sensitivity ∂α s /∂a dominates over a wide range of waveguide designs, so we define a parameter K = (∂α s /∂a)/αs where maximizing |K| and selecting the optimal sensing length as L opt = 1/(2α s ) maximizes the overall sensitivity of the structure. Experimental results based on observing the physisorption of bovine serum albumin (BSA) on bare Au waveguides agree qualitatively and quantitatively with theory. Detection limits of ΔΓ min <; 0.1 pg·mm -2 are predicted for optimal designs, and a detection limit of ΔΓ min = 4.1pg/mm 2 (SNR = 1) is demonstrated experimentally for a sub-optimal structure. |
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The design and optimization of straight long-range surface plasmon waveguides to maximize attenuation surface sensitivity in biochemical sensing applications are discussed. The sensor consists of a Au stripe embedded in CYTOP, with a microfluidic channel etched into the top cladding to expose the surface of the Au stripe and define the sensing channel. The attenuation α s of the structure changes as a biological adlayer grows on the Au surface. The dimensions of the stripe (thickness, width), the sensing length and the refractive index of the sensing buffer were varied in order to understand their impact on sensor performance. The attenuation sensitivity ∂α s /∂a dominates over a wide range of waveguide designs, so we define a parameter K = (∂α s /∂a)/αs where maximizing |K| and selecting the optimal sensing length as L opt = 1/(2α s ) maximizes the overall sensitivity of the structure. Experimental results based on observing the physisorption of bovine serum albumin (BSA) on bare Au waveguides agree qualitatively and quantitatively with theory. Detection limits of ΔΓ min <; 0.1 pg·mm -2 are predicted for optimal designs, and a detection limit of ΔΓ min = 4.1pg/mm 2 (SNR = 1) is demonstrated experimentally for a sub-optimal structure. |
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The design and optimization of straight long-range surface plasmon waveguides to maximize attenuation surface sensitivity in biochemical sensing applications are discussed. The sensor consists of a Au stripe embedded in CYTOP, with a microfluidic channel etched into the top cladding to expose the surface of the Au stripe and define the sensing channel. The attenuation α s of the structure changes as a biological adlayer grows on the Au surface. The dimensions of the stripe (thickness, width), the sensing length and the refractive index of the sensing buffer were varied in order to understand their impact on sensor performance. The attenuation sensitivity ∂α s /∂a dominates over a wide range of waveguide designs, so we define a parameter K = (∂α s /∂a)/αs where maximizing |K| and selecting the optimal sensing length as L opt = 1/(2α s ) maximizes the overall sensitivity of the structure. Experimental results based on observing the physisorption of bovine serum albumin (BSA) on bare Au waveguides agree qualitatively and quantitatively with theory. Detection limits of ΔΓ min <; 0.1 pg·mm -2 are predicted for optimal designs, and a detection limit of ΔΓ min = 4.1pg/mm 2 (SNR = 1) is demonstrated experimentally for a sub-optimal structure. |
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Optimization of Long-Range Surface Plasmon Waveguides for Attenuation-Based Biosensing |
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