Thermodynamics-based design of microbial cell factories for anaerobic product formation
The field of metabolic engineering has delivered new microbial cell factories and processes for the production of different compounds including biofuels, (di)carboxylic acids, alcohols, and amino acids. Most of these processes are aerobic, with few exceptions (e.g., alcoholic fermentation), and atte...
Ausführliche Beschreibung
Gespeichert in:
| Autor*in: |
Cueto-Rojas, Hugo F [verfasserIn] |
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| Format: |
Artikel |
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| Sprache: |
Englisch |
| Erschienen: |
2015 |
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| Rechteinformationen: |
Nutzungsrecht: Copyright © 2015 Elsevier Ltd. All rights reserved. |
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| Schlagwörter: |
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| Übergeordnetes Werk: |
Enthalten in: Trends in biotechnology - Cambridge : Elsevier, 1983, 33(2015), 9, Seite 534-546 |
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| Übergeordnetes Werk: |
volume:33 ; year:2015 ; number:9 ; pages:534-546 |
| Links: |
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| DOI / URN: |
10.1016/j.tibtech.2015.06.010 |
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| 520 | |a The field of metabolic engineering has delivered new microbial cell factories and processes for the production of different compounds including biofuels, (di)carboxylic acids, alcohols, and amino acids. Most of these processes are aerobic, with few exceptions (e.g., alcoholic fermentation), and attention is focused on assembling a high-flux product pathway with a production limit usually set by the oxygen transfer rate. By contrast, anaerobic product synthesis offers significant benefits compared to aerobic systems: higher yields, less heat generation, reduced biomass production, and lower mechanical energy input, which can significantly reduce production costs. Using simple thermodynamic calculations, we demonstrate that many products can theoretically be produced under anaerobic conditions using several conventional and non-conventional substrates. | ||
| 540 | |a Nutzungsrecht: Copyright © 2015 Elsevier Ltd. All rights reserved. | ||
| 650 | 4 | |a bioprocess design | |
| 650 | 4 | |a microbial cell factories | |
| 650 | 4 | |a Agricultural production | |
| 650 | 4 | |a Food | |
| 650 | 4 | |a Alternative energy sources | |
| 650 | 4 | |a Solvents | |
| 650 | 4 | |a Glucose | |
| 650 | 4 | |a Raw materials | |
| 650 | 4 | |a Costs | |
| 650 | 4 | |a Synthesis gas | |
| 650 | 4 | |a Factories | |
| 650 | 4 | |a Glycerol | |
| 650 | 4 | |a anaerobic product formation | |
| 650 | 4 | |a Aqueous solutions | |
| 650 | 4 | |a thermodynamics | |
| 650 | 4 | |a Ethanol | |
| 700 | 1 | |a van Maris, A J A |4 oth | |
| 700 | 1 | |a Wahl, S Aljoscha |4 oth | |
| 700 | 1 | |a Heijnen, J J |4 oth | |
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10.1016/j.tibtech.2015.06.010 doi PQ20160617 (DE-627)OLC195675413X (DE-599)GBVOLC195675413X (PRQ)c2163-eb7bf09a0d494b5f229d505ed07a939da1b1f4af107d432fcd035986b0ace90d0 (KEY)0131566820150000033000900534thermodynamicsbaseddesignofmicrobialcellfactoriesf DE-627 ger DE-627 rakwb eng 570 DNB 58.30 bkl Cueto-Rojas, Hugo F verfasserin aut Thermodynamics-based design of microbial cell factories for anaerobic product formation 2015 Text txt rdacontent ohne Hilfsmittel zu benutzen n rdamedia Band nc rdacarrier The field of metabolic engineering has delivered new microbial cell factories and processes for the production of different compounds including biofuels, (di)carboxylic acids, alcohols, and amino acids. Most of these processes are aerobic, with few exceptions (e.g., alcoholic fermentation), and attention is focused on assembling a high-flux product pathway with a production limit usually set by the oxygen transfer rate. By contrast, anaerobic product synthesis offers significant benefits compared to aerobic systems: higher yields, less heat generation, reduced biomass production, and lower mechanical energy input, which can significantly reduce production costs. Using simple thermodynamic calculations, we demonstrate that many products can theoretically be produced under anaerobic conditions using several conventional and non-conventional substrates. Nutzungsrecht: Copyright © 2015 Elsevier Ltd. All rights reserved. bioprocess design microbial cell factories Agricultural production Food Alternative energy sources Solvents Glucose Raw materials Costs Synthesis gas Factories Glycerol anaerobic product formation Aqueous solutions thermodynamics Ethanol van Maris, A J A oth Wahl, S Aljoscha oth Heijnen, J J oth Enthalten in Trends in biotechnology Cambridge : Elsevier, 1983 33(2015), 9, Seite 534-546 (DE-627)129140708 (DE-600)47474-5 (DE-576)014453339 0167-7799 nnns volume:33 year:2015 number:9 pages:534-546 http://dx.doi.org/10.1016/j.tibtech.2015.06.010 Volltext http://www.ncbi.nlm.nih.gov/pubmed/26232033 http://search.proquest.com/docview/1708154379 GBV_USEFLAG_A SYSFLAG_A GBV_OLC SSG-OLC-TEC SSG-OLC-CHE SSG-OLC-PHA SSG-OLC-DE-84 SSG-OPC-FOR GBV_ILN_70 GBV_ILN_252 GBV_ILN_2004 GBV_ILN_2016 GBV_ILN_2219 GBV_ILN_4029 58.30 AVZ AR 33 2015 9 534-546 |
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10.1016/j.tibtech.2015.06.010 doi PQ20160617 (DE-627)OLC195675413X (DE-599)GBVOLC195675413X (PRQ)c2163-eb7bf09a0d494b5f229d505ed07a939da1b1f4af107d432fcd035986b0ace90d0 (KEY)0131566820150000033000900534thermodynamicsbaseddesignofmicrobialcellfactoriesf DE-627 ger DE-627 rakwb eng 570 DNB 58.30 bkl Cueto-Rojas, Hugo F verfasserin aut Thermodynamics-based design of microbial cell factories for anaerobic product formation 2015 Text txt rdacontent ohne Hilfsmittel zu benutzen n rdamedia Band nc rdacarrier The field of metabolic engineering has delivered new microbial cell factories and processes for the production of different compounds including biofuels, (di)carboxylic acids, alcohols, and amino acids. Most of these processes are aerobic, with few exceptions (e.g., alcoholic fermentation), and attention is focused on assembling a high-flux product pathway with a production limit usually set by the oxygen transfer rate. By contrast, anaerobic product synthesis offers significant benefits compared to aerobic systems: higher yields, less heat generation, reduced biomass production, and lower mechanical energy input, which can significantly reduce production costs. Using simple thermodynamic calculations, we demonstrate that many products can theoretically be produced under anaerobic conditions using several conventional and non-conventional substrates. Nutzungsrecht: Copyright © 2015 Elsevier Ltd. All rights reserved. bioprocess design microbial cell factories Agricultural production Food Alternative energy sources Solvents Glucose Raw materials Costs Synthesis gas Factories Glycerol anaerobic product formation Aqueous solutions thermodynamics Ethanol van Maris, A J A oth Wahl, S Aljoscha oth Heijnen, J J oth Enthalten in Trends in biotechnology Cambridge : Elsevier, 1983 33(2015), 9, Seite 534-546 (DE-627)129140708 (DE-600)47474-5 (DE-576)014453339 0167-7799 nnns volume:33 year:2015 number:9 pages:534-546 http://dx.doi.org/10.1016/j.tibtech.2015.06.010 Volltext http://www.ncbi.nlm.nih.gov/pubmed/26232033 http://search.proquest.com/docview/1708154379 GBV_USEFLAG_A SYSFLAG_A GBV_OLC SSG-OLC-TEC SSG-OLC-CHE SSG-OLC-PHA SSG-OLC-DE-84 SSG-OPC-FOR GBV_ILN_70 GBV_ILN_252 GBV_ILN_2004 GBV_ILN_2016 GBV_ILN_2219 GBV_ILN_4029 58.30 AVZ AR 33 2015 9 534-546 |
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10.1016/j.tibtech.2015.06.010 doi PQ20160617 (DE-627)OLC195675413X (DE-599)GBVOLC195675413X (PRQ)c2163-eb7bf09a0d494b5f229d505ed07a939da1b1f4af107d432fcd035986b0ace90d0 (KEY)0131566820150000033000900534thermodynamicsbaseddesignofmicrobialcellfactoriesf DE-627 ger DE-627 rakwb eng 570 DNB 58.30 bkl Cueto-Rojas, Hugo F verfasserin aut Thermodynamics-based design of microbial cell factories for anaerobic product formation 2015 Text txt rdacontent ohne Hilfsmittel zu benutzen n rdamedia Band nc rdacarrier The field of metabolic engineering has delivered new microbial cell factories and processes for the production of different compounds including biofuels, (di)carboxylic acids, alcohols, and amino acids. Most of these processes are aerobic, with few exceptions (e.g., alcoholic fermentation), and attention is focused on assembling a high-flux product pathway with a production limit usually set by the oxygen transfer rate. By contrast, anaerobic product synthesis offers significant benefits compared to aerobic systems: higher yields, less heat generation, reduced biomass production, and lower mechanical energy input, which can significantly reduce production costs. Using simple thermodynamic calculations, we demonstrate that many products can theoretically be produced under anaerobic conditions using several conventional and non-conventional substrates. Nutzungsrecht: Copyright © 2015 Elsevier Ltd. All rights reserved. bioprocess design microbial cell factories Agricultural production Food Alternative energy sources Solvents Glucose Raw materials Costs Synthesis gas Factories Glycerol anaerobic product formation Aqueous solutions thermodynamics Ethanol van Maris, A J A oth Wahl, S Aljoscha oth Heijnen, J J oth Enthalten in Trends in biotechnology Cambridge : Elsevier, 1983 33(2015), 9, Seite 534-546 (DE-627)129140708 (DE-600)47474-5 (DE-576)014453339 0167-7799 nnns volume:33 year:2015 number:9 pages:534-546 http://dx.doi.org/10.1016/j.tibtech.2015.06.010 Volltext http://www.ncbi.nlm.nih.gov/pubmed/26232033 http://search.proquest.com/docview/1708154379 GBV_USEFLAG_A SYSFLAG_A GBV_OLC SSG-OLC-TEC SSG-OLC-CHE SSG-OLC-PHA SSG-OLC-DE-84 SSG-OPC-FOR GBV_ILN_70 GBV_ILN_252 GBV_ILN_2004 GBV_ILN_2016 GBV_ILN_2219 GBV_ILN_4029 58.30 AVZ AR 33 2015 9 534-546 |
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10.1016/j.tibtech.2015.06.010 doi PQ20160617 (DE-627)OLC195675413X (DE-599)GBVOLC195675413X (PRQ)c2163-eb7bf09a0d494b5f229d505ed07a939da1b1f4af107d432fcd035986b0ace90d0 (KEY)0131566820150000033000900534thermodynamicsbaseddesignofmicrobialcellfactoriesf DE-627 ger DE-627 rakwb eng 570 DNB 58.30 bkl Cueto-Rojas, Hugo F verfasserin aut Thermodynamics-based design of microbial cell factories for anaerobic product formation 2015 Text txt rdacontent ohne Hilfsmittel zu benutzen n rdamedia Band nc rdacarrier The field of metabolic engineering has delivered new microbial cell factories and processes for the production of different compounds including biofuels, (di)carboxylic acids, alcohols, and amino acids. Most of these processes are aerobic, with few exceptions (e.g., alcoholic fermentation), and attention is focused on assembling a high-flux product pathway with a production limit usually set by the oxygen transfer rate. By contrast, anaerobic product synthesis offers significant benefits compared to aerobic systems: higher yields, less heat generation, reduced biomass production, and lower mechanical energy input, which can significantly reduce production costs. Using simple thermodynamic calculations, we demonstrate that many products can theoretically be produced under anaerobic conditions using several conventional and non-conventional substrates. Nutzungsrecht: Copyright © 2015 Elsevier Ltd. All rights reserved. bioprocess design microbial cell factories Agricultural production Food Alternative energy sources Solvents Glucose Raw materials Costs Synthesis gas Factories Glycerol anaerobic product formation Aqueous solutions thermodynamics Ethanol van Maris, A J A oth Wahl, S Aljoscha oth Heijnen, J J oth Enthalten in Trends in biotechnology Cambridge : Elsevier, 1983 33(2015), 9, Seite 534-546 (DE-627)129140708 (DE-600)47474-5 (DE-576)014453339 0167-7799 nnns volume:33 year:2015 number:9 pages:534-546 http://dx.doi.org/10.1016/j.tibtech.2015.06.010 Volltext http://www.ncbi.nlm.nih.gov/pubmed/26232033 http://search.proquest.com/docview/1708154379 GBV_USEFLAG_A SYSFLAG_A GBV_OLC SSG-OLC-TEC SSG-OLC-CHE SSG-OLC-PHA SSG-OLC-DE-84 SSG-OPC-FOR GBV_ILN_70 GBV_ILN_252 GBV_ILN_2004 GBV_ILN_2016 GBV_ILN_2219 GBV_ILN_4029 58.30 AVZ AR 33 2015 9 534-546 |
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10.1016/j.tibtech.2015.06.010 doi PQ20160617 (DE-627)OLC195675413X (DE-599)GBVOLC195675413X (PRQ)c2163-eb7bf09a0d494b5f229d505ed07a939da1b1f4af107d432fcd035986b0ace90d0 (KEY)0131566820150000033000900534thermodynamicsbaseddesignofmicrobialcellfactoriesf DE-627 ger DE-627 rakwb eng 570 DNB 58.30 bkl Cueto-Rojas, Hugo F verfasserin aut Thermodynamics-based design of microbial cell factories for anaerobic product formation 2015 Text txt rdacontent ohne Hilfsmittel zu benutzen n rdamedia Band nc rdacarrier The field of metabolic engineering has delivered new microbial cell factories and processes for the production of different compounds including biofuels, (di)carboxylic acids, alcohols, and amino acids. Most of these processes are aerobic, with few exceptions (e.g., alcoholic fermentation), and attention is focused on assembling a high-flux product pathway with a production limit usually set by the oxygen transfer rate. By contrast, anaerobic product synthesis offers significant benefits compared to aerobic systems: higher yields, less heat generation, reduced biomass production, and lower mechanical energy input, which can significantly reduce production costs. Using simple thermodynamic calculations, we demonstrate that many products can theoretically be produced under anaerobic conditions using several conventional and non-conventional substrates. Nutzungsrecht: Copyright © 2015 Elsevier Ltd. All rights reserved. bioprocess design microbial cell factories Agricultural production Food Alternative energy sources Solvents Glucose Raw materials Costs Synthesis gas Factories Glycerol anaerobic product formation Aqueous solutions thermodynamics Ethanol van Maris, A J A oth Wahl, S Aljoscha oth Heijnen, J J oth Enthalten in Trends in biotechnology Cambridge : Elsevier, 1983 33(2015), 9, Seite 534-546 (DE-627)129140708 (DE-600)47474-5 (DE-576)014453339 0167-7799 nnns volume:33 year:2015 number:9 pages:534-546 http://dx.doi.org/10.1016/j.tibtech.2015.06.010 Volltext http://www.ncbi.nlm.nih.gov/pubmed/26232033 http://search.proquest.com/docview/1708154379 GBV_USEFLAG_A SYSFLAG_A GBV_OLC SSG-OLC-TEC SSG-OLC-CHE SSG-OLC-PHA SSG-OLC-DE-84 SSG-OPC-FOR GBV_ILN_70 GBV_ILN_252 GBV_ILN_2004 GBV_ILN_2016 GBV_ILN_2219 GBV_ILN_4029 58.30 AVZ AR 33 2015 9 534-546 |
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The field of metabolic engineering has delivered new microbial cell factories and processes for the production of different compounds including biofuels, (di)carboxylic acids, alcohols, and amino acids. Most of these processes are aerobic, with few exceptions (e.g., alcoholic fermentation), and attention is focused on assembling a high-flux product pathway with a production limit usually set by the oxygen transfer rate. By contrast, anaerobic product synthesis offers significant benefits compared to aerobic systems: higher yields, less heat generation, reduced biomass production, and lower mechanical energy input, which can significantly reduce production costs. Using simple thermodynamic calculations, we demonstrate that many products can theoretically be produced under anaerobic conditions using several conventional and non-conventional substrates. |
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The field of metabolic engineering has delivered new microbial cell factories and processes for the production of different compounds including biofuels, (di)carboxylic acids, alcohols, and amino acids. Most of these processes are aerobic, with few exceptions (e.g., alcoholic fermentation), and attention is focused on assembling a high-flux product pathway with a production limit usually set by the oxygen transfer rate. By contrast, anaerobic product synthesis offers significant benefits compared to aerobic systems: higher yields, less heat generation, reduced biomass production, and lower mechanical energy input, which can significantly reduce production costs. Using simple thermodynamic calculations, we demonstrate that many products can theoretically be produced under anaerobic conditions using several conventional and non-conventional substrates. |
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The field of metabolic engineering has delivered new microbial cell factories and processes for the production of different compounds including biofuels, (di)carboxylic acids, alcohols, and amino acids. Most of these processes are aerobic, with few exceptions (e.g., alcoholic fermentation), and attention is focused on assembling a high-flux product pathway with a production limit usually set by the oxygen transfer rate. By contrast, anaerobic product synthesis offers significant benefits compared to aerobic systems: higher yields, less heat generation, reduced biomass production, and lower mechanical energy input, which can significantly reduce production costs. Using simple thermodynamic calculations, we demonstrate that many products can theoretically be produced under anaerobic conditions using several conventional and non-conventional substrates. |
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Thermodynamics-based design of microbial cell factories for anaerobic product formation |
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http://dx.doi.org/10.1016/j.tibtech.2015.06.010 http://www.ncbi.nlm.nih.gov/pubmed/26232033 http://search.proquest.com/docview/1708154379 |
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