Efficient capturing of circulating tumor cells using a magnetic capture column and a size-selective filter
Detecting and analyzing circulating tumor cells (CTCs) in the blood of cancer patients is a promising approach for the early diagnosis of metastasis. Previously, we developed a size-selective filter for capturing CTCs, but its use was time consuming, particularly for capturing CTCs from large volume...
Ausführliche Beschreibung
Autor*in: |
Yamamoto, Shuhei [verfasserIn] |
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Format: |
Artikel |
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Sprache: |
Englisch |
Erschienen: |
2015 |
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Rechteinformationen: |
Nutzungsrecht: © Springer-Verlag Berlin Heidelberg 2015 |
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Schlagwörter: |
Environmental Engineering/Biotechnology Industrial Chemistry/Chemical Engineering |
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Übergeordnetes Werk: |
Enthalten in: Bioprocess and biosystems engineering - Berlin : Springer, 2001, 38(2015), 9, Seite 1693-1704 |
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Übergeordnetes Werk: |
volume:38 ; year:2015 ; number:9 ; pages:1693-1704 |
Links: |
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DOI / URN: |
10.1007/s00449-015-1412-9 |
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Katalog-ID: |
OLC1957364467 |
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520 | |a Detecting and analyzing circulating tumor cells (CTCs) in the blood of cancer patients is a promising approach for the early diagnosis of metastasis. Previously, we developed a size-selective filter for capturing CTCs, but its use was time consuming, particularly for capturing CTCs from large volumes of blood. In the present study, we describe the use of a magnetic capture column for rapid and efficient isolation of CTCs, which were magnetically labeled with magnetite cationic liposomes. In the capturing process, large volumes of blood containing magnetically labeled cancer cells were introduced into the column at a high flow rate to capture the cells, which were then added into the filter at a low flow rate. Our results show that the combined use of the column and filter decreased the required time for the spiked cancer cell capture, and the recovery rate of the spiked cancer cells from blood was significantly higher using the combination process (80.7 %) than that using the filter alone (64.7 %). Moreover, almost twice the number of CTCs could be captured from the blood of metastatic model mice using the combination process. These results suggest that the developed process would be useful for the rapid and efficient isolation of CTCs. | ||
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650 | 4 | |a Circulating tumor cell | |
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700 | 1 | |a Iwata, Hiroji |4 oth | |
700 | 1 | |a Nakanishi, Hayao |4 oth | |
700 | 1 | |a Honda, Hiroyuki |4 oth | |
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10.1007/s00449-015-1412-9 doi PQ20160617 (DE-627)OLC1957364467 (DE-599)GBVOLC1957364467 (PRQ)c3127-a24ca744358e57a557f6909c838e250191d427ac52335e722ab6df16d076c9980 (KEY)0150926820150000038000901693efficientcapturingofcirculatingtumorcellsusingamag DE-627 ger DE-627 rakwb eng 660 DNB 570 AVZ Yamamoto, Shuhei verfasserin aut Efficient capturing of circulating tumor cells using a magnetic capture column and a size-selective filter 2015 Text txt rdacontent ohne Hilfsmittel zu benutzen n rdamedia Band nc rdacarrier Detecting and analyzing circulating tumor cells (CTCs) in the blood of cancer patients is a promising approach for the early diagnosis of metastasis. Previously, we developed a size-selective filter for capturing CTCs, but its use was time consuming, particularly for capturing CTCs from large volumes of blood. In the present study, we describe the use of a magnetic capture column for rapid and efficient isolation of CTCs, which were magnetically labeled with magnetite cationic liposomes. In the capturing process, large volumes of blood containing magnetically labeled cancer cells were introduced into the column at a high flow rate to capture the cells, which were then added into the filter at a low flow rate. Our results show that the combined use of the column and filter decreased the required time for the spiked cancer cell capture, and the recovery rate of the spiked cancer cells from blood was significantly higher using the combination process (80.7 %) than that using the filter alone (64.7 %). Moreover, almost twice the number of CTCs could be captured from the blood of metastatic model mice using the combination process. These results suggest that the developed process would be useful for the rapid and efficient isolation of CTCs. Nutzungsrecht: © Springer-Verlag Berlin Heidelberg 2015 Environmental Engineering/Biotechnology Industrial Chemistry/Chemical Engineering Chemistry Circulating tumor cell Magnetic separation Nanoparticles Industrial and Production Engineering Cancer Biotechnology Food Science Blood Cell adhesion & migration Magnetism Bioengineering Fei, Jiahui oth Okochi, Mina oth Shimizu, Kazunori oth Yusa, Akiko oth Kondo, Naoto oth Iwata, Hiroji oth Nakanishi, Hayao oth Honda, Hiroyuki oth Enthalten in Bioprocess and biosystems engineering Berlin : Springer, 2001 38(2015), 9, Seite 1693-1704 (DE-627)333469763 (DE-600)2056063-1 (DE-576)094533709 1615-7591 nnns volume:38 year:2015 number:9 pages:1693-1704 http://dx.doi.org/10.1007/s00449-015-1412-9 Volltext http://www.ncbi.nlm.nih.gov/pubmed/25964183 http://search.proquest.com/docview/1703888876 GBV_USEFLAG_A SYSFLAG_A GBV_OLC SSG-OLC-UMW SSG-OLC-ARC SSG-OLC-TEC SSG-OLC-CHE SSG-OLC-PHA SSG-OLC-DE-84 GBV_ILN_24 GBV_ILN_31 GBV_ILN_70 GBV_ILN_2018 GBV_ILN_4046 GBV_ILN_4277 AR 38 2015 9 1693-1704 |
spelling |
10.1007/s00449-015-1412-9 doi PQ20160617 (DE-627)OLC1957364467 (DE-599)GBVOLC1957364467 (PRQ)c3127-a24ca744358e57a557f6909c838e250191d427ac52335e722ab6df16d076c9980 (KEY)0150926820150000038000901693efficientcapturingofcirculatingtumorcellsusingamag DE-627 ger DE-627 rakwb eng 660 DNB 570 AVZ Yamamoto, Shuhei verfasserin aut Efficient capturing of circulating tumor cells using a magnetic capture column and a size-selective filter 2015 Text txt rdacontent ohne Hilfsmittel zu benutzen n rdamedia Band nc rdacarrier Detecting and analyzing circulating tumor cells (CTCs) in the blood of cancer patients is a promising approach for the early diagnosis of metastasis. Previously, we developed a size-selective filter for capturing CTCs, but its use was time consuming, particularly for capturing CTCs from large volumes of blood. In the present study, we describe the use of a magnetic capture column for rapid and efficient isolation of CTCs, which were magnetically labeled with magnetite cationic liposomes. In the capturing process, large volumes of blood containing magnetically labeled cancer cells were introduced into the column at a high flow rate to capture the cells, which were then added into the filter at a low flow rate. Our results show that the combined use of the column and filter decreased the required time for the spiked cancer cell capture, and the recovery rate of the spiked cancer cells from blood was significantly higher using the combination process (80.7 %) than that using the filter alone (64.7 %). Moreover, almost twice the number of CTCs could be captured from the blood of metastatic model mice using the combination process. These results suggest that the developed process would be useful for the rapid and efficient isolation of CTCs. Nutzungsrecht: © Springer-Verlag Berlin Heidelberg 2015 Environmental Engineering/Biotechnology Industrial Chemistry/Chemical Engineering Chemistry Circulating tumor cell Magnetic separation Nanoparticles Industrial and Production Engineering Cancer Biotechnology Food Science Blood Cell adhesion & migration Magnetism Bioengineering Fei, Jiahui oth Okochi, Mina oth Shimizu, Kazunori oth Yusa, Akiko oth Kondo, Naoto oth Iwata, Hiroji oth Nakanishi, Hayao oth Honda, Hiroyuki oth Enthalten in Bioprocess and biosystems engineering Berlin : Springer, 2001 38(2015), 9, Seite 1693-1704 (DE-627)333469763 (DE-600)2056063-1 (DE-576)094533709 1615-7591 nnns volume:38 year:2015 number:9 pages:1693-1704 http://dx.doi.org/10.1007/s00449-015-1412-9 Volltext http://www.ncbi.nlm.nih.gov/pubmed/25964183 http://search.proquest.com/docview/1703888876 GBV_USEFLAG_A SYSFLAG_A GBV_OLC SSG-OLC-UMW SSG-OLC-ARC SSG-OLC-TEC SSG-OLC-CHE SSG-OLC-PHA SSG-OLC-DE-84 GBV_ILN_24 GBV_ILN_31 GBV_ILN_70 GBV_ILN_2018 GBV_ILN_4046 GBV_ILN_4277 AR 38 2015 9 1693-1704 |
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10.1007/s00449-015-1412-9 doi PQ20160617 (DE-627)OLC1957364467 (DE-599)GBVOLC1957364467 (PRQ)c3127-a24ca744358e57a557f6909c838e250191d427ac52335e722ab6df16d076c9980 (KEY)0150926820150000038000901693efficientcapturingofcirculatingtumorcellsusingamag DE-627 ger DE-627 rakwb eng 660 DNB 570 AVZ Yamamoto, Shuhei verfasserin aut Efficient capturing of circulating tumor cells using a magnetic capture column and a size-selective filter 2015 Text txt rdacontent ohne Hilfsmittel zu benutzen n rdamedia Band nc rdacarrier Detecting and analyzing circulating tumor cells (CTCs) in the blood of cancer patients is a promising approach for the early diagnosis of metastasis. Previously, we developed a size-selective filter for capturing CTCs, but its use was time consuming, particularly for capturing CTCs from large volumes of blood. In the present study, we describe the use of a magnetic capture column for rapid and efficient isolation of CTCs, which were magnetically labeled with magnetite cationic liposomes. In the capturing process, large volumes of blood containing magnetically labeled cancer cells were introduced into the column at a high flow rate to capture the cells, which were then added into the filter at a low flow rate. Our results show that the combined use of the column and filter decreased the required time for the spiked cancer cell capture, and the recovery rate of the spiked cancer cells from blood was significantly higher using the combination process (80.7 %) than that using the filter alone (64.7 %). Moreover, almost twice the number of CTCs could be captured from the blood of metastatic model mice using the combination process. These results suggest that the developed process would be useful for the rapid and efficient isolation of CTCs. Nutzungsrecht: © Springer-Verlag Berlin Heidelberg 2015 Environmental Engineering/Biotechnology Industrial Chemistry/Chemical Engineering Chemistry Circulating tumor cell Magnetic separation Nanoparticles Industrial and Production Engineering Cancer Biotechnology Food Science Blood Cell adhesion & migration Magnetism Bioengineering Fei, Jiahui oth Okochi, Mina oth Shimizu, Kazunori oth Yusa, Akiko oth Kondo, Naoto oth Iwata, Hiroji oth Nakanishi, Hayao oth Honda, Hiroyuki oth Enthalten in Bioprocess and biosystems engineering Berlin : Springer, 2001 38(2015), 9, Seite 1693-1704 (DE-627)333469763 (DE-600)2056063-1 (DE-576)094533709 1615-7591 nnns volume:38 year:2015 number:9 pages:1693-1704 http://dx.doi.org/10.1007/s00449-015-1412-9 Volltext http://www.ncbi.nlm.nih.gov/pubmed/25964183 http://search.proquest.com/docview/1703888876 GBV_USEFLAG_A SYSFLAG_A GBV_OLC SSG-OLC-UMW SSG-OLC-ARC SSG-OLC-TEC SSG-OLC-CHE SSG-OLC-PHA SSG-OLC-DE-84 GBV_ILN_24 GBV_ILN_31 GBV_ILN_70 GBV_ILN_2018 GBV_ILN_4046 GBV_ILN_4277 AR 38 2015 9 1693-1704 |
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10.1007/s00449-015-1412-9 doi PQ20160617 (DE-627)OLC1957364467 (DE-599)GBVOLC1957364467 (PRQ)c3127-a24ca744358e57a557f6909c838e250191d427ac52335e722ab6df16d076c9980 (KEY)0150926820150000038000901693efficientcapturingofcirculatingtumorcellsusingamag DE-627 ger DE-627 rakwb eng 660 DNB 570 AVZ Yamamoto, Shuhei verfasserin aut Efficient capturing of circulating tumor cells using a magnetic capture column and a size-selective filter 2015 Text txt rdacontent ohne Hilfsmittel zu benutzen n rdamedia Band nc rdacarrier Detecting and analyzing circulating tumor cells (CTCs) in the blood of cancer patients is a promising approach for the early diagnosis of metastasis. Previously, we developed a size-selective filter for capturing CTCs, but its use was time consuming, particularly for capturing CTCs from large volumes of blood. In the present study, we describe the use of a magnetic capture column for rapid and efficient isolation of CTCs, which were magnetically labeled with magnetite cationic liposomes. In the capturing process, large volumes of blood containing magnetically labeled cancer cells were introduced into the column at a high flow rate to capture the cells, which were then added into the filter at a low flow rate. Our results show that the combined use of the column and filter decreased the required time for the spiked cancer cell capture, and the recovery rate of the spiked cancer cells from blood was significantly higher using the combination process (80.7 %) than that using the filter alone (64.7 %). Moreover, almost twice the number of CTCs could be captured from the blood of metastatic model mice using the combination process. These results suggest that the developed process would be useful for the rapid and efficient isolation of CTCs. Nutzungsrecht: © Springer-Verlag Berlin Heidelberg 2015 Environmental Engineering/Biotechnology Industrial Chemistry/Chemical Engineering Chemistry Circulating tumor cell Magnetic separation Nanoparticles Industrial and Production Engineering Cancer Biotechnology Food Science Blood Cell adhesion & migration Magnetism Bioengineering Fei, Jiahui oth Okochi, Mina oth Shimizu, Kazunori oth Yusa, Akiko oth Kondo, Naoto oth Iwata, Hiroji oth Nakanishi, Hayao oth Honda, Hiroyuki oth Enthalten in Bioprocess and biosystems engineering Berlin : Springer, 2001 38(2015), 9, Seite 1693-1704 (DE-627)333469763 (DE-600)2056063-1 (DE-576)094533709 1615-7591 nnns volume:38 year:2015 number:9 pages:1693-1704 http://dx.doi.org/10.1007/s00449-015-1412-9 Volltext http://www.ncbi.nlm.nih.gov/pubmed/25964183 http://search.proquest.com/docview/1703888876 GBV_USEFLAG_A SYSFLAG_A GBV_OLC SSG-OLC-UMW SSG-OLC-ARC SSG-OLC-TEC SSG-OLC-CHE SSG-OLC-PHA SSG-OLC-DE-84 GBV_ILN_24 GBV_ILN_31 GBV_ILN_70 GBV_ILN_2018 GBV_ILN_4046 GBV_ILN_4277 AR 38 2015 9 1693-1704 |
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10.1007/s00449-015-1412-9 doi PQ20160617 (DE-627)OLC1957364467 (DE-599)GBVOLC1957364467 (PRQ)c3127-a24ca744358e57a557f6909c838e250191d427ac52335e722ab6df16d076c9980 (KEY)0150926820150000038000901693efficientcapturingofcirculatingtumorcellsusingamag DE-627 ger DE-627 rakwb eng 660 DNB 570 AVZ Yamamoto, Shuhei verfasserin aut Efficient capturing of circulating tumor cells using a magnetic capture column and a size-selective filter 2015 Text txt rdacontent ohne Hilfsmittel zu benutzen n rdamedia Band nc rdacarrier Detecting and analyzing circulating tumor cells (CTCs) in the blood of cancer patients is a promising approach for the early diagnosis of metastasis. Previously, we developed a size-selective filter for capturing CTCs, but its use was time consuming, particularly for capturing CTCs from large volumes of blood. In the present study, we describe the use of a magnetic capture column for rapid and efficient isolation of CTCs, which were magnetically labeled with magnetite cationic liposomes. In the capturing process, large volumes of blood containing magnetically labeled cancer cells were introduced into the column at a high flow rate to capture the cells, which were then added into the filter at a low flow rate. Our results show that the combined use of the column and filter decreased the required time for the spiked cancer cell capture, and the recovery rate of the spiked cancer cells from blood was significantly higher using the combination process (80.7 %) than that using the filter alone (64.7 %). Moreover, almost twice the number of CTCs could be captured from the blood of metastatic model mice using the combination process. These results suggest that the developed process would be useful for the rapid and efficient isolation of CTCs. Nutzungsrecht: © Springer-Verlag Berlin Heidelberg 2015 Environmental Engineering/Biotechnology Industrial Chemistry/Chemical Engineering Chemistry Circulating tumor cell Magnetic separation Nanoparticles Industrial and Production Engineering Cancer Biotechnology Food Science Blood Cell adhesion & migration Magnetism Bioengineering Fei, Jiahui oth Okochi, Mina oth Shimizu, Kazunori oth Yusa, Akiko oth Kondo, Naoto oth Iwata, Hiroji oth Nakanishi, Hayao oth Honda, Hiroyuki oth Enthalten in Bioprocess and biosystems engineering Berlin : Springer, 2001 38(2015), 9, Seite 1693-1704 (DE-627)333469763 (DE-600)2056063-1 (DE-576)094533709 1615-7591 nnns volume:38 year:2015 number:9 pages:1693-1704 http://dx.doi.org/10.1007/s00449-015-1412-9 Volltext http://www.ncbi.nlm.nih.gov/pubmed/25964183 http://search.proquest.com/docview/1703888876 GBV_USEFLAG_A SYSFLAG_A GBV_OLC SSG-OLC-UMW SSG-OLC-ARC SSG-OLC-TEC SSG-OLC-CHE SSG-OLC-PHA SSG-OLC-DE-84 GBV_ILN_24 GBV_ILN_31 GBV_ILN_70 GBV_ILN_2018 GBV_ILN_4046 GBV_ILN_4277 AR 38 2015 9 1693-1704 |
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efficient capturing of circulating tumor cells using a magnetic capture column and a size-selective filter |
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Efficient capturing of circulating tumor cells using a magnetic capture column and a size-selective filter |
abstract |
Detecting and analyzing circulating tumor cells (CTCs) in the blood of cancer patients is a promising approach for the early diagnosis of metastasis. Previously, we developed a size-selective filter for capturing CTCs, but its use was time consuming, particularly for capturing CTCs from large volumes of blood. In the present study, we describe the use of a magnetic capture column for rapid and efficient isolation of CTCs, which were magnetically labeled with magnetite cationic liposomes. In the capturing process, large volumes of blood containing magnetically labeled cancer cells were introduced into the column at a high flow rate to capture the cells, which were then added into the filter at a low flow rate. Our results show that the combined use of the column and filter decreased the required time for the spiked cancer cell capture, and the recovery rate of the spiked cancer cells from blood was significantly higher using the combination process (80.7 %) than that using the filter alone (64.7 %). Moreover, almost twice the number of CTCs could be captured from the blood of metastatic model mice using the combination process. These results suggest that the developed process would be useful for the rapid and efficient isolation of CTCs. |
abstractGer |
Detecting and analyzing circulating tumor cells (CTCs) in the blood of cancer patients is a promising approach for the early diagnosis of metastasis. Previously, we developed a size-selective filter for capturing CTCs, but its use was time consuming, particularly for capturing CTCs from large volumes of blood. In the present study, we describe the use of a magnetic capture column for rapid and efficient isolation of CTCs, which were magnetically labeled with magnetite cationic liposomes. In the capturing process, large volumes of blood containing magnetically labeled cancer cells were introduced into the column at a high flow rate to capture the cells, which were then added into the filter at a low flow rate. Our results show that the combined use of the column and filter decreased the required time for the spiked cancer cell capture, and the recovery rate of the spiked cancer cells from blood was significantly higher using the combination process (80.7 %) than that using the filter alone (64.7 %). Moreover, almost twice the number of CTCs could be captured from the blood of metastatic model mice using the combination process. These results suggest that the developed process would be useful for the rapid and efficient isolation of CTCs. |
abstract_unstemmed |
Detecting and analyzing circulating tumor cells (CTCs) in the blood of cancer patients is a promising approach for the early diagnosis of metastasis. Previously, we developed a size-selective filter for capturing CTCs, but its use was time consuming, particularly for capturing CTCs from large volumes of blood. In the present study, we describe the use of a magnetic capture column for rapid and efficient isolation of CTCs, which were magnetically labeled with magnetite cationic liposomes. In the capturing process, large volumes of blood containing magnetically labeled cancer cells were introduced into the column at a high flow rate to capture the cells, which were then added into the filter at a low flow rate. Our results show that the combined use of the column and filter decreased the required time for the spiked cancer cell capture, and the recovery rate of the spiked cancer cells from blood was significantly higher using the combination process (80.7 %) than that using the filter alone (64.7 %). Moreover, almost twice the number of CTCs could be captured from the blood of metastatic model mice using the combination process. These results suggest that the developed process would be useful for the rapid and efficient isolation of CTCs. |
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title_short |
Efficient capturing of circulating tumor cells using a magnetic capture column and a size-selective filter |
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http://dx.doi.org/10.1007/s00449-015-1412-9 http://www.ncbi.nlm.nih.gov/pubmed/25964183 http://search.proquest.com/docview/1703888876 |
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