In vitro evaluations of electrospun nanofiber scaffolds composed of poly(ɛ-caprolactone) and polyethylenimine

The work was intended to explore the effect of the widely available cationic polymer polyethylenimine (PEI) on small diameter poly([varepsilon]-caprolactone) (PCL) blood vessel grafts. PEI was blended with PCL and electrospun into nanofibrous vascular scaffolds. The morphologies, wettabilities, mech...
Ausführliche Beschreibung

Gespeichert in:

Autor*in:	Xin Jing [verfasserIn] Hao-Yang Mi Max R Salick Travis Cordie Jason McNulty Xiang-Fang Peng Lih-Sheng Turng

Format:	Artikel
Sprache:	Englisch

Erschienen:	2015

Schlagwörter:	Skin & tissue grafts vascular tissue engineering endothelial cells Nanomaterials Materials research Blood vessels Analysis electrospinning poly([...]-caprolactone) (PCL) polyethylenimine (PEI) Studies Polymers

Systematik:	VA 5350

Übergeordnetes Werk:	Enthalten in: Journal of materials research - Warrendale, Pa. : Materials Research Society, 1986, 30(2015), 11, Seite 1808-1819
Übergeordnetes Werk:	volume:30 ; year:2015 ; number:11 ; pages:1808-1819

Links:	Volltext Link aufrufen

DOI / URN:	10.1557/jmr.2015.117

Katalog-ID:	OLC195746044X

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520			\|a The work was intended to explore the effect of the widely available cationic polymer polyethylenimine (PEI) on small diameter poly([varepsilon]-caprolactone) (PCL) blood vessel grafts. PEI was blended with PCL and electrospun into nanofibrous vascular scaffolds. The morphologies, wettabilities, mechanical properties, and biological activities of the PCL/PEI electrospun nanofibers were investigated. It was found that by increasing the content of PEI to 5% within the scaffolds, the fiber diameters decreased from 469.7 ± 212.1 to 282.5 ± 107.1 nm, the water contact angle was reduced from 126.6 ± 1.1° to 27.6 ± 3.9°, while the Young's modulus increased from 2.0 ± 0.2 to 4.1 ± 0.1 MPa, the suture retention strength increased from 4.2 ± 0.4 to 6.1 ± 0.7 N, and the burst pressure increased from 801.2 ± 14.1 to 926.2 ± 22.8 mmHg. The in vitro evaluations demonstrated that the nanofibers containing 2% PEI promoted the attachment and proliferation of human umbilical vein endothelial cells (HUVECs).
650		4	\|a Skin & tissue grafts
650		4	\|a vascular tissue engineering
650		4	\|a endothelial cells
650		4	\|a Nanomaterials
650		4	\|a Materials research
650		4	\|a Blood vessels
650		4	\|a Analysis
650		4	\|a electrospinning
650		4	\|a poly([...]-caprolactone) (PCL)
650		4	\|a polyethylenimine (PEI)
650		4	\|a Studies
650		4	\|a Polymers
700	0		\|a Hao-Yang Mi \|4 oth
700	0		\|a Max R Salick \|4 oth
700	0		\|a Travis Cordie \|4 oth
700	0		\|a Jason McNulty \|4 oth
700	0		\|a Xiang-Fang Peng \|4 oth
700	0		\|a Lih-Sheng Turng \|4 oth
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allfields	10.1557/jmr.2015.117 doi PQ20160617 (DE-627)OLC195746044X (DE-599)GBVOLC195746044X (PRQ)c2491-8f709e480bafadec3f353a01716c6317c8676fbb4193bcd48e0f99c26b182e3d0 (KEY)0153552820150000030001101808invitroevaluationsofelectrospunnanofiberscaffoldsc DE-627 ger DE-627 rakwb eng 670 DNB VA 5350 AVZ rvk 51.00 bkl Xin Jing verfasserin aut In vitro evaluations of electrospun nanofiber scaffolds composed of poly(ɛ-caprolactone) and polyethylenimine 2015 Text txt rdacontent ohne Hilfsmittel zu benutzen n rdamedia Band nc rdacarrier The work was intended to explore the effect of the widely available cationic polymer polyethylenimine (PEI) on small diameter poly([varepsilon]-caprolactone) (PCL) blood vessel grafts. PEI was blended with PCL and electrospun into nanofibrous vascular scaffolds. The morphologies, wettabilities, mechanical properties, and biological activities of the PCL/PEI electrospun nanofibers were investigated. It was found that by increasing the content of PEI to 5% within the scaffolds, the fiber diameters decreased from 469.7 ± 212.1 to 282.5 ± 107.1 nm, the water contact angle was reduced from 126.6 ± 1.1° to 27.6 ± 3.9°, while the Young's modulus increased from 2.0 ± 0.2 to 4.1 ± 0.1 MPa, the suture retention strength increased from 4.2 ± 0.4 to 6.1 ± 0.7 N, and the burst pressure increased from 801.2 ± 14.1 to 926.2 ± 22.8 mmHg. The in vitro evaluations demonstrated that the nanofibers containing 2% PEI promoted the attachment and proliferation of human umbilical vein endothelial cells (HUVECs). Skin & tissue grafts vascular tissue engineering endothelial cells Nanomaterials Materials research Blood vessels Analysis electrospinning poly([...]-caprolactone) (PCL) polyethylenimine (PEI) Studies Polymers Hao-Yang Mi oth Max R Salick oth Travis Cordie oth Jason McNulty oth Xiang-Fang Peng oth Lih-Sheng Turng oth Enthalten in Journal of materials research Warrendale, Pa. : Materials Research Society, 1986 30(2015), 11, Seite 1808-1819 (DE-627)129206288 (DE-600)54876-5 (DE-576)01445744X 0884-2914 nnns volume:30 year:2015 number:11 pages:1808-1819 http://dx.doi.org/10.1557/jmr.2015.117 Volltext http://search.proquest.com/docview/1699473315 GBV_USEFLAG_A SYSFLAG_A GBV_OLC SSG-OLC-TEC GBV_ILN_21 GBV_ILN_24 GBV_ILN_31 GBV_ILN_70 GBV_ILN_2005 GBV_ILN_2020 GBV_ILN_4126 GBV_ILN_4319 GBV_ILN_4323 VA 5350 51.00 AVZ AR 30 2015 11 1808-1819
spelling	10.1557/jmr.2015.117 doi PQ20160617 (DE-627)OLC195746044X (DE-599)GBVOLC195746044X (PRQ)c2491-8f709e480bafadec3f353a01716c6317c8676fbb4193bcd48e0f99c26b182e3d0 (KEY)0153552820150000030001101808invitroevaluationsofelectrospunnanofiberscaffoldsc DE-627 ger DE-627 rakwb eng 670 DNB VA 5350 AVZ rvk 51.00 bkl Xin Jing verfasserin aut In vitro evaluations of electrospun nanofiber scaffolds composed of poly(ɛ-caprolactone) and polyethylenimine 2015 Text txt rdacontent ohne Hilfsmittel zu benutzen n rdamedia Band nc rdacarrier The work was intended to explore the effect of the widely available cationic polymer polyethylenimine (PEI) on small diameter poly([varepsilon]-caprolactone) (PCL) blood vessel grafts. PEI was blended with PCL and electrospun into nanofibrous vascular scaffolds. The morphologies, wettabilities, mechanical properties, and biological activities of the PCL/PEI electrospun nanofibers were investigated. It was found that by increasing the content of PEI to 5% within the scaffolds, the fiber diameters decreased from 469.7 ± 212.1 to 282.5 ± 107.1 nm, the water contact angle was reduced from 126.6 ± 1.1° to 27.6 ± 3.9°, while the Young's modulus increased from 2.0 ± 0.2 to 4.1 ± 0.1 MPa, the suture retention strength increased from 4.2 ± 0.4 to 6.1 ± 0.7 N, and the burst pressure increased from 801.2 ± 14.1 to 926.2 ± 22.8 mmHg. The in vitro evaluations demonstrated that the nanofibers containing 2% PEI promoted the attachment and proliferation of human umbilical vein endothelial cells (HUVECs). Skin & tissue grafts vascular tissue engineering endothelial cells Nanomaterials Materials research Blood vessels Analysis electrospinning poly([...]-caprolactone) (PCL) polyethylenimine (PEI) Studies Polymers Hao-Yang Mi oth Max R Salick oth Travis Cordie oth Jason McNulty oth Xiang-Fang Peng oth Lih-Sheng Turng oth Enthalten in Journal of materials research Warrendale, Pa. : Materials Research Society, 1986 30(2015), 11, Seite 1808-1819 (DE-627)129206288 (DE-600)54876-5 (DE-576)01445744X 0884-2914 nnns volume:30 year:2015 number:11 pages:1808-1819 http://dx.doi.org/10.1557/jmr.2015.117 Volltext http://search.proquest.com/docview/1699473315 GBV_USEFLAG_A SYSFLAG_A GBV_OLC SSG-OLC-TEC GBV_ILN_21 GBV_ILN_24 GBV_ILN_31 GBV_ILN_70 GBV_ILN_2005 GBV_ILN_2020 GBV_ILN_4126 GBV_ILN_4319 GBV_ILN_4323 VA 5350 51.00 AVZ AR 30 2015 11 1808-1819
allfields_unstemmed	10.1557/jmr.2015.117 doi PQ20160617 (DE-627)OLC195746044X (DE-599)GBVOLC195746044X (PRQ)c2491-8f709e480bafadec3f353a01716c6317c8676fbb4193bcd48e0f99c26b182e3d0 (KEY)0153552820150000030001101808invitroevaluationsofelectrospunnanofiberscaffoldsc DE-627 ger DE-627 rakwb eng 670 DNB VA 5350 AVZ rvk 51.00 bkl Xin Jing verfasserin aut In vitro evaluations of electrospun nanofiber scaffolds composed of poly(ɛ-caprolactone) and polyethylenimine 2015 Text txt rdacontent ohne Hilfsmittel zu benutzen n rdamedia Band nc rdacarrier The work was intended to explore the effect of the widely available cationic polymer polyethylenimine (PEI) on small diameter poly([varepsilon]-caprolactone) (PCL) blood vessel grafts. PEI was blended with PCL and electrospun into nanofibrous vascular scaffolds. The morphologies, wettabilities, mechanical properties, and biological activities of the PCL/PEI electrospun nanofibers were investigated. It was found that by increasing the content of PEI to 5% within the scaffolds, the fiber diameters decreased from 469.7 ± 212.1 to 282.5 ± 107.1 nm, the water contact angle was reduced from 126.6 ± 1.1° to 27.6 ± 3.9°, while the Young's modulus increased from 2.0 ± 0.2 to 4.1 ± 0.1 MPa, the suture retention strength increased from 4.2 ± 0.4 to 6.1 ± 0.7 N, and the burst pressure increased from 801.2 ± 14.1 to 926.2 ± 22.8 mmHg. The in vitro evaluations demonstrated that the nanofibers containing 2% PEI promoted the attachment and proliferation of human umbilical vein endothelial cells (HUVECs). Skin & tissue grafts vascular tissue engineering endothelial cells Nanomaterials Materials research Blood vessels Analysis electrospinning poly([...]-caprolactone) (PCL) polyethylenimine (PEI) Studies Polymers Hao-Yang Mi oth Max R Salick oth Travis Cordie oth Jason McNulty oth Xiang-Fang Peng oth Lih-Sheng Turng oth Enthalten in Journal of materials research Warrendale, Pa. : Materials Research Society, 1986 30(2015), 11, Seite 1808-1819 (DE-627)129206288 (DE-600)54876-5 (DE-576)01445744X 0884-2914 nnns volume:30 year:2015 number:11 pages:1808-1819 http://dx.doi.org/10.1557/jmr.2015.117 Volltext http://search.proquest.com/docview/1699473315 GBV_USEFLAG_A SYSFLAG_A GBV_OLC SSG-OLC-TEC GBV_ILN_21 GBV_ILN_24 GBV_ILN_31 GBV_ILN_70 GBV_ILN_2005 GBV_ILN_2020 GBV_ILN_4126 GBV_ILN_4319 GBV_ILN_4323 VA 5350 51.00 AVZ AR 30 2015 11 1808-1819
allfieldsGer	10.1557/jmr.2015.117 doi PQ20160617 (DE-627)OLC195746044X (DE-599)GBVOLC195746044X (PRQ)c2491-8f709e480bafadec3f353a01716c6317c8676fbb4193bcd48e0f99c26b182e3d0 (KEY)0153552820150000030001101808invitroevaluationsofelectrospunnanofiberscaffoldsc DE-627 ger DE-627 rakwb eng 670 DNB VA 5350 AVZ rvk 51.00 bkl Xin Jing verfasserin aut In vitro evaluations of electrospun nanofiber scaffolds composed of poly(ɛ-caprolactone) and polyethylenimine 2015 Text txt rdacontent ohne Hilfsmittel zu benutzen n rdamedia Band nc rdacarrier The work was intended to explore the effect of the widely available cationic polymer polyethylenimine (PEI) on small diameter poly([varepsilon]-caprolactone) (PCL) blood vessel grafts. PEI was blended with PCL and electrospun into nanofibrous vascular scaffolds. The morphologies, wettabilities, mechanical properties, and biological activities of the PCL/PEI electrospun nanofibers were investigated. It was found that by increasing the content of PEI to 5% within the scaffolds, the fiber diameters decreased from 469.7 ± 212.1 to 282.5 ± 107.1 nm, the water contact angle was reduced from 126.6 ± 1.1° to 27.6 ± 3.9°, while the Young's modulus increased from 2.0 ± 0.2 to 4.1 ± 0.1 MPa, the suture retention strength increased from 4.2 ± 0.4 to 6.1 ± 0.7 N, and the burst pressure increased from 801.2 ± 14.1 to 926.2 ± 22.8 mmHg. The in vitro evaluations demonstrated that the nanofibers containing 2% PEI promoted the attachment and proliferation of human umbilical vein endothelial cells (HUVECs). Skin & tissue grafts vascular tissue engineering endothelial cells Nanomaterials Materials research Blood vessels Analysis electrospinning poly([...]-caprolactone) (PCL) polyethylenimine (PEI) Studies Polymers Hao-Yang Mi oth Max R Salick oth Travis Cordie oth Jason McNulty oth Xiang-Fang Peng oth Lih-Sheng Turng oth Enthalten in Journal of materials research Warrendale, Pa. : Materials Research Society, 1986 30(2015), 11, Seite 1808-1819 (DE-627)129206288 (DE-600)54876-5 (DE-576)01445744X 0884-2914 nnns volume:30 year:2015 number:11 pages:1808-1819 http://dx.doi.org/10.1557/jmr.2015.117 Volltext http://search.proquest.com/docview/1699473315 GBV_USEFLAG_A SYSFLAG_A GBV_OLC SSG-OLC-TEC GBV_ILN_21 GBV_ILN_24 GBV_ILN_31 GBV_ILN_70 GBV_ILN_2005 GBV_ILN_2020 GBV_ILN_4126 GBV_ILN_4319 GBV_ILN_4323 VA 5350 51.00 AVZ AR 30 2015 11 1808-1819
allfieldsSound	10.1557/jmr.2015.117 doi PQ20160617 (DE-627)OLC195746044X (DE-599)GBVOLC195746044X (PRQ)c2491-8f709e480bafadec3f353a01716c6317c8676fbb4193bcd48e0f99c26b182e3d0 (KEY)0153552820150000030001101808invitroevaluationsofelectrospunnanofiberscaffoldsc DE-627 ger DE-627 rakwb eng 670 DNB VA 5350 AVZ rvk 51.00 bkl Xin Jing verfasserin aut In vitro evaluations of electrospun nanofiber scaffolds composed of poly(ɛ-caprolactone) and polyethylenimine 2015 Text txt rdacontent ohne Hilfsmittel zu benutzen n rdamedia Band nc rdacarrier The work was intended to explore the effect of the widely available cationic polymer polyethylenimine (PEI) on small diameter poly([varepsilon]-caprolactone) (PCL) blood vessel grafts. PEI was blended with PCL and electrospun into nanofibrous vascular scaffolds. The morphologies, wettabilities, mechanical properties, and biological activities of the PCL/PEI electrospun nanofibers were investigated. It was found that by increasing the content of PEI to 5% within the scaffolds, the fiber diameters decreased from 469.7 ± 212.1 to 282.5 ± 107.1 nm, the water contact angle was reduced from 126.6 ± 1.1° to 27.6 ± 3.9°, while the Young's modulus increased from 2.0 ± 0.2 to 4.1 ± 0.1 MPa, the suture retention strength increased from 4.2 ± 0.4 to 6.1 ± 0.7 N, and the burst pressure increased from 801.2 ± 14.1 to 926.2 ± 22.8 mmHg. The in vitro evaluations demonstrated that the nanofibers containing 2% PEI promoted the attachment and proliferation of human umbilical vein endothelial cells (HUVECs). Skin & tissue grafts vascular tissue engineering endothelial cells Nanomaterials Materials research Blood vessels Analysis electrospinning poly([...]-caprolactone) (PCL) polyethylenimine (PEI) Studies Polymers Hao-Yang Mi oth Max R Salick oth Travis Cordie oth Jason McNulty oth Xiang-Fang Peng oth Lih-Sheng Turng oth Enthalten in Journal of materials research Warrendale, Pa. : Materials Research Society, 1986 30(2015), 11, Seite 1808-1819 (DE-627)129206288 (DE-600)54876-5 (DE-576)01445744X 0884-2914 nnns volume:30 year:2015 number:11 pages:1808-1819 http://dx.doi.org/10.1557/jmr.2015.117 Volltext http://search.proquest.com/docview/1699473315 GBV_USEFLAG_A SYSFLAG_A GBV_OLC SSG-OLC-TEC GBV_ILN_21 GBV_ILN_24 GBV_ILN_31 GBV_ILN_70 GBV_ILN_2005 GBV_ILN_2020 GBV_ILN_4126 GBV_ILN_4319 GBV_ILN_4323 VA 5350 51.00 AVZ AR 30 2015 11 1808-1819
language	English
source	Enthalten in Journal of materials research 30(2015), 11, Seite 1808-1819 volume:30 year:2015 number:11 pages:1808-1819
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topic_facet	Skin & tissue grafts vascular tissue engineering endothelial cells Nanomaterials Materials research Blood vessels Analysis electrospinning poly([...]-caprolactone) (PCL) polyethylenimine (PEI) Studies Polymers
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author	Xin Jing
spellingShingle	Xin Jing ddc 670 rvk VA 5350 bkl 51.00 misc Skin & tissue grafts misc vascular tissue engineering misc endothelial cells misc Nanomaterials misc Materials research misc Blood vessels misc Analysis misc electrospinning misc poly([...]-caprolactone) (PCL) misc polyethylenimine (PEI) misc Studies misc Polymers In vitro evaluations of electrospun nanofiber scaffolds composed of poly(ɛ-caprolactone) and polyethylenimine
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topic_title	670 DNB VA 5350 AVZ rvk 51.00 bkl In vitro evaluations of electrospun nanofiber scaffolds composed of poly(ɛ-caprolactone) and polyethylenimine Skin & tissue grafts vascular tissue engineering endothelial cells Nanomaterials Materials research Blood vessels Analysis electrospinning poly([...]-caprolactone) (PCL) polyethylenimine (PEI) Studies Polymers
topic	ddc 670 rvk VA 5350 bkl 51.00 misc Skin & tissue grafts misc vascular tissue engineering misc endothelial cells misc Nanomaterials misc Materials research misc Blood vessels misc Analysis misc electrospinning misc poly([...]-caprolactone) (PCL) misc polyethylenimine (PEI) misc Studies misc Polymers
topic_unstemmed	ddc 670 rvk VA 5350 bkl 51.00 misc Skin & tissue grafts misc vascular tissue engineering misc endothelial cells misc Nanomaterials misc Materials research misc Blood vessels misc Analysis misc electrospinning misc poly([...]-caprolactone) (PCL) misc polyethylenimine (PEI) misc Studies misc Polymers
topic_browse	ddc 670 rvk VA 5350 bkl 51.00 misc Skin & tissue grafts misc vascular tissue engineering misc endothelial cells misc Nanomaterials misc Materials research misc Blood vessels misc Analysis misc electrospinning misc poly([...]-caprolactone) (PCL) misc polyethylenimine (PEI) misc Studies misc Polymers
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title	In vitro evaluations of electrospun nanofiber scaffolds composed of poly(ɛ-caprolactone) and polyethylenimine
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title_full	In vitro evaluations of electrospun nanofiber scaffolds composed of poly(ɛ-caprolactone) and polyethylenimine
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title_sort	in vitro evaluations of electrospun nanofiber scaffolds composed of poly(ɛ-caprolactone) and polyethylenimine
title_auth	In vitro evaluations of electrospun nanofiber scaffolds composed of poly(ɛ-caprolactone) and polyethylenimine
abstract	The work was intended to explore the effect of the widely available cationic polymer polyethylenimine (PEI) on small diameter poly([varepsilon]-caprolactone) (PCL) blood vessel grafts. PEI was blended with PCL and electrospun into nanofibrous vascular scaffolds. The morphologies, wettabilities, mechanical properties, and biological activities of the PCL/PEI electrospun nanofibers were investigated. It was found that by increasing the content of PEI to 5% within the scaffolds, the fiber diameters decreased from 469.7 ± 212.1 to 282.5 ± 107.1 nm, the water contact angle was reduced from 126.6 ± 1.1° to 27.6 ± 3.9°, while the Young's modulus increased from 2.0 ± 0.2 to 4.1 ± 0.1 MPa, the suture retention strength increased from 4.2 ± 0.4 to 6.1 ± 0.7 N, and the burst pressure increased from 801.2 ± 14.1 to 926.2 ± 22.8 mmHg. The in vitro evaluations demonstrated that the nanofibers containing 2% PEI promoted the attachment and proliferation of human umbilical vein endothelial cells (HUVECs).
abstractGer	The work was intended to explore the effect of the widely available cationic polymer polyethylenimine (PEI) on small diameter poly([varepsilon]-caprolactone) (PCL) blood vessel grafts. PEI was blended with PCL and electrospun into nanofibrous vascular scaffolds. The morphologies, wettabilities, mechanical properties, and biological activities of the PCL/PEI electrospun nanofibers were investigated. It was found that by increasing the content of PEI to 5% within the scaffolds, the fiber diameters decreased from 469.7 ± 212.1 to 282.5 ± 107.1 nm, the water contact angle was reduced from 126.6 ± 1.1° to 27.6 ± 3.9°, while the Young's modulus increased from 2.0 ± 0.2 to 4.1 ± 0.1 MPa, the suture retention strength increased from 4.2 ± 0.4 to 6.1 ± 0.7 N, and the burst pressure increased from 801.2 ± 14.1 to 926.2 ± 22.8 mmHg. The in vitro evaluations demonstrated that the nanofibers containing 2% PEI promoted the attachment and proliferation of human umbilical vein endothelial cells (HUVECs).
abstract_unstemmed	The work was intended to explore the effect of the widely available cationic polymer polyethylenimine (PEI) on small diameter poly([varepsilon]-caprolactone) (PCL) blood vessel grafts. PEI was blended with PCL and electrospun into nanofibrous vascular scaffolds. The morphologies, wettabilities, mechanical properties, and biological activities of the PCL/PEI electrospun nanofibers were investigated. It was found that by increasing the content of PEI to 5% within the scaffolds, the fiber diameters decreased from 469.7 ± 212.1 to 282.5 ± 107.1 nm, the water contact angle was reduced from 126.6 ± 1.1° to 27.6 ± 3.9°, while the Young's modulus increased from 2.0 ± 0.2 to 4.1 ± 0.1 MPa, the suture retention strength increased from 4.2 ± 0.4 to 6.1 ± 0.7 N, and the burst pressure increased from 801.2 ± 14.1 to 926.2 ± 22.8 mmHg. The in vitro evaluations demonstrated that the nanofibers containing 2% PEI promoted the attachment and proliferation of human umbilical vein endothelial cells (HUVECs).
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container_issue	11
title_short	In vitro evaluations of electrospun nanofiber scaffolds composed of poly(ɛ-caprolactone) and polyethylenimine
url	http://dx.doi.org/10.1557/jmr.2015.117 http://search.proquest.com/docview/1699473315
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author2	Hao-Yang Mi Max R Salick Travis Cordie Jason McNulty Xiang-Fang Peng Lih-Sheng Turng
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In vitro evaluations of electrospun nanofiber scaffolds composed of poly(ɛ-caprolactone) and polyethylenimine

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