Amelioration of carbon tetrachloride-induced pulmonary toxicity with Oxalis corniculata
This research work was planned to investigate the antioxidant potential of methanolic crude extract of Oxalis corniculata (OCME) against lung injuries initiated by carbon tetrachloride (CCl4) in rats at histological and biochemical level. A total of 42 female Sprague Dawley rats were randomly distri...
Ausführliche Beschreibung
Autor*in: |
Ahmad, Bushra [verfasserIn] |
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Format: |
Artikel |
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Sprache: |
Englisch |
Erschienen: |
2015 |
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Rechteinformationen: |
Nutzungsrecht: © The Author(s) 2013. |
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Übergeordnetes Werk: |
Enthalten in: Toxicology and industrial health - London : Sage, 1985, 31(2015), 12, Seite 1243-1251 |
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Übergeordnetes Werk: |
volume:31 ; year:2015 ; number:12 ; pages:1243-1251 |
Links: |
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DOI / URN: |
10.1177/0748233713487245 |
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Katalog-ID: |
OLC1957473541 |
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10.1177/0748233713487245 doi PQ20160430 (DE-627)OLC1957473541 (DE-599)GBVOLC1957473541 (PRQ)c1532-3a328ddc7abe4f99a3cb7bc78a808d3a51e354fd946da654c3af9d1cc5c379aa0 (KEY)0153972820150000031001201243ameliorationofcarbontetrachlorideinducedpulmonaryt DE-627 ger DE-627 rakwb eng 570 ZDB Ahmad, Bushra verfasserin aut Amelioration of carbon tetrachloride-induced pulmonary toxicity with Oxalis corniculata 2015 Text txt rdacontent ohne Hilfsmittel zu benutzen n rdamedia Band nc rdacarrier This research work was planned to investigate the antioxidant potential of methanolic crude extract of Oxalis corniculata (OCME) against lung injuries initiated by carbon tetrachloride (CCl4) in rats at histological and biochemical level. A total of 42 female Sprague Dawley rats were randomly distributed in to seven groups and each group comprised of six rats. Experiment was completed in 22 days (10 doses at alternate days). Group I was not treated (control rats), while group II was administered with vehicles (olive oil and dimethyl sulfoxide), groups III, IV, and V were treated with 1 ml kg(-1) body weight (b.w.) of CCl4 (20% in olive oil). Group III received only CCl4, whereas groups IV and V were administered with 100 and 200 mg kg(-1) b.w. of OCME, respectively. Group VI was administered with OCME (200 mg kg(-1) b.w.) alone. Group VII was treated with sylimarin (50 mg kg(-1) b.w.). CCl4 enhanced the lipid peroxidation while reduced the glutathione in lung samples. Activities of antioxidant enzymes, catalase, peroxidase, superoxide dismutase, and glutathione-S-transferase decreased in lung homogenates with CCl4. Treatment of CCl4 induced deleterious changes in the microanatomy of lungs by rupturing the alveolar septa, thickening of alveolar walls, and damaging the cells with subsequent collapse of blood vessels due to the accumulation of degenerated blood cells. OCME, dose dependently, prevented the alterations in these parameters. These results suggest that OCME protected the lungs due to its intrinsic properties by scavenging of free radicals generated by CCl4. Nutzungsrecht: © The Author(s) 2013. Khan, Muhammad Rashid oth Shah, Naseer Ali oth Enthalten in Toxicology and industrial health London : Sage, 1985 31(2015), 12, Seite 1243-1251 (DE-627)129224871 (DE-600)56831-4 (DE-576)912922487X 0748-2337 nnns volume:31 year:2015 number:12 pages:1243-1251 http://dx.doi.org/10.1177/0748233713487245 Volltext http://www.ncbi.nlm.nih.gov/pubmed/23796759 GBV_USEFLAG_A SYSFLAG_A GBV_OLC SSG-OLC-UMW SSG-OLC-ARC SSG-OLC-TEC SSG-OLC-PHA SSG-OLC-DE-84 GBV_ILN_70 GBV_ILN_4012 GBV_ILN_4219 AR 31 2015 12 1243-1251 |
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10.1177/0748233713487245 doi PQ20160430 (DE-627)OLC1957473541 (DE-599)GBVOLC1957473541 (PRQ)c1532-3a328ddc7abe4f99a3cb7bc78a808d3a51e354fd946da654c3af9d1cc5c379aa0 (KEY)0153972820150000031001201243ameliorationofcarbontetrachlorideinducedpulmonaryt DE-627 ger DE-627 rakwb eng 570 ZDB Ahmad, Bushra verfasserin aut Amelioration of carbon tetrachloride-induced pulmonary toxicity with Oxalis corniculata 2015 Text txt rdacontent ohne Hilfsmittel zu benutzen n rdamedia Band nc rdacarrier This research work was planned to investigate the antioxidant potential of methanolic crude extract of Oxalis corniculata (OCME) against lung injuries initiated by carbon tetrachloride (CCl4) in rats at histological and biochemical level. A total of 42 female Sprague Dawley rats were randomly distributed in to seven groups and each group comprised of six rats. Experiment was completed in 22 days (10 doses at alternate days). Group I was not treated (control rats), while group II was administered with vehicles (olive oil and dimethyl sulfoxide), groups III, IV, and V were treated with 1 ml kg(-1) body weight (b.w.) of CCl4 (20% in olive oil). Group III received only CCl4, whereas groups IV and V were administered with 100 and 200 mg kg(-1) b.w. of OCME, respectively. Group VI was administered with OCME (200 mg kg(-1) b.w.) alone. Group VII was treated with sylimarin (50 mg kg(-1) b.w.). CCl4 enhanced the lipid peroxidation while reduced the glutathione in lung samples. Activities of antioxidant enzymes, catalase, peroxidase, superoxide dismutase, and glutathione-S-transferase decreased in lung homogenates with CCl4. Treatment of CCl4 induced deleterious changes in the microanatomy of lungs by rupturing the alveolar septa, thickening of alveolar walls, and damaging the cells with subsequent collapse of blood vessels due to the accumulation of degenerated blood cells. OCME, dose dependently, prevented the alterations in these parameters. These results suggest that OCME protected the lungs due to its intrinsic properties by scavenging of free radicals generated by CCl4. Nutzungsrecht: © The Author(s) 2013. Khan, Muhammad Rashid oth Shah, Naseer Ali oth Enthalten in Toxicology and industrial health London : Sage, 1985 31(2015), 12, Seite 1243-1251 (DE-627)129224871 (DE-600)56831-4 (DE-576)912922487X 0748-2337 nnns volume:31 year:2015 number:12 pages:1243-1251 http://dx.doi.org/10.1177/0748233713487245 Volltext http://www.ncbi.nlm.nih.gov/pubmed/23796759 GBV_USEFLAG_A SYSFLAG_A GBV_OLC SSG-OLC-UMW SSG-OLC-ARC SSG-OLC-TEC SSG-OLC-PHA SSG-OLC-DE-84 GBV_ILN_70 GBV_ILN_4012 GBV_ILN_4219 AR 31 2015 12 1243-1251 |
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10.1177/0748233713487245 doi PQ20160430 (DE-627)OLC1957473541 (DE-599)GBVOLC1957473541 (PRQ)c1532-3a328ddc7abe4f99a3cb7bc78a808d3a51e354fd946da654c3af9d1cc5c379aa0 (KEY)0153972820150000031001201243ameliorationofcarbontetrachlorideinducedpulmonaryt DE-627 ger DE-627 rakwb eng 570 ZDB Ahmad, Bushra verfasserin aut Amelioration of carbon tetrachloride-induced pulmonary toxicity with Oxalis corniculata 2015 Text txt rdacontent ohne Hilfsmittel zu benutzen n rdamedia Band nc rdacarrier This research work was planned to investigate the antioxidant potential of methanolic crude extract of Oxalis corniculata (OCME) against lung injuries initiated by carbon tetrachloride (CCl4) in rats at histological and biochemical level. A total of 42 female Sprague Dawley rats were randomly distributed in to seven groups and each group comprised of six rats. Experiment was completed in 22 days (10 doses at alternate days). Group I was not treated (control rats), while group II was administered with vehicles (olive oil and dimethyl sulfoxide), groups III, IV, and V were treated with 1 ml kg(-1) body weight (b.w.) of CCl4 (20% in olive oil). Group III received only CCl4, whereas groups IV and V were administered with 100 and 200 mg kg(-1) b.w. of OCME, respectively. Group VI was administered with OCME (200 mg kg(-1) b.w.) alone. Group VII was treated with sylimarin (50 mg kg(-1) b.w.). CCl4 enhanced the lipid peroxidation while reduced the glutathione in lung samples. Activities of antioxidant enzymes, catalase, peroxidase, superoxide dismutase, and glutathione-S-transferase decreased in lung homogenates with CCl4. Treatment of CCl4 induced deleterious changes in the microanatomy of lungs by rupturing the alveolar septa, thickening of alveolar walls, and damaging the cells with subsequent collapse of blood vessels due to the accumulation of degenerated blood cells. OCME, dose dependently, prevented the alterations in these parameters. These results suggest that OCME protected the lungs due to its intrinsic properties by scavenging of free radicals generated by CCl4. Nutzungsrecht: © The Author(s) 2013. Khan, Muhammad Rashid oth Shah, Naseer Ali oth Enthalten in Toxicology and industrial health London : Sage, 1985 31(2015), 12, Seite 1243-1251 (DE-627)129224871 (DE-600)56831-4 (DE-576)912922487X 0748-2337 nnns volume:31 year:2015 number:12 pages:1243-1251 http://dx.doi.org/10.1177/0748233713487245 Volltext http://www.ncbi.nlm.nih.gov/pubmed/23796759 GBV_USEFLAG_A SYSFLAG_A GBV_OLC SSG-OLC-UMW SSG-OLC-ARC SSG-OLC-TEC SSG-OLC-PHA SSG-OLC-DE-84 GBV_ILN_70 GBV_ILN_4012 GBV_ILN_4219 AR 31 2015 12 1243-1251 |
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10.1177/0748233713487245 doi PQ20160430 (DE-627)OLC1957473541 (DE-599)GBVOLC1957473541 (PRQ)c1532-3a328ddc7abe4f99a3cb7bc78a808d3a51e354fd946da654c3af9d1cc5c379aa0 (KEY)0153972820150000031001201243ameliorationofcarbontetrachlorideinducedpulmonaryt DE-627 ger DE-627 rakwb eng 570 ZDB Ahmad, Bushra verfasserin aut Amelioration of carbon tetrachloride-induced pulmonary toxicity with Oxalis corniculata 2015 Text txt rdacontent ohne Hilfsmittel zu benutzen n rdamedia Band nc rdacarrier This research work was planned to investigate the antioxidant potential of methanolic crude extract of Oxalis corniculata (OCME) against lung injuries initiated by carbon tetrachloride (CCl4) in rats at histological and biochemical level. A total of 42 female Sprague Dawley rats were randomly distributed in to seven groups and each group comprised of six rats. Experiment was completed in 22 days (10 doses at alternate days). Group I was not treated (control rats), while group II was administered with vehicles (olive oil and dimethyl sulfoxide), groups III, IV, and V were treated with 1 ml kg(-1) body weight (b.w.) of CCl4 (20% in olive oil). Group III received only CCl4, whereas groups IV and V were administered with 100 and 200 mg kg(-1) b.w. of OCME, respectively. Group VI was administered with OCME (200 mg kg(-1) b.w.) alone. Group VII was treated with sylimarin (50 mg kg(-1) b.w.). CCl4 enhanced the lipid peroxidation while reduced the glutathione in lung samples. Activities of antioxidant enzymes, catalase, peroxidase, superoxide dismutase, and glutathione-S-transferase decreased in lung homogenates with CCl4. Treatment of CCl4 induced deleterious changes in the microanatomy of lungs by rupturing the alveolar septa, thickening of alveolar walls, and damaging the cells with subsequent collapse of blood vessels due to the accumulation of degenerated blood cells. OCME, dose dependently, prevented the alterations in these parameters. These results suggest that OCME protected the lungs due to its intrinsic properties by scavenging of free radicals generated by CCl4. Nutzungsrecht: © The Author(s) 2013. Khan, Muhammad Rashid oth Shah, Naseer Ali oth Enthalten in Toxicology and industrial health London : Sage, 1985 31(2015), 12, Seite 1243-1251 (DE-627)129224871 (DE-600)56831-4 (DE-576)912922487X 0748-2337 nnns volume:31 year:2015 number:12 pages:1243-1251 http://dx.doi.org/10.1177/0748233713487245 Volltext http://www.ncbi.nlm.nih.gov/pubmed/23796759 GBV_USEFLAG_A SYSFLAG_A GBV_OLC SSG-OLC-UMW SSG-OLC-ARC SSG-OLC-TEC SSG-OLC-PHA SSG-OLC-DE-84 GBV_ILN_70 GBV_ILN_4012 GBV_ILN_4219 AR 31 2015 12 1243-1251 |
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author |
Ahmad, Bushra |
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Ahmad, Bushra ddc 570 Amelioration of carbon tetrachloride-induced pulmonary toxicity with Oxalis corniculata |
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Amelioration of carbon tetrachloride-induced pulmonary toxicity with Oxalis corniculata |
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Amelioration of carbon tetrachloride-induced pulmonary toxicity with Oxalis corniculata |
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amelioration of carbon tetrachloride-induced pulmonary toxicity with oxalis corniculata |
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Amelioration of carbon tetrachloride-induced pulmonary toxicity with Oxalis corniculata |
abstract |
This research work was planned to investigate the antioxidant potential of methanolic crude extract of Oxalis corniculata (OCME) against lung injuries initiated by carbon tetrachloride (CCl4) in rats at histological and biochemical level. A total of 42 female Sprague Dawley rats were randomly distributed in to seven groups and each group comprised of six rats. Experiment was completed in 22 days (10 doses at alternate days). Group I was not treated (control rats), while group II was administered with vehicles (olive oil and dimethyl sulfoxide), groups III, IV, and V were treated with 1 ml kg(-1) body weight (b.w.) of CCl4 (20% in olive oil). Group III received only CCl4, whereas groups IV and V were administered with 100 and 200 mg kg(-1) b.w. of OCME, respectively. Group VI was administered with OCME (200 mg kg(-1) b.w.) alone. Group VII was treated with sylimarin (50 mg kg(-1) b.w.). CCl4 enhanced the lipid peroxidation while reduced the glutathione in lung samples. Activities of antioxidant enzymes, catalase, peroxidase, superoxide dismutase, and glutathione-S-transferase decreased in lung homogenates with CCl4. Treatment of CCl4 induced deleterious changes in the microanatomy of lungs by rupturing the alveolar septa, thickening of alveolar walls, and damaging the cells with subsequent collapse of blood vessels due to the accumulation of degenerated blood cells. OCME, dose dependently, prevented the alterations in these parameters. These results suggest that OCME protected the lungs due to its intrinsic properties by scavenging of free radicals generated by CCl4. |
abstractGer |
This research work was planned to investigate the antioxidant potential of methanolic crude extract of Oxalis corniculata (OCME) against lung injuries initiated by carbon tetrachloride (CCl4) in rats at histological and biochemical level. A total of 42 female Sprague Dawley rats were randomly distributed in to seven groups and each group comprised of six rats. Experiment was completed in 22 days (10 doses at alternate days). Group I was not treated (control rats), while group II was administered with vehicles (olive oil and dimethyl sulfoxide), groups III, IV, and V were treated with 1 ml kg(-1) body weight (b.w.) of CCl4 (20% in olive oil). Group III received only CCl4, whereas groups IV and V were administered with 100 and 200 mg kg(-1) b.w. of OCME, respectively. Group VI was administered with OCME (200 mg kg(-1) b.w.) alone. Group VII was treated with sylimarin (50 mg kg(-1) b.w.). CCl4 enhanced the lipid peroxidation while reduced the glutathione in lung samples. Activities of antioxidant enzymes, catalase, peroxidase, superoxide dismutase, and glutathione-S-transferase decreased in lung homogenates with CCl4. Treatment of CCl4 induced deleterious changes in the microanatomy of lungs by rupturing the alveolar septa, thickening of alveolar walls, and damaging the cells with subsequent collapse of blood vessels due to the accumulation of degenerated blood cells. OCME, dose dependently, prevented the alterations in these parameters. These results suggest that OCME protected the lungs due to its intrinsic properties by scavenging of free radicals generated by CCl4. |
abstract_unstemmed |
This research work was planned to investigate the antioxidant potential of methanolic crude extract of Oxalis corniculata (OCME) against lung injuries initiated by carbon tetrachloride (CCl4) in rats at histological and biochemical level. A total of 42 female Sprague Dawley rats were randomly distributed in to seven groups and each group comprised of six rats. Experiment was completed in 22 days (10 doses at alternate days). Group I was not treated (control rats), while group II was administered with vehicles (olive oil and dimethyl sulfoxide), groups III, IV, and V were treated with 1 ml kg(-1) body weight (b.w.) of CCl4 (20% in olive oil). Group III received only CCl4, whereas groups IV and V were administered with 100 and 200 mg kg(-1) b.w. of OCME, respectively. Group VI was administered with OCME (200 mg kg(-1) b.w.) alone. Group VII was treated with sylimarin (50 mg kg(-1) b.w.). CCl4 enhanced the lipid peroxidation while reduced the glutathione in lung samples. Activities of antioxidant enzymes, catalase, peroxidase, superoxide dismutase, and glutathione-S-transferase decreased in lung homogenates with CCl4. Treatment of CCl4 induced deleterious changes in the microanatomy of lungs by rupturing the alveolar septa, thickening of alveolar walls, and damaging the cells with subsequent collapse of blood vessels due to the accumulation of degenerated blood cells. OCME, dose dependently, prevented the alterations in these parameters. These results suggest that OCME protected the lungs due to its intrinsic properties by scavenging of free radicals generated by CCl4. |
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title_short |
Amelioration of carbon tetrachloride-induced pulmonary toxicity with Oxalis corniculata |
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http://dx.doi.org/10.1177/0748233713487245 http://www.ncbi.nlm.nih.gov/pubmed/23796759 |
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Khan, Muhammad Rashid Shah, Naseer Ali |
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