The crude extract of Corni Fructus inhibits the migration and invasion of U‐2 OS human osteosarcoma cells through the inhibition of matrix metalloproteinase‐2/‐9 by MAPK signaling
Osteosarcoma is the most common primary malignancy of the bone cancers. In the Chinese population, the crude extract of Corni Fructus (CECF) has been used as Traditional Chinese medicine to treat several different diseases for hundreds of years. In the present study, effects of CECF on inhibition of...
Ausführliche Beschreibung
Gespeichert in:
| Autor*in: |
Liao, Ching‐Lung [verfasserIn] |
|---|
| Format: |
Artikel |
|---|---|
| Sprache: |
Englisch |
| Erschienen: |
2015 |
|---|
| Rechteinformationen: |
Nutzungsrecht: © 2013 Wiley Periodicals, Inc. |
|---|
| Übergeordnetes Werk: |
Enthalten in: Environmental toxicology - New York, NY : Wiley, 1999, 30(2015), 1, Seite 53-63 |
|---|---|
| Übergeordnetes Werk: |
volume:30 ; year:2015 ; number:1 ; pages:53-63 |
| Links: |
|---|
| DOI / URN: |
10.1002/tox.21894 |
|---|
| Katalog-ID: |
OLC1957481323 |
|---|
| LEADER | 01000caa a2200265 4500 | ||
|---|---|---|---|
| 001 | OLC1957481323 | ||
| 003 | DE-627 | ||
| 005 | 20230518141419.0 | ||
| 007 | tu | ||
| 008 | 160206s2015 xx ||||| 00| ||eng c | ||
| 024 | 7 | |a 10.1002/tox.21894 |2 doi | |
| 028 | 5 | 2 | |a PQ20160617 |
| 035 | |a (DE-627)OLC1957481323 | ||
| 035 | |a (DE-599)GBVOLC1957481323 | ||
| 035 | |a (PRQ)p3041-f0c7e53c0c43a35c8c629bd98f02b3a7a81b043495246de54d6f16a6c652118a3 | ||
| 035 | |a (KEY)0154138220150000030000100053crudeextractofcornifructusinhibitsthemigrationandi | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rakwb | ||
| 041 | |a eng | ||
| 082 | 0 | 4 | |a 690 |q ZDB |
| 084 | |a 43.00 |2 bkl | ||
| 100 | 1 | |a Liao, Ching‐Lung |e verfasserin |4 aut | |
| 245 | 1 | 4 | |a The crude extract of Corni Fructus inhibits the migration and invasion of U‐2 OS human osteosarcoma cells through the inhibition of matrix metalloproteinase‐2/‐9 by MAPK signaling |
| 264 | 1 | |c 2015 | |
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a ohne Hilfsmittel zu benutzen |b n |2 rdamedia | ||
| 338 | |a Band |b nc |2 rdacarrier | ||
| 520 | |a Osteosarcoma is the most common primary malignancy of the bone cancers. In the Chinese population, the crude extract of Corni Fructus (CECF) has been used as Traditional Chinese medicine to treat several different diseases for hundreds of years. In the present study, effects of CECF on inhibition of migration and invasion in U‐2 OS human osteosarcoma cells were examined. CECF significantly inhibited migration and invasion of U‐2 OS human osteosarcoma cells. We also found that CECF inhibited activities of matrix metalloproteinases‐2 (MMP‐2) and matrix metalloproteinases‐9 (MMP‐9). CECF decreased protein levels of FAK, PKC, SOS1, MKK7, MEKK3, GRB2, NF‐κB p65, COX‐2, HIF‐1α, PI3K, Rho A, ROCK‐1, IRE‐1α, p‐JNK1/2, p‐ERK1/2, p‐p38, Ras, p‐PERK, MMP‐2, MMP‐9, and VEGF in U‐2 OS cells. Results of this study indicate that CECF may have potential as a novel anticancer agent for the treatment of osteosarcoma by inhibiting migration and invasion of cancer cells © 2013 Wiley Periodicals, Inc. Environ Toxicol 30: 53–63, 2015. | ||
| 540 | |a Nutzungsrecht: © 2013 Wiley Periodicals, Inc. | ||
| 650 | 4 | |a Corni Fructus | |
| 650 | 4 | |a U‐2 OS human osteosarcoma cells | |
| 650 | 4 | |a invasion | |
| 650 | 4 | |a migration | |
| 650 | 4 | |a CECF | |
| 650 | 4 | |a crude extract of | |
| 650 | 4 | |a Matrix Metalloproteinase Inhibitors - isolation & purification | |
| 650 | 4 | |a Drugs, Chinese Herbal - isolation & purification | |
| 650 | 4 | |a Matrix Metalloproteinase 2 - metabolism | |
| 650 | 4 | |a Matrix Metalloproteinase 9 - metabolism | |
| 650 | 4 | |a Drugs, Chinese Herbal - pharmacology | |
| 650 | 4 | |a Cell Survival - drug effects | |
| 650 | 4 | |a Osteosarcoma - pathology | |
| 650 | 4 | |a Antineoplastic Agents, Phytogenic - isolation & purification | |
| 650 | 4 | |a Cornus - chemistry | |
| 650 | 4 | |a MAP Kinase Signaling System - drug effects | |
| 650 | 4 | |a Bone Neoplasms - pathology | |
| 650 | 4 | |a Cell Movement - drug effects | |
| 650 | 4 | |a NF-kappa B - metabolism | |
| 650 | 4 | |a Antineoplastic Agents, Phytogenic - pharmacology | |
| 650 | 4 | |a Matrix Metalloproteinase Inhibitors - pharmacology | |
| 700 | 1 | |a Lin, Ju‐Hwa |4 oth | |
| 700 | 1 | |a Lien, Jin‐Cherng |4 oth | |
| 700 | 1 | |a Hsu, Shu‐Chun |4 oth | |
| 700 | 1 | |a Chueh, Fu‐Shin |4 oth | |
| 700 | 1 | |a Yu, Chien‐Chih |4 oth | |
| 700 | 1 | |a Wu, Ping‐Ping |4 oth | |
| 700 | 1 | |a Huang, Yi‐Ping |4 oth | |
| 700 | 1 | |a Lin, Jaung‐Geng |4 oth | |
| 700 | 1 | |a Chung, Jing‐Gung |4 oth | |
| 773 | 0 | 8 | |i Enthalten in |t Environmental toxicology |d New York, NY : Wiley, 1999 |g 30(2015), 1, Seite 53-63 |w (DE-627)254912214 |w (DE-600)1463449-1 |w (DE-576)079598412 |x 1520-4081 |7 nnns |
| 773 | 1 | 8 | |g volume:30 |g year:2015 |g number:1 |g pages:53-63 |
| 856 | 4 | 1 | |u http://dx.doi.org/10.1002/tox.21894 |3 Volltext |
| 856 | 4 | 2 | |u http://onlinelibrary.wiley.com/doi/10.1002/tox.21894/abstract |
| 856 | 4 | 2 | |u http://www.ncbi.nlm.nih.gov/pubmed/23955962 |
| 856 | 4 | 2 | |u http://search.proquest.com/docview/1639601262 |
| 912 | |a GBV_USEFLAG_A | ||
| 912 | |a SYSFLAG_A | ||
| 912 | |a GBV_OLC | ||
| 912 | |a SSG-OLC-UMW | ||
| 912 | |a SSG-OLC-ARC | ||
| 912 | |a SSG-OLC-PHA | ||
| 912 | |a SSG-OLC-DE-84 | ||
| 912 | |a GBV_ILN_70 | ||
| 912 | |a GBV_ILN_4012 | ||
| 912 | |a GBV_ILN_4219 | ||
| 936 | b | k | |a 43.00 |q AVZ |
| 951 | |a AR | ||
| 952 | |d 30 |j 2015 |e 1 |h 53-63 | ||
| author_variant |
c l cl |
|---|---|
| matchkey_str |
article:15204081:2015----::hcuexrcocrircuihbtteirtoadnainf2suaotoacmclshogteniiinf |
| hierarchy_sort_str |
2015 |
| bklnumber |
43.00 |
| publishDate |
2015 |
| allfields |
10.1002/tox.21894 doi PQ20160617 (DE-627)OLC1957481323 (DE-599)GBVOLC1957481323 (PRQ)p3041-f0c7e53c0c43a35c8c629bd98f02b3a7a81b043495246de54d6f16a6c652118a3 (KEY)0154138220150000030000100053crudeextractofcornifructusinhibitsthemigrationandi DE-627 ger DE-627 rakwb eng 690 ZDB 43.00 bkl Liao, Ching‐Lung verfasserin aut The crude extract of Corni Fructus inhibits the migration and invasion of U‐2 OS human osteosarcoma cells through the inhibition of matrix metalloproteinase‐2/‐9 by MAPK signaling 2015 Text txt rdacontent ohne Hilfsmittel zu benutzen n rdamedia Band nc rdacarrier Osteosarcoma is the most common primary malignancy of the bone cancers. In the Chinese population, the crude extract of Corni Fructus (CECF) has been used as Traditional Chinese medicine to treat several different diseases for hundreds of years. In the present study, effects of CECF on inhibition of migration and invasion in U‐2 OS human osteosarcoma cells were examined. CECF significantly inhibited migration and invasion of U‐2 OS human osteosarcoma cells. We also found that CECF inhibited activities of matrix metalloproteinases‐2 (MMP‐2) and matrix metalloproteinases‐9 (MMP‐9). CECF decreased protein levels of FAK, PKC, SOS1, MKK7, MEKK3, GRB2, NF‐κB p65, COX‐2, HIF‐1α, PI3K, Rho A, ROCK‐1, IRE‐1α, p‐JNK1/2, p‐ERK1/2, p‐p38, Ras, p‐PERK, MMP‐2, MMP‐9, and VEGF in U‐2 OS cells. Results of this study indicate that CECF may have potential as a novel anticancer agent for the treatment of osteosarcoma by inhibiting migration and invasion of cancer cells © 2013 Wiley Periodicals, Inc. Environ Toxicol 30: 53–63, 2015. Nutzungsrecht: © 2013 Wiley Periodicals, Inc. Corni Fructus U‐2 OS human osteosarcoma cells invasion migration CECF crude extract of Matrix Metalloproteinase Inhibitors - isolation & purification Drugs, Chinese Herbal - isolation & purification Matrix Metalloproteinase 2 - metabolism Matrix Metalloproteinase 9 - metabolism Drugs, Chinese Herbal - pharmacology Cell Survival - drug effects Osteosarcoma - pathology Antineoplastic Agents, Phytogenic - isolation & purification Cornus - chemistry MAP Kinase Signaling System - drug effects Bone Neoplasms - pathology Cell Movement - drug effects NF-kappa B - metabolism Antineoplastic Agents, Phytogenic - pharmacology Matrix Metalloproteinase Inhibitors - pharmacology Lin, Ju‐Hwa oth Lien, Jin‐Cherng oth Hsu, Shu‐Chun oth Chueh, Fu‐Shin oth Yu, Chien‐Chih oth Wu, Ping‐Ping oth Huang, Yi‐Ping oth Lin, Jaung‐Geng oth Chung, Jing‐Gung oth Enthalten in Environmental toxicology New York, NY : Wiley, 1999 30(2015), 1, Seite 53-63 (DE-627)254912214 (DE-600)1463449-1 (DE-576)079598412 1520-4081 nnns volume:30 year:2015 number:1 pages:53-63 http://dx.doi.org/10.1002/tox.21894 Volltext http://onlinelibrary.wiley.com/doi/10.1002/tox.21894/abstract http://www.ncbi.nlm.nih.gov/pubmed/23955962 http://search.proquest.com/docview/1639601262 GBV_USEFLAG_A SYSFLAG_A GBV_OLC SSG-OLC-UMW SSG-OLC-ARC SSG-OLC-PHA SSG-OLC-DE-84 GBV_ILN_70 GBV_ILN_4012 GBV_ILN_4219 43.00 AVZ AR 30 2015 1 53-63 |
| spelling |
10.1002/tox.21894 doi PQ20160617 (DE-627)OLC1957481323 (DE-599)GBVOLC1957481323 (PRQ)p3041-f0c7e53c0c43a35c8c629bd98f02b3a7a81b043495246de54d6f16a6c652118a3 (KEY)0154138220150000030000100053crudeextractofcornifructusinhibitsthemigrationandi DE-627 ger DE-627 rakwb eng 690 ZDB 43.00 bkl Liao, Ching‐Lung verfasserin aut The crude extract of Corni Fructus inhibits the migration and invasion of U‐2 OS human osteosarcoma cells through the inhibition of matrix metalloproteinase‐2/‐9 by MAPK signaling 2015 Text txt rdacontent ohne Hilfsmittel zu benutzen n rdamedia Band nc rdacarrier Osteosarcoma is the most common primary malignancy of the bone cancers. In the Chinese population, the crude extract of Corni Fructus (CECF) has been used as Traditional Chinese medicine to treat several different diseases for hundreds of years. In the present study, effects of CECF on inhibition of migration and invasion in U‐2 OS human osteosarcoma cells were examined. CECF significantly inhibited migration and invasion of U‐2 OS human osteosarcoma cells. We also found that CECF inhibited activities of matrix metalloproteinases‐2 (MMP‐2) and matrix metalloproteinases‐9 (MMP‐9). CECF decreased protein levels of FAK, PKC, SOS1, MKK7, MEKK3, GRB2, NF‐κB p65, COX‐2, HIF‐1α, PI3K, Rho A, ROCK‐1, IRE‐1α, p‐JNK1/2, p‐ERK1/2, p‐p38, Ras, p‐PERK, MMP‐2, MMP‐9, and VEGF in U‐2 OS cells. Results of this study indicate that CECF may have potential as a novel anticancer agent for the treatment of osteosarcoma by inhibiting migration and invasion of cancer cells © 2013 Wiley Periodicals, Inc. Environ Toxicol 30: 53–63, 2015. Nutzungsrecht: © 2013 Wiley Periodicals, Inc. Corni Fructus U‐2 OS human osteosarcoma cells invasion migration CECF crude extract of Matrix Metalloproteinase Inhibitors - isolation & purification Drugs, Chinese Herbal - isolation & purification Matrix Metalloproteinase 2 - metabolism Matrix Metalloproteinase 9 - metabolism Drugs, Chinese Herbal - pharmacology Cell Survival - drug effects Osteosarcoma - pathology Antineoplastic Agents, Phytogenic - isolation & purification Cornus - chemistry MAP Kinase Signaling System - drug effects Bone Neoplasms - pathology Cell Movement - drug effects NF-kappa B - metabolism Antineoplastic Agents, Phytogenic - pharmacology Matrix Metalloproteinase Inhibitors - pharmacology Lin, Ju‐Hwa oth Lien, Jin‐Cherng oth Hsu, Shu‐Chun oth Chueh, Fu‐Shin oth Yu, Chien‐Chih oth Wu, Ping‐Ping oth Huang, Yi‐Ping oth Lin, Jaung‐Geng oth Chung, Jing‐Gung oth Enthalten in Environmental toxicology New York, NY : Wiley, 1999 30(2015), 1, Seite 53-63 (DE-627)254912214 (DE-600)1463449-1 (DE-576)079598412 1520-4081 nnns volume:30 year:2015 number:1 pages:53-63 http://dx.doi.org/10.1002/tox.21894 Volltext http://onlinelibrary.wiley.com/doi/10.1002/tox.21894/abstract http://www.ncbi.nlm.nih.gov/pubmed/23955962 http://search.proquest.com/docview/1639601262 GBV_USEFLAG_A SYSFLAG_A GBV_OLC SSG-OLC-UMW SSG-OLC-ARC SSG-OLC-PHA SSG-OLC-DE-84 GBV_ILN_70 GBV_ILN_4012 GBV_ILN_4219 43.00 AVZ AR 30 2015 1 53-63 |
| allfields_unstemmed |
10.1002/tox.21894 doi PQ20160617 (DE-627)OLC1957481323 (DE-599)GBVOLC1957481323 (PRQ)p3041-f0c7e53c0c43a35c8c629bd98f02b3a7a81b043495246de54d6f16a6c652118a3 (KEY)0154138220150000030000100053crudeextractofcornifructusinhibitsthemigrationandi DE-627 ger DE-627 rakwb eng 690 ZDB 43.00 bkl Liao, Ching‐Lung verfasserin aut The crude extract of Corni Fructus inhibits the migration and invasion of U‐2 OS human osteosarcoma cells through the inhibition of matrix metalloproteinase‐2/‐9 by MAPK signaling 2015 Text txt rdacontent ohne Hilfsmittel zu benutzen n rdamedia Band nc rdacarrier Osteosarcoma is the most common primary malignancy of the bone cancers. In the Chinese population, the crude extract of Corni Fructus (CECF) has been used as Traditional Chinese medicine to treat several different diseases for hundreds of years. In the present study, effects of CECF on inhibition of migration and invasion in U‐2 OS human osteosarcoma cells were examined. CECF significantly inhibited migration and invasion of U‐2 OS human osteosarcoma cells. We also found that CECF inhibited activities of matrix metalloproteinases‐2 (MMP‐2) and matrix metalloproteinases‐9 (MMP‐9). CECF decreased protein levels of FAK, PKC, SOS1, MKK7, MEKK3, GRB2, NF‐κB p65, COX‐2, HIF‐1α, PI3K, Rho A, ROCK‐1, IRE‐1α, p‐JNK1/2, p‐ERK1/2, p‐p38, Ras, p‐PERK, MMP‐2, MMP‐9, and VEGF in U‐2 OS cells. Results of this study indicate that CECF may have potential as a novel anticancer agent for the treatment of osteosarcoma by inhibiting migration and invasion of cancer cells © 2013 Wiley Periodicals, Inc. Environ Toxicol 30: 53–63, 2015. Nutzungsrecht: © 2013 Wiley Periodicals, Inc. Corni Fructus U‐2 OS human osteosarcoma cells invasion migration CECF crude extract of Matrix Metalloproteinase Inhibitors - isolation & purification Drugs, Chinese Herbal - isolation & purification Matrix Metalloproteinase 2 - metabolism Matrix Metalloproteinase 9 - metabolism Drugs, Chinese Herbal - pharmacology Cell Survival - drug effects Osteosarcoma - pathology Antineoplastic Agents, Phytogenic - isolation & purification Cornus - chemistry MAP Kinase Signaling System - drug effects Bone Neoplasms - pathology Cell Movement - drug effects NF-kappa B - metabolism Antineoplastic Agents, Phytogenic - pharmacology Matrix Metalloproteinase Inhibitors - pharmacology Lin, Ju‐Hwa oth Lien, Jin‐Cherng oth Hsu, Shu‐Chun oth Chueh, Fu‐Shin oth Yu, Chien‐Chih oth Wu, Ping‐Ping oth Huang, Yi‐Ping oth Lin, Jaung‐Geng oth Chung, Jing‐Gung oth Enthalten in Environmental toxicology New York, NY : Wiley, 1999 30(2015), 1, Seite 53-63 (DE-627)254912214 (DE-600)1463449-1 (DE-576)079598412 1520-4081 nnns volume:30 year:2015 number:1 pages:53-63 http://dx.doi.org/10.1002/tox.21894 Volltext http://onlinelibrary.wiley.com/doi/10.1002/tox.21894/abstract http://www.ncbi.nlm.nih.gov/pubmed/23955962 http://search.proquest.com/docview/1639601262 GBV_USEFLAG_A SYSFLAG_A GBV_OLC SSG-OLC-UMW SSG-OLC-ARC SSG-OLC-PHA SSG-OLC-DE-84 GBV_ILN_70 GBV_ILN_4012 GBV_ILN_4219 43.00 AVZ AR 30 2015 1 53-63 |
| allfieldsGer |
10.1002/tox.21894 doi PQ20160617 (DE-627)OLC1957481323 (DE-599)GBVOLC1957481323 (PRQ)p3041-f0c7e53c0c43a35c8c629bd98f02b3a7a81b043495246de54d6f16a6c652118a3 (KEY)0154138220150000030000100053crudeextractofcornifructusinhibitsthemigrationandi DE-627 ger DE-627 rakwb eng 690 ZDB 43.00 bkl Liao, Ching‐Lung verfasserin aut The crude extract of Corni Fructus inhibits the migration and invasion of U‐2 OS human osteosarcoma cells through the inhibition of matrix metalloproteinase‐2/‐9 by MAPK signaling 2015 Text txt rdacontent ohne Hilfsmittel zu benutzen n rdamedia Band nc rdacarrier Osteosarcoma is the most common primary malignancy of the bone cancers. In the Chinese population, the crude extract of Corni Fructus (CECF) has been used as Traditional Chinese medicine to treat several different diseases for hundreds of years. In the present study, effects of CECF on inhibition of migration and invasion in U‐2 OS human osteosarcoma cells were examined. CECF significantly inhibited migration and invasion of U‐2 OS human osteosarcoma cells. We also found that CECF inhibited activities of matrix metalloproteinases‐2 (MMP‐2) and matrix metalloproteinases‐9 (MMP‐9). CECF decreased protein levels of FAK, PKC, SOS1, MKK7, MEKK3, GRB2, NF‐κB p65, COX‐2, HIF‐1α, PI3K, Rho A, ROCK‐1, IRE‐1α, p‐JNK1/2, p‐ERK1/2, p‐p38, Ras, p‐PERK, MMP‐2, MMP‐9, and VEGF in U‐2 OS cells. Results of this study indicate that CECF may have potential as a novel anticancer agent for the treatment of osteosarcoma by inhibiting migration and invasion of cancer cells © 2013 Wiley Periodicals, Inc. Environ Toxicol 30: 53–63, 2015. Nutzungsrecht: © 2013 Wiley Periodicals, Inc. Corni Fructus U‐2 OS human osteosarcoma cells invasion migration CECF crude extract of Matrix Metalloproteinase Inhibitors - isolation & purification Drugs, Chinese Herbal - isolation & purification Matrix Metalloproteinase 2 - metabolism Matrix Metalloproteinase 9 - metabolism Drugs, Chinese Herbal - pharmacology Cell Survival - drug effects Osteosarcoma - pathology Antineoplastic Agents, Phytogenic - isolation & purification Cornus - chemistry MAP Kinase Signaling System - drug effects Bone Neoplasms - pathology Cell Movement - drug effects NF-kappa B - metabolism Antineoplastic Agents, Phytogenic - pharmacology Matrix Metalloproteinase Inhibitors - pharmacology Lin, Ju‐Hwa oth Lien, Jin‐Cherng oth Hsu, Shu‐Chun oth Chueh, Fu‐Shin oth Yu, Chien‐Chih oth Wu, Ping‐Ping oth Huang, Yi‐Ping oth Lin, Jaung‐Geng oth Chung, Jing‐Gung oth Enthalten in Environmental toxicology New York, NY : Wiley, 1999 30(2015), 1, Seite 53-63 (DE-627)254912214 (DE-600)1463449-1 (DE-576)079598412 1520-4081 nnns volume:30 year:2015 number:1 pages:53-63 http://dx.doi.org/10.1002/tox.21894 Volltext http://onlinelibrary.wiley.com/doi/10.1002/tox.21894/abstract http://www.ncbi.nlm.nih.gov/pubmed/23955962 http://search.proquest.com/docview/1639601262 GBV_USEFLAG_A SYSFLAG_A GBV_OLC SSG-OLC-UMW SSG-OLC-ARC SSG-OLC-PHA SSG-OLC-DE-84 GBV_ILN_70 GBV_ILN_4012 GBV_ILN_4219 43.00 AVZ AR 30 2015 1 53-63 |
| allfieldsSound |
10.1002/tox.21894 doi PQ20160617 (DE-627)OLC1957481323 (DE-599)GBVOLC1957481323 (PRQ)p3041-f0c7e53c0c43a35c8c629bd98f02b3a7a81b043495246de54d6f16a6c652118a3 (KEY)0154138220150000030000100053crudeextractofcornifructusinhibitsthemigrationandi DE-627 ger DE-627 rakwb eng 690 ZDB 43.00 bkl Liao, Ching‐Lung verfasserin aut The crude extract of Corni Fructus inhibits the migration and invasion of U‐2 OS human osteosarcoma cells through the inhibition of matrix metalloproteinase‐2/‐9 by MAPK signaling 2015 Text txt rdacontent ohne Hilfsmittel zu benutzen n rdamedia Band nc rdacarrier Osteosarcoma is the most common primary malignancy of the bone cancers. In the Chinese population, the crude extract of Corni Fructus (CECF) has been used as Traditional Chinese medicine to treat several different diseases for hundreds of years. In the present study, effects of CECF on inhibition of migration and invasion in U‐2 OS human osteosarcoma cells were examined. CECF significantly inhibited migration and invasion of U‐2 OS human osteosarcoma cells. We also found that CECF inhibited activities of matrix metalloproteinases‐2 (MMP‐2) and matrix metalloproteinases‐9 (MMP‐9). CECF decreased protein levels of FAK, PKC, SOS1, MKK7, MEKK3, GRB2, NF‐κB p65, COX‐2, HIF‐1α, PI3K, Rho A, ROCK‐1, IRE‐1α, p‐JNK1/2, p‐ERK1/2, p‐p38, Ras, p‐PERK, MMP‐2, MMP‐9, and VEGF in U‐2 OS cells. Results of this study indicate that CECF may have potential as a novel anticancer agent for the treatment of osteosarcoma by inhibiting migration and invasion of cancer cells © 2013 Wiley Periodicals, Inc. Environ Toxicol 30: 53–63, 2015. Nutzungsrecht: © 2013 Wiley Periodicals, Inc. Corni Fructus U‐2 OS human osteosarcoma cells invasion migration CECF crude extract of Matrix Metalloproteinase Inhibitors - isolation & purification Drugs, Chinese Herbal - isolation & purification Matrix Metalloproteinase 2 - metabolism Matrix Metalloproteinase 9 - metabolism Drugs, Chinese Herbal - pharmacology Cell Survival - drug effects Osteosarcoma - pathology Antineoplastic Agents, Phytogenic - isolation & purification Cornus - chemistry MAP Kinase Signaling System - drug effects Bone Neoplasms - pathology Cell Movement - drug effects NF-kappa B - metabolism Antineoplastic Agents, Phytogenic - pharmacology Matrix Metalloproteinase Inhibitors - pharmacology Lin, Ju‐Hwa oth Lien, Jin‐Cherng oth Hsu, Shu‐Chun oth Chueh, Fu‐Shin oth Yu, Chien‐Chih oth Wu, Ping‐Ping oth Huang, Yi‐Ping oth Lin, Jaung‐Geng oth Chung, Jing‐Gung oth Enthalten in Environmental toxicology New York, NY : Wiley, 1999 30(2015), 1, Seite 53-63 (DE-627)254912214 (DE-600)1463449-1 (DE-576)079598412 1520-4081 nnns volume:30 year:2015 number:1 pages:53-63 http://dx.doi.org/10.1002/tox.21894 Volltext http://onlinelibrary.wiley.com/doi/10.1002/tox.21894/abstract http://www.ncbi.nlm.nih.gov/pubmed/23955962 http://search.proquest.com/docview/1639601262 GBV_USEFLAG_A SYSFLAG_A GBV_OLC SSG-OLC-UMW SSG-OLC-ARC SSG-OLC-PHA SSG-OLC-DE-84 GBV_ILN_70 GBV_ILN_4012 GBV_ILN_4219 43.00 AVZ AR 30 2015 1 53-63 |
| language |
English |
| source |
Enthalten in Environmental toxicology 30(2015), 1, Seite 53-63 volume:30 year:2015 number:1 pages:53-63 |
| sourceStr |
Enthalten in Environmental toxicology 30(2015), 1, Seite 53-63 volume:30 year:2015 number:1 pages:53-63 |
| format_phy_str_mv |
Article |
| institution |
findex.gbv.de |
| topic_facet |
Corni Fructus U‐2 OS human osteosarcoma cells invasion migration CECF crude extract of Matrix Metalloproteinase Inhibitors - isolation & purification Drugs, Chinese Herbal - isolation & purification Matrix Metalloproteinase 2 - metabolism Matrix Metalloproteinase 9 - metabolism Drugs, Chinese Herbal - pharmacology Cell Survival - drug effects Osteosarcoma - pathology Antineoplastic Agents, Phytogenic - isolation & purification Cornus - chemistry MAP Kinase Signaling System - drug effects Bone Neoplasms - pathology Cell Movement - drug effects NF-kappa B - metabolism Antineoplastic Agents, Phytogenic - pharmacology Matrix Metalloproteinase Inhibitors - pharmacology |
| dewey-raw |
690 |
| isfreeaccess_bool |
false |
| container_title |
Environmental toxicology |
| authorswithroles_txt_mv |
Liao, Ching‐Lung @@aut@@ Lin, Ju‐Hwa @@oth@@ Lien, Jin‐Cherng @@oth@@ Hsu, Shu‐Chun @@oth@@ Chueh, Fu‐Shin @@oth@@ Yu, Chien‐Chih @@oth@@ Wu, Ping‐Ping @@oth@@ Huang, Yi‐Ping @@oth@@ Lin, Jaung‐Geng @@oth@@ Chung, Jing‐Gung @@oth@@ |
| publishDateDaySort_date |
2015-01-01T00:00:00Z |
| hierarchy_top_id |
254912214 |
| dewey-sort |
3690 |
| id |
OLC1957481323 |
| language_de |
englisch |
| fullrecord |
<?xml version="1.0" encoding="UTF-8"?><collection xmlns="http://www.loc.gov/MARC21/slim"><record><leader>01000caa a2200265 4500</leader><controlfield tag="001">OLC1957481323</controlfield><controlfield tag="003">DE-627</controlfield><controlfield tag="005">20230518141419.0</controlfield><controlfield tag="007">tu</controlfield><controlfield tag="008">160206s2015 xx ||||| 00| ||eng c</controlfield><datafield tag="024" ind1="7" ind2=" "><subfield code="a">10.1002/tox.21894</subfield><subfield code="2">doi</subfield></datafield><datafield tag="028" ind1="5" ind2="2"><subfield code="a">PQ20160617</subfield></datafield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(DE-627)OLC1957481323</subfield></datafield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(DE-599)GBVOLC1957481323</subfield></datafield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(PRQ)p3041-f0c7e53c0c43a35c8c629bd98f02b3a7a81b043495246de54d6f16a6c652118a3</subfield></datafield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(KEY)0154138220150000030000100053crudeextractofcornifructusinhibitsthemigrationandi</subfield></datafield><datafield tag="040" ind1=" " ind2=" "><subfield code="a">DE-627</subfield><subfield code="b">ger</subfield><subfield code="c">DE-627</subfield><subfield code="e">rakwb</subfield></datafield><datafield tag="041" ind1=" " ind2=" "><subfield code="a">eng</subfield></datafield><datafield tag="082" ind1="0" ind2="4"><subfield code="a">690</subfield><subfield code="q">ZDB</subfield></datafield><datafield tag="084" ind1=" " ind2=" "><subfield code="a">43.00</subfield><subfield code="2">bkl</subfield></datafield><datafield tag="100" ind1="1" ind2=" "><subfield code="a">Liao, Ching‐Lung</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="245" ind1="1" ind2="4"><subfield code="a">The crude extract of Corni Fructus inhibits the migration and invasion of U‐2 OS human osteosarcoma cells through the inhibition of matrix metalloproteinase‐2/‐9 by MAPK signaling</subfield></datafield><datafield tag="264" ind1=" " ind2="1"><subfield code="c">2015</subfield></datafield><datafield tag="336" ind1=" " ind2=" "><subfield code="a">Text</subfield><subfield code="b">txt</subfield><subfield code="2">rdacontent</subfield></datafield><datafield tag="337" ind1=" " ind2=" "><subfield code="a">ohne Hilfsmittel zu benutzen</subfield><subfield code="b">n</subfield><subfield code="2">rdamedia</subfield></datafield><datafield tag="338" ind1=" " ind2=" "><subfield code="a">Band</subfield><subfield code="b">nc</subfield><subfield code="2">rdacarrier</subfield></datafield><datafield tag="520" ind1=" " ind2=" "><subfield code="a">Osteosarcoma is the most common primary malignancy of the bone cancers. In the Chinese population, the crude extract of Corni Fructus (CECF) has been used as Traditional Chinese medicine to treat several different diseases for hundreds of years. In the present study, effects of CECF on inhibition of migration and invasion in U‐2 OS human osteosarcoma cells were examined. CECF significantly inhibited migration and invasion of U‐2 OS human osteosarcoma cells. We also found that CECF inhibited activities of matrix metalloproteinases‐2 (MMP‐2) and matrix metalloproteinases‐9 (MMP‐9). CECF decreased protein levels of FAK, PKC, SOS1, MKK7, MEKK3, GRB2, NF‐κB p65, COX‐2, HIF‐1α, PI3K, Rho A, ROCK‐1, IRE‐1α, p‐JNK1/2, p‐ERK1/2, p‐p38, Ras, p‐PERK, MMP‐2, MMP‐9, and VEGF in U‐2 OS cells. Results of this study indicate that CECF may have potential as a novel anticancer agent for the treatment of osteosarcoma by inhibiting migration and invasion of cancer cells © 2013 Wiley Periodicals, Inc. Environ Toxicol 30: 53–63, 2015.</subfield></datafield><datafield tag="540" ind1=" " ind2=" "><subfield code="a">Nutzungsrecht: © 2013 Wiley Periodicals, Inc.</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Corni Fructus</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">U‐2 OS human osteosarcoma cells</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">invasion</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">migration</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">CECF</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">crude extract of</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Matrix Metalloproteinase Inhibitors - isolation & purification</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Drugs, Chinese Herbal - isolation & purification</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Matrix Metalloproteinase 2 - metabolism</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Matrix Metalloproteinase 9 - metabolism</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Drugs, Chinese Herbal - pharmacology</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Cell Survival - drug effects</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Osteosarcoma - pathology</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Antineoplastic Agents, Phytogenic - isolation & purification</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Cornus - chemistry</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">MAP Kinase Signaling System - drug effects</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Bone Neoplasms - pathology</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Cell Movement - drug effects</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">NF-kappa B - metabolism</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Antineoplastic Agents, Phytogenic - pharmacology</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Matrix Metalloproteinase Inhibitors - pharmacology</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Lin, Ju‐Hwa</subfield><subfield code="4">oth</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Lien, Jin‐Cherng</subfield><subfield code="4">oth</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Hsu, Shu‐Chun</subfield><subfield code="4">oth</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Chueh, Fu‐Shin</subfield><subfield code="4">oth</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Yu, Chien‐Chih</subfield><subfield code="4">oth</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Wu, Ping‐Ping</subfield><subfield code="4">oth</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Huang, Yi‐Ping</subfield><subfield code="4">oth</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Lin, Jaung‐Geng</subfield><subfield code="4">oth</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Chung, Jing‐Gung</subfield><subfield code="4">oth</subfield></datafield><datafield tag="773" ind1="0" ind2="8"><subfield code="i">Enthalten in</subfield><subfield code="t">Environmental toxicology</subfield><subfield code="d">New York, NY : Wiley, 1999</subfield><subfield code="g">30(2015), 1, Seite 53-63</subfield><subfield code="w">(DE-627)254912214</subfield><subfield code="w">(DE-600)1463449-1</subfield><subfield code="w">(DE-576)079598412</subfield><subfield code="x">1520-4081</subfield><subfield code="7">nnns</subfield></datafield><datafield tag="773" ind1="1" ind2="8"><subfield code="g">volume:30</subfield><subfield code="g">year:2015</subfield><subfield code="g">number:1</subfield><subfield code="g">pages:53-63</subfield></datafield><datafield tag="856" ind1="4" ind2="1"><subfield code="u">http://dx.doi.org/10.1002/tox.21894</subfield><subfield code="3">Volltext</subfield></datafield><datafield tag="856" ind1="4" ind2="2"><subfield code="u">http://onlinelibrary.wiley.com/doi/10.1002/tox.21894/abstract</subfield></datafield><datafield tag="856" ind1="4" ind2="2"><subfield code="u">http://www.ncbi.nlm.nih.gov/pubmed/23955962</subfield></datafield><datafield tag="856" ind1="4" ind2="2"><subfield code="u">http://search.proquest.com/docview/1639601262</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_USEFLAG_A</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">SYSFLAG_A</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_OLC</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">SSG-OLC-UMW</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">SSG-OLC-ARC</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">SSG-OLC-PHA</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">SSG-OLC-DE-84</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_70</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4012</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4219</subfield></datafield><datafield tag="936" ind1="b" ind2="k"><subfield code="a">43.00</subfield><subfield code="q">AVZ</subfield></datafield><datafield tag="951" ind1=" " ind2=" "><subfield code="a">AR</subfield></datafield><datafield tag="952" ind1=" " ind2=" "><subfield code="d">30</subfield><subfield code="j">2015</subfield><subfield code="e">1</subfield><subfield code="h">53-63</subfield></datafield></record></collection>
|
| author |
Liao, Ching‐Lung |
| spellingShingle |
Liao, Ching‐Lung ddc 690 bkl 43.00 misc Corni Fructus misc U‐2 OS human osteosarcoma cells misc invasion misc migration misc CECF misc crude extract of misc Matrix Metalloproteinase Inhibitors - isolation & purification misc Drugs, Chinese Herbal - isolation & purification misc Matrix Metalloproteinase 2 - metabolism misc Matrix Metalloproteinase 9 - metabolism misc Drugs, Chinese Herbal - pharmacology misc Cell Survival - drug effects misc Osteosarcoma - pathology misc Antineoplastic Agents, Phytogenic - isolation & purification misc Cornus - chemistry misc MAP Kinase Signaling System - drug effects misc Bone Neoplasms - pathology misc Cell Movement - drug effects misc NF-kappa B - metabolism misc Antineoplastic Agents, Phytogenic - pharmacology misc Matrix Metalloproteinase Inhibitors - pharmacology The crude extract of Corni Fructus inhibits the migration and invasion of U‐2 OS human osteosarcoma cells through the inhibition of matrix metalloproteinase‐2/‐9 by MAPK signaling |
| authorStr |
Liao, Ching‐Lung |
| ppnlink_with_tag_str_mv |
@@773@@(DE-627)254912214 |
| format |
Article |
| dewey-ones |
690 - Buildings |
| delete_txt_mv |
keep |
| author_role |
aut |
| collection |
OLC |
| remote_str |
false |
| illustrated |
Not Illustrated |
| issn |
1520-4081 |
| topic_title |
690 ZDB 43.00 bkl The crude extract of Corni Fructus inhibits the migration and invasion of U‐2 OS human osteosarcoma cells through the inhibition of matrix metalloproteinase‐2/‐9 by MAPK signaling Corni Fructus U‐2 OS human osteosarcoma cells invasion migration CECF crude extract of Matrix Metalloproteinase Inhibitors - isolation & purification Drugs, Chinese Herbal - isolation & purification Matrix Metalloproteinase 2 - metabolism Matrix Metalloproteinase 9 - metabolism Drugs, Chinese Herbal - pharmacology Cell Survival - drug effects Osteosarcoma - pathology Antineoplastic Agents, Phytogenic - isolation & purification Cornus - chemistry MAP Kinase Signaling System - drug effects Bone Neoplasms - pathology Cell Movement - drug effects NF-kappa B - metabolism Antineoplastic Agents, Phytogenic - pharmacology Matrix Metalloproteinase Inhibitors - pharmacology |
| topic |
ddc 690 bkl 43.00 misc Corni Fructus misc U‐2 OS human osteosarcoma cells misc invasion misc migration misc CECF misc crude extract of misc Matrix Metalloproteinase Inhibitors - isolation & purification misc Drugs, Chinese Herbal - isolation & purification misc Matrix Metalloproteinase 2 - metabolism misc Matrix Metalloproteinase 9 - metabolism misc Drugs, Chinese Herbal - pharmacology misc Cell Survival - drug effects misc Osteosarcoma - pathology misc Antineoplastic Agents, Phytogenic - isolation & purification misc Cornus - chemistry misc MAP Kinase Signaling System - drug effects misc Bone Neoplasms - pathology misc Cell Movement - drug effects misc NF-kappa B - metabolism misc Antineoplastic Agents, Phytogenic - pharmacology misc Matrix Metalloproteinase Inhibitors - pharmacology |
| topic_unstemmed |
ddc 690 bkl 43.00 misc Corni Fructus misc U‐2 OS human osteosarcoma cells misc invasion misc migration misc CECF misc crude extract of misc Matrix Metalloproteinase Inhibitors - isolation & purification misc Drugs, Chinese Herbal - isolation & purification misc Matrix Metalloproteinase 2 - metabolism misc Matrix Metalloproteinase 9 - metabolism misc Drugs, Chinese Herbal - pharmacology misc Cell Survival - drug effects misc Osteosarcoma - pathology misc Antineoplastic Agents, Phytogenic - isolation & purification misc Cornus - chemistry misc MAP Kinase Signaling System - drug effects misc Bone Neoplasms - pathology misc Cell Movement - drug effects misc NF-kappa B - metabolism misc Antineoplastic Agents, Phytogenic - pharmacology misc Matrix Metalloproteinase Inhibitors - pharmacology |
| topic_browse |
ddc 690 bkl 43.00 misc Corni Fructus misc U‐2 OS human osteosarcoma cells misc invasion misc migration misc CECF misc crude extract of misc Matrix Metalloproteinase Inhibitors - isolation & purification misc Drugs, Chinese Herbal - isolation & purification misc Matrix Metalloproteinase 2 - metabolism misc Matrix Metalloproteinase 9 - metabolism misc Drugs, Chinese Herbal - pharmacology misc Cell Survival - drug effects misc Osteosarcoma - pathology misc Antineoplastic Agents, Phytogenic - isolation & purification misc Cornus - chemistry misc MAP Kinase Signaling System - drug effects misc Bone Neoplasms - pathology misc Cell Movement - drug effects misc NF-kappa B - metabolism misc Antineoplastic Agents, Phytogenic - pharmacology misc Matrix Metalloproteinase Inhibitors - pharmacology |
| format_facet |
Aufsätze Gedruckte Aufsätze |
| format_main_str_mv |
Text Zeitschrift/Artikel |
| carriertype_str_mv |
nc |
| author2_variant |
j l jl j l jl s h sh f c fc c y cy p w pw y h yh j l jl j c jc |
| hierarchy_parent_title |
Environmental toxicology |
| hierarchy_parent_id |
254912214 |
| dewey-tens |
690 - Building & construction |
| hierarchy_top_title |
Environmental toxicology |
| isfreeaccess_txt |
false |
| familylinks_str_mv |
(DE-627)254912214 (DE-600)1463449-1 (DE-576)079598412 |
| title |
The crude extract of Corni Fructus inhibits the migration and invasion of U‐2 OS human osteosarcoma cells through the inhibition of matrix metalloproteinase‐2/‐9 by MAPK signaling |
| ctrlnum |
(DE-627)OLC1957481323 (DE-599)GBVOLC1957481323 (PRQ)p3041-f0c7e53c0c43a35c8c629bd98f02b3a7a81b043495246de54d6f16a6c652118a3 (KEY)0154138220150000030000100053crudeextractofcornifructusinhibitsthemigrationandi |
| title_full |
The crude extract of Corni Fructus inhibits the migration and invasion of U‐2 OS human osteosarcoma cells through the inhibition of matrix metalloproteinase‐2/‐9 by MAPK signaling |
| author_sort |
Liao, Ching‐Lung |
| journal |
Environmental toxicology |
| journalStr |
Environmental toxicology |
| lang_code |
eng |
| isOA_bool |
false |
| dewey-hundreds |
600 - Technology |
| recordtype |
marc |
| publishDateSort |
2015 |
| contenttype_str_mv |
txt |
| container_start_page |
53 |
| author_browse |
Liao, Ching‐Lung |
| container_volume |
30 |
| class |
690 ZDB 43.00 bkl |
| format_se |
Aufsätze |
| author-letter |
Liao, Ching‐Lung |
| doi_str_mv |
10.1002/tox.21894 |
| dewey-full |
690 |
| title_sort |
crude extract of corni fructus inhibits the migration and invasion of u‐2 os human osteosarcoma cells through the inhibition of matrix metalloproteinase‐2/‐9 by mapk signaling |
| title_auth |
The crude extract of Corni Fructus inhibits the migration and invasion of U‐2 OS human osteosarcoma cells through the inhibition of matrix metalloproteinase‐2/‐9 by MAPK signaling |
| abstract |
Osteosarcoma is the most common primary malignancy of the bone cancers. In the Chinese population, the crude extract of Corni Fructus (CECF) has been used as Traditional Chinese medicine to treat several different diseases for hundreds of years. In the present study, effects of CECF on inhibition of migration and invasion in U‐2 OS human osteosarcoma cells were examined. CECF significantly inhibited migration and invasion of U‐2 OS human osteosarcoma cells. We also found that CECF inhibited activities of matrix metalloproteinases‐2 (MMP‐2) and matrix metalloproteinases‐9 (MMP‐9). CECF decreased protein levels of FAK, PKC, SOS1, MKK7, MEKK3, GRB2, NF‐κB p65, COX‐2, HIF‐1α, PI3K, Rho A, ROCK‐1, IRE‐1α, p‐JNK1/2, p‐ERK1/2, p‐p38, Ras, p‐PERK, MMP‐2, MMP‐9, and VEGF in U‐2 OS cells. Results of this study indicate that CECF may have potential as a novel anticancer agent for the treatment of osteosarcoma by inhibiting migration and invasion of cancer cells © 2013 Wiley Periodicals, Inc. Environ Toxicol 30: 53–63, 2015. |
| abstractGer |
Osteosarcoma is the most common primary malignancy of the bone cancers. In the Chinese population, the crude extract of Corni Fructus (CECF) has been used as Traditional Chinese medicine to treat several different diseases for hundreds of years. In the present study, effects of CECF on inhibition of migration and invasion in U‐2 OS human osteosarcoma cells were examined. CECF significantly inhibited migration and invasion of U‐2 OS human osteosarcoma cells. We also found that CECF inhibited activities of matrix metalloproteinases‐2 (MMP‐2) and matrix metalloproteinases‐9 (MMP‐9). CECF decreased protein levels of FAK, PKC, SOS1, MKK7, MEKK3, GRB2, NF‐κB p65, COX‐2, HIF‐1α, PI3K, Rho A, ROCK‐1, IRE‐1α, p‐JNK1/2, p‐ERK1/2, p‐p38, Ras, p‐PERK, MMP‐2, MMP‐9, and VEGF in U‐2 OS cells. Results of this study indicate that CECF may have potential as a novel anticancer agent for the treatment of osteosarcoma by inhibiting migration and invasion of cancer cells © 2013 Wiley Periodicals, Inc. Environ Toxicol 30: 53–63, 2015. |
| abstract_unstemmed |
Osteosarcoma is the most common primary malignancy of the bone cancers. In the Chinese population, the crude extract of Corni Fructus (CECF) has been used as Traditional Chinese medicine to treat several different diseases for hundreds of years. In the present study, effects of CECF on inhibition of migration and invasion in U‐2 OS human osteosarcoma cells were examined. CECF significantly inhibited migration and invasion of U‐2 OS human osteosarcoma cells. We also found that CECF inhibited activities of matrix metalloproteinases‐2 (MMP‐2) and matrix metalloproteinases‐9 (MMP‐9). CECF decreased protein levels of FAK, PKC, SOS1, MKK7, MEKK3, GRB2, NF‐κB p65, COX‐2, HIF‐1α, PI3K, Rho A, ROCK‐1, IRE‐1α, p‐JNK1/2, p‐ERK1/2, p‐p38, Ras, p‐PERK, MMP‐2, MMP‐9, and VEGF in U‐2 OS cells. Results of this study indicate that CECF may have potential as a novel anticancer agent for the treatment of osteosarcoma by inhibiting migration and invasion of cancer cells © 2013 Wiley Periodicals, Inc. Environ Toxicol 30: 53–63, 2015. |
| collection_details |
GBV_USEFLAG_A SYSFLAG_A GBV_OLC SSG-OLC-UMW SSG-OLC-ARC SSG-OLC-PHA SSG-OLC-DE-84 GBV_ILN_70 GBV_ILN_4012 GBV_ILN_4219 |
| container_issue |
1 |
| title_short |
The crude extract of Corni Fructus inhibits the migration and invasion of U‐2 OS human osteosarcoma cells through the inhibition of matrix metalloproteinase‐2/‐9 by MAPK signaling |
| url |
http://dx.doi.org/10.1002/tox.21894 http://onlinelibrary.wiley.com/doi/10.1002/tox.21894/abstract http://www.ncbi.nlm.nih.gov/pubmed/23955962 http://search.proquest.com/docview/1639601262 |
| remote_bool |
false |
| author2 |
Lin, Ju‐Hwa Lien, Jin‐Cherng Hsu, Shu‐Chun Chueh, Fu‐Shin Yu, Chien‐Chih Wu, Ping‐Ping Huang, Yi‐Ping Lin, Jaung‐Geng Chung, Jing‐Gung |
| author2Str |
Lin, Ju‐Hwa Lien, Jin‐Cherng Hsu, Shu‐Chun Chueh, Fu‐Shin Yu, Chien‐Chih Wu, Ping‐Ping Huang, Yi‐Ping Lin, Jaung‐Geng Chung, Jing‐Gung |
| ppnlink |
254912214 |
| mediatype_str_mv |
n |
| isOA_txt |
false |
| hochschulschrift_bool |
false |
| author2_role |
oth oth oth oth oth oth oth oth oth |
| doi_str |
10.1002/tox.21894 |
| up_date |
2024-07-04T00:24:43.905Z |
| _version_ |
1803605963080466433 |
| fullrecord_marcxml |
<?xml version="1.0" encoding="UTF-8"?><collection xmlns="http://www.loc.gov/MARC21/slim"><record><leader>01000caa a2200265 4500</leader><controlfield tag="001">OLC1957481323</controlfield><controlfield tag="003">DE-627</controlfield><controlfield tag="005">20230518141419.0</controlfield><controlfield tag="007">tu</controlfield><controlfield tag="008">160206s2015 xx ||||| 00| ||eng c</controlfield><datafield tag="024" ind1="7" ind2=" "><subfield code="a">10.1002/tox.21894</subfield><subfield code="2">doi</subfield></datafield><datafield tag="028" ind1="5" ind2="2"><subfield code="a">PQ20160617</subfield></datafield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(DE-627)OLC1957481323</subfield></datafield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(DE-599)GBVOLC1957481323</subfield></datafield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(PRQ)p3041-f0c7e53c0c43a35c8c629bd98f02b3a7a81b043495246de54d6f16a6c652118a3</subfield></datafield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(KEY)0154138220150000030000100053crudeextractofcornifructusinhibitsthemigrationandi</subfield></datafield><datafield tag="040" ind1=" " ind2=" "><subfield code="a">DE-627</subfield><subfield code="b">ger</subfield><subfield code="c">DE-627</subfield><subfield code="e">rakwb</subfield></datafield><datafield tag="041" ind1=" " ind2=" "><subfield code="a">eng</subfield></datafield><datafield tag="082" ind1="0" ind2="4"><subfield code="a">690</subfield><subfield code="q">ZDB</subfield></datafield><datafield tag="084" ind1=" " ind2=" "><subfield code="a">43.00</subfield><subfield code="2">bkl</subfield></datafield><datafield tag="100" ind1="1" ind2=" "><subfield code="a">Liao, Ching‐Lung</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="245" ind1="1" ind2="4"><subfield code="a">The crude extract of Corni Fructus inhibits the migration and invasion of U‐2 OS human osteosarcoma cells through the inhibition of matrix metalloproteinase‐2/‐9 by MAPK signaling</subfield></datafield><datafield tag="264" ind1=" " ind2="1"><subfield code="c">2015</subfield></datafield><datafield tag="336" ind1=" " ind2=" "><subfield code="a">Text</subfield><subfield code="b">txt</subfield><subfield code="2">rdacontent</subfield></datafield><datafield tag="337" ind1=" " ind2=" "><subfield code="a">ohne Hilfsmittel zu benutzen</subfield><subfield code="b">n</subfield><subfield code="2">rdamedia</subfield></datafield><datafield tag="338" ind1=" " ind2=" "><subfield code="a">Band</subfield><subfield code="b">nc</subfield><subfield code="2">rdacarrier</subfield></datafield><datafield tag="520" ind1=" " ind2=" "><subfield code="a">Osteosarcoma is the most common primary malignancy of the bone cancers. In the Chinese population, the crude extract of Corni Fructus (CECF) has been used as Traditional Chinese medicine to treat several different diseases for hundreds of years. In the present study, effects of CECF on inhibition of migration and invasion in U‐2 OS human osteosarcoma cells were examined. CECF significantly inhibited migration and invasion of U‐2 OS human osteosarcoma cells. We also found that CECF inhibited activities of matrix metalloproteinases‐2 (MMP‐2) and matrix metalloproteinases‐9 (MMP‐9). CECF decreased protein levels of FAK, PKC, SOS1, MKK7, MEKK3, GRB2, NF‐κB p65, COX‐2, HIF‐1α, PI3K, Rho A, ROCK‐1, IRE‐1α, p‐JNK1/2, p‐ERK1/2, p‐p38, Ras, p‐PERK, MMP‐2, MMP‐9, and VEGF in U‐2 OS cells. Results of this study indicate that CECF may have potential as a novel anticancer agent for the treatment of osteosarcoma by inhibiting migration and invasion of cancer cells © 2013 Wiley Periodicals, Inc. Environ Toxicol 30: 53–63, 2015.</subfield></datafield><datafield tag="540" ind1=" " ind2=" "><subfield code="a">Nutzungsrecht: © 2013 Wiley Periodicals, Inc.</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Corni Fructus</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">U‐2 OS human osteosarcoma cells</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">invasion</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">migration</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">CECF</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">crude extract of</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Matrix Metalloproteinase Inhibitors - isolation & purification</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Drugs, Chinese Herbal - isolation & purification</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Matrix Metalloproteinase 2 - metabolism</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Matrix Metalloproteinase 9 - metabolism</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Drugs, Chinese Herbal - pharmacology</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Cell Survival - drug effects</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Osteosarcoma - pathology</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Antineoplastic Agents, Phytogenic - isolation & purification</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Cornus - chemistry</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">MAP Kinase Signaling System - drug effects</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Bone Neoplasms - pathology</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Cell Movement - drug effects</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">NF-kappa B - metabolism</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Antineoplastic Agents, Phytogenic - pharmacology</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Matrix Metalloproteinase Inhibitors - pharmacology</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Lin, Ju‐Hwa</subfield><subfield code="4">oth</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Lien, Jin‐Cherng</subfield><subfield code="4">oth</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Hsu, Shu‐Chun</subfield><subfield code="4">oth</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Chueh, Fu‐Shin</subfield><subfield code="4">oth</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Yu, Chien‐Chih</subfield><subfield code="4">oth</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Wu, Ping‐Ping</subfield><subfield code="4">oth</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Huang, Yi‐Ping</subfield><subfield code="4">oth</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Lin, Jaung‐Geng</subfield><subfield code="4">oth</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Chung, Jing‐Gung</subfield><subfield code="4">oth</subfield></datafield><datafield tag="773" ind1="0" ind2="8"><subfield code="i">Enthalten in</subfield><subfield code="t">Environmental toxicology</subfield><subfield code="d">New York, NY : Wiley, 1999</subfield><subfield code="g">30(2015), 1, Seite 53-63</subfield><subfield code="w">(DE-627)254912214</subfield><subfield code="w">(DE-600)1463449-1</subfield><subfield code="w">(DE-576)079598412</subfield><subfield code="x">1520-4081</subfield><subfield code="7">nnns</subfield></datafield><datafield tag="773" ind1="1" ind2="8"><subfield code="g">volume:30</subfield><subfield code="g">year:2015</subfield><subfield code="g">number:1</subfield><subfield code="g">pages:53-63</subfield></datafield><datafield tag="856" ind1="4" ind2="1"><subfield code="u">http://dx.doi.org/10.1002/tox.21894</subfield><subfield code="3">Volltext</subfield></datafield><datafield tag="856" ind1="4" ind2="2"><subfield code="u">http://onlinelibrary.wiley.com/doi/10.1002/tox.21894/abstract</subfield></datafield><datafield tag="856" ind1="4" ind2="2"><subfield code="u">http://www.ncbi.nlm.nih.gov/pubmed/23955962</subfield></datafield><datafield tag="856" ind1="4" ind2="2"><subfield code="u">http://search.proquest.com/docview/1639601262</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_USEFLAG_A</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">SYSFLAG_A</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_OLC</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">SSG-OLC-UMW</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">SSG-OLC-ARC</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">SSG-OLC-PHA</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">SSG-OLC-DE-84</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_70</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4012</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4219</subfield></datafield><datafield tag="936" ind1="b" ind2="k"><subfield code="a">43.00</subfield><subfield code="q">AVZ</subfield></datafield><datafield tag="951" ind1=" " ind2=" "><subfield code="a">AR</subfield></datafield><datafield tag="952" ind1=" " ind2=" "><subfield code="d">30</subfield><subfield code="j">2015</subfield><subfield code="e">1</subfield><subfield code="h">53-63</subfield></datafield></record></collection>
|
| score |
7.3988304 |